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See detailComment amorcer la construction identitaire d'un praticien réflexif par la formation initiale ?
Beckers, Jacqueline ULiege

in Recherche et Formation (2004), 46

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See detailLiquid-liquid phase separation in gravity settler with inclined plates
Schlieper, L; Chatterjee, M; Henschke, Martin et al

in AIChE Journal (2004), 50(4), 802-811

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See detailLe cas clinique du mois. Purpura révélateur d'un rhumatisme articulaire aigu.
Fumal, I.; Henry, Frédérique ULiege; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2004), 59(11), 630-2

We report the case of an adult who presented cutaneous manifestations of rheumatic fever. The lesions are rarely diagnosed. However, they represent a clue inciting a specific diagnostic search for ... [more ▼]

We report the case of an adult who presented cutaneous manifestations of rheumatic fever. The lesions are rarely diagnosed. However, they represent a clue inciting a specific diagnostic search for identifying the disease. [less ▲]

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See detailINFECTIONS ET PROPHYLAXIES ANTIINFECTIEUSES DANS LA DRÉPANOCYTOSE
Lepage, P; DRESSE, Marie-Françoise ULiege; FORGET, Patricia ULiege et al

in Revue Médicale de Liège (2004), 59(3), 145-148

Bacterial infections remain a major cause of morbidity and mortality among young children with sickle cell susceptibility to infections is mainly observed in homozygous sickle cell disease. The incidence ... [more ▼]

Bacterial infections remain a major cause of morbidity and mortality among young children with sickle cell susceptibility to infections is mainly observed in homozygous sickle cell disease. The incidence of bacteremias in children under 3 years of age is ~8 events/100 patient-years among homozygous subjects and ~5 events/100 patient-years among those with SC hemoglobinopathy. Pneumococci and Salmonellae are the most frequently isolated bacteria. Severe clinical manifestations include septicemia, meningitis, osteomyelitis and pneumonia. M. Pneumoniae and C. Pneumoniae infections may be severe and may induce acute chest syndrome. The high incidence and severity of bacterial infections in these children justify prevention efforts by antibiotic prophylaxis and vaccination. The efficacy of oral penicillin prophylaxis against pneumococcal infections has been well demonstrated and is now recommended from 3 months of age. The antipneumococcal conjugate vaccine has been shown to be safe and immunogenic in young infants. [less ▲]

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See detailAgeing across the life span: time to think again.
Pierard, Gérald ULiege

in Journal of Cosmetic Dermatology (2004), 3(1), 50-3

Living organisms are subject to ageing. This natural process has gained greater importance in socially and medically affluent societies. For many, ageing connotes unattractive changes in the appearance of ... [more ▼]

Living organisms are subject to ageing. This natural process has gained greater importance in socially and medically affluent societies. For many, ageing connotes unattractive changes in the appearance of the skin. The gross morphological changes of ageing skin are mirrored by a range of more profound age-associated physiological declines. Thus, skin ageing can be put into other perspectives which lie at the interfaces of molecular biology, cellular biology, oncology and cosmetic dermatology. Genetically programmed replicative senescence and stress-induced premature senescence (SIPS) are two processes that are fundamental to skin ageing. Some iteroparous species can be used as animal models for human ageing. Undoubtedly, scientific understanding of skin ageing is firmly rooted in the distinction between intrinsic and extrinsic types of ageing. However, seven major types of skin ageing can be distinguished: genetic, chronological, solar, behavioural, endocrinological, catabolic and gravitational types. Preventative measures can target each of these. [less ▲]

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See detailSynopsis des mécanismes pathogéniques des toxidermies graves.
Paquet, Philippe ULiege; Pierard, Gérald ULiege

in Dermatologie Actualité (2004), 85

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See detailLe WOCCQ, un outil de diagnostic des risques psychosociaux liés au travail. Création de normes et développement d'une base de données
Hansez, Isabelle ULiege; Mahy, Aude; Grisard, Anne et al

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2004), 41(2), 79-84

Le taux d’emploi des travailleurs âgés de plus de 55 ans en Belgique est un des plus faibles d’Europe. Notre pays est loin d’atteindre les objectifs de taux d’emploi inscrits dans la Stratégie Européenne ... [more ▼]

Le taux d’emploi des travailleurs âgés de plus de 55 ans en Belgique est un des plus faibles d’Europe. Notre pays est loin d’atteindre les objectifs de taux d’emploi inscrits dans la Stratégie Européenne de l’Emploi. Ce constat doit donc inciter les autorités publiques, les entreprises et les travailleurs à réagir. Si les premières ont commencé à mettre en place des mesures structurelles pour remédier au problème, les entreprises et les travailleurs ne sont pas toujours conscients de la marge de manœuvre dont ils disposent pour relever le défi. Les stéréotypes des unes et une certaine culture du « droit à la retraite » des autres sont des obstacles de première ligne. C’est pourquoi il est primordial d’engager des sensibilisations à leur égard. Cet article présente les résultats d’une recherche menée auprès de travailleurs belges pour évaluer les motifs de départ, et la place des conditions de travail et du stress dans l’explication des retraits prématurés. Les résultats fournissent un matériel solide pour orienter non seulement la sensibilisation, mais aussi les actions à mettre en place au sein des entreprises pour encourager le maintien dans l’emploi des plus âgés. On notera par exemple que la prévention doit débuter avec les travailleurs dès l’âge de 46 ans, que la lutte contre le stress lié aux conditions de travail est nécessaire mais non suffisante pour prévenir les retraits prématurés, et qu’il faut surtout se concentrer sur une meilleure gestion des changements organisationnels et la valorisation du personnel pour endiguer les départs anticipés. [less ▲]

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See detailVaricella-Zoster virus proteins encoded by open reading frames 14 and 67 are both dispensable for the establishment of latency in a rat model.
Grinfeld, Esther; Sadzot-Delvaux, Catherine ULiege; Kennedy, Peter G E

in Virology (2004), 323(1), 85-90

A rat model of Varicella-Zoster virus (VZV) provides a system in which to investigate the molecular determinants of viral latency in dorsal root ganglia (DRG). In this study, we determined whether the VZV ... [more ▼]

A rat model of Varicella-Zoster virus (VZV) provides a system in which to investigate the molecular determinants of viral latency in dorsal root ganglia (DRG). In this study, we determined whether the VZV glycoproteins gC and gI, corresponding to VZV open reading frames (ORFs) 14 and 67, respectively, were required for the establishment of latency in this model. A VZV gI deletion mutant (DeltagI) derived from a recombinant Oka (rOka) cosmid and a gC null mutant obtained from a clinical isolate were inoculated into the footpads of 6-week-old rats, and the presence of viral DNA and eight different VZV RNA transcripts corresponding to the three classes of genes was investigated by in situ RT-PCR amplification and in situ hybridization (ISH) in the DRG at 1 week, 1 month, and 18-24 months after infection. VZV DNA and restricted RNA expression was established with both deletion mutants as well as the parental rOka virus. Both VZV DNA and RNA were detected in neurons and non-neuronal cells. The pattern of viral RNA expression detected with both gC and gI mutants was restricted with transcripts for VZV genes 62 and 63 most frequently expressed 18-24 months after infection. Transcripts for VZV genes 18, 28, and 29 were also detected at these time points but at a slightly lower frequency. Transcripts for the late gene 40 were never detected. We conclude that VZV ORFs 14 and 67 are dispensable for the establishment of a latent infection in this model. [less ▲]

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See detailDR-CALUX((R)) screening of food samples: evaluation of the quantitative approach to measure dioxin, furans and dioxin-like PCBs
Scippo, Marie-Louise ULiege; Eppe, Gauthier ULiege; De Pauw, Edwin ULiege et al

in Talanta (2004), 63(5), 1193-1202

European legislation laid down maximum tolerable levels of dioxin in feed and food as well as analytical method requirements. In order to face with large monitoring programs, it was foreseen in the EU ... [more ▼]

European legislation laid down maximum tolerable levels of dioxin in feed and food as well as analytical method requirements. In order to face with large monitoring programs, it was foreseen in the EU strategy to integrate screening methods, using either a qualitative (screening) approach, or a quantitative approach. In this study, dioxin results obtained using the Dioxin Responsive Chemical-Activated LUciferase gene eXpression (DR-CALUX(R)) cell-based assay (quantitative approach), were compared with gas chromatography-high resolution mass spectrometry (GC-HRMS) analyses data. Instead of using World Health Organization-toxic equivalent factor (WHO-TEF), the comparison was based on the assessment of relative effective potencies (REPs) for each congener of the 17 toxic 2,3,7,8-polychlorodibenzo-p-dioxins/furans (PCDD/Fs) and 12 dioxin-like polychlorobiphenyls (DL-PCBs). According to published data, DR-CALUX(R)-REP evaluated here appear similar to WHO-TEF for PCDD/Fs while lower values were observed for DL-PCBs. We analyzed two "home made" contaminated fat samples, displaying both the same WHO-toxic equivalent quantities (WHO-TEQ) concentration (12 pg WHO-TEQ g(-1)). They were spiked with either a low or a high amount of DL-PCBs. In both cases, the DR-CALUX(R) measured concentration (picogram 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) eq. g(-1)) corresponded to the PCDD/Fs WHO-TEQ concentration only. A good agreement was nevertheless found between the DR-CALUX(R) measurements and the recalculated DR-CALUX(R)-TEQ contents (using DR-CALUX(R)-REP instead of WHO-TEF), demonstrating that the observed response was due, in both cases, to the addition of the responses of the standards added to the fat. By contrast, in real contaminated samples (feed or cod liver samples), DR-CALUX(R) measured concentrations were similar to WHO-TEQ GC-HRMS measured concentrations. But, depending on the PCDD/Fs and DL-PCBs congener content, the DR-CALUX(R) measured concentrations were either lower or higher than calculated DR-CALUX(R)-TEQ contents, demonstrating that possible co-extracted contaminants contributed to the CALUX response. Owing to these divergences, the quantitative determination of dioxin-like content in food and feed using CALUX as screening method is questionable, except for samples displaying constant congener patterns, in which cases, correction factors could be applied. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailOrdre public, adoption internationale et Convention européenne des droits de l’homme
Collienne, Fleur ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2004)

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See detailMineral mapping in salt lakes from Sud Lipez (Bolivia) using Aster images
Caceres, Fernando; Ali-Ammar, Hamid; Pirard, Eric ULiege

in Geological Remote Sensing Group Newsletter (2004), (38), 15-19

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See detailRegulation of opposition and coeducation within a martial arts school
Lenzen, Benoît; Dejardin, Robert; Cloes, Marc ULiege

in STAPS : Revue Internationale des Sciences du Sport et de l'Education Physique (2004), 66

In Japanese martial arts, the regulation of opposition does not lie on impersonal rules as in combat sports. Assuming that a control regulation from the teachers and an autonomous regulation from the ... [more ▼]

In Japanese martial arts, the regulation of opposition does not lie on impersonal rules as in combat sports. Assuming that a control regulation from the teachers and an autonomous regulation from the learners jointly contribute to the solving of this concrete problem, this study tried (1) to identify and describe strategies used by the members (male and female) of a traditional private school to regulate the opposition on the tatami, and (2) to understand the rationality underlying these strategies. A qualitative analysis based on the use of several sources of data (interviews, observations, various documents) and of an original model revealed that what gender considered, the weakest practitioners were driven by a security stake. This common stake was coupled for men with a symbolic stake of preservation of their male sexual status, driving them to adopt tacit avoiding strategies. On the contrary, women negotiated openly with their rough partners, putting their feminine condition forward. The pedagogical intervention should take the existence of such a sexed autonomous regulation into account. [less ▲]

