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See detailLe cas clinique du mois. La syphilis, une MST de retour en nos murs.
Flagothier, Caroline ULiege; Arrese Estrada, Jorge ULiege; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2004), 59(7-8), 426-9

Sexually transmitted diseases (STD) show frequent epidemiological changes. We report a case of secondary syphilis diagnosed in a 32-year old woman during post-partum. The disease, although showing a ... [more ▼]

Sexually transmitted diseases (STD) show frequent epidemiological changes. We report a case of secondary syphilis diagnosed in a 32-year old woman during post-partum. The disease, although showing a typical presentation, raises the problem of dating with precision the contamination time. This is of importance for treating the newborn at risk of congenital syphilis. We highlight the constant attention that should be brought to disclose this venereal disease that shows so variable clinical and histological presentations. Syphilis seems on the rise in the Mosan valley and in some cities where prostitution is imported from Eastern Europe and Africa. [less ▲]

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See detailFrontières en Afrique centrale : gage de souveraineté ?
Kabamba, Bob ULiege

in Fédéralisme - Régionalisme (2004), volume 4

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See detailLe bilan azoté dans les exploitations porcines wallonnes : entre contraintes environnementales et qualité différenciée.
Degre, Aurore ULiege; Verheve, Didier; Debouche, Charles ULiege

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2004), 8(2), 119-124

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See detailIncorporation of a Jiles-Atherton vector hysteresis model in 2D FE magnetic field computations - Application of the Newton-Raphson method
Gyselinck, Johan; Dular, Patrick ULiege; Sadowski, Nelson et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2004), 23(3), 685-693

his paper deals with the incorporation of a vector hysteresis model in 2D finite-element (FE) magnetic field calculations. A previously proposed vector extension of the well-known scalar Jiles-Atherton ... [more ▼]

his paper deals with the incorporation of a vector hysteresis model in 2D finite-element (FE) magnetic field calculations. A previously proposed vector extension of the well-known scalar Jiles-Atherton model is considered The vectorised hysteresis model is shown to have the same advantages as the scalar one: a limited number of parameters (which have the same value in both models) and ease of implementation The classical magnetic vector potential FE formulation is adopted Particular attention is paid to the resolution of the nonlinear equations by means of the Newton-Raphson method It is shown that the application of the latter method naturally leads to the use of the differential reluctivity tensor, i.e. the derivative of the magnetic field vector with respect to the magnetic induction vector. This second rank tensor can be straightforwardly calculated for the considered hysteresis model. By way of example, the vector Jiles-Atherton is applied to two simple 2D FE models exhibiting rotational flux. The excellent convergence of the Newton-Raphson method is demonstrated. [less ▲]

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See detailExploration isocinétique de l’avant-bras et du poignet. Méthodologie et application à une pathologie tendineuse
Forthomme, Bénédicte ULiege; Croisier, Jean-Louis ULiege; Foidart-Dessalle, Marguerite ULiege et al

in Journal de Traumatologie du Sport (2004), 21(2), 80-87

Relatively little is known about isokinetic profiles of the forearm and wrist muscles. The aims of the study were therefore to prove the reproducibility of the measurements, to establish reference ... [more ▼]

Relatively little is known about isokinetic profiles of the forearm and wrist muscles. The aims of the study were therefore to prove the reproducibility of the measurements, to establish reference concentric and eccentric strength values and to determine the effectiveness of an isokinetic eccentric training model in treating chronic epicondylitis. The concentric and eccentric assessment of healthy male and female subjects allowed the analysis of different parameters: absolute and bodyweight normalized peak torque; bilateral asymmetries and conventional pronator / supinator and flexor / extensor ratios. We have studied the coefficients of variation in a test – retest session. At the same time, 32 patients diagnosed with chronic lateral epicondylitis benefited from an adapted isokinetic eccentric training model (20 to 30 sessions). The absolute reliability in repeated tests procedure of peak torque measurement appeared satisfactory with CV inferior to 12 %. The bilateral asymmetries did not exceed 24 %. PT ratio study reflected the superiority of the PRO and FLE muscles in comparison to the opposite groups. The eccentric rehabilitative model presented a very satisfactory effect on treating chronic epicondylitis with a significant reduction of pain (Visual Analogic Scale), improvement in the ultrasonographic examination (normalized echoic aspect in 53 % of cases) and normalization of maximal isokinetic strength. The isokinetic testing of the forearm pronosupinator muscles and wrist flexor-extensor muscles appeared reproducible. Referential values were proposed for different parameters allowing easier interpretation of pathological cases. The isokinetic eccentric rehabilitative model promoted the epicondylitis treatment. [less ▲]

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See detailModelling and analysis of a MEMS approach to dc voltage step-up conversion
Haas, C. H.; Kraft, Michaël ULiege

in Journal of Micromechanics and Microengineering (2004), 14(9), 114-122

This paper studies the principle of a novel voltage step-up converter based on a micromachined variable parallel-plate capacitor in combination with an electrostatic actuator. Electrical equivalent ... [more ▼]

This paper studies the principle of a novel voltage step-up converter based on a micromachined variable parallel-plate capacitor in combination with an electrostatic actuator. Electrical equivalent circuit and system-level SIMULINK models have been developed. Based on these models, an analysis of design parameters and expected device performance has been performed to serve as a starting point for a prototype implementation. Possible areas of application are self-powered, stand-alone sensing systems, aerospace applications and any kind of electrostatic or piezoelectric MEMS devices in general. [less ▲]

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See detailLes toxidermies paroxystiques graves.
Paquet, Philippe ULiege; Flagothier, Caroline ULiege; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2004), 59(5), 286-92

Some drug reactions showing cutaneous expression exhibit a paroxysmal course. These diseases encompass the toxic epidermal necrolysis, the drug hypersensitivity syndrome, and the acute generalized ... [more ▼]

Some drug reactions showing cutaneous expression exhibit a paroxysmal course. These diseases encompass the toxic epidermal necrolysis, the drug hypersensitivity syndrome, and the acute generalized exanthematic pustulosis. These syndromes are associated with dismal outcome. They represent medical emergencies needing hospitalization in specialized care units. [less ▲]

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See detailPROBA II payload: a Belgian mini space weather observatory
Rochus, Pierre ULiege; Defise, Jean-Marc ULiege; Lecat, Jean-Hervé ULiege et al

in IAC Papers (2004), 5

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See detailEvaluation of immunogenicity and protective efficacy of a Microsporum canis metalloprotease subunit vaccine in guinea pigs.
Vermout, Sandy M; Brouta, Frederic D; Descamps, Frederic F et al

in FEMS Immunology & Medical Microbiology (2004), 40(1), 75-80

In order to identify protective immunogens against Microsporum canis infection, a purified recombinant keratinolytic metalloprotease (r-MEP3) was tested as a subunit vaccine in experimentally infected ... [more ▼]

In order to identify protective immunogens against Microsporum canis infection, a purified recombinant keratinolytic metalloprotease (r-MEP3) was tested as a subunit vaccine in experimentally infected guinea pigs. Both humoral and cellular specific immune responses developing towards r-MEP3 were evaluated, by enzyme-linked immunosorbent assay and by in vitro lymphocyte transformation tests respectively. Vaccination induced a strong antibody response, and a significant but transient lymphoproliferative response against the protein. However, the protocol failed to prevent fungal invasion or development of dermatophytic lesions. These results show that under the present experimental conditions, r-MEP3 specific antibodies are not protective against a challenge exposure. They also suggest that in the same model, the induction of cell-mediated immunity towards r-MEP3 is not sufficient, indicating the need for further research in the field of specific immune mechanisms involved in M. canis dermatophytosis. [less ▲]

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See detailLa répression de la mendicité en 2004. Observations sous Pol. Bruxelles, 27 janvier 2004
Fierens, Jacques ULiege

in Journal des Tribunaux (2004)

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See detailImpact of low frequency transcranial magnetic stimulation on event-related brain potentials.
Hansenne, Michel ULiege; Laloyaux, Olivier ULiege; Mardaga, Solange et al

in Biological Psychology (2004), 67(3), 331-41

Contradictory findings exist concerning the inhibitory function of low frequency repetitive transcranial magnetic stimulation (rTMS). Therefore, the study examines the impact of different duration of low ... [more ▼]

Contradictory findings exist concerning the inhibitory function of low frequency repetitive transcranial magnetic stimulation (rTMS). Therefore, the study examines the impact of different duration of low frequency rTMS on ERPs. In 17 subjects, auditory ERPs were measured before and after 1 Hz rTMS delivered over the left prefrontal cortex during 10 min (600 pulses) and 15 min (900 pulses). Results showed that 15 min of 1 Hz rTMS induced a significant increase of P300 latency. There was no effect for early ERP components (N100, P200 and N200). This study confirms and extends that 1 Hz rTMS produces a real inhibitory effect only when the duration of the stimulation is about 15 min. The data suggest that rTMS modifies the speed of cognitive processing rather than the energetical aspect of information processing, and that cortical inhibition induced by the magnetic stimulation affects principally the controlled cognitive processes and not the automatic ones. [less ▲]

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See detailFinite element modelling of stacked thin regions with non-zero global currents
Dular, Patrick ULiege; Gyselinck, Johan; Zeidan, Tarek et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2004), 23(3), 707-714

Develops a method to take the eddy currents in stacked thin regions, in particular lamination stacks, into account with the finite element method using the 3D magnetic vector potential magnetodynamic ... [more ▼]

Develops a method to take the eddy currents in stacked thin regions, in particular lamination stacks, into account with the finite element method using the 3D magnetic vector potential magnetodynamic formulation. It consists in converting the stacked laminations into continuums with which terms are associated for considering the eddy current loops produced by both parallel and perpendicular fluxes. Non-zero global currents can be considered in the laminations, in particular for studying the effect of imperfect insulation between their ends. The method is based on an analytical expression of eddy currents and is adapted to a wide frequency range. [less ▲]

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See detailReceptor-based screening assays: New perspectives in anti-doping control
Scippo, Marie-Louise ULiege; Willemsen, Philippe; Danyi, Sophie ULiege et al

in Chromatographia (2004), 59(Suppl. S), 23-27

The so-called "growth promoters", steroid hormones and beta-agonists, are currently controlled by using hyphenated analytical methods (chromatography coupled to mass spectrometry) or, sometimes for ... [more ▼]

The so-called "growth promoters", steroid hormones and beta-agonists, are currently controlled by using hyphenated analytical methods (chromatography coupled to mass spectrometry) or, sometimes for screening purposes, on immunoassays. These methods are often too specific to allow an effective multianalyte control. To develop more efficient assays, the use of hormonal receptors as detection tools (receptor-based binding assays and cell-based assays) is proposed. Receptor-based assays represent useful tools in screening of hormonal residues in food, but they could also be applied in doping control (to detect "new" hormonal substances). Furthermore, these assays could be used to monitor the human exposure to endocrine disruptors. [less ▲]

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See detailHospital outbreak of gastroenteritis due to norovirus in Belgium
Verbelen, V.; Bodeus, Monique; Garrino, M. G. et al

in Acta Clinica Belgica (2004), 59(1, JAN-FEB), 30-33

We report an outbreak of gastroenteritis due to Norovirus in a care unit in a Belgian hospital involving thirty-three people. The origin of the outbreak was traced to one nursing assistant. The virus ... [more ▼]

We report an outbreak of gastroenteritis due to Norovirus in a care unit in a Belgian hospital involving thirty-three people. The origin of the outbreak was traced to one nursing assistant. The virus strain identified by reverse transcription polymerase chain reaction and electron microscopy belonged to the genogroup II. [less ▲]

