Article (Scientific journals)
La fenetre implantatoire
Perrier D'Hauterive, Sophie; Charlet-Renard, Jeanne de Chantal; Goffin, Frédéric et al.
2002In Journal de Gynécologie, Obstétrique et Biologie de la Reproduction, 31 (5), p. 440-55
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Keywords :
Implantation; Uterine receptivity; angiogenesis
Abstract :
BACKGROUND: Embryo implantation is a complex event involving apposition followed by adhesion of the blastocyst to the maternal endometrium, and finally invasion of this endometrium. Though implantation could occur in any human tissue, the endometrium is the only tissue where embryo implantation cannot occur except during a restricted period called the implantation window. During this window, the endometrium is highly receptive to the embryo. MATERIAL: and methods. We reviewed the literature concerning the different factors involved in improved endometrial receptivity and implantation. RESULTS: Maternal - embryo crosstalk is favored by the implantation window. Endometrial receptivity results from the acquisition of ligands or receptors facilitating apposition, then adhesion of the embryo, or from the loss of components preventing it. The molecular basis of the implantation window remains to be defined. CONCLUSION: Despite progress in assisted reproduction technologies, the lack of control of implantation remains a major obstacle to successful pregnancy. It is of prime importance to determine the characteristic features of a receptive endometrium and, among the many markers proposed by in vitro studies, to analyze in humans those demonstrated by knock-out experiments to play a crucial role in mice.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Perrier D'Hauterive, Sophie ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Charlet-Renard, Jeanne de Chantal ;  Centre Hospitalier Universitaire de Liège - CHU > Endocrinologie clinique
Goffin, Frédéric ;  Centre Hospitalier Universitaire de Liège - CHU > Gynécologie-Obstétrique CHR
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Geenen, Vincent ;  Université de Liège - ULiège > Centre d'immunologie
Language :
French
Title :
La fenetre implantatoire
Alternative titles :
The Implantation Window
Publication date :
September 2002
Journal title :
Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
ISSN :
0368-2315
eISSN :
1773-0430
Publisher :
Masson et Cie, Paris, France
Volume :
31
Issue :
5
Pages :
440-55
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 January 2013

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