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See detailReduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling
Conzelmann, Holger; Saez-Rodriguez, Julio; Sauter, Thomas et al

in IEE Proceedings - Systems Biology (2004), 1(1), 159-169

Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain ... [more ▼]

Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain qualitative and, most importantly, quantitative knowledge about such complex systems. However, a detailed mathematical description of these systems leads to nearly unmanageably large models, especially when combining models of different signalling pathways to study cross-talk phenomena. Therefore, simplification of models becomes very important. Different methods are available for model reduction of biological models. Importantly, most of the common model reduction methods cannot be applied to cellular signal transduction pathways. Using as an example the epidermal growth factor (EGF) signalling pathway, we discuss how quantitative methods like system analysis and simulation studies can help to suitably reduce models and additionally give new insights into the signal transmission and processing of the cell [less ▲]

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See detailA benchmark for methods in reverse engineering and model discrimination: Problem formulation and solutions
Kremling, Andreas; Fischer, Sophia; Gadkar, Kapil et al

in Genome Research (2004), 14(9), 1773-1785

A benchmark problem is described for the reconstruction and analysis of biochemical networks given sampled experimental data. The growth of the organisms is described in a bioreactor in which one ... [more ▼]

A benchmark problem is described for the reconstruction and analysis of biochemical networks given sampled experimental data. The growth of the organisms is described in a bioreactor in which one substrate is fed into the reactor with a given feed rate and feed concentration. Measurements for some intracellular components are provided representing a small biochemical network. Problems of reverse engineering, parameter estimation, and identifiability are addressed. The contribution mainly focuses oil the problem of model discrimination. If two or more model variants describe the available experimental data, a new experiment must be designed to discriminate between the hypothetical models. For the problem presented, the feed rate and feed concentration of a bioreactor system are available as control inputs. To verify calculated input profiles an interactive Web site (http://www.sysbio.de/projects/benchmark/) is provided. Several solutions based oil linear and nonlinear models are discussed. [less ▲]

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See detailAlternative Didaktik im Fremdsprachenunterricht im Zeitraum 1945-1980. Ein Beitrag zur Geschichte der Didaktik
Vanhaegendoren, Koen ULiege

in Zeitschrift der Germanisten Rumäniens (2004), 25-26

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See detailDrei Thesen zur Literaturdidaktik im Fremdsprachenunterricht
Vanhaegendoren, Koen ULiege

in Epos. Revista de filología (2004), 20-21

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See detailKritische Notizen zur Deutung des Realismus in Ingeborg Bachmanns Zikaden
Vanhaegendoren, Koen ULiege

in Studi Germanici (2004), 42

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See detailFully automated method for the liquid chromatographic-tandem mass spectrometric determination of cyproterone acetate in human plasma using restricted access material for on-line sample clean-up.
Christians, Benoit; Fillet, Marianne ULiege; Chiap, Patrice ULiege et al

in Journal of Chromatography. A (2004), 1056(1-2), 105-10

A new automated method for the quantitative analysis of cyproterone acetate (CPA) in human plasma has been developed using on-line solid phase extraction (SPE) prior to the LC-MS/MS determination. The ... [more ▼]

A new automated method for the quantitative analysis of cyproterone acetate (CPA) in human plasma has been developed using on-line solid phase extraction (SPE) prior to the LC-MS/MS determination. The method was based on the use of a pre-column packed with internal-surface reversed-phase material (LiChrospher RP-4 ADS, 25 mm x 2 mm) for sample clean-up coupled to LC separation on an octadecyl silica stationary phase by means of a column switching system. A 30 microl plasma sample volume was injected directly onto the pre-column using a mixture of water, acetonitrile and formic acid (90:10:0.1 (v/v/v)) adjusted to pH 4.0 with diluted ammonia as washing liquid. The analyte was then eluted in the back-flush mode with the LC mobile phase consisting of water, methanol and formic acid (10:90:0.1 (v/v/v)). The dispensing flow rates of the washing liquid and the LC mobile phase were 300 microl min(-1). Medroxyprogesterone acetate (MPA) was used as internal standard. The MS ionization of the analytes was achieved using electrospray (ESI) in the positive ion mode. The pseudomolecular ionic species of CPA and MPA (417.4 and 387.5) were selected to generate daughter ions at 357.4 and 327.5, respectively. Finally, the developed method was validated according to a new approach using accuracy profiles as a decision tool. Very good results with respect to accuracy, detectability, repeatability, intermediate precision and selectivity were obtained. The LOQ of cyproterone acetate was 300 pg ml(-1). [less ▲]

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See detailGenetic structuralism, psychological sociology and pragmatic social actor theory, Proposals for a convergence of French sociologies
Frère, Bruno ULiege

in Theory, Culture & Society (2004), 21(3), 85-99

This paper would like to show that Wittgenstein and Freud have exerted a considerable - though narrow - influence on Bourdieu's sociology. But they also pervade the theoretical development of two other ... [more ▼]

This paper would like to show that Wittgenstein and Freud have exerted a considerable - though narrow - influence on Bourdieu's sociology. But they also pervade the theoretical development of two other currents, which have emerged in French Sociology in the last few years, and were developed by L. Boltanski and L. Thevenot, on the one hand, and B. Lahire, on the other. Although they do not make it explicit, the advocates of these two currents have nevertheless been influenced by Wittgenstein and Freud. Thus Boltanski has drawn on Wittgenstein to develop a sociology which gives primacy to the social actor's interpretation of his or her situation through lay theorising. Lahire's work clearly pays a debt to Freud with his psychological sociology. It would therefore be interesting, in the first instance, to tease out how Wittgenstein and Freud, respectively, have influenced these two systems to demonstrate that they can indeed be used to generate new sociological currents, other than Bourdieu's own. This would then allow us to explore how they could be used to fill any gaps in Bourdieu's work, thus giving the latter renewed relevance and staunching its stagnating tendencies. But, ultimately, this analysis aims to show how Wittgenstein’s and Freud's theoretical influences can lead the way towards a theoretical synthesis between Bourdieu's critical sociology, Boltanski's social actor theory and Lahire's psychological sociology. Currently, these three currents operate independently of each other, without any kind of dialogue. And yet, far from being incompatible, these sociologies offer opportunities for exploring how they might complement each other and for mutual enrichment. [less ▲]

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See detailNon-uniform adaptive vertical grids in one-dimensional numerical ocean models
Burchard, Hans; Beckers, Jean-Marie ULiege

in Ocean Modelling (2004), 6(1), 51-81

It is demonstrated in this paper how the concept of general vertical coordinates can be exploited for constructing adaptive grids in primitive equation ocean models. The term adaptive is used here in the ... [more ▼]

It is demonstrated in this paper how the concept of general vertical coordinates can be exploited for constructing adaptive grids in primitive equation ocean models. The term adaptive is used here in the sense of coordinate iso-surfaces which follow certain internal structures of the flow in such a way that higher vertical resolution is obtained in locations where vertical gradients are large. The internal structures considered here are shear and stratification. In this paper, one-dimensional models are applied in order to demonstrate the ability of such grid adaptation methods to follow internal structures even in flow situations dominated by vertical mixing processes. Here, a variational approach is considered for the generation of grids which results in a diffusion equation for the vertical coordinate. The method is tested for five different idealised and realistic scenarios with the result that the discretisation error can be significantly reduced in comparison to equidistant Cartesian grids. Some recommendations for extending these methods for three-dimensional models are given at the end of this paper. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailTélédétection et télégestion des informations géologiques : de nouvelles technologies au service du développement.
Pirard, Eric ULiege; Caceres, Fernando

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (2004), 50(3), 321-348

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See detailXPS data analysis via Wavelets and Fourier Transform.
Charles, Catherine ULiege; Rasson, Jean-Paul; Leclerc, Gervais

in Surface and Interface Analysis [=SIA] (2004), 36

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See detailNouvelles approches du diagnostic et de la pathogénie du diabète de type 1
Geenen, Vincent ULiege

in Louvain Medical (2004), 123

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See detailL’application de la loi dans le temps en matière de roulage
Jacobs, Ann ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2004)

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See detailATP Augments von Willebrand Factor-dependent Shear-induced Platelet Aggregation through Ca2+-Calmodulin and Myosin Light Chain Kinase Activation
Oury, Cécile ULiege; Sticker, Elsie; Cornelissen, Heidi et al

in Journal of Biological Chemistry (2004)

Shear stress triggers von Willebrand factor (VWF) binding to platelet glycoprotein Ibalpha and subsequent integrin alpha(IIb)beta(3)-dependent platelet aggregation. Concomitantly, nucleotides are released ... [more ▼]

Shear stress triggers von Willebrand factor (VWF) binding to platelet glycoprotein Ibalpha and subsequent integrin alpha(IIb)beta(3)-dependent platelet aggregation. Concomitantly, nucleotides are released from plateletdense granules, and ADP is known to contribute to shear-induced platelet aggregation (SIPA). This study shows that ATP also contributes to SIPA. The ATP-gated P2X(1) ion channel induces MLC-mediated cytoskeletal rearrangements that increases platelet degranulation during VWF-triggered platelet activation. [less ▲]

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See detailTumour necrosis factor- receptor 1 and 2 polymorhpisms in inflammatory bowel disease and their association with response to infliximab
Pierik, M.; Vermeire, S.; Van Steen, Kristel ULiege et al

in Alimentary Pharmacology & Therapeutics (2004), 20

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See detailHa una pistola per eliminare mio marito?
D'Amore, Salvatore ULiege

in Ecologia della Mente (2004), 26(1), 71-102

Recent theoretical and clinical contributions of elderly couple with alcoholic partner underlies the usefulness of pragmatic/interactive and semantic/symbolic approach of symptomatic situation ... [more ▼]

Recent theoretical and clinical contributions of elderly couple with alcoholic partner underlies the usefulness of pragmatic/interactive and semantic/symbolic approach of symptomatic situation. Particularly, alcohol-dependance is understood as related to developmental tasks, resources and bonds of life-cycle of elderly age. A psychotherapeutic process of elderly couple is narrated. This work is caractherized by the following phases: alcoholistic symptom control, individual and family story narration and renegociation and reshaping of couple spaces/times. Symptom gradual dissolution has permitted the relaunching of individual, couple and familial planning as a fundamental dimension for improving general quality life of elderly couple. [less ▲]

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See detailIntroducing the multivariate dale model in population-based genetic association studies
Van Steen, Kristel ULiege; Tahri, N.; Molenberghs, G.

in Biometrical Journal = Biometrische Zeitschrift (2004), 46(2), 187-202

Until recently, the most common parametric approaches to study the combined effects of several genetic polymorphisms located within a gene or in a small genomic region are, at the genotype level, logistic ... [more ▼]

Until recently, the most common parametric approaches to study the combined effects of several genetic polymorphisms located within a gene or in a small genomic region are, at the genotype level, logistic regressions and at the haplotype level, haplotype analyses. An alternative modeling approach, based on the case/control principle, is to regard exposures (e.g., genetic data such as derived from Single Nucleotide Polymorphisms - SNPs) as random and disease status as fixed and to use a marginal multivariate model that accounts for inter-relationships between exposures. One such model is the multivariate Dale model. This model is based on multiple logistic regressions. That is why the model, applied in a case/control setting, leads to straightforward interpretations that are similar to those drawn in a classical logistic modeling framework. [less ▲]

