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See detailBaelo Claudia dans l'Antiquité tardive: L'occupation du secteur sud-est du forum entre les IIIe et VIe siècles
Brassous, Laurent; Deru, Xavier ULiege; Rodríguez Gutiérrez, Oliva et al

in Melanges de la Casa de Velazquez (2017), 47(1), 167-200

Les recherches archéologiques conduites au sud-est du forum de la ville romaine de Baelo claudia ont permis de mettre au jour au-dessus du secteur monumental, plusieurs phases de transformation, d’abandon ... [more ▼]

Les recherches archéologiques conduites au sud-est du forum de la ville romaine de Baelo claudia ont permis de mettre au jour au-dessus du secteur monumental, plusieurs phases de transformation, d’abandon et de réoccupation entre les IIIe et VIe s. Les structures découvertes ainsi que le nombreux mobilier qui leur était associé (monnaies, céramique, verre, métal, faune, etc.) fournissent un éclairage nouveau sur l’histoire et la nature de l’agglomération dans l’antiquité tardive, qui entre la fin du IVe s. et son abandon définitif au VIe s. ressemble moins à une ville qu’à un gros village. [less ▲]

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See detailMicrofossils from the late Mesoproterozoic – early Neoproterozoic Atar/El Mreïti Group, Taoudeni Basin, Mauritania, northwestern Africa
Beghin, Jérémie ULiege; Storme, Jean-Yves; Blanpied, Christian et al

in Precambrian Research (2017), 291

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See detailUsefulness of multi-breed models in genetic evaluation of direct and maternal calving ease in Holstein and Belgian Blue Walloon purebreds and crossbreds
Vanderick, Sylvie ULiege; Gillon, Alain; Glorieux, Géry et al

in Livestock Science (2017), 198

The objective of this study was to verify the feasibility of a joint genetic evaluation system for calving ease trait of Belgian Blue (BBB) and Holstein (HOL) Walloon cattle based on data of purebred and ... [more ▼]

The objective of this study was to verify the feasibility of a joint genetic evaluation system for calving ease trait of Belgian Blue (BBB) and Holstein (HOL) Walloon cattle based on data of purebred and crossbred animals. Variance components and derived genetic parameters for purebred BBB and HOL animals were estimated by using single-breed linear animal models. This analysis showed clear genetic differences between breeds. Estimates of direct and maternal heritabilities (± standard error) were 0.34 (±0.02) and 0.09 (±0.01) for BBB, respectively, but only 0.09 (±0.01) and 0.04 (±0.01) for HOL, respectively. Moreover, a significant negative genetic correlation between direct and maternal effects was obtained in both breeds: −0.46 (±0.04) for BBB and −0.29 (±0.11) for HOL. Variance components and derived genetic parameters for purebred BBB and HOL and crossbred BBB ×× HOL cattle were then estimated by using two multi-breed linear animal models: a multi-breed model based on a random regression test-day model (Model MBV), and a multi-breed model based on the random regression multi-breed model (Model MBSM). Both multi-breed models use different functions of breed proportions as random regressions, thereby enabling modelling different additive effects according to animal's breed composition. The main difference between these models is the way in which relationships between breeds are accounted for in the genetic (co)variance structure. Genetic parameters differed between single-breed and multi-breed analysis, but are similar to the literature. For BBB, estimates of direct and maternal heritabilities (±SE) were 0.45 (±0.07) and 0.08 (±0.01) by using Model MBV, and 0.45 (±0.08) and 0.09 (±0.02) for Model MBSM, respectively. For HOL, these estimates were 0.18 (±0.04) and 0.05 (±0.01) using Model MBV, and 0.16 (±0.04) and 0.05 (±0.01) for Model MBSM, respectively. Reliability gains (up to 25%) indicated that the use of crossbred data in the multi-breed models had a positive influence on the estimation of genetic merit of purebred animals. A slight re-ranking of purebred sires and maternal grandsires was observed between single-breed and multi-breed models. Moreover, both multi-breed models can be considered as quasi-equivalent models because they performed almost equally well with respect to MSE and correlations, for purebred and crossbred animals. [less ▲]

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See detailAn investigation into the fraction of particle accelerators among colliding-wind binaries. Towards an extension of the catalogue
De Becker, Michaël ULiege; Benaglia, Paula; Romero, Gustavo E. et al

in Astronomy and Astrophysics (2017), 600

Particle-accelerating colliding-wind binaries (PACWBs) are multiple systems made of early-type stars able to accelerate particles up to relativistic velocities. The relativistic particles can interact ... [more ▼]

Particle-accelerating colliding-wind binaries (PACWBs) are multiple systems made of early-type stars able to accelerate particles up to relativistic velocities. The relativistic particles can interact with different fields (magnetic or radiation) in the colliding-wind region and produce non-thermal emission. In many cases, non-thermal synchrotron radiation might be observable and thus constitute an indicator of the existence of a relativistic particle population in these multiple systems. To date, the catalogue of PACWBs includes about 40 objects spread over many stellar types and evolutionary stages, with no clear trend pointing to privileged subclasses of objects likely to accelerate particles. This paper aims at discussing critically some criteria for selecting new candidates among massive binaries. The subsequent search for non-thermal radiation in these objects is expected to lead to new detections of particle accelerators. On the basis of this discussion, some broad ideas for observation strategies are formulated. At this stage of the investigation of PACWBs, there is no clear reason to consider particle acceleration in massive binaries as an anomaly or even as a rare phenomenon. We therefore consider that several PACWBs will be detected in the forthcoming years, essentially using sensitive radio interferometers which are capable of measuring synchrotron emission from colliding-wind binaries. Prospects for high-energy detections are also briefly addressed. [less ▲]

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See detailSiblings and the coming out process: a comparative case study
Haxhe, Stéphanie ULiege; Cerezo, Alison; Bergfeld, Jeanette et al

in Journal of Homosexuality (2017), 64

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See detailVitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults: research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO)
Cianferotti, Luisella; Bertoldo, Francesco; Bischoff-Ferrari, Heike et al

in Endocrine (2017), 56(2), 245-61

Introduction Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided ... [more ▼]

Introduction Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. Purpose and Methods Members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis have reviewed the main evidence for possible proven benefits of vitamin D supplementation in adults at risk of or with overt chronic extra-skeletal diseases, providing recommendations and guidelines for future studies in this field. Results and conclusions Robust mechanistic evidence is available from in vitro studies and in vivo animal studies, usually employing cholecalciferol, calcidiol or calcitriol in pharmacologic rather than physiologic doses. Although many cross-sectional and prospective association studies in humans have shown that low 25-hydroxyvitamin D levels (i.e., <50 nmol/L) are consistently associated with chronic diseases, further strengthened by a dose-response relationship, several meta-analyses of clinical trials have shown contradictory results. Overall, large randomized controlled trials with sufficient doses of vitamin D are missing, and available small to moderate-size trials often included people with baseline levels of serum 25-hydroxyvitamin D levels >50 nmol/L, did not simultaneously assess multiple outcomes, and did not report overall safety (e.g., falls). Thus, no recommendations can be made to date for the use of vitamin D supplementation in general, parental compounds, or non-hypercalcemic vitamin D analogs in the prevention and treatment of extra-skeletal chronic diseases. Moreover, attainment of serum 25-hydroxyvitamin D levels well above the threshold desired for bone health cannot be recommended based on current evidence, since safety has yet to be confirmed. Finally, the promising findings from mechanistic studies, large cohort studies, and small clinical trials obtained for autoimmune diseases (including type 1 diabetes, multiple sclerosis, and systemic lupus erythematosus), cardiovascular disorders, and overall reduction in mortality require further confirmation. [less ▲]

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See detailOvertopping induced failure of non-cohesive, homogenous fluvial dikes
Rifai, Ismail ULiege; Erpicum, Sébastien ULiege; Archambeau, Pierre ULiege et al

in Water Resources Research (2017), 53(4), 33733386

Accurate predictions of breach characteristics are necessary to reliably estimate the outflow hydrograph and the resulting inundation close to fluvial dikes. Laboratory experiments on the breaching of ... [more ▼]

Accurate predictions of breach characteristics are necessary to reliably estimate the outflow hydrograph and the resulting inundation close to fluvial dikes. Laboratory experiments on the breaching of sand-filled fluvial dikes were performed, considering a flow parallel to the dike axis. The breach was triggered by overtopping of the dike crest. A detailed monitoring of the transient evolution of the breach geometry was conducted, providing key insights into the gradual and complex processes involved in fluvial dike failure. The breach develops in two phases: (1) the breach becomes gradually wider and deeper eroding on the downstream side along the main channel, and (2) breach widening controlled by side slope failures, continuing in the downstream direction only. Increasing the inflow discharge in the main channel, the breach formation time decreases significantly and the erosion occurs preferentially on the downstream side. The downstream boundary condition has a strong influence on the breach geometry and the resulting outflow hydrograph. [less ▲]

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See detail18-Fluoro-deoxyglucose uptake in inflammatory hepatic adenoma: A case report.
Liu, Willy; Delwaide, Jean ULiege; BLETARD, Noëlla ULiege et al

in World Journal of Hepatology (2017), 9(11), 562-566

Positron emission tomography computed tomography (PET-CT) using 18-Fluoro-deoxyglucose (18FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of 18FDG and ... [more ▼]

Positron emission tomography computed tomography (PET-CT) using 18-Fluoro-deoxyglucose (18FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of 18FDG and benign tumors do not usually behave in such a way. The authors report herein the case of a 38-year-old female patient with a past medical history of cervical intraepithelial neoplasia and pheochromocytoma, in whom a liver lesion had been detected with PET-CT. The tumor was laparoscopically resected and the diagnosis of inflammatory hepatic adenoma was confirmed. This is the first description of an inflammatory hepatic adenoma with an 18FDG up-take. [less ▲]

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See detailDéploiement de dispositifs numériques au sein de nouvelles formes d’organisation : de l’émergence à la stabilisation
Jemine, Grégory ULiege

in Sociologies Pratiques (2017), 34(1), 49-59

De plus en plus d’organisations du secteur des services s’équipent aujourd’hui de dispositifs numériques variés qui modifient les contextes et les contenus du travail. Ces outils sont présentés comme des ... [more ▼]

De plus en plus d’organisations du secteur des services s’équipent aujourd’hui de dispositifs numériques variés qui modifient les contextes et les contenus du travail. Ces outils sont présentés comme des ingrédients indispensables des modes managériales actuelles qui permettraient à divers dispositifs organisationnels promouvant la flexibilité et la mobilité de s’incarner. La présente contribution propose une étude des ressorts de l’émergence et de la stabilisation de ces dispositifs numériques qui émergent dans le cours de transformations organisationnelles. Nous montrons comment, dans une compagnie d’assurances, les dispositifs numériques sont mobilisés pour répondre à une volonté de « modernisation » de l’organisation et d’optimisation de l’espace de travail. [less ▲]

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See detailEtude comparative des profils de dissolution in vitro de quinine sulfate générique et princeps en utilisant la Chromatographie Liquide Haute Performance
Mbinze Kindenge, Jérémie ULiege; Diallo, Tediane; Yemoa, Loconon ULiege et al

in Médecine d'Afrique Noire (2017), 64

Introduction : La quinine est une molécule préconisée pour le traitement du paludisme dans les régions où les souches de P. falciparum sont polyrésistantes. Face à l’importante utilisation de ses ... [more ▼]

Introduction : La quinine est une molécule préconisée pour le traitement du paludisme dans les régions où les souches de P. falciparum sont polyrésistantes. Face à l’importante utilisation de ses médicaments génériques d’une part, et au fléau des médicaments de qualité inférieure d’autre part, il devient plus que nécessaire d’appuyer les données des tests physico-chimiques par celles de dissolution in vitro dont l’évaluation et la comparaison des cinétiques permettra de prédire le comportement in vivo du principe actif et par conséquent l’efficacité du médicament générique. L’objectif de la présente étude est de réaliser une étude comparative de la cinétique de dissolution d’un princeps et d’un générique à base de quinine comprimé 300 mg commercialisés à Kinshasa. Matériels et méthodes : L’étude a été réalisée en utilisant trois milieux de pH différents (1,2 - 4,5 - 6,8) tels que recommandés par l’Agence Européenne de Médicament et en se servant d’un appareil de dissolution, tandis que l’équipement de chromatographie liquide à haute performance couplée à un détecteur à barrette de diodes a été utilisé pour la quantification. La méthode statistique fit factor a été appliquée pour comparer les résultats de dosage de la quinine dans les trois milieux tout en ayant évalué le biais à différents temps de dissolution. Résultats : Les différents échantillons de médicaments générique et princeps ont été conformes quant à l’identification et au dosage de la quinine, par contre leurs cinétiques de dissolution étaient non similaires. Discussion : Ceci pourrait avoir une influence sur l’efficacité du produit générique et la sécurité des consommateurs, dénotant l’importance d’examiner les profils de dissolution des génériques avant toute autorisation de mise sur le marché plus particulièrement dans les pays en voie de développement. [less ▲]

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See detailLe Fichier écologique des essences, version 2.0
Petit, S.; Claessens, Hugues ULiege; Vincke, C. et al

in FORÊT.NATURE (2017), (143), 12-19

Après plus de 25 ans d’utilisation, le Fichier écologique des essences méritait une révision en profondeur. Il a été remis au goût du jour grâce à l’Accord-cadre de recherches et vulgarisation forestières ... [more ▼]

Après plus de 25 ans d’utilisation, le Fichier écologique des essences méritait une révision en profondeur. Il a été remis au goût du jour grâce à l’Accord-cadre de recherches et vulgarisation forestières et par les équipes de recherches de l’Ulg-GxABT et de l’UCL, avec l’appui de Forêt Wallonne. Fruit d’une collaboration entre chercheurs et gestionnaires de terrain, il repose sur un large travail de recherche bibliographique, adapté au contexte wallon grâce aux membres d’un groupe de travail composé de scientifiques et de forestiers. Il a évolué pour répondre aux attentes de la société et prône une forêt multifonctionnelle et résiliente face aux changements climatiques. Disponible sous format web, il facilite la prise en main par les utilisateurs et les guide vers la meilleure adaptation entre les essences et les stations, gage d’un écosystème pleinement fonctionnel, résilient et répondant aux besoins actuels de la société. [less ▲]

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See detailUse of cis-atracurium to maintain moderate neuromuscular blockade in experimental pigs
Tutunaru, Alexandru-Cosmin ULiege; Dupont, Julien ULiege; Serteyn, Didier ULiege et al

in Veterinary Anaesthesia & Analgesia (2017)

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See detailOut of the ground: two coexisting fossorial toad species differ in their emergence and movement patterns
Székely, Diana ULiege; Cogalniceanu, Dan; Székely, Paul et al

in Zoology (2017), 121

Understanding the way species with similar niches can coexist is a challenge in ecology.The niche partitioning hypothesis has received much support, positing that species can exploit available resources ... [more ▼]

