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See detailComportamentais e Genéticos do Alcoolismo em uma Amostra da População do Vale do Rio Pardo, RS.
Köche, A.; Rieger, A.; Geller, F. et al

in Caderno Pesquisa. Série Biologia (2006)

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See detailLe collage-scellement des restaurations all-ceram
Van Heusden, Alain ULiege; Gueders, Audrey ULiege

in Revue Belge de Médecine Dentaire = Belgisch Tijdschrift voor Tandheelkunde (2006), 61(2), 109-21

The objective of this article is to synthesize the current scientific data relating to the bonding of ceramic restorations in order to present a reliable and reproductive clinical method for the general ... [more ▼]

The objective of this article is to synthesize the current scientific data relating to the bonding of ceramic restorations in order to present a reliable and reproductive clinical method for the general practitioner. The different ceramic treatments are explained with a distinction between those which can be etched and the others. A precise check list is suggested for the conditioning of dental tissues and ceramic surfaces. [less ▲]

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See detailAdoption d’un poulain et induction de la lactation chez une ponette Welsh
Ponthier, Jérôme ULiege; Deleuze, Stefan ULiege

in Pratique Vétérinaire Equine (2006), 38(151), 49-53

Privé de sa mère, un poulain orphelin est handicapé dans son développement physique et comportemental. Pour la survie du poulain et son intégration au groupe, il existe des méthodes pharmacologiques ... [more ▼]

Privé de sa mère, un poulain orphelin est handicapé dans son développement physique et comportemental. Pour la survie du poulain et son intégration au groupe, il existe des méthodes pharmacologiques d’induction de la lactation et du comportement maternel. [less ▲]

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See detailIntroduction générale
Beaufays, Jean ULiege; Verjans, Pierre ULiege

in Fédéralisme - Régionalisme (2006), 6(2005-2006),

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See detail"De novo" design of peptides with specific lipid-binding properties
Lins, Laurence ULiege; Charloteaux, Benoît ULiege; Heinen, C. et al

in Biophysical Journal (2006), 90(2), 470-479

In this study, we describe an in silico method to design peptides that can be made of non-natural amino acids and elicit specific membrane-interacting properties. The originality of the method holds in ... [more ▼]

In this study, we describe an in silico method to design peptides that can be made of non-natural amino acids and elicit specific membrane-interacting properties. The originality of the method holds in the capacities developed to design peptides from any non-natural amino acids as easily as from natural ones, and to test the structure stability by an angular dynamics rather than the currently-used molecular dynamics. The goal of this study was to design a non-natural tilted peptide. Tilted peptides are short protein fragments able to destabilize lipid membranes and characterized by an asymmetric distribution of hydrophobic residues along their helix structure axis. The method is based on the random generation of peptides and their election on three main criteria: mean hydrophobicity and the presence of at least one polar residue; tilted insertion at the level of the acyl chains of lipids of a membrane; and conformational stability in that hydrophobic phase. From 10,000,000 randomly-generated peptides, four met all the criteria. One was synthesized and tested for its lipid-destabilizing properties. Biophysical assays showed that the "de novo" peptide made of non-natural amino acids is helical either in solution or intolipids as tested by Fourier transform infrared spectroscopy and is able to induce liposome fusion. These results are in agreement with the calculations andvalidate the theoretical approach. [less ▲]

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See detailLe processus institutionnel en République Démocratique du Congo
Verjans, Pierre ULiege

in Revue Evangile et justice (2006)

Les élections de 2006 en République démocratique du Congo s'inscrivent dans un processus de transition démocratique, après une guerre civile sanglante. L'institutionnalisation des rapports sociaux passe ... [more ▼]

Les élections de 2006 en République démocratique du Congo s'inscrivent dans un processus de transition démocratique, après une guerre civile sanglante. L'institutionnalisation des rapports sociaux passe, après une phase d'écriture d'une nouvelle constitution, par l'approbation de ce texte par la population, en décembre 2005. [less ▲]

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See detailApprentissage coopératif et prises de parole en langue cible dans deux classes en immersion
Mattar, C.; Blondin, Christiane ULiege

in Canadian Modern Language Review = Revue Canadienne des Langues Vivantes (2006), 63(2), 225-253

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See detailModélisation hydrodynamique des zones inondables en Région wallonne
Pirotton, Michel ULiege; Erpicum, Sébastien ULiege; Dewals, Benjamin ULiege et al

in Cahiers de l'Urbanisme (Les) (2006)

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See detailQTL and candidate genes for fecundity in sows
Buske, Bernd ULiege; Sternstein, Ina; Brockmann, Gudrun

in Animal Reproduction Science (2006), 95(3), 167-183

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See detailSerum levels of soluble CD163 correlate with the inflammatory process in coeliac disease.
Daly, Adrian ULiege; Walsh, C.; Feighery, C. et al

in Alimentary Pharmacology & Therapeutics (2006), 24(3), 553-9

BACKGROUND: In coeliac disease, following the introduction of a gluten-free diet, monitoring mucosal disease activity requires repeated small intestinal biopsies. If a test measuring a circulating ... [more ▼]

BACKGROUND: In coeliac disease, following the introduction of a gluten-free diet, monitoring mucosal disease activity requires repeated small intestinal biopsies. If a test measuring a circulating inflammatory marker was available, this would be clinically valuable. AIM: To determine if levels of soluble CD163, a scavenger receptor shed by tissue macrophages, correlated with the inflammatory lesion in coeliac disease. METHODS: Serum samples were collected from 131 patients with untreated coeliac disease, 40 patients with treated coeliac disease, 92 non-coeliac disease control subjects and 131 healthy controls. A capture enzyme linked immunosorbance assay was established to measure levels of soluble CD163 in sera. The extent of the histological lesion in coeliac biopsies was assessed using a Marsh grading system. RESULTS: Levels of CD163 in untreated coeliac subjects were significantly elevated when compared with the treated coeliac patients, the disease control group and the healthy control subjects (P < 0.0001 in each instance). Moreover, coeliac patients with the most marked histological lesion (Marsh 3) had significantly higher levels of soluble CD163 than patients with Marsh grade 2 lesions (P < 0.0004), with grade 1 lesions (P < 0.0001) and grade 0 lesions (P < 0.0001). CONCLUSIONS: Measurement of soluble CD163 may be a useful method of monitoring the inflammatory lesion in coeliac disease. [less ▲]

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See detailInfluence of the non-linearity of the aerodynamic coefficients on the skewness of the buffeting drag force
Denoël, Vincent ULiege; Degée, Hervé ULiege

in Wind and Structures (2006), 9(6), 457-471

This paper is devoted to the non linear quasi-steady aerodynamic loading. A linear approximation is often used to compute the response of structures to buffeting forces. Some researchers have however ... [more ▼]

This paper is devoted to the non linear quasi-steady aerodynamic loading. A linear approximation is often used to compute the response of structures to buffeting forces. Some researchers have however shown that it is possible to account for the non linearity of this loading. This non linearity can come (i) from the squared velocity or (ii) from the shape of the aerodynamic coefficients (as functions of the wind angle of attack). In this paper, it is shown that this second origin can have significant implications on the design of the structure, particularly when the non linearity of the aerodynamic coefficient is important or when the transverse turbulence is important. [less ▲]

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See detailNyungwea, a new genus of lichen with goniocyst-producing stipes from Rwanda and Uganda (East Africa)
Sérusiaux, Emmanuel ULiege; Fischer, E.; Killmann, D.

in Lichenologist (2006), 38(Part 2), 115-121

The new genus and species Nyungwea pallida is characterized by a thin thallus lichenized with Trentepohlia and pale stipes producing goniocysts. Its taxonomic position is uncertain. It is named after the ... [more ▼]

The new genus and species Nyungwea pallida is characterized by a thin thallus lichenized with Trentepohlia and pale stipes producing goniocysts. Its taxonomic position is uncertain. It is named after the large pristine montane forest of Nyungwe in Rwanda (East Africa) where it was first found; it is also known from the Mabira forest in Uganda. [less ▲]

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See detailNormal and aberrant biological self-assembly: Insights from studies of human lysozyme and its amyloidogenic variants
Dumoulin, Mireille ULiege; Kumita, Janet; Dobson, Christopher M

in Accounts of Chemical Research (2006), 39

Studies of lysozyme have played a major role over several decades in defining the general principles underlying protein structure, folding, and stability. Following the discovery some 10 years ago that ... [more ▼]

Studies of lysozyme have played a major role over several decades in defining the general principles underlying protein structure, folding, and stability. Following the discovery some 10 years ago that two mutational variants of lysozyme are associated with systemic amyloidosis, these studies have been extended to investigate the mechanism of amyloid fibril formation. This Account describes our present knowledge of lysozyme folding and misfolding, and how the latter can give rise to amyloid disease. It also discusses the significance of these studies for our general understanding of normal and aberrant protein folding in the context of human health and disease. [less ▲]

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See detailSwitching mode of deformation in post-localization solutions with a quasi brittle material
Bésuelle, Pierre; Chambon, René; Collin, Frédéric ULiege

in Journal of Mechanics of Material and Structures (2006), 1(7), 1115-1134

Localization in a quasi brittle material is studied using a local second gradient model. Since localization takes place in a medium assumed to be initially homogeneous, non uniqueness of the solutions of ... [more ▼]

Localization in a quasi brittle material is studied using a local second gradient model. Since localization takes place in a medium assumed to be initially homogeneous, non uniqueness of the solutions of an initial boundary value problem is then also studied. Using enhanced models implies to generalize the classical localization analysis, especially it is necessary to study solutions more continuous (i.e., continuous up to the degree one) than the ones used in analysis involving classical constitutive equations. Within the assumptions done, it appears that localization is possible in the second gradient model if it is possible in the underlying classical model. Then the study of non uniqueness is conducted for the numerical problem, using different first guesses in the full Newton-Raphson procedure solving the incremental non linear equations. It turns out ¯nally that we are able thanks to this method to reproduce qualitatively the non reproducibility of usual experiment in the post peak regime. [less ▲]

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See detailLe Conseil d'Etat et la connexité
Donnay, Luc ULiege

in Journal des Tribunaux (2006), 6234

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See detailComparaison des performances zootechniques et du contenu en azote de l'effluent lors de l'élevage de porcs charcutiers sur caillebotis ou sur litière de paille accumulée.
Philippe, François-Xavier ULiege; Laitat, Martine ULiege; Vandenheede, Marc ULiege et al

in Annales de Médecine Vétérinaire (2006), 150(2), 137-144

Two identical rooms were arranged to house fattening pigs on a fully-slatted floor in one and on a straw-based deep litter in the other one. Each room was ventilated with an exhausted fan and the ... [more ▼]

Two identical rooms were arranged to house fattening pigs on a fully-slatted floor in one and on a straw-based deep litter in the other one. Each room was ventilated with an exhausted fan and the ventilation rates were adapted to have the same temperatures in the two rooms. Six successive batches of 16 pigs per pen were raised. The slurry pit was emptied and the litter removed after each fattening period. The mean daily weight gains of the pigs raised on slatted floor and on deep litter were of 742 and 729 g/day, the food conversion ratios 3.0 and 3.1 kg/kg, the lean meat percentages 59.8 and 60.0 % and the prices at slaughter 1.06 and 1.04 E/kg live weight, respectively. None of the differences was statistically significant. The amounts of slurry and manure produced were 290 and 187 kg per fattening pig, corresponding to 3.04 and 2.06 kg nitrogen per fattening pig, respectively. These differences were significant. [less ▲]

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See detailInfluence of excessive carbides upon strength of hot rolled rolls of steel similar to high speed grade
Lecomte-Beckers, Jacqueline ULiege; Herman, M.; Breyer, J. P.

in Stal' (2006), 9

This paper will illustrate the choice of the alloying elements and their content in the current grade. By using sophisticated laboratory examination techniques such as differential thermal analysis ... [more ▼]

This paper will illustrate the choice of the alloying elements and their content in the current grade. By using sophisticated laboratory examination techniques such as differential thermal analysis, scanning electron microscopy and image analysis, the metallurgical parameters of Aurora grade will be described and compared to those of the Kosmos grade. An attempt will also be made to connect all our laboratory results to the good behaviour of the alloy in operation in the early stands of Hot Strip Mills. [less ▲]

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See detailCan sea ice-specific biogeochemical processes support significant air-ice CO2 fluxes?
Delille, Bruno ULiege; Lannuzel, Delphine; Schoemann, Véronique et al

in Geophysical Research Abstracts (2006), 8

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See detail« Je Fais "Charlie" avec ce que j’estime être le meilleur au monde »
Dejasse, Erwin ULiege

in 9e Art : Les Cahiers du Musée de la Bande Dessinée (2006), 12

The article deals about "Charlie mensuel" magazine during the time when Georges Wolinski was the publisher.

