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See detailExploring the ability of tomorrow's leaders to support smart city projects
Bounazef, Djida ULiege; Crutzen, Nathalie ULiege

Conference (2019, June)

Purpose: The concept of smart city is more and more explored in different disciplines. The citizen and the community in general are highlighted as the core of a successful smart city transition, in which ... [more ▼]

Purpose: The concept of smart city is more and more explored in different disciplines. The citizen and the community in general are highlighted as the core of a successful smart city transition, in which strategic actors are transforming together a city. However, a dynamic collaborative model is effective only if communities are accepting and supporting the implemented projects. To explore this supportive willingness, this paper focuses on the image that tomorrow’s leaders, which can be categorized as potential smart citizens, build regarding local smart city projects. Design/methodology/approach: A quantitative research is developed on a sample composed by 215 tomorrow’s leaders in Belgium. A survey was designed and distributed online asking respondents to select uncertainties, opportunities and threats that they associate to smart city projects developed locally. A factor analysis is proposed to analyze the data. Findings: Smart city projects are perceived as an opportunity to reinforce sustainability, quality of life and city digitalization. As a result, tomorrow’s leaders are more supportive if they have a clear vision of potential benefits and consequences induced by local smart city projects. Research/practical implications: This research offers new insights on scholars developed by Jun and Weare. As for innovative programs, smart city projects need to be aligned to global social expectations and to subgroup-based interest (taking into account the age, the gender and the cultural identity) in order to reinforce the capacity of the ecosystem to accept change and to develop an adequate behavior. Originality/value: The paper proposes an original research in the Belgian context, where smart city policies are focusing on human factors. Thus, these findings help Belgian cities in understanding how citizens think and behave in face of a progressive transforming city. [less ▲]

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See detailLes citoyens et stratégies communales à l’ère de la smart city : Echanges et interactions entre sourds ?
Bounazef, Djida ULiege; Crutzen, Nathalie ULiege

Conference (2019, June)

Problématique Le concept de la smart city émerge comme une vision incitant à la créativité, à l’innovation et au changement inclusif. Différents écrits soulignent l’importance de la dynamique d’acteurs ... [more ▼]

Problématique Le concept de la smart city émerge comme une vision incitant à la créativité, à l’innovation et au changement inclusif. Différents écrits soulignent l’importance de la dynamique d’acteurs, et principalement le rôle du citoyen dans le développement de sa commune. Dès lors, différentes initiatives sont développées par les communes afin de renforcer les interactions avec l’écosystème. Toutefois, même si des efforts sont observés, est ce que les stratégies communales développées en vue de répondre aux attentes citoyennes reflètent réellement ce dont le citoyen a besoin ? Objet de recherche Depuis 2010, différentes communes belges s’inscrivent dans des politiques de transition durable et intelligente où la qualité de vie et les besoins du citoyen sont au cœur des stratégies communales. C’est dans ce sens que cette recherche explore si les communes entendent ou écoutent réellement le citoyen. La recherche explore, premièrement, la connaissance de la commune de l’ensemble des initiatives locales développées par l’écosystème, deuxièmement, la concordance entre les besoins du citoyen et les projets développés, et troisièmement, la volonté du citoyen à s’impliquer et interagir avec sa commune. Le but est de proposer un aperçu du potentiel impact « excitateur-résonateur » qui peut émerger des interactions entre ces deux parties. Méthodologie Cette recherche a nécessité la réalisation de deux études quantitatives. A cet effet, un recensement a été fait auprès de 123 communes belges et de 438 citoyens de catégories socioprofessionnelles confondues. Le questionnaire adressé aux communes a nécessité six mois de collecte des données. Les résultats descriptifs illustrent les différences entre les communes rurales et urbaines. Le questionnaire adressé aux citoyens est composé de questions ouvertes afin de récolter les impressions du citoyen rural et urbain. Une analyse sémantique des réponses avec un traitement statistique des mots clés a été réalisé pour extraire les principaux résultats. Résultats Un langage de sourd semble se confirmer entre le citoyen et sa commune. Les besoins des citoyens s’articulent autour de la culture, de la cohésion sociale, de l’écologie et du commerce de proximité, tandis que les communes priorisent la numérisation, la mobilité et la participation citoyenne. Par conséquent, 77% des citoyens se sentent peu entendus et pris en compte, même si 98% d’entre eux expriment une volonté de s’impliquer et d’interagir régulièrement (65,30%) par voie numérique avec leur commune. Ces résultats démontrent qu’il existe une relation d’excitateur-résonateur entre le citoyen et sa commune. Même si différentes initiatives sont implémentées pour renforcer la participation citoyenne, le citoyen ne voit pas à ce stade une volonté communale dans ce sens. Une bonne volonté est observée des deux parties, mais des améliorations doivent être conduites afin de développer des projets smart city répondants aux réels défis des gouvernements locaux et des citoyens afin d’assurer une réelle transition perceptible. [less ▲]

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See detailGardien de but au football
Kaux, Jean-François ULiege

Conference (2019, May 31)

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See detailStatue nei papiri letterari greci adespoti (seconda metà I a.C./ prima metà I d.C. – IV sec. d.C.)
Carlig, Nathan ULiege

Conference (2019, May 31)

Nel Catalogue des papyrus littéraires grecs et latins Mertens-Pack³ curato dal CEDOPAL dell’Università di Liegi (Belgio), sono recensiti quattro papiri adespota, tutti greci, relativi a statue. Sono ... [more ▼]

Nel Catalogue des papyrus littéraires grecs et latins Mertens-Pack³ curato dal CEDOPAL dell’Università di Liegi (Belgio), sono recensiti quattro papiri adespota, tutti greci, relativi a statue. Sono datati tra la seconda metà del I sec. a. C./prima metà del I sec. d.C. e il IV sec. d.C. In questa sede si propone uno studio di questi quattro testimoni da un punto di vista formale e contenutistico, con particolare attenzione ai termini usati per le statue, alle loro caratteristiche materiali – quando possibile ricavarle – e a cosa rappresentano, per tentare di identificare contesti di produzione e di fruizione di questi scritti. [less ▲]

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See detailThe impact of non-pharmacological approaches on the patient’s comfort after a cardiac surgery: A randomized controlled trial.
Rousseaux, Floriane ULiege; Puttaert, Ninon ULiege; LEDOUX, Didier ULiege et al

Conference (2019, May 30)

Different non-pharmacological techniques including hypnosis, music, and virtual reality (VR) are being used as complementary tools in the treatment of pain. A new technique which encompasses a combination ... [more ▼]

Different non-pharmacological techniques including hypnosis, music, and virtual reality (VR) are being used as complementary tools in the treatment of pain. A new technique which encompasses a combination of hypnosis and VR, called "virtual reality hypnosis" (VRH), should soon be used on a regular basis in clinical settings. The aim of this study is to better understand the impact of hypnosis, music, VR and VRH, and to investigate their influence on the patient’s perception of pain, anxiety and tiredness after a cardiac surgery in intensive care unit [less ▲]

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See detailStudy of the impact of non-pharmacological techniques (self-hypnosis/self-care) on cognitive complaints in cancer patients
Bicego, Aminata Yasmina ULiege; Grégoire, Charlotte; Cassol, Helena ULiege et al

Conference (2019, May 30)

Cancer diagnosis generates a number of physical, psychological and cognitive impairments such as memory, attentional and informational processing deficits that can undermine patients’ quality of life (QoL ... [more ▼]

Cancer diagnosis generates a number of physical, psychological and cognitive impairments such as memory, attentional and informational processing deficits that can undermine patients’ quality of life (QoL). Self-hypnosis combined to self-care learning have been used in the past years to treat these symptoms, at the moment of diagnosis, during and/or after the cancer treatments. However, the impact of self-hypnosis/self-care upon cognitive difficulties has not been investigated yet.The aim of this study is to better understand the impact of self hypnosis/self-care upon the cognitive functions by means of the Functional Assessment of Cancer Therapy-Cognitive Function1 (FACT-COG). [less ▲]

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See detailEntendre les voix du fleuve, éprouver les mots en crue : méandres poétiques d'un réseau géographique (Sénégal, Mauritanie)
Sow, Aboubakry ULiege

Conference (2019, May 29)

EcoSen: L'analyse écopoétique des littératures de la Vallée du Fleuve Sénégal a pour objectif de mettre en évidence les liens entre productions littéraires (orales, écrites) en langue peule et ... [more ▼]

EcoSen: L'analyse écopoétique des littératures de la Vallée du Fleuve Sénégal a pour objectif de mettre en évidence les liens entre productions littéraires (orales, écrites) en langue peule et environnement dans la Vallée du Fleuve Sénégal (sud de la Mauritanie, nord du Sénégal), par la mise en œuvre d’une approche théorique inédite pour les littératures de cette région, et en langues africaines en général : l’écopoétique. [less ▲]

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See detailA legal and economic analysis of B2C carsharing models
Vanrykel, Fanny ULiege; Bourgeois, Marc ULiege; De Borger, Bruno

Conference (2019, May 28)

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See detailPlace du PRP dans le traitement des tendinopathies patellaires
Kaux, Jean-François ULiege

Conference (2019, May 28)

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See detailRecent advances on 316L+WC Composite Coatings Processed by Laser Cladding
Maurizi-Enrici, Tommaso ULiege; Mario, Daniele ULiege; Dedry, Olivier ULiege et al

Conference (2019, May 28)

Austenitic stainless steels (e.g. SS316L) are widely used due to their corrosion resistance and good toughness. However, their applications are still limited by their relatively poor tribological ... [more ▼]

Austenitic stainless steels (e.g. SS316L) are widely used due to their corrosion resistance and good toughness. However, their applications are still limited by their relatively poor tribological properties at high temperature. Surface damage occurs in areas under contact loading. A composite coating in those zones appears as an interesting solution, combining the matrix material with hard reinforcements such as carbides. Among the possible reinforcements, WC or SiC are promising candidate due to their hardness, good affinity with iron-based materials and theoretical high melting temperature higher than 2200°C. Additive manufacturing, in particular laser cladding, is a suitable technique for the manufacturing of composite coatings with new properties, impossible to achieve with the classical manufacturing processes. This work considers the recent improvements on a metal matrix composite composed by 316L and reinforcements of WC particles (20 in vol.%). In order to obtain more insights into the relative contributions of the various strengthening mechanisms and the evolution of the new microstructure during fabrication of thick deposits, macro-hardness tests and nano-indentations have been performed. Those results were correlated with scanning electron microscopy (SEM) to completely characterize the effect of the out-of-equilibrium phases formed around the original reinforcements (see Figure below) on the metallic matrix. [less ▲]

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See detailExtensions of the Pascal triangle to words
Stipulanti, Manon ULiege

Conference (2019, May 28)

The Pascal triangle and the corresponding Sierpinski gasket are well-studied objects. They exhibit self-similarity features and have connections with dynamical systems, cellular automata, number theory ... [more ▼]

The Pascal triangle and the corresponding Sierpinski gasket are well-studied objects. They exhibit self-similarity features and have connections with dynamical systems, cellular automata, number theory and automatic sequences in combinatorics on words. In this talk, the first step is to recall the well-known link between those two objects. Then this link is exploited to define Pascal-like triangles associated with different numeration systems. Those new objects converge to analogues of the Sierpinski gasket. If time permits, other questions will be discussed. [less ▲]

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See detailDiabète et sport
Kaux, Jean-François ULiege; Radermecker, Régis ULiege

Conference (2019, May 27)

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See detailModelling the Ultimate Shear Behaviour of Deep Beams with Web Openings
Liu, Jian ULiege; Mihaylov, Boyan ULiege

Conference (2019, May 27)

Web openings are inevitably installed in deep beams in practice, while most of the research is focused on the shear behaviour of solid deep beams. The existence of web openings can reduce significantly ... [more ▼]