Understanding the way species with similar niches can coexist is a challenge in ecology.The niche partitioning hypothesis has received much support, positing that species can exploit available resources in different ways. In the case of secretive species, behavioural mechanisms of partitioning are still poorly understood. This is especially true for fossorial frogs because individuals hide underground by day and are active only during the night. We investigated the nocturnal activity and tested the niche partitioning hypothesis in two syntopic fossorial spadefoot toads (Pelobates fuscus and P. syriacus) by examining interspecific variation in emergence from the soil. We employed a night vision recording system combined with video-tracking analyses in a replicated laboratory setting to quantify individual movement patterns, a procedure that has not been used until now to observe terrestrial amphibians. Most individuals appeared on the surface every night and returned to their original burrow (about 60% of the times), or dug a new one around morning. There was a large temporal overlap between the two species. However, P. syriacus was significantly more active than P. fuscus in terms of total distance covered and time spent moving, while P. fuscus individuals left their underground burrow more frequently than P. syriacus. Consequently, P. fuscus adopted more of a sit-and-wait behaviour compared to P. syriacus, and this could facilitate their coexistence. The use of night video-tracking technologies offered the advantage of individually tracking these secretive organisms during their nocturnal activity period and getting fine-grain data to understand their movement patterns. [less ▲]

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See detailHet Belgische interneringsbeleid als een voorbeeld van hybride bestuur
Pans, Maurice; Darcis, Coralie ULiege; Leys, Mark et al

in Tijdschrift voor Bestuurswetenschappen en Publiekrecht (2017), 4

Het domein van de zorg voor geïnterneerde personen kent internationaal een omslag. Naast de “criminalisering” van personen met een psychiatrische stoornis die criminele feiten begaan, ontwikkelen er zich ... [more ▼]

Het domein van de zorg voor geïnterneerde personen kent internationaal een omslag. Naast de “criminalisering” van personen met een psychiatrische stoornis die criminele feiten begaan, ontwikkelen er zich nieuwe visies en zorgperspectieven op de kwaliteit van leven en de re-integratie in de maatschappij van zowel personen met psychische kwetsbaarheid als geïnterneerde personen. Tot zeer recent werden geïnterneerde personen bijna exclusief benaderd als personen die misdaden of misdrijven hebben gepleegd waar ze door hun psychische stoornis niet voor verantwoordelijk konden worden gesteld. De onderliggende logica van de aanpak was sterk geënt op een model waarbij opsluiting en isolatie van de maatschappij centraal stonden omwille van misdaad. Geïnterneerde personen werden om die reden opgesloten in een gevangenissysteem volgens een justitiële benadering. Het behandelings- en zorgperspectief raakte hierbij ondergesneeuwd. De “criminalisering” van personen met psychische stoornissen heeft in België historisch geleid tot inadequate aanpak en begeleiding van deze groep patiënten. Meerdere veroordelingen van de Belgische Staat door het Europees Hof voor de Rechten van de Mens (EHRM), overvolle gevangenissen, het gebrek aan somatische en psychiatrische gezondheidszorg binnen gevangenissen en psychiatrische annexen en aanbevelingen van het Europees Comité voor de Preventie van Foltering en Onmenselijke of Vernederende Behandeling of Bestraffing (CPT) zijn directe aanleidingen voor het Masterplan Internering (juni 2016) en de wet van 5 mei 2014 betreffende de internering van personen . In deze bijdrage staan we stil bij het Masterplan Internering van 2016 en de nieuwe Interneringswet van 5 mei 2014. We proberen te duiden op welke manier in beide bronnen randvoorwaarden worden gecreëerd voor een hybride bestuursvorm in de sector. We staan kort stil bij beleidsmatige en juridische ontwikkelingen die vooraf gingen. [less ▲]

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See detailUne mata-analyse des degrés de certitude exprimés en mots
Leclercq, Dieudonné ULiege

in Evaluer : Journal International de Recherche en Education et Formation (2017), 2(3), 69-105

Asking to students to add a confidence degree to each of their responses to a test is rather rare, and the large majority of those who practice that use verbal scales such as “weakly sure”, “sure” ... [more ▼]

Asking to students to add a confidence degree to each of their responses to a test is rather rare, and the large majority of those who practice that use verbal scales such as “weakly sure”, “sure”, “strongly sure”, etc. instead of probabilities or percentages of chances. My hypothesis is that consists in introducing, from the beginning, an enormous random error of measurement since there exist large differences in the interpretation (the translation) into percentages of the word used in verbal scales. I demonstrated this in two experiences (Leclercq, 2016), one in context and one context free. A strong convergence appear in the results of the two experiences in terms of communicational fog produced by words in place of percentages (from 0% to 100%). Variation Ranges (VR) of translations of words into percentages have a modal value of 40% and standard deviations (SD) from 10% to 15%. Therefore my hypothesis is confirmed by these two experiences, but what does the specialized literature say? In a first part of the present article I have browsed many reviews and books with the purpose to find data that contribute to fight (and kill ?) this habit of using words instead of percentages to express confidence degrees. Therefore I have named my method a “mata” analysis (matar meaning “to kill” in Spanish), that is distinct from meta-analysis, as will be shown. In the second part of the article, I underline data that help approach what could be the optimal number of numerical degrees (and their exact values) not only in terms of students’ preferences, but mainly in terms of the reliability (measured but the repeatability criterion, i.e; stability in a short period of time) of the declared confidence. [less ▲]

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See detailOn the identification of paedomorphic and overwintering larval newts based on cloacal shape: review and guidelines
Denoël, Mathieu ULiege

in Current Zoology (2017), 63(2), 165-173

Paedomorphosis is an alternative process to metamorphosis in which adults retain larval traits at the adult stage. It is frequent in newts and salamanders, where larvae reach sexual maturity without ... [more ▼]

Paedomorphosis is an alternative process to metamorphosis in which adults retain larval traits at the adult stage. It is frequent in newts and salamanders, where larvae reach sexual maturity without losing their gills. However, in some populations, larvae overwinter in water, while remaining immature. These alternative ontogenetic processes are of particular interest in various research fields, but have different causes and consequences, as only paedomorphosis allows metamorphosis to be bypassed before maturity. It is thus relevant to efficiently identify paedomorphs versus overwintering larvae. In this context, the aim of this paper was threefold: firstly, to perform a meta-analysis of the identification procedures carried out in the literature; secondly, to determine the effectiveness of body size to make inferences about adulthood by surveying natural newt populations of Lissotriton helveticus and Ichthyosaura alpestris, and thirdly, to propose easy guidelines for an accurate distinction between large larvae and paedomorphs based on an external sexual trait, which is essential for reproduction — the cloaca. More than half of the studies in the literature do not mention the diagnostic criteria used for determining adulthood. The criteria mentioned were the presence of mature gonads (10%), eggs laid (4%), courtship behaviour (10%), and external morphological sexual traits (39%) including the cloaca (24%). Body-size thresholds should not be used as a proxy for paedomorphosis, because overwintering larvae can reach a larger size than paedomorphs within the same populations. In contrast, diagnosis based on cloacal external morphology is recommended, as it can be processed by the rapid visual assessment of all caught specimens, thus providing straightforward data at the individual level for both sexes. [less ▲]

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See detailAssessing the effect of pregnancy stage on milk composition of dairy cows using mid-infrared spectra
Laine, Aurélie ULiege; Bastin, Catherine; Grelet, Clément ULiege et al

in Journal of Dairy Science (2017), 100(4), 2863-2876

Changes in milk production traits (i.e., milk yield, fat, and protein contents) with the pregnancy stage are well documented. To our knowledge, the effect of pregnancy on the detailed milk composition has ... [more ▼]

Changes in milk production traits (i.e., milk yield, fat, and protein contents) with the pregnancy stage are well documented. To our knowledge, the effect of pregnancy on the detailed milk composition has not been studied so far. The mid-infrared (MIR) spectrum reflects the detailed composition of a milk sample and is obtained by a nonexhaustive and widely used method for milk analysis. Therefore, this study aimed to investigate the effect of pregnancy on milk MIR spectrum in addition to milk production traits (milk yield, fat, and protein contents). A model including regression on the number of days pregnant was applied on milk production traits (milk yield, fat, and protein contents) and on 212 spectral points from the MIR spectra of 9,757 primiparous Holstein cows from Walloon herds. Effects of pregnancy stage were expressed on a relative scale (effect divided by the squared root of the phenotypic variance); this allowed comparisons between effects on milk traits and on 212 spectral points. Effect of pregnancy stage on production traits were in line with previous studies indicating that the model accounted well for the pregnancy effect. Trends of the relative effect of the pregnancy stage on the 212 spectral points were consistent with known and observed effect on milk traits. The highest effect of the pregnancy was observed in the MIR spectral region from 968 to 1,577 cm−1. For some specific wavenumbers, the effect was higher than for fat and protein contents in the beginning of the pregnancy (from 30 to 90 or 120 d pregnant). In conclusion, the effect of early pregnancy can be observed in the detailed milk composition through the analysis of the MIR spectrum of bovine milk. Further analyses are warranted to explore deeply the use of MIR spectra of bovine milk for breeding and management of dairy cow pregnancy. [less ▲]

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See detailD’une victime à l’autre: Posture ou (im)posture victimaire?
Garcet, Serge ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2017), 2017/1

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See detailInterest of creatine supplementation insoccer
Miny, Kevin ULiege; Burrowes, J; Jidovtseff, Boris ULiege

in Science & Sports (2017), 32(2), 61-72

Objectives This review article aimed to summarize the current state of understanding on creatine supplementation for soccer players. In other words, it investigated the beneficial (and potentially ... [more ▼]

Objectives This review article aimed to summarize the current state of understanding on creatine supplementation for soccer players. In other words, it investigated the beneficial (and potentially negative) effects of this supplementation on sport-specific skills and performance in soccer players. Furthermore, this article accordingly discussed the safest and most recommended protocols for the consumption of creatine by these athletes. News Studies have shown that creatine supplementation can have positive effects on sprint and vertical jump performances in soccer players. This supplementation may also enhance soccer players’ muscle strength and adaptation to a high-intensity training regimen. Besides, creatine may be able to enhance muscle glycogen (as well as phosphocreatine) storage, reduce oxidative stress, and improve muscular repair and hypertrophy. Interestingly, creatine supplementation does not seem to affect aerobic performance. Prospects and projects Soccer players could take creatine during pre-season training (3 to 5g/day) in order to help them endure a high-intensity training regimen and enhance their muscular strength and adaptation resulting from strength and/or resistance training. A lower dosage (less than 3g/day) might also be sufficient and beneficial during the season in case of fatigue, in order to sustain adequate levels of phosphocreatine and glycogen in the muscles. Occasional intakes (about 3g) before games and/or extenuating practices could also give a physical and mental boost to the players. Conclusion Most of the studies measured the effects of creatine on skills or physical performances in isolation from the true athletic demands of soccer match play. In conclusion, there is still a need for more research in order to determine whether creatine supplementation is ergogenic regarding the (aerobic) capacity to repeat (very) high-intensity actions, more particularly during competitive soccer. [less ▲]

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See detail"La madone et la putain": Quand les stéréotypes de genres influencent la perception de la légalité des violences sexuelles et le traitement de la réaction sociale à l'égard des femmes
Garcet, Serge ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2017), 2017/1

Les illégalités liées au traitement différentiel des genres reposent notamment sur la présence de stéréotypes sexistes. L’article illustre comment les attitudes subjectivement positives à l’égard des ... [more ▼]

Les illégalités liées au traitement différentiel des genres reposent notamment sur la présence de stéréotypes sexistes. L’article illustre comment les attitudes subjectivement positives à l’égard des femmes que l’on peut qualifier de stéréotypes sexistes bienveillants influencent tant positivement que négativement la façon dont les femmes sont perçues par le système judiciaire. L’article souligne également au travers des représentations liées aux violences sexuelles l’impact des stéréotypes sexistes hostiles sur la perception de la légalité, de la légitimité perçue du passage à l’acte et du statut des victimes. [less ▲]

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See detailDecrease in climatic conditions favouring floods in the south-east of Belgium over 1959-2010 using the regional climate model MAR
Wyard, Coraline ULiege; Scholzen, Chloé ULiege; Fettweis, Xavier ULiege et al

in International Journal of Climatology (2017), 37(5), 27822796

The Ourthe River, in the south-east of Belgium, has a catchment area of 3,500 km2 and is one of the main tributaries of the Meuse River. In the Ourthe, most of the flood events occur during winter and ... [more ▼]

The Ourthe River, in the south-east of Belgium, has a catchment area of 3,500 km2 and is one of the main tributaries of the Meuse River. In the Ourthe, most of the flood events occur during winter and about 50% of them are due to heavy rainfall events combined to an abrupt melting of the snowpack covering the Ardennes massif during winter. This study aims to determine whether trends in extreme hydroclimatic events generating floods can be detected over the last century in Belgium, where a global warming signal can be observed. Hydroclimatic conditions favourable to floods were reconstructed over 1959- 2010 using the regional climate model MAR (“Modèle Atmosphérique Régional”) forced by the ERA-Interim/ERA-40, the ERA-20C and the NCEP/NCAR-v1 reanalyses. Extreme run-off events, which could potentially generate floods, were detected using run-off caused by precipitation events and snowpack melting from the MAR model. In the validation process, the MAR-driven temperature, precipitation and snow depth were successfully compared to daily weather data over the period 2008-2014 for 20 stations in Belgium. MAR also showed its ability to detect up to 90% of the hydroclimatic conditions which effectively generated observed floods in the Ourthe River over the period 1974- 2010. Conditions favourable to floods in the Ourthe River catchment present a negative trend over the period 1959-2010 as a result of a decrease in snow accumulation and a shortening of the snow season. This trend is expected to accelerate in a warmer climate. However, regarding the impact of the extreme precipitation events evolution on conditions favouring floods, the signal is less clear since the trends depend on the reanalysis used to force the MAR model. [less ▲]

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See detailIdentification of Shiga toxin-producing (STEC) and enteropathogenic (EPEC) Escherichia coli in diarrhoeic calves and comparative genomics of O5 bovine and human STEC
Fakih, Ibrahim; Thiry, Damien ULiege; Duprez, Jean-Noël ULiege et al

in Veterinary Microbiology (2017), 202

Escherichia coli producing Shiga toxins (Stx) and the attaching-effacing (AE) lesion (AE-STEC) are responsible for (bloody) diarrhoea in humans and calves while the enteropathogenic E. coli (EPEC ... [more ▼]