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See detailRecovery from Neuromuscular Block after an Intubation Dose of Cisatracurium and Rocuronium in Lumbar Disc Surgery
Hans, Pol ULiege; Welter, Philippe ULiege; Dewandre, Pierre-Yves et al

in Acta Anaesthesiologica Belgica (2004), 55(2), 129-33

BACKGROUND AND OBJECTIVE: Residual muscle paralysis remains a concern for anaesthesiologists. This study investigated the recovery from neuromuscular block (NMB) after an intubation dose of cisatracurium ... [more ▼]

BACKGROUND AND OBJECTIVE: Residual muscle paralysis remains a concern for anaesthesiologists. This study investigated the recovery from neuromuscular block (NMB) after an intubation dose of cisatracurium (C) or rocuronium (R) in 32 patients undergoing lumbar disc surgery. METHODS: Anaesthesia was induced with propofol and sufentanil, and maintained with sevoflurane in nitrous oxide/oxygen. Patients were randomised to receive twice the ED95 of either cisatracurium (GC) or rocuronium (GR) before tracheal intubation. After placement in prone position, neuromuscular transmission was monitored at the wrist by accelerometry. NMB was antagonised when the TOF ratio (TOFR) was < 0.75 at muscle closure. The time from muscle relaxant to muscle closure, and to TOFR of 0.25 and of 0.50 were recorded. Data were analysed using Student's t-tests, chi-squared tests and two-way mixed-designed ANOVA's. The prediction probability (Pk) of the times from muscle relaxant to muscle closure, and to TOFR of 0.25 for the necessity to antagonize NMB was calculated in both groups. P < 0.05 was considered statistically significant. RESULTS: NMB was antagonized in 8 (GC) and 6 (GR) patients, respectively. The time from muscle relaxant to muscle closure was shorter in patients whose NMB was antagonized. The Pk of this time was significant in GC (0.85) but not in GR (0.69). In GR contrarily to GC, the times to a TOFR of 0.25 and 0.50 were longer in patients whose NMB was antagonized. The Pk of the time to TOFR of 0.25 was significant in GR (0.95) but not in GC (0.64). CONCLUSIONS: A single dose of cisatracurium or rocuronium may be associated to some degree of NMB at the end of lumbar surgery, depending on the duration of surgery and on the duration of action of the muscle relaxant which is more variable for rocuronium than for cisatracurium. [less ▲]

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See detailEtching techniques for realizing optical micro-cavity atom traps on silicon
Moktadir, Zakaria; Koukharenka, Elena; Kraft, Michaël ULiege et al

in Journal of Micromechanics and Microengineering (2004), 14(9), 82-85

We have fabricated curved optical micromirrors on silicon. We expect to be able to form open optical cavities between these mirrors and plane mirrors coated on the ends of optical fibres. The curved mirror ... [more ▼]

We have fabricated curved optical micromirrors on silicon. We expect to be able to form open optical cavities between these mirrors and plane mirrors coated on the ends of optical fibres. The curved mirror templates have been prepared with less than 10 nm surface roughness by means of isotropic chemical etching. Two different methods are used for the fabrication of the mirrors: the first method uses a silicon oxide mask, while the second uses dry etching to form an indentation in the silicon surface that is opened out by wet isotropic etching. After coating the silicon substrate with gold, good quality mirrors are obtained with R ∼ 98% in the near infra-red. We find that a reflectivity of approximately 98% can be achieved by this method. Cavities formed from these mirrors will be useful for manipulating single atoms. [less ▲]

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See detail« Myosite » focale de la loge antéro-externe de la jambe : à propos d’un cas
TOMASELLA, Marco ULiege; CRIELAARD, Jean-Michel ULiege; WANG, François-Charles ULiege

in Neurophysiologie Clinique = Clinical Neurophysiology (2004)

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See detailCette île est mienne... et tu me l'as prise: Shakespeare au XXe siècle
Maes-Jelinek, Hena ULiege

in Bulletin de la Classe des Lettres et des Sciences Morales et Politiques (2004), 15(1-6), 23-41

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See detailAnalysis of experimental conditions for simultaneous measurements of transport and magnetotransport coefficients of high temperature superconductors
Mucha, J.; Dorbolo, Stéphane ULiege; Bougrine, Hassan ULiege et al

in Cryogenics (2004), 44(3), 145-149

Experimental conditions for simultaneous measurements of transport coefficients of high temperature superconductors in zero and non-zero magnetic fields are analysed. Test measurements of the thermal ... [more ▼]

Experimental conditions for simultaneous measurements of transport coefficients of high temperature superconductors in zero and non-zero magnetic fields are analysed. Test measurements of the thermal conductivity, the thermoelectric power and the Nernst-Ettingshausen effect of a textured Bi2212 sample are reported in an external magnetic field of 2 T. Errors related to parameters of the thermocouple used and to the spurious heat flows are discussed for a new experimental set-up built based on a closed cycle helium refrigerator. Possible optimising of experimental conditions is suggested. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailLiquid-liquid phase separation in gravity settler with inclined plates
Schlieper, L; Chatterjee, M; Henschke, Martin et al

in AIChE Journal (2004), 50(4), 802-811

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See detailProtective effect of EGB 761 against oxidative phosphorylation damages of brain mitochondria after Anoxia/reoxygenation in vivo and in vitro
Du, G.; Willet, K.; Jarmuszkiewicz, W. et al

in Toxicology Mechanisms & Methods (2004), 14

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See detailRedox state of endogenous coenzyme q modulates the inhibition of linoleic acid-induced uncoupling by guanosine triphosphate in isolated skeletal muscle mitochondria.
Jarmuszkiewicz, W.; Navet, R.; Alberici, L. et al

in Journal of Bioenergetics & Biomembranes (2004), 36

The skeletal muscle mitochondria contain two isoforms of uncoupling protein, UCP2 and mainly UCP3, which had been shown to be activated by free fatty acids and inhibited by purine nucleotides in ... [more ▼]

The skeletal muscle mitochondria contain two isoforms of uncoupling protein, UCP2 and mainly UCP3, which had been shown to be activated by free fatty acids and inhibited by purine nucleotides in reconstituted systems. On the contrary in isolated mitochondria, the protonophoretic action of muscle UCPs had failed to be demonstrated in the absence of superoxide production. We showed here for the first time that muscle UCPs were activated in state 3 respiration by linoleic acid and dissipated energy from oxidative phosphorylation by decreasing the ADP/O ratio. The efficiency of UCPs in mitochondrial uncoupling increased when the state 3 respiratory rate decreased. The inhibition of the linoleic acid-induced uncoupling by a purine nucleotide (GTP), was not observed in state 4 respiration, in uninhibited state 3 respiration, as well as in state 3 respiration inhibited by complex III inhibitors. On the contrary, the progressive inhibition of state 3 respiration by n -butyl malonate, which inhibits the uptake of succinate, led to a full inhibitory effect of GTP. Therefore, as the inhibitory effect of GTP was observed only when the reduced state of coenzyme Q was decreased, we propose that the coenzyme Q redox state could be a metabolic sensor that modulates the purine nucleotide inhibition of FFA-activated UCPs in muscle mitochondria. [less ▲]

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See detailComment je traite...un psoriasis du cuir chevelu.
Uhoda, I.; Flagothier, Caroline ULiege; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2004), 59(9), 481-4

Scalp involvement by psoriasis requires a ted treatment suited to the particularities of the anatomical site In course of time, the improvement of therapeutic agents and the galenic refinement have ... [more ▼]

Scalp involvement by psoriasis requires a ted treatment suited to the particularities of the anatomical site In course of time, the improvement of therapeutic agents and the galenic refinement have enhanced both the efficacy and cosmetic acceptability of the scalp care. The main therapeutic classes encompass keratolytics, dermocorticosteroids and vitamine D3 analogues. The patient compliance is reported to be best for the liquid or foam formulations. [less ▲]

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See detailEtude de l'entérotoxémie bovine en Belgique. III. Comparaison de différents protocoles d'immunisation contre la toxine alpha de Clostridium perfringens
Manteca, Christophe; Ginter, Annita; Limbourg, Bernard et al

in Annales de Médecine Vétérinaire (2004), 148(3), 147-152

Previous surveys demonstrated the association between the bovine enterotoxaemia syndrome and proliferation of Clostridium perfringens toxintype A. The purpose of this study was to establish rules for ... [more ▼]

Previous surveys demonstrated the association between the bovine enterotoxaemia syndrome and proliferation of Clostridium perfringens toxintype A. The purpose of this study was to establish rules for vaccination of calves against the a toxin. Bovines were Belgian Blue (BBB) or BBB x Charolais originating from 6 farms with no history of clostridial vaccination. One hundred and thirty-three calves were injected with Tasvax (R) and 70 with Miloxan (R) at one and two months of age, while 94 calves received no vaccine. To study sero-conversion in calves born from vaccinated dams, 67 cows were vaccinated with Tasvax at 7 and 8 months pregnancy. Twenty-nine calves born from these cows were vaccinated at one and two months of age with the same vaccine while 38 calves were not vaccinated. The results of these 67 calves were also compared to the results obtained from the calves born from non-vaccinated cows and vaccinated with Tasvax. Anti-alpha toxin antibodies were measured using an indirect ELISA assay. Anti-alpha toxin antibodies are naturally present in the serums of non vaccinated animals and are transferred to the newborn calf by the colostrum. The two vaccinal injections cause sero-conversions in proportion of the total amount of immunogen received. The best protocol for calf vaccination is a first injection at one month of age, followed by a booster injection four weeks later. Boosters every six months are necessary to maintain a high level of antibody. In case of early problems (< 2 months of age) of enterotoxaemia in a farm, high antibody titres are obtained only following the vaccination of the pregnant cow and colostral transfer. Unfortunately this protocol is not compatible with vaccination of the calf itself. [less ▲]

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See detailPoly(A) RNA is reduced by half during bovine oocyte maturation but increases when meiotic arrest is maintained with CDK inhibitors.
Lequarré, Anne-Sophie ULiege; Traverso, Juan M; Marchandise, Joelle et al

in Biology of Reproduction (2004), 71(2), 425-31

Variations in the amount of different RNA species were investigated during in vitro maturation of bovine oocytes. Total RNA content was estimated to be 2 ng before meiosis, and after meiosis resumption ... [more ▼]

Variations in the amount of different RNA species were investigated during in vitro maturation of bovine oocytes. Total RNA content was estimated to be 2 ng before meiosis, and after meiosis resumption, no decrease was observed. Ribosomal RNA did not appear to be degraded either, whereas poly(A) RNA was reduced by half after meiosis resumption, from 53 pg to 25 pg per oocyte. Real-time polymerase chain reaction was performed on growth and differentiation factor-9 (GDF-9), on cyclin B1, and on two genes implicated in the resistance to oxidative stress, glucose-6-phosphate-dehydrogenase (G6PD) and peroxiredoxin-6 (PRDX6). When these transcripts were reverse-transcribed with hexamers, the amplification results were not different before or after in vitro maturation. But when reverse transcription was performed with oligo(dT), amplification was dramatically reduced after maturation, except for cyclin B1 mRNA, implying deadenylation without degradation of three transcripts. Although calf oocytes have a lower developmental competence, their poly(A) RNA contents were not different from that of cow oocytes, nor were they differently affected during maturation. When bovine oocytes were maintained in vitro under meiotic arrest with CDK inhibitors, their poly(A) RNA amount increased, but this rise did not change the poly(A) RNA level once maturation was achieved. The increase could not be observed under transcription inhibition and, when impeding transcription and adenylation, the poly(A) RNA decreased to a level normally observed after maturation, in spite of the maintenance of meiotic arrest. These results demonstrate the importance of adenylation and deadenylation processes during in vitro maturation of bovine oocytes. [less ▲]

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See detailLumped low-order time-domain model of eddy current effects in laminated cores
Gyselinck, Johan; Dular, Patrick ULiege

in International Journal of Applied Electromagnetics and Mechanics (2004), 19(1-avr Sp. Iss. SI), 281-285