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See detailSequential positron emission tomography using [18F]fluorodeoxyglucose for monitoring response to chemotherapy in metastatic breast cancer.
Couturier, Olivier; Jerusalem, Guy ULiege; N'Guyen, Jean-Michel et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2006), 12(21), 6437-43

PURPOSE: To evaluate the clinical value of positron emission tomography (PET) for monitoring chemotherapy in metastatic breast cancer. EXPERIMENTAL DESIGN: Twenty patients with hormonorefractory or ... [more ▼]

PURPOSE: To evaluate the clinical value of positron emission tomography (PET) for monitoring chemotherapy in metastatic breast cancer. EXPERIMENTAL DESIGN: Twenty patients with hormonorefractory or hormonoreceptor-negative multimetastatic breast cancer were prospectively included. PET studies were done at baseline, at day 21 after the first cycle and at day 21 after the third cycle of chemotherapy. Metabolic response was defined based on visual and various modes of standardized uptake value (SUV) analysis of sequential PET studies. RESULTS: After one cycle, PET indicated a partial response in 12 patients, stable disease in 7 patients, and progressive disease in 1 patient, according to the visual analysis. After three cycles, PET showed a complete response in 5 patients, partial response in 11 patients, stable disease in 3 patients, and progressive disease in 1 patient. Seventy-five percent of the patients showing a metabolic response on visual analysis effectively responded to the treatment. The average SUV decreased on both the second and the third PET study, but only changes measured after three cycles of chemotherapy predicted the clinical response to chemotherapy and the overall survival. All methods for calculating the SUV (normalized for body weight, body surface area, or lean body mass) provided similar results. CONCLUSION: Semiquantitative analysis of [18F]fluorodeoxyglucose-PET studies done after three cycles of chemotherapy is useful for monitoring the response to chemotherapy in metastatic breast cancer. [less ▲]

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See detailTechnique d'extraction de 12 benzodiazépines dans le plasma. Résultats expérimentaux multicentriques
Jourdil, Nicole; Capolaghi, Bernard; Artur, Michèle et al

in Annales de Toxicologie Analytique (2006), 2

Dans le cadre des différents thèmes de travail proposés aux membres de la commission de Toxicologie Clinique de la SFTA, une étude est réalisée sur l'identification et la quantification simultanée de 12 ... [more ▼]

Dans le cadre des différents thèmes de travail proposés aux membres de la commission de Toxicologie Clinique de la SFTA, une étude est réalisée sur l'identification et la quantification simultanée de 12 benzodiazépines dans le plasma. L'objectif est de tester la robustesse d'une technique d'extraction en l'imposant aux différents participants, les conditions chromatographiques de séparation et le mode de détection restant libres, fonctions de l'équipement de chaque laboratoire. L'étude a été réalisée sur une période de 2 mois et demi. Deux échantillons tests de plasmas surchargés avec 12 benzodiazépines à des concentrations thérapeutiques ou supra-thérapeutiques sont adressés à chaque centre d'investigation en vue de leur évaluation. La technique d'extraction utilise un mélange d'hexane / dichlorométhane en milieu tamponné (pH 9.2) et le loflazépate d'éthyle comme standard interne. Une méthode CLHP avec détecteur à barrette de diode est proposée à défaut par le laboratoire coordonnateur aux participants ne disposant pas de technique d'analyse. Sur les 11 participants, 10 utilisent une technique CLHP, un seul une technique CPG. Parmi les techniques CLHP, 2 d'entre elles associent un détecteur de masse, 7 un détecteur à barrette de diodes, 1 un détecteur UV. La technique CPG est associée à un détecteur de masse. L'analyse des résultats montre que la technique d'extraction proposée a été testée avec succès par 8/11 des participants : 4/11 laboratoires sans erreur et 4/11 laboratoires avec 1 ou 2 résultats exclus. Par contre, 3/11 laboratoires ont rencontré des difficultés majeures : un site par la survenue d'émulsions lors du traitement des échantillons tests (plasmas lyophilisés à reconstituer), un site par manque de temps et d'expérience, le troisième mettant en cause le choix du standard interne en technique CPG, le loflazépate d'éthyle n'ayant pas fait l'objet d'une étude préalable par cette technique. [less ▲]

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See detailEvaluation et prise en charge de la dangerosité des délinquants sexuels en Belgique (région wallonne)
Mormont, Christian ULiege; Coco, Geneviève ULiege

in Bulletin de Psychologie (2006), 59(1), 63-73

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See detailIntoxications au dextropropoxyphène et au tramadol: bilan d'un an de recueil
Cohen, Sabine; Manchon, Monique; Artur, Michèle et al

in Annales de Toxicologie Analytique (2006), 2

La prescription de plus en plus fréquente du dextropropoxyphène (DP) et du tramadol, deux antalgiques opioïdes, a conduit les membres du groupe de travail "Toxicologie hospitalière" de la Société ... [more ▼]

La prescription de plus en plus fréquente du dextropropoxyphène (DP) et du tramadol, deux antalgiques opioïdes, a conduit les membres du groupe de travail "Toxicologie hospitalière" de la Société Française de Toxicologie Analytique (SFTA) à étudier leur toxicité clinique observée. L'étude a consisté en l'analyse des cas où l'une ou l'autre de ces molécules a été identifiée au décours d'un screening toxicologique réalisé durant l'année 2004 dans les laboratoires hospitaliers des membres de ce groupe. Pour chaque patient ont été recueillis les données démographiques, les concentrations plasmatiques en dextropropoxyphène, norpropoxyphène (NP) ou tramadol, la concentration plasmatique en paracétamol, les médicaments associés et les signes cliniques (digestifs, respiratoires, cardiaques et neurologiques). Aucune relation entre les concentrations plasmatiques de dextropropoxyphène et de paracétamol, ni entre celles de dextropropoxyphène ou de tramadol et la gravité clinique n'a été observée. Les concentrations plasmatiques observées en dextropropoxyphène sont faibles mais doivent attirer l'attention sur une éventuelle intoxication au paracétamol. Les concentrations plasmatiques en tramadol peuvent être élevées mais les intoxications sont dans l'ensemble peu sévères et les concentrations toxiques semblent très supérieures à la concentration de 1 mg/L. [less ▲]

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See detailCompte rendu de Lloyd P. GERSON, "Aristotle and other Platonists"
Gavray, Marc-Antoine ULiege

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2006), 75

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See detailPositive and negative ion mode ESI-MS and MS/MS for studying drug-DNA complexes
Rosu, Frédéric ULiege; Pirotte, Sophie ULiege; De Pauw, Edwin ULiege et al

in International Journal of Mass Spectrometry (2006), 253(3), 156-171

We report systematic investigation of duplex DNA complexes with minor groove binders (Hoechsts 33258 and 33342, netropsin and DAPI) and intercalators (daunomycin, doxorubicin, actinomycin D, ethidium ... [more ▼]

We report systematic investigation of duplex DNA complexes with minor groove binders (Hoechsts 33258 and 33342, netropsin and DAPI) and intercalators (daunomycin, doxorubicin, actinomycin D, ethidium, cryptolepine, neocryptolepine, m-Amsacrine, proflavine, ellipticine and mitoxantrone) by ESI-MS and ESI-MS/MS in the negative ion mode and in the positive ion mode. The apparent solution phase equilibrium binding constants can be determined by measuring relative intensities in the ESI-MS spectrum. While negative ion mode gives reliable results, positive ion mode gives a systematic underestimation of the binding constants and even a complete suppression of the complexes for intercalators lacking functional groups capable of interacting in the grooves. In the second part of the paper we systematically compare MS/MS fragmentation channels and breakdown curves in the positive and the negative modes, and discuss the possible uses and caveats of MS/MS in drug-DNA complexes. In the negative mode, the drugs can be separated in three groups: (1) those that leave the complex with no net charge; (2) those that leave the complex with a negative charge; and (3) those that remain attached on the strands upon dissociation of the duplex due to their positive charge. In the positive ion mode, all complexes fragment via the loss of protonated drug. Information on the stabilization of the complex by drug-DNA noncovalent interactions can be obtained straightforwardly only in the case of neutral drug loss. In all other cases, proton affinity (in the positive ion mode), gas-phase basicity (in the negative ion mode) and coulombic repulsion are the major factors influencing the fragmentation channel and the dissociation kinetics. [less ▲]

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See detailImplementation of human papillomavirus testing in cervical screening without a concomitant decrease in participation rate.
Bulkmans, N. W. J.; BULK, Saskia ULiege; Ottevanger, M. S. et al

in Journal of clinical pathology (2006), 59(11), 1218-20

Adding high-risk human papillomavirus (hrHPV) testing to screening increases the efficacy of cervical screening programmes. However, hrHPV testing may result in a lower participation rate because of the ... [more ▼]

Adding high-risk human papillomavirus (hrHPV) testing to screening increases the efficacy of cervical screening programmes. However, hrHPV testing may result in a lower participation rate because of the perceived association with sexually transmitted infections. We describe how testing for hrHPV was added to cervical screening in the POpulation-BAsed SCreening study AMsterdam (POBASCAM) trial. Participation rates of the screening programme before and after hrHPV implementation were evaluated in the region where the POBASCAM trial was carried out. The participation rate was 58.7% before and 61.4% after the addition of hrHPV testing to screening (p<0.001). An inventory of frequently asked questions is presented. Thus, hrHPV testing can be added to cervical screening by cytology without a decrease in participation rate. [less ▲]

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See detailElectron photodetachment dissociation of DNA polyanions in a quadrupole ion trap mass spectrometer
Gabelica, Valérie ULiege; Tabarin, Thibault; Antoine, Rodolphe et al

in Analytical Chemistry (2006), 78(18), 6564-6572

We hereby explore the effects of irradiating DNA polyanions stored in a quadrupole ion trap mass spectrometer with an optical parametric oscillator laser between 250 and 285 nm. We studied DNA 6-20-mer ... [more ▼]

We hereby explore the effects of irradiating DNA polyanions stored in a quadrupole ion trap mass spectrometer with an optical parametric oscillator laser between 250 and 285 nm. We studied DNA 6-20-mer single strands and 12-base pair double strands. In all cases, laser irradiation causes electron detachment from the multiply charged DNA anions. Electron photodetachment efficiency directly depends on the number of guanines in the strand, and maximum efficiency is observed between 260 and 275 nm. Subsequent collision-induced dissociation (CID) of the radical anions produced by electron photodetachment results in extensive fragmentation. In addition to neutral losses, a large number of fragments from the w, d, a*, and z* ion series are obtained, contrasting with the w and (a-base) ion series observed in regular CID. The major advantage of this technique, coined electron photodetachment dissociation (EPD) is the absence of internal fragments, combined with good sequence coverage. EPD is therefore a highly promising approach for de novo sequencing of oligonucleotides. EPD of nucleic acids is also expected to give specific radical-induced strand cleavages, with conservation of other fragile bonds, including noncovalent bonds. In effect, preliminary results on a DNA hairpin and on double strands suggest that EPD could also be used to probe intra- and intermolecular interactions in nucleic acids. [less ▲]

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See detailPreferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands.
BULK, Saskia ULiege; Berkhof, J.; Bulkmans, N. W. J. et al

in British journal of cancer (2006), 94(1), 171-5

We present the type-distribution of high-risk human papillomavirus (HPV) types in women with normal cytology (n=1467), adenocarcinoma in situ (ACIS) (n=61), adenocarcinoma (n=70), and squamous cell ... [more ▼]