Web openings are inevitably installed in deep beams in practice, while most of the research is focused on the shear behaviour of solid deep beams. The existence of web openings can reduce significantly the shear capacity of deep beams and therefore cause safety problems. In this study, the typical shear failure modes and load transfer mechanisms of deep beams with web openings are firstly investigated, and based on the investigation a kinematic model is proposed for the shear capacity prediction. This kinematic model stems from the existing two parameter kinematic theory (2PKT), which was shown to provide satisfying predictions on shear capacity of solid deep beams. In the proposed model, one shear span is divided into two sub shear spans below and above the web opening, respectively. The steel layout at beam end beyond the web opening is crucial for resisting shear transferred above the web opening. Twenty seven deep beam specimens with web openings are used for the validation. The proposed kinematic model provides satisfying results, i.e. Vexp/Vpre: Avg=1.14 and COV=7.8%. [less ▲]

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See detailKinematic-based Approach for Complete Shear Behaviour of Deep FRC Beams
Mihaylov, Boyan ULiege; Liu, Jian ULiege; Tvrznikova, Karolina

Conference (2019, May 27)

While tests of deep fibre-reinforced concrete (FRC) beams have shown that steel fibres enhance the crack control and shear strength, the modelling of these effects in a simple and rational manner remains ... [more ▼]

While tests of deep fibre-reinforced concrete (FRC) beams have shown that steel fibres enhance the crack control and shear strength, the modelling of these effects in a simple and rational manner remains a challenging problem. Because FRC features enhanced tension behaviour, it is not well suited for the traditional strut-and-tie approach which neglects the tension in the concrete. Therefore, this paper proposes an alternative approach which focuses on the displacements in the critical shear cracks. The displacements are described with a kinematic model with two degrees of freedom, and are used with appropriate constitutive relationships to estimate the shear contribution of the fibres. This kinematics-based approach is validated with experimental data, and it is shown to capture adequately the complete pre- and post-peak behaviour of deep FRC beams. [less ▲]

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See detailOperational risk, uncertainty, and the economy: a smooth transition extreme value approach
Hambuckers, Julien ULiege; Kneib, Thomas

Conference (2019, May 26)

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See detailL'Harmonie du sensible et de l'intelligible dans la pensée musicale de J.-S. Bach
Dony, Arthur ULiege

Conference (2019, May 26)

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See detailGSC21 Satellite meeting on Cyanobacterial nomenclature and taxonomy
Wilmotte, Annick ULiege

Conference (2019, May 24)

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See detailJuan Rulfo en lengua francesa: trayectorias editoriales
Belleflamme, Clémence ULiege

Conference (2019, May 24)

Dentro de la narrativa hispanoamericana de la segunda mitad del siglo XX, las obras de Juan Rulfo representan una excepción, ya que son de las pocas que han sido traducidas y retraducidas al francés. En ... [more ▼]

Dentro de la narrativa hispanoamericana de la segunda mitad del siglo XX, las obras de Juan Rulfo representan una excepción, ya que son de las pocas que han sido traducidas y retraducidas al francés. En esta ponencia nos proponemos estudiar el fenómeno de la retraducción a través de los diferentes agentes implicados en las publicaciones de El Llano en llamas y Pedro Páramo en traducción, particularmente en la esfera cultural francesa. Así pues, enfocándonos en el polo de la producción, examinaremos el perfil de las distintas editoriales y de los traductores elegidos para cada versión francesa, así como el papel del agente literario, de los directores de colección y de los herederos del autor, representados por la Fundación Juan Rulfo. Delinear las trayectorias de esos textos nos ayudará a identificar los diversos factores que llevaron a publicar nuevas traducciones y, asimismo, a poner a prueba la “hipótesis de la retraducción” (nacida de las ideas de Berman en 1990), tomando en consideración no solamente las causas de índole traductológica (necesidad de colmar las lagunas o el envejecimiento de las traducciones existentes), sino también las preocupaciones de orden prioritariamente comercial. Además, se evocarán puntualmente las estrategias paratextuales, en la medida en que constituyen elementos centrales de “enunciación editorial” (Souchier, 1998). [less ▲]

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See detailBiometrics in identity documents: State surveillance?
Notermans, Pierre ULiege

Conference (2019, May 24)

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See detailLINKING BRAIN TO BEHAVIOR WITH BOTTOM-UP APPROACHES: OPPORTUNITIES AND CHALLENGES
Genon, Sarah ULiege

Conference (2019, May 23)

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See detailPost-peak trend of upper stratospheric hydrogen chloride derived from ground-based FTIR solar spectra and model simulations
Mahieu, Emmanuel ULiege; Prignon, Maxime ULiege; Servais, Christian ULiege et al

Conference (2019, May 23)

After several decades of sustained increase, hydrogen chloride (HCl, the main reservoir for stratospheric chlorine) showed a maximum abundance around 1997. Since then, its decrease has been documented ... [more ▼]

After several decades of sustained increase, hydrogen chloride (HCl, the main reservoir for stratospheric chlorine) showed a maximum abundance around 1997. Since then, its decrease has been documented, characterized by short-term variability which was attributed to atmospheric circulation changes, affecting mainly the lower stratosphere (Mahieu et al., 2014). This notably led to a temporary increase of HCl over 2007-2011, complicating the determination of the long-term HCl trend and the accurate verification of the success of the Montreal Protocol for the protection of the stratospheric ozone layer. Studies have used other long-lived tracers to remove the effects of dynamical variability in the lower stratosphere (e.g., Stolarski et al., 2018), while other investigations have suggested that trends in the upper stratosphere were potentially more appropriate for the long-term characterization of the HCl decrease (e.g., Froidevaux et al., 2015; Bernath and Fernando, 2018), especially when dealing with satellite height-resolved data. In this contribution, we use FTIR (Fourier Transform InfraRed) data from the Jungfraujoch station (Swiss Alps, 3580 m a.s.l.), a site of the NDACC network (http://www.ndacc.org), to study the evolution of HCl in some detail. The SFIT-4 retrieval algorithm implementing the Optimal Estimation Method of Rodgers (2000) is employed, providing HCl columns with good sensitivity from the tropopause up to about 40 km altitude. Moreover, the vertical resolution is sufficient to determine independent partial columns for the lower and upper stratosphere. With the support of model simulations performed with the 3D-Chemistry Transport Model of the Belgian Assimilation System for Chemical ObsErvations (BASCOE; Chabrillat et al., 2018), driven by the ERA-Interim meteorological reanalysis, we investigate the post-peak trend of HCl in the lower and upper stratosphere. We also determine the magnitude of the uncertainties affecting the various trends, using bootstrap tools which are specifically developed to take into account the auto-correlation present in our geophysical data sets. [less ▲]

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See detailPhotonic management using opal-like crystals in perovskite solar cells
Lobet, Michaël ULiege; Piron, Pierre ULiege; Dewalque, Jennifer ULiege et al

Conference (2019, May 22)

Perovskite solar cells recently showed a tremendous interest among the photovoltaic community. However, little is known on the effect of light management inside PV architectures. We compare structured and ... [more ▼]

Perovskite solar cells recently showed a tremendous interest among the photovoltaic community. However, little is known on the effect of light management inside PV architectures. We compare structured and unstructured absorbing layers in order to enhance the integrated quantum efficiency. The photo-active layer is made of monolayer, bilayer or trilayer of perovskite spheres inside a TiO2 matrix. The excitation of guided resonances via Fano resonances inside the absorbing spheres enhances the integrated quantum efficiency and enables a photonic gain as high as 6.4%. Influence of sphere's radius, incident angle and incident polarization on the absorbing properties are also reported. [less ▲]

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See detailMEMBRANE ESTROGEN RECEPTOR ALPHA PARTICIPATES IN THE ORGANIZATION OF THE BRAIN BY PERINATAL ESTROGENS
Cornil, Charlotte ULiege; Khbouz, Badr ULiege; Court, Lucas ULiege et al

Conference (2019, May 21)

Estrogens exert pleiotropic effects on multiple physiological and behavioral responses. Male and female sexual behaviors in rodents constitute some of the best characterized responses activated by ... [more ▼]

Estrogens exert pleiotropic effects on multiple physiological and behavioral responses. Male and female sexual behaviors in rodents constitute some of the best characterized responses activated by estrogens in adulthood and largely depend on estrogen receptor alpha (ERα). Evidence exists that nucleus- and membrane-initiated estrogen signaling cooperate to orchestrate the activation of these behaviors both short- and long-term. However questions remain regarding the mechanism(s) and receptor(s) involved in the early brain programming during development to organize the circuits underlying sexually differentiated endpoints. Taking advantage of a mouse model harboring a mutation of the ERα palmitoylation site which invalidates membrane ER signaling (mERα), this study investigated the role of mERα on the expression of male and female sexual behavior and neuronal populations that differ between sexes. The results revealed no effect of genotype on the expression of female sexual behavior while male sexual behavior was significantly reduced but not impaired in males homozygous for the mutation. Similarly, the number of kisspeptin- (Kp-ir) and calbindin-immunoreactive (Cb-ir) neurons in the anteroventral periventricular nucleus (AVPv) and the sexually-dimorphic nucleus of the preoptic area (SDN-POA) respectively were not different between genotypes in females, while homozygous males showed an increased number of Kp-ir and a decreased number of Cb-ir neurons compared to their wild-type littermates thus leading to an intermediate phenotype between females and wild-type males. Importantly, females treated with estrogens between post-natal day 0 and 5 exhibited the same neurochemical phenotype as their corresponding genotype in males. Together, these data provide evidence that mERα is involved in the perinatal programming of the male brain. [less ▲]

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See detailCE-MS/MS for bottom-up proteomics: comparaison of two coupling interfaces with ion mobility qTOF
Gou, Marie-Jia ULiege; Nys, Gwenaël ULiege; COBRAIVILLE, Gaël ULiege et al

Conference (2019, May 20)

Untargeted bottom-up proteomic analysis aims to identify the highest number of peptides from complex protein mixtures. As the samples are of high complexity and that some proteins can be at very low ... [more ▼]

Untargeted bottom-up proteomic analysis aims to identify the highest number of peptides from complex protein mixtures. As the samples are of high complexity and that some proteins can be at very low concentrations, efficient and sensitive instruments have to be used in order to maximize peptide identification. Nowadays, capillary electrophoresis tandem mass spectrometry (CE-MS/MS) has gained interest in proteomic analysis as it is considered as complementary to the gold standard method, namely reverse phase liquid chromatography tandem mass spectrometry (RP-LC-MS/MS). However, the coupling of CE with MS is not straightforward. Indeed robust interface is needed in order to conserve the high-resolution in-capillary separation while ensuring a stable spray. Among the commercialized interfaces, the coaxial sheath liquid interface (« Triple tube », Agilent Technologies) and the nanoflow sheath liquid interface (« EMASS-II », CMP Scientific) have been tested for the analysis of BSA and E. coli proteome digests. Both interfaces were coupled with an IMS-qTOF-MS. Several parameters were optimized in order to maximize the sensitivity, such as the composition of the sheath liquid and different pre-concentration approaches (stacking, dynamic pH junction and transient isotachophoresis). In our study, transient isotachophoresis (tITP) was selected among other techniques and allowed the injection of large sample volumes without sacrificing separation efficiency. At the end, spray stability was found as the main strength of the triple tube interface, whereas the EMASS-II interface was found to provide higher sensitivity thanks to the reduced flow rate of the sheath liquid. [less ▲]

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See detailSelf-health promotion and prevention by general practioners
Lenoir, Anne-Laure ULiege; Legrand, Charlotte

Conference (2019, May 20)

Introduction/Aim: The aim of this research was to compare the GPs' and the general population's behaviour in health promotion, prevention and seeing a GP. Method and results: All GPs from one district of ... [more ▼]