Escherichia coli producing Shiga toxins (Stx) and the attaching-effacing (AE) lesion (AE-STEC) are responsible for (bloody) diarrhoea in humans and calves while the enteropathogenic E. coli (EPEC) producing the AE lesion only cause non-bloody diarrhoea in all mammals. The purpose of this study was (i) to identify the pathotypes of enterohaemolysin-producing E. coli isolated between 2009 and 2013 on EHLY agar from less than 2 month-old diarrhoeic calves with a triplex PCR targeting the stx1, stx2, eae virulence genes; (ii) to serotype the positive isolates with PCR targeting the genes coding for ten most frequent and pathogenic human and calf STEC O serogroups; and (iii) to compare the MLSTypes and virulotypes of calf and human O5 AE-STEC after Whole Genome Sequencing using two server databases (www.genomicepidemiology.org). Of 233 isolates, 206 were triplex PCR-positive: 119 AE-STEC (58%), 78 EPEC (38%) and 9 STEC (4%); and the stx1+eae+ AE-STEC (49.5%) were the most frequent. Of them, 120 isolates (84% of AE-STEC, 23% of EPEC, 22% of STEC) tested positive with one O serogroup PCR: 57 for O26 (47.5%), 36 for O111 (30%), 10 for O103 (8%) and 8 for O5 (7%) serogroups. The analysis of the draft sequences of 15 O5 AE-STEC could not identify any difference correlated to the host. As a conclusion, (i) the AE-STEC associated with diarrhoea in young calves still belong to the same serogroups as previously (O5, O26, O111) but the O103 serogroup may be emerging, (ii) the O5 AE-STEC from calves and humans are genetically similar [less ▲]

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See detailDe geregistreerde criminaliteit van jongvolwassenen in Brussel : het belang van de soio-economische context
Vanneste, Charlotte ULiege; Ravier, Isabelle; Mahieu, Valentine

in Justice & Sécurité/ Justitie & Veiligheig, (2017)

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See detailL’ÉCHOGRAPHIE EN SITUATION DE SOIN : STÉTHOSCOPE DU FUTUR POUR LE MÉDECIN GÉNÉRALISTE ?
Henrard, Gilles ULiege; Froidcoeur, Xavier ULiege; Schoffeniels, Colombe et al

in Revue Médicale de Liège (2017)

Ultrasound is presently emerging not only as a specialist-delegated diagnostic procedure, but also as a tool used by clinicians for guiding decision. If this paradigm shift has taken roots in places like ... [more ▼]

Ultrasound is presently emerging not only as a specialist-delegated diagnostic procedure, but also as a tool used by clinicians for guiding decision. If this paradigm shift has taken roots in places like emergency departments, initiatives are also set up here and there in general practice. The aim of this article is , through a literature review, to identify possible indications of ultrasound performed by the general practitioner and to initiate a discussion about the obstacles and opportunities associated with its introduction in Belgian General Practice settings. [less ▲]

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See detailLes retardateurs de flamme bromés : impact sur l'environnement et la santé des individus exposés
Dufour, Patrice ULiege; Charlier, Corinne ULiege

in Annales de Biologie Clinique (2017), 75(2), 146-157

Depuis l’antiquité, l’homme utilise des moyens chimiques pour protéger ses biens des incendies. Efficaces et faciles d’emploi, les retardateurs de flamme bromés sont utilisés depuis plusieurs décennies de ... [more ▼]

Depuis l’antiquité, l’homme utilise des moyens chimiques pour protéger ses biens des incendies. Efficaces et faciles d’emploi, les retardateurs de flamme bromés sont utilisés depuis plusieurs décennies de façon massive dans l’industrie du plastique. À l’instar d’autres composés organohalogénés, les retardateurs de flamme bromés sont très persistants dans l’environnement et capables de s’accumuler le long de la chaîne alimentaire. De nombreux auteurs ont mis en évidence leur présence dans notre environnement, chez différentes espèces animales mais également dans le sérum humain. Plus inquiétant encore, l’homme est exposé à ces polluants dès la grossesse et par la suite via le lait maternel. Cette exposition pourrait avoir des conséquences sur notre santé. De nombreuses études in vitro, in vivo ou épidémiologiques ont mis en lumière une influence néfaste des retardateurs de flamme bromés sur notre système endocrinien, principalement au niveau de la fonction thyroïdienne mais également de la reproduction, du neurodéveloppement chez l’enfant et du métabolisme avec un risque accru de développer un diabète. Si une certaine prise de conscience a déjà eu lieu au niveau des autorités et de certaines grandes entreprises, de nouvelles études sont nécessaires pour confirmer les tendances déjà dégagées, élucider les mécanismes sous-jacents et déterminer s’il existe des synergies avec d’autres polluants tels que par exemple les PCB. [less ▲]

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See detailDeposition of ZnO based thin films by atmospheric pressure spatial atomic layer deposition for application in solar cells
Nguyen, Viet; Avelas Resende, João ULiege; Jimenez et al

in Journal of Renewable and Sustainable Energy (2017)

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See detailPlantations et bornage : prérogatives d'un emphytéote
Popa, Ruxandra ULiege

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2017), 3-4(2017),

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See detailROLE OF IMAGING IN LEFT ATRIAL APPENDAGE OCCLUSION
LEMPEREUR, Mathieu ULiege; AMINIAN, Adel; DULGHERU, Raluca Elena ULiege et al

in international journal of cardiovascular practice (2017), 2(2), 33-43

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See detailHigh concordance of Pfdhfr and Pfdhps genotypes between matched peripheral and placental isolates of delivered women in Bobo-Dioulasso, Burkina Faso
Cissé, Mamoudou; Awandare, Gordon; Some, Fabrice et al

in Annals of Parasitology (2017), 63(2), 111-116

Whether maternal peripheral parasites constitute a representative sample of the overall population infecting the individual, remains unknown in Burkina Faso. We therefore compared Pfdhfr and Pfdhps ... [more ▼]

Whether maternal peripheral parasites constitute a representative sample of the overall population infecting the individual, remains unknown in Burkina Faso. We therefore compared Pfdhfr and Pfdhps génotypes between matched peripheral and placental isolates. PCR-restriction fragment length polymorphism (PCR-RFLP) analysis of polymorphic codons of the Pfdhfr gene (51, 59, 108 and 164) and the Pfdhps gene (437 and 540) was performed in 18 matched peripheral and placental dried blood spots of delivered women in Bobo-Dioulasso. Both Pfdhfr and Pfdhps genes were successfully genotyped in 94.4% (17/18) of the matched samples. Only 8.8% (3/34) of génotypes were of the wild type, while 20.6% (7/34), 20.6% (7/34), 23.5% (8/34) and 26.5% (9/34) comprised one, two, three and four mutations, respectively. None of the samples carried both Pfdhfr I164L and Pfdhps K540E mutations. A concordance of 82.4% was observed in matched samples for both the Pfdhfr and Pfdhps genes. Setting placental allèles as the reference, a concordance of 100% was obtained with Pfdhfr mutation S108N, Pfdhfr mutation C59R+S108N, and Pfdhfr mutation N51I+C59R +S108N, respectively. Likewise, a concordance of 85.7% was observed with the Pfdhps mutation A437G. For epidemiological purposes, peripheral blood Pfdhfr and Pfdhps genotyping is sufficient for monitoring SP resistant molecular markers in pregnant women. [less ▲]

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See detailSize fractionation as a tool for separating charcoal of different fuel source and recalcitrance in the wildfire ash layer
Mastrolonardo, Giovanni ULiege

in Science of the Total Environment (2017), 595

Charcoal is a heterogeneous material exhibiting a diverse range of properties. This variability represents a serious challenge in studies that use the properties of natural charcoal for reconstructing ... [more ▼]

Charcoal is a heterogeneous material exhibiting a diverse range of properties. This variability represents a serious challenge in studies that use the properties of natural charcoal for reconstructing wildfires history in terrestrial ecosystems. In this study, we tested the hypothesis that particle size is a sufficiently robust indicator for separating forest wildfire combustion products into fractions with distinct properties. For this purpose, we examined two different forest environments affected by contrasting wildfires in terms of severity: an eucalypt forest in Australia, which experienced an extremely severe wildfire, and a Mediterranean pine forest in Italy, which burned to moderate severity. We fractionated the ash/charcoal layers collected on the ground into four size fractions (>2, 2–1, 1–0.5, <0.5 mm) and analysed them for mineral ash content, elemental composition, chemical structure (by IR spectroscopy), fuel source and charcoal reflectance (by reflected-light microscopy), and chemical/thermal recalcitrance (by chemical and thermal oxidation). At both sites, the finest fraction (<0.5 mm) had, by far, the greatest mass. The C concentration and C/N ratio decreased with decreasing size fraction, while pH and the mineral ash content followed the opposite trend. The coarser fractions showed higher contribution of amorphous carbon and stronger recalcitrance. We also observed that certain fuel types were preferentially represented by particular size fractions. We conclude that the differences between ash/charcoal size fractions were most likely primarily imposed by fuel source and secondarily by burning conditions. Size fractionation can therefore serve as a valuable tool to characterise the forest wildfire combustion products, as each fraction displays a narrower range of properties than the whole sample. We propose the mineral ash content of the fractions as criterion for selecting the appropriate number of fractions to analyse. [less ▲]

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See detailDFT investigation of the reaction mechanism for the guanidine catalyzed ring-opening of cyclic carbonates by aromatic and alkyl-amines
Alves, Margot ULiege; Méreau, Raphaël; Grignard, Bruno ULiege et al

in RSC Advances (2017), 7(31), 18993-19001

The guanidine catalysed aminolysis of propylene carbonate has been investigated using the density functional theory (DFT) and highlights that different reaction pathways are involved depending on the ... [more ▼]

The guanidine catalysed aminolysis of propylene carbonate has been investigated using the density functional theory (DFT) and highlights that different reaction pathways are involved depending on the aromatic or aliphatic nature of the amine. The structural ability of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) to simultaneously give and receive protons was demonstrated by a detailed mechanistic investigation. The bifunctional activity (base/H-bond donor) of TBD significantly reduces the Gibbs energy of the reaction and allows understanding its higher efficiency compared to its methyl counterpart (MTBD). [less ▲]

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See detailMacro-nutrient concentrations in Antarctic pack ice: Overall patterns and overlooked processes
Fripiat, François ULiege; Meiners, K.M.; Vancoppenolle, M. et al

in Elementa: Science of the Anthropocene (2017), 5(13),

Antarctic pack ice is inhabited by a diverse and active microbial community reliant on nutrients for growth. Seeking patterns and overlooked processes, we performed a large-scale compilation of macro ... [more ▼]

Antarctic pack ice is inhabited by a diverse and active microbial community reliant on nutrients for growth. Seeking patterns and overlooked processes, we performed a large-scale compilation of macro-nutrient data (hereafter termed nutrients) in Antarctic pack ice (306 ice-cores collected from 19 research cruises). Dissolved inorganic nitrogen and silicic acid concentrations change with time, as expected from a seasonally productive ecosystem. In winter, salinity-normalized nitrate and silicic acid concentrations (C*) in sea ice are close to seawater concentrations (Cw), indicating little or no biological activity. In spring, nitrate and silicic acid concentrations become partially depleted with respect to seawater (C* < Cw), commensurate with the seasonal build-up of ice microalgae promoted by increased insolation. Stronger and earlier nitrate than silicic acid consumption suggests that a significant fraction of the primary productivity in sea ice is sustained by flagellates. By both consuming and producing ammonium and nitrite, the microbial community maintains these nutrients at relatively low concentrations in spring. With the decrease in insolation beginning in late summer, dissolved inorganic nitrogen and silicic acid concentrations increase, indicating imbalance between their production (increasing or unchanged) and consumption (decreasing) in sea ice. Unlike the depleted concentrations of both nitrate and silicic acid from spring to summer, phosphate accumulates in sea ice (C* > Cw). The phosphate excess could be explained by a greater allocation to phosphorus-rich biomolecules during ice algal blooms coupled with convective loss of excess dissolved nitrogen, preferential remineralization of phosphorus, and/or phosphate adsorption onto metal-organic complexes. Ammonium also appears to be efficiently adsorbed onto organic matter, with likely consequences to nitrogen mobility and availability. This dataset supports the view that the sea ice microbial community is highly efficient at processing nutrients but with a dynamic quite different from that in oceanic surface waters calling for focused future investigations. [less ▲]

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See detailSimultaneous analysis of nucleobases, nucleosides and ginsenosides in ginseng extracts using supercritical fluid chromatography coupled with single quadrupole mass spectrometry
Huang, Yang ULiege; Zhang, Tingting; Zhao, Yumei et al

in Journal of Pharmaceutical and Biomedical Analysis (2017), 144(213), 219

Nucleobases, nucleosides and ginsenosides, which have a significant impact on the physiological activity of organisms, are reported to be the active components of ginseng, while they are less present in ... [more ▼]

Nucleobases, nucleosides and ginsenosides, which have a significant impact on the physiological activity of organisms, are reported to be the active components of ginseng, while they are less present in ginseng extracts. Few analytical methods have been developed so far to simultaneously analyze these three classes of compounds with different polarities present in ginseng extracts. In the present study, a simple and efficient analytical method was successfully developed for the simultaneous separation of 17 nucleobases, nucleosides and ginsenosides in ginseng extracts using supercritical fluid chromatography coupled with single quadrupole mass spectrometry (SFC-MS). The effect of various experimental factors on the separation performance, such as the column type, temperature and backpressure, the type of modifier and additive, and the concentration of make-up solvent were systematically investigated. Under the selected conditions, the developed method was successfully applied to the quality evaluation of 14 batches of ginseng extracts from different origins. The results obtained for the different batches indicate that this method could be employed for the quality assessment of ginseng extracts [less ▲]

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See detailBenchmarking carbon fluxes of the ISIMIP2a biome models
Chang, Jinfeng; Ciais, Philippe; Wang, Xuhui et al

in Environmental Research Letters (2017), 12

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See detailVARIATIONS OF TREE RING WIDTH AND CHEMICAL COMPOSITION OF WOOD OF PINE GROWING IN THE AREA NEARBY CHEMICAL FACTORIES
SENSUŁA, BARBARA; WILCZYŃSKI, SŁAWOMIR; MONIN, LAURENCE et al

in Geochronometria : Journal on Methods & Applications of Absolute Chronology (2017), 44

This study reports the variation of tree-ring widths and annual variation of concentration of metals (Na, Mg, Fe, Ni, Cu, Zn, Pb) in pine growing nearby chemical factories. The conifers (Pinus silvestris ... [more ▼]

This study reports the variation of tree-ring widths and annual variation of concentration of metals (Na, Mg, Fe, Ni, Cu, Zn, Pb) in pine growing nearby chemical factories. The conifers (Pinus silvestris L.) investigated in this study covered the time span from 1920s to 2010 AD. Tree-ring widths were measured, dated and rechecked using the COFECHA. Radial trace-element profiles were determined by Laser Ablation Inductively Coupled Plasma Mass Spectrometry. The combined usage of tree ring width and chemical composition of wood provides historic records of anthropogenic im- pact on the environment and allows identifying the behavior adaptation of trees to the pollution. Data of pine tree cores collected from the sites nearby chemical factories show increasing levels of pollu- tion linked to the increasing of industrial activities in Poland and subsequent dust fallout around the site. This study evidences that tree rings can be used as archives of past environmental contamination. [less ▲]

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See detailPromoting vaginal distribution of E7 and MCL-1 siRNA-silencing nanoparticles for cervical cancer treatment
Lechanteur, Anna ULiege; Furst, Tania; Delvenne, Philippe ULiege et al

in Molecular Pharmaceutics (2017)