The authors present a novel lumped model for laminated cores considering the ID eddy current problem in a conducting ferromagnetic lamination. The model is based on a polynomial spatial expansion of the ... [more ▼]

The authors present a novel lumped model for laminated cores considering the ID eddy current problem in a conducting ferromagnetic lamination. The model is based on a polynomial spatial expansion of the induction and the magnetic field throughout the thickness of the lamination, of order n and n + 2 respectively, such that the governing partial differential equation is satisfied (for any n greater than or equal to 0). The magnetic constitutive law is weakly imposed, leading to a system of 1 + n/2 nonlinear differential equations. The method is elaborated and validated for both the linear and the nonlinear case. A fast convergence towards the exact solution (n = infinity) is observed when increasing n. [less ▲]

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See detailResponse to novelty as a predictor for drug effects: the pitfalls of some correlational studies
Quertemont, Etienne ULiege; Brabant, Christian ULiege; Tirelli, Ezio ULiege

in Psychopharmacology (2004), 173(1-2), 221-224

In recent years, an individual's response to novelty has been postulated to predict its response to drugs of abuse and particularly to their addictive properties (Piazza et al. 1990). The hypothesis of a ... [more ▼]

In recent years, an individual's response to novelty has been postulated to predict its response to drugs of abuse and particularly to their addictive properties (Piazza et al. 1990). The hypothesis of a relationship between the response to novelty and the effects of addictive drugs was supported by a number of animal studies that reported correlations between responses to a novel environment and various effects of drugs, such as their locomotor stimulant effects, their reinforcing action or their propensity to be self-administered (Piazza et al. 1990; Klebaur et al. 2001; Carey et al. 2003; Shimosato and Watanabe 2003). Most of these studies concluded that an animal's response to novelty predicts its subsequent response to drug administration. However, correlational studies are sometimes hampered by methodological and statistical weaknesses that preclude a proper interpretation of the results. The two most frequent weaknesses are the lack of consideration for the correlation in the control group and the calculation of spurious correlations. [less ▲]

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See detailElectrical machine analysis considering field-circuit-movement and skewing effects
de Oliveira, Ana Margarida; Antunes, R.; Kuo-Peng, Patrick et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2004), 23(4), 1080-1091

This paper presents a method to analyse electrical machines considering simultaneously the electromagnetic field, electric circuit, control loop, movement and skewing effects. The major contribution of ... [more ▼]

This paper presents a method to analyse electrical machines considering simultaneously the electromagnetic field, electric circuit, control loop, movement and skewing effects. The major contribution of this work leans on its generality, i.e. it can be applied to electrical machines connected to static converters submitted to any control laws, avoiding an a priori analysis. Simulation results of a three-phase Brushless AC (BLAC) motor fed by a PWM converter is presented as well as a comparison of simulation and experimental results obtained using a two-phase-on converter were also presented. [less ▲]

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See detailRole of lipopeptides produced by Bacillus subtilis GA1 in the reduction of grey mould disease caused by Botrytis cinerea on apple
Toure, Y.; Ongena, MARC ULiege; Jacques, Philippe ULiege et al

in Journal of Applied Microbiology (2004), 96(5), 1151-1160

AIM: Test of Bacillus subtilis strain GA1 for its potential to control grey mould disease of apple caused by Botrytis cinerea. METHODS AND RESULTS: GA1 was first tested for its ability to antagonize in ... [more ▼]

AIM: Test of Bacillus subtilis strain GA1 for its potential to control grey mould disease of apple caused by Botrytis cinerea. METHODS AND RESULTS: GA1 was first tested for its ability to antagonize in vitro the growth of a wide variety of plant pathogenic fungi responsible for diseases of economical importance. The potential of strain GA1 to reduce post-harvest infection caused by B. cinerea was tested on apples by treating artificially wounded fruits with endospore suspensions. Strain GA1 was very effective at reducing disease incidence during the first 5 days following pathogen inoculation and a 80% protection level was maintained over the next 10 days. Treatment of fruits with an extract of GA1 culture supernatant also exerted a strong preventive effect on the development of grey mould. Further analysis of this extract revealed that strain GA1 produces a wide variety of antifungal lipopeptide isomers from the iturin, fengycin and surfactin families. A strong evidence for the involvement of such compounds in disease reduction arose from the recovery of fengycins from protected fruit sites colonized by bacterial cells. CONCLUSIONS: The results presented here demonstrate that, despite unfavourable pH, B. subtilis endospores inoculated on apple pulp can readily germinate allowing significant cell populations to establish and efficient in vivo synthesis of lipopeptides which could be related to grey mould reduction. SIGNIFICANCE AND IMPACT OF THE STUDY: This work enables for the first time to correlate the strong protective effect of a particular B. subtilis strain against grey mould with in situ production of fengycins in infected sites of apple fruits. [less ▲]

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See detailRisk evaluation of the transmission of the avian influenza virus to humans
Saegerman, Claude ULiege; Meulemans, G.; Van Reeth, K. et al

in Annales de Médecine Vétérinaire (2004), 148(2), 65-77

Since mid-december 2003, an epizootic of highly pathogenic avian influenza (type A, sub-type H5N1) occurs in eastern and south-eastern Asia. This epizootic is historically unprecedented in its virulence ... [more ▼]

Since mid-december 2003, an epizootic of highly pathogenic avian influenza (type A, sub-type H5N1) occurs in eastern and south-eastern Asia. This epizootic is historically unprecedented in its virulence, geographical spread, and economic consequences for the agricultural sector. Implications for human health were registered in Vietnam and in Thailand. This paper summarizes the current knowledge about the risk evaluation of the transmission of avian influenza virus to humans. The current asian epizootic has highlighted the key role of global health information systems and also the need for exhaustive notification of human and animal cases. It reinforces the concept of veterinary public health. [less ▲]

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See detailCardiac tamponade and pulmonary compression due to volvulus of oesophageal coloplasty
Canivet, Jean-Luc ULiege; Piret, Sonia ULiege; Hick, Gaëtane ULiege et al

in Acta Anaesthesiologica Belgica (2004), 55(2), 125-127

We describe an unusual case of cardiac tamponade and pulmonary compression due to acute volvulus of colon interposition occuring late after oesophagectomy. Clinical signs were suggestive of cardiac ... [more ▼]

We describe an unusual case of cardiac tamponade and pulmonary compression due to acute volvulus of colon interposition occuring late after oesophagectomy. Clinical signs were suggestive of cardiac tamponade but there was no evidence of pericardial effusion by transthoracic echocardiography. Thoracic-CT provided the diagnostic clue in revealing the extrapericardial nature (a major dilatation of the colonic transplant) of the tamponade. This diagnosis should be considered in case of acute cardiopulmonary distress occuring early or late after oesophagectomy. [less ▲]

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See detailScreening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class IHDAC profiles between epithelial and stromal cells
Waltregny, David ULiege; North, Brian; Van Mellaert, Frank et al

in European Journal of Histochemistry (2004), 48(3, Jul-Sep), 273-290

Histone deacetylases (HDACs) represent a large family of enzymes identified as key regulators of nucleosomal histone acetylation, a major epigenetic event that controls eukaryotic gene transcription ... [more ▼]

Histone deacetylases (HDACs) represent a large family of enzymes identified as key regulators of nucleosomal histone acetylation, a major epigenetic event that controls eukaryotic gene transcription. Inappropriate deacetylation mediated by HDACs has been associated with profound alterations in cellular biology. We have thus hypothesized that an altered HDAC expression may favor cancer development/progression. To test this possibility, we have sought to screen the expression profiles of several class I and class 11 HDACs (HDAC1-8) in DU-145, PC-3 and LNCaP human prostate cancer cell lines as well as in matched malignant and nonmalignant prostate tissues by use of real time RT-PCR, immunoblot and immunohistochemistry. All HDAC transcripts tested were detected at various levels in all prostate cancer cell lines and tissue samples analyzed. In prostate tissues, the abundance of HDAC1 protein, which was exclusively expressed in the cell nucleus, was similar in normal and malignant epithelial cells, but was usually lower in stromal cells. Unexpectedly, HDAC8, another class I HDAC, was not detected in epithelial cells but was uniquely expressed in the cytoplasm of stromal cells, HDAC5, a class II HDAC involved in myogenesis, was not detected in the tissues. Altogether, our findings indicate that epithelial and stromal cells exhibit distinct class I HDAC expression profiles, and the abundance of HDAC1 is not altered in human prostate cancer. In addition, our observations are the first to demonstrate the prominently cytosolic distribution of a class I HDAC, HDAC8. [less ▲]

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See detailEntreprendre au féminin : une réalité multiple et des attentes différenciées
Cornet, Annie ULiege; Constantinidis, Christina ULiege

in Revue Française de Gestion (2004), 30(151), 191-204

Les femmes optent de plus en plus souvent pour le statut d’indépendante et, trop rarement encore, pour le statut de « chef d’entreprise ». Cet article cherche à comprendre les facteurs qui semblent guider ... [more ▼]

Les femmes optent de plus en plus souvent pour le statut d’indépendante et, trop rarement encore, pour le statut de « chef d’entreprise ». Cet article cherche à comprendre les facteurs qui semblent guider leur choix, le type d’activités vers lesquelles elles s’orientent, les difficultés qu’elles rencontrent ainsi que leurs succès et les stratégies mises en œuvre pour réussir leur projet. Cet article est fondé sur une recherche quantitative et qualitative qui permet de montrer que le projet entrepreneurial des femmes a certes des similarités avec celui des hommes mais certains choix et stratégies restent marqués par des rapports sociaux de genre. [less ▲]

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See detailComment j'explore... une perte de cheveux chez un patient cancéreux.
Pierard, Claudine ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2004), 59(9), 525-9

Increased hair loss followed, in some instances by an acute focal or total alopecia, can develop in some cancer patients. The surgical stress or procedure, radiotherapy and some chemotherapy regimens can ... [more ▼]

Increased hair loss followed, in some instances by an acute focal or total alopecia, can develop in some cancer patients. The surgical stress or procedure, radiotherapy and some chemotherapy regimens can be responsible for these disturbing events. The alopecia is transient or permanent according to its origin. Diverse diagnostic and prognostic methods are available for assessing alopecias. The trichogram is a rewarding one. [less ▲]

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See detailUltralow silicon substrate noise crosstalk using metal Faraday cages in an SOI technology
Stefanou, Stefanos; Hamel, John Stan; Baine, Paul et al

in IEEE Transactions on Electron Devices (2004), 51(3), 486--491

Ultralow substrate crosstalk is demonstrated using a novel metal Faraday cage isolation scheme in silicon-on-insulator technology. Over ten times reduction in crosstalk is demonstrated up to 10 GHz ... [more ▼]

Ultralow substrate crosstalk is demonstrated using a novel metal Faraday cage isolation scheme in silicon-on-insulator technology. Over ten times reduction in crosstalk is demonstrated up to 10 GHz, compared to previously reported substrate crosstalk suppression technologies. [less ▲]

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See detailInterassay and interobserver variability in the detection of anti-neutrophil cytoplasmic antibodies in patients with ulcerative colitis.
Joossens, Sofie; Daperno, Marco; Shums, Zakera et al

in Clinical Chemistry (2004), 50(8), 1422-5

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See detailComplementary two-dimensional finite element formulations with inclusion of a vectorized Jiles-Atherton model
Gyselinck, Johan; Vandevelde, Lieven; Melkebeek, Jan et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (2004), 23(4), 959-967

This paper deals with the magnetic vector and scalar potential formulation for two-dimensional (2D)finite element (FE) calculations including a vector hysteresis model, namely a vectorized Jiles-Atherton ... [more ▼]