Introduction/Aim: The aim of this research was to compare the GPs' and the general population's behaviour in health promotion, prevention and seeing a GP. Method and results: All GPs from one district of French-speaking Belgium were asked to complete a 29-item questionnaire including questions about nutrition and sports habits, prevention acts and taking care of their own health. This questionnaire was based on the Health Survey of the Belgian Institute of Public Health. The first part of the analysis described the respondents’ answers. The second part compared the GPs’ results with the general population. 113 GPs participated in the study (response rate was 72.4%). Most GPs followed the recommendations about vaccination, cardiovascular and cancer screening, as well as alcohol and tobacco consumption. In contrast, most GPs did not follow the recommendations about nutrition. 51.0% of GPs had insufficient physical activity as compared to recommendations. Compared to the general population, GPs scored better concerning vaccination, cardiovascular and cancer screening, alcohol and tobacco consumption. In contrast, they had a lower score concerning intensive physical activity. No significant difference was found about nutrition (except lower consumption of dairy products). 31.0% of GPs had their own GP, compared to 94.0% of the general population. When feeling ill, most GPs used self-care and 4.4% did not treat themselves at all. 90.3% of GPs used self-prescription. Having a GP reduced significantly self-prescription and increased GP visits. Discussion and conclusions: This study showed that GPs care about prevention acts, but less about nutrition and sports habits. Seeing one’s own GP was unusual among GPs. This could lead to self-neglect and ignorance of early warning signs that that they would otherwise address if one of their patients was concerned. Promoting GPs’ self-health and encouraging them to see their own GP could improve their health condition. [less ▲]

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See detailPrinciples of Analytical Quality by Design for the development of quality control methods in a pharmaceutical context
Deidda, Riccardo ULiege; Avohou, Tonakpon Hermane ULiege; Jambo, Hugues ULiege et al

Conference (2019, May 20)

Pharmaceutical regulatory agencies increasingly require the implementation of systematic approaches covering the entire life-cycle of pharmaceutical products, from manufacturing processes to quality ... [more ▼]

Pharmaceutical regulatory agencies increasingly require the implementation of systematic approaches covering the entire life-cycle of pharmaceutical products, from manufacturing processes to quality control tests. In 2009, the International Council for Harmonisation (ICH) of technical requirements for pharmaceuticals for human use proposed a systematic approach named “Quality by Design” (QbD) to be implemented in the pharmaceutical field [1]. In this context, the QbD strategy have been progressively applied also to other aspects of the pharmaceutical chain, such as the analytical method development in quality control laboratories. The QbD applied to analytical chemistry is commonly named “Analytical Quality by Design” (AQbD) and in the last decade it has been widely applied in academia for the development of separation methods, involving different techniques such as LC, CE as well as SFC. However, its implementation in quality control laboratories still remains limited and then its advantages not completely exploited. Indeed, this approach presents a lot of conveniences, such as the deep knowledge acquired during the method development/optimisation by studying how critical method parameters (CMPs) affect critical method attributes (CMAs). Moreover, this strategy allows the possibility to define a method operable design region (MODR) consisting of a multitude of possible working points and for each of them a specific probability of success (π) is given. Indeed, the concept of risk plays a central role in this strategy as the MODR is considered of a zone of theoretical robustness limited by the so-called edges of failure, outside which the method performances are not accepted [2]. This presentation focuses first on the theoretical aspects regarding each step of this strategy. The analytical target profile definition, the selection of CMPs and CMAs, as well as screening and optimisation of CMPs and MODR definition are accurately described and illustrated. Some considerations about the choice of the working point, its validation and the planning of an efficient control strategy are also given. In the second part of this presentation all these concepts are once again showcased but from a practical point of view, by giving two concrete case-studies following the AQbD approach. The first one concerns the development of a liquid chromatography coupled to UV (LC-UV) method aimed at quantifying the cannabinoids content in cannabis extracts used for medicinal purposes [3]. The second one shows the approach applied to the development of a stability indicating method by using another analytical technique, the supercritical-fluid-chromatography coupled to mass spectrometry (SFC-MS). This latter is intended to be used for the quantification of hydro-soluble vitamins and amino acids in a complex medium. References [1] ICH Harmonised Tripartite guideline. Pharmaceutical Development Q8(R2) (2009) International Council for harmonisation of technical Requirements for Pharmaceutical for Human Use. [2] R. Deidda, S. Orlandini, Ph. Hubert, C. Hubert, Risk-based approach for method development in pharmaceutical quality control context: A critical review, J. Pharm. Biomed. Anal. 161 (2018) 110-121. [3] R. Deidda, H.T. Avohou, R. Baronti, P.L. Davolio, B. Pasquini, M. Del Bubba, C. Hubert, Ph. Hubert, S. Orlandini, S. Furlanetto, Analytical quality by design: Development and control strategy for a LC method to evaluate the cannabinoids content in cannabis olive oil extracts, J. Pharm. Biomed. Anal. 166 (2019) 326-335. [less ▲]

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See detailOptimisation of the separation of therapeutic phosphorothioate oligonucleotides by hydrophilic interaction liquid chromatography and capillary zone electrophoresis.
Demelenne, Alice ULiege; Gou, Marie-Jia ULiege; Parulski, Chloé et al

Conference (2019, May 20)

Introduction: Therapeutic oligonucleotides are short nucleic acids chemically synthetized that play a major role in gene regulation and the treatment of various diseases. They can target DNA, RNA ... [more ▼]

Introduction: Therapeutic oligonucleotides are short nucleic acids chemically synthetized that play a major role in gene regulation and the treatment of various diseases. They can target DNA, RNA, proteins, posttranslational protein modifications, carbohydrates, lipids or metabolites. Oligonucleotides are easily in-vivo degraded and need to be modified to improve their pharmacokinetic and pharmacodynamics properties. Phosphorothioate oligonucleotides (PS ON) is the most dominating modification where the oxygen atom of the phosphodiester bond is replaced by a sulfur atom. This result in enhanced resistance against nucleases degradation and thus increased half-life. Goals: Since many therapeutic oligonucleotides are arriving on the global market, there is an important need for appropriate analytical techniques to ensure their quality control. In this work, we optimized hydrophilic interaction liquid chromatography and capillary zone electrophoresis methods to detect PS ON impurities. Material and methods: Two complex mixtures were used to optimize the separation methods. Firstly, a mixture containing short PS ON of identical sequence varying by the position of the phosphodiester bonds will be analyzed. Secondly, a mixture of 20 PS ON of different lengths and thus different number of PS linkages will be used. Results and discussions: In hydrophilic interaction liquid chromatography, the stationary phase composition and the mobile phase composition and gradient were carefully optimized. In capillary zone electrophoresis, the pH and molarity of the background electrolyte will be studied. The final developed methods were compared in terms of peak efficiency, resolution and analysis time. The advantages and disadvantages related to each technique will be discussed. Conclusions: We demonstrated that hydrophilic interaction liquid chromatography and capillary electrophoresis are suitable techniques to differentiate closely related PS ON and could easily be applied for the quality control of those emerging medicines. [less ▲]

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See detailMesoporous silica impregnation using supercritical carbon dioxide: is the solubility in the supercritical fluid a critical parameter?
Koch, Nathan ULiege; Jennotte, Olivier ULiege; Rocks, Natacha ULiege et al

Conference (2019, May 20)

Recently, mesoporous silica (MS) has been used as a material able to maintain amorphous state of active pharmaceutical ingredients (APIs) due to appropriate pore size and pore morphologies. Among the ... [more ▼]

Recently, mesoporous silica (MS) has been used as a material able to maintain amorphous state of active pharmaceutical ingredients (APIs) due to appropriate pore size and pore morphologies. Among the impregnation methods of MS, techniques using supercritical carbon dioxide (sc-CO2) are promising tools since they provide many advantages, such as the ability to produce a final medicine without any residual toxic material. Solubility of the API in sc-CO2 is reported as one of the most critical parameters, which usually limits its use in drug formulation. Most of APIs have a poor solubility in sc-CO2 and the use of organic solvents is often required1,2. The goal of this study is to evaluate the feasibility of using sc-CO2 techniques for the impregnation of MS by APIs insoluble in sc-CO2. To do so, fenofibrate (FF) is used as model drug since by changing pressure and temperature conditions of the equipment, FF can be either soluble in sc-CO2 or not soluble but molten in the supercritical phase3. FF-MS complexes were produced by four different methods. Physical mixture (PM) composed of FF (70%, 50%, 43% and 41%) and MS were produced using a mixer during 15 minutes. Fusion at atmospheric pressure inclusion was performed in a water bath by keeping PM at a temperature above the fenofibrate melting point during 1h. Supercritical method with dissolved FF was performed by placing PM in a high pressure reactor for 1 hour under supercritical conditions (40°C and minimum 140 bars) leading to the dissolution of FF in sc-CO2 while supercritical method with melted FF was perfomed under supercritical conditions (60°C and 90 bars) leading to the melting but not to the dissolution of FF in sc-CO2. FF-MS complexes were characterized in terms of drug loading by high performance liquid chromatography, in terms of crystallinity by differential scanning calorimetry and in terms of dissolution profile by an appropriate in vitro dissolution test. We have shown that the use of sc-CO2 as fusion medium allows to work with lower temperature and an increased drug loading and homogeneity in comparison with classical melting inclusion methods. FF-MS formulations produced with sc-CO2 as fusion medium give similar crystallinity and dissolution results compare to those produced with supercritical fluids as solvent. Through this study, we show new possibilities of using sc-CO2 for APIs insoluble in this fluid. [less ▲]

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See detailDevelopment of new manufacturing processes for amorphous solid dispersions
Jennotte, Olivier ULiege; Koch, Nathan ULiege; Rocks, Natacha ULiege et al

Conference (2019, May 20)

Use of the hot-melt extrusion form amorphous solid dispersions of atorvastatin calcium trihydrate with a selection of three polymers in order to enhance its aqueous solubility

Detailed reference viewed: 22 (4 ULiège)
See detailMagnetic flux penetration in superconducting films with border defects
Vanderheyden, Benoît ULiege; Avila Osses, Jonathan ULiege; Brisbois, Jérémy ULiege et al

Conference (2019, May 20)

Defects can have a large impact on the magnetic response of superconducting thin films by forcing changes in the path of the induced electrical currents. When the magnetic flux creep exponent is high, the ... [more ▼]

Defects can have a large impact on the magnetic response of superconducting thin films by forcing changes in the path of the induced electrical currents. When the magnetic flux creep exponent is high, the associated perturbation is typically damped over a distance that can largely exceed the size of the defects. The current flow is then reorganized in large domains with different orientations of the electrical current density, separated by narrow domain walls. In the critical state limit with an infinite creep exponent, the domain walls degenerate into discontinuity lines, or d-lines. In this talk, I consider the penetration of magnetic flux perpendicularly to a Nb superconducting film containing edge indentations and/or defects. It has recently been shown, by means of magneto-optical imaging and numerical simulations, that the detailed shape of the d-lines generated by lithographically-defined micro-indentations carry information about their size and shape, and vary with temperature [1]. In this talk, I examine macroscopic models, constructed over length scales of many vortices, which can be used to describe the d-lines. I discuss the effects of temperature, demagnetization, and flux creep, as well as the influence of a field-dependent critical current density on the distribution of the magnetic field. The models are applied to both indentations and defects arising from inhomogeneous properties of the film. A comparison between the model predictions and the experimental data points to the importance of a lowered surface barrier in the presence of the defects. It is argued that indentations and defects help in releasing the magnetic flux pressure, and, thereby, help in avoiding thermomagnetic instabilities. [less ▲]

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See detailLa qualité de vie des enfants à l'entrée à l'école maternelle ?
Housen, Marie ULiege; Pirard, Florence ULiege

Conference (2019, May 20)

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See detailHANDHELD RAMAN SPECTROSCOPY: AN ESSENTIAL TOOL TO TACKLE THE SUBSTANDARD MEDICINES ISSUE?
Coic, Laureen ULiege; Sacre, Pierre-Yves ULiege; Dispas, Amandine ULiege et al