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See detailOn-sky performance of the QACITS pointing control technique with the Keck/NIRC2 vortex coronagraph
Huby, Elsa ULiege; Bottom, Michael; Femenia, Bruno et al

in Astronomy and Astrophysics (2017), 600

A vortex coronagraph is now available for high contrast observations with the Keck/NIRC2 instrument at L band. Reaching the optimal performance of the coronagraph requires fine control of the wavefront ... [more ▼]

A vortex coronagraph is now available for high contrast observations with the Keck/NIRC2 instrument at L band. Reaching the optimal performance of the coronagraph requires fine control of the wavefront incident on the phase mask. In particular, centering errors can lead to significant stellar light leakage that degrades the contrast performance and prevents the observation of faint planetary companions around the observed stars. It is thus critical to correct for the possible slow drift of the star image from the phase mask center, generally due to mechanical flexures induced by temperature and/or gravity field variation, or to misalignment between the optics that rotate in pupil tracking mode. A control loop based on the QACITS algorithm for the vortex coronagraph has thus been developed and deployed for the Keck/NIRC2 instrument. This algorithm executes the entire observing sequence, including the calibration steps, initial centering of the star on the vortex center and stabilisation during the acquisition of science frames. On-sky data show that the QACITS control loop stabilizes the position of the star image down to 2.4 mas rms at a frequency of about 0.02 Hz. However, the accuracy of the estimator is probably limited by a systematic error due to a misalignment of the Lyot stop with respect to the entrance pupil, estimated to be on the order of 4.5 mas. A method to reduce the amplitude of this bias down to 1 mas is proposed. The QACITS control loop has been successfully implemented and provides a robust method to center and stabilize the star image on the vortex mask. In addition, QACITS ensures a repeatable pointing quality and significantly improves the observing efficiency compared to manual operations. It is now routinely used for vortex coronagraph observations at Keck/NIRC2, providing contrast and angular resolution capabilities suited for exoplanet and disk imaging. [less ▲]

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See detailBlood Biomarkers in Idiopathic Pulmonary Fibrosis.
GUIOT, Julien ULiege; Moermans, Catherine; Henket, Monique et al

in Lung (2017)

PURPOSE: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease of unknown origin whose incidence has been increasing over the latest decade partly as a consequence of population ... [more ▼]

PURPOSE: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease of unknown origin whose incidence has been increasing over the latest decade partly as a consequence of population ageing. New anti-fibrotic therapy including pirfenidone and nintedanib have now proven efficacy in slowing down the disease. Nevertheless, diagnosis and follow-up of IPF remain challenging. METHODS: This review examines the recent literature on potentially useful blood molecular and cellular biomarkers in IPF. Most of the proposed biomarkers belong to chemokines (IL-8, CCL18), proteases (MMP-1 and MMP-7), and growth factors (IGBPs) families. Circulating T cells and fibrocytes have also gained recent interest in that respect. Up to now, though several interesting candidates are profiling there has not been a single biomarker, which proved to be specific of the disease and predictive of the evolution (decline of pulmonary function test values, risk of acute exacerbation or mortality). CONCLUSION: Large scale multicentric studies are eagerly needed to confirm the utility of these biomarkers. [less ▲]

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See detailFrom Loose to Boxed Fragments and Back Again. Seriality and Archive in Chris Ware's ‘Building Stories’
Crucifix, Benoît ULiege

in Journal of Graphic Novels and Comics (2017)

This article focuses on the dynamics of seriality, archive and collection in Chris Ware's graphic novel “Building Stories”. It argues that the dispersed serialization of “Building Stories” is key to ... [more ▼]

This article focuses on the dynamics of seriality, archive and collection in Chris Ware's graphic novel “Building Stories”. It argues that the dispersed serialization of “Building Stories” is key to understand its box-of- comics format as well as its fragmented narrative structure. In a self-reflexive homage to the material history of comics, Ware's graphic novel indeed appears as an archive of its own serialization, foregrounding a process of collecting/dispersing fragments. [less ▲]

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See detailOLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages
QUESADA-CALVO, Florence ULiege; MASSOT, Charlotte ULiege; Bertrand, Virginie ULiege et al

in Clinical Proteomics (2017), 24(9),

Abstract Background: Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages ... [more ▼]

Abstract Background: Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages remains challenging and is important for reducing CRC incidence and increasing patient’s survival. Methods: We analysed 76 colorectal tissue samples originated from early CRC stages, normal or inflamed mucosa by label-free proteomics. The characterisation of three selected biomarker candidates was performed by immunohisto‑ chemistry on an independent set of precancerous and cancerous lesions harbouring increasing CRC stages. Results: Out of 5258 proteins identified, we obtained 561 proteins with a significant differential distribution among groups of patients and controls. KNG1, OLFM4 and Sec24C distributions were validated in tissues and showed differ‑ ent expression levels especially in the two early CRC stages compared to normal and preneoplastic tissues. Conclusion: We highlighted three proteins that require further investigations to better characterise their role in early CRC carcinogenesis and their potential as early CRC markers. [less ▲]

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See detailLight, dark and the powerd that be: a hydroelectric project in Butembo
Geenen, Kristien ULiege

in Canadian Journal of African Studies (2017), 51(1), 43-54

Despite its major importance in international trade, the city of Butembo in the North Kivu province of the Democratic Republic of Congo is deprived of such basic urban infrastructure as electricity ... [more ▼]

Despite its major importance in international trade, the city of Butembo in the North Kivu province of the Democratic Republic of Congo is deprived of such basic urban infrastructure as electricity. Private and public actors have attempted to bring power to the city, but their efforts have remained fruitless. Analysis of these failed projects to electrify the city offers a glimpse of local power relations. Why, rather than cooperating, do various local power holders counteract each other? Will gaining credit for bringing electric power to the city in turn yield political power over its future? With a special focus on a hydroelectric dam that was built but never functioned, this article sheds light on the way in which the citizens of Butembo relate to different bodies of authority. I argue that the hydroelectric dam gradually became a tool in a larger political strategy [less ▲]

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See detailIron minerals within specific microfossil morphospecies of the 1.88Ga Gunflint Formation
Lepot, kevin; Addad, Ahmed; Knoll, Andrew H et al

in Nature Communications (2017), DOI: 10.1038/ncomms14890

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See detailPotential uses of pumped urban groundwater. A case study in Sant Adrià del Besòs (Spain)
Jurado Elices, Anna ULiege; Vázquez-Suñé; Pujades, Estanislao ULiege

in Hydrogeology Journal (2017)

Urban groundwater has been over-exploited during the past, mainly for industrial uses, and it now tends to be reduced or abandoned due to pollution and/or changes in land use. The use and the subsequent ... [more ▼]

Urban groundwater has been over-exploited during the past, mainly for industrial uses, and it now tends to be reduced or abandoned due to pollution and/or changes in land use. The use and the subsequent disuse of groundwater resulted in rising water tables that damage underground structures (e.g., building basements and underground car parks and tunnels), leading to additional pumping in urban areas. This is the case of the underground parking lot of Sant Adrià del Besòs (NE Spain), where large amounts of urban groundwater are pumped to avoid seepage problems. The question that arises here is if this pumped groundwater can be used for other purposes (e.g., drinking water and urban irrigation) instead of wasting this valuable resource. To answer this question, it is necessary to quantify the groundwater recharge and to assess the evolution of ground-water quality in order to properly identify its potential uses. The limiting factor to define the uses of this resource is the groundwater quality because ammonium and some metals (iron and manganese) are present at high concentrations. Hence, further treatment would be needed to meet drinking water requirements. The pumped groundwater could also be used for supplying the ecological river flow and/or for mitigating seawater intrusion problems. Currently, only a small amount of this urban groundwater is used for cleaning public areas and watering public gardens. This situation highlighted the urgent need to manage this resource in a responsible and more efficient manner, especially in moments of high water demand such as drought periods. [less ▲]

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See detailOrganocatalytic coupling of CO2 with oxetane
Alves, Margot ULiege; Grignard, Bruno ULiege; Boyaval, Amélie ULiege et al

in ChemSusChem (2017), 10(6), 1128-1138

The organocatalytic coupling of CO2 with oxetanes is investigated under solvent-free conditions. The influence of the main reaction parameters (type of organocatalytic system, pressure and temperature) on ... [more ▼]

The organocatalytic coupling of CO2 with oxetanes is investigated under solvent-free conditions. The influence of the main reaction parameters (type of organocatalytic system, pressure and temperature) on the yield, the product formed and the selectivity of the reaction are discussed. An onium salt combined with a fluorinated alcohol promotes the efficient and selective organocatalytic synthesis of α,ω-hydroxyl oligocarbonates by coupling CO2 with oxetanes at 130 °C and at a CO2 pressure as low as 2 MPa. NMR characterizations were correlated with MALDI-ToF analyses for elucidating the structure of the oligomers. Online FTIR studies under pressure, NMR titrations and DFT calculations allowed an in-depth understanding of the reaction mechanism. Finally, CO2- based poly(carbonate-co-urethane)s were synthesized by step- growth polymerization of hydroxyl telechelic oligocarbonates with MDI. The organocatalytic system described in this paper constitutes an innovative sustainable route to the selective preparation of hydroxyl telechelic carbonates, of high interest for many applications, notably for the polyurethane business, especially for coatings or foams. [less ▲]

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See detailOrganocatalytic coupling of CO2 with a propargylic alcohol: a comprehensive study of the reaction mechanism combining in- situ ATR-IR spectroscopy and DFT calculations
Boyaval, Amélie ULiege; Méreau, Raphaël; Grignard, Bruno ULiege et al

in ChemSusChem (2017), 10(6), 1241-1248

The metal-free coupling of propargylic alcohols with carbon dioxide catalysed by guanidine derivatives was investigated in detail through the combination of online kinetic studies by in-situ ATR-IR ... [more ▼]

The metal-free coupling of propargylic alcohols with carbon dioxide catalysed by guanidine derivatives was investigated in detail through the combination of online kinetic studies by in-situ ATR-IR spectroscopy and DFT calculations. Bicyclic guanidines, namely TBD and MTBD, are effective catalysts for the conversion of 2-methyl-3-butyn-2-ol to α-methylene cyclic carbonate and oxoalkyl acyclic carbonate under mild reaction conditions. The lower selectivity of TBD in comparison with MTBD towards the formation of α-methylene cyclic carbonate was elucidated from DFT calculations and is related to the bifunctional activity (base/H-bond donor) of TBD decreasing the Gibbs free energy of the reaction path for the formation of the acyclic carbonate. Introduction [less ▲]

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See detailUltimate strength of cylindrical shells with cutouts
Eui Lee, Sang; Sahin; Rigo, Philippe ULiege et al

in Ships and Offshore Structures (2017)

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See detailKNN-MDR: a learning approach for improving interactions mapping performances in genome wide association studies
Abo Al Chamlat, Sinan ULiege; Farnir, Frédéric ULiege

in BMC Bioinformatics (2017), 18

Background Finding epistatic interactions in large association studies like genome-wide association studies (GWAS) with the nowadays-available large volume of genomic data is a challenging and largely ... [more ▼]

Background Finding epistatic interactions in large association studies like genome-wide association studies (GWAS) with the nowadays-available large volume of genomic data is a challenging and largely unsolved issue. Few previous studies could handle genome-wide data due to the intractable difficulties met in searching a combinatorial explosive search space and statistically evaluating epistatic interactions given a limited number of samples. Our work is a contribution to this field. We propose a novel approach combining K-Nearest Neighbors (KNN) and Multi Dimensional Reduction (MDR) methods for detecting gene-gene interactions as a possible alternative to existing algorithms, e especially in situations where the number of involved determinants is high. After describing the approach, a comparison of our method (KNN-MDR) to a set of the other most performing methods (i.e., MDR, BOOST, BHIT, MegaSNPHunter and AntEpiSeeker) is carried on to detect interactions using simulated data as well as real genome-wide data. Results Experimental results on both simulated data and real genome-wide data show that KNN-MDR has interesting properties in terms of accuracy and power, and that, in many cases, it significantly outperforms its recent competitors. Conclusions The presented methodology (KNN-MDR) is valuable in the context of loci and interactions mapping and can be seen as an interesting addition to the arsenal used in complex traits analyses. [less ▲]

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See detailSimultaneous synthesis and chemical functionalization of emulsion-templated porous polymers using nitroxide-terminated macromolecular surfactants
Mathieu, Kevin ULiege; De Winter, Julien; Jérôme, Christine ULiege et al

in Polymer Chemistry (2017), 8(11), 1850-1861

The design of functional 3D macroporous monoliths has become a necessity for a wide range of applications. Traditional post-modification strategies of porous materials are efficient but often consist in ... [more ▼]

The design of functional 3D macroporous monoliths has become a necessity for a wide range of applications. Traditional post-modification strategies of porous materials are efficient but often consist in tedious multi-steps processes. This work describes a straightforward macromolecular surfactant-assisted method for producing chemically functionalized macroporous polyHIPEs with interconnected structures. Accordingly, high internal phase emulsion-templated polymerizations were implemented in the presence of SG1-terminated amphiphilic copolymers prepared by nitroxide- mediated radical polymerization (NMP). The latter served as both stabilizers and functionalizing agents upon thermal activation of its terminal alkoxyamine and covalent anchoring of the released radical copolymer onto the walls of the scaffold. The effect of the polymerization temperature on the functionalization and openness of the final porous materials was explored. As a result, a range of open-cell styrene and acrylate-based polyHIPEs chemically grafted with PEO were obtained. Moreover, polyHIPEs were also decorated with alkyne-bearing PEO and subsequently modified via CuAAc click chemistry in order to demonstrate the potential of this macromolecular surfactants-assisted functionalization method. [less ▲]

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See detailYoung general practitioners’ professional activities: a survey in the French-speaking part of Belgium
Lenoir, Anne-Laure ULiege; Richelle, Lou; Ketterer, Frédéric ULiege et al

in Acta Clinica Belgica (2017)

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See detailInfluence of granular fraction and origin of recycled concrete aggregates on their properties
Zhao, Zengfeng ULiege; Courard, Luc ULiege; Michel, Frédéric ULiege et al

in European Journal of Environmental and Civil Engineering (2017)

Large quantities of construction and demolition wastes are produced each year. In order to make good use of recycled concrete aggregates (RCA) in concrete, it is very important to study the influence of ... [more ▼]

Large quantities of construction and demolition wastes are produced each year. In order to make good use of recycled concrete aggregates (RCA) in concrete, it is very important to study the influence of the granular fraction and the origin of RCA on their properties. In this study, RCA from industrial produced blocks (RCA_Blocks) and slabs (RCA_Slabs) were crushed and then separated into four granular fractions (0/2, 2/6.3, 6.3/14, 14/20 mm). Each granular fraction of RCA was physically characterised. Real RCA from recycling plant were also used for comparison. The results showed that recycled sands offered significantly higher cement paste content (higher bound water content) than coarse recycled aggregates. The fine RCA had therefore a higher water absorption coefficient compared to coarser fractions of RCA. The water absorption of finer fraction of RCA could be extrapolated precisely from the relationship between water absorption and cement paste content (or bound water content) of three coarse fractions of RCA. The values of hardened cement paste content obtained for the RCA_Blocks were lower than those measured on the RCA_Slabs, which was due to a smaller amount of initial cement paste content in blocks. The results showed that RCA_Slabs were more angular than RCA_Blocks. [less ▲]