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See detailLes déficits phonologiques des enfants francophones ayant des troubles spécifiques de développement du langage
Parisse, Christophe; Maillart, Christelle ULiege

in Glossa (2004), 89

This study investigated the phonological expressive disorders of Frenchspeaking children with SLI. The main goal of this paper was to confirm whether children with SLI have limitations in phonological ... [more ▼]

This study investigated the phonological expressive disorders of Frenchspeaking children with SLI. The main goal of this paper was to confirm whether children with SLI have limitations in phonological ability even when they are compared with normally-developing children matched by MLU and phonemic inventory size. This was demonstrated by Bortoloni and Leonard (2000), Orsolini et coll. (2001), and Aguilar-Mediavilla et coll. (2002), which obtained the most detailed results in this direction, but it was never tested in French language. The second goal of the paper is to find out whether the characteristics of the French language are reflected in the nature of the children’s phonological disorder. In order to test this, the spontaneous language of 16 children with SLI and of 16 control children matched on MLU and phonemic inventory size (NLD group) was analysed using different measures bearing on utterances, words, syllables, or phonemes. In both SLI and NLD groups, the children were distributed in two different subgroups, on the basis of their MLU and phonemic inventory size. The results supported a specific limitation in the phonological abilities of French children with SLI, as was already demonstrated for English, Hebrew, Italian, and Spanish-Catalan. However, two unexpected results were also obtained. Firstly, a significant difference between children with SLI and control children could only be found for older children (MLU above 3), not for younger children with MLU below 3. This was true for all measures. This finding stresses out the importance of having a development perspective and has to be confirmed with longitudinal design. Secondly, deficits were much more important at the phoneme level than at the syllable level. This can be explained by the fact that the French language has a very homogenous pronunciation of syllables, which makes them easier to segment. [less ▲]

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See detailHREELS Signal Processing Via Wavelets.
Charles, Catherine ULiege; Leclerc, Gervais; Rasson, Jean-Paul

in Surface and Interface Analysis [=SIA] (2004), 36

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See detailValorisation industrielle de la pomme de terre.
Delaplace, Pierre ULiege; Fauconnier, Marie-Laure ULiege

in Troupeaux et Cultures des Tropiques (2004)

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See detailL’ironie dans Ounamon : les emplois de mk et de ptr
Winand, Jean ULiege

in Göttinger Miszellen (2004), (200), 105-110

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See detailIdentification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites.
Lecut, Christelle ULiege; Arocas, Veronique; Ulrichts, Hans et al

in Journal of Biological Chemistry (2004), 279(50), 52293-9

Glycoprotein VI (GPVI) has a crucial role in platelet responses to collagen. Still, little is known about its interaction with its ligands. In binding assays using soluble or cell-expressed human GPVI, we ... [more ▼]

Glycoprotein VI (GPVI) has a crucial role in platelet responses to collagen. Still, little is known about its interaction with its ligands. In binding assays using soluble or cell-expressed human GPVI, we observed that (i) collagen, and the GPVI-specific ligands collagen-related peptides (CRP) and convulxin, competed with one another for the binding to GPVI and (ii) monoclonal antibodies directed against the extracellular part of the human receptor displayed selective inhibitory properties on GPVI interaction with its ligands. Monoclonal antibody 9E18 strongly reduced the binding of GPVI to collagen/CRP, 3F8 inhibited its interaction with convulxin, whereas 9O12 prevented all three interactions. These observations suggest that ligand-binding sites are distinct, exhibiting specific features but at the same time also sharing some common residues participating in the recognition of these ligands. The epitope of 9O12 was mapped by phage display, along with molecular modeling of human GPVI, which allowed the identification of residues within GPVI potentially involved in ligand recognition. Site-directed mutagenesis revealed that valine 34 and leucine 36 are critical for GPVI interaction with collagen and CRP. The loop might thus be part of a collagen/CRP-binding site. [less ▲]

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See detailPrincipal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formation.
Lecut, Christelle ULiege; Schoolmeester, Anne; Kuijpers, Marijke J E et al

in Arteriosclerosis, Thrombosis, and Vascular Biology (2004), 24(9), 1727-33

OBJECTIVE: High-shear perfusion of blood over collagen results in rapid platelet adhesion, aggregation, and procoagulant activity. We studied regulation of alpha2beta1 and alphaIIbbeta3 integrin ... [more ▼]

OBJECTIVE: High-shear perfusion of blood over collagen results in rapid platelet adhesion, aggregation, and procoagulant activity. We studied regulation of alpha2beta1 and alphaIIbbeta3 integrin activation during thrombus formation on collagen. METHODS AND RESULTS: Blockade of glycoprotein (GP) VI by 9O12 antibody or of P2Y purinergic receptors permitted platelet adhesion but reduced aggregate formation, fibrinogen binding, and activation of alpha2beta1 and alphaIIbbeta3, as detected with antibodies IAC-1 and PAC1 directed against activation-dependent epitopes of these integrins. Combined blockade of GPVI and P2Y receptors and thromboxane formation abolished integrin activation but still allowed adhesion of morphologically unstimulated, nonprocoagulant platelets. Exogenous ADP partly restored the suppressive effect of GPVI blockade on integrin alpha2beta1 and alphaIIbbeta3 activation. Adhesion was fully inhibited only with simultaneous blocking of GPVI and alpha2beta1, indicating that the integrin can support platelet-collagen binding in the absence of its activation. Blockade or absence of GPIbalpha only moderately influenced integrin activation and adhesion unless GPVI was inhibited. CONCLUSIONS: GPVI- and autocrine-released ADP induce affinity changes of alpha2beta1 and alphaIIbbeta3 during thrombus formation on collagen under flow. These integrin changes are dispensable for adhesion but strengthen platelet-collagen interactions and thereby collagen-induced platelet activation. Integrin activation during thrombus formation on collagen was studied using fluorescent-labeled antibodies IAC-1 and PAC1 directed against activation-dependent epitopes of alpha2beta1 and alphaIIbbeta3 integrin, respectively. Glycoprotein VI blockade by 9O12 antibody or P2Y ADP receptors reduced integrin activation along with aggregate formation and fibrinogen binding but not alpha2beta1-dependent adhesion. [less ▲]

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See detailValidation of two nonlinear system identification techniques using an experimental testbed
Lenaerts, V.; Kerschen, Gaëtan ULiege; Golinval, Jean-Claude ULiege et al

in Shock and Vibration (2004), 11(3-4), 365-375

The identification of a nonlinear system is performed using experimental data and two different techniques, i.e. a method based on the Wavelet transform and the Restoring Force Surface method. Both ... [more ▼]

The identification of a nonlinear system is performed using experimental data and two different techniques, i.e. a method based on the Wavelet transform and the Restoring Force Surface method. Both techniques exploit the system free response and result in the estimation of linear and nonlinear physical parameters. [less ▲]

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See detailLe coût cognitif des processus orthographiques
Schelstraete, Marie-Anne; Maillart, Christelle ULiege

in Glossa (2004), 89

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See detailLa production de gros bois de résineux : une opportunité économique et écologique?
Delahaye, L.; Colson, Vincent ULiege; Graux, G. et al

in Parcs & Réserves (2004), 59(4), 28-32

Cette note tente de faire la synthèse d'un colloque organisé par Pro Silva (Belgique-Suisse-Allemagne-France) le 17 sept. 2003 à Sasbachwalden (D) sur le thème "Gros bois résineux : une chance pour la ... [more ▼]

Cette note tente de faire la synthèse d'un colloque organisé par Pro Silva (Belgique-Suisse-Allemagne-France) le 17 sept. 2003 à Sasbachwalden (D) sur le thème "Gros bois résineux : une chance pour la sylvicultute et l'utilisation du bois". L'objectif de ce colloque était de rassembler les connaissances sur les ressources en gros bois en France, en Allemagne du Sud-Ouest et en Suisse, leurs utilisations dans l'industrie et leur évaluation en terme de biodiversité. Ce compte-rendu est complété par quelques réflexions sur la production de gros bois résineux en Région wallonne. [less ▲]

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See detailDouces transgressions : notes sur "La Perle" (H. d'Ursel, 1929)
Belloi, Livio ULiege

in Mélusine. Cahiers du Centre de Recherche sur le Surréalisme (2004), 26

Cette étude consiste en une lecture approfondie et contextualisante d’un film belge peu connu, à savoir "La Perle" (Henri d’Ursel, 1929, sur un scénario du poète Georges Hugnet). De cet examen ... [more ▼]

Cette étude consiste en une lecture approfondie et contextualisante d’un film belge peu connu, à savoir "La Perle" (Henri d’Ursel, 1929, sur un scénario du poète Georges Hugnet). De cet examen circonstancié et spécialement attentif aux phénomènes d’intertextualité, il ressort notamment que "La Perle" tranche à bien des égards avec les autres grandes œuvres cinématographiques habituellement placées sous la bannière du surréalisme (les films de Bunuel et Dali, de Germaine Dulac, de Man Ray, etc.). En particulier, le film d’Henri d’Ursel se règle sur le principe d’une transgression douce, observant apparemment les conventions narratives, mais dans le seul but de mieux les miner de l’intérieur. Rien de très spectaculaire dans "La Perle", sinon l’expression même des tiraillements intimes dont l’esthétique surréaliste se trouve affectée, entre culture populaire (référence aux "Vampires", le célèbre film à épisodes de Louis Feuillade) et raréfaction poétique (allusion à Stéphane Mallarmé et à son "Coup de dés"). [less ▲]

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See detailInventaire forestier de gestion : proposition d'un cadre méthodologique et technique
Lejeune, Philippe ULiege; Rondeux, Jacques ULiege

in Forêt Wallonne (2004), (73), 22-29

Confronté à des sollicitations de plus en plus nombreuses envers la forêt, le gestionnaire forestier doit pouvoir disposer d’informations adaptées à la complexité des analyses qu’il est amené à réaliser ... [more ▼]

Confronté à des sollicitations de plus en plus nombreuses envers la forêt, le gestionnaire forestier doit pouvoir disposer d’informations adaptées à la complexité des analyses qu’il est amené à réaliser. Les progrès récents en matière de cartographie donnent accès à une information très précieuse. L’inventaire forestier reste cependant l’outil le plus adapté pour une description, tant qualitative que quantitative, des peuplements et de leurs diverses composantes. Ces inventaires ne peuvent cependant plus se limiter au simple recensement du matériel sur pied présent au sein des différentes parcelles d’une propriété. [less ▲]

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See detailThe EU Enlargement and Russia: The Case of Kaliningrad
Petermann, Simon ULiege; Matagne, Geoffroy ULiege

in Cahiers de Sciences Politiques de l'ULg (2004), cahier n°1

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See detailCancer du pancréas et vertèbre d'ivoire
Guillaume, Thierry ULiege; Krzesinski, Jean-Marie ULiege; Lambinet, Nadine ULiege

in Revue Médicale de Liège (2004), 59(12), 685-687

En résumé, nous avons donc objectivé un adénocarcinome de la tête pancréatique cliniquement asymptomatique suite à la mise en évidence d’une lésion osseuse métastatique condensante douloureuse. Le cas ... [more ▼]