Conference (2019, May 20)

According to the World Health Organization, there is a growing concern about the quality of medicines around the world. Indeed, more and more substandard and falsified medicines are identified. That is ... [more ▼]

According to the World Health Organization, there is a growing concern about the quality of medicines around the world. Indeed, more and more substandard and falsified medicines are identified. That is why several spectroscopic techniques such as Raman, near- or mid-infrared spectroscopy, have gained great interest for this purpose. By means of chemometrics, interesting results have been shown in terms of elucidation of falsified medicines composition by hyperspectral imaging (L. Coic) and with benchtop spectrophotometers (O.Ye. Rodionova). However, these instruments are rather expensive, heavy and are not appropriated for low and middle-income countries. To circumvent these issues, several low-cost and middle-cost handheld spectrophotometers have been developed. In some cases of falsification, there is presence of a wrong or an absence of active pharmaceutical ingredient (API) that is often easy to prove with spectroscopy. However, the major part of the burden is constituted of lower dosed API that is trickier to evaluate in the field with conventional tools. In this study, the potential of handheld Raman spectroscopy to assay API in a solid dosage form was evaluated. For this purpose, fifteen formulations with a various proportion of mannitol and microcrystalline cellulose, seven level of concentration of ibuprofen (14 % – 26 % (m/m)) were produced thanks to a design of experiments, following the ICH Q3 guidelines. The calibration set was realized by analysing 3 tablets per formulation and each tablet was assayed using a previously validated benchtop NIR model. The PLS model was developed using PLS-Toolbox running in a Matlab® environment. The PLS model calibration has shown very nice results, with a R² of calibration / R² of cross-validation of 0.981 / 0.968 and a RMSECV of 0.83% (m/m). As explained, the validation set was projected on model and showed a RMSEP of 0.89 % (m/m). Then, the quantitative model has been validated following the total error approach with 4 series, 5 levels of concentration and 3 replicates. The acceptance limits were set at +/-15 % following the European Pharmacopeia criteria for uniformity of content. In a nutshell, handheld Raman spectrophotometer has shown very interesting results for studied formulation. Thanks to the 14 – 26 % (m/m) range, the model could be applied to get the quantitative information of the dosage of substandard medicines on the field. [less ▲]

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See detailField survey to evaluate the prevalence of poor quality anti-infective medicines in Cameroon
Waffo Tchounga, Christelle Ange ULiege; Ciza Hamuli, Patient ULiege; Sacre, Pierre-Yves ULiege et al

Conference (2019, May 20)

Poor quality medicines pose a threat to all health systems. It is obvious that they have harmful consequences not only from the point of view of public health, but also from the economic and socio ... [more ▼]

Poor quality medicines pose a threat to all health systems. It is obvious that they have harmful consequences not only from the point of view of public health, but also from the economic and socio-economic point of view [1]. Over the past 15 years, substandards and falsified drugs have received increasing attention in scientific publications. However, there is little reliable data determining their prevalence with accuracy due to the scarcity of well-designed studies identified as having good methodological quality as well as representative sampling strategy [2-4]. In this context, we have decided to evaluate the prevalence of poor quality anti-infective medicines in two Cameroon areas (Yaoundé and Douala), inspired by the Medicines Quality Assessment Reporting Guidelines (MEDGUARG) [3] and WHO recommendations [4] for the sampling strategy and the methodology. Our study will focus on the formal private sector. Pharmacies as well as drugs products will be sampled by a stratified random sampling strategy. The study will focus on two anti-infective medicines (ciprofloxacin and metronidazole 500mg tablets) in tablets, from 96 outlets in the cities of Yaoundé and Douala that are the two main cities (Yaoundé and Douala) of Cameroon representing almost 70% of private outlets of the country. Mystery shoppers will collect samples using a specific scenario. As a prelude to our field study, screening and dosage methods have to be developed and validated in Liège University. They se methods consist of vibrational spectroscopy (near infrared and Raman spectroscopy) as first screening techniques and HPLC for identification and assay. For vibrational spectroscopy, qualitative models will be developed for identification using chemometric tools. HPLC methods will be validated following the total error approach using accuracy profile as decision tool. The medicines collected will be first analysed visually (physical appearance tests), then field methods will be implemented (screening methods: Paper Analytical Devices (PADs), handled NIR device). Finally laboratory testing (assay and confirmation methods: HPLC reference method and pharmacotechnical tests) will be performed at LANACOME (Yaoundé, Cameroon). Suspect and unusual samples will be transported to Liège University for further analyses. All these methods will be applied according to a decision tree based on observed facts. The study will be submitted to the ethics committee of the Ministry of Health in Cameroon. An accurate and fast HPLC method for identification and quantification of both metronidazole and ciprofloxacin has been developed. Identification models for some brands of ciprofloxacin and metronidazole using handled NIR and Raman devices has been developed before implementation on field. This study will allow us to evaluate not only the prevalence of poor quality anti-infective medicines marketed in Cameroon but also outlets dispensing substandard and falsified medicines. They will be distinguished into sub-standard, degraded or falsified and classified according to their country of origin, manufacturer and city of sampling. The results will be notified to the drug regulatory authority in Cameroon and if poor quality medicines are detected, we will proceed with an alert to the WHO Global Surveillance System. The estimation of the prevalence of counterfeit and falsified anti-infective medicines would be extrapolated to the entire population and depending on the information obtained, evaluate the patient health risk exposed to substandard and falsified anti-infective medicines and develop capacity-building interventions in the fight against poor quality medicines. [less ▲]

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See detailAu-delà des mots: évaluer la qualité de vie chez les enfants qui bégaient
Leclercq, Anne-Lise ULiege; Gantier, Pauline; Moïse-Richard, Anne

Conference (2019, May 20)

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Peer Reviewed
See detailCancer stem cells in HPV-related cancer
Herfs, Michael ULiege

Conference (2019, May 18)

Detailed reference viewed: 3 (1 ULiège)
Peer Reviewed
See detailFirm productivity and territorial resources: Evidence from Wallonia (Belgium)
Wilmotte, Pierre-François ULiege; Dejardin, Marcus; Van Caillie, Didier ULiege et al

Conference (2019, May 17)

The aim of our presentation is to expose some territorial evidence from a model explaining the firm productivity in Wallonia, the Southern region of Belgium. This model is a part of our PhD-thesis project ... [more ▼]

The aim of our presentation is to expose some territorial evidence from a model explaining the firm productivity in Wallonia, the Southern region of Belgium. This model is a part of our PhD-thesis project aiming to estimate the impact of the territorial resources on the firm performance in Wallonia. Like many other European regions, Wallonia faces up to some challenges related to the regional development: firm location is largely structured by agglomeration economies, generating some economic disparities across the region, but public policies in the regional development field are more focused on infrastructure and inexpensive land supply for some decades (Gouvernement wallon, 2014; Vandermeer, 2016; Wilmotte & Halleux, 2018). We have developed an econometric model in order to explain the productivity of Walloon SMEs by the intern feature of the firm provided thanks to accounting data and by the access to the territorial resources. By territorial resources, we mean the specific features of the territories that affect the ability of companies to develop their business. Our model illustrates the impact of several territorial resources with a multi-scale effects: the importance of location at European market scale, the effect of proximity to the first-rank cities (and not to the second-rank cities in the Walloon study case) et the lower impact of local infrastructures for the firm productivity. These results provide some contributions to the debate for regional development with the key role of agglomeration economies for the SMEs performance. [less ▲]

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See detailIdentification of Signaling Pathways regulating beta cell regeneration
Massoz, Laura ULiege; Manfroid, Isabelle ULiege

Conference (2019, May 17)

Detailed reference viewed: 11 (1 ULiège)
See detailNumeration systems with alternating real bases
Cisternino, Célia ULiege

Conference (2019, May 17)

During this presentatation, I introduice the new theory of the alternate bases. In this generalization of the beta-expansions, we use a p-tuple B₁,B₂,…,Bp as a base to represent any real number in [0,1 ... [more ▼]

During this presentatation, I introduice the new theory of the alternate bases. In this generalization of the beta-expansions, we use a p-tuple B₁,B₂,…,Bp as a base to represent any real number in [0,1]. Some properties are stated and so is the generalization of Parry's Theorem. Moreover, the subshift associated with the alternate bases is studied. [less ▲]

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See detailInformal tourist accommodation: geographic and ethical issues
Nyns, Symi ULiege; Schmitz, Serge ULiege

Conference (2019, May 17)

Tourism development is transforming the face and the organisation of many cities and countryside. The number of tourists increases, generating huge concentrations in some places and a spread of places ... [more ▼]

Tourism development is transforming the face and the organisation of many cities and countryside. The number of tourists increases, generating huge concentrations in some places and a spread of places visited and accommodation. Tourism is undergoing major changes because of the volume of innovations that are intended for it. Approach as a vector of development, tourism sets off many questions as to how it is redesigned and decided. The sharing economy is part of these innovations. This research focuses on the implications of the collaborative economy for tourism and destinations. While several research highlight the economic and social impacts related to the “new” accommodation, the knowledge of the distribution of overnights stays is currently falsified because national organisms fail to take into account the huge diversity of alternative accommodation. Wallonia, as case study, offers a diversity of destinations linked to the proximity of Brussels, historical cities, forest areas and gastronomy. To understand the influences of the development of “new” accommodation on host communities, a first step should to study their location and spatial expansion schemes. First, the databases relating to exchange platforms (Housetrip, AirDNA, HomeAway...) are consulted as well as official statistics of tourism. Secondly, these data are compared with the location data from mobile telephony. In accordance with the General Protection Regulations, a query was constructed to identify tourist overnights. The paper shows the first maps and reflects on the ethical use of the data for the research and of the use of ITC to circumvent the official accommodation. [less ▲]

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See detailCyanobacteria and their toxins
Wilmotte, Annick ULiege

Conference (2019, May 16)

- Evolution and morphology - Ecology - Metabolism - Cellular differentiation (heterocysts, akinetes) - Gas vesicles - Production bioactive compounds - Source of proteins and biotechnological compounds ... [more ▼]

- Evolution and morphology - Ecology - Metabolism - Cellular differentiation (heterocysts, akinetes) - Gas vesicles - Production bioactive compounds - Source of proteins and biotechnological compounds - Our research on Belgian planktonic cyanobacteria: B-BLOOMS [less ▲]

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See detailDispositif de suivi personnalisé des étudiants en biologie bloc 1
Rigo, Pierre ULiege; Thiry, Marc ULiege

Conference (2019, May 16)

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Peer Reviewed
See detailBanalité, délégitimation, oubli : des conditions du ratage en littérature
Stienon, Valérie ULiege

Conference (2019, May 16)

L’échec gagne à être considéré autrement que par défaut, comme une absence de réussite. Tout particulièrement en littérature, où il a une rentabilité particulière, selon les époques et les configurations ... [more ▼]

L’échec gagne à être considéré autrement que par défaut, comme une absence de réussite. Tout particulièrement en littérature, où il a une rentabilité particulière, selon les époques et les configurations du champ, qui peuvent opérer un renversement et motiver une lecture valorisante de réhabilitation ou de redécouverte. Mais peut-on pour autant le définir positivement, en propre ? Il semble réunir une double dimension: empirique de tentative effective, et déclarative de formulation d’un projet. Or, on sait combien il est difficile en littérature de faire la part du discours et de l’acte. Par ailleurs, que signifie essayer, en littérature : être passé par le dispositif éditorial, avoir été lu par un public, avoir reçu un jugement négatif, avoir été entravé dans une trajectoire naissante, y avoir mis fin soi-même, ou encore avoir été effacé par le temps, après avoir réalisé une trajectoire de plus ou moins grande envergure ? Comme l’échec touche de près aux différentes modalités d’attribution ou d’obtention de la valeur dans le champ littéraire, il importe de se donner les moyens de le considérer sur chacun des plans économique, symbolique et relationnel. La communication propose d'aborder ces aspects pour rendre compte d'un phénomène multifactoriel et complexe. [less ▲]