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See detailWater Vapor Permeability of Edible Films Based on Improved Cassava (Manihot esculenta Crantz) Native Starches
Adjouman, Yao Désiré; Nindjin, Charlemagne; Tetchi, F.Achille et al

in Journal of Food Processing & Technology (2017), 8

Starch is used in the production of edible biodegradable packaging as an attractive alternative to synthetic polymers because it is a natural biopolymer of low cost and high availability. Many studies ... [more ▼]

Starch is used in the production of edible biodegradable packaging as an attractive alternative to synthetic polymers because it is a natural biopolymer of low cost and high availability. Many studies have been carried out on films based on cassava starch and the results show that these have good flexibility and low water vapor permeability. This present research was conducted to analyse the effect of glycerol, peanut oil and soybean lecithin on the water vapor permeability (WVP) of edible films based on improved cassava (Manihot esculenta Crantz) native starches from Côte d’Ivoire. The films were prepared using 4 g cassava starch, 25% and 30% glycerol (w/w), 5% and 10% peanut oil (w/w) and 0% to 5% soybean lecithin (w/w oil) in Petri dishes. The WVP of the films was determined at 25°C and 75% relative humidity. The moisture content of the films was determined in an oven at 105°C and the film thickness was determined manually using a micrometer. The resulting films were homogeneous, transparent and crack-free. WVP, moisture content and thickness of the films increased with increasing glycerol concentration. Increasing the concentrations of the peanut oil and soybean lecithin decreased the thickness and increased the moisture content of the films. The combination of glycerol and peanut oil increased the WVP of the films, whereas addition of soybean lecithin had no effect. The lowest WVP values were obtained using 25% glycerol, 5% peanut oil and 5% soybean lecithin. Starch obtained from improved cassava varieties cultivated in Côte d’Ivoire can be a potential ingredient in the production of food packaging. [less ▲]

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See detailRNAi inhibition of feruloyl CoA 6'-hydroxylase reduces scopoletin biosynthesis and post-harvest physiological deterioration in cassava (Manihot esculenta Crantz) storage roots.
Liu, Shi; Zainuddin, Ima M.; Vanderschuren, Hervé ULiege et al

in Plant Molecular Biology (2017)

Cassava (Manihot esculenta Crantz) is a major world crop, whose storage roots provide food for over 800 million throughout the humid tropics. Despite many advantages as a crop, the development of cassava ... [more ▼]

Cassava (Manihot esculenta Crantz) is a major world crop, whose storage roots provide food for over 800 million throughout the humid tropics. Despite many advantages as a crop, the development of cassava is seriously constrained by the rapid post-harvest physiological deterioration (PPD) of its roots that occurs within 24-72 h of harvest, rendering the roots unpalatable and unmarketable. PPD limits cassava's marketing possibilities in countries that are undergoing increased development and urbanisation due to growing distances between farms and consumers. The inevitable wounding of the roots caused by harvesting triggers an oxidative burst that spreads throughout the cassava root, together with the accumulation of secondary metabolites including phenolic compounds, of which the coumarin scopoletin (7-hydroxy-6-methoxy-2H-1-benzopyran-2-one) is the most abundant. Scopoletin oxidation yields a blue-black colour, which suggests its involvement in the discoloration observed during PPD. Feruloyl CoA 6'-hydroxylase is a controlling enzyme in the biosynthesis of scopoletin. The cassava genome contains a seven membered family of feruloyl CoA 6'-hydroxylase genes, four of which are expressed in the storage root and, of these, three were capable of functionally complementing Arabidopsis T-DNA insertion mutants in this gene. A RNA interference construct, designed to a highly conserved region of these genes, was used to transform cassava, where it significantly reduced feruloyl CoA 6'-hydroxylase gene expression, scopoletin accumulation and PPD symptom development. Collectively, our results provide evidence that scopoletin plays a major functional role in the development of PPD symptoms, rather than merely paralleling symptom development in the cassava storage root. [less ▲]

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See detailDevelopment of nuclear SNP markers for genetic tracking of Iroko, Milicia excelsa and Milicia regia
Blanc-Jolivet, Céline; Kersten, Birgit; Daïnou, Kasso ULiege et al

in Conservation Genetics Resources (2017)

Iroko, Milicia excelsa, is an economically important tropical hardwood species widely distributed in tropical Africa, from Ivory Coast in Western Africa to Tanzania in Eastern Africa. The species occurs ... [more ▼]

Iroko, Milicia excelsa, is an economically important tropical hardwood species widely distributed in tropical Africa, from Ivory Coast in Western Africa to Tanzania in Eastern Africa. The species occurs at low densities in contrasting habitats such as rainforest and woodlands. Former studies using chloroplast and nuclear sequences, as well as nSSRs, revealed a strong differentiation within the species among West and Central African populations and the presence of three genetic groups in Central Africa (Daïnou et al. 2010, 2014). The genus Milicia also includes another species, M. regia, co-occurring with M. excelsa in West Africa. Both species can be identified genetically and morphologically (Daïnou et al. 2014), but identification is difficult in the field. Although the spatial genetic structure of the species is well described, it is mostly based on nSSRs. Despite their lower diversity, SNP markers provide several advantages including the uncomplicated standardization of data among laboratories and the easy, rapid and low-cost development of markers for large sets of loci. These features make SNPs the ideal markers for setting up genetic reference data for timber tracking (Blanc-Jolivet and Liesebach 2015; Degen et al. 2017; Jardine et al. 2016; Pakull et al. 2016). In this paper, we describe the development of a new set of nuclear SNPs on M. excelsa meant to be used for genetic timber tracking. [less ▲]

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See detailStatistics of localized phase slips in tunable width planar point contacts
Baumans, Xavier ULiege; Zharinov, Vyacheslav; Raymenants, Eline et al

in Scientific Reports (2017), 7

The main dissipation mechanism in superconducting nanowires arises from phase slips. Thus far, most of the studies focus on long nanowires where coexisting events appear randomly along the nanowire. In ... [more ▼]

The main dissipation mechanism in superconducting nanowires arises from phase slips. Thus far, most of the studies focus on long nanowires where coexisting events appear randomly along the nanowire. In the present work we investigate highly confined phase slips at the contact point of two superconducting leads. Profiting from the high current crowding at this spot, we are able to shrink in-situ the nanoconstriction. This procedure allows us to investigate, in the very same sample, thermally activated phase slips and the probability density function of the switching current I sw needed to trigger an avalanche of events. Furthermore, for an applied current larger than I sw , we unveil the existence of two distinct thermal regimes. One corresponding to efficient heat removal where the constriction and bath temperatures remain close to each other, and another one in which the constriction temperature can be substantially larger than the bath temperature leading to the formation of a hot spot. Considering that the switching current distribution depends on the exact thermal properties of the sample, the identification of different thermal regimes is of utmost importance for properly interpreting the dissipation mechanisms in narrow point contacts. [less ▲]

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See detailModelling of organic Rankine cycle power systems in off-design conditions: an experimentally-validated comparative study
Dickes, Rémi ULiege; Dumont, Olivier ULiege; Daccord, Rémi et al

in Energy (2017), 123

Because of environmental issues and the depletion of fossil fuels, the world energy sector is undergoing many changes toward increased sustainability. Among the many fields of research and development ... [more ▼]

Because of environmental issues and the depletion of fossil fuels, the world energy sector is undergoing many changes toward increased sustainability. Among the many fields of research and development, power generation from low-grade heat sources is gaining interest and the organic Rankine cycle (ORC) is seen as one of the most promising technologies for such applications. In this paper, it is proposed to perform an experimentally-validated comparison of different modelling methods for the off-design simulation of ORC-based power systems. To this end, three types of modelling paradigms (namely a constant-efficiency method, a polynomial-based method and a semi-empirical method) are compared both in terms of their fitting and extrapolation capabilities. Post-processed measurements gathered on two experimental ORC facilities are used as reference for the models calibration and evaluation. The study is first applied at a component level (i.e. each component is analysed individually) and then extended to the characterization of the entire organic Rankine cycle power systems. Benefits and limi- tations of each modelling method are discussed. The results show that semi-empirical models are the most reliable for simulating the off-design working conditions of ORC systems, while constant-efficiency and polynomial-based models are both demonstrating lack of accuracy and/or robustness. [less ▲]

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See detailUnderground pumped storage hydropower plants using open pit mines: How do groundwater exchanges influence the efficiency?
Pujades, Estanislao ULiege; Orban, Philippe ULiege; Bodeux, Sarah ULiege et al

in Applied Energy (2017), 190

Underground Pumped Storage Hydropower (UPSH) is a potential alternative to manage electricity production in flat regions. UPSH plants will interact with the surrounding porous medium through exchanges of ... [more ▼]

Underground Pumped Storage Hydropower (UPSH) is a potential alternative to manage electricity production in flat regions. UPSH plants will interact with the surrounding porous medium through exchanges of groundwater. These exchanges may impact the surrounding aquifers, but they may also influence the efficiency of the pumps and turbines because affecting the head difference between the reservoirs. Despite the relevance for an accurate efficiency assessment, the influence of the groundwater exchanges has not been previously addressed. A numerical study of a synthetic case is presented to highlight the importance of considering the groundwater exchanges with the surrounding porous medium. The general methodology is designed in order to be further applied in the decision making of future UPSH plants introducing each case specific complexity. The underground reservoir of a hypothetical UPSH plant, which consists in an open pit mine, is considered and modelled together with the surrounding porous medium. Several scenarios with different characteristics are simulated and their results are compared in terms of (1) head difference between the upper and lower reservoirs and (2) efficiency by considering the theoretical performance curves of a pump and a turbine. The results show that the efficiency is improved when the groundwater exchanges increase. Thus, the highest efficiencies will be reached when (1) the underground reservoir is located in a transmissive porous medium and (2) the walls of the open pit mine do not constrain the groundwater exchanges (they are not waterproofed). However, a compromise must be found because the characteristics that increase the efficiency also increase the environmental impacts. Meaningful and reliable results are computed in relation to the characteristics of the intermittent and expected stops of UPSH plants. The frequency of pumping and injection must be considered to properly configure the pumps and turbines of future UPSH plants. If not, pumps and turbines could operate far from their best efficiency conditions. [less ▲]

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See detailDevelopment and validation of a fast SFC method for the analysis of flavonoids in plant extracts
Huang, Yang ULiege; Feng, Ying; Tang, Guangyun et al

in Journal of Pharmaceutical and Biomedical Analysis (2017), 140

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See detailMacroH2A histone variants maintain nuclear organization and heterochromatin architecture.
Douet, Julien; Corujo, David; Malinverni, Roberto et al

in Journal of Cell Science (2017)

Genetic loss-of-function studies in development, cancer and somatic cell reprogramming have suggested that the group of macroH2A histone variants might function through stabilizing the differentiated ... [more ▼]

Genetic loss-of-function studies in development, cancer and somatic cell reprogramming have suggested that the group of macroH2A histone variants might function through stabilizing the differentiated state by a yet unknown mechanism. Here, we present results demonstrating that macroH2A variants have a major function in maintaining nuclear organization and heterochromatin architecture. Specifically, we find that a substantial amount of macroH2A is associated with heterochromatic repeat sequences. We further identify macroH2A on sites of interstitial heterochromatin decorated by H3K9me3. Loss of macroH2A leads to major defects in nuclear organization including reduced nuclear circularity, disruption of nucleoli and a global loss of dense heterochromatin. Domains formed by repeat sequences when depleted of macroH2A are disorganized, expanded and fragmented and mildly re-expressed. On the molecular level we find that macroH2A is required for the interaction of repeat sequences with the nucleostructural protein Lamin B1. Taken together our results argue that a major function of macroH2A histone variants is to link nucleosome composition to higher order chromatin architecture. [less ▲]

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See detailStructure of Herbig AeBe disks at the milliarcsecond scale. A statistical survey in the H band using PIONIER-VLTI
Lazareff, B.; Berger, J.-P.; Kluska, J. et al

in Astronomy and Astrophysics (2017), 599

Context. It is now generally accepted that the near-infrared excess of Herbig AeBe stars originates in the dust of a circumstellar disk. Aims. The aims of this article are to infer the radial and vertical ... [more ▼]

Context. It is now generally accepted that the near-infrared excess of Herbig AeBe stars originates in the dust of a circumstellar disk. Aims. The aims of this article are to infer the radial and vertical structure of these disks at scales of order one au, and the properties of the dust grains. Methods. The program objects (51 in total) were observed with the H-band (1.6micron) PIONIER/VLTI interferometer. The largest baselines allowed us to resolve (at least partially) structures of a few tenths of an au at typical distances of a few hundred parsecs. Dedicated UBVRIJHK photometric measurements were also obtained. Spectral and 2D geometrical parameters are extracted via fits of a few simple models: ellipsoids and broadened rings with azimuthal modulation. Model bias is mitigated by parallel fits of physical disk models. Sample statistics were evaluated against similar statistics for the physical disk models to infer properties of the sample objects as a group. Results. We find that dust at the inner rim of the disk has a sublimation temperature Tsub~1800K. A ring morphology is confirmed for approximately half the resolved objects; these rings are wide delta_r>=0.5. A wide ring favors a rim that, on the star-facing side, looks more like a knife edge than a doughnut. The data are also compatible with a the combination of a narrow ring and an inner disk of unspecified nature inside the dust sublimation radius. The disk inner part has a thickness z/r~0.2, flaring to z/r~0.5 in the outer part. We confirm the known luminosity-radius relation; a simple physical model is consistent with both the mean luminosity-radius relation and the ring relative width; however, a significant spread around the mean relation is present. In some of the objects we find a halo component, fully resolved at the shortest interferometer spacing, that is related to the HAeBe class. [less ▲]

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See detailStrategic Points in Aquaponics
Junge, Ranka; König, Bettina; Villarroel, Morris et al

in Water (2017), 9(182),

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See detailBehavior of digital sequences through exotic numeration systems
Leroy, Julien ULiege; Rigo, Michel ULiege; Stipulanti, Manon ULiege

in Electronic Journal of Combinatorics (2017), 24(1), 14436

Many digital functions studied in the literature, e.g., the summatory function of the base-k sum-of-digits function, have a behavior showing some periodic fluctuation. Such functions are usually studied ... [more ▼]

Many digital functions studied in the literature, e.g., the summatory function of the base-k sum-of-digits function, have a behavior showing some periodic fluctuation. Such functions are usually studied using techniques from analytic number theory or linear algebra. In this paper we develop a method based on exotic numeration systems and we apply it on two examples motivated by the study of generalized Pascal triangles and binomial coefficients of words. [less ▲]

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See detailBioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule
Thiry, Justine ULiege; Kok, Miranda ULiege; Collard, Laurence ULiege et al

in European Journal of Pharmaceutical Sciences (2017), 99

Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt ... [more ▼]

Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility of less than 1 ng/mL, the aim of this work was to enhance the aqueous solubility of ITZ, and thereby improve its bioavailability. The three formulations consisted of a simple SOL/ITZ amorphous solid dispersion (ASD), an optimized SOL/ITZ/AcDiSol® (super-disintegrant) ASD and an equimolar inclusion complex of ITZ in hydroxypropyl-β-cyclodextrin (substitution degree = 0.63, CD) with SOL. The three formulations were compared in vitro and in vivo to the marketed product Sporanox®. The in vitro enhancement of dissolution rate was evaluated using a biphasic dissolution test. In vitro dissolution results showed that all three formulations had a higher percentage of ITZ released than Sporanox® with the following ranking: SOL/ITZ/CD > SOL/ITZ/AcDiSol® > SOL/ITZ > Sporanox®. The bioavailability of these four formulations was evaluated in rats. The bioanalytical method was optimized so that only 10 μL of blood was withdrawn from the rats using specific volumetric absorptive microsampling devices. This enabled to keep the same rats during the whole study, which was in accordance with the Three Rs rules (reduction, refinement and replacement). Furthermore, this technique allowed the suppression of inter-individual variability. Higher Cmax and AUC were obtained after the administration of all three formulations compared to the levels after the use of Sporanox® as follows: SOL/ITZ/AcDiSol® > SOL/ITZ/CD > SOL/ITZ > Sporanox®. The inversion in the ranking between SOL/ITZ/CD and SOL/ITZ/AcDiSol® made impossible the establishment of an in vitro–vivo correlation. Indeed, very different release rates were obtained in vitro and in vivo for the two optimized formulations. These results suggest that ITZ would be protected inside the core of the SOL micelles even during the absorption step at the intestine, while some agents present in the intestinal fluids could displace ITZ from the hydrophobic cavity of CD by competition. [less ▲]

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See detailPerspectives for observing hot massive stars with XMM-Newton in the years 2017-2027
Rauw, Grégor ULiege

in Astronomische Nachrichten (2017), 338

XMM-Newton has deeply changed our picture of X-ray emission of hot, massive stars. High-resolution X-ray spectroscopy as well as monitoring of these objects helped us gain a deeper insight into the ... [more ▼]

XMM-Newton has deeply changed our picture of X-ray emission of hot, massive stars. High-resolution X-ray spectroscopy as well as monitoring of these objects helped us gain a deeper insight into the physics of single massive stars with or without magnetic fields, as well as of massive binary systems, where the stellar winds of both stars interact. These observations also revealed a number of previously unexpected features that challenge our understanding of the dynamics of the stellar winds of massive stars. I briefly summarize the results obtained over the past 15 years and highlight the perspectives for the next decade. It is anticipated that coordinated (X-ray and optical or UV) monitoring and time-critical observations of either single or binary massive stars will become the most important topics in this field over the coming years. Synergies with existing or forthcoming X-ray observatories (NuSTAR, Swift, eROSITA) will also play a major role and will further enhance the importance of XMM-Newton in our quest for understanding the physics of hot, massive stars. [less ▲]

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See detailAdaptive PSF fitting - a highly performing photometric method and light curves of the GLS H1413+117: time delays and micro-lensing effects
Akhunov, Talat ULiege; Wertz, O.; Elyiv, A. et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

We present new photometric observations of H1413+117 acquired during seasons between 2001 and 2008 in order to estimate the time delays between the lensed quasar images and to characterize at best the on ... [more ▼]

We present new photometric observations of H1413+117 acquired during seasons between 2001 and 2008 in order to estimate the time delays between the lensed quasar images and to characterize at best the on-going micro-lensing events. We propose a highly performing photometric method called the adaptive point spread function fitting and have successfully tested this method on a large number of simulated frames. This has enabled us to estimate the photometric error bars affecting our observational results. We analysed the V- and R-band light curves and V-R colour variations of the A-D components which show short- and long-term brightness variations correlated with colour variations. Using the χ[SUP]2[/SUP] and dispersion methods, we estimated the time delays on the basis of the R-band light curves over the seasons between 2003 and 2006. We have derived the new values: Δt[SUB]AB[/SUB] = -17.4 ± 2.1, Δt[SUB]AC[/SUB] = -18.9 ± 2.8 and Δt[SUB]AD[/SUB] = 28.8 ± 0.7 d using the χ[SUP]2[/SUP] method (B and C are leading, D is trailing) with 1σ confidence intervals. We also used available observational constraints (resp. the lensed image positions, the flux ratios in mid-IR and two sets of time delays derived in the present work) to update the lens redshift estimation. We obtained z_l = 1.95^{+0.06}_{-0.10} which is in good agreement with previous estimations. We propose to characterize two kinds of micro-lensing events: micro-lensing for the A, B, C components corresponds to typical variations of ∼10[SUP]-4[/SUP] mag d[SUP]-1[/SUP] during all the seasons, while the D component shows an unusually strong micro-lensing effect with variations of up to ∼10[SUP]-3[/SUP] mag d[SUP]-1[/SUP] during 2004 and 2005. [less ▲]

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See detailLacustrine clay mineral assemblages as a proxy for land-use and climate changes over the last 4 kyr: The Amik Lake case study, Southern Turkey
El Ouahabi, Meriam ULiege; Hubert, Aurelia ULiege; Fagel, Nathalie ULiege

in Quaternary International (2017), 1/15

Lake sediments are sensitive to landscape changes and most of these changes seem to be modulated by land-use (anthropogenic factors) coupled to palaeoenvironmental/palaeoclimatic changes. In its detrital ... [more ▼]

Lake sediments are sensitive to landscape changes and most of these changes seem to be modulated by land-use (anthropogenic factors) coupled to palaeoenvironmental/palaeoclimatic changes. In its detrital fraction, the lacustrine sediments record the history of soil erosion within its catchment via the inputs of clays and others detrital products. Within a Mediterranean context, the study investigates the upper sediments infilling the central part of the Amik basin in southern Turkey. This tectonic basin was occupied and exploited by modern human at least since 6000-7000 BC. We focus on the clay mineralogy (x-ray diffraction on oriented aggregates) and magnetic susceptibility measurements (Bartington) of the sedimentary record in the area over the last 4000 years, to assess environmental changes in relation with the different land uses and/or weathering during the successive Bronze, Iron, Roman, Islamic/Ottoman and Modern civilizations. The clay fraction of Amik Lake sediments comprises smectite, kaolinite, illite, chlorite and chlorite/smectite mixed layers that are the inherited clay phases. A relative change in abundance and crystallinity and chemistry of illite attests that environmental conditions evolved in the Amik Plain from the Bronze to Modern Age in relation with climates and/or land-use changes. The history of the Amik Lake reveals different soil erosion episode. The most intense erosion phase occurred during the Bronze/Iron Ages as indicated by the clay and magnetic susceptibility proxies. The Roman period was an exceptional period with soil erosion products arriving from the watershed, probably due the water channelization. A reduction of soil erosion occurred during the post Roman period until nowadays. Significant pedogenesis transformations are evidenced, especially during the Islamic/Ottoman periods suggesting intense chemical weathering conditions related to climate change. [less ▲]

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See detailThe XXL survey: First results and future
Pierre, M.; Adami, C.; Birkinshaw, M. et al

in Astronomische Nachrichten (2017), 338

The XXL survey currently covers two 25 sq. deg. patches with XMM observations of ~10ks. We summarise the scientific results associated with the first release of the XXL data set, that occurred mid 2016 ... [more ▼]

The XXL survey currently covers two 25 sq. deg. patches with XMM observations of ~10ks. We summarise the scientific results associated with the first release of the XXL data set, that occurred mid 2016. We review several arguments for increasing the survey depth to 40 ks during the next decade of XMM operations. X-ray (z<2) cluster, (z<4) AGN and cosmic background survey science will then benefit from an extraordinary data reservoir. This, combined with deep multi-$\lambda$ observations, will lead to solid standalone cosmological constraints and provide a wealth of information on the formation and evolution of AGN, clusters and the X-ray background. In particular, it will offer a unique opportunity to pinpoint the z>1 cluster density. It will eventually constitute a reference study and an ideal calibration field for the upcoming eROSITA and Euclid missions. [less ▲]

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See detailH0LiCOW - IV. Lens mass model of HE 0435-1223 and blind measurement of its time-delay distance for cosmology
Wong, Kenneth C.; Suyu, Sherry H.; Auger, Matthew W. et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

Strong gravitational lenses with measured time delays between the multiple images allow a direct measurement of the time-delay distance to the lens, and thus a measure of cosmological parameters ... [more ▼]

Strong gravitational lenses with measured time delays between the multiple images allow a direct measurement of the time-delay distance to the lens, and thus a measure of cosmological parameters, particularly the Hubble constant, H[SUB]0[/SUB]. We present a blind lens model analysis of the quadruply imaged quasar lens HE 0435-1223 using deep Hubble Space Telescope imaging, updated time-delay measurements from the COSmological MOnitoring of GRAvItational Lenses (COSMOGRAIL), a measurement of the velocity dispersion of the lens galaxy based on Keck data, and a characterization of the mass distribution along the line of sight. HE 0435-1223 is the third lens analysed as a part of the H[SUB]0[/SUB] Lenses in COSMOGRAIL's Wellspring (H0LiCOW) project. We account for various sources of systematic uncertainty, including the detailed treatment of nearby perturbers, the parametrization of the galaxy light and mass profile, and the regions used for lens modelling. We constrain the effective time-delay distance to be D_{Δ t}= 2612_{-191}^{+208} Mpc, a precision of 7.6 per cent. From HE 0435-1223 alone, we infer a Hubble constant of H[SUB]0[/SUB] = 73.1_{-6.0}^{+5.7} km s^{-1 Mpc^{-1}} assuming a flat ΛCDM cosmology. The cosmographic inference based on the three lenses analysed by H0LiCOW to date is presented in a companion paper (H0LiCOW Paper V). [less ▲]

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See detailEvolutionary status of the Of?p star HD 148937 and of its surrounding nebula NGC 6164/5
Mahy, Laurent ULiege; Hutsemekers, Damien ULiege; Nazé, Yaël ULiege et al

in Astronomy and Astrophysics (2017), 599(A61), 17

<BR /> Aims: The magnetic star HD 148937 is the only Galactic Of?p star surrounded by a nebula. The structure of this nebula is particularly complex and is composed, from the center out outwards, of a ... [more ▼]

<BR /> Aims: The magnetic star HD 148937 is the only Galactic Of?p star surrounded by a nebula. The structure of this nebula is particularly complex and is composed, from the center out outwards, of a close bipolar ejecta nebula (NGC 6164/5), an ellipsoidal wind-blown shell, and a spherically symmetric Strömgren sphere. The exact formation process of this nebula and its precise relation to the star's evolution remain unknown. <BR /> Methods: We analyzed infrared Spitzer IRS and far-infrared Herschel/PACS observations of the NGC 6164/5 nebula. The Herschel imaging allowed us to constrain the global morphology of the nebula. We also combined the infrared spectra with optical spectra of the central star to constrain its evolutionary status. We used these data to derive the abundances in the ejected material. To relate this information to the evolutionary status of the star, we also determined the fundamental parameters of HD 148937 using the CMFGEN atmosphere code. <BR /> Results: The Hα image displays a bipolar or "8"-shaped ionized nebula, whilst the infrared images show dust to be more concentrated around the central object. We determine nebular abundance ratios of N/O = 1.06 close to the star, and N/O = 1.54 in the bright lobe constituting NGC 6164. Interestingly, the parts of the nebula located further from HD 148937 appear more enriched in stellar material than the part located closer to the star. Evolutionary tracks suggest that these ejecta have occured 1.2-1.3 and 0.6 Myr ago, respectively. In addition, we derive abundances of argon for the nebula compatible with the solar values and we find a depletion of neon and sulfur. The combined analyses of the known kinematics and of the new abundances of the nebula suggest either a helical morphology for the nebula, possibly linked to the magnetic geometry, or the occurrence of a binary merger. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Based in part on observations collected at the European Southern Observatory, in Chile. [less ▲]

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See detailBioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells
Gulfam, Muhammad ULiege; Matini, Teresa; Monteiro, Patrícia F et al

in Biomaterials Science (2017), 5(3), 532-550

Polymer micelles have emerged as promising carriers for controlled release applications, however, several limitations of micelle-based drug delivery have also been reported. To address these issues, we ... [more ▼]

Polymer micelles have emerged as promising carriers for controlled release applications, however, several limitations of micelle-based drug delivery have also been reported. To address these issues, we have synthesized a functional biodegradable and cytocompatible block copolymer based on methoxypoly (ethyleneglycol)-b-poly(ε-caprolactone-co-α-azido-ε-caprolactone) (mPEG-b-poly(εCL-co-αN3εCL)) as a precursor of reduction sensitive core-crosslinked micelles. The synthesized polymer was formulated as micelles using a dialysis method and loaded with the anti-inflammatory and anti-cancer drug metho- trexate (MTX). The micellar cores were subsequently crosslinked at their pendent azides by a redox- responsive bis(alkyne). The size distributions and morphology of the polymer micelles were assessed using dynamic light scattering (DLS) and transmission electron microscopy, and drug release assays were performed under simplified (serum free) physiological and reductive conditions. Cellular uptake studies in human breast cancer cells were performed using Oregon-green loaded core-crosslinked micelles. The MTX-loaded core-crosslinked micelles were assessed for their effects on metabolic activity in human breast cancer (MCF-7) cells by evaluating the reduction of the dye MTT 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide. The apoptosis inducing potential of MTX-loaded core-crosslinked micelles was analysed using Hoechst/propidium iodide (PI) and annexin-V/PI assays. The data from these experi- ments indicated that drug release from these cross-linked micelles can be controlled and that the redox- responsive micelles are more effective carriers for MTX than non-crosslinked analogues and the free drug in the cell-lines tested. [less ▲]

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See detailReconnaissance of the TRAPPIST-1 exoplanet system in the Lyman-α line
Bourrier, V.; Ehrenreich, D.; Wheatley, P. J. et al

in Astronomy and Astrophysics (2017), 599

The TRAPPIST-1 system offers the opportunity to characterize terrestrial, potentially habitable planets orbiting a nearby ultracool dwarf star. We performed a four-orbit reconnaissance with the Space ... [more ▼]

The TRAPPIST-1 system offers the opportunity to characterize terrestrial, potentially habitable planets orbiting a nearby ultracool dwarf star. We performed a four-orbit reconnaissance with the Space Telescope Imaging Spectrograph onboard the Hubble Space Telescope to study the stellar emission at Lyman-α, to assess the presence of hydrogen exospheres around the two inner planets, and to determine their UV irradiation. We detect the Lyman-α line of TRAPPIST-1, making it the coldest exoplanet host star for which this line has been measured. We reconstruct the intrinsic line profile, showing that it lacks broad wings and is much fainter than expected from the stellar X-ray emission. TRAPPIST-1 has a similar X-ray emission as Proxima Cen but a much lower Ly-α emission. This suggests that TRAPPIST-1 chromosphere is only moderately active compared to its transition region and corona. We estimated the atmospheric mass loss rates for all planets, and found that despite a moderate extreme UV emission the total XUV irradiation could be strong enough to strip the atmospheres of the inner planets in a few billions years. We detect marginal flux decreases at the times of TRAPPIST-1b and c transits, which might originate from stellar activity, but could also hint at the presence of extended hydrogen exospheres. Understanding the origin of these Lyman-α variations will be crucial in assessing the atmospheric stability and potential habitability of the TRAPPIST-1 planets. [less ▲]