En résumé, nous avons donc objectivé un adénocarcinome de la tête pancréatique cliniquement asymptomatique suite à la mise en évidence d’une lésion osseuse métastatique condensante douloureuse. Le cas d’un adénocarcinome pancréatique révélé par une métastase osseuse surtout condensante, étant relativement rare, nous a paru intéressant à rapporter. [less ▲]

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See detailLa responsabilité des administrateurs provisoires de sociétés en cas de violation d'une obligation légale
Caprasse, Olivier ULiege

in Droit des Affaires : Revue Internationale du Droit des Affaires = Ondernemingsrecht : Internationaal Tijdschrift voor Ondernemingsrecht [= DA OR] (2004)

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See detailInfluence of breathing pattern and lung inflation on impulse oscillometry measurements in horses.
Van Erck, Emmanuelle; Votion, Dominique ULiege; Kirschvink, Nathalie et al

in Veterinary Journal (2004), 168(3), 259-69

The objective of this paper was to determine if changes in ventilation patterns could influence the outcome of respiratory function measurements performed with our impulse oscillometry system (IOS) in ... [more ▼]

The objective of this paper was to determine if changes in ventilation patterns could influence the outcome of respiratory function measurements performed with our impulse oscillometry system (IOS) in horses. In a first study, IOS tests were performed in vitro on six isolated equine lungs. Lung inflation levels were controlled by modifying depressurisation inside an artificial thorax and different ventilation patterns were imposed. In a second in vivo study, transient variations in breathing pattern were evaluated both with the IOS and a current reference technique (CRT) in five healthy mature horses after an intravenous (i.v.) injection of lobeline hydrochloride. In both studies, respiratory rate (RR, range: 7-42 breaths/min.) and tidal volume (V(T), range: 0.4-25 L) had minor or no influence on IOS parameters. The influence of lung inflation, most marked for resistance at 5 Hz (R(5 Hz)), was limited for the considered physiological range. In vivo, statistical models indicated that maximal changes in pleural pressure (Max Delta Ppl) and peak flows were the main determinants of the variability of the resistance (R(rs)) and the reactance (X(rs)) of the respiratory system. The fourfold increase in baseline Max Delta Ppl and peak flows obtained during hyperpnoea caused a significant increase in R(rs) at 5 and 10 Hz and a decrease in X(rs) at all frequencies. We conclude that IOS parameters are not influenced by tachypnoea, but will reflect alterations in respiratory mechanics caused by hyperpnoeic breathing [less ▲]

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See detailGenome scan for familial abdominal aortic aneurysm using sex and family history as covariates suggests genetic heterogeneity and identifies linkage to chromosome 19q13.
Shibamura, Hidenori; Olson, Jane M; van Vlijmen-Van Keulen, Clarissa et al

in Circulation (2004), 109(17), 2103-8

BACKGROUND: Abdominal aortic aneurysm (AAA) is a relatively common disease, with 1% to 2% of the population harboring aneurysms. Genetic risk factors are likely to contribute to the development of AAAs ... [more ▼]

BACKGROUND: Abdominal aortic aneurysm (AAA) is a relatively common disease, with 1% to 2% of the population harboring aneurysms. Genetic risk factors are likely to contribute to the development of AAAs, although no such risk factors have been identified. METHODS AND RESULTS: We performed a whole-genome scan of AAA using affected-relative-pair (ARP) linkage analysis that includes covariates to allow for genetic heterogeneity. We found strong evidence of linkage (logarithm of odds [LOD] score=4.64) to a region near marker D19S433 at 51.88 centimorgans (cM) on chromosome 19 with 36 families (75 ARPs) when including sex and the number of affected first-degree relatives of the proband (N(aff)) as covariates. We then genotyped 83 additional families for the same markers and typed additional markers for all families and obtained a LOD score of 4.75 (P=0.00014) with sex, N(aff), and their interaction as covariates near marker D19S416 (58.69 cM). We also identified a region on chromosome 4 with a LOD score of 3.73 (P=0.0012) near marker D4S1644 using the same covariate model as for chromosome 19. CONCLUSIONS: Our results provide evidence for genetic heterogeneity and the presence of susceptibility loci for AAA on chromosomes 19q13 and 4q31. [less ▲]

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See detailDate seed oil: Phenolic, tocopherol and sterol profiles
Besbes, S.; Blecker, Christophe ULiege; Deroanne, Claude ULiege et al

in Journal of Food Lipids (2004), 11(4), 251-265

Oils extracted from the seeds of two date palm (Phoenix dactylifera L) cultivars, Deglet Nour and Allig, collected from Tunisia, were compared in terms of phenolic, tocopherol and,sterol profiles. These ... [more ▼]

Oils extracted from the seeds of two date palm (Phoenix dactylifera L) cultivars, Deglet Nour and Allig, collected from Tunisia, were compared in terms of phenolic, tocopherol and,sterol profiles. These minor components are not only very important for functional properties of oils (oxidation resistance, taste, aroma and color), but could also have many health benefits. Total phenols, considered as the principal source of oil oxidation resistance, ranged from 520.81 for Deglet Nour to 220.32 mg/kg for Allig. High performance liquid chromatography revealed eight identified peaks for which the major component was hydroxytyrosol (10.21%) for Deglet Nour and tyrosol for Allig (8.10%). Total sterol content was 3500 and 3000 mg/kg for Deglet Nour and Allig, respectively. The sterol marker, beta-sitosterol, accounted for 83.31 and 78.66% of total sterols in Deglet Nour and Allig seed oils, respectively. Alpha-tocopherol was the predominant component in both date seed oils (24.97-38.85%). [less ▲]

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See detailDate seeds: chemical composition and characteristic profiles of the lipid fraction
Besbes, S.; Blecker, Christophe ULiege; Deroanne, Claude ULiege et al

in Food Chemistry (2004), 84(4), 577-584

The seeds of two date palm (Phoenix dactylifera L.) cultivars, Deglet Nour and Allig, from the Degach region-Tunisia, were analysed for their main chemical composition. Studies were also conducted on ... [more ▼]

The seeds of two date palm (Phoenix dactylifera L.) cultivars, Deglet Nour and Allig, from the Degach region-Tunisia, were analysed for their main chemical composition. Studies were also conducted on properties of oil extracted from date pits. The following values (on a dry-weight basis) were obtained for Deglet Nour and Allig cultivars, respectively: protein 5.56 and 5.17%, oil 10.19 and 12.67%, Ash 1.15 and 1.12% and total carbohydrate 83.1 and 81.0%. Gas-liquid chromatography revealed that the major unsaturated fatty acid was oleic acid (41.3-47.7%), while the main saturated fatty acid was lauric acid (17.8%) for the Deglet Nour cultivar and palmitic acid for the Allig cultivar (15.0%). Capric, myristic, myristoleic, palmitoleic, stearic, linoleic and linolenic acids were also found. Thermal profiles of both date seed oils, determined by their DSC melting curves, revealed simple thermograms. Sensorial and physical profiles of Deglet Nour and Allig seed oil were based on studies of the CieLab (L*, a*, b*) colour, oxidative stability, viscosity and microstructure. Results showed that date seed oil could be used in cosmetic, pharmaceutical and food products. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailPreparation and in vivo toxicity study of solid lipid microparticles as carrier for pulmonary administration
Sanna, V.; Kirschvink, Nathalie; Gustin, Pascal ULiege et al

in AAPS PharmScitech (2004), 5(2), 27

The purpose of this research was to investigate the effects of processing conditions on the characteristics of solid lipid microparticles (SLM) with a potential application as carriers for pulmonary ... [more ▼]

The purpose of this research was to investigate the effects of processing conditions on the characteristics of solid lipid microparticles (SLM) with a potential application as carriers for pulmonary administration. Compritol ( 5.0% wt/ wt) SLM dispersions were prepared by rotor-stator homogenization, at different surfactant concentrations and emulsification times. The SLM were characterized, in terms of morphology and size, after lyophilization and sterilization by autoclaving process. In vivo assessment was carried out in rats by intratracheal instillation of either placebo or SLM dispersion, and by bronchoalveolar lavage for cytological analysis. Mean particle size of 4 to 5 mum was achieved using 0.3% and 0.4% ( wt/ wt) of emulsifier ( Poloxamer 188) and emulsification times of 2 and 5 minutes. The particles showed spherical shape and smooth surface. The morphology of microparticles, the size, and the size distribution were not substantially modified after lyophilization and sterilization. Total cell counts showed no significant differences between placebo and SLM 0.5% or 2.5% groups. Regarding cytology, percentage of polymorphonuclear neutrophils and macrophages did not significantly differ between groups. These results suggest that a single intratracheal administration of the SLMs does not induce a significant inflammatory airway response in rats and that the SLMs might be a potential carrier for encapsulated drug via the pulmonary route. [less ▲]

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See detailEffect of haemodialysis on acoustic shear wave propagation in the skin.
Uhoda, I.; Petite, Louicette ULiege; Krzesinski, Jean-Marie ULiege et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2004), 209(2), 95-100

BACKGROUND: Diverse skin alterations may develop in patients under chronic haemodialysis. Among them, signs of premature photo-ageing have been described. AIM: To assess alterations in the physical ... [more ▼]

BACKGROUND: Diverse skin alterations may develop in patients under chronic haemodialysis. Among them, signs of premature photo-ageing have been described. AIM: To assess alterations in the physical properties of skin consistent with ageing effects and with cutaneous fluid exchanges during haemodialysis sessions. METHODS: In the first part of the study, 45 haemodialysed patients were compared to 45 age-, sex- and body-mass-index-matched healthy subjects. In the second part of the study, skin of 30 haemodialysed patients was assessed immediately before and after a haemodialysis session. The speed of ultrasound shear wave propagation was measured in each subject. Series of 16 multidirectional resonance running time measurements (RRTM) were performed on the forehead and/or the volar forearm. They were averaged for each subject. The corresponding intra-individual coefficients of variation were calculated as an estimate of the skin mechanical anisotropy. RESULTS: In both haemodialysed patients and their matched controls, RRTM values were significantly higher on the forearms than on the forehead. By contrast, no significant difference was found in RRTM values that could be ascribed to chronic haemodialysis. However, RRTM values were significantly increased as an immediate and probably transient effect of haemodialysis sessions. In healthy subjects, ageing was associated with increased RRTM values. CONCLUSION: Chronic haemodialysis does not appear to influence significantly the functional expression of the dermal ageing process. Subtle fluid movements occurring in the skin during haemodialysis sessions can be assessed by measuring non-invasively the speed of ultrasound shear wave propagation in the skin. [less ▲]

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See detailSkin compatibility of cyclodextrins and their derivatives: a comparative assessment using a corneoxenometry bioassay.
Piel, Géraldine ULiege; Moutard, S.; Uhoda, Emmanuelle ULiege et al

in European Journal of Pharmaceutics & Biopharmaceutics (2004), 57(3), 479-82

Few studies have been performed to assess the risk of skin damage by cyclodextrins (CD) and they have yielded contradictory results. The present study was conducted using the corneoxenometry bioassay on ... [more ▼]