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See detailPrise en charge de l'entorse de cheville
Aguilaniu, Aude ULiege

Conference (2019, May 16)

Ankle sprain is common and the recurrence rate is high. Evaluation of ankle sprain is often subjective. This presentation highlights that valid and reproducible objective methods exist. In a second step ... [more ▼]

Ankle sprain is common and the recurrence rate is high. Evaluation of ankle sprain is often subjective. This presentation highlights that valid and reproducible objective methods exist. In a second step, we approach the rehabilitation tools that allow destabilization along the inversion axis are various. Each has its advantages and disadvantages. [less ▲]

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See detailUrolithiasis in beef cattle: from diagnosis to prevention
Sartelet, Arnaud ULiege

Conference (2019, May 16)

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See detailSingle center experience in 157 controlled DCD-liver tranplantation
Schielke, Astrid Anita ULiege; Paolucci, M; MEURISSE, Nicolas ULiege et al

Conference (2019, May 16)

Introduction: Donation after circulatory death (DCD) have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of graft loss and ... [more ▼]

Introduction: Donation after circulatory death (DCD) have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of graft loss and retransplantation. The authors retrospectively reviewed a single centre experience with controlled DCD-LT in a 15-year period. Patients and Methods: 157 DCD-LT were consecutively performed between 2003 and 2017. All donation and procurement procedures were performed as controlled DCD in the operating theatre. Data are presented as median (ranges). Median donor age was 57 years (16-83). Median DRI was 2.242 (1.322-3.554). Allocation was centre-based. Median recipient MELD score at LT was 15 (6-40). Mean follow-up was 37 months. No patient was lost to follow-up. Results: Median total DCD warm ischemia was 19 min (7-39). Median total ischemia was 313 min (181-586). Patient survivals were 89.8%, 75.5% and 73.1% at 1,3 and 5 years, respectively. Graft survivals were 89%, 73.8% and 69.8% at 1,3 and 5 years, respectively. Biliary complications included mainly anastomotic strictures, that were managed either by endoscopy or hepatico- jejunostomy. Two patients were retransplanted due to intrahepatic ischemic lesions. Conclusion: In this series, DCD LT provides results similar to classical LT. Short cold ischemia and recipient selection with low MELD score may be the keys to good results in DCD LT, in terms of graft survival and avoidance of ischemic cholangiopathy. [less ▲]

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See detailClinical outcomes of DCD type V liver transplantation: donation after euthanasia
van Reeven, M; Monbaliu, D; van Leeuwen, Olivier et al

Conference (2019, May 16)

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See detailIs an expert-based model able to map erosion in an agricultural catchment?
Cantreul, Vincent ULiege; Bielders, Charles; Swerts, Gilles ULiege et al

Conference (2019, May 16)

Intensive agricultural practices on sensitive soils induce high erosion rates in central Belgium. Expert-rules models quantify runoff and erosion at watershed scale avoiding over-parameterization. The aim ... [more ▼]

Intensive agricultural practices on sensitive soils induce high erosion rates in central Belgium. Expert-rules models quantify runoff and erosion at watershed scale avoiding over-parameterization. The aim of this study is to test the ability of an expert-based model, LandSoil, to quantify runoff and to locate erosion and deposition areas in a small agricultural watershed in Belgium. For that purpose, Chastre catchment behavior is modeled using LandSoil during 3 years. Measurements of runoff and observation of spatial erosion/deposition patterns permit to assess the reliability of the model. Runoff modeling gives satisfactory results with good linear adjustments (r² of 0.94, Nash-Sutcliffe criterion of 0.92). However, 3 events tend to greatly overestimate runoff production. Graduated rulers and runoff samplings demonstrate that the model is able to provide a coherent pattern of erosion/deposition. The study highlights more sensitive effect of land use compared to landscape design. Grass strips induce a deposition of eroded particles when slopes are gentle (<2%), wood strip decreases connectivity by cutting erosion stream and deposit thicker sediment layers (up to 5 cm). This modeling validation in the Belgian loess context allows us to use expert based models in other similar environments and to estimate the effect of landscape management scenarios. [less ▲]

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See detailPlankton Data Products
Barth, Alexander ULiege; Beauchard, Olivier; Herman, Peter et al

Conference (2019, May 15)

Detailed reference viewed: 22 (4 ULiège)
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See detailOpening general session - The CoToCoCo project : a Conceptual Toolkit for Contemporary Conservation
Houbart, Claudine ULiege; Dawans, Stéphane ULiege; Verbeeck, Muriel ULiege

Conference (2019, May 15)

Since the mid-twentieth century, theoretical and practical approaches to heritage have caught the interest of a growing number of academic and professionals. Facing the expanding scope of what an always ... [more ▼]

Since the mid-twentieth century, theoretical and practical approaches to heritage have caught the interest of a growing number of academic and professionals. Facing the expanding scope of what an always larger diversity of stakeholders consider necessary to hand in to the future, guidelines, sets of principles, charters and recommendations have multiplied in order to address each and every challenge posed by this ever-expanding corpus and its very diverse public. At the same time, the globalisation of heritage debates starting, in the field of architecture, which the Athens Conference in 1931 and booming with the World Heritage Convention, has questioned the most deeply rooted cultural traditions on which conservation and restoration principles had been built and developed. Despite some attempts to organise this prolific production and these fundamental questionings into a coherent theory (Munos-Vinas, 2003), experience shows that in front of practical problems, practitioners tend to come back to some fundamentals – the Venice Charter in architecture, Cesare Brandi’s theory in art, for example – despite the anachronism of using them to answer questions which couldn’t be foreseen at the time when they were thought. In parallel, a tendency to decontextualise practices, extracted from their traditional background, regularly helps to argue in favour of projects aiming at sustaining the capitalistic machine or questionable political interests rather that the safeguard and transmission of heritage (using the periodic rebuilding of Shinto temples to justify the rebuilding of any monument in the world is the clearest example). In this context, blurred interpretations of the concepts of identity and authenticity are in many cases responsible for a confusion in the debates and lead to unsatisfactory compromises mostly in disfavour the safeguard of heritage. At the same time, the expansion and diversification of cultural goods contributes in a positive way to a renewal of conservation and restoration approaches. Our ambition is to conjointly revitalize reflections on movable and immovable cultural goods, proposing methodological tools and ressources for a interdisciplinary dialogue in a broad sense. The CoToCoCo project (Conceptual Tools for Contemporary Conservation) is based on borrowings from varied disciplines – sociology, anthropology, mathematics, philosophy, semiology – in order to draw alternative perspectives and submit them for practitioner’s consideration. For this conference, we will provide an example of our methodology and its practical application, starting from a text by the French sociologist Nathalie Heinich on “heritage emotions”. We will submit it to the reflection of two heritage professionals – a conservator of cultural goods, working with communities in Central America and an Irish architect, in order to demonstrate that in order to think “out of the box”, it is sometimes necessary to rejuvenate theory and to try it out just like any other practical tool. [less ▲]

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See detailConclusions
Cormann, Grégory ULiege

Conference (2019, May 14)

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See detailQuels facteurs individuels peuvent prédire la charge vocale des enseignants ?
Remacle, Angélique ULiege; De Chambourcy, Laetitia; Lefèvre, Nathalie

Conference (2019, May 14)

Introduction : Au cours de leur carrière, plus de la moitié des enseignants développent des troubles de la voix (Van Houtte et al., 2011). Il s’agit principalement de phonotraumatismes consécutifs à une ... [more ▼]

Introduction : Au cours de leur carrière, plus de la moitié des enseignants développent des troubles de la voix (Van Houtte et al., 2011). Il s’agit principalement de phonotraumatismes consécutifs à une surcharge vocale, favorisant des patterns phonatoires dysfonctionnels (Martins et al., 2014). Ce travail vise à identifier les facteurs individuels qui prédisent l’augmentation de la charge vocale. Méthode : 87 enseignants ont porté un dosimètre durant une semaine de travail (Figure 1). Ce dispositif permet le monitoring du comportement phonatoire à l’aide d’un capteur de vibration des plis vocaux. Les paramètres de charge vocale analysés toutes les 200 ms sont : la durée de phonation, l’intensité et la fréquence fondamentale de la voix (F0). Les caractéristiques individuelles suivantes des participants ont été étudiées : genre, âge, nombre d’années de carrière dans l’enseignement, niveau enseigné (Tableau 1), consommation de tabac, présence de problèmes gastro-œsophagiens, pratique d’un loisir sollicitant l’usage de la voix, éducation vocale, problèmes vocaux passés, présence de plaintes vocales au moment de l’étude évaluée avec le Voice Handicap Index (VHI) (Woisard et al., 2004). Afin de déterminer l’effet des facteurs individuels sur les paramètres de charge vocale, des modèles linéaires mixtes ont été utilisés. Résultats : Aucun facteurs individuel n’influence la durée de phonation ni l’intensité vocale. Par contre, F0 dépend significativement du genre, du niveau enseigné, de la pratique d’un loisir sollicitant l’usage de la voix, et du score au VHI. Plus précisément, F0 est plus élevée pour les femmes que les hommes (Δ=68 Hz), pour les individus ne pratiquant pas de loisir vocal (Δ=10 Hz), et pour ceux ayant un score élevé au VHI (augmentation de 0,7 Hz pour chaque point supplémentaire au VHI). Le niveau enseigné impacte la F0 des femmes uniquement. Les enseignantes des universités ont une voix plus grave que celles du maternel (Δ=58 Hz), du primaire (Δ=44 Hz), et du secondaire (Δ=31 Hz). Conclusions : Sachant que l’élévation de F0 augmente les stress mécaniques liés à la vibration, les individus à risque de phonotraumatismes sont les femmes et particulièrement celles qui enseignent dans les niveaux inférieurs, ainsi que les enseignants auto-rapportant des plaintes vocales. La voix plus grave des participants ayant une activité extra-professionnelle vocale pourrait s’expliquer par une inflammation aigue ou une fatigue musculaire liée à la surcharge vocale (Remacle et al., 2018). Ces informations aident à identifier les enseignants à cibler dans les programmes de dépistage et de prévention des problèmes vocaux. [less ▲]

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See detailA multifaceted approach of dating violence among adolescents and emerging adults
Courtain, Audrey ULiege; Glowacz, Fabienne ULiege

Conference (2019, May 14)

Romantic relationships contribute to the development of adolescents and emerging adults. A growing literature has studied violence occurring between dating partners: dating violence (DV) raises concerns ... [more ▼]

Romantic relationships contribute to the development of adolescents and emerging adults. A growing literature has studied violence occurring between dating partners: dating violence (DV) raises concerns for the well-being of youth. Following a multifaceted approach, the present research aims to examine individual variables associated with DV. A sample made up of 1811 students - from secondary schools (mean age = 17.3, σ =0.86) and a college (mean age = 19.9, σ =2.11) - was self-administered validated questionnaires investigating perpetration/victimization of DV, attitudes toward DV, empathy, impulsivity, language and alcohol use. Results show patterns of gender symmetry, multiperpetration/multivictimization and bidirectionality. Attitudes toward DV are associated with the perpetration/victimization of DV (both face-to-face and online DV). Males’ attitudes are more in favor of DV than females’. Female-perpetrated physical and sexual DV are more accepted than male-perpetrated ones. Several dimensions of empathy and language are negatively associated with DV perpetration, while several dimensions of impulsivity are positively associated with DV perpetration. As for alcohol, higher scores of hazardous drinking puts at risk of insulting a dating partner or being insulted by a dating partner in a context of alcohol use. This research can contribute to the development of multifaceted prevention programs among youth. [less ▲]