We present the type-distribution of high-risk human papillomavirus (HPV) types in women with normal cytology (n=1467), adenocarcinoma in situ (ACIS) (n=61), adenocarcinoma (n=70), and squamous cell carcinoma (SCC) (n=83). Cervical adenocarcinoma and ACIS were significantly more frequently associated with HPV18 (OR(MH) 15.0; 95% CI 8.6-26.1 and 21.8; 95% CI 11.9-39.8, respectively) than normal cytology. Human papillomavirus16 was only associated with adenocarcinoma and ACIS after exclusion of HPV18-positive cases (OR(MH) 6.6; 95% CI 2.8-16.0 and 9.4; 95% CI 2.8-31.2, respectively). For SCC, HPV16 prevalence was elevated (OR(MH) 7.0; 95% CI 3.9-12.4) compared to cases with normal cytology, and HPV18 prevalence was only increased after exclusion of HPV16-positive cases (OR(MH) 4.3; 95% CI 1.6-11.6). These results suggest that HPV18 is mainly a risk factor for the development of adenocarcinoma whereas HPV16 is associated with both SCC and adenocarcinoma. [less ▲]

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See detailPhysical and chemical properties of pyropheophorbide)a-methyl ester in ethanol, phosphate buffer and aqueous dispersion of small unilamellar dimyristoyl-L-a-phosphatidylcholine vesicles
Delanaye, Lisiane; Bahri, Mohamed Ali ULiege; Tfibel, Francis et al

in Photochemical & Photobiological Sciences (2006), 5

The aggregation process of pyropheophorbide-a methyl ester (PPME), a second generation hotosensitizer, was investigated in various solvents. Absorption and fluorescence spectra showed that the ... [more ▼]

The aggregation process of pyropheophorbide-a methyl ester (PPME), a second generation hotosensitizer, was investigated in various solvents. Absorption and fluorescence spectra showed that the photosensitizer was under a monomeric form in ethanol as well as in dimyristoyl-L-α-phosphatidylcholine liposomes while it was strongly aggregated in phosphate buffer. A quantitative determination of reactive oxygen species production by PPME in these solvents has been undertaken by electron spin resonance associated with spin trapping technique and absorption spectroscopy. In phosphate buffer, both electron spin resonance and absorption measurements led to the conclusion that singlet oxygen production was not detectable while hydroxyl radical production was very weak. In liposomes and ethanol, singlet oxygen and hydroxyl radical production increased highly; the singlet oxygen quantum yield was determined to be 0.2 in ethanol and 0.13 in liposomes. The hydroxyl radical production origin was also investigated. Singlet oxygen was formed from PPME triplet state deactivation in presence of oxygen. Indeed, the triplet state formation quantum yield of PPME was found to be about 0.23 in ethanol, 0.15 in liposomes (too small to be measured in PBS). [less ▲]

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See detailLes effets indésirables des interventions 'psychothérapeutiques' en psychotraumatologie
Mormont, Christian ULiege

in Revue Francophone du Stress et du Trauma (2006), 6(2), 114-116

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See detailRelationship between haptoglobin, serum amyloid A, and clinical status in a survey of dairy herds during a 6-month period
Humblet, Marie-France ULiege; Guyot, Hugues ULiege; Boudry, Benjamin et al

in Veterinary Clinical Pathology (2006), 35(2), 188-193

Haptoglobin and serum amyloid A are major acute phase proteins in cattle. Dairy cattle often develop pathologic conditions in the peripartum period; acute phase proteins may be useful in their diagnosis ... [more ▼]

Haptoglobin and serum amyloid A are major acute phase proteins in cattle. Dairy cattle often develop pathologic conditions in the peripartum period; acute phase proteins may be useful in their diagnosis. Objectives: The purpose of this study was to compare the accuracy of serum haptoglobin (Hp) and serum amyloid A (SAA) concentrations with clinical health status for diagnosing disease during the peripartum period in dairy cattle. Methods: Dairy cows from 4 herds were evaluated every 15 days over a 6-month period. Health status was determined by thorough clinical examination. Haptoglobin and SAA concentrations were measured in serum using validated methods and the results were classifed as positive or negative based on defined cutoff points. Disease prevalence, sensitivity, and specificity were compared using clinical examination as the gold standard. Results: A total of 1896 samples from 158 cows were analyzed. Significant increases in mean Hp and SAA concentrations were observed in the week following parturition in both primiparous and multiparous cows, although high interindividual variability was observed. Both Hp and SAA had low sensitivity but higher specificity in determining disease status compared with clinical examination. Increased concentrations of Hp and SAAwere found in ,10% of samples from clinically healthy cows, except in the week after parturition. Conclusions: Haptoglobin and serum amyloid A should be used with caution as markers of inflammation in the week after calving. Poor sensitivity in other postpartum periods could be related to the higher incidence of chronic (vs acute) inflammation. Haptoglobin may be appropriate for routine screening, but further work needs to be done to assess its value as an indicator of herd health. [less ▲]

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See detailHuman papillomavirus type-specific 18-month risk of high-grade cervical intraepithelial neoplasia in women with a normal or borderline/mildly dyskaryotic smear.
Berkhof, Johannes; Bulkmans, Nicole W. J.; Bleeker, Maaike C. G. et al

in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2006), 15(7), 1268-73

INTRODUCTION: High-risk human papillomavirus (hrHPV) DNA testing is an increasingly used instrument in cervical cancer prevention along cervical cytology. The inclusion of hrHPV testing in cervical ... [more ▼]

INTRODUCTION: High-risk human papillomavirus (hrHPV) DNA testing is an increasingly used instrument in cervical cancer prevention along cervical cytology. The inclusion of hrHPV testing in cervical screening requires efficient management as many hrHPV infections are transient. We investigated the potential value of hrHPV genotyping in normal and borderline/mildly dyskaryotic (BMD) smears. MATERIALS AND METHODS: From a screening population of 44,102 women in the Netherlands, we included hrHPV-positive women with a normal or BMD smear. We assessed the type-specific 18-month risk of high-grade cervical intraepithelial neoplasia (CIN). RESULTS: In hrHPV-positive women, 18-month risk of CIN grade 3 or invasive cancer (> or =CIN3) was 6% [95% confidence interval (95% CI), 4-9] after normal cytology and 20% (95% CI, 16-25) after BMD. If positive for HPV16, > or =CIN3 risks were 14% (95% CI, 9-21) and 37% (95% CI, 28-48), respectively. In the subset of hrHPV-positive women without HPV16, HPV18 was associated with an increased risk of high-grade CIN after normal cytology and HPV31 and HPV33 were associated with an increased risk, particularly after BMD. HPV16 and HPV18 were also associated with an increased risk of high-grade CIN in women with an hrHPV-positive normal baseline smear and a repeat normal smear at 6 months. DISCUSSION: HrHPV-positive women without type 16, 18, 31, or 33 had a relatively low risk of high-grade CIN. Among women with baseline normal cytology and among women with a baseline and repeat normal smear, HPV16/18-positive women showed an increased risk of high-grade CIN. This warrants more aggressive management of HPV16/18-positive women compared with other hrHPV-positive women. [less ▲]

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See detail51. Telmisartan Plus HCTZ vs. Amlodipine Plus HCTZ in older patients with systolic hypertension : results from a large ambulatory blood pressure monitoring study
Neldam, Steen; Edwards, Colin; The ATHOS study group et al

in American Journal of Geriatric Cardiology (2006), 15

Systolic hypertension often requires combination therapy. Few data exist comparing angiotensin receptor blocker plus diuretic therapy with other combinations in older patients. In a prospective ... [more ▼]

Systolic hypertension often requires combination therapy. Few data exist comparing angiotensin receptor blocker plus diuretic therapy with other combinations in older patients. In a prospective, randomized, open-label, blinded-end point trial, patients (≥60 years of age) with predominantly systolic hypertension received telmisartan 40–80 mg or amlodipine 5–10 mg for 8 weeks, before the addition of hydrochlorothiazide (HCTZ) 12.5 mg for a further 6 weeks. Twenty-four-hour ambulatory blood pressure monitoring showed that telmisartan plus HCTZ (n =448) and amlodipine plus HCTZ (n =424) changed systolic blood pressure for the last 6 hours of the dosing interval by −18.3 and −17.4 mm Hg, respectively (p =0.2520). Over the 24-hour period, telmisartan plus HCTZ was superior (−19.3 and −17.2 mm Hg, respectively; p =0.001) and provided higher systolic control rates (65.9% and 58.3%, respectively; p =0.0175). Adverse events (41.2% and 53.7%, respectively) and discontinuations (5.0% and 11.3%, respectively) were lower (p<0.0001) with telmisartan than with amlodipine, mainly due to peripheral edema (1.2% and 24.3%, respectively). [less ▲]

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See detailThe Two Body Problem in Rotating Reference Frames
Condurache, D.; Martinusi, Vladimir ULiege

in Bulletin of the Polytechnic Institute of Jasi. Section Mathematics, Theoretical Mechanics, Physics = Buletinul Institutului Politehnic din Iaşi. Secţia Matematica, Mecanica Teoretica, Fizica (2006), LII(LVI)(3-4), 27-46

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See detailInter-session, inter-tester and inter-site reproducibility of isometric trunk muscle strength measurements
Demoulin, Christophe ULiege; Grosdent, Stéphanie ULiege; Debois, I. et al

in Isokinetics & Exercise Science (2006), 14(4), 317-325

The purpose of this study was to investigate the inter-session, inter-tester and inter-site reproducibility of trunk muscle strength scores in flexion, extension, lateral flexion and rotation. Ten healthy ... [more ▼]

The purpose of this study was to investigate the inter-session, inter-tester and inter-site reproducibility of trunk muscle strength scores in flexion, extension, lateral flexion and rotation. Ten healthy students were tested on four apparatus with a 7-10 day break between sessions. The first two sessions were identical while the other two differed either by the tester or by the site. Furthermore, 10 patients with chronic low back dysfunction (CLBD) were assessed with the four apparatus, once only. For all tests, CV ranged from 3.4% to 7.6% and from 3.9% to 8.1% in the inter-session and inter-tester studies, respectively (p > 0.05 except for inter-session reproducibility of trunk flexor strength). Peak torque (PT) was more variable from site to site with a CV ranging from 4.2% to 12.7%, particularly in extension and left lateral flexion (p < 0.05). No statistically significant difference in the strength ratios (flexion/extension, right/left lateral-flexion and right/left rotation) were found between sessions or testers (4.9% < CV < 9.7%). The inter-site reproducibility of ratios was lower. Comparison between the CLBD patients and the healthy subjects with regard to PT normalized to body weight indicated significantly decreased performance for the former except for flexion and rotation scores in males. We conclude that in the case of healthy subjects, inter-session and inter-tester trunk strength measurements derived from these devices are reproducible. The low inter-site reproducibility suggests that caution should be exercised when interpreting findings originating from different sites. The lower extension strength scores in CLBD patients test lends some validity to the system. However, further studies focusing on reproducibility and validity of this system in CLBD patients are critical before any conclusion regarding their clinical viability may be drawn. [less ▲]

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See detailRetour sur le Conseil Wallon de l'Economie Sociale: quel héritage?
Defourny, Jacques ULiege

in SAW-B Analyses (2006), 7

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See detailMechanochemistry: targeted delivery of single molecules
Duwez, Anne-Sophie ULiege; Cuenot, Stéphane; Jérôme, Christine ULiege et al

in Nature Nanotechnology (2006), 1

The use of scanning probe microscopy-based techniques to manipulate single molecules(1) and deliver them in a precisely controlled manner to a specific target represents a significant nanotechnological ... [more ▼]