Few studies have been performed to assess the risk of skin damage by cyclodextrins (CD) and they have yielded contradictory results. The present study was conducted using the corneoxenometry bioassay on human stratum corneum to compare the skin compatibility of CD currently used in pharmaceutical preparations (betaCD, gammaCD, Rameb, Dimeb, Trimeb, HP-betaCD and HP-gammaCD) and that of new amphiphilic CD derivatives, namely, the phospholipidyl-CD (DMPE-Dimeb and DMPE-Trimeb). All the tested CD were well tolerated by the stratum corneum at a concentration of 5%. However, inter-individual reactivity was larger for DMPE-Dimeb, suggesting a more aggressive trend for this compound. Cutaneous Index of Mildness values obtained confirm that Dimeb is able to extract some skin components and shows that DMPE-Dimeb performs similarly. [less ▲]

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See detail1903-2003. Cent ans de géographie à l’Université de Liège : changements et permanences
Merenne-Schoumaker, Bernadette ULiege

in Bulletin de la Société Géographique de Liège (2004), (44), 125-127

Address of the 100th anniversary of the Institute of Geography, University of Liege

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See detailThe effect of growth at low temperature on the activity and expression of the uncoupling protein in Acanthamoeba castellanii mitochondria.
Jarmuszkiewicz, W.; Antos, N.; swida, A. et al

in FEBS Letters (2004), 569

Mitochondria of amoeba Acanthamoeba castellanii, a non-photosynthetic soil amoeboid protozoon, possess an uncoupling protein (AcUCP) that mediates free fatty acid-activated proton re-uptake dissipating ... [more ▼]

Mitochondria of amoeba Acanthamoeba castellanii, a non-photosynthetic soil amoeboid protozoon, possess an uncoupling protein (AcUCP) that mediates free fatty acid-activated proton re-uptake dissipating the proton electrochemical gradient built up by respiration. The present study provides the first evidence that UCP could be a cold response protein in unicellulars. In mitochondria isolated from an amoeba batch culture grown temporarily at low temperature (6 degrees C), the content of AcUCP was increased and correlated with an increase in the linoleic acid (LA)-stimulated UCP-mediated carboxyatractyloside-resistant state 4 respiration, as compared to a control culture (routinely grown at 28 degrees C). Moreover, the cytochrome pathway activity was found to be insensitive to the cold exposure of amoeba cells, as indicated by respiration and membrane potential measurements as well as by an absence of change in the adenine nucleotide translocator and cytochrome oxidase expression levels. Furthermore, in mitochondria from the low-temperature-grown cells, at fixed LA concentration, the increased contribution of AcUCP activity to total mitochondrial phosphorylating respiration accompanied by lower coupling parameters was found, as was confirmed by calculation of this contribution using ADP/O measurements. [less ▲]

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See detailMitochondrial respiratory chain complex patterns from Acanthamoeba castellanii and Lycopersicon esculentum: comparative analysis by BN-PAGE and evidence of protein-protein interaction between alternative oxidase and complex III.
Navet, R.; Jarmuszkiewicz, W.; Douette, P. et al

in Journal of Bioenergetics & Biomembranes (2004), 36(5), 471-479

We have previously shown that a kinetic interplay exists between the cytochrome pathway and the alternative oxidase in mitochondria from amoeba Acanthamoeba castellanii . Native interaction analyses using ... [more ▼]

We have previously shown that a kinetic interplay exists between the cytochrome pathway and the alternative oxidase in mitochondria from amoeba Acanthamoeba castellanii . Native interaction analyses using blue native gel electrophoresis coupled to denaturating electrophoresis and immunodetection have indicated associations between alternative oxidase and oxidative phosphorylation complexes in both amoeba and tomato mitochondria. These associations are dependent on the expression level of alternative oxidase according to the physiological state in both organisms. Alternative oxidase associates broadly with large complexes of the respiratory chain when it is expressed in large amount, i.e., in ripe tomato and exponentially growing amoeba. On the contrary, alternative oxidase interacts specifically with complex III even if expression of the oxidase is low, i.e., in green tomato and stationary phase amoeba. This specific interaction represents a higher level of regulation driven by protein-protein interactions leading to a direct kinetic interplay between the cytochrome pathway and alternative oxidase in both plant and amoeba mitochondria. [less ▲]

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See detailMulti-Harmonic Modelling of Motional Magnetic Field Problems using a Hybrid Finite Element--Boundary Element Discretisation
Gyselinck, J.; Geuzaine, Christophe ULiege; Dular, Patrick ULiege et al

in Journal of Computational & Applied Mathematics (2004), 168

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See detailBoost Customer Loyalty With Online Support: The Case of Mobile Telecoms Providers
Van Riel, Allard ULiege; Lemmink, Jos; Streukens, Alexandra ULiege et al

in International Journal of Internet Marketing and Advertising (2004), 1(1), 4-23

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See detailOnline travel service quality: The role of pre-transaction services
Van Riel, Allard ULiege; Semeijn, Janjaap; Pauwels, Pieter

in Total Quality Management & Business Excellence (2004), 15(4), 475-493

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See detailClinical pharmacokinetics of once-daily molsidomine - From immediate-release to prolonged-release once-daily formulations
Herchuelz, André; Carreer-Bruhwyler, Fabienne; Crommen, Jacques ULiege et al

in American Journal of Drug Delivery (2004), 2(2), 131-141

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See detailOnderzoek en praktijk in de Franstalige neerlandistiek
Spinoy, Erik ULiege; Janssens, Guy ULiege; Sereni, Sabrina

in n/f (2004), 4

This volume collects the revised papers of the december 2003 Conference (Liège) of the Association des neerlandistes de Belgique francophone.

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See detailParavion : Hafid Bouazza tussen het particuliere en het universele
Spinoy, Erik ULiege

in Nieuwzuid (2004), 4(14), 4-14

This article is a reading of the novel Paravion by the Dutch-Moroccon novelist, focusing on the tension between the universal and the particular this novel bears witness to.

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See detailLes avances d'associé et la libération du capital: deux notions équivalentes?
Caprasse, Olivier ULiege; Aydogdu, Roman ULiege

in Revue Pratique des Sociétés Civiles et Commerciales (2004)

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See detailQuelques observations sur la qualification d'un fait en matière pénale et sur les notions d'invalidité et d'incapacité
Michiels, Olivier ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2004), 3

L'article fait le point sur la qualification d'un fait pénal par défaut et sur les principes applicables à la qualification sur opposition. Il distingue encore les notions d'invalidité et d'incapacité.

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See detail3. Chiuse poetiche e senso della fine: Spunti per una tipologia
Benzoni, Pietro ULiege

in Quaderns d'Italià (2004)

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See detailSustained vertebral fracture risk reduction after withdrawal of teriparatide in postmenopausal women with osteoporosis.
Lindsay, Robert; Scheele, Wim H; Neer, Robert et al

in Archives of Internal Medicine (2004), 164(18), 2024-30

BACKGROUND: Teriparatide (recombinant human parathyroid hormone [1-34]) reduces fracture risk in postmenopausal women with osteoporosis. We assessed the safety and incidence of new vertebral fractures ... [more ▼]

BACKGROUND: Teriparatide (recombinant human parathyroid hormone [1-34]) reduces fracture risk in postmenopausal women with osteoporosis. We assessed the safety and incidence of new vertebral fractures after withdrawal of teriparatide. METHODS: This study is a follow-up to the Fracture Prevention Trial (FPT), a randomized, placebo-controlled study of postmenopausal women with osteoporosis treated with teriparatide (20 or 40 microg) once daily for a mean of 18 months. More than 90% of the women remaining at the end of the FPT continued into the follow-up study (n = 1262). Patients and investigators were unblinded to original treatment group assignment. Women were treated according to standard clinical practice, including elective use of osteoporosis drugs. New vertebral fractures were determined by semiquantitative scoring of lateral thoracic lumbar spine radiographs 18 months after the end of the FPT. RESULTS: During the follow-up study, the reduction in fracture risk associated with previous treatment with teriparatide, 20 and 40 microg, was 41% (P = .004) and 45% (P = .001), respectively, vs placebo. The absolute reduction from the FPT baseline to the 18-month follow-up visit was 13% for both doses. Osteoporosis drugs were used by 47% of women during follow-up, with greater use in the former placebo group (P = .04); nevertheless, persistent fracture protection of previous teriparatide therapy was evident. Post hoc analysis also suggests that teriparatide treatment substantially reduced the increased risk of subsequent fracture in women who sustained a fracture during the FPT (P = .05). CONCLUSION: Vertebral fracture risk reduction by teriparatide administration persists for at least 18 months after discontinuation of therapy. [less ▲]

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See detailWavelet Applications in Surface Science: a comparison to Fourier transform.
Charles, Catherine ULiege; Rasson, Jean-Paul; Pireaux, Jean-Jacques et al

in Surface and Interface Analysis [=SIA] (2004), 36

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See detailComment j'explore...le risque cardio-vasculaire absolu a 10 ans: de Framingham 1998 a SCORE 2003.
Scheen, André ULiege

in Revue Médicale de Liège (2004), 59(7-8), 460-6

Prevention of cardiovascular diseases should primarily focus on high-risk individuals. In the absence of atherosclerosis manifestations, such persons may be screened by the calculation of the absolute ... [more ▼]

Prevention of cardiovascular diseases should primarily focus on high-risk individuals. In the absence of atherosclerosis manifestations, such persons may be screened by the calculation of the absolute risk of complications during the next ten years or extrapolated at the age of 60 years. This calculation is based upon the analysis of most important risk factors of atherosclerosis. The mode of calculation that prevailed for many years used the Framingham equation determining the absolute coronary risk (both morbidity and mortality) in the next 10 years: a risk equal or superior to 20% is considered as high and requiring specific intervention. The Third Joint Task Force of European and other Societies on cardiovascular disease prevention in clinical practice recently proposed a new mode of calculation (SCORE) based upon the absolute risk of cardiovascular (and not exclusively coronary) mortality (only fatal events and not morbidity): according to SCORE, the threshold of high risk has been set at a risk equal or superior to 5% in the next 10 years. The present article compares the two modes of calculation with their own advantages and disadvantages. [less ▲]

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See detailProtein tyrosine phosphatases in T cell physiology.
Mustelin, Tomas; Alonso, Andres; Bottini, Nunzio et al

in Molecular Immunology (2004), 41(6-7), 687-700

The molecular mechanisms of signal transduction have been the focus of intense research during the last decade. In T cells, much of the work has centered on protein tyrosine kinase-mediated signaling from ... [more ▼]

The molecular mechanisms of signal transduction have been the focus of intense research during the last decade. In T cells, much of the work has centered on protein tyrosine kinase-mediated signaling from the TCR and cytokine receptors, while the study of protein tyrosine phosphatases has lagged behind. Nevertheless, it has now become clear that many protein tyrosine phosphatases play equally important roles in T cell physiology and that no kinase-regulated system would work without the counterbalancing participation of phosphatases. In fact, we have learned that many processes are regulated primarily on the phosphatase side. This minireview summarizes the current state-of-the art in our understanding of the regulation and biology of protein tyrosine phosphatases in T lymphocyte physiology. [less ▲]

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See detailAngioplastie percutanee coronaire chez le patient diabetique. Partie 2: Espoirs apportes par les protheses endovasculaires.
Warzee, Fabian ULiege; Legrand, Victor ULiege; Scheen, André ULiege

in Revue Médicale de Liège (2004), 59(11), 653-8

Coronary artery revascularization procedures provide less favourable results in diabetic patients than in non-diabetic individuals. Especially, percutaneous coronary angioplasty (PTCA) is associated with ... [more ▼]