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See detailReal enough: A virtual classroom can induce an increase in anxiety and speech disfluencies in adolescents
Leclercq, Anne-Lise ULiege; Duwernell, Céline; Delaite, Ophélie et al

Conference (2019, May 14)

Virtual reality (VR) enables the user to navigate and interact in real time with computer-generated 3D environments. There is an increasing interest in using virtual environments to study psychological ... [more ▼]

Virtual reality (VR) enables the user to navigate and interact in real time with computer-generated 3D environments. There is an increasing interest in using virtual environments to study psychological phenomena such as anxiety (Wiederhold & Bouchard, 2014). In this study, we assess the feasibility of a virtual classroom to evoke anxiety and speech disfluencies in adolescents. Twenty adolescents who do not stutter or suffer from social anxiety disorder, were asked to talk for approximately four minutes in front of the examiner, in a virtual classroom and in a VR neutral environment. They repeatedly rated their level of anxiety while speaking. Our results show an increase in speech disfluencies when speaking in front of a virtual classroom compared with speaking to the examiner. Moreover, we observed higher levels of anxiety when speaking in a virtual classroom than when speaking in an empty apartment. These preliminary results underline the capacity of a virtual classroom to induce anxiety and speech disfluencies in youth. These results, alongside previous research into adults (Brundage & Hancock, 2015; Brundage et al., 2006, 2016), are encouraging for the clinical use of VR environments to assess and treat anxiety and speech disfluencies in people who stutter. [less ▲]

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See detailClinical usefulness of virtual reality: Illustration through case studies
Wagener, Aurélie ULiege

Conference (2019, May 14)

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See detailThe emergence and evolution of ageist stereotypes in children
Flamion, Allison ULiege

Conference (2019, May 14)

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See detailMinor plant species can be key players of the Poaceae virome at the agroecosystem scale.
Maclot, François ULiege; Candresse, Thierry; Filloux, Denis et al

Conference (2019, May 13)

Prior to the domestication of plants, it is hypothesized that plant viruses were co-evolving with uncultivated plants growing in mixed species communities, which probably resulted in complex interactions ... [more ▼]

Prior to the domestication of plants, it is hypothesized that plant viruses were co-evolving with uncultivated plants growing in mixed species communities, which probably resulted in complex interactions (antagonism, commensalism, mutualism). The development of agriculture further deeply modified natural ecosystems and land use, creating agroecosystems composed by both cultivated and uncultivated areas. It is postulated that the advent of agriculture has modified the dynamics of virus-plant interactions, which has fostered the occurrence of virus disease emergence events. At the level of natural ecosystems, the relationships between plant communities’ diversity and plant virus diversity, the distribution of plant viruses and the interactions between viruses and their uncultivated hosts, have just started to be explored. In this context, we are conducting a study in the Natural Park “Burdinale-Mehaigne” (Belgium) using high throughput sequencing technologies in order to characterize the virome of Poaceae communities, including minor species, in contrasted agricultural ecosystems (cereal monocultures, grazed pastures and natural grasslands). We adapted a virion-associated nucleic acids (VANA) metagenomics protocol to sequence at high throughput pools of 50 plant samples per ecosystem (50 samples reflecting plant species composition) and per plant species. Over two years, about 4,300 Poaceae plants (corresponding to 24 species) were sampled and processed using the VANA metagenomics approach. The bioinformatic analyses revealed the presence of diverse viral communities in wild and cultivated Poaceae, even though they did not present any symptoms. These viruses belong to diverse families (e.g. Endornaviridae, Luteoviridae, Partitiviridae, Potyviridae, Reoviridae, Secoviridae), infecting a large range of hosts within the Poaceae and transmitted by different vectors (aphids, planthoppers, mites, nematods) or seed-borne. Interestingly, minor Poaceae species studied in grasslands contained a wide virus richness, sometimes greater than ecosystemic pools containing 8-11 major plant species. Moreover, some virus genera (e.g. Amalgavirus, Alphaendornavirus, Potyvirus, Sobemovirus) were found only in minor species, underlining the importance of minor plant species as virus reservoirs in wild ecosystems such as grasslands. [less ▲]

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See detailAgent double : du recours au récit dans l'administration de l'anticipation
Claisse, Frédéric ULiege

Conference (2019, May 13)

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See detailRecherche doctorale : présentation
Outers, Pierre ULiege

Conference (2019, May 13)

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See detailTendinopathies, ce qu’il ne faut faire et ne pas faire
Kaux, Jean-François ULiege

Conference (2019, May 12)

Le médecin généraliste est souvent confronté aux tendinopathies. Leurs nombreuses formes ou localisations compliquent sa tâche lorsqu’il faut décider du traitement adéquat. La compréhension de la ... [more ▼]

Le médecin généraliste est souvent confronté aux tendinopathies. Leurs nombreuses formes ou localisations compliquent sa tâche lorsqu’il faut décider du traitement adéquat. La compréhension de la pathologie tendineuse par le modèle du continuum de Cook et Purdam, ainsi que la notion d’hétérogénéité ont permis de proposer des stratégies thérapeutiques, adaptées aux différents phénotypes. Dans un premier temps, il est essentiel d’obtenir une antalgie satisfaisante et de la poursuivre dans un second temps par une rééducation physique, associée ou non à un traitement biologique, tel que les ondes de choc ou l’injection de plasma riche en plaquettes, stimulant la régénération. L’objectif étant d’obtenir une récupération optimale en terme de douleur et de fonctionnalité ainsi que de limiter les récidives. À l’aide de l’analyse et de la compréhension de l’évolution de la tendinopathie à travers les 3 stades ainsi que les mécanismes d’action des différents traitements, il est possible de poser les indications thérapeutiques les plus adaptées. Dans leurs études Cook et Purdam divisent leur modèle de continuum en plusieurs catégories thérapeutiques : • réactionnelle et début des remaniements structurels « early disrepair » ; • remaniements structurels avancés « late disrepair » et remaniements dégénératifs. Early disrepair (stade réactionnel et début desremaniements) Dans la première catégorie, nous allons nous orienter vers des traitements antalgiques et anti-inflammatoires qui vont diminuer la prolifération cellulaire et la synthèse protéique, afin de renverser les mécanismes liés à la surcharge. Il est impératif de diminuer la charge à laquelle le tendon est soumis par un repos relatif ou une adaptation du programme d’entrainement des sportifs en compétition. Nous pouvons avoir recours à une prise ponctuelle d’AINS, en particulier l’ibuprofène ou à une injection de corticostéroïdes si les douleurs sont incontrôlables et ne permettent pas une rééducation adéquate. Les étirements, qui augmentent la compression du tendon, ou les programmes d’exercices excentriques qui entretiennent le mécanisme de surcharge, ont tendance à aggraver la pathologie dans sa phase aigüe. Late disrepair (stade des remaniements avancés et dégénératifs) Dans la seconde catégorie, après le contrôle de la phase aigüe hyperalgique, il est important de stimuler la régénération tendineuse. C’est à ce moment que les traitements biologiques tels que les ondes de choc et les injections de PRP ou de HA, en fonction de la localisation anatomique des tendinopathies, prennent toute leur importance. Dans cette catégorie, il faut néanmoins se poser la question de la capacité de régénération réelle du tendon lésé et s’il n’est pas plus avantageux d’orienter le traitement vers une amélioration de la résistance à la charge des zones saines adjacentes dans les stades dégénératifs. Les revues systématiques et RCT mettent en évidence l’importance d’une réhabilitation physique après un traitement antalgique ou biologique stimulant. En effet, seule la mise en charge du tendon permet une stimulation et une réorganisation correcte de la matrice et des fibres de collagène. L’alignement optimal des fibres de collagène va permettre d’augmenter la résistance aux contraintes du tendon et ainsi éviter les récidives fréquentes ou l’évolution vers la chronicité. Les traitements excentriques et à charge lourde sont basés sur un programme de réhabilitation progressif de la mise en charge, en fonction de la douleur tolérée par le patient. Dans ce cadre, on pourrait recommander la réalisation d’une séance de contraction isométrique à visée antalgique avant chaque séance afin de permettre une augmentation des charges appliquées et d’améliorer l’efficacité du traitement. Stade réactionnel sur un tendon dégénératif La révision de leur modèle de continuum par Cook et Purdam met en évidence la possibilité de manifestations réactionnelles dans les portions saines d’un tendon dégénératif. Dans un premier temps, la prise en charge, identique à celle d’un épisode réactionnel sur un tendon sain, se fait par repos relatif et utilisation de traitements à visée antalgique. Par la suite, il faut tenir compte de la faible réversibilité des lésions dégénératives sous-jacentes. Les traitements devront, alors être orientés vers une amélioration de la résistance globale à la mise en charge et au bon alignement des fibres du tendon plutôt qu’un traitement biologique stimulant, ciblé sur la zone dégénérative. Ainsi, les programmes de réhabilitation vont permettre de diminuer le nombre d’épisodes réactionnels sur un tendon dégénératif et freiner la progression de la pathologie sur le continuum. Extrait de « Sauvant C, Kaux JF. Prise en charge des tendinopathies en médecine générale. La Revue de la Médecine Générale n° 346, pages 6-14. » [less ▲]

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See detailPrise en charge de l'HTA résistante. Quoi de neuf en 2019?
KRZESINSKI, Jean-Marie ULiege

Conference (2019, May 12)

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See detailConnectomics: Data Analysis
Genon, Sarah ULiege

Conference (2019, May 12)

Connectomics analyses play a major role in our understanding of the human brain organization and function. In this talk, I will present the concepts, methods and applications of a widely used approach to ... [more ▼]

Connectomics analyses play a major role in our understanding of the human brain organization and function. In this talk, I will present the concepts, methods and applications of a widely used approach to examine brain organization: connectivity-based parcellation (CBP). I will then introduce the concepts and methods of connectivity-based psychometric prediction as an approach capitalizing on interindividual variability in brain and behavior to study the relationship between brain organization and behavioral functions. I will here focus on the prediction of psychometric data based on resting-state functional connectivity (rs-fMRI). [less ▲]

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See detailHTA réfractaire et dénervation rénale : regain d'intérêt?
KRZESINSKI, Jean-Marie ULiege; MARTINEZ, Christophe ULiege

Conference (2019, May 11)

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See detailConclusions
Lanneau, Catherine ULiege

Conference (2019, May 11)

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See detailOnline DIVAnd Recent progress \& hurdles
Barth, Alexander ULiege; Beckers, Jean-Marie ULiege; Troupin, Charles ULiege

Conference (2019, May 10)

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See detailAdded value of a regional climate model (MAR) for simulating the current surface mass balance of the Antarctic ice sheet compared to a general circulation model (ACCESS1.3)
Kittel, Christoph ULiege

Conference (2019, May 10)

Due to their ability to produce climate projections, General circulation models (GCM) are often used to provide estimates of the surface mass balance (SMB) of the Antarctic ice sheet that can be used to ... [more ▼]

Due to their ability to produce climate projections, General circulation models (GCM) are often used to provide estimates of the surface mass balance (SMB) of the Antarctic ice sheet that can be used to constrain ice sheet models. However, GCM still benefit from a poor representation of polar climate specificities such as stable boundary layers, polar clouds or interactions between snow-covered surfaces and the atmosphere. In this study, we highlight the importance of downscaling GCM outputs from the Fifth Climate Model Intercomparison Project (CMIP5) with a regional climate model to provide accurate estimates of the Antarctic SMB. For that purpose, the regional climate model MAR is forced by 6-hourly outputs from ACCESS1.3 that is currently considered as one of the best GCM from CMIP5 over the Antarctic ice sheet. Estimates of the SMB computed by MAR and ACCESS1.3 are evaluated against SMB observations. Even if the temporal variability of the SMB is forced by the driving GCM, the comparison shows that MAR improves the spatial variability of the Antarctic SMB, emphasizing the added value of using a polar RCM for downscaling GCM outputs at high latitudes. [less ▲]