The use of scanning probe microscopy-based techniques to manipulate single molecules(1) and deliver them in a precisely controlled manner to a specific target represents a significant nanotechnological challenge(2,3). The ultimate physical limit in the design and fabrication of organic surfaces can be reached using this approach. Here we show that the atomic force microscope (AFM), which has been used extensively to investigate the stretching of individual molecules(4-12), can deliver and immobilize single molecules, one at a time, on a surface. Reactive polymer molecules, attached at one end to an AFM tip, are brought into contact with a modified silicon substrate to which they become linked by a chemical reaction. When the AFM tip is pulled away from the surface, the resulting mechanical force causes the weakest bond - the one between the tip and polymer - to break. This process transfers the polymer molecule to the substrate where it can be modified by further chemical reactions. [less ▲]

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See detailBilateral complete discoid medial meniscus combined with posterior cyst formation
Franceschi, F.; Longo, U. G.; Ruzzini, L. et al

in Knee Surgery, Sports Traumatology, Arthroscopy (2006), 15

Bilateral discoid medial menisci is an extremely rare condition of the knee and it can be associated to other pathological findings, including anterior portion cyst formation. We report on the clinical ... [more ▼]

Bilateral discoid medial menisci is an extremely rare condition of the knee and it can be associated to other pathological findings, including anterior portion cyst formation. We report on the clinical features, radiographic findings, treatment and results of one patient who presented a bilateral medial discoid meniscus combined with posterior portion cyst of the left knee. To the best of the author's knowledge, this is the first case of bilateral medial discoid meniscus associated with posterior portion cyst formation. [less ▲]

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See detailLa saga des inhibiteurs des histone-desacetylases: de la TSA au SAHA
Peixoto, Paul ULiege; Lansiaux, Amelie

in Bulletin du Cancer (2006), 93(1), 27-36

Histone-deacetylase inhibitors (HDCACi) represent a new class of antitumor agents currently in clinical development. They target a family of enzymes which catalyse histone acetylation modifications, in ... [more ▼]

Histone-deacetylase inhibitors (HDCACi) represent a new class of antitumor agents currently in clinical development. They target a family of enzymes which catalyse histone acetylation modifications, in particular for histones H2A, H2B, H3 and H4. These proteins stabilize the nucleosome core, fundamental unity of chromatin which represents the first level of DNA nuclear compaction. The balance of histone acetylation is maintained by histone-acetyltransferases (HAT) and histone-deacetylases (HDAC) which play an important role in gene transcription. Alterations of HDACs were identified in tumor cells and contribute to the massive perturbations of gene expression in numerous tumors. HDAC inhibition leads to differentiation, cell cycle arrest and apoptosis in tumor cells. HDACi efficiently prevent tumor growth in a variety of in vivo preclinical models. Several structurally distinct classes of HDACi have entered in clinical trials and a significant antitumor activity was reported in several cases. However, a better understanding of the biological effects of this class of enzymes is mandatory for the successful development of these new antitumoral agents. In this review, are exposed the main drug candidates in clinical development. In the near future, it will be interesting to define direct relationships between specific inhibition of one or several HDAC and the subsequent HDAC-dependent antitumor effects to define a new generation of specific histone-deacetylase inhibitors. [less ▲]

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See detailA Short Solution to the Keplerian Ballistic Problem Using the Velocity Hodograph
Condurache, D.; Martinusi, Vladimir ULiege

in Bulletin of the Polytechnic Institute of Jasi. Section Mathematics, Theoretical Mechanics, Physics = Buletinul Institutului Politehnic din Iaşi. Secţia Matematica, Mecanica Teoretica, Fizica (2006), LII(LVI)(1-2), 47-54

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See detailBrain response to one's own name in vegetative state, minimally conscious state and locked-in syndrome
Perrin, F.; Schnakers, Caroline ULiege; Schabus, M. et al

in Archives of Neurology (2006), 63

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See detailLe cas clinique du mois. Le syndrome de Pierre-Marie Bamberger
Rouers, A.; Radermecker, Maurice ULiege; Duysinx, Bernard ULiege et al

in Revue Médicale de Liège (2006), 61(3), 142-4

We report the case of a lung adenocarcinoma revealed by clubbing and secondary hypertrophic osteoarthropathy or Pierre-Marie Bamberger syndrome.

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See detailThe N-Terminal Juxtamembranous Domain Of Kcnq1 Is Critical For Channel Surface Expression - Implications In The Romano-Ward Lqt1 Syndrome
Dahimene, S.; Alcolea, S.; Naud, P. et al

in Circulation Research (2006), 99(10), 1076-83

arrhythmias in newborn children and adolescents but the cellular mechanisms involved in this dramatic issue remain, however, to be discovered. Here, we analyzed the trafficking of a series of N-terminal ... [more ▼]

arrhythmias in newborn children and adolescents but the cellular mechanisms involved in this dramatic issue remain, however, to be discovered. Here, we analyzed the trafficking of a series of N-terminal truncation mutants and identified a critical trafficking motif of KCNQ1. This determinant is located in the juxtamembranous region preceding the first transmembrane domain of the protein. Three mutations (Y111C, L114P and P117L) implicated in inherited Romano-Ward LQT1 syndrome, are embedded within this domain. Reexpression studies in both COS-7 cells and cardiomyocytes showed that the mutant proteins fail to exit the endoplasmic reticulum. KCNQ1 subunits harboring Y111C or L114P exert a dominant negative effect on the wild-type KCNQ1 subunit by preventing plasma membrane trafficking of heteromultimeric channels. The P117L mutation had a less pronounced effect on the trafficking of heteromultimeric channels but altered the kinetics of the current. Furthermore, we showed that the trafficking determinant in KCNQ1 is structurally and functionally conserved in other KCNQ channels and constitutes a critical trafficking determinant of the KCNQ channel family. Computed structural predictions correlated the potential structural changes introduced by the mutations with impaired protein trafficking. In conclusion, our studies unveiled a new role of the N-terminus of KCNQ channels in their trafficking and its implication in severe forms of LQT1 syndrome. [less ▲]

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See detailThe lipopeptides mycosubtilin and surfactin enhance spreading of Bacillus subtilis strains by their surface-active properties.
Leclere, Valerie; Marti, Romain; Bechet, Max et al

in Archives of microbiology (2006), 186(6), 475-83

The colonizing behaviour and the pellicle formation of Bacillus subtilis strains producing different families of lipopeptides were evaluated under several cultural conditions. The pattern of lipopeptides ... [more ▼]

The colonizing behaviour and the pellicle formation of Bacillus subtilis strains producing different families of lipopeptides were evaluated under several cultural conditions. The pattern of lipopeptides produced determined the architecture of the colony on a swarming medium as well as the flotation and the thickness of the pellicle formed at the air/liquid interface. The overproduction of mycosubtilin, a lipopeptide of the iturin family, led to increased spreading but had no effect on pellicle formation. A physico-chemical approach was developed to gain an insight into the mode of action of the biosurfactants facilitating the colonization. A relationship between surface tension of the culture medium and spreading of a lipopeptide non-producing strain, B. subtilis 168, was established. Goniometry was used to highlight the modification of the in situ wettability in the area where spreading was enhanced. On a solid medium, co-cultures of a surfactin producing with other strains showed a diffusion ring of the surfactin around the colony. This ring characterized by a higher wettability favoured the propagation of other colonies. [less ▲]

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See detailLocomotor effects of ethanol and acetaldehyde after peripheral and intraventricular injections in Swiss and C57BL/6J mice
Tambour, Sophie ULiege; Didone, Vincent ULiege; Tirelli, Ezio ULiege et al

in Behavioural Brain Research (2006), 172(1), 145-154

Several studies have suggested that acetaldehyde, the first product of ethanol metabolism, is involved in the locomotor stimulant effects of ethanol in mice, although it has never been formally tested ... [more ▼]

Several studies have suggested that acetaldehyde, the first product of ethanol metabolism, is involved in the locomotor stimulant effects of ethanol in mice, although it has never been formally tested whether acetaldehyde injected directly into the brain of mice has stimulant properties. Recently, it was also shown in rats that both ethanol and acetaldehyde can induce opposite locomotor effects according to the route of administration. Whereas peripheral administrations of ethanol and acetaldehyde induced locomotor depressant effects, their infusions directly into the brain produced locomotor stimulation. The aim of the present study was to characterize in mice the locomotor effects of ethanol and acetaldehyde injected either peripherally by the intraperitoneal route or centrally into the brain ventricles. Additionally, the effects of ethanol and acetaldehyde were compared in two strains of mice known for their differential sensitivity to the locomotor effects of ethanol, namely Swiss and C57BL/6J mice. Ethanol induced a biphasic effect on locomotor activity in Swiss mice, with stimulant effects at low to moderate doses and depressant effects at higher doses. Such a profile of effects was observed whatever the route of administration, peripheral or central. In C57BL/6J mice, ethanol only induced monophasic depressant effects. In this mouse strain, no evidence of the stimulant effects of ethanol was found after either an i.p. or an i.c.v. administration of ethanol. In contrast to ethanol, acetaldehyde yielded only depressant effects in both strains of mice after both peripheral and central administrations. These results indicate that the route of administration does not alter the locomotor effects of ethanol and acetaldehyde in mice. Additionally, the present study shows that the stimulant properties of acetaldehyde, even after direct infusion into the brain, are not as obvious as previously speculated. [less ▲]

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See detailRodents biodiversity and associated infections in Southeast Asia
Hugot, Jean Pierre; Suputtamongkol, Yupin; Jittapalapong, Sathaporn et al

in Genetics in Infectious Diseases (2006), 8(4), 19

We are currently involved in a Franco-Thai program devolved to a multidisciplinary investigation of Muridae rodents (‘‘mice and rats''), their parasites and the pathogens that they may carry and/or ... [more ▼]

We are currently involved in a Franco-Thai program devolved to a multidisciplinary investigation of Muridae rodents (‘‘mice and rats''), their parasites and the pathogens that they may carry and/or transmit to human, with a better understanding of diseases emergence as an ultimate goal. In such a context, pathogens circulation in the wild is a complex but pivotal phenomenon which requires a continuum of scientific approaches to be accurately apprehended. In particular, a rigorously comparative study is mandatory in order to take into account the interactions between parasites, wild and domestic hosts (uncluding human) and their environment. This is the reason why we rely on both concepts and techniques from a wide range of disciplines including taxonomy, cytogenetics, phylogenetics, phylogeography, population genetics, ecology, geography as well as modeling. With the following objectives. Objective 1: To precisely identify and characterize the rodent species acting as reservoirs, and to document their ecology, geographic distribution as well as the genetic structure of their populations. To assess parasite and pathogen diversity in relation to their associated rodent hosts. To provide cophylogenies and co-phylogeographies in order to enlight the evolutionary relationships of hosts and parasites. Objective 2: To map and correlate the observed rodents distributions with their species-specific environmental landscapes in order to extrapolate their potential ‘‘real'' range and to anticipate their future distributions in relation to landscape modifications. Objective 3: Computing epidemiological databases. Crosschecking field data and GIS data. Definition and standardization of a risk-scale. Finalization of maps of risks and distributions. Atlas of Thai Muridae. Reference collection of Thai Muridae. Education and training of students. Following the listing of the objectives, we expose the first results of our studies and we sketch future projects. [less ▲]

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See detailA simple method for detecting and adjusting meta-analyses for publication Bias
Richy, F.; Reginster, Jean-Yves ULiege

in Internet Journal of Epidemiology (2006), 3(2),

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See detailCross-calibration functions for soil CO2 efflux measurement systems
Ngao, Jerome; Longdoz, Bernard ULiege; Perrin, Dominique ULiege et al

in Annals of Forest Science : a Multidisciplinary and International Journal (2006), 63(5), 477-484

Different soil CO2 efflux measurement systems and methodologies were used to estimate the annual soil respiration of different forest sites. To allow comparison between these annual values, this study ... [more ▼]