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See detailH0LiCOW - V. New COSMOGRAIL time delays of HE 0435-1223: H0 to 3.8 per cent precision from strong lensing in a flat ΛCDM model
Bonvin, V.; Courbin, F.; Suyu, S. H. et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

We present a new measurement of the Hubble Constant H[SUB]0[/SUB] and other cosmological parameters based on the joint analysis of three multiply imaged quasar systems with measured gravitational time ... [more ▼]

We present a new measurement of the Hubble Constant H[SUB]0[/SUB] and other cosmological parameters based on the joint analysis of three multiply imaged quasar systems with measured gravitational time delays. First, we measure the time delay of HE 0435-1223 from 13-yr light curves obtained as part of the COSMOGRAIL project. Companion papers detail the modelling of the main deflectors and line-of-sight effects, and how these data are combined to determine the time-delay distance of HE 0435-1223. Crucially, the measurements are carried out blindly with respect to cosmological parameters in order to avoid confirmation bias. We then combine the time-delay distance of HE 0435-1223 with previous measurements from systems B1608+656 and RXJ1131-1231 to create a Time Delay Strong Lensing probe (TDSL). In flat Λ cold dark matter (ΛCDM) with free matter and energy density, we find H[SUB]0[/SUB] =71.9^{+2.4}_{-3.0} {km s^{-1} Mpc^{-1}} and Ω _{Λ }=0.62^{+0.24}_{-0.35}. This measurement is completely independent of, and in agreement with, the local distance ladder measurements of H[SUB]0[/SUB]. We explore more general cosmological models combining TDSL with other probes, illustrating its power to break degeneracies inherent to other methods. The joint constraints from TDSL and Planck are H[SUB]0[/SUB] = 69.2_{-2.2}^{+1.4} {km s^{-1} Mpc^{-1}}, Ω _{Λ }=0.70_{-0.01}^{+0.01} and Ω _k=0.003_{-0.006}^{+0.004} in open ΛCDM and H[SUB]0[/SUB] =79.0_{-4.2}^{+4.4} {km s^{-1} Mpc^{-1}}, Ω _de=0.77_{-0.03}^{+0.02} and w=-1.38_{-0.16}^{+0.14} in flat wCDM. In combination with Planck and baryon acoustic oscillation data, when relaxing the constraints on the numbers of relativistic species we find N[SUB]eff[/SUB] = 3.34_{-0.21}^{+0.21} in N[SUB]eff[/SUB]ΛCDM and when relaxing the total mass of neutrinos we find Σm[SUB]ν[/SUB] ≤ 0.182 eV in m[SUB]ν[/SUB]ΛCDM. Finally, in an open wCDM in combination with Planck and cosmic microwave background lensing, we find H[SUB]0[/SUB] =77.9_{-4.2}^{+5.0} {km s^{-1} Mpc^{-1}}, Ω _de=0.77_{-0.03}^{+0.03}, Ω _k=-0.003_{-0.004}^{+0.004} and w=-1.37_{-0.23}^{+0.18}. [less ▲]

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See detailMagnetic reconnection during steady magnetospheric convection and other magnetospheric modes
Hubert, Benoît ULiege; Gérard, Jean-Claude ULiege; Milan, Steve E. et al

in Annales Geophysicae (2017), 35

We use remote sensing of the proton aurora with the IMAGE-FUV SI12 (Imager for Magnetopause to Aurora Global Exploration-Far Ultraviolet-Spectrographic Imaging at 121.8 nm) instrument and radar ... [more ▼]

We use remote sensing of the proton aurora with the IMAGE-FUV SI12 (Imager for Magnetopause to Aurora Global Exploration-Far Ultraviolet-Spectrographic Imaging at 121.8 nm) instrument and radar measurements of the ionospheric convection from the SuperDARN (Super Dual Aurora Radar Network) facility to estimate the open magnetic flux in the Earth's magnetosphere and the reconnection rates at the dayside magnetopause and in the magnetotail during intervals of steady magnetospheric convection (SMC). We find that SMC intervals occur with relatively high open magnetic flux (average ˜ 0.745 GWb, standard deviation ˜ 0.16 GWb), which is often found to be nearly steady, when the magnetic flux opening and closure rates approximately balance around 55 kV on average, with a standard deviation of 21 kV. We find that the residence timescale of open magnetic flux, defined as the ratio between the open magnetospheric flux and the flux closure rate, is roughly 4 h during SMCs. Interestingly, this number is approximately what can be deduced from the discussion of the length of the tail published by Dungey (1965), assuming a solar wind speed of ˜ 450 km s[SUP]-1[/SUP]. We also infer an enhanced convection velocity in the tail, driving open magnetic flux to the nightside reconnection site. We compare our results with previously published studies in order to identify different magnetospheric modes. These are ordered by increasing open magnetic flux and reconnection rate as quiet conditions, SMCs, substorms (with an important overlap between these last two) and sawtooth intervals. [less ▲]

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See detailWASP-South transiting exoplanets: WASP-130b, WASP-131b, WASP-132b, WASP-139b, WASP-140b, WASP-141b & WASP-142b
Hellier, Coel; Anderson, D. R.; Collier Cameron, A. et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

We describe seven new exoplanets transiting stars of V = 10.1 to 12.4. WASP-130b is a "warm Jupiter" having an orbital period of 11.6 d, the longest yet found by WASP. It transits a V = 11.1, G6 star with ... [more ▼]

We describe seven new exoplanets transiting stars of V = 10.1 to 12.4. WASP-130b is a "warm Jupiter" having an orbital period of 11.6 d, the longest yet found by WASP. It transits a V = 11.1, G6 star with [Fe/H] = +0.26. Warm Jupiters tend to have smaller radii than hot Jupiters, and WASP-130b is in line with this trend (1.23 Mjup; 0.89 Rjup). WASP-131b is a bloated Saturn-mass planet (0.27 Mjup; 1.22 Rjup). Its large scale height coupled with the V = 10.1 brightness of its host star make the planet a good target for atmospheric characterisation. WASP-132b is among the least irradiated and coolest of WASP planets, being in a 7.1-d orbit around a K4 star. It has a low mass and a modest radius (0.41 Mjup; 0.87 Rjup). The V = 12.4, [Fe/H] = +0.22 star shows a possible rotational modulation at 33 d. WASP-139b is the lowest-mass planet yet found by WASP, at 0.12 Mjup and 0.80 Rjup. It is a "super-Neptune" akin to HATS-7b and HATS-8b. It orbits a V = 12.4, [Fe/H] = +0.20, K0 star. The star appears to be anomalously dense, akin to HAT-P-11. WASP-140b is a 2.4-Mjup planet in a 2.2-d orbit that is both eccentric (e = 0.047) and with a grazing transit (b = 0.93) The timescale for tidal circularisation is likely to be the lowest of all known eccentric hot Jupiters. The planet's radius is large (1.4 Rjup), but uncertain owing to the grazing transit. The host star is a V = 11.1, [Fe/H] = +0.12, K0 dwarf showing a prominent 10.4-d rotational modulation. The dynamics of this system are worthy of further investigation. WASP-141b is a typical hot Jupiter, being a 2.7 Mjup, 1.2 Rjup planet in a 3.3-d orbit around a V = 12.4, [Fe/H] = +0.29, F9 star. WASP-142b is a typical bloated hot Jupiter (0.84 Mjup, 1.53 Rjup) in a 2.1-d orbit around a V = 12.3, [Fe/H] = +0.26, F8 star. [less ▲]

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See detailTwo massive rocky planets transiting a K-dwarf 6.5 parsecs away
Gillon, Michaël ULiege; Demory, Brice-Olivier; Van Grootel, Valérie ULiege et al

in Nature Astronomy (2017), 1

HD 219134 is a K-dwarf star at a distance of 6.5 parsecs around which several low-mass planets were recently discovered[SUP]1,2[/SUP]. The Spitzer Space Telescope detected a transit of the innermost of ... [more ▼]

HD 219134 is a K-dwarf star at a distance of 6.5 parsecs around which several low-mass planets were recently discovered[SUP]1,2[/SUP]. The Spitzer Space Telescope detected a transit of the innermost of these planets, HD 219134 b, whose mass and radius (4.5 M[SUB]⊕[/SUB] and 1.6 R[SUB]⊕[/SUB] respectively) are consistent with a rocky composition[SUP]1[/SUP]. Here, we report new high-precision time-series photometry of the star acquired with Spitzer revealing that the second innermost planet of the system, HD 219134c, is also transiting. A global analysis of the Spitzer transit light curves and the most up-to-date HARPS-N velocity data set yields mass and radius estimations of 4.74 ± 0.19 M[SUB]⊕[/SUB] and 1.602 ± 0.055 R[SUB]⊕[/SUB] for HD 219134 b, and of 4.36 ± 0.22 M[SUB]⊕[/SUB] and 1.511 ± 0.047 R[SUB]⊕[/SUB] for HD 219134 c. These values suggest rocky compositions for both planets. Thanks to the proximity and the small size of their host star (0.778 ± 0.005 R[SUB]⊙[/SUB])[SUP]3[/SUP], these two transiting exoplanets — the nearest to the Earth yet found — are well suited for a detailed characterization (for example, precision of a few per cent on mass and radius, and constraints on the atmospheric properties) that could give important constraints on the nature and formation mechanism of the ubiquitous short-period planets of a few Earth masses. [less ▲]

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See detailLinking Forest Cover to Water Quality: A Multivariate Analysis of Large Monitoring Datasets
Brogna, Delphine; Michez, Adrien ULiege; Jacobs, Sander et al

in Water (2017), 9(3), 176

Forested catchments are generally assumed to provide higher quality water. However, this hypothesis must be validated in various contexts as interactions between multiple land use and land cover (LULC ... [more ▼]

Forested catchments are generally assumed to provide higher quality water. However, this hypothesis must be validated in various contexts as interactions between multiple land use and land cover (LULC) types, ecological variables and water quality variables render this relationship highly complex. This paper applies a straightforward multivariate approach on a typical large monitoring dataset of a highly managed and densely populated area (Wallonia, Belgium; 10-year dataset), quantifying forest cover effects on nine physico-chemical water quality variables. Results show that forest cover explains about one third of the variability of water quality and is positively correlated with higher quality water. When controlling for spatial autocorrelation, forest cover still explains 9% of water quality. Unlike needle-leaved forest cover, broad-leaved forest cover presents an independent effect from ecological variables and explains independently 4.8% of water quality variability while it shares 5.8% with cropland cover. This study demonstrates clear independent effects of forest cover on water quality, and presents a method to tease out independent LULC effects from typical large multivariate monitoring datasets. Further research on explanatory variables, spatial distribution effects and water quality datasets could lead to effective strategies to mitigate pollution and reach legal targets. [less ▲]

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See detailPhotosynthetic trichomes contain a specific Rubisco with a modified pH9 dependent activity
Laterre, Raphaëlle; Pottier, Mathieu; Remacle, Claire ULiege et al

in Plant Physiology (2017)

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See detailPouvoir politique et audace des juges
Grandjean, Geoffrey ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2017), (1), 231-237

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See detailLes peuplements à bouleau en forêt wallonne: reflet de la sylviculture du 20ème siècle
Dubois, Héloïse ULiege; Latte, Nicolas ULiege; Claessens, Hugues ULiege

in FORÊT.NATURE (2017), 142

Le bouleau est présent sous des formes diverses dans nos forêts. La place qu’il occupe en forêt wallonne est souvent le reflet d’une méconnaissance et du peu d’estime que lui portaient les sylviculteurs ... [more ▼]

Le bouleau est présent sous des formes diverses dans nos forêts. La place qu’il occupe en forêt wallonne est souvent le reflet d’une méconnaissance et du peu d’estime que lui portaient les sylviculteurs. Par une typologie des peuplements, l’article fait le tri parmi les contextes où se trouve le bouleau et discute de leurs potentialités sylvicoles dans un contexte changeant qui pourrait faire la part belle à cette essence vigoureuse et aux atouts variés. [less ▲]

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See detailH0LiCOW. VI. Testing the fidelity of lensed quasar host galaxy reconstruction
Ding, Xuheng; Liao, Kai; Treu, Tommaso et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

The empirical correlation between the mass of a supermassive black hole (M_BH) and its host galaxy properties is widely considered to be an evidence of their co-evolution. A powerful way to test the co ... [more ▼]

The empirical correlation between the mass of a supermassive black hole (M_BH) and its host galaxy properties is widely considered to be an evidence of their co-evolution. A powerful way to test the co-evolution scenario and learn about the feedback processes linking galaxies and nuclear activity is to measure these correlations as a function of redshift. Unfortunately, currently M_BH can only be estimated in active galaxies at cosmological distances. At these distances, bright active galactic nuclei (AGNs) can outshine the host galaxy, making it extremely difficult to measure the host's luminosity. Strongly lensed AGNs provide in principle a great opportunity to improve the sensitivity and accuracy of the host galaxy luminosity measurements as the host galaxy is magnified and more easily separated from the point source, provided the lens model is sufficiently accurate. In order to measure the M_BH-L correlation with strong lensing, it is necessary to ensure that the lens modelling is accurate, and that the host galaxy luminosity can be recovered to at least a precision and accuracy better than that of the typical M_BH measurement. We carry out extensive and realistic simulations of deep Hubble Space Telescope observations of lensed AGNs obtained by our collaboration. We show that the host galaxy luminosity can be recovered with better accuracy and precision than the typical uncertainty in M_BH(˜0.5 dex) for hosts as faint as 2-4 mag dimmer than the AGN itself. Our simulations will be used to estimate bias and uncertainties in the actual measurements to be presented in a future paper. [less ▲]

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See detailLa déprédation non aléatoire chez les oiseaux granivores du marais de Kagogo-Gisumo au Burundi
Nasasagare, Régine-Pacis; Ndayisaba, Ernest; Libois, Roland ULiege

in Bulletin scientifique sur l'environnement et la biodiversité (2017), 2

This study was conducted in order to show the role of environmental factors in the damage caused by birds on rice. In the Kagogo-Gisumo marsh, 20 plots were chosen randomly for a ornithological inventory ... [more ▼]

This study was conducted in order to show the role of environmental factors in the damage caused by birds on rice. In the Kagogo-Gisumo marsh, 20 plots were chosen randomly for a ornithological inventory and an evaluation of the losses due to the birds. This study revealed that environmental factors play an important role in bird damage to rice [less ▲]

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See detailL'acte d'imagination: Approches phénoménologiques
Hagelstein, Maud ULiege; Hervy, Alievtina ULiege; Leclercq, Bruno ULiege

in Bulletin d'Analyse Phénoménologique (2017), 13 (2017)(2),

Du 25 au 29 avril 2016, le centre « Phénoménologies » de l’Université de Liège a tenu la dixième édition de son séminaire international de recherche en phénoménologie. Autour du thème général L’Acte ... [more ▼]