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See detailGeneralized Besov spaces : from uniform characterizations to pointwise applications
Loosveldt, Laurent ULiege

Conference (2019, May 10)

We will start the presentation by giving some alternative definitions for the Besov spaces of generalized smoothness. In particular, links between those spaces and Sobolev spaces will be explored. A ... [more ▼]

We will start the presentation by giving some alternative definitions for the Besov spaces of generalized smoothness. In particular, links between those spaces and Sobolev spaces will be explored. A generalized method of interpola- tion will come out from this characterization. Then, we will show how those spaces can help to determine the pointwise regularity of some functions, using wavelet transform and the notion of preva- lence. Once done, links between this pointwise regularity and elliptic partial dif- ferentiable equations will be discussed. This will generalize some results of Calderón and Zygmund. [less ▲]

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See detailDisplaying the Figure of Hercules in Princely Ceremonies during the Late Middle Ages and the Early Modern Period. The Tapestries of the King Charles VIII of France
Laruelle, Anne-Sophie ULiege

Conference (2019, May 10)

Since antiquity, Hercules’ exploits have generated many interpretations. They constituted one of the most popular literary and artistic themes of the Late Middle Ages and the Renaissance. More than any ... [more ▼]

Since antiquity, Hercules’ exploits have generated many interpretations. They constituted one of the most popular literary and artistic themes of the Late Middle Ages and the Renaissance. More than any other ancient figure, Hercules served as a model to sovereigns because he was heralded as the ideal model of Virtue. His Labours were a particularly prolific motif for tapestries. This paper aims to shed new light on the seven-piece tapestry set purchased by the king of France Charles VIII in 1491 (lost today). I will focus on some under-exploited documents (e.g. inventories, contemporary testimonials) and fragments of other series still preserved. The analysis of these exceptional records will allow us to review more broadly the significance of Hercules for Charles VIII. We’ll see that for many special occasions, Hercules embodied the model of the ideal ruler. In addition to being the perfect knight, the king-hero demonstrated a moral force, since he succeeded in overcoming his enemies (associated with monsters and tyrants) by his exceptional qualities. [less ▲]

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See detailCopropriété, leadership et processus décisionnels
Grandjean, Geoffrey ULiege; Ruiz Romera, Anaïs

Conference (2019, May 10)

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See detailBReLLS, Belgian Prospective Registry on consecutive laparoscopic and open liver surgery: Results of the first 18 months enrollment
Troisi, R; Dhondt, M; DETRY, Olivier ULiege et al

Conference (2019, May 10)

Objectives. The BReLLS (Belgian Registry on Laparoscopic Liver Surgery) project is a prospective, non-compulsory, online registry of laparoscopic (LLS) and open (OLS) liver procedures, endorsed by the ... [more ▼]

Objectives. The BReLLS (Belgian Registry on Laparoscopic Liver Surgery) project is a prospective, non-compulsory, online registry of laparoscopic (LLS) and open (OLS) liver procedures, endorsed by the Belgian Section of Hepato-Biliary and Pancreatic Surgery in 2016. The primary aim is to monitor the evolution and spreading of LLS in Belgium. The secondary aim is to evaluate the cost/benefit ratio of LLS in order to allow appropriate reimbursement. Methods. The BReLLS is accessible through a secured SSL server (www.brells.org). Participating centers prospectively record pre-operative, intra-operative and postoperative (90-day morbidity and follow-up) data of all consecutive LLS and OLS. Statistics are generated real-time and are available to each participating center. An audit is planned after the first 2-years of patients enrollment with early oncological follow-up. Results. From February 2017 to October 2018, 12 centers have joint the BReLLS reporting data of 630 procedures (390 LLS and 240 OLS). Indication for LLS were colorectal metastases (46.4%), hepatocellular-carcinoma (17.2%), benign diseases (17%), other metastases (14.1%) and mixed various pathologies (5.3%). LLS encompassed major hepatectomies (16.5%), sectionectomies (14.1%), mono or bi-segmentectomies (20.3%) and sub-segmentectomies (49.1%). LLS were converted to OLS in 4.1% of cases. Overall morbidity was 9.7% for LLS and 29.7% for OLS (p=.0001). Major morbidity (Clavien-Dindo ≥ IIIb) occurred in 1.5% and 5.8% of LLS and OLS (p=.004). 90-days mortality following LLS was nihil vs 1.6% (n=4) for OLS (p=.027). Conclusions. LLS are wide spreading in Belgium. In selected patients, LLS are safe, advantageous and reproducible in major HPB centers. A low morbidity has been prospectively confirmed. Further (ongoing) evaluation will focus on the selection criteria for patients undergoing LLS eventually defining the limits of the minimally invasive approach for malignant diseases. [less ▲]

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See detailLa Conférence de la Paix au prisme de la presse belge (1919)
Lanneau, Catherine ULiege

Conference (2019, May 10)

Il ne peut être question de mener une étude exhaustive sur la couverture médiatique de la Conférence de la paix en Belgique, déjà abordée par certains travaux antérieurs. Notre propos visera donc, en deux ... [more ▼]

Il ne peut être question de mener une étude exhaustive sur la couverture médiatique de la Conférence de la paix en Belgique, déjà abordée par certains travaux antérieurs. Notre propos visera donc, en deux temps, à livrer quelques considérations générales sur la presse écrite face à l’événement puis à décrypter plus en profondeur un moment clé de la Conférence : la première quinzaine de mai 1919, au cours de laquelle les journaux généralistes quotidiens, déçus des clauses enfin dévoilées du futur traité, les commentent et en analysent les conséquences. [less ▲]

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See detailA History of the States’ Europeanness from the EEC/EU Institutions’ Perspective: (Re)considering the Current Relevance of the Institutional Interpretations in Light of the Recent Crises
Niessen, Annie ULiege

Conference (2019, May 10)

According to Article 49(1) of the Treaty on the European Union, any State wishing to apply for EU membership must be “European”, a preliminary eligibility condition which has been enshrined in EU law ... [more ▼]

According to Article 49(1) of the Treaty on the European Union, any State wishing to apply for EU membership must be “European”, a preliminary eligibility condition which has been enshrined in EU law since the Treaty of Rome. Yet, the qualifier “European” has never been explicitly or institutionally defined, despite the fact that it may take on various meanings, going broadly from geographical to cultural ones, including political ones. Failing a clear-cut definition, the EEC/EU institutions have been brought to provide their own interpretations of the requesting States’ European identity – or Europeanness – especially in the course of membership applications, treaty-making processes and enlargement prospects. Focusing on these specific phases, and especially on the membership requests that raised eligibility issues, this paper investigates the various interpretations of the States’ Europeanness that have been provided by the EEC/EU institutions over the last sixty years. The methodological approach relies on a textual and discursive analysis of both recent documents and older records. It then considers, or reconsiders, the current relevance of these interpretations in light of the recent crises that the EU has to handle, such as the United Kingdom’s withdrawal from the EU or the democratic issues in some eastern Member States, and questions the prospective EU (dis)integration based on these institutional interpretations of European identity. [less ▲]

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See detailUn dispositif pédagogique unifiant approche métrologique et expérience sensible dans le cadre de l’atelier d’ingénierie des ambiances urbaines
Nguyen, Ngoc Luan ULiege; Reiter, Sigrid ULiege

Conference (2019, May 09)

L’un des principaux atouts de la formation d’ingénieur architecte de la Faculté des Sciences Appliquées à l’Université de Liège se manifeste dans l’équilibre entre deux compétences complémentaires  ... [more ▼]

L’un des principaux atouts de la formation d’ingénieur architecte de la Faculté des Sciences Appliquées à l’Université de Liège se manifeste dans l’équilibre entre deux compétences complémentaires : l’aptitude à l’innovation et à la créativité, couplée à des ressources techniques nécessaires pour concevoir des bâtiments et des aménagements répondant aux besoins actuels de la société. Intégré dans les objectifs de cette formation, l’atelier d’ingénierie des ambiances urbaines mêle dans ce sens une approche objective, liée à la métrologie et à la maîtrise quantifiée des ambiances, avec une approche subjective, orientée du côté de la perception et de l’expérience sensible. Par le fait que le volet quantitatif permet de justifier les choix de composition architecturale et urbaine basés sur un diagnostic du contexte physique, social et économique, l’atelier allie de ce fait rigueur et créativité. La présentation proposée décrira dans un premier temps le dispositif pédagogique mis en œuvre pour accompagner les étudiants dans la conception et l’évaluation d’ambiances urbaines via la modélisation d’un aménagement durable (mixant conception de l’espace bâti et de l’espace public) qui répond en outre aux critères définis dans le référentiel « Quartiers Durables » conçu par l’Université de Liège et édité par le Service Public de Wallonie. Dans un second temps, la présentation relatera l’expérience accumulée en ce qui concerne l’application du dispositif pédagogique ; cette partie sera illustrée par des projets d’aménagement urbain et périurbain menés par les étudiants au cours des dernières années académiques. [less ▲]

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See detailCitizen Science as Contested Practice in Environmental Governance: Lessons from Post-Fukushima Japan
Van Oudheusden, Michiel ULiege

Conference (2019, May 09)

The rapid emergence of citizen science initiatives in areas such as mobility, conservation, and pollution monitoring raises challenges and opportunities for global environmental governance, inviting ... [more ▼]

The rapid emergence of citizen science initiatives in areas such as mobility, conservation, and pollution monitoring raises challenges and opportunities for global environmental governance, inviting reflection on questions, such as: What is environmental citizen science for? Which data matter? Who benefits from public engagement in science? In this presentation, I draw on fieldwork conducted in Japan after the 2011 Fukushima disaster to provide possible responses to these questions. I highlight how citizen science in radiation monitoring in Japan takes on distinct forms, which defy conventional – often Western – categorizations, such as public participation in science, crowdsourcing, and science democratization. I argue that it is both more accurate and fruitful to conceive of citizen science as a set of varied practices through which participants seek to redefine the terms of scientific and civic membership – often through political contestation and struggle. Drawing attention to these issues underscores the importance of considering how terms and definitions shape the participation of stakeholders (local communities, public authorities, regulators, professional scientists) and allows us to develop new interpretations of citizen engagement with science in culturally and historically sensitive ways. [less ▲]

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See detailCompréhensions contemporaines de la schizophrénie : apports de la phénoménologie et des neurosciences
Englebert, Jérôme ULiege; Constant, Eric

Conference (2019, May 08)

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See detailHow is the science-based stewardship of the Southern Ocean organized and could it be applied to the Arctic Ocean?
Van de Putte, Anton; André, François; Wilmotte, Annick ULiege

Conference (2019, May 08)

During this workshop, the science-based stewardship of the Southern Ocean will be described by Belgian scientists and authorities participating to the Antarctic Treaty System. The possibility to use a ... [more ▼]