Different soil CO2 efflux measurement systems and methodologies were used to estimate the annual soil respiration of different forest sites. To allow comparison between these annual values, this study aimed to cross-calibrate five soil CO2 efflux (RS) closed dynamic chamber systems, and compare the in situ measurement methodologies. We first assessed the impact of the measurement methodology on RS by studying the effects of three parameters: record duration, time lag before starting to record and the mode of chamber-soil contact (use of collars or insertion of the chambers into the soil). Secondly, we directly compared systems with identical methodology during field measurements on three forest sites. We observed a significant influence of the chamber-soil contact mode (no impact of the record duration and duration before starting to record). Measurements obtained by insertion led to significantly higher estimates of RS than those obtained using collars (up to 28%). Our inter-comparison showed that deviations existing between in situ measurements performed with the different systems were partly systematic and could be corrected using simple linear equations. Measurements of pressure difference between the inside and the outside of soil chambers allowed explaining a part of the observed deviations between systems. Finally, we assessed the influence of the cross-calibration equations on annual respiration of two beech forest soils. [less ▲]

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See detailL'affaire Total Fina: quand le pragmatisme prend le pas sur la réalité intellectuelle
Kettels, Aurélie ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2006), 34(34), 1503-1509

Note relative à l'arrêt 104/2006 prononcé le 21 juin 2006 par la Cour constitutionnelle dans l'affaire dite "Total Fina" : application ratione temporis d'une disposition relative à la compétence des ... [more ▼]

Note relative à l'arrêt 104/2006 prononcé le 21 juin 2006 par la Cour constitutionnelle dans l'affaire dite "Total Fina" : application ratione temporis d'une disposition relative à la compétence des juridictions belges pour connaître d'infractions au droit international humanitaire. [less ▲]

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See detailA new species of Jonesiobryum (Bryopsida : Rhachitheciaceae) from Uganda
Fischer, E.; Killmann, D.; Sérusiaux, Emmanuel ULiege

in Journal of Bryology (2006), 28(3), 177-181

Jonesiobryum dumboi is described as a new moss species from Uganda. It differs from its congeners by possessing more broadly obovate leaves and a costa that ends well below the apex. The species is only ... [more ▼]

Jonesiobryum dumboi is described as a new moss species from Uganda. It differs from its congeners by possessing more broadly obovate leaves and a costa that ends well below the apex. The species is only known from the type locality where it was collected on branches in the canopy. [less ▲]

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See detailStochastic models to study the impact of mixing on a fed-batch culture of Saccharomyces cerevisiae.
Delvigne, Frank ULiege; Lejeune, Annick ULiege; Destain, Jacqueline ULiege et al

in Biotechnology Progress (2006), 22(1), 259-69

The mechanisms of interaction between microorganisms and their environment in a stirred bioreactor can be modeled by a stochastic approach. The procedure comprises two submodels: a classical stochastic ... [more ▼]

The mechanisms of interaction between microorganisms and their environment in a stirred bioreactor can be modeled by a stochastic approach. The procedure comprises two submodels: a classical stochastic model for the microbial cell circulation and a Markov chain model for the concentration gradient calculus. The advantage lies in the fact that the core of each submodel, i.e., the transition matrix (which contains the probabilities to shift from a perfectly mixed compartment to another in the bioreactor representation), is identical for the two cases. That means that both the particle circulation and fluid mixing process can be analyzed by use of the same modeling basis. This assumption has been validated by performing inert tracer (NaCl) and stained yeast cells dispersion experiments that have shown good agreement with simulation results. The stochastic model has been used to define a characteristic concentration profile experienced by the microorganisms during a fermentation test performed in a scale-down reactor. The concentration profiles obtained in this way can explain the scale-down effect in the case of a Saccharomyces cerevisiae fed-batch process. The simulation results are analyzed in order to give some explanations about the effect of the substrate fluctuation dynamics on S. cerevisiae. [less ▲]

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See detailLe syndrome de Prader Willi: intérêt d'une prise en charge pluridisciplinaire
Salmon, C.; Gaillez, Stephanie ULiege; Pieltain, Catherine ULiege et al

in Revue Médicale de Liège (2006), 61(7-8, Jul-Aug), 593-599

Prader Willi syndrome can be viewed as a physiopathological model of obesity. Such patients deserve specific management, preferably in a multidisciplinary setting. The paper reports on 6 patients followed ... [more ▼]

Prader Willi syndrome can be viewed as a physiopathological model of obesity. Such patients deserve specific management, preferably in a multidisciplinary setting. The paper reports on 6 patients followed in the paediatric endocrine service at the University of Liege. [less ▲]

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See detailL’adoption par des couples homosexuels dans les cas internationaux: Une perspective réaliste?
Collienne, Fleur ULiege

in Revue Trimestrielle de Droit Familial (2006)

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See detailScheler critique de Husserl. Esquisse d'une perspective non transcendantale au coeur du projet phénoménologique.
Frère, Bruno ULiege

in Philosophie (2006), 91

Nous nous proposons de retracer les divergences qui caractérisent les philosophies de Husserl et Scheler en partant du principe que c’est bel et bien dans le contexte de la naissance de la phénoménologie ... [more ▼]

Nous nous proposons de retracer les divergences qui caractérisent les philosophies de Husserl et Scheler en partant du principe que c’est bel et bien dans le contexte de la naissance de la phénoménologie qu’elles doivent être toutes deux envisagées. Nous commencerons par retracer le tournant transcendantal de Husserl avant de voir combien ce même tournant poussera Scheler à prendre ses distances avec lui pour évoluer un temps aux côtés de Heidegger. Ensuite, nous tâcherons de montrer combien leurs ontologies respectives les mènent l’un et l’autre à des conceptions de la réduction eidétique radicalement différentes. Enfin, en guise de conclusion, c’est l’issue même de cette réduction et, plus généralement, de la phénoménologie de Scheler que nous tenterons de dégager. Accordons d’emblée qu’il est effectivement difficile de faire l’impasse sur la dimension personnaliste de l’œuvre de Scheler. Néanmoins, nous allons ici nous atteler à une stricte mise à l’épreuve de sa pensée en tâchant de l’évacuer. Cette restriction dans l’analyse nous permettra de mettre en relief une tentative de « pensée » phénoménologique à notre sens judicieuse. Peut-elle alors conserver sa cohérence si on lui concède une échappée « hors phénoménologie » ? [less ▲]

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See detailLe Concours Jean Pictet – Édition 2006 : Une première participation pleine de promesses de l’Université de Liège
Collienne, Fleur ULiege; Jullien, Gaëlle ULiege; Guerra, Vincent ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2006)

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See detailFréquence et importance du charriage dans les rivières du massif ardennais
Houbrechts, Geoffrey ULiege; Hallot, Eric ULiege; Gob, F. et al

in Géographie physique et Quaternaire (2006), 60(3), 247-258

Le transport de la charge de fond de plusieurs rivières du massif ardennais (Belgique) a été analysé grâce à différentes techniques de marquage de galets (peinture, charge métallique, émetteurs radio ... [more ▼]

Le transport de la charge de fond de plusieurs rivières du massif ardennais (Belgique) a été analysé grâce à différentes techniques de marquage de galets (peinture, charge métallique, émetteurs radio). Ces rivières possèdent un bassin versant dont la taille est comprise entre 0,3 et 2700 km². Les observations ont permis de mettre en évidence le débit à partir duquel débute le charriage. Pour des rivières importantes (bassin versant supérieur à 500 km²), cette mise en mouvement se produit pour des débits légèrement inférieurs au débit à plein bord (0,7 à 1 Qb), débits qui se présentent en moyenne 5 à 11 jours par an. Dans les rivières ardennaises de taille intermédiaire (bassin versant compris entre 100 et 500 km²), on constate que le charriage débute pour un débit proche de 0,5 fois le débit à plein bord, avec des récurrences de l’ordre de 0,3 an et une durée de charriage variant entre 8 et 12 jours par an. Dans les rivières de dimension modeste (bassin versant inférieur à 100 km²), il apparaît que la mise en mouvement de la charge de fond se produit pour des débits compris entre 0,5 et 0,8 Qb, mais la récurrence de ces débits est relativement faible et le charriage peut se produire jusqu’à 20 jours par an. Par ailleurs, le transport solide par charriage a été évalué à l'aide de pièges à sédiments dans les rivières de petite dimension (bassin versant inférieur à 10 km²) ; il est relativement peu important dans les bassins forestiers (de l'ordre de 0,5 t.km-².an-1), notamment en raison de la multiplication des embâcles végétaux qui accroissent la rugosité et provoquent une forte dissipation d'énergie. Dans les rivières plus importantes, le transport solide a été estimé entre 0,4 et 2,5 t.km-².an-1 grâce à l'analyse des quantités curées systématiquement aux mêmes sites et à la réalisation de levés topographiques de contrôle. Nous avons ensuite analysé l’évolution des quantités charriées en fonction de la puissance spécifique au plein bord développée par ces rivières. La relation établie sur la base de ces données a permis de mettre en évidence le déficit en sédiments de certaines rivières ainsi que plusieurs facteurs influençant le charriage. [less ▲]

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See detailElastase-induced pulmonary emphysema in rats: comparison of computed density and microscopic morphometry.
Onclinx, Cecile; De Maertelaer, Viviane; Gustin, Pascal ULiege et al

in Radiology (2006), 241(3), 763-70

PURPOSE: To prospectively compare computed tomographic (CT) quantification of pulmonary emphysema in elastase-treated rats with morphometry and to evaluate the information yielded by CT quantification and ... [more ▼]

PURPOSE: To prospectively compare computed tomographic (CT) quantification of pulmonary emphysema in elastase-treated rats with morphometry and to evaluate the information yielded by CT quantification and pulmonary function tests. MATERIALS AND METHODS: This study was approved by the local committee on care and use of animals in research. Thirty-six animals were used. Emphysema was produced by means of one or two tracheal injections of 300 IU of elastase, 8 weeks apart, in seven and 12 rats, respectively. As a control group, 10 rats received an injection of normal saline. The dynamic resistance, dynamic compliance, and static compliance were measured. CT was performed with 1-mm section thickness and 3-mm intervals. Relative areas of lung with attenuation coefficients lower than nine chosen thresholds (from -900 to -980 HU) and eight percentiles (from 1st to 18th percentiles) of the distribution of attenuation coefficients were compared with measurements of alveoli size--that is, mean interwall distance (MIWD) and mean perimeter per field (MP). Correlations between data obtained with thresholds and percentiles and MIWD and MP were investigated by means of Spearman coefficients (r(s)). Values of pulmonary function tests, most appropriate relative area threshold, and percentile were investigated by means of stepwise multiple regressions. RESULTS: For thresholds, relative surface area with attenuation coefficients less than -940 HU (RA(940)) showed the strongest correlations with findings at microscopy (r(s) = 0.676, P < .001 for MIWD; r(s) = -0.720, P < .001 for MP). For percentiles, the 3rd percentile showed the strongest correlations (r(s) = -0.647, P < .001 for MIWD; r(s) = 0.701, P < .001 for MP). Dynamic compliance and RA(940) or 3rd percentile were complementary for predicting microscopic measurements. CONCLUSION: In rats, RA(940) and the 3rd percentile reflect the extent of elastase-induced pulmonary emphysema and are complementary to dynamic compliance to predict microscopic extent. [less ▲]

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See detailBespreking HvJ 15 juli 2004
Peeters, Bart ULiege

in Rechtskundig Weekblad (2006)

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See detailTowards A Standardized Processing Of Net Ecosystem Exchange Measured With Eddy Covariance Technique: Algorithms And Uncertainty Estimation
Papale, D.; Reichstein, M.; Aubinet, Marc ULiege et al

in Biogeosciences (2006), 3(4),

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See detailA nonlinear time-domain homogenization technique for laminated iron cores in three-dimensional finite-element models
Gyselinck, Johan; V Sabariego, Ruth ULiege; Dular, Patrick ULiege

in IEEE Transactions on Magnetics (2006), 42(4), 763-766

The authors present a novel nonlinear homogenization technique for laminated iron cores in three-dimensional (3-D) finite-element (FE) models of electromagnetic devices. The technique takes into account ... [more ▼]

The authors present a novel nonlinear homogenization technique for laminated iron cores in three-dimensional (3-D) finite-element (FE) models of electromagnetic devices. The technique takes into account the eddy current effects in the stacked core without the need of modeling all laminations separately. A nonlinear constitutive magnetic law is considered. The system of nonlinear algebraic equations obtained after time discretization is solved by means of the Newton-Raphson scheme. By way of validation, the method is applied to a 3-D FE model of a laminated ring core with toroidal coil. [less ▲]