Coronary artery revascularization procedures provide less favourable results in diabetic patients than in non-diabetic individuals. Especially, percutaneous coronary angioplasty (PTCA) is associated with a higher rate of restenosis and recurrence of cardiac morbidity and death. In diabetic patients, PTCA should, if possible, be combined with a stent. Bare-stents allow to reduce approximately by half the risk of restenosis, but unfortunately their efficacy decreases as the vessel diameter decreases, a common finding among diabetic patients with angiopathy. ARTS ("Arterial Revascularization Therapy Study") recently showed that diabetic patients have a worse prognosis even when bare-stents are combined with PTCA as compared to non-diabetic subjects and as compared to diabetic patients treated with coronary artery bypass graft. These results open new perspectives in favour of the use of drug-eluting stents containing pharmacological agents capable of preventing restenosis. Such new stents might improve the management of diabetic patients with coronary heart disease. [less ▲]

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See detailLa loi du 6 janvier 2003 concernant les méthodes particulières de recherche et quelques autres méthodes d’enquête : un tournant dans la procédure pénale belge
Jacobs, Ann ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2004)

analyse de la loi du 6 janvier 2003 introduisant les méthodes particulières de recherche en droit belge

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See detailEvolution of blood parameters during weight loss in experimental obese Beagle dogs.
Diez, Marianne ULiege; Michaux, Charles ULiege; Jeusette, Isabelle et al

in Journal of Animal Physiology & Animal Nutrition (2004), 88(3-4), 166-71

The effects of weight loss on hormonal and biochemical blood parameters were measured monthly [carnitine, creatinine, urea, free T4 (fT4), total T4 (TT4), plasma alkaline phosphatases (ALP), aspartate ... [more ▼]

The effects of weight loss on hormonal and biochemical blood parameters were measured monthly [carnitine, creatinine, urea, free T4 (fT4), total T4 (TT4), plasma alkaline phosphatases (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), potassium and total proteins] or bimonthly [cholesterol, triglycerides, non-esterified fatty acids (NEFA), insulin-like growth factor I (IGF-I), glucose, insulin] in eight obese Beagles dogs fed either a high protein dry diet, DP (crude protein 47.5%, on dry matter basis) or a commercial high fibre diet, HF (crude protein 23.8%, crude fibre 23.3%). The dogs were allotted to two groups according to sex and body weight (BW) and they were respectively fed with the DP or the control HF diet during 12-26 weeks, until they reach their optimal BW. The plasma basal triglycerides and cholesterol concentrations were decreased by the two diets but the difference was only significant for the DP diet. The plasma mean NEFA concentration increased regularly over the period with the HF diet, without significant difference between the two diets. No effect of diet or weight loss was observed on plasma carnitine, urea, creatinine, ALP, AST, ALT, potassium, TT4, FT4, IGF-I, glucose and insulin. Weight loss induced a decrease in fT4 plasma concentration (p < 0.001). The high protein diet allowed a safe weight loss. [less ▲]

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See detailSubtype Selective Substrates For Histone Deacetylases
Heltweg, B.; Dequiedt, Franck ULiege; Marshall, Bl. et al

in Journal of Medicinal Chemistry (2004), 47(21),

To probe the steric requirements for deacylation, we synthesized lysine-derived small molecule substrates and examined structure-reactivity relationships with various histone deacetylases. Rat liver ... [more ▼]

To probe the steric requirements for deacylation, we synthesized lysine-derived small molecule substrates and examined structure-reactivity relationships with various histone deacetylases. Rat liver, human HeLa, and human recombinant class I and II histone deacetylases (HDACs) as well as human recombinant NAD(+)-dependent SIRT1 (class III enzyme) were used in these studies. A benzyloxycarbonyl substituent on the alpha-amino group yielded the highest conversion rates. Replacing the epsilon-acetyl group with larger lipophilic acyl substituents led to a pronounced decrease in conversion by class I and II enzymes; the class III enzyme displayed a greater tolerance. Incubations with recombinant FLAG-tagged human HDACs 1, 3, and 6 showed a distinct subtype selectivity among small molecule substrates. The subtype selectivity of HDAC inhibitors could be predicted with these substrates and an easily obtainable mixture of HDAC subtypes. [less ▲]

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See detailProbing the origins, diagnosis and treatment of amyloid diseases using antibodies.
Dumoulin, Mireille ULiege; Dobson, Christopher

in Biochimie (2004), 86

The deposition of proteins in the form of amyloid fibrils is the characteristic feature of more than 20 medical conditions affecting the central nervous system or a variety of peripheral tissues. These ... [more ▼]

The deposition of proteins in the form of amyloid fibrils is the characteristic feature of more than 20 medical conditions affecting the central nervous system or a variety of peripheral tissues. These disorders, which include Alzheimer's disease, the prion diseases and type II diabetes, are of enormous importance in the context of present-day human health and welfare. Extensive research is therefore being carried out to define the molecular details of the mechanism of the pathological conversion of amyloidogenic proteins from their soluble forms into fibrillar structures. This review focuses on recent studies that demonstrate the power of using antibodies or antibody fragments to probe the process of fibril formation, and discusses the emerging potential of these species as diagnostic and therapeutic agents. [less ▲]

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See detailAngioplastie percutanee coronaire chez le patient diabetique. Partie 3: Nouvelles perspectives apportees par les stents enrobes.
Warzee, Fabian ULiege; Legrand, Victor ULiege; Scheen, André ULiege

in Revue Médicale de Liège (2004), 59(12), 711-6

Coronary revascularization procedures are associated with less favourable outcomes in diabetic patients as compared to non-diabetic individuals. Especially, percutaneous coronary angioplasty (PTCA) is ... [more ▼]

Coronary revascularization procedures are associated with less favourable outcomes in diabetic patients as compared to non-diabetic individuals. Especially, percutaneous coronary angioplasty (PTCA) is associated with a high level of restenosis and recurrent cardiac morbidity and mortality. In diabetic patients, PTCA should ideally be combined with stents. Bare-metal stents reduce by almost half the risk of restenosis, but this favourable effect decreases with the vessel calibre, a common finding in diabetic patients. Drug-eluting stents containing pharmacological agents that can reduce the risk of restenosis (sirolimus, paclitaxel) provide better angiographic results, including in small coronary arteries, and this effect has been shown to be accompanied by significant reduction of both morbidity and mortality. Such preliminary results obtained in the general population (including around 20% of diabetic subjects) deserve further confirmation in a large clinical trial specifically devoted to diabetic patients. Drug-eluting stents may represent a major advance in the management of diabetic patients with coronary heart disease in the near future. [less ▲]

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See detailL'etude clinique du mois. INTERHEART": la preuve par 9. Neuf facteurs de risque predisent neuf infarctus du myocarde sur dix."
Scheen, André ULiege; Kulbertus, Henri ULiege

in Revue Médicale de Liège (2004), 59(11), 676-9

INTERHEART is a standardised case-control study of acute myocardial infarction in 52 countries representing every inhabited continent. 15152 cases and 14820 controls were enrolled. Collectively, 9 factors ... [more ▼]

INTERHEART is a standardised case-control study of acute myocardial infarction in 52 countries representing every inhabited continent. 15152 cases and 14820 controls were enrolled. Collectively, 9 factors accounted for 90% of myocardial infarctions in men and 94% in women. These factors were 6 risk factors (dyslipidaemia characterized by high apoB/apoA1 ratio, smoking, hypertension, diabetes mellitus, abdominal obesity and stressful psychosocial factors) and 3 protective factors (daily consumption of fruits and vegetables, regular alcohol consumption, and regular physical activity). These findings suggest that interventions targeting these 9 factors have the potential to prevent most premature cases of myocardial infarction and that these strategies should be implemented worldwide. [less ▲]

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See detailAdaptation et test d'un nez électronique pour suivre en continu la nuisance olfactive générée par un centre de compostage
Ledent, Catherine; Dauby, B.; Nicolas, Jacques ULiege et al

in Revue scientifique des instituts supérieurs industriels libres francophones (2004), 18

L'article présente le travail de fin d'études de Catherine Ledent. Celui-ci a consisté à la mise au point et au test sur le terrain (sur le centre de compostage à Habay) d'un nez électronique destiné à ... [more ▼]

L'article présente le travail de fin d'études de Catherine Ledent. Celui-ci a consisté à la mise au point et au test sur le terrain (sur le centre de compostage à Habay) d'un nez électronique destiné à être placé en continu sur un site industriel, de manière à détecter des occurrences d'odeur. Le prototype existant a été adapté de manière à satisfaire aux exigences du terrain. Par exemple, une régulation thermique de la chambre des capteurs a permis de s'affranchir des variations de température de l'ambiance. La phase de validation sur le terrain fut la plus exigeante: elle nécessitait en effet une présence constante de l'étudiante sur le terrain, de manière à identifier les causes possibles de variation des capteurs. En finale, le système a montré d'excellentes performances et peut servir de base à un développement technologique ultérieur. [less ▲]

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See detailSuppression Of Tumor Growth And Cell Proliferation By P13(Ii), A Mitochondrial Protein Of Human T Cell Leukemia Virus Type 1
Silic-Benussi, M.; Cavallari, L.; Zorzan, T. et al

in Proceedings of the National Academy of Sciences of the United States of America (2004), 101(17),

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See detailCyclodextrins as a potential carrier in drug nebulization.
Evrard, Brigitte ULiege; Bertholet, P.; Guéders, Maud ULiege et al

in Journal of Controlled Release (2004), 96(3), 403-10

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the ... [more ▼]

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the feasibility of using different cyclodextrins (CDs) to elaborate pharmaceutical formulations for the inhalation route and tested the short-term toxicity of such formulations administered by inhalation to C57BL/6 mice. We have shown that HP-beta-CD, gamma-CD, as well as RAMEB aqueous solutions can undergo aerosolization and that the resulting droplet-size ranges are compatible with pulmonary deposition. In vivo, we have demonstrated that short-term exposure to inhaled HP-beta-CD, gamma-CD and RAMEB solutions are non-toxic after assessing bronchoalveolar lavage (BAL), lung and kidney histology, bronchial responsiveness to methacholine and blood urea. The only change noted is a slight increase in lymphocyte count in the BAL after HP-beta-CD and gamma-CD inhalation. We conclude that CDs are useful in significantly enhancing the solubility of apolar drugs with a view to inhalation therapy although an increase in lymphocyte counts in the BAL after CDs inhalations needs further investigations. [less ▲]

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See detailGas chromatography-olfactometry analysis of beef meat originating from differently fed Belgian Blue, Limousin and Aberdeen Angus bulls
Machiels, D.; Istasse, Louis ULiege; van Ruth, S. M.

in Food Chemistry (2004), 86(3), 377-383

The volatile compounds of cooked meats from differently fed Belgian Blue, Limousin and Aberdeen Angus bulls were isolated in a model mouth apparatus. Their odour activity was determined by gas ... [more ▼]