This paper deals with the magnetic vector and scalar potential formulation for two-dimensional (2D)finite element (FE) calculations including a vector hysteresis model, namely a vectorized Jiles-Atherton model. The particular case of a current-free FE model with imposed fluxes and magnetomotive forces is studied. The non-linear equations are solved by means of the Newton-Raphson method, which leads to the use of the differential reluctivity and permeability tensor. The proposed method is applied to a simple 2D model exhibiting rotational flux, viz the T-joint of a three-phase transformer. [less ▲]

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See detailTransmission of CARD15 (NOD2) variants within families of patients with inflammatory bowel disease.
Esters, Nele; Pierik, Marie; Van Steen, Kristel ULiege et al

in American Journal of Gastroenterology (2004), 99(2), 299-305

OBJECTIVES: Three single nucleotide polymorphisms (SNPs) in CARD15 have been independently associated with Crohn's disease (CD). Since nothing is known about the transmission of these variants within ... [more ▼]

OBJECTIVES: Three single nucleotide polymorphisms (SNPs) in CARD15 have been independently associated with Crohn's disease (CD). Since nothing is known about the transmission of these variants within families, this was the subject of our study in Flemish patients with inflammatory bowel disease (IBD) and their healthy relatives. METHODS: A cohort of 1,670 individuals (570 CD, 173 UC, 165 healthy controls, 762 first-degree unaffected relatives of CD patients) was genotyped for Arg702Trp, Gly908Arg, and Leu1007fsinsC. Mutant allele and carrier frequencies were compared between groups. Segregation patterns were compared using a bivariate Dale model. RESULTS: The carrier prevalence of CARD15 variants for CD patients was 46.3%, compared to 20.6% for healthy controls and 22.0% for ulcerative colitis (UC) patients (both p < 0.0001). An increased carriage rate of CARD15 variants was observed in unaffected relatives of CD patients (37.3%; p < 0.0001 vs controls), although this was significantly lower than in the CD patients (p = 0.001). Paternal transmission gave a 5.17-fold higher chance for the child to develop the disease compared to maternal transmission (95% CI [1.59, 16.78]; p = 0.0063). UC patients belonging to mixed IBD families carried significantly more mutations (42.3%) compared to other UC patients (18.4%) (p < 0.01). CONCLUSIONS: Maternal transmission of the CARD15 variant allele is associated with a lower proportion of affected individuals compared to paternal transmission. Therefore, maternal transmission does not carry an increased risk of transmission as does paternal transmission. The increased mutation carriage in unaffected siblings of CD patients and in UC patients belonging to mixed families suggests that other factors than CARD15 contribute to the eventual disease expression. [less ▲]

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See detailDu quota d'émission de gaz à effet de serre
Pâques, Michel ULiege; Charneux, S.

in Revue européenne de droit de l'environnement (2004), 3

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See detailLe cas clinique du mois. Fasciolase cutanée.
Garcia Moreno Rodriguez, Renata ULiege; Arrese Estrada, Jorge ULiege; Ugarte, G. et al

in Revue Médicale de Liège (2004), 59(10), 552-4

Fascioliasis is an hepato-biliary distomatosis which may exceptionally manifest itself in the skin. We report a case presenting as nodules localized on the trunk. Lesions cleared under praziquantel ... [more ▼]

Fascioliasis is an hepato-biliary distomatosis which may exceptionally manifest itself in the skin. We report a case presenting as nodules localized on the trunk. Lesions cleared under praziquantel treatment. [less ▲]

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See detailActualité du permis d'environnement, du permis unique et un mot du CWATUP
Pâques, Michel ULiege

in Actualité législative en droit immobilier (2004)

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See detailDeficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis
Franchimont, D.; Vermeire, S.; El Housni, H. et al

in Gut (2004), 53(7), 987-992

Background and aims: Elicitation of an innate immune response to bacterial products is mediated through pattern recognition receptors (PRRs) such as the toll-like receptors (TLRs) and the NODs. The ... [more ▼]

Background and aims: Elicitation of an innate immune response to bacterial products is mediated through pattern recognition receptors (PRRs) such as the toll-like receptors (TLRs) and the NODs. The recently characterised Asp299Gly polymorphism in the lipopolysaccharide (LPS) receptor TLR4 is associated with impaired LPS signalling and increased susceptibility to Gram negative infections. We sought to determine whether this polymorphism was associated with Crohn's disease ( CD) and/or ulcerative colitis (UC). Methods: Allele frequencies of the TLR4 Asp299Gly polymorphism and the three NOD2/CARD15 polymorphisms (Arg702Trp, Gly908Arg, and Leu1007fsinsC) were assessed in two independent cohorts of CD patients ( cohort 1, n = 334; cohort 2, n = 114), in 163 UC patients, and in 140 controls. A transmission disequilibrium test (TDT) was then performed on 318 inflammatory bowel disease (IBD) trios. Results: The allele frequency of the TLR4 Asp299Gly polymorphism was significantly higher in CD ( cohort 1: 11% v 5%, odds ratio ( OR) 2.31 (95% confidence interval (CI) 1.28 - 4.17), p = 0.004; and cohort 2: 12% v 5%, OR 2.45 ( 95% CI 1.24 - 4.81), p = 0.007) and UC patients (10% v 5%, OR 2.05 ( 95% CI 1.07 3.93), p = 0.027) compared with the control population. A TDT on 318 IBD trios demonstrated preferential transmission of the TLR4 Asp299Gly polymorphism from heterozygous parents to affected children (T/U: 68/34, p = 0.01). Carrying polymorphisms in both TLR4 and NOD2 was associated with a genotype relative risk (RR) of 4.7 compared with a RR of 2.6 and 2.5 for TLR4 and NOD2 variants separately. Conclusion: We have reported on a novel association of the TLR4 Asp299Gly polymorphism with both CD and UC. This finding further supports the genetic influence of PRRs in triggering IBD. [less ▲]

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See detailMagnitude comparison in preschoolers: what counts ? Influence of perceptual variables.
Rousselle, Laurence ULiege; Palmers, Emmanuelle; Noël, Marie-Pascale

in Journal of Experimental Child Psychology (2004), 87

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See detailGlycosyltransferases encoded by viruses.
Markine-Goriaynoff, Nicolas; Gillet, Laurent ULiege; Van Etten, James L et al

in Journal of General Virology (The) (2004), 85(Pt 10), 2741-54

Studies of cellular biology in recent decades have highlighted the crucial roles of glycans in numerous important biological processes, raising the concept of glycomics that is now considered as important ... [more ▼]

Studies of cellular biology in recent decades have highlighted the crucial roles of glycans in numerous important biological processes, raising the concept of glycomics that is now considered as important as genomics, transcriptomics and proteomics. For millions of years, viruses have been co-evolving with their hosts. Consequently, during this co-evolution process, viruses have acquired mechanisms to mimic, hijack or sabotage host processes that favour their replication, including mechanisms to modify the glycome. The importance of the glycome in the regulation of host-virus interactions has recently led to a new concept called 'glycovirology'. One fascinating aspect of glycovirology is the study of how viruses affect the glycome. Viruses reach that goal either by regulating expression of host glycosyltransferases or by expressing their own glycosyltransferases. This review describes all virally encoded glycosyltransferases and discusses their established or putative functions. The description of these enzymes illustrates several intriguing aspects of virology and provides further support for the importance of glycomics in biological processes. [less ▲]

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See detailComparative titration of ginsenosides by different techniques in commercial ginseng products and callus cultures
Kevers, Claire ULiege; Jacques, Philippe ULiege; Gaspar, Thomas ULiege et al

in Journal of Chromatographic Science (2004), 42(10, Nov-Dec), 554-558

The ginsenoside content of different ginseng species (Panax ginseng, P. quinquefolium, and P. vietnamensis) from different sources (roots from field-grown plants or from in vitro cultures, cells from ... [more ▼]

The ginsenoside content of different ginseng species (Panax ginseng, P. quinquefolium, and P. vietnamensis) from different sources (roots from field-grown plants or from in vitro cultures, cells from solid calluses or from liquid cultures, commercial powders, and suspensions) is evaluated by means of a new high-performance thin-layer chromatography (HPTLC) technique combining an automatic TLC sampler and scanner. The results are compared with those obtained through more classical gross spectrometric and high-performance liquid chromatography (HPLC) techniques. HPTLC and HPLC allow the separation and estimation of the different ginsenosides. For this, HPTLC is faster and simpler than HPLC. Both techniques determine less amounts of ginsenosides than spectrophotometry, which displays overestimated values caused by light absorption by contaminating osides. In vitro cultured cells and roots contain the same ginsenosides as those produced by their mother plants, although at quite lower levels. The culture media also accumulates ginsenosides. [less ▲]

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See detailWhole body barometric plethysmography: a screening method to investigate airway reactivity and acute lung injuries in freely moving pigs
Halloy, D.; Kirschvink, Nathalie; Vincke, G. et al

in Veterinary Journal (2004), 168

The aim of this work was to investigate whether the Penh index, measured using whoie body barometric piethysmography, can be used as a screening parameter to evaluate the airway reactivity and the ... [more ▼]

The aim of this work was to investigate whether the Penh index, measured using whoie body barometric piethysmography, can be used as a screening parameter to evaluate the airway reactivity and the intensity of the pulmonary response to endotoxins. Penh was firstly recorded in non-sedated freeiy moving piglets exposed (1) to a nebulized acetylchoiine (Ach) pre-treated or not with cienbuterol, or (2) to endotoxin challenge. To measure Penh simultaneously with total pulmonary resistance (RL), dynamic compliance (cd1) and intrapleural pressure changes (MaxPpl), an oesophageal balloon catheter technique was used and the piglets were anaesthetised. The recordings were performed during (1) an intravenous metacholine (Mch) challenge and (2) in endotoxin-exposed animais. In freely moving animais, Ach induced a significant dose-dependent increase in Penh, which was significantly blocked by clenbuterol. Endotoxin instillation aiso resulted in a significant rise in Penh while the corresponding response measured under anaesthesia was signiflcantly and positively correlated with RL and MaxzPpi. Similar results were obtained during Mch challenge but the Penh was negatively correlated with Cd. We conclude that Penh could be used in freely moving piglets as a screening index for airway reactivity and pulmonary functional changes in cholinergic and endotoxin challenges [less ▲]

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See detailINFECTIONS ET PROPHYLAXIES ANTIINFECTIEUSES DANS LA DRÉPANOCYTOSE
Lepage, P; DRESSE, Marie-Françoise ULiege; FORGET, Patricia ULiege et al

in Revue Médicale de Liège (2004), 59(3), 145-148

Bacterial infections remain a major cause of morbidity and mortality among young children with sickle cell susceptibility to infections is mainly observed in homozygous sickle cell disease. The incidence ... [more ▼]

Bacterial infections remain a major cause of morbidity and mortality among young children with sickle cell susceptibility to infections is mainly observed in homozygous sickle cell disease. The incidence of bacteremias in children under 3 years of age is ~8 events/100 patient-years among homozygous subjects and ~5 events/100 patient-years among those with SC hemoglobinopathy. Pneumococci and Salmonellae are the most frequently isolated bacteria. Severe clinical manifestations include septicemia, meningitis, osteomyelitis and pneumonia. M. Pneumoniae and C. Pneumoniae infections may be severe and may induce acute chest syndrome. The high incidence and severity of bacterial infections in these children justify prevention efforts by antibiotic prophylaxis and vaccination. The efficacy of oral penicillin prophylaxis against pneumococcal infections has been well demonstrated and is now recommended from 3 months of age. The antipneumococcal conjugate vaccine has been shown to be safe and immunogenic in young infants. [less ▲]