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See detailOn the application and interpretation of Keeling plots in paleo climate research - Deciphering δ 13C of atmospheric CO 2 measured in ice cores
Köhler, Peter; Fischer, Hubertus; Schmitt, Jochen et al

in Biogeosciences (2006), 3(4), 539-556

The Keeling plot analysis is an interpretation method widely used in terrestrial carbon cycle research to quantify exchange processes of carbon between terrestrial reservoirs and the atmosphere. Here, we ... [more ▼]

The Keeling plot analysis is an interpretation method widely used in terrestrial carbon cycle research to quantify exchange processes of carbon between terrestrial reservoirs and the atmosphere. Here, we analyse measured data sets and artificial time series of the partial pressure of atmospheric carbon dioxide (pCO(2)) and of delta C-13 of CO2 over industrial and glacial/interglacial time scales and investigate to what extent the Keeling plot methodology can be applied to longer time scales. The artificial time series are simulation results of the global carbon cycle box model BICYCLE. The signals recorded in ice cores caused by abrupt terrestrial carbon uptake or release loose information due to air mixing in the firn before bubble enclosure and limited sampling frequency. Carbon uptake by the ocean cannot longer be neglected for less abrupt changes as occurring during glacial cycles. We introduce an equation for the calculation of long-term changes in the isotopic signature of atmospheric CO2 caused by an injection of terrestrial carbon to the atmosphere, in which the ocean is introduced as third reservoir. This is a paleo extension of the two reservoir mass balance equations of the Keeling plot approach. It gives an explanation for the bias between the isotopic signature of the terrestrial release and the signature deduced with the Keeling plot approach for long-term processes, in which the oceanic reservoir cannot be neglected. These deduced isotopic signatures are similar (-8.6 parts per thousand) for steady state analyses of long-term changes in the terrestrial and marine biosphere which both perturb the atmospheric carbon reservoir. They are more positive than the delta C-13 signals of the sources, e.g. the terrestrial carbon pools themselves (similar to -25 parts per thousand). A distinction of specific processes acting on the global carbon cycle from the Keeling plot approach is not straightforward. In general, processes related to biogenic fixation or release of carbon have lower y-intercepts in the Keeling plot than changes in physical processes, however in many case they are indistinguishable (e.g. ocean circulation from biogenic carbon fixation). [less ▲]

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See detailComment j'explore...une chéilite.
Goffin, Véronique ULiege; Blaise, G.; Henry, Frédérique ULiege et al

in Revue Médicale de Liège (2006), 61(11), 780-2

A cheilitis is an inflammatory disease confined to the lips. Several origins are recognized. Their nature is often different in children and adults. Some are spongiotic due to irritation or allergic ... [more ▼]

A cheilitis is an inflammatory disease confined to the lips. Several origins are recognized. Their nature is often different in children and adults. Some are spongiotic due to irritation or allergic reaction. Other lesions are keratotic and can evolve to leucoplasia and epidermoid carcinoma. [less ▲]

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See detailSkin capacitance imaging, a new technique for investigating the skin surface.
Leveque, Jean-Luc; Xhauflaire, Emmanuelle ULiege; Pierard, Gérald ULiege

in European Journal of Dermatology (2006), 16(5), 500-6

Thanks to the recently introduced silicone image sensor technology, skin capacitance imaging has now been made possible. The dedicated device is called SkinChip. This method is easy to handle and provides ... [more ▼]

Thanks to the recently introduced silicone image sensor technology, skin capacitance imaging has now been made possible. The dedicated device is called SkinChip. This method is easy to handle and provides information about the skin microrelief, the level of stratum corneum hydration and the sweat gland activity. The apparatus sees and measures these parameters with a 50 microm resolution. A series of conditions have been explored using skin capacitance imaging. This review summarizes relevant findings about regional variability on the body, changes occurring with ageing, effects of a hydrating formulation, reactivity kinetics of corneocytes to surfactants, acne and skin pores characteristics, as well as hyperkeratotic dermatoses and tumours. [less ▲]

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See detailPlankton dynamics controlled by hydrodynamic processes near a submarine canyon off NW corsican coast: A numerical modelling study
Skliris, Nikolaos ULiege; Djenidi, Salim ULiege

in Continental Shelf Research (2006), 26(11), 1336-1358

A three-dimensional (3D) non-linear high-resolution hydrodynamic model coupled to a coastal plankton ecosystem model is used to estimate the impact of hydrodynamic processes on the evolution of the spring ... [more ▼]

A three-dimensional (3D) non-linear high-resolution hydrodynamic model coupled to a coastal plankton ecosystem model is used to estimate the impact of hydrodynamic processes on the evolution of the spring phytoplankton bloom in the vicinity of a submarine canyon. Model results for the plankton distribution showed a clear 3D character around and in the canyon, with large horizontal and vertical gradients, induced by the hydrodynamic constraints. Phytoplankton concentrations were significantly larger all along the slope domain with maximum values obtained over the canyon. Upwelling of deep water rich in nitrate takes place both upstream (with respect to the current direction normal to the central axis of the canyon) and downstream of the canyon enhancing primary production. As phytoplankton-rich water enters into the western part of the canyon it is downwelled and trapped by the cyclonic circulation leading to accumulation of phytoplankton biomass there. The effect of wind events was to induce an upward nitrate flux into the upper layer through vertical turbulent diffusion, allowing the start of a short-live phytoplankton bloom. Maximum surface nitrate concentrations were found along the slope and particularly upstream and downstream of the canyon just after the wind stopped. Enhanced turbulent diffusion combined with upwelling motion in these areas resulted in larger upward nitrate transports, further enhancing primary production. (c) 2006 Elsevier Ltd. All rights reserved. [less ▲]

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See detailBlood pressure reduction with olmesartan in mild-to-moderate essential hypertension: a planned interim analsis of an open label sub-study in German patients
Barrios, Vivencio; Böhm, Michael; Boccanelli, Alessandro et al

in Current Medical Research & Opinion (2006), 22(7), 1375-1380

Objective : To present the baseline characteristics and open-label treatment phase results for German patients in OLMEBEST, a European, multinational, partially randomized, partially double-blind study in ... [more ▼]

Objective : To present the baseline characteristics and open-label treatment phase results for German patients in OLMEBEST, a European, multinational, partially randomized, partially double-blind study in patients with mild-to-moderate essential hypertension. Research design an methods: after a 2-week placebo run-in, patients received olmesartan 20 mg for 8 weeks. Controlled patients (mean sitting diastolic blood pressure [sDBP] < 90 mmHg) continued on olmesartan 20 mg/day for a further 4 weeks. Non-controlled patients (sDBP > 90 mmHg) were randomized to olmesartan 40 mg/day or olmesartan 20 mg/day plus 12.5 mg hydrochlorothiazide for 4 weeks. Of 823 patients included, 558 continued olmesartan 20 mg treatment and 228 patients were randomized to olmesartan 40 mg/day or combination therapy. Efficacy variables included the change from baseline in mean sitting DBP and systolic blood pressure [sDBP] at Week 8 (and Week 12 for controlled patients), and the proportion of controlled patients and responders (mean sDBP < 90 mmHg or improvement of > 10 mmHg from baseline at Week 8). Results: After 8 Weeks of olmesartan medoxomil 20 mg, mean reduction from baseline in sDBP was 11.8 mmHg and in sSBP was 17.1 mmHg. In controlled patients continuing open-label olmesartan medoxomil 20 mg, mean reduction from baseline at 12 weeks in sDBP was 14.9 mmHg and in sSBP was 20.1 mmHg. At Week 8, the response rate was 76% and the control rate was 30.9% of patients experienced and adverse event, and the majority of these events were judged by the investigators to be mild. Conclusion:l Olmesartan medoxomil monotherapy at the recommended dosage of 20 mg once daily is effective and well tolerated in patients with mild-to-moderate hypertension. [less ▲]

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See detailQualitative and quantitative evaluation of equine respiratory mechanics by impulse oscillometry
Van Erck, Emmanuelle; Votion, Dominique ULiege; Art, Tatiana ULiege et al

in Equine Veterinary Journal (2006), 38(1), 52-58

Reasons for performing study: The long- established conventional reference technique (CRT) for measuring respiratory mechanics in horses lacks sensitivity and there is a need for further refinement in new ... [more ▼]

Reasons for performing study: The long- established conventional reference technique (CRT) for measuring respiratory mechanics in horses lacks sensitivity and there is a need for further refinement in new technology, such as the impulse oscillometry system (IOS). Objectives: To evaluate the potential use of the IOS as a clinical respiratory function test and compare it to the current CRT in horses suffering from common upper and lower airway dysfunctions. Methods: Six healthy horses were tested before and after induction of a unilateral nasal obstruction (UNO) or transient left laryngeal hemiplegia. (LLH). Six heaves-affected horses were tested in clinical remission and during a heaves crisis, before and after nebulisation of cumulative doses of a bronchodilator therapy (ipratropium bromide; IPB). Results: As opposed to the CRT, the IOS was able to detect partial upper airway obstruction (UAO) caused by UNO or LLH in resting horses, without differentiating both conditions. Upper airway obstruction caused an upward shift of resistance (R-rs) from 5 to 35 Hz without altering reactance (X-rs). As for the CRT, IOS respiratory parameters measured in heaves-affected horses in crisis differed significantly from values measured during remission. The difference in frequency-dependent behaviour of R-rs and X-rs allowed discrimination between upper and lower airway obstructions. Bronchodilator treatment induced significant dose-dependent changes in X-rs at 5 and 10 Hz, from the first dose. Total pulmonary resistance (R-L) and R-rs at 5 Hz were affected from the second dose and displayed similar sensitivity. Although post treatment R-L values were comparable to remission, R-rs and X-rs remained significantly different, characterising persistent peripheral obstruction. Conclusions: The IOS was more sensitive than the CRT in detecting partial UAO in resting horses and persistent post treatment peripheral dysfunction in heaves-affected horses. The IOS is a sensitive test that provides graded quantitative and qualitative information on disease-induced respiratory dysfunctions as well as on treatment efficiency in horses. Potential relevance: The IOS could represent a practical and sensitive alternative respiratory function test for routine clinical investigations of common airway obstructive diseases and therapy in horses. [less ▲]

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See detailThromboprophylaxis in microsurgery
Lecoq, Jean-Pierre ULiege; Senard, Marc ULiege; Hartstein, Gary ULiege et al

in Acta Chirurgica Belgica (2006), 106(2), 158-64

Microsurgical free tissue transfer has become a gold standard in a wide range of clinical situations. Thrombosis at the anastomotic site is not only the most common cause of failure of microsurgical ... [more ▼]

Microsurgical free tissue transfer has become a gold standard in a wide range of clinical situations. Thrombosis at the anastomotic site is not only the most common cause of failure of microsurgical operations, but it is also one of the factors resulting in microcirculatory intravascular thrombosis in free flaps. All conditions of thrombus formation, defined by Virchow in 1856, are encountered in free flap surgery. This literature review concerns the problem of thromboprophylaxis in microsurgery. All citations published this last ten years (1996-2005) concerning this problem are noted. Data are confronted with other specialties, particularly vascular surgery, or with large retrospective studies. Protocol used in our institution is presented at the end of this lecture. [less ▲]

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See detailBespreking HvJ 18 november 2004
Peeters, Bart ULiege

in Rechtskundig Weekblad (2006)

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See detailRadiographic and ultrasonographic findings of emphysematous cystitis in four nondiabetic female dogs
Petite, A.; Busoni, Valeria ULiege; Heinen, Marie-Pierre ULiege et al

in Veterinary Radiology & Ultrasound (2006), 47(1), 90-93

The urinary bladder of four dogs with emphysematous cystitis was assessed radiographically. Ultrasonography was also performed using a 7.5-MHz microconvex probe in dorsal recumbency and in a standing ... [more ▼]