The volatile compounds of cooked meats from differently fed Belgian Blue, Limousin and Aberdeen Angus bulls were isolated in a model mouth apparatus. Their odour activity was determined by gas chromatography-olfactometry based on a detection frequency method. A total of thirty compounds possessed an odour activity in cooked beef meat. Significant influences of breed and diet on the development of the odour-active compounds of cooked beef meat were observed. The meat of Belgian Blue seemed to generate more odour-active compounds and to be more influenced by the feeding diet than the other breeds. This could be the consequence, at least in part, of its double-muscle condition. However, no obvious justifications could be given to explain the influence of the diet. Different chemical compositions are factors of importance for explaining the different aroma profiles between breeds, but some other parameters should also play an important role. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailCommunity-based wildlife management in Burkina Faso : the experiments of the Nazinga Ranch and W park
Vermeulen, Cédric ULiege

in Game and Wildlife Science (2004), 21(3), 313-326

Le Burkina Faso reste le seul pays d’Afrique occidentale à posséder une législation où, au moins légalement, la gestion cynégétique de la faune sauvage par les populations locales est devenue une réalité ... [more ▼]

Le Burkina Faso reste le seul pays d’Afrique occidentale à posséder une législation où, au moins légalement, la gestion cynégétique de la faune sauvage par les populations locales est devenue une réalité. Les textes de loi prévoient en effet la possibilité pour les populations de délimiter sur leurs terroirs des zones dévolues à la chasse commerciale, d’y faire venir des chasseurs et de rétrocéder à l’État la part des recettes qui lui est due. La loi prévoit également la constitution de Comités Villageois de Gestion de la Faune (CVGF), structures rattachées aux Comités Villageois de Gestion de Terroir (CVGT) et reconnues dans le processus de décentralisation en cours. L’opportunité de construire une conservation de la faune sauvage servant directement le développement local existe donc. Dans la pratique, il reste encore beaucoup d’étapes à franchir avant que des Zones Villageoises d’Intérêt Cynégétique (ZOVIC) réellement autonomes et indépendantes financièrement ne prennent corps. Les résistances au niveau institutionnel et privé ne manquent pas, et seule la démonstration de la capacité des populations locales à relever ce défi pourra faire évoluer les mentalités. Les premières ZOVIC ont été mises en place à partir de 2000 dans les périphéries du Ranch de Nazinga (1 276 ha de ZOVIC) et du Parc du W (1 790 ha de ZOVIC). Ces expériences ont été la source de riches enseignements dans des contextes particuliers de tensions foncières, liés soit à une importante immigration humaine dans le cas de la ZOVIC du Ranch de Nazinga, soit à une course au coton dans celui des ZOVIC du Parc du W. Elles ont montré que la gestion cynégétique villageoise nécessitait des besoins de formation importants et qu’elle devait faire face aux classiques enjeux techniques (préservation de l’habitat, gestion de la faune, quotas d’abattage dont l’application reste parfois aléatoire en raison de la petite taille des zones délimitées, etc.). Les ZOVIC ont aussi soulevé le problème du rapport de la communauté rurale à l’espace et au foncier, celui fonctionnement des structures locales de gestion et de leur fusion avec le système politique coutumier local, et celui de la réelle volonté de l’univers administratif et privé de la chasse à partager la rente cynégétique avec les populations locales. La gestion cynégétique villageoise doit donc être comprise comme un exercice de démocratie directe et comme la voie vers la gestion globale des terroirs villageois. Au-delà de l’aspect technique lié à la faune et à sa gestion durable, la réussite de ces expériences devrait également annoncer la pratique d’une chasse plus sociale et plus équitable, où les populations locales participeraient davantage au partage du flux financier. [less ▲]

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See detailAngioplastie percutanee coronaire chez le patient diabetique Partie 1 : echecs relatifs lies a la restenose apres angioplastie simple.
Warzee, Fabian ULiege; Legrand, Victor ULiege; Scheen, André ULiege

in Revue Médicale de Liège (2004), 59(10), 584-90

Diabetes mellitus, essentially type 2 diabetes, is markedly associated with a high risk of cardiovascular diseases, especially coronary artery disease (CAD). Revascularization techniques, first coronary ... [more ▼]

Diabetes mellitus, essentially type 2 diabetes, is markedly associated with a high risk of cardiovascular diseases, especially coronary artery disease (CAD). Revascularization techniques, first coronary artery bypass graft (CABG) and second percutaneous transluminal coronary angioplasty (PTCA), have drastically changed the management of patients with CAD. Unfortunately, overall results of such revascularization procedures are less impressive in diabetic patients than in nondiabetic subjects, because of a worse vascular bed due to a more diffuse disease including small vessels. The diabetic population is indeed characterized by higher rates of both post-CABG thrombosis and post-PTCA restenosis, as compared to the corresponding rates observed in a nondiabetic population. Such vascular complications result in a higher incidence of coronary events leading to greater morbidity and mortality in both the short (weeks-months) and long (years) term. The bad quality of blood glucose control appears to play a crucial role in the risk of restenosis and further complications. The use of endovascular stents, especially new drug-eluting stents reducing the risk of restenosis, may represent a new opportunity for the management of a high-risk population such as diabetic patients. [less ▲]

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See detailRetrait du rofecoxib (Vioxx): a propos de la securite cardiovasculaire des anti-inflammatoires non steroidiens cox-2 selectifs.
Scheen, André ULiege

in Revue Médicale de Liège (2004), 59(10), 565-9

Rofecoxib (Vioxx), the first COX-2 selective non-steroidal anti-inflammatory drug (NSAID), was recently withdrawn by Merck Sharp & Dohme. Indeed, both observational studies and randomised clinical trials ... [more ▼]

Rofecoxib (Vioxx), the first COX-2 selective non-steroidal anti-inflammatory drug (NSAID), was recently withdrawn by Merck Sharp & Dohme. Indeed, both observational studies and randomised clinical trials showed that rofecoxib is associated with a significantly increased risk of acute myocardial infarction in patients receiving either high daily dosage (>25 mg/day) or for a long period of time (> 18 months). The precise mechanism responsible for this phenomenon still remains unknown. Currently available data suggest that this adverse effect is not observed with other COX-2 NSAIDs, especially celecoxib for which the information is most abundant. Nevertheless, caution is required because of lack of prospective long-term data, and strict respect of indications and modalities of clinical use of COX-2 NSAIDs is mandatory. Finally, in patients with high cardiovascular risk who should receive a COX-2 selective NSAID, the association with a low dose of acetylsalicylic acid is recommended in order to benefit of a protective antiplatelet effect. [less ▲]

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See detailInfo-congres. Effets d'une insulinotherapie intensive apres un infarctus du myocarde chez le patient diabetique de type 2 : resultats de l'etude DIGAMI-2.
Scheen, André ULiege; Radermecker, Régis ULiege; Philips, Jean-Christophe ULiege

in Revue Médicale de Liège (2004), 59(9), 534-9

The results of DIGAMI-2 (<<Diabetes Mellitus Insulin Glucose Infusion in Acute Myocardial Infarction>>) trial were presented at the 40th scientific congress of the European Association for the Study of ... [more ▼]

The results of DIGAMI-2 (<<Diabetes Mellitus Insulin Glucose Infusion in Acute Myocardial Infarction>>) trial were presented at the 40th scientific congress of the European Association for the Study of Diabetes (EASD) in Munich on September 6, 2004. The main objective of this multicentre international trial was to confirm the positive results of the first DIGAMI trial published in 1995--1997. This pilot trial demonstrated that insulin-glucose infusion followed by a subcutaneous multidose insulin regimen reduces total mortality after 1 and 3 years in diabetic patients with acute myocardial infarction. DIGAMI-2, by comparing three groups of subjects receiving various interventions, aimed at determining the relative benefit resulting from the insulin-glucose infusion in the acute phase and that attributable to long-term intensive insulin therapy in a similar population of type 2 diabetic patients. No significant difference was observed between the three groups as far as total mortality and cardiovascular morbidity were concerned. These negative results may be explained by the absence of significant difference in blood glucose control between the three groups, by the fact that glycaemic targets were not reached in the intensive group and, last but not least, by a better management of other risk factors, allowing already markedly reduced cardiovascular morbidity and mortality in the reference group treated with conventional antidiabetic therapy. In conclusion, DIGAMI-2 argues for a multidisciplinary management of diabetic patients to reach strict glycaemic targets with an intensive insulin scheme and confirms the remarkable advances in cardiovascular protection thanks to an optimised global pharmacological approach combined with modern revascularisation procedures. [less ▲]

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See detailUne matrice conceptuelle de la négociation. Du marchandage à la négociation valorielle
Kuty, Olgierd ULiege

in Négociations (2004), 1(1), 45-62

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See detailIndication of the uplift of the Ardenne in long-term gravity variations in Membach (Belgium)
Francis, Olivier; Van Camp, Michel; van Dam, Tonie et al

in Geophysical Journal International (2004), 158

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See detailEmotional processing in a non-clinical psychosis-prone sample
Van't Wout, M.; Aleman, A.; Kessels, R. P. C. et al

in Schizophrenia Research (2004), 68

Symptoms of psychosis have been proposed to form part of a continuous distribution of experiences in the general population rather than being an all-or-nothing phenomenon. Indeed, schizotypal signs have ... [more ▼]

Symptoms of psychosis have been proposed to form part of a continuous distribution of experiences in the general population rather than being an all-or-nothing phenomenon. Indeed, schizotypal signs have been reported in subjects from nonclinical samples. Emotional processing has been documented to be deficient in schizophrenia. In the present study, we tested the hypothesis whether putatively psychosis-prone subjects would show abnormalities in emotion processing. Based on the extremes of Launay-Slade Hallucination Scale (LSHS) ratings of 200 undergraduate students, two groups of subjects (total N= 40) were selected. All 40 participants filled in the Schizotypal Personality Questionnaire (SPQ). We compared both groups on an alexithymia questionnaire and on four behavioral emotional information processing tasks. Hallucination-proneness was associated with an increased subjective emotional arousal and fantasy-proneness. Although no differences between the high and low group were observed on three behavioral emotion processing tasks, on the affective word-priming task presentation of emotional stimuli was associated with longer reactions times to neutral words in high schizotypal subjects. Also, SPQ scores correlated with several emotion processing tasks. We conclude that these findings lend partial support to the hypothesis of continuity between symptoms characteristic of schizophrenia and psychosis-related phenomena in the normal population. (C) 2003 Elsevier B.V All rights reserved. [less ▲]

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See detailFurther evidence of the multi-dimensionality of hallucinatory predisposition: factor structure of a modified version of the Launay-Slade Hallucinations Scale in a normal sample
Laroi, Frank ULiege; Marczewski, P.; Van der Linden, Martial ULiege

in European Psychiatry (2004), 19

Recent years has seen an increasing interest in the hallucinatory experience, including investigations of its phenomenological prevalence and character both in pathological and normal (predisposed ... [more ▼]

Recent years has seen an increasing interest in the hallucinatory experience, including investigations of its phenomenological prevalence and character both in pathological and normal (predisposed) populations. We investigated the multi-dimensionality of hallucinatory experiences in 265 subjects from the normal population, who completed a modified version of the Launay-Slade Hallucinations Scale. Principal components analysis was performed on the data. Four factors were obtained loading on items reflecting (1) sleep-related hallucinatory experiences (2) vivid daydreams (3) intrusive thoughts or realness of thought and (4) auditory hallucinations. The results offer further evidence of the multi-dimensionality of hallucinatory disposition in the normal population. Directions for future research in hallucinatory predisposition are discussed. <LF>(C) 2003 Elsevier SAS. All rights reserved. [less ▲]