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See detailA family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects
Lange, C.; Van Steen, Kristel ULiege; Andrew, T. et al

in Statistical Applications in Genetics and Molecular Biology (2004), 3(1), 17

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See detailMicrofabrication of gold wires for atom guides
Koukharenko, Elena; Moktadir, Zakaria; Kraft, Michaël ULiege et al

in Sensors and Actuators A (2004), 115(2-3), 600--607

Miniaturised atom optics is a new field allowing the control of cold atoms in microscopic magnetic traps and waveguides. Using microstructures (hereafter referred to as atom chips), the control of cold ... [more ▼]

Miniaturised atom optics is a new field allowing the control of cold atoms in microscopic magnetic traps and waveguides. Using microstructures (hereafter referred to as atom chips), the control of cold atoms on the micrometer scale becomes possible. Applications range from integrated atom interferometers to the realisation of quantum gates. The implementation of such structures requires high magnetic field gradients. The motivation of this work was to develop a suitable fabrication process for micromachined high-density current-carrying wires for atom guides. However, the developed process may be used for a variety of applications such as on-chip inductors and microtransformers. In order to realise the micromachined wires for atom guides different designs and fabrication processes were investigated. We discuss the feasibility and the suitability of the fabrication process based on gold sputtering technique to realise such devices. As an alternative we have considered a lower cost technique based on gold electroplating. For the electroplating we used commercial full bright cyanide free gold plating solution (gold sulphite, mild alkaline solution with pH = 9 Gold ECF 60, brightener E3) containing 10 g/dm gold from Metalor. Some analytical and measurement results of magnetic atom traps are also presented in this paper. [less ▲]

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See detailHyperhidrose palmaire et axillaire.
Uhoda, Emmanuelle ULiege; Pierard, Gérald ULiege

in Dermatologie Actualité (2004), 84

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See detailEarly neurophysiological diagnosis of true neurogenic « thoracic outlet syndrome » (TOS)
HUA, MT; DUBUISSON, Annie ULiege; Zeevaert, Bernard et al

in Journal of Neurology (2004)

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See detailCervical artery dissection: An atypical presentation with Ehlers-Danlos-like collagen pathology?
Ulbricht, D.; Diederich, N. J.; Hermanns-Lê, Trinh ULiege et al

in Neurology (2004), 63(9), 1708-10

The authors took skin biopsies of the macroscopically normal skin of seven consecutive patients with spontaneous cervical artery dissection (SCAD). Histologically, alterations of the collagen and elastic ... [more ▼]

The authors took skin biopsies of the macroscopically normal skin of seven consecutive patients with spontaneous cervical artery dissection (SCAD). Histologically, alterations of the collagen and elastic fiber networks were found in six patients. In five, the histologic, immunohistochemical, and ultrastructural changes were similar to those usually found in Ehlers-Danlos syndrome (EDS). This suggests that SCAD is frequently associated with the dermal alterations seen in EDS. [less ▲]

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See detailModel Of Forest Carbon Sequestration Incorporating Aerial Wood Radiative Budget
Longdoz, Bernard ULiege; Aubinet, Marc ULiege; François, Louis ULiege

in Agricultural and Forest Meteorology (2004), 125(1-2), 83-104

The CHANCE model, simulating CO2, energy and water fluxes in a forest ecosystem, is presented. The components of the simulated canopy are the leaves, the branches, the trunks and the soil. The first three ... [more ▼]

The CHANCE model, simulating CO2, energy and water fluxes in a forest ecosystem, is presented. The components of the simulated canopy are the leaves, the branches, the trunks and the soil. The first three are divided into sunny and shaded zones. The model has been calibrated and validated in comparison with measurements performed in the temperate beech forest of Vielsalm (Belgium). For the reproduction of half-hourly net CO2 fluxes, the quality of the CHANCE results is comparable to other models (systematic error of 14%—0.51 molm−2 s−1, R2 = 0.79). The differences between simulated and measured fluxes result essentially from noise in the data, underestimation of the stomatal conductance during very dry days and heterogeneity of the south, southeast sector (presence of conifer patches). Three sensitivity tests have been performed. The first one, neglecting the contribution of aerial wood in the radiation budget, doubles the annual carbon sequestration (Seco). This trend is strengthened in the second test where common radiative and photosynthetic properties are assigned to leaves and branches. The third test induces a 30% reduction of Seco when the calculation of canopy component temperatures using the complete energy balance is replaced by the use of air temperature. © 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailThe contribution of 211 particles to the mechanical reinforcement mechanism of 123 superconducting single domains
Mathieu, Jean-Philippe; Cano, I. G.; Koutzarova, T. et al

in Superconductor Science and Technology (2004), 17(1), 169-174

Hardness and fracture toughness of Dy-123 single domains were studied by Vickers in micro-indentation. A significant anisotropy of the mechanical properties was observed. Hardness tests give higher values ... [more ▼]

Hardness and fracture toughness of Dy-123 single domains were studied by Vickers in micro-indentation. A significant anisotropy of the mechanical properties was observed. Hardness tests give higher values when performed in (001) planes rather than in planes parallel to the c-axis. Moreover, the cracks pattern around the indentation follows preferential orientation in planes parallel to the c-axis whereas a classical 'four-cracks' pattern is observed in the (001) planes. It has been possible to show the crucial role played by the 211 particles in the deviating mechanism of cracks and the relevance of the high homogeneity of 211-particle distribution in the material. [less ▲]

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See detailMédiation esthétique, médiatisation, destination
Servais, Christine ULiege

in Communication (2004), 23/2(Automne), 9-25

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See detailBiphasic response to nitric oxide of spinal trigeminal neurons with meningeal input in rat--possible implications for the pathophysiology of headaches
Koulchitsky, Stanislav ULiege; Fischer, M. J.; De Col, Roberto et al

in Journal of Neurophysiology (2004), 92(3), 1320-8

Nitric oxide (NO) is suggested to play a causative role in the pathogenesis of primary headaches. Infusion of NO donors can trigger headache attacks, and products of NO metabolism are found to be ... [more ▼]

Nitric oxide (NO) is suggested to play a causative role in the pathogenesis of primary headaches. Infusion of NO donors can trigger headache attacks, and products of NO metabolism are found to be increased in the cranial circulation in patients suffering from such headaches. To examine if NO is involved in mediating and maintaining spinal trigeminal neuronal activity, an animal model of meningeal nociception was used. In barbiturate-anesthetized rats, a cranial window was made to expose the parietal dura mater. An access to the medullary brain stem allowed extracellular action potentials to be recorded from neurons in the spinal trigeminal nucleus that received afferent input from the exposed dura. Slow intravenous infusion of the NO donor, sodium nitroprusside (SNP, 50 microg/kg), transiently increased spontaneous activity in a subset of neurons and, with a latency of 50 min, caused a progressive increase in impulse activity across the entire sample of neurons. A similar pattern of delayed activation was seen after topical application of the same dose of SNP onto the exposed medulla. Slow injection of the nonspecific inhibitor of NO synthase, N(omega)-nitro-l-arginine methyl ester (20 mg/kg), reduced the spontaneous activity in all neurons within 15 min. The results suggest that NO can induce delayed, slowly developing activation of central trigeminal neurons and that endogenous release of NO may contribute to the ongoing activity of these neurons. The delayed changes in neuronal activity may include gene expression of pro-nociceptive mediators. These mechanisms may be relevant for the pathogenesis of chronic headaches. [less ▲]

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See detailGenome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis
Vermeire, S.; Rutgeerts, P.; Van Steen, Kristel ULiege et al

in Gut (2004), 53(7), 980-986

Background and aims: Genome wide scans in inflammatory bowel disease (IBD) have indicated various susceptibility regions with replication of 16cen (IBD1), 12q (IBD2), 6p (IBD3), 14q11 (IBD4), and 3p21. As ... [more ▼]

Background and aims: Genome wide scans in inflammatory bowel disease (IBD) have indicated various susceptibility regions with replication of 16cen (IBD1), 12q (IBD2), 6p (IBD3), 14q11 (IBD4), and 3p21. As no linkage was previously found on IBD regions 3, 7, 12, and 16 in Flemish IBD families, a genome wide scan was performed to detect other susceptibility regions in this population. Methods: A cohort of 149 IBD affected relative pairs, all recruited from the Northern Flemish part of Belgium, were genotyped using microsatellite markers at 12 cM intervals, and analysed by Genehunter non-parametric linkage software. All families were further genotyped for the three main Crohn's disease associated variants in the NOD2/CARD15 gene. Results: Nominal evidence for linkage was observed on chromosomes 1 (D1S197: multipoint nonparametric linkage (NPL) score 2.57, p = 0.004; and at D1S305-D1S252: NPL 2.97, p = 0.001), 4q (D4S406: NPL 1.95, p = 0.03), 6q16 (D6S314: NPL 2.44, p = 0.007), 10p12 (D10S197: NPL 2.05, p = 0.02), 11q22 (D11S35-D11S927: NPL 1.95, p = 0.02) 14q11-12 (D14S80: NPL 2.41, p = 0.008), 20p12 (D20S192: NPL 2.7, p = 0.003), and Xq (DXS990: NPL 1.70, p = 0.04). A total of 51.4% of patients carried at least one NOD2/CARD15 variant. Furthermore, epistasis was observed between susceptibility regions 6q/10p and 20p/10p. Conclusion: Genome scanning in a Flemish IBD population found nominal evidence for linkage on 1p, 4q, 10p12, and 14q11, overlapping with other genome scan results, with linkage on 14q11-12 supporting the IBD4 locus. The results further show that epistasis is contributing to the complex model of IBD and indicate that population heterogeneity is not to be underestimated. Finally, NOD2/CARD15 is clearly implicated in the Flemish IBD population. [less ▲]

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See detailCoping with mild inflammatory catamenial acne: a clinical and bioinstrumental split-face assessment.
Petit, Ludivine; Pierard, Claudine ULiege; Uhoda, Emmanuelle ULiege et al

in Skin Research & Technology (2004), 10(4), 278-82

BACKGROUND: Acne is a multifactorial disease exhibiting distinct clinical presentations. Among them, the catamenial type is a matter of concern for young women. Some oral contraceptives may help without ... [more ▼]

BACKGROUND: Acne is a multifactorial disease exhibiting distinct clinical presentations. Among them, the catamenial type is a matter of concern for young women. Some oral contraceptives may help without, however, clearing the skin condition. AIM: The present open study aimed at evaluating the effect of overnight applications of a paste made of petrolatum,15% zinc oxide and 0.25% miconazole nitrate. METHOD: The split-face trial was conducted in 35 women. A non-medicated cream was used as control. Clinical evaluations and biometrological assessments on cyanoacrylate follicular biopsies were performed monthly for 3 months. Comedometry and the density in autofluorescent follicular casts were used as analytical parameters. In addition, the five most severe cases at inclusion were tested at the completion of the study for follicular bacterial viability using dual flow cytometry. RESULTS: Compared with baseline and to the control hemi-face, the medicated paste brought significant improvement of acne. The number of papules and their redness were reduced beginning with the first treatment phase. A reduction in the follicular fluorescence was yielded beginning with the second treatment phase. The ratios between injured and dead bacteria, on the one hand, and live bacteria, on the other hand were significantly increased at completion of the study. CONCLUSION: A miconazole paste applied for 1 week at the end of the ovarian cycle has a beneficial effect on catamenial acne. [less ▲]

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See detailEndocrine profiles, haematology and pregnancy outcomes of late pregnant Holstein dairy heifers sired by bulls giving a high or low incidence of stillbirth
Kornmatitsuk, B.; Dahl, E.; Ropstad, E. et al

in Acta Veterinaria Scandinavica (2004), 45(1-2), 47-68

The high incidence of stillbirth in Swedish Holstein heifers has increased continuously during the last 15 years to an average of 11% today. The pathological reasons behind the increased incidence of ... [more ▼]