The urinary bladder of four dogs with emphysematous cystitis was assessed radiographically. Ultrasonography was also performed using a 7.5-MHz microconvex probe in dorsal recumbency and in a standing position. Ultrasonographically there were bright echoes and reverberations typical of gas in all dogs. This was entrapped in the bladder wall as it appeared in the same location in recumbent and standing positions. Bladder size was reduced and bladder content was echogenic in all dogs. In only one out of the four dogs was a gas stripe seen in the bladder on radiographs. Proteus mirahilis was isolated from the urine of all patients. Diabetes was ruled out on the basis of urine and blood analysis. A small amount of gas can be difficult to detect on radiographs. Ultrasonography appears to be a more sensitive technique for detection of gas within the bladder at an early stage of emphysematous cystitis. Prevalence of emphysematous cystitis may be underestimated if only radiographs are made. [less ▲]

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See detailEffect of excavation induced fractures on radionuclide migration through the Boom Clay (Belgium)
Huysmans, Marijke; Berckmans, Arne; Dassargues, Alain ULiege

in Applied Clay Science (2006), 33(3-4), 207-218

In Belgium, the Boom Clay is being evaluated as a potential host formation for the disposal of high-level nuclear waste. In order to investigate this option, an underground research facility composed of ... [more ▼]

In Belgium, the Boom Clay is being evaluated as a potential host formation for the disposal of high-level nuclear waste. In order to investigate this option, an underground research facility composed of two access shafts and 200m of galleries was excavated. Excavation induced fractures were observed in a zone of approximately 1 m around the galleries. In this study, the potential effect of these fractures on radionuclide migration in the Boom Clay is investigated. Therefore, a hydrogeological model of the clay is built with a radionuclide source in the middle of the clay layer surrounded by different fracture configurations. Two types of fracture configurations are inserted in the model. The first type of fracture properties is drawn stochastically from the probability distributions of the properties of the fractures observed around previously excavated galleries. These fracture patterns are considered to be realistic although in this study it is conservatively assumed that no self-sealing occurs. The model is run for a large number of stochastically drawn fracture configurations and the results are compared to a model without fractures. These calculations show that the radionuclide fluxes through the clay are not significantly influenced by these fractures. For the second type of fracture configurations, the fracture properties are varied over a much larger range. Hypothetical fractures with much higher values of fracture extent, aperture, dip and frequency than observed are modeled, With these hypothetical fracture configurations, the critical values of the fracture parameters are determined that must be exceeded to have a significant effect on the radionuclide fluxes through the clay. These calculations show that the extent of the fractured zone has the largest effect on radionuclide migration. The other fracture parameters (aperture, spacing and dip) have a limited effect on the radionuclide fluxes. To obtain a total radionuclide flux through the lower clay boundary that is respectively 10%, 50% and 100% larger than without a fractured zone, the extent of the hypothetical fractured zone should be respectively 27.97 m, 43.86 m and 46.92 m. Such fractures are not expected to be generated by mechanical excavation in the Boom Clay. The obtained critical extent values of the hypothetical fractures are a factor 30 to 40 higher than the measured values of the extent of the excavation disturbed zone. These calculations thus indicate that it is very unlikely that the extent of the fractured zone around the galleries will be large enough to have a significant effect on the radionuclide fluxes through the Boom Clay. This conclusion is further supported by the conservative assumption that no self-sealing occurs. These calculations can function as a preliminary robustness test in ongoing safety analysis studies. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailRechtspraakoverzicht BTW 2004-2005
Peeters, Bart ULiege; Van de velde, Elly; Putzeys, Wim et al

in Algemeen Fiscaal Tijdschrift (2006)

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See detailSocial relationships in a free-ranging group of bonnet macaques in Tamil Nadu, India
Mehu, Marc; Huynen, Marie-Claude ULiege; Agoramoorthy, G.

in Primate Report (2006)

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See detailImplicit memory during isoflurane anesthesia - Reply
Iselin-Chaves, Irène A.; Willems, Sylvie ULiege

in Anesthesiology (2006), 105(2), 430-430

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See detailAction du maître de l'ouvrage contre le sous-traitant: le débat n'est pas clos. Note sous C.A., 28 juin 2006
Kohl, Benoît ULiege

in Entreprise et le Droit (L') = Tijdschrift voor Aannemingsrecht (2006)

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See detailEarly boost and slow consolidation in motor skill learning
Hotermans, C.; Peigneux, Philippe ULiege; Maertens De Noordhout, Alain ULiege et al

in Learning & Memory (Cold Spring Harbor, N.Y.) (2006), 13(5, Sep-Oct), 580-583

Motorskill learning is a dynamic process that continues covertly after training has ended and eventually leads to delayed increments in performance. Current theories Suggest that this off-line improvement ... [more ▼]

Motorskill learning is a dynamic process that continues covertly after training has ended and eventually leads to delayed increments in performance. Current theories Suggest that this off-line improvement takes time and appears only after several hours. Here we show an early transient and short-lived boost in performance, emerging as early as 5-30 min after training but no longer observed 4 h later. This early boost is predictive of the performance achieved 48 h later, Suggesting its functional relevance for memory processes. [less ▲]

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See detailTeaching communication and stress management skills to junior physicians dealing with cancer patients: a Belgian Interuniversity Curriculum
Bragard, Isabelle ULiege; Razavi, Darius; Marchal, Serge et al

in Supportive Care in Cancer (2006), 14(5), 454-461

Background: Ineffective physicians' communication skills have detrimental consequences for patients and their relatives, such as insufficient detection of psychological disturbances, dissatisfaction with ... [more ▼]

Background: Ineffective physicians' communication skills have detrimental consequences for patients and their relatives, such as insufficient detection of psychological disturbances, dissatisfaction with care, poor compliance, and increased risks of litigation for malpractice. These ineffective communication skills also contribute to everyday stress, lack of job satisfaction, and burnout among physicians. Literature shows that communication skills training programs may significantly improve physicians' key communication skills, contributing to improvements in patients' satisfaction with care and physicians' professional satisfaction. This paper describes a Belgian Interuniversity Curriculum (BIC) theoretical roots, principles, and techniques developed for junior physicians specializing in various disciplines dealing with cancer patients. Curriculum description: The 40-h training focuses on two domains: stress management skills and communication skills with cancer patients and their relatives. The teaching method is learner-centered and includes a cognitive, behavioral, and affective approach. The cognitive approach aims to improve physicians' knowledge and skills on the two domains cited. The behavioral approach offers learners the opportunity to practice these appropriate skills through practical exercises and role plays. The affective approach allows participants to express attitudes and feelings that communicating about difficult issues evoke. Such an intensive course seems to be necessary to facilitate the transfer of learned skills in clinical practice. Conclusions: The BIC is the first attempt to bring together a stress management training course and a communication training course that could lead not only to communication skills improvements but also to burnout prevention. [less ▲]

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See detailBaryon resonances in large N(c) QCD
Matagne, Nicolas; Stancu, Floarea ULiege

in Bled Workshops in Physics (2006), 7(1), 61-66

The baryon spectra are discussed in the context of the $1/N_c$ expansion approach, with emphasis on mixed symmetric states. The contributions of the spin dependent terms as a function of the excitation ... [more ▼]

The baryon spectra are discussed in the context of the $1/N_c$ expansion approach, with emphasis on mixed symmetric states. The contributions of the spin dependent terms as a function of the excitation energy are shown explicitly. At large energies these contributions are expected to vanish. [less ▲]

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See detailInhibition of ceramide-redox signaling pathway blocks glomerular injury in hyperhomocysteinemic rats.
Yi, F.; Zhang, A. Y.; Li, N. et al

in Kidney International (2006), 70(1), 88-96

Ceramide-activated NAD(P)H oxidase has been reported to participate in homocysteine (Hcys)-induced abnormal metabolism of the extracellular matrix (ECM) in rat glomerular mesangial cells. However, it ... [more ▼]

Ceramide-activated NAD(P)H oxidase has been reported to participate in homocysteine (Hcys)-induced abnormal metabolism of the extracellular matrix (ECM) in rat glomerular mesangial cells. However, it remains unknown whether this ceramide-redox signaling pathway contributes to glomerular injury induced by hyperhomocysteinemia (hHcys) in vivo. The present study was designed to address this question, defining the role of ceramide and activated NAD(P)H oxidase in the development of hHcys-induced glomerular injury. Uninephrectomized Sprague-Dawley rats were fed a folate-free diet for 8 weeks to produce hHcys and the de novo ceramide synthesis inhibitor myriocin or the NAD(P)H oxidase inhibitor apocynin was administrated. Rats with folate-free diet significantly increased plasma Hcys levels, renal ceramide levels, and NAD(P)H oxidase activity accompanied by marked glomerular injury. Treatment of rats with myriocin significantly reduced ceramide levels and improved glomerular injury, as shown by decreased urinary albumin excretion and reduced glomerular damage index. ECM components changed towards to normal levels with decreased tissue inhibitor of metalloproteinase-1 and increased matrix metalloproteinase-1 activity. NAD(P)H oxidase activity and Rac GTPase activity were reduced by 69 and 66%, respectively. In rats treated with apocynin, similar beneficial effects in protecting glomeruli from hHcys-induced injury were observed. These results support the view that de novo ceramide production is involved in Hcys-induced NAD(P)H oxidase activity in the kidney of hHcys rats and indicate the important role of ceramide-mediated redox signaling in hHcys-induced glomerular injury in rats. [less ▲]

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See detailLa loi du 21 février 2005 sur la médiation
Caprasse, Olivier ULiege

in Cahier du Juriste = Cahier van de Jurist (2006)

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See detailImpact of low-frequency transcranial magnetic stimulation on brain automatic information processing - A mismatch negativity study
Laloyaux, Olivier ULiege; Ansseau, Marc ULiege; Hansenne, Michel ULiege

in Journal of Psychophysiology (2006), 20(4), 267-275

Repetitive transcranial magnetic stimulation (rTMS) is considered a powerful method for the study of the relationships between cortical activity and-cognitive processes. Previous ERPs studies' that ... [more ▼]

Repetitive transcranial magnetic stimulation (rTMS) is considered a powerful method for the study of the relationships between cortical activity and-cognitive processes. Previous ERPs studies' that focused on P300 response have shown that inhibitory/excitatory effects on prefrontal cortex (PFC), induced by low- and high-frequency rTMS, were able to modulate controlled but not automatic information processing. The present study assessed the impact of inhibition over left and right PFC induced by rTMS on mismatch negativity (MMN), which is known to represent automatic cerebral processes for detecting change. Auditory MMN was recorded in 20 subjects before and after application of left and right PFC 1-Hz rTMS for 15 min. MMN was also recorded before and after a sham-occipital 1-Hz rTMS as control condition. Results showed that 1-Hz rTMS induced no modification to either MMN latency or amplitude. In addition, N100 and P200 components to the frequent tones were not affected by rTMS. These results are consistent with previous findings showing that rTMS; over both PFC is unable to disrupt automatic information processing. However, since two sites were stimulated in the present-study, no definite conclusions about the inability of rTMS to disrupt automatic processing can be made. [less ▲]

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See detailTime series of the partial pressure of carbon dioxide (2001 2004) and preliminary inorganic carbon budget in the Scheldt plume (Belgian coast waters)
Schiettecatte, Laure-Sophie; Gazeau, Frédéric; Van der Zee, Claar et al

in Geochemistry, Geophysics, Geosystems (G3) (2006), 7(Q06009),

A 4-year time series (2001–2004) of the partial pressure of CO2 (pCO2) and air-sea CO2 fluxes is reported in the Scheldt estuarine plume. This system is oversaturated in CO2 with respect to the atmosphere ... [more ▼]