During this workshop, the science-based stewardship of the Southern Ocean will be described by Belgian scientists and authorities participating to the Antarctic Treaty System. The possibility to use a similar approach will be discussed with the public, especially the role of scientists in the policy-making, and how it could be improved. The Antarctic Treaty, signed in 1959, designated the Antarctic (area south of 60°S) as an area dedicated to peace and science. It was later complemented by a couple of legally binding international agreements, which form part of the Antarctic Treaty System (ATS) in order to give a better protection to the Antarctic environment. For the sustainable management of the Southern Ocean (south of the Antarctic Convergence), the Convention on the Conservation of Antarctic Marine Living Resources (CCAMLR) was adopted in 1980. CCAMLR makes decisions on matters such as total allowable catches, closing and opening fisheries, and the designation of marine protected areas (MPAs). Its specificity is that the management of fisheries in CCAMLR is guided by an ecosystem-based approach, scientific data and modeling Later, the Protocol on Environmental Protection to the Antarctic Treaty was signed in 1991. It focusses on the continent itself but has also some responsibilities for the protection of marine zones when they are included in Antarctic Protected Areas (ASPA’s and ASMA’s) with a marine component. The connectivity between land and ocean highlight the need of cooperation between the two ATS organizations. Thus, there are meetings between the Scientific Committee of CCAMLR (SC-CCAMLR) and the CEP to discuss how marine spatial protection and management can best be performed across the Antarctic Treaty System, and to seek some harmonization. In the frame of current climate change and related threats, it becomes very urgent to realize a network of representative MPAs. Scientists carry out relevant research that is the basis to provide scientific advice for policy decisions, but they do not always recognize this or find the communication difficult. They may reach to policy-makers through several channels: the Scientific Committee on Antarctic Research (SCAR), their national delegates to CCAMLR and the Committee on Environmental Protection (CEP), but also the Antarctic Environments Portal (www.environments.aq). The interaction between science and policy is crucial but also depends on possibilities for the scientists to gather the needed data and thus, for example, depends on funding for long-term monitoring schemes. [less ▲]

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See detailInsight in René Magritte's reused paintings
Defeyt, Catherine ULiege; Vandepitte, Francisca; Herens, Elodie ULiege et al

Conference (2019, May 08)

The research project, Magritte on practice, consists of the systematic study of the world's largest collection of works painted by the Belgian surrealist (1898-1967), housed at the Magritte Museum in ... [more ▼]

The research project, Magritte on practice, consists of the systematic study of the world's largest collection of works painted by the Belgian surrealist (1898-1967), housed at the Magritte Museum in Brussels, through a large panel of non-invasive scientific imaging and analytical techniques (Raman, FTIR, MA-XRF, hyperspectral, IRR, XRR and digital microscopy) [1]. The technical and material study conducted on a corpus of works covering the entire career of the artist (60 oil paintings realised between 1921 and 1967), appeared highly informative about the making process of Magritte’s pictures but also lead to the discovery of six overpainted compositions, among which the last missing part of La pose enchantée, a 1927 large-scale painting transformed into four separate new pictures that are currently dispersed across the world [2]. The present study proposes an overview of the freshly discovered paintings and explores how the painter reused specific elements from the sacrificed compositions for creating the new ones. References [1] C. Defeyt and F. Vandepitte, (in preparation). René Magritte: The artist’s materials. (Los Angeles, CA: Getty Publications) [2] C. Defeyt, E. Herens, F. Leen, F. Vandepitte and D. Strivay, Heritage Sci., 6 (2018) [less ▲]

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See detailL’individu en contexte: comprendre le phénomène de la radicalisation
Garcet, Serge ULiege

Conference (2019, May 07)

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See detailEnvironmental drivers of sea stars feeding ecology in the Southern Ocean
Le Bourg, Baptiste ULiege; Blanchard, Alice; Danis, Bruno et al

Conference (2019, May 06)

The Antarctic continent and the surrounding Southern Ocean undergo strong and contrasted impacts of climate change. In the Western Antarctic Peninsula, sea ice cover and ice season duration are decreasing ... [more ▼]

The Antarctic continent and the surrounding Southern Ocean undergo strong and contrasted impacts of climate change. In the Western Antarctic Peninsula, sea ice cover and ice season duration are decreasing, presumably in relation with increased air and water temperature and northwesterly winds originating from the also warming subtropical Pacific. In contrast, despite increased air and deep water temperatures, sea ice cover and ice season duration are increasing in other Antarctic regions. This is possibly linked with ocean stratification due to freshwater inputs from the melting continental ice. These changes are likely to impact marine communities and food webs of the Southern Ocean. Sea stars (Echinoderms: Asteroidea) are an important group of the Southern Ocean benthos. Compared to other organisms, they seem to have relatively high physiological tolerance to warming. However, they could be indirectly affected by climate change, notably through quantitative and qualitative modifications of food availability. In this context, the aim of this study was to infer the trophic diversity of sea stars of the Southern Ocean to assess their potential trophic plasticity regarding food web changes. Thanks to collaborative networking and valorization of museum samples, Sea stars samples taken in summer in various regions around the Antarctic continent with different types of environment (Antarctic or Subantarctic, deep-sea or coastal, presence of sea ice or not) were obtained. Stable isotopes ratios of C (denoted δ13C) and N (denoted δ15N) were then analysed in the tegument of sea stars in order to investigate their trophic ecology. Isotopic niches metrics were also computed to assess differences of trophic diversity between regions. Variability in stable isotope ratios and isotopic niche metrics revealed strong differences in sea star feeding ecology between and within locations, possibly in relation with differences in environmental conditions, notably sea ice coverage and dynamics. For example, on the continental shelf of Antarctic South Shetland Islands, small isotopic niches could indicate that sea stars exploit a food web based on a common basal food source and exhibit a "trophic continuum". In this context, absence of sea ice before and during the sampling period could have limited the number of available food sources. By contrast, on the continental shelf of the Antarctic Marguerite Bay or in the Subantarctic South Georgia Island, sea stars had large isotopic niches that suggest that they could exploit one or several food webs based on more than one food source, and exhibited strong trophic segregation. In Marguerite Bay, this could be linked with progressive sea ice melting, which allows export of both sea ice materials and blooming phytoplankton to the benthic compartment. In South Georgia, on the other hand, oligotrophic conditions and thus reduced availability of phytoplankton are more likely to explain this pattern. Ultimately, this project helps us understanding which ecological processes determine how an ecologically important animal group copes with environmental modifications linked to climate change. This research was funded by the Belgian Federal Science Policy Office (BELSPO) in the framework of the vERSO  and RECTO project (rectoversoprojects.be). [less ▲]

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See detailAnalyse et modélisation de la mortalité de larves d'Hylotrupes bajulus (L.) lors de traitements par anoxie en vue d'une application à la conservation d'objets d'intérêt patrimonial
de Streel, Géraud; Henin, Jean-Marc; Bogaert, Patrick et al

Conference (2019, May 03)

Nous avons conçu des expérimentations visant à établir un modèle quantifiant les effets de certaines variables clef sur la mortalité. Cette étude a pour but d’explorer les potentialités d’avoir recours à ... [more ▼]

Nous avons conçu des expérimentations visant à établir un modèle quantifiant les effets de certaines variables clef sur la mortalité. Cette étude a pour but d’explorer les potentialités d’avoir recours à une approche de modalisation pour faciliter la détermination des paramètres de traitement à appliquer lors d’un traitement par anoxie pour atteindre un objectif donné de mortalité des larves. Les expériences ont été réalisées sur Hylotrupes bajulus (L.) (Capricorne des maisons), une espèce largement répandue dans les collections et connue pour sa grande résistance au traitement par anoxie. Les variables considérées comprennent la masse initiale des larves, la température de traitement (21, 30 ou 40°C), la durée de traitement et l’environnement dans lequel la larve est maintenue lors du traitement (en boite de Pétri ou implantée en planchette de bois). Nous n’avons pas mis en évidence de lien entre l’environnement et la mortalité. En revanche, la durée de traitement ainsi que la température sont toutes deux positivement corrélées à la mortalité. La masse initiale des larves est également un facteur important puisque les larves dont la masse initiale était plus importante ont montré une résistance accrue au traitement. Sur base de ces résultats, un modèle intégrant la masse initiale, la température de traitement, la durée du traitement ainsi que l’interaction entre ces deux dernières variables a été établi. Ce modèle relativement simple semble être un outil intéressant pour résoudre la difficulté que consiste le fait de déterminer les paramètres de traitement nécessaires pour atteindre un certain niveau de mortalité. [less ▲]

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See detailEnhanced Laplace transform and holomorphic Paley-Wiener-type theorems
Dubussy, Christophe ULiege

Conference (2019, May 03)

Starting from a remark about the computation of Kashiwara-Schapira’s enhanced Laplace transform by using the Dolbeault complex of enhanced distributions, we will explain how to obtain explicit holomorphic ... [more ▼]

Starting from a remark about the computation of Kashiwara-Schapira’s enhanced Laplace transform by using the Dolbeault complex of enhanced distributions, we will explain how to obtain explicit holomorphic PaleyWiener-type theorems. As an example, we will get back some classical theorems due to Polya and Méril. In particular, we will show how contour integrations naturally appear in this framework. [less ▲]

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See detailNationalisme étatique et nationalisme ethnique: quelle critique pour quelle vision de l'Union européenne? Le cas du Rassemblement National et du Freiheitliche Partei Österreichs
Debras, François ULiege

Conference (2019, May 03)

Après une période de dédiabolisation et grâce à une base électorale croissante, de plus en plus de partis d’extrême droite européens se revendiquent aujourd’hui comme "démocratiques". En écartant de la ... [more ▼]

Après une période de dédiabolisation et grâce à une base électorale croissante, de plus en plus de partis d’extrême droite européens se revendiquent aujourd’hui comme "démocratiques". En écartant de la scène politique et médiatique leurs membres les plus violents, en respectant les procédures électorales et en proposant des programmes alternatifs vis-à-vis des partis traditionnels, les organisations d’extrême droite s’intégreraient durablement au sein de nos systèmes politiques jusqu’à se présenter, dans certains pays, comme les véritables représentants du peuple, les défenseurs des libertés individuelles et les promoteurs d’une véritable démocratie loin des bureaucrates et technocrates de Bruxelles.Cette critique des institutions européennes et de leur mode de fonctionnement repose sur une idéologie nationaliste. Cependant, d'un point de vue empirique, les positions du RN et du FPÖ vis-à-vis de l'UE ne sont pas similaires. Quelles différences observons nous (critique existentielle et critique fonctionnelle)? Quelles idéologies sous-tendent ces critiques (nationalisme étatique et nationalisme ethnique)? Comment ces deux partis se positionnent-ils par rapport aux enjeux de l'UE (sortie et changement)? [less ▲]

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See detailRamifications mayençaises de la geste du roi : Renaud dans l’épisode d’Aspremont de Gerard du Frattre
Lambert, Adélaïde ULiege

Conference (2019, May 03)

Cet exposé s'est focalisé sur le déploiement de la Geste de Doolin de Maïence au sein de deux proses traditionnellement associées au cycle du roi : Fierabras et Aspremont compilées dans Gerard du Frattre ... [more ▼]

Cet exposé s'est focalisé sur le déploiement de la Geste de Doolin de Maïence au sein de deux proses traditionnellement associées au cycle du roi : Fierabras et Aspremont compilées dans Gerard du Frattre. L’arbre généalogique des fils de Doon du premier chapitre de Gerard et la promesse d’une suite sur Renaud apparaissent comme des bornes fixes depuis le Myreur des Histors de Jean d'Outremeuse jusqu'à l'imprimé Gerard d’Euphrate de 1549, entre lesquelles les prosateurs ont pu réinvestir l’histoire de Gérard de manière extrêmement libre, selon leur projet littéraire. Le rassemblement de Fierabras et d’Aspremont s'observe en outre dès le XVe s., dans l'anthologie chevaleresque de Marguerite d'Anjou (ms. LONDON, British Library, Royal 15.E.VI) et dans les Croniques et Conquestes de David Aubert. Mais l'ordre des légendes est inversé dans Gerard et elles sont soudées l'une à l'autre, notamment par le biais du personnage de Renaud ajouté aux narrations par le compilateur. Le prosateur emploie deux techniques pour développer les actions de ce jeune héros mayençais : tantôt, il amplifie un motif présent dans son modèle ; tantôt, il redistribue les rôles qu'occupent les personnages (par exemple, celui du meurtrier d’Angoulant). Du côté des ennemis païens également, la continuité narrative de Fierabras et Aspremont repose sur des rapports généalogiques renouvelés : l'enchaînement des légendes est assuré par la vengeance, basée sur les liens du sang. La cyclisation et la compilation sont ainsi interdépendantes, et figurent deux aspects d'un même procédé. [less ▲]

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