The high incidence of stillbirth in Swedish Holstein heifers has increased continuously during the last 15 years to an average of 11% today. The pathological reasons behind the increased incidence of stillbirth are unknown. The present experiment was undertaken to investigate possible causes of stillbirth and to study possible physiological markers for predicting stillbirth. Twenty Swedish Holstein dairy heifers sired by bulls with breeding values for a high risk of stillbirth (n = 12) (experimental group) and a low risk of stillbirth (n = 8) (control group, group B) were selected based on information in the Swedish A1-data base. The experimental group consisted of 2 subgroups of heifers (groups A1 and A2) inseminated with 2 different bulls with 3.5% and 9% higher stillbirth rates than the average, and the control group consisted of heifers pregnant with 5 different bulls with 0%-6% lower stillbirth rates than the average. The bull used for group A1 had also calving difficulties due to large calves as compared to the bull in group A2 showing no calving difficulties. The heifers were supervised from 6-7 months of pregnancy up to birth, and the pregnancies and parturitions were compared between groups regarding hormonal levels, haematology, placental characteristics and calf viability. In group A1, 1 stillborn, 1 weak and 4 normal calves were recorded. In group A2, 2 stillborn and 4 normal calves were registered. All animals in the control group gave birth to a normal living calf without any assistance. The weak calf showed deviating profiles of body temperature, saturated oxygen and heart rates, compared with the normal living calves. No differences of the placentome thickness, measured in vivo by Ultrasonography were seen between the groups. The number of leukocytes and differential cell counts in groups A1 and A2 followed the profiles found in the control group. In group A1, a slight decrease of oestrone sulphate (E1S04) levels was found in the animal delivering a stillborn calf from the first 24-h blood sampling at 6 weeks to the second at 3 weeks prior to delivery, while the levels of E1S04 at both periods in the animal delivering a weak calf followed the profile in animals delivering a normal living calf. During late pregnancy and at the time of parturition, the levels of E1SO4 and PAGs in animals delivering a stillborn or weak calf (from group A1) followed the normal profiles found in animals delivering a normal living calf. In group A2, low levels of E1SO4 and pregnancy associated glycoproteins (PAGs) over 24 h at both 3 and 6 weeks prior to parturition (<1.5 nmol/L) were recorded in animals delivering a stillborn calf During late pregnancy and parturition, the levels of E1SO4 and PAGs were slightly lower during 30-50 days prior to delivery and increased with a lower magnitude at the time of parturition. In conclusion, our results indicate that the aetiology behind stillbirth varies depending on the AI-bulls used and is associated with dystocia or low viability of the calves. Deviating profiles of oestrone sulphate (E1SO4) and pregnancy associated glycoproteins (PAGs) in animals delivering a stillborn calf not caused by dystocia were observed, suggesting placental dysfunction as a possible factor. The finding suggests that the analyses of E1SO4 and PAGs could be used for monitoring foetal well-being in animals with a high risk of stillbirth at term. [less ▲]

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See detailDesign of a versatile device for measuring whole plant gas exchanges in Arabidopsis thaliana
Tocquin, Pierre ULiege; Périlleux, Claire ULiege

in New Phytologist (2004), 162(1), 223-229

Because of its small size and rosette growth habit, measuring gas exchanges in Arabidopsis thaliana is difficult with standard leaf cuvettes. Here, we designed a versatile system that is usable at the ... [more ▼]

Because of its small size and rosette growth habit, measuring gas exchanges in Arabidopsis thaliana is difficult with standard leaf cuvettes. Here, we designed a versatile system that is usable at the whole rosette level, as small as possible for fast and accurate measurements, but adaptable to plant size, and suitable for in situ measurements whatever the growing substrate of the plant. This cuvette is in two parts: the basic unit, which contains the sensors and is connected to the infra-red gas analyzer, and the clear chamber, where the rosette is enclosed. We made a set of three interchangeable chambers of different sizes to measure the rate of CO2 assimilation [A] of 26-, 33- and 40-d-old plants. The dependence of A to light irradiance and to intercellular CO2 concentration was recorded as typical response curves, which validate our device. Measurements were not only consistent in saturating conditions, but accurate CO2 exchange measurements in limiting conditions also reflected important physiological features related to plant ageing. [less ▲]

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See detailL’héritage et l’archive
Badir, Sémir ULiege; Baetens, Jan

in Protée (2004), 32(2), 5-8

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See detailBaseline health-related quality-of-life data as prognostic factors in a phase III multicentre study of women with metastatic breast cancer
Efficace, F.; Biganzoli, L.; Piccart, M. et al

in European Journal of Cancer (2004), 40(7), 1021-1030

The potential value of baseline health-related quality-of-life (HRQOL) and clinical factors in predicting prognosis was examined using data from an international randomised phase III trial which compared ... [more ▼]

The potential value of baseline health-related quality-of-life (HRQOL) and clinical factors in predicting prognosis was examined using data from an international randomised phase III trial which compared doxorubicin and paclitaxel with doxorubicin and cylophosphamide as first line chemotherapy in 275 women with metastatic breast cancer. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and the related breast module (QLQ-BR23) were used to assess baseline HRQOL data. The Cox proportional-hazards regression model was used for both univariate and multivariate analyses of survival. In the univariate analyses, performance status (P < 0.001) and number of sites involved (P = 0.001) were the most important clinical prognostic factors. The HRQOL variables at baseline most strongly associated with longer survival were better appetite, physical and role functioning, as well as less fatigue (P < 0.001). The final multivariate model retained performance status (P < 0.001) and appetite loss (P = 0.005) as the variables best predicting survival. Substantial loss of appetite was the only independent HRQOL factor predicting poor survival and was strongly correlated (\r\ > 0.5) with fatigue, role and physical functioning. In addition to known clinical factors, appetite loss appears to be a significant prognostic factor for survival in women with metastatic breast cancer. However, the mechanism underlying this association remains to be precisely defined in future studies. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailDatabase and general modelling concepts for groundwater modelling in the SQUASH Project
Orban, Philippe ULiege; Popescu, Ileana-Cristina; Ruthy, Ingrid ULiege et al

in Hidrotehnica (2004), 49(9-10), 51-57

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See detailMélanges fleuris et insectes auxiliaires
Francis, Frédéric ULiege; Colignon, P.; Haubruge, Eric ULiege

in Canard Déchaîné du Kauwberg (Le) (2004), 50

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See detailComment amorcer la construction identitaire d'un praticien réflexif par la formation initiale ?
Beckers, Jacqueline ULiege

in Recherche et Formation (2004), 46

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See detailSynopsis des mécanismes pathogéniques des toxidermies graves.
Paquet, Philippe ULiege; Pierard, Gérald ULiege

in Dermatologie Actualité (2004), 85

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See detailLe cas clinique du mois. Purpura révélateur d'un rhumatisme articulaire aigu.
Fumal, I.; Henry, Frédérique ULiege; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2004), 59(11), 630-2

We report the case of an adult who presented cutaneous manifestations of rheumatic fever. The lesions are rarely diagnosed. However, they represent a clue inciting a specific diagnostic search for ... [more ▼]

We report the case of an adult who presented cutaneous manifestations of rheumatic fever. The lesions are rarely diagnosed. However, they represent a clue inciting a specific diagnostic search for identifying the disease. [less ▲]

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See detailRegistration and real-time visualization of transcranial magnetic stimulation with 3-D MR images.
Noirhomme, Quentin ULiege; Ferrant, Matthieu; Vandermeeren, Yves et al

in IEEE Transactions on Biomedical Engineering (2004), 51(11), 1994-2005

This paper describes a method for registering and visualizing in real-time the results of transcranial magnetic stimulations (TMS) in physical space on the corresponding anatomical locations in MR images ... [more ▼]

This paper describes a method for registering and visualizing in real-time the results of transcranial magnetic stimulations (TMS) in physical space on the corresponding anatomical locations in MR images of the brain. The method proceeds in three main steps. First, the patient scalp is digitized in physical space with a magnetic-field digitizer, following a specific digitization pattern. Second, a registration process minimizes the mean square distance between those points and a segmented scalp surface extracted from the magnetic resonance image. Following this registration, the physician can follow the change in coil position in real-time through the visualization interface and adjust the coil position to the desired anatomical location. Third, amplitude of motor evoked potentials can be projected onto the segmented brain in order to create functional brain maps. The registration has subpixel accuracy in a study with simulated data, while we obtain a point to surface root-mean-square error of 1.17+/-0.38 mm in a 24 subject study. [less ▲]

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See detailAgeing across the life span: time to think again.
Pierard, Gérald ULiege

in Journal of Cosmetic Dermatology (2004), 3(1), 50-3

Living organisms are subject to ageing. This natural process has gained greater importance in socially and medically affluent societies. For many, ageing connotes unattractive changes in the appearance of ... [more ▼]

Living organisms are subject to ageing. This natural process has gained greater importance in socially and medically affluent societies. For many, ageing connotes unattractive changes in the appearance of the skin. The gross morphological changes of ageing skin are mirrored by a range of more profound age-associated physiological declines. Thus, skin ageing can be put into other perspectives which lie at the interfaces of molecular biology, cellular biology, oncology and cosmetic dermatology. Genetically programmed replicative senescence and stress-induced premature senescence (SIPS) are two processes that are fundamental to skin ageing. Some iteroparous species can be used as animal models for human ageing. Undoubtedly, scientific understanding of skin ageing is firmly rooted in the distinction between intrinsic and extrinsic types of ageing. However, seven major types of skin ageing can be distinguished: genetic, chronological, solar, behavioural, endocrinological, catabolic and gravitational types. Preventative measures can target each of these. [less ▲]

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See detailLe WOCCQ, un outil de diagnostic des risques psychosociaux liés au travail. Création de normes et développement d'une base de données
Hansez, Isabelle ULiege; Mahy, Aude; Grisard, Anne et al

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2004), 41(2), 79-84

Le taux d’emploi des travailleurs âgés de plus de 55 ans en Belgique est un des plus faibles d’Europe. Notre pays est loin d’atteindre les objectifs de taux d’emploi inscrits dans la Stratégie Européenne ... [more ▼]

Le taux d’emploi des travailleurs âgés de plus de 55 ans en Belgique est un des plus faibles d’Europe. Notre pays est loin d’atteindre les objectifs de taux d’emploi inscrits dans la Stratégie Européenne de l’Emploi. Ce constat doit donc inciter les autorités publiques, les entreprises et les travailleurs à réagir. Si les premières ont commencé à mettre en place des mesures structurelles pour remédier au problème, les entreprises et les travailleurs ne sont pas toujours conscients de la marge de manœuvre dont ils disposent pour relever le défi. Les stéréotypes des unes et une certaine culture du « droit à la retraite » des autres sont des obstacles de première ligne. C’est pourquoi il est primordial d’engager des sensibilisations à leur égard. Cet article présente les résultats d’une recherche menée auprès de travailleurs belges pour évaluer les motifs de départ, et la place des conditions de travail et du stress dans l’explication des retraits prématurés. Les résultats fournissent un matériel solide pour orienter non seulement la sensibilisation, mais aussi les actions à mettre en place au sein des entreprises pour encourager le maintien dans l’emploi des plus âgés. On notera par exemple que la prévention doit débuter avec les travailleurs dès l’âge de 46 ans, que la lutte contre le stress lié aux conditions de travail est nécessaire mais non suffisante pour prévenir les retraits prématurés, et qu’il faut surtout se concentrer sur une meilleure gestion des changements organisationnels et la valorisation du personnel pour endiguer les départs anticipés. [less ▲]

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See detailLa responsabilité des administrateurs provisoires de sociétés en cas de violation d'une obligation légale
Caprasse, Olivier ULiege

in Droit des Affaires : Revue Internationale du Droit des Affaires = Ondernemingsrecht : Internationaal Tijdschrift voor Ondernemingsrecht [= DA OR] (2004)

