[en] During the last 10 years, the conference on 'Steroids and Nervous System' held in Torino (Italy) has been an important international point of discussion for scientists involved in this exciting and expanding research field. The present review aims to recapitulate the main topics that have been presented through the various meetings. Two broad areas have been explored: the impact of gonadal hormones on brain circuits and behaviour, as well as the mechanism of action of neuroactive steroids. Relationships among steroids, brain and behaviour, the sexual differentiation of the brain and the impact of gonadal hormones, the interactions of exogenous steroidal molecules (endocrine disrupters) with neural circuits and behaviour, and how gonadal steroids modulate the behaviour of gonadotrophin-releasing hormone neurones, have been the topics of several lectures and symposia during this series of meetings. At the same time, many contributions have been dedicated to the biosynthetic pathways, the physiopathological relevance of neurosteroids, the demonstration of the cellular localisation of different enzymes involved in neurosteroidogenesis, the mechanisms by which steroids may exert some of their effects, both the classical and nonclassical actions of different steroids, the role of neuroactive steroids on neurodegeneration, neuroprotection, and the response of the neural tissue to injury. In these 10 years, this field has significantly advanced and neuroactive steroids have emerged as new potential therapeutic tools to counteract neurodegenerative events.
Disciplines :
Zoologie Neurosciences & comportement
Auteur, co-auteur :
Panzica, G. C.
Balthazart, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Frye, C. A.
Garcia-Segura, L. M.
Herbison, A. E.
Mensah-Nyagan, A. G.
McCarthy, M. M.
Melcangi, R. C.
Langue du document :
Anglais
Titre :
Milestones on Steroids and the Nervous System: 10 Years of Basic and Translational Research.
Date de publication/diffusion :
2012
Titre du périodique :
Journal of Neuroendocrinology
ISSN :
0953-8194
eISSN :
1365-2826
Maison d'édition :
Blackwell Publishing, Oxford, Royaume-Uni
Volume/Tome :
24
Fascicule/Saison :
1
Pagination :
1-15
Peer reviewed :
Peer reviewed vérifié par ORBi
Commentaire :
(c) 2011 The Authors. Journal of Neuroendocrinology (c) 2011 Blackwell Publishing Ltd.
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