A 4-year time series (2001–2004) of the partial pressure of CO2 (pCO2) and air-sea CO2 fluxes is reported in the Scheldt estuarine plume. This system is oversaturated in CO2 with respect to the atmosphere, except during the spring phytoplanktonic bloom, and acts as a net source of CO2 to the atmosphere of 0.7 mol C m 2 yr 1 that represents 7 to 27% of the inner Scheldt estuary CO2 emission. Results also highlight that a high spatial and temporal coverage of the surface pCO2 in coastal ecosystems is crucial for reliable estimations of air-sea CO2 fluxes. The seasonal variations of pCO2 seem to be more dominated by biological activities (photosynthesis/respiration) than by temperature change. A stochiometrically linked C/P mass balance budget failed to provide net ecosystem production estimates consistent with the pCO2 dynamics in this area. It is hypothesized that this discrepancy is related to physiological characteristics of the dominant phytoplanktonic species (Phaeocystis sp.) within the studied area. On the basis of a preliminary dissolved inorganic carbon input/output budget, the annual emission of CO2 toward the atmosphere seems to be largely due to the outgassing of the inputs of CO2 from the inner Scheldt estuary, rather than due to organic carbon degradation. [less ▲]

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See detailL'approche belge pour mieux prévenir les risques psychosociaux en général et le harcèlement psychologique en particulier.
Hansez, Isabelle ULiege; Faulx, Daniel ULiege; Mahy, Aude

in Santé, Société et Solidarité (2006), 2

La législation est un levier important de la mise en place de mesures de prévention des risques professionnels. La directive européenne n°89/391/CEE donne l’impulsion à une législation commune au sein de ... [more ▼]

La législation est un levier important de la mise en place de mesures de prévention des risques professionnels. La directive européenne n°89/391/CEE donne l’impulsion à une législation commune au sein de l’Union en matière de prévention des risques professionnels et de protection de la sécurité et de la santé des travailleurs. Chaque pays membre a la responsabilité de transposer cette directive dans sa législation nationale. Aujourd’hui, tous les états membres ne sont pas arrivés au même stade maturation dans leur politique de prévention des risques psychosociaux. En Belgique, l’évolution de la législation en matière de santé et de sécurité au travail s’est caractérisée par un élargissement très marqué de la notion de sécurité au travail vers celle de la santé, puis de bien-être au travail et enfin plus spécifiquement de violence, harcèlement moral ou sexuel au travail. La loi sur le bien-être au travail de 1996 laisse apparaître pour la première fois la notion de prévention des risques psychosociaux. Une convention collective de travail (la CCT 72 de 1999) porte plus spécifiquement sur la prévention du stress professionnel. Plus récemment, la loi sur la protection contre la violence, le harcèlement moral ou sexuel au travail a été votée en 2002. Le domaine couvert par cette loi a été ajouté aux domaines qui font partie de la notion de bien-être dans la loi de 1996 sur le bienêtre des travailleurs. Après la description de ces législations, ce papier présente les pratiques en matière de recherche et d’interventions dans les entreprises qui découlent directement de ces nouvelles dispositions légales. Enfin le recul, certes encore minime, de leur application alimente la réflexion sur les répercussion de ces pratiques en entreprise ou auprès des travailleurs. [less ▲]

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See detailLe groupe des « bisons adossés » de Lascaux : étude de la technique de l’artiste par analyse de pigments
Vignaud, Colette; Salomon, Hélène ULiege; Chalmin, Emilie et al

in Anthropologie (L') (2006)

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See detailHigh-sensitivity staining of proteins for one- and two-dimensional gel electrophoresis using post migration covalent staining with a ruthenium fluorophore.
Tokarski, Caroline; Cren-Olive, Cecile; Fillet, Marianne ULiege et al

in Electrophoresis (2006), 27(7), 1407-16

This paper describes the use of a ruthenium complex ((bis(2,2'-bipyridine)-4'-methyl-4-carboxybipyridine-ruthenium-N-succidimyl ester-bis(hexafluorophosphate), abbreviated below as ASCQ_Ru) commercially ... [more ▼]

This paper describes the use of a ruthenium complex ((bis(2,2'-bipyridine)-4'-methyl-4-carboxybipyridine-ruthenium-N-succidimyl ester-bis(hexafluorophosphate), abbreviated below as ASCQ_Ru) commercially available and chemically pure. This new ruthenium complex ASCQ_Ru brings an activated ester, allowing the selective acylation of amino acid side chain amines for the post migration staining of proteins separated in 1-DE and 2-DE. The protocol used is a simple three-step protocol fixing the proteins in the gel, staining and then washing, as no lengthy destaining step is required. First the critical staining step was optimized. Although in solution the best described pH for acylating proteins with this reagent is phosphate buffer at pH 7.0, we found that best medium for in-gel staining is unbuffered ACN/water solution (20/80 v/v). The two other steps are less critical and classical conditions are satisfactory: fixing with 7% acetic acid/10% ethanol solution and washing four times for 10 min with water. Sensitivity tests were performed using 1-DE on protein molecular weight markers. We obtained a higher sensitivity than SYPRO Ruby with a detection limit of 80 pg of protein per well. However, contrary to SYPRO Ruby, ASCQ_Ru exhibits a logarithmic dependency on the amount of protein. The dynamic range is similar to SYPRO Ruby and is estimated between three and four orders of magnitude. Finally, the efficiency of the post migration ASCQ_Ru staining for 2-D gel separation is demonstrated on the whole protein extract from human colon carcinoma cells lines HCT 116. ASCQ_Ru gave the highest number of spot detected compared to other common stains Colloidal CBB, SYPRO Ruby and Deep Purple. [less ▲]

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See detailA general discontinuous Galerkin method for finite hyperelasticity. Formulation and numerical applications
Noels, Ludovic ULiege; Radovitzky, Raúl

in International Journal for Numerical Methods in Engineering (2006), 68(1), 6497

A discontinuous Galerkin formulation of the boundary value problem of finite-deformation elasticity is presented. The primary purpose is to establish a discontinuous Galerkin framework for large ... [more ▼]

A discontinuous Galerkin formulation of the boundary value problem of finite-deformation elasticity is presented. The primary purpose is to establish a discontinuous Galerkin framework for large deformations of solids in the context of statics and simple material behaviour with a view toward further developments involving behaviour or models where the DG concept can show its superiority compared to the continuous formulation. The method is based on a general Hu-Washizu-de Veubeke functional allowing for displacement and stress discontinuities in the domain interior. It is shown that this approach naturally leads to the formulation of average stress fluxes at interelement boundaries in a finite element implementation. The consistency and linearized stability of the method in the non-linear range as well as its convergence rate are proven. An implementation in three dimensions is developed, showing that the proposed method can be integrated into conventional finite element codes in a straightforward manner. In order to demonstrate the versatility, accuracy and robustness of the method examples of application and convergence studies in three dimensions are provided. Copyright (c) 2006 John Wiley [less ▲]

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See detailDe quelques ‘retours soninké’ aux différents âges de la vie: Circulations entre la France et le Mali
Razy, Elodie ULiege

in Journal des Anthropologues (2006), 106-107

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See detailStorms späte Novelle „John Riew‘“ oder: Wie alles gut wurde.
Gerrekens, Louis ULiege; Pastor, Eckart ULiege

in Schriften der Theodor-Storm-Gesellschaft (2006), 55

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See detailMeasuring the extent of linkage disequilibrium in commercial pig populations
Harmegnies, N.; Farnir, Frédéric ULiege; DAVIN, Fabienne ULiege et al

in Animal Genetics (2006), 37(3), 225-231

To evaluate the extent of linkage disequilibrium in domestic pigs, we genotyped 33 and 44 unrelated individuals from two commercial populations for 29 and five microsatellite markers located on ... [more ▼]

To evaluate the extent of linkage disequilibrium in domestic pigs, we genotyped 33 and 44 unrelated individuals from two commercial populations for 29 and five microsatellite markers located on chromosomes 15 and 2 respectively. A high proportion of marker pairs up to 40 cM apart exhibited significant linkage disequilibrium in both populations. Pair-wise r(2) values averaged between 0.15 and 0.50 (depending on chromosome and population) for markers < 1 cM apart and declined to values of 0.05 for more distant syntenic markers. Our results suggest that both populations underwent a bottleneck approximately 20 generations ago, which reduced the effective population size from thousands to < 200 animals. [less ▲]

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See detailQualite de vie, emollients et agents hydratants.
Xhauflaire, Emmanuelle ULiege; Haubrechts, C.; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2006), 61(4), 233-6

So-called dry skin is a quite common and annoying condition. This skin may affect individuals that are otherwise healthy. It may be particularly severe and unpleasant in cases of ichthyosis, atopic ... [more ▼]

So-called dry skin is a quite common and annoying condition. This skin may affect individuals that are otherwise healthy. It may be particularly severe and unpleasant in cases of ichthyosis, atopic dermatitis or psoriasis. The inductive effects of the environment must not be ignored. Emollients and hydrating agents for the stratum corneum can help relieve the clinical manifestations. [less ▲]

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See detailSome genetic and biochemical aspects of myoclonus
Grisar, Thierry ULiege; de Nijs, Laurence ULiege; Chanas, G. et al

in Neurophysiologie Clinique = Clinical Neurophysiology (2006), 36(5-6, Sep-Dec), 271-279

Can a gene defect be responsible for the occurrence in an individual, at a particular age, of such a muscle twitch followed by relaxation called: "myoclonus" and defined as sudden, brief, shock-like ... [more ▼]

Can a gene defect be responsible for the occurrence in an individual, at a particular age, of such a muscle twitch followed by relaxation called: "myoclonus" and defined as sudden, brief, shock-like movements? Genetic defects could indeed determine a subsequent cascade of molecular events (caused by abnormal encoded proteins) that would produce new aberrant cellular relationships in a particular area of the CNS leading to re-builded "myoclonogenic" neuronal networks. This can be illustrated reviewing some inherited neurological entities that are characterized by a predominant myoclonic picture and among which a clear gene defect has been identified. In the second part of this chapter, we will also propose a new point of view on how some structural genes could, under certain conditions, when altered, produced idiopathic generalized epilepsy with myoclonic jerks, taking juvenile myoclonic epilepsy (JME) and the myoclonin (EFHC-1) gene as examples. (c) 2007 Elsevier Masson SAS. All rights reserved. [less ▲]

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See detailDirect evidence for ferroelectric polar distortion in ultrathin lead titanate perovskite films
Despont, L.; Koitzsch, C.; Clerc, F. et al

in Physical Review. B, Condensed Matter and Materials Physics (2006), 73

X-ray photoelectron diffraction is used to directly probe the intracell polar atomic distortion and tetragonality associated with ferroelectricity in ultrathin epitaxial PbTiO3 films. Our measurements ... [more ▼]

X-ray photoelectron diffraction is used to directly probe the intracell polar atomic distortion and tetragonality associated with ferroelectricity in ultrathin epitaxial PbTiO3 films. Our measurements, combined with ab initio calculations, unambiguously demonstrate noncentrosymmetry in films a few unit cells thick, imply that films as thin as three unit cells still preserve a ferroelectric polar distortion, and also show that there is no thick paraelectric dead layer at the surface. [less ▲]

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See detailStrontium ranelate for preventing and treating postmenopausal osteoporosis
O'Donnell, S.; Cranney, A.; Wells, G. A. et al

in Cochrane Database of Systematic Reviews (Online) (2006), 18(CD00), 5326

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See detailOptimal accumulation in an endogenous growth setting with human capital
Docquier, Frédéric; Paddison, Olivier; Pestieau, Pierre ULiege

in Journal of Economic theory (2006), 134(1), 361-378

This paper considers a three-overlapping-generations model of endogenous growth wherein human capital is the engine of growth. It first contrasts the laissez-faire and the optimal solutions Three possible ... [more ▼]

This paper considers a three-overlapping-generations model of endogenous growth wherein human capital is the engine of growth. It first contrasts the laissez-faire and the optimal solutions Three possible accumulation regimes are distinguished. Then it discusses a standard set of tax-transfer instruments that allow for decentralization of the social optimum. Within the limits of our model, the rationale for the standard pattern of intergenerational transfers (the working-aged financing the education of the young and the pension of the old) is seriously questioned. On pure efficiency grounds, the case for generous public pensions is rather weak. (c) 2006 Elsevier Inc. All rights reserved. [less ▲]

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See detailNon-infusional vs intravenous consolidation chemotherapy in eldery patients with acute myeloid leukemia : final results of th EORTC-GIMAMA AML-13 randomized phase III trial
Jehn, U.; Suciu, S.; Thomas, X. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2006), 20

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