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See detailRecombinant human estrogen, androgen and progesterone receptors for detection of potential endocrine disruptors
Scippo, Marie-Louise ULiege; Argiris, Catherine; Van de Weerdt, Cécile ULiege et al

in Analytical and Bioanalytical Chemistry (2004), 378(3), 664-669

This work reports the binding capacity of various chemicals (so-called endocrine disruptors) to recombinant human steroid receptors (hERalpha, hPR and hAR). The tested chemicals are organochlorine ... [more ▼]

This work reports the binding capacity of various chemicals (so-called endocrine disruptors) to recombinant human steroid receptors (hERalpha, hPR and hAR). The tested chemicals are organochlorine insecticides (DDT and its metabolites, methoxychlor, aldrin, dieldrin, chlordecone, lindane, trichlorobenzene), estrogenic insecticides (endosulfan, toxaphene, nonachlor), herbicides (alachlor and atrazine), fungicides (benomyl and vinclozolin), industrial chemicals (nonylphenol, bisphenol A, diphenylphtalate), antioxidants (butylated hydroxyanisol) and some phytoestrogens. Except for phytoestrogens, most of the tested chemicals (DDT and its metabolites, aldrin, alpha- and beta-endosulfan, toxaphen, trans-nonachlor) show higher affinities for hPR than for hERalpha, indicating that the interaction with the progesterone receptor could contribute to the endocrine-disrupting effects imputed to these chemicals. We propose to use binding assays using recombinant human steroid receptors as screening tools for the detection of endocrine disruptors in various samples. [less ▲]

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See detailVaricella-Zoster virus proteins encoded by open reading frames 14 and 67 are both dispensable for the establishment of latency in a rat model.
Grinfeld, Esther; Sadzot-Delvaux, Catherine ULiege; Kennedy, Peter G E

in Virology (2004), 323(1), 85-90

A rat model of Varicella-Zoster virus (VZV) provides a system in which to investigate the molecular determinants of viral latency in dorsal root ganglia (DRG). In this study, we determined whether the VZV ... [more ▼]

A rat model of Varicella-Zoster virus (VZV) provides a system in which to investigate the molecular determinants of viral latency in dorsal root ganglia (DRG). In this study, we determined whether the VZV glycoproteins gC and gI, corresponding to VZV open reading frames (ORFs) 14 and 67, respectively, were required for the establishment of latency in this model. A VZV gI deletion mutant (DeltagI) derived from a recombinant Oka (rOka) cosmid and a gC null mutant obtained from a clinical isolate were inoculated into the footpads of 6-week-old rats, and the presence of viral DNA and eight different VZV RNA transcripts corresponding to the three classes of genes was investigated by in situ RT-PCR amplification and in situ hybridization (ISH) in the DRG at 1 week, 1 month, and 18-24 months after infection. VZV DNA and restricted RNA expression was established with both deletion mutants as well as the parental rOka virus. Both VZV DNA and RNA were detected in neurons and non-neuronal cells. The pattern of viral RNA expression detected with both gC and gI mutants was restricted with transcripts for VZV genes 62 and 63 most frequently expressed 18-24 months after infection. Transcripts for VZV genes 18, 28, and 29 were also detected at these time points but at a slightly lower frequency. Transcripts for the late gene 40 were never detected. We conclude that VZV ORFs 14 and 67 are dispensable for the establishment of a latent infection in this model. [less ▲]

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See detailMineral mapping in salt lakes from Sud Lipez (Bolivia) using Aster images
Caceres, Fernando; Ali-Ammar, Hamid; Pirard, Eric ULiege

in Geological Remote Sensing Group Newsletter (2004), (38), 15-19

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See detailFully automated method for the liquid chromatographic-tandem mass spectrometric determination of cyproterone acetate in human plasma using restricted access material for on-line sample clean-up.
Christians, Benoit; Fillet, Marianne ULiege; Chiap, Patrice ULiege et al

in Journal of Chromatography. A (2004), 1056(1-2), 105-10

A new automated method for the quantitative analysis of cyproterone acetate (CPA) in human plasma has been developed using on-line solid phase extraction (SPE) prior to the LC-MS/MS determination. The ... [more ▼]

A new automated method for the quantitative analysis of cyproterone acetate (CPA) in human plasma has been developed using on-line solid phase extraction (SPE) prior to the LC-MS/MS determination. The method was based on the use of a pre-column packed with internal-surface reversed-phase material (LiChrospher RP-4 ADS, 25 mm x 2 mm) for sample clean-up coupled to LC separation on an octadecyl silica stationary phase by means of a column switching system. A 30 microl plasma sample volume was injected directly onto the pre-column using a mixture of water, acetonitrile and formic acid (90:10:0.1 (v/v/v)) adjusted to pH 4.0 with diluted ammonia as washing liquid. The analyte was then eluted in the back-flush mode with the LC mobile phase consisting of water, methanol and formic acid (10:90:0.1 (v/v/v)). The dispensing flow rates of the washing liquid and the LC mobile phase were 300 microl min(-1). Medroxyprogesterone acetate (MPA) was used as internal standard. The MS ionization of the analytes was achieved using electrospray (ESI) in the positive ion mode. The pseudomolecular ionic species of CPA and MPA (417.4 and 387.5) were selected to generate daughter ions at 357.4 and 327.5, respectively. Finally, the developed method was validated according to a new approach using accuracy profiles as a decision tool. Very good results with respect to accuracy, detectability, repeatability, intermediate precision and selectivity were obtained. The LOQ of cyproterone acetate was 300 pg ml(-1). [less ▲]

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See detailAggregate Matching Efficiency: A Stochastic Production Frontier Approach, France 1990–1994
Ibourk, Aomar; Maillard, Bénédicte; Perelman, Sergio ULiege et al

in Empirica (2004), 31

We evaluate the determinants of aggregate matching efficiency changes through a stochastic translog production frontier model. The efficiency coefficient is represented by a stochastic function of ... [more ▼]

We evaluate the determinants of aggregate matching efficiency changes through a stochastic translog production frontier model. The efficiency coefficient is represented by a stochastic function of variables meant to capture workers and firms characteristics. The model is estimated on French data covering twenty-two regions from March 1990 till February 1995. Our estimates suggest that aggregate matching efficiency has decreased steadily in the early nineties. There are also wide cross-regional differences. On average, about 30% of the variations of efficiency observed across time and regions can be related to changes in the explanatory variables used in the model. The most important explanatory variables are the proportion of youngsters, females and immigrants in the stock of job seekers. Long-term unemployment has a significant negative effect, population density a significant positive one. The huge decline in the proportion of permanent job offers has apparently little effect on matching efficiency. [less ▲]

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See detailReduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling
Conzelmann, Holger; Saez-Rodriguez, Julio; Sauter, Thomas et al

in IEE Proceedings - Systems Biology (2004), 1(1), 159-169

Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain ... [more ▼]

Biological systems and, in particular, cellular signal transduction pathways are characterised by their high complexity. Mathematical models describing these processes might be of great help to gain qualitative and, most importantly, quantitative knowledge about such complex systems. However, a detailed mathematical description of these systems leads to nearly unmanageably large models, especially when combining models of different signalling pathways to study cross-talk phenomena. Therefore, simplification of models becomes very important. Different methods are available for model reduction of biological models. Importantly, most of the common model reduction methods cannot be applied to cellular signal transduction pathways. Using as an example the epidermal growth factor (EGF) signalling pathway, we discuss how quantitative methods like system analysis and simulation studies can help to suitably reduce models and additionally give new insights into the signal transmission and processing of the cell [less ▲]

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See detailAlternative Didaktik im Fremdsprachenunterricht im Zeitraum 1945-1980. Ein Beitrag zur Geschichte der Didaktik
Vanhaegendoren, Koen ULiege

in Zeitschrift der Germanisten Rumäniens (2004), 25-26

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See detailGenetic structuralism, psychological sociology and pragmatic social actor theory, Proposals for a convergence of French sociologies
Frère, Bruno ULiege

in Theory, Culture & Society (2004), 21(3), 85-99

This paper would like to show that Wittgenstein and Freud have exerted a considerable - though narrow - influence on Bourdieu's sociology. But they also pervade the theoretical development of two other ... [more ▼]

This paper would like to show that Wittgenstein and Freud have exerted a considerable - though narrow - influence on Bourdieu's sociology. But they also pervade the theoretical development of two other currents, which have emerged in French Sociology in the last few years, and were developed by L. Boltanski and L. Thevenot, on the one hand, and B. Lahire, on the other. Although they do not make it explicit, the advocates of these two currents have nevertheless been influenced by Wittgenstein and Freud. Thus Boltanski has drawn on Wittgenstein to develop a sociology which gives primacy to the social actor's interpretation of his or her situation through lay theorising. Lahire's work clearly pays a debt to Freud with his psychological sociology. It would therefore be interesting, in the first instance, to tease out how Wittgenstein and Freud, respectively, have influenced these two systems to demonstrate that they can indeed be used to generate new sociological currents, other than Bourdieu's own. This would then allow us to explore how they could be used to fill any gaps in Bourdieu's work, thus giving the latter renewed relevance and staunching its stagnating tendencies. But, ultimately, this analysis aims to show how Wittgenstein’s and Freud's theoretical influences can lead the way towards a theoretical synthesis between Bourdieu's critical sociology, Boltanski's social actor theory and Lahire's psychological sociology. Currently, these three currents operate independently of each other, without any kind of dialogue. And yet, far from being incompatible, these sociologies offer opportunities for exploring how they might complement each other and for mutual enrichment. [less ▲]

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See detailModeling the nitrogen fluxes in the Black Sea using a 3D coupled hydrodynamical-biogeochemical model: transport versus biogeochemical processes, exchanges across the shelf break and comparison of the shelf and deep sea ecodynamics
Grégoire, Marilaure ULiege; Beckers, Jean-Marie ULiege

in Biogeosciences (2004), 1(1), 33-61

A 6-compartment biogeochemical model of nitrogen cycling and plankton productivity has been coupled with a 3D general circulation model in an enclosed environment (the Black Sea) so as to quantify and ... [more ▼]

A 6-compartment biogeochemical model of nitrogen cycling and plankton productivity has been coupled with a 3D general circulation model in an enclosed environment (the Black Sea) so as to quantify and compare, on a seasonal and annual scale, the typical internal biogeochemical functioning of the shelf and of the deep sea as well as to estimate the nitrogen and water exchanges at the shelf break. Model results indicate that the annual nitrogen net export to the deep sea roughly corresponds to the annual load of nitrogen discharged by the rivers on the shelf. The model estimated vertically integrated gross annual primary production is 130 g C m(-2) yr(-1) for the whole basin, 220 g C m(-2) yr(-1) for the shelf and 40 g C m(-2) yr(-1) for the central basin. In agreement with sediment trap observations, model results indicate a rapid and efficient recycling of particulate organic matter in the sub-oxic portion of the water column (60-80 m) of the open sea. More than 95% of the PON produced in the euphotic layer is recycled in the upper 100 m of the water column, 87% in the upper 80 m and 67% in the euphotic layer. The model estimates the annual export of POC towards the anoxic layer to 4 10(10) mol yr(-1). This POC is definitely lost for the system and represents 2% of the annual primary production of the open sea. [less ▲]

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See detailNon-uniform adaptive vertical grids in one-dimensional numerical ocean models
Burchard, Hans; Beckers, Jean-Marie ULiege

in Ocean Modelling (2004), 6(1), 51-81

It is demonstrated in this paper how the concept of general vertical coordinates can be exploited for constructing adaptive grids in primitive equation ocean models. The term adaptive is used here in the ... [more ▼]