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See detailLe coma hypoglycemique, un phenomene paroxystique redoute chez le patient diabetique de type 1.
Radermecker, Régis ULiege; Scheen, André ULiege

in Revue Médicale de Liège (2004), 59(5), 265-9

The hypoglycaemic coma is a severe complication for type 1 diabetic patients. Rarely fatal it may be associated with various paroxysmal accidents, potentially harmful, especially during driving ... [more ▼]

The hypoglycaemic coma is a severe complication for type 1 diabetic patients. Rarely fatal it may be associated with various paroxysmal accidents, potentially harmful, especially during driving. Hypoglycaemia certainly alters the quality of life because it markedly increases the anxiety of both the patient and his/her family. It is considered as a major limiting factor in the glycaemic management of type 1 diabetic patients. Being the consequence of numerous causal factors, hypoglycaemic coma is not always easy to prevent and may occur as a paroxysmal phenomenon, sometimes without obvious contributing circumstances. After having defined the various hypoglycaemic thresholds, we will analyse the pathophysiology of insulin-induced hypoglycaemia and of its hormonal counterregulation, and we will describe the hypoglycaemia unawareness phenomenon. These elements should help to better understand why a hypoglycaemic coma may suddenly occur in a diabetic patient. Some advices will also be given to reduce the risk of such a paroxysmal complication in patients with type 1 diabetes. [less ▲]

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See detailThe Bryophyte Layer In A Calcareous Grassland After A Decade Of Contrasting Mowing Regimes
Vanderpoorten, Alain ULiege; Delescaille, Lm.; Jacquemart, Al.

in Biological Conservation (2004), 117(1),

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See detailLes modes alternatifs de règlement des différends: anges ou démons?
Caprasse, Olivier ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2004)

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See detailTransposition de la Directive Nitrate (CE) en Région wallonne : azote potentiellemnt lessivable de référence pour les sols cultivés en Région wallonne
Vandenberghe, Christophe ULiege; Marcoen, Jean Marie ULiege

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2004), 8

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See detailCompte rendu de : Last Things, Death & the Apocalypse
Donneau, Olivier ULiege

in Moyen Age (Le) (2004), 110

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See detailInfo-congres. Optimalisation de la prise en charge du patient diabetique: une selection de quelques essais cliniques presentes au Congres 2004 de l'American Diabetes Association.
Scheen, André ULiege; Radermecker, Régis ULiege; Philips, Jean-Christophe ULiege

in Revue Médicale de Liège (2004), 59(6), 407-12

The 64th scientific congress of the American Diabetes Association had a special session devoted to the presentation of the results from three clinical trials: 1) the first multicentre international trial ... [more ▼]

The 64th scientific congress of the American Diabetes Association had a special session devoted to the presentation of the results from three clinical trials: 1) the first multicentre international trial of pancreatic islet transplantation according to the so-called Edmonton protocol with the primary endpoint of restoring insulin independence in type 1 diabetic patients; 2) three pivotal studies of 30 weeks testing both the efficacy and safety of exenatide (exendin-4), a new insulin secretagogue that is a long-acting analogue of glucagon-like peptide-1, in patients with type 2 diabetes treated with either metformin, or a sulfonylurea, or a metformin-sulfonylurea combination; and 3) the "Collaborative AtoRvastatin Diabetes Study" (CARDS), a placebo-controlled primary prevention trial of cardiovascular complications using atorvastatin 10 mg in 2 838 at risk patients with type 2 diabetes. The main results and conclusions of these trials are briefly presented as they open new perspectives in the management of patients with type 1 or type 2 diabetes mellitus. [less ▲]

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See detailDistribution of bacteria and associated minerals in the gill chamber of the vent shrimp Rimicaris exoculata and related biogeochemical processes
Zbinden, M.; Le Bris, N.; Gaill, F. et al

in Marine Ecology. Progress Series (2004), 284

The shrimp Rimicaris exoculata dominates the megafauna of some Mid-Atlantic Ridge hydrothermal vent fields. This species harbours a rich bacterial epibiosis inside its gill chamber. At the 'Rainbow' vent ... [more ▼]

The shrimp Rimicaris exoculata dominates the megafauna of some Mid-Atlantic Ridge hydrothermal vent fields. This species harbours a rich bacterial epibiosis inside its gill chamber. At the 'Rainbow' vent site (36degrees 14.0'N), the epibionts are associated with iron oxide deposits. Investigation of both bacteria and minerals by scanning electron microscopy (SEM) and X-ray microanalysis (EDX) revealed 3 distinct compartments in the gill chamber: (1) the lower pre-branchial chamber, housing bacteria but devoid of minerals; (2) the 'true' branchial chamber, containing the gills and devoid of both bacteria and minerals; and (3) the upper pre-branchial chamber, housing the main ectosymbiotic bacterial community and associated mineral deposits. Our chemical and temperature data indicated that abiotic iron oxidation appears to be kinetically inhibited in the environment of the shrimps, which would explain the lack of iron oxide deposits in the first 2 compartments. We propose that iron oxidation is microbially promoted in the third area. The discrepancy between the spatial distribution of bacteria and minerals suggests that different bacterial metabolisms are involved in the first and third compartments. A possible explanation lies in the modification of physico-chemical conditions downstream of the gills that would reduce the oxygen content and favours the development of bacterial iron-oxidizers in this Fe-II-rich environment. A potential role of such iron-oxidizing symbionts in the shrimp diet is suggested. This would be unusual for hydrothermal ecosystems, in which most previously described symbioses rely on sulphide or methane as an energy source. [less ▲]

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See detailGibberellins and the floral transition in Sinapis alba
Corbesier, Laurent; Kustermans, Gaëlle ULiege; Périlleux, Claire ULiege et al

in Physiologia Plantarum (2004), 122(1), 152-158

The putative role of gibberellins in the transition to flowering was investigated in Sinapis alba, a caulescent long-day (LD) plant. It was observed that: (1) physiological doses of exogenous gibberellins ... [more ▼]

The putative role of gibberellins in the transition to flowering was investigated in Sinapis alba, a caulescent long-day (LD) plant. It was observed that: (1) physiological doses of exogenous gibberellins (GA(1), GA(3), GA(9)) do not cause the floral shift of the meristem when applied to plants grown in short days but have some positive effect on the flowering response to a suboptimal LD; no inhibition was observed in any case; (2) GA-biosynthesis inhibitors (prohexadione-Ca and paclobutrazol) considerably inhibit stem growth but have some negative effect on flowering only when a suboptimal LD is given; and (3) the floral transition induced by one 22-h LD does not correlate with any detectable change in GA content of the apical bud, of the leaves, and of the phloem exudate reaching the apex. Taken together, these results suggest that GAs do not act as a major signal for photoperiodic flower induction in Sinapis. [less ▲]

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See detailL’enseignement et la connaissance de la matière des professeurs d’EPS. Le cas de la natation dans un lycée de l’agglomération grenobloise
Attikleme, Kossivi; Tanimomo, Libéral; Cloes, Marc ULiege et al

in Revue de l'Education Physique (2004), 44(3), 83-93

Le but de cette étude est de montrer, d'une part, dans le système éducatif français, les diverses transformations ou modifications que les enseignants d'EPS font subir aux pratiques sportives lorsqu'ils ... [more ▼]

Le but de cette étude est de montrer, d'une part, dans le système éducatif français, les diverses transformations ou modifications que les enseignants d'EPS font subir aux pratiques sportives lorsqu'ils ont la volonté de les enseigner et, d'autre part, de mettre en évidence la connaissance de la nage qui caractérise chacun d'eux ou qui sous-tend le processus de transformation qu'ils opèrent en matière d'enseignement. C'est en effet un processus qui n'est pas spécifique au système éducatif français organisé au collège en cycles d'étude. ... [less ▲]

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See detailActualites therapeutiques 2003-2004.
Scheen, André ULiege

in Revue Médicale de Liège (2004), 59(6), 385-402

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule and ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule and its modalities of appropriate use in clinical practice will be emphasized. Both the efficacy and safety of these new drugs have been evaluated in randomised controlled trials according to the evidence-based-medicine criteria. Most of them are currently studied in order to further demonstrate their potential benefit on a long-term basis, in large cohort of patients and using hard clinical endpoints. [less ▲]

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See detailIs the western population of the European mink, (Mustela lutreola), a distinct Management Unit for conservation?
Michaux, Johan ULiege; Libois, Roland ULiege; Davison, A. et al

in Biological Conservation (2004), 115(3), 357-367

The European mink (Mustela lutreola) is one of the most threatened carnivores in Europe, with fragmented populations in Belarus. Russia and Romania, as well in south-western France and northern Spain ... [more ▼]

The European mink (Mustela lutreola) is one of the most threatened carnivores in Europe, with fragmented populations in Belarus. Russia and Romania, as well in south-western France and northern Spain. Many populations have become extinct recently, or are declining. We investigated mitochondrial DNA variation, using the complete D-loop region, and concentrating oil the west European population. The aim was two-fold: to use the genetic information to advise on the conservation of European mink, and to begin to understand their history through the Pleistocene. Captive breeding and re-introduction programmes are underway, so it is particularly vital to know whether the West European population should be treated separately. We find that European mink probably colonised from a single refugium after the last glaciation. West European populations may be fixed for a single haplotype. also suggesting a common origin. Despite this evidence for gene flow, following the precautionary principle we suggest that mink from the three geographically separate populations (Romania, Eastern and Western Europe) should be managed separately, for the moment. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailThe Pyoverdins Of Pseudomonas Syringae And Pseudomonas Cichorii
Bultreys, A.; Gheysen, I.; Wathelet, Bernard ULiege et al

in Zeitschrift Fur Naturforschung C-A Journal of Biosciences (2004), 59(9-10),

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See detailPersonality profile and drug of choice; a multivariate analysis using Cloninger's TCI on heroin addicts, alcoholics, and a random population group.
Le Bon, O.; Basiaux, P.; Streel, E. et al

in Drug and Alcohol Dependence (2004), 73(2), 175-82

As personality may predispose, precipitate or perpetuate substance abuse and/or dependence, and as it is considered to remain stable across the years in a given subject, potential links with the drug of ... [more ▼]

As personality may predispose, precipitate or perpetuate substance abuse and/or dependence, and as it is considered to remain stable across the years in a given subject, potential links with the drug of choice may help screen future patients before drug consumption. The present study compared three groups: 42 patients with heroin dependence (mean age: 31.2; standard deviation (SD): 5.5; 10 females), 37 patients with alcohol dependence (mean age 44.2; SD: 9.1; 9 females) and 83 subjects from a random population sample (mean age: 38.8; SD: 6.9; 20 females). Personality was measured by Cloninger's Temperament and Character Inventory (TCI). Pillai's MANCOVA with age as a covariate and gender as a cofactor was highly significant. Univariate ANOVA analyses using TCI dimensions as dependent variable showed most variables to vary in parallel for the two patient groups in comparison with controls. Post-hoc tests showed heroin patients to score higher in Novelty-Seeking and Self-Directedness than alcohol patients. Sub-dimensions Exploratory Excitability, Fear of the Uncertain, Responsibility, Congruent Second Nature and Transpersonal Identification were also significantly different in the two patient samples. Logistic regression showed Exploratory Excitability to segregate up to 76% of heroin patients from alcohol patients. In conclusion, personality profiles were linked to some preferential choice of drug and personality screening might be tested in preventive strategies. [less ▲]

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