Du 25 au 29 avril 2016, le centre « Phénoménologies » de l’Université de Liège a tenu la dixième édition de son séminaire international de recherche en phénoménologie. Autour du thème général L’Acte d’imagination : approches phénoménologiques, vingt-huit chercheurs issus de vingt-deux universités différentes se sont rencontrés pendant une semaine entière pour discuter dans le détail plusieurs aspects de la problématique. Le volume actuel reprend la plupart des communications qui avaient été présentées durant cette semaine, communications ici retravaillées pour intégrer les propositions qu’avaient suscitées leur présentation originale et plus généralement l’ensemble des débats très riches qu’avait permis la constitution ponctuelle d’une vraie communauté philosophique. Kant avait notoirement fait de la faculté d’imagination un intermédiaire (un peu indécis) entre la réceptivité de l’expérience sensible et la spontanéité de l’entendement. En s’installant plus nettement sur le terrain de la psychologie descriptive et en abandonnant le vocabulaire des « facultés » pour lui préférer celui des actes mentaux ou des fonctions psychiques, les brentaniens s’étaient donné les moyens d’analyser plus finement les composantes de l’acte d’imagination (mode de visée, contenu réel, contenu intentionnel...), les rapports de fondation qu’il entretient avec d’autres types d’actes, et par là le rôle qu’il peut jouer dans les fonctions cognitives ou évaluatives de l’esprit. C’est de cet acte d’imagination, envisagé par la phénoménologie en tant que psychologie descriptive, qu’il sera ici question. [less ▲]

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See detailEndothelial miRNAs as Cellular Messengers in Cardiometabolic Diseases.
Njock, Makon-Sébastien ULiege; Fish, Jason E.

in Trends in endocrinology and metabolism: TEM (2017), 28(3), 237-246

Metabolic syndrome is a clustering of risk factors that increases susceptibility to serious cardiometabolic complications, including type 2 diabetes (T2D) and myocardial infarction. Understanding the ... [more ▼]

Metabolic syndrome is a clustering of risk factors that increases susceptibility to serious cardiometabolic complications, including type 2 diabetes (T2D) and myocardial infarction. Understanding the underlying mechanisms will advance the development of diagnostic and therapeutic approaches. A prominent feature of cardiometabolic diseases is endothelial dysfunction. Endothelial cell (EC) homeostasis and response to pathological stimuli are controlled by gene regulatory networks in which miRNAs play a critical role. Recently, miRNAs have been implicated as cell-cell messengers that can influence cellular function. This review investigates the known and potential roles for miRNA-based cell-cell communication in the control of cardiovascular health and explores the value of identifying miRNA biomarkers and developing therapeutics that harness or antagonize miRNA-based communication. [less ▲]

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See detailEvaluation of different in vitro dissolution tests based on level A in vitro–in vivo correlations for fenofibrate self-emulsifying lipid-based formulations
Pestieau, Aude ULiege; Lebrun, Sonia; Cahay, Bernard et al

in European Journal of Pharmaceutics & Biopharmaceutics (2017), 112

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See detailComment les vidéastes gagnent-ils leur vie sur Youtube ?
Krywicki, Boris ULiege

in Culture, le Magazine Culturel de l'Université de Liège (2017)

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See detailOptimization of DNA extraction from the Algerian traditional date’s product “Btana”
Abekhti, Abdel; Dgeghati, S.; Taminiau, Bernard ULiege et al

in Applied Biology in Saharan Areas (2017), 1(1), 23-32

Btana is traditional preservation method that can sustain date’s supply during many years in comparaison to the commercial storage methods. However no scientific informations are available about ... [more ▼]

Btana is traditional preservation method that can sustain date’s supply during many years in comparaison to the commercial storage methods. However no scientific informations are available about biological factors that contribute to the successful of this method. Bacterial communities are a major key in preservation of many foods. Culture independent techniques are the most powerful tools to enhance bacterial diversity studies, but their efficiencies start with DNA extraction step. Therefore we have studied 3 protocols of DNA extraction from 11 Btana samples to evaluate their yield in total microbial DNA recovery. Protocols were based on a commercial kit DNeasy (QIAGEN, Germany) and two modified CTAB extraction methods (combined CTAB-DNeasy protocol, modified CTAB protocol) using polyvinyl pyrrolidone (PVP) and treatment with high salt solution (5M NaCl). Protocols were compared for quantity of DNA extracted using NanoDrop® ND-1000 Spectrophotometer and quality of DNA by 260/280 nm absorption ratio. The total extracted DNA was cheeked by PCR amplification of the 16S rRNA and visualized by electrophoresis on agarose gel (0.8%). Results showed that CTAB modified method provide the best DNA yield; however purification with NucleoSpin® Kit (Clontech, UK) was mostly needed for amplifying the DNA template. DNeasy kit protocol gave an amplified high quality DNA, but poor yields were obtained from date samples [less ▲]

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See detailThe Future Prevalence of Sarcopenia in Europe: A Claim for Public Health Action.
Ethgen, Olivier ULiege; Beaudart, Charlotte ULiege; Buckinx, Fanny ULiege et al

in Calcified Tissue International (2017), 100(3), 229-234

Sarcopenia is a major public health issue. To convince health policy makers of the emergency to invest in the sarcopenia field, it is of critical importance to produce reliable figures of the expected ... [more ▼]

Sarcopenia is a major public health issue. To convince health policy makers of the emergency to invest in the sarcopenia field, it is of critical importance to produce reliable figures of the expected burden of sarcopenia in the coming years. Age- and gender-specific population projections were retrieved until 2045 from the Eurostat online database (28 European countries). Age- and gender-specific prevalences of sarcopenia were interpolated from a study that compared prevalence estimates according to the different diagnostic cutoffs of the EWGSOP proposed definition. The reported prevalence estimates were interpolated between 65 and 100 years. Interpolated age- and gender-specific estimates of sarcopenia prevalence were then applied to population projections until 2045. Using the definition providing the lowest prevalence estimates, the number of individuals with sarcopenia would rise in Europe from 10,869,527 in 2016 to 18,735,173 in 2045 (a 72.4% increase). This corresponds to an overall prevalence of sarcopenia in the elderly rising from 11.1% in 2016 to 12.9% in 2045. With the definition providing the highest prevalence estimates, the number of individuals with sarcopenia would rise from 19,740,527 in 2016 to 32,338,990 in 2045 (a 63.8% increase), corresponding to overall prevalence rates in the elderly of 20.2% and 22.3% for 2016 and 2045, respectively. We showed that the number of sarcopenic patients will dramatically increase in the next 30 years, making consequences of muscle wasting a major public health issue. [less ▲]

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See detailInactivation of the β(1,2)-xylosyltransferase and the α(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 cells by a multiplex CRISPR/Cas9 strategy results in glycoproteins without plant-specific glycans
Mercx, Sébastien; Smargiasso, Nicolas ULiege; Chaumont, François et al

in Frontiers in Plant Science (2017), 8

Plants or plant cells can be used to produce pharmacological glycoproteins such as antibodies or vaccines. However these proteins carry N-glycans with planttypical residues [β(1,2)-xylose and core α(1,3 ... [more ▼]

Plants or plant cells can be used to produce pharmacological glycoproteins such as antibodies or vaccines. However these proteins carry N-glycans with planttypical residues [β(1,2)-xylose and core α(1,3)-fucose], which can greatly impact the immunogenicity, allergenicity, or activity of the protein. Two enzymes are responsible for the addition of plant-specific glycans: β(1,2)-xylosyltransferase (XylT) and α(1,3)- fucosyltransferase (FucT). Our aim consisted of knocking-out two XylT genes and four FucT genes (12 alleles altogether) in Nicotiana tabacum BY-2 suspension cells using CRISPR/Cas9. Three XylT and six FucT sgRNAs were designed to target conserved regions. After transformation of N. tabacum BY-2 cells with genes coding for sgRNAs, Cas9, and a selectable marker (bar), transgenic lines were obtained and their extracellular as well as intracellular protein complements were analyzed by Western blotting using antibodies recognizing β(1,2)-xylose and α(1,3)-fucose. Three lines showed a strong reduction of β(1,2)-xylose and α(1,3)-fucose, while two lines were completely devoid of them, indicating complete gene inactivation. The absence of these carbohydrates was confirmed by mass spectrometry analysis of the extracellular proteins. PCR amplification and sequencing of the targeted region indicated small INDEL and/or deletions between the target sites. The KO lines did not show any particular morphology and grew as the wild-type. One KO line was transformed with genes encoding a human IgG2 antibody. The IgG2 expression level was as high as in a control transformant which had not been glycoengineered. The IgG glycosylation profile determined by mass spectrometry confirmed that no β(1,2)-xylose or α(1,3)-fucose were present on the glycosylation moiety and that the dominant glycoform was the GnGn structure. These data represent an important step toward humanizing the glycosylation of pharmacological proteins expressed in N. tabacum BY-2 cells. © 2017 Mercx, Smargiasso, Chaumont, De Pauw, Boutry and Navarre. [less ▲]

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See detailEnglish translation and validation of the SarQoL®, a quality of life questionnaire specific for sarcopenia
Beaudart, Charlotte ULiege; Edwards, Mark; Moss, Charlotte et al

in Age & Ageing (2017), 46(2), 271-7

Background: the first quality of life questionnaire specific to sarcopenia, the SarQoL®, has recently been developed and validated in French. To extend the availability and utilisation of this ... [more ▼]

Background: the first quality of life questionnaire specific to sarcopenia, the SarQoL®, has recently been developed and validated in French. To extend the availability and utilisation of this questionnaire, its translation and validation in other languages is necessary. Objective: the purpose of this study was therefore to translate the SarQoL® into English and validate the psychometric properties of this new version. Design: cross-sectional. Setting: Hertfordshire, UK. Subjects: in total, 404 participants of the Hertfordshire Cohort Study, UK. Methods: the translation part was articulated in five stages: (i) two initial translations from French to English; (ii) synthesis of the two translations; (iii) backward translations; (iv) expert committee to compare the backward translations with the original questionnaire and (v) pre-test. To validate the English SarQoL®, we assessed its validity (discriminative power, construct validity), reliability (internal consistency, test–retest reliability) and floor/ceiling effects. Results: the SarQoL® questionnaire was translated without any major difficulties. Results indicated a good discriminative power (lower score of quality of life for sarcopenic subjects, P = 0.01), high internal consistency (Cronbach’s alpha of 0.88), consistent construct validity (high correlations found with domains related to mobility, usual activities, vitality, physical function and low correlations with domains related to anxiety, self-care, mental health and social problems) and excellent test–retest reliability (intraclass coefficient correlation of 0.95, 95%CI 0.92–0.97). Moreover, no floor/ceiling has been found. Conclusions: a valid SarQoL® English questionnaire is now available and can be used with confidence to better assess the disease burden associated with sarcopenia. It could also be used as a treatment outcome indicator in research. [less ▲]

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See detailEtude de la composition chimique et de l’activité antioxydante des différents extraits de la Lavande dentée (Lavandula dentata)
Bettaieb Rebey, I.; Bourgou, S.; Saidani Tounsi, M. et al

in Journal of New Sciences Agri & Biotech (2017), 39(2), 2096-2105

In this study, Lavandula dentata organs (roots, stems and leaves) were investigated for their essential oils, total phenolics, flavonoids contents and antioxidant activities. Essential oil yields were 0 ... [more ▼]

In this study, Lavandula dentata organs (roots, stems and leaves) were investigated for their essential oils, total phenolics, flavonoids contents and antioxidant activities. Essential oil yields were 0.22% in roots, 0.68 % in stems and 0.89 % in flowers. Major components of the oils were β-ocimene, limonene and 1,8 cineol in roots, stems and leaves and flowers, respectively. In all organs, total phenolics content ranged from 42.57 to 16.17 mg gallic acid equivalents per gram of dry weight (mg GAE/g DW).The antioxidant activities of Lavandula dentata extracts obtained from the three organs were assessed using two tests (DPPH and reducing power). The root extract was strongly effective as DPPH radical scavenger and reducing agent. Thus, the identification of individual target polyphenolic compounds of roots was performed by RP-HPLC. The major phenolic compound detected in roots was rosmarinic acid. This activity was high enough for the plant to be a new and natural source of strongly antioxidant substances for use as natural additives in food and pharmaceutical industry. [less ▲]

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See detail5-Fluorouracil degradation rate could predict toxicity in stages II-III colorectal cancer patients undergoing adjuvant FOLFOX
ONESTI, Concetta Elisa ULiege; Botticelli, Andrea; La Torre, Marco et al

in Anti-Cancer Drugs (2017), 28(3), 322-326

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See detailPublic Health impact and economic evaluation of vitamin D-fortified dairy products for fracture prevention in France.
HILIGSMANN, M.; BURLET, N.; FARDELLONE, P. et al

in Osteoporosis International (2017), 28(3), 833-840

Summary: The recommended intake of vitamin D-fortified dairy products can substantially decrease the burden of osteoporotic fractures and seems an economically beneficial strategy in the general French ... [more ▼]

Summary: The recommended intake of vitamin D-fortified dairy products can substantially decrease the burden of osteoporotic fractures and seems an economically beneficial strategy in the general French population aged over 60 years. Introduction: This study aims to assess the public health and economic impact of vitamin D-fortified dairy products in the general French population aged over 60 years. Methods: We estimated the lifetime health impacts expressed in number of fractures prevented, life years gained, and quality-adjusted life years (QALY) gained of the recommended intake of dairy products in the general French population over 60 years for 1 year (2015). A validated microsimulation model was used to simulate three age cohorts for both women and men (60–69, 70–79, and >80 years). The incremental cost per QALY gained of vitamin D-fortified dairy products compared to the absence of appropriate intake was estimated in different populations, assuming the cost of two dairy products per day in base case. Results: The total lifetime number of fractures decreased by 64,932 for the recommended intake of dairy products in the general population over 60 years, of which 46,472 and 18,460 occurred in women and men, respectively. In particular, 15,087 and 4413 hip fractures could be prevented in women and men. Vitamin D-fortified dairy products also resulted in 32,569 QALYs and 29,169 life years gained. The cost per QALY gained of appropriate dairy intake was estimated at €58,244 and fall below a threshold of €30,000 per QALY gained in women over 70 years and in men over 80 years. Conclusion: Vitamin D-fortified dairy products have the potential to substantially reduce the burden of osteoporotic fractures in France and seem an economically beneficial strategy, especially in the general population aged above 70 years. [less ▲]

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See detailAnalytical and clinical validation of the new Abbot Architect 25(OH)D assay: fit for purpose?
Cavalier, Etienne ULiege; LUKAS, Pierre ULiege; BEKAERT, Anne-Catherine ULiege et al

in Clinical Chemistry & Laboratory Medicine (2017), 55(3), 378-384

BACKGROUND: We provide a clinical and analytical evaluation of the reformulated version of the Abbott Architect