It is demonstrated in this paper how the concept of general vertical coordinates can be exploited for constructing adaptive grids in primitive equation ocean models. The term adaptive is used here in the sense of coordinate iso-surfaces which follow certain internal structures of the flow in such a way that higher vertical resolution is obtained in locations where vertical gradients are large. The internal structures considered here are shear and stratification. In this paper, one-dimensional models are applied in order to demonstrate the ability of such grid adaptation methods to follow internal structures even in flow situations dominated by vertical mixing processes. Here, a variational approach is considered for the generation of grids which results in a diffusion equation for the vertical coordinate. The method is tested for five different idealised and realistic scenarios with the result that the discretisation error can be significantly reduced in comparison to equidistant Cartesian grids. Some recommendations for extending these methods for three-dimensional models are given at the end of this paper. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailLe recyclage urbain en partenariat public-privé : le ''gap funding anglais'' et la ''revitalisation urbaine'' wallonne
Halleux, Jean-Marie ULiege

in Bulletin de la Société Géographique de Liège (2004), 44

Urban recycling and public-private partnership : the English « gap funding » and the Walloon « revitalisation urbaine » The English « gap funding » and the Walloon « revitalisation urbaine » are both ... [more ▼]

Urban recycling and public-private partnership : the English « gap funding » and the Walloon « revitalisation urbaine » The English « gap funding » and the Walloon « revitalisation urbaine » are both, mechanisms of public-private partnership aiming at increasing the financial profitability of urban recycling property development. The objective of their analysis is to understand why, compared with the situation in Wallonia, where the urban regeneration policy has not yet been emblematically successful, the gap funding mechanism has actually led to the renewal of several traditional urban areas. From this comparative investigation, which perfectly illustrates how partnerships are dependent of both, cultural and political traditions, we state that the English success is related with : political choices in favour of the concentration of subsidies within areas where the potential demand is strong, with the transparency of the private financial statements of account and also with a tradition of flexible planning, which is particularly in favour of the setting-up of partnership networks. [less ▲]

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See detailXPS data analysis via Wavelets and Fourier Transform.
Charles, Catherine ULiege; Rasson, Jean-Paul; Leclerc, Gervais

in Surface and Interface Analysis [=SIA] (2004), 36

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See detailL’application de la loi dans le temps en matière de roulage
Jacobs, Ann ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2004)

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See detailLa peine subsidiaire à une peine de travail
Jacobs, Ann ULiege

in Revue de Droit Pénal et de Criminologie (2004)

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See detailATP Augments von Willebrand Factor-dependent Shear-induced Platelet Aggregation through Ca2+-Calmodulin and Myosin Light Chain Kinase Activation
Oury, Cécile ULiege; Sticker, Elsie; Cornelissen, Heidi et al

in Journal of Biological Chemistry (2004)

Shear stress triggers von Willebrand factor (VWF) binding to platelet glycoprotein Ibalpha and subsequent integrin alpha(IIb)beta(3)-dependent platelet aggregation. Concomitantly, nucleotides are released ... [more ▼]

Shear stress triggers von Willebrand factor (VWF) binding to platelet glycoprotein Ibalpha and subsequent integrin alpha(IIb)beta(3)-dependent platelet aggregation. Concomitantly, nucleotides are released from plateletdense granules, and ADP is known to contribute to shear-induced platelet aggregation (SIPA). This study shows that ATP also contributes to SIPA. The ATP-gated P2X(1) ion channel induces MLC-mediated cytoskeletal rearrangements that increases platelet degranulation during VWF-triggered platelet activation. [less ▲]

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See detailOnline travel service quality: The role of pre-transaction services
Van Riel, Allard ULiege; Semeijn, Janjaap; Pauwels, Pieter

in Total Quality Management & Business Excellence (2004), 15(4), 475-493

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See detailHealth-related quality of life parameters as prognostic factors in a nonmetastatic breast cancer population: An international multicenter study
Efficace, F.; Therasse, P.; Piccart, M. J. et al

in Journal of Clinical Oncology (2004), 22(16), 3381-3388

Purpose The purpose of this research was to evaluate whether baseline health-related quality of life (HRQOL) parameters are prognostic factors for survival in locally advanced breast cancer patients ... [more ▼]

Purpose The purpose of this research was to evaluate whether baseline health-related quality of life (HRQOL) parameters are prognostic factors for survival in locally advanced breast cancer patients. Although the literature highlights the important role of HRQOL parameters in predicting survival in advanced metastatic disease, little evidence exists for earlier stages. Patients and Methods The overall sample consisted of 448 patients randomly assigned to receive cyclophosphamide, epirubicin, and fluorouracil versus epirubicin, cyclophosphamide, and granulocyte colony-stimulating factor. Patients were enrolled in 12 countries. HRQOL baseline scores were assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30. The Cox proportional hazards regression model was used for both univariate and multivariate analyses of survival. In addition, a bootstrap resampling technique was used to assess the stability of the outcomes. Bootstrap results were then applied for model averaging purposes as a means to account for the observed model selection uncertainty. Results The final multivariate model retained inflammatory breast cancer (T4d) as the only factor predicting overall survival (OS) with a hazard ratio of 1.375 (95% CI, 1.027 to 1.840; P = .03). The presence of inflammatory breast cancer lowers the median survival time from 6.6 to 4.2 years (36% reduction). None of the preselected HRQOL variables were prognostic for OS or disease-free survival, in either the univariate or multivariate analysis. Conclusion Our findings suggest that baseline HBQOL parameters have no prognostic value in a nonmetastatic breast cancer population. [less ▲]

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See detailAnálise bioestratigráfica do intervalo Llandoveriano da Bacia do Paraná no Paraguai Oriental
Mendlowicz Mauller, P.; Pereira, E.; Grahn, Y. et al

in Revista Brasiliera de Paleontologia (2004), 7(1), 199-212

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See detailHa una pistola per eliminare mio marito?
D'Amore, Salvatore ULiege

in Ecologia della Mente (2004), 26(1), 71-102

Recent theoretical and clinical contributions of elderly couple with alcoholic partner underlies the usefulness of pragmatic/interactive and semantic/symbolic approach of symptomatic situation ... [more ▼]

Recent theoretical and clinical contributions of elderly couple with alcoholic partner underlies the usefulness of pragmatic/interactive and semantic/symbolic approach of symptomatic situation. Particularly, alcohol-dependance is understood as related to developmental tasks, resources and bonds of life-cycle of elderly age. A psychotherapeutic process of elderly couple is narrated. This work is caractherized by the following phases: alcoholistic symptom control, individual and family story narration and renegociation and reshaping of couple spaces/times. Symptom gradual dissolution has permitted the relaunching of individual, couple and familial planning as a fundamental dimension for improving general quality life of elderly couple. [less ▲]

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See detailIntroducing the multivariate dale model in population-based genetic association studies
Van Steen, Kristel ULiege; Tahri, N.; Molenberghs, G.

in Biometrical Journal = Biometrische Zeitschrift (2004), 46(2), 187-202

Until recently, the most common parametric approaches to study the combined effects of several genetic polymorphisms located within a gene or in a small genomic region are, at the genotype level, logistic ... [more ▼]

Until recently, the most common parametric approaches to study the combined effects of several genetic polymorphisms located within a gene or in a small genomic region are, at the genotype level, logistic regressions and at the haplotype level, haplotype analyses. An alternative modeling approach, based on the case/control principle, is to regard exposures (e.g., genetic data such as derived from Single Nucleotide Polymorphisms - SNPs) as random and disease status as fixed and to use a marginal multivariate model that accounts for inter-relationships between exposures. One such model is the multivariate Dale model. This model is based on multiple logistic regressions. That is why the model, applied in a case/control setting, leads to straightforward interpretations that are similar to those drawn in a classical logistic modeling framework. [less ▲]

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See detailLe coût cognitif des processus orthographiques
Schelstraete, Marie-Anne; Maillart, Christelle ULiege

in Glossa (2004), 89

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See detailHREELS Signal Processing Via Wavelets.
Charles, Catherine ULiege; Leclerc, Gervais; Rasson, Jean-Paul

in Surface and Interface Analysis [=SIA] (2004), 36

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See detailIdentification of residues within human glycoprotein VI involved in the binding to collagen: evidence for the existence of distinct binding sites.
Lecut, Christelle ULiege; Arocas, Veronique; Ulrichts, Hans et al

in Journal of Biological Chemistry (2004), 279(50), 52293-9

Glycoprotein VI (GPVI) has a crucial role in platelet responses to collagen. Still, little is known about its interaction with its ligands. In binding assays using soluble or cell-expressed human GPVI, we ... [more ▼]

Glycoprotein VI (GPVI) has a crucial role in platelet responses to collagen. Still, little is known about its interaction with its ligands. In binding assays using soluble or cell-expressed human GPVI, we observed that (i) collagen, and the GPVI-specific ligands collagen-related peptides (CRP) and convulxin, competed with one another for the binding to GPVI and (ii) monoclonal antibodies directed against the extracellular part of the human receptor displayed selective inhibitory properties on GPVI interaction with its ligands. Monoclonal antibody 9E18 strongly reduced the binding of GPVI to collagen/CRP, 3F8 inhibited its interaction with convulxin, whereas 9O12 prevented all three interactions. These observations suggest that ligand-binding sites are distinct, exhibiting specific features but at the same time also sharing some common residues participating in the recognition of these ligands. The epitope of 9O12 was mapped by phage display, along with molecular modeling of human GPVI, which allowed the identification of residues within GPVI potentially involved in ligand recognition. Site-directed mutagenesis revealed that valine 34 and leucine 36 are critical for GPVI interaction with collagen and CRP. The loop might thus be part of a collagen/CRP-binding site. [less ▲]

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See detailPrincipal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formation.
Lecut, Christelle ULiege; Schoolmeester, Anne; Kuijpers, Marijke J E et al

in Arteriosclerosis, Thrombosis, and Vascular Biology (2004), 24(9), 1727-33

OBJECTIVE: High-shear perfusion of blood over collagen results in rapid platelet adhesion, aggregation, and procoagulant activity. We studied regulation of alpha2beta1 and alphaIIbbeta3 integrin ... [more ▼]

OBJECTIVE: High-shear perfusion of blood over collagen results in rapid platelet adhesion, aggregation, and procoagulant activity. We studied regulation of alpha2beta1 and alphaIIbbeta3 integrin activation during thrombus formation on collagen. METHODS AND RESULTS: Blockade of glycoprotein (GP) VI by 9O12 antibody or of P2Y purinergic receptors permitted platelet adhesion but reduced aggregate formation, fibrinogen binding, and activation of alpha2beta1 and alphaIIbbeta3, as detected with antibodies IAC-1 and PAC1 directed against activation-dependent epitopes of these integrins. Combined blockade of GPVI and P2Y receptors and thromboxane formation abolished integrin activation but still allowed adhesion of morphologically unstimulated, nonprocoagulant platelets. Exogenous ADP partly restored the suppressive effect of GPVI blockade on integrin alpha2beta1 and alphaIIbbeta3 activation. Adhesion was fully inhibited only with simultaneous blocking of GPVI and alpha2beta1, indicating that the integrin can support platelet-collagen binding in the absence of its activation. Blockade or absence of GPIbalpha only moderately influenced integrin activation and adhesion unless GPVI was inhibited. CONCLUSIONS: GPVI- and autocrine-released ADP induce affinity changes of alpha2beta1 and alphaIIbbeta3 during thrombus formation on collagen under flow. These integrin changes are dispensable for adhesion but strengthen platelet-collagen interactions and thereby collagen-induced platelet activation. Integrin activation during thrombus formation on collagen was studied using fluorescent-labeled antibodies IAC-1 and PAC1 directed against activation-dependent epitopes of alpha2beta1 and alphaIIbbeta3 integrin, respectively. Glycoprotein VI blockade by 9O12 antibody or P2Y ADP receptors reduced integrin activation along with aggregate formation and fibrinogen binding but not alpha2beta1-dependent adhesion. [less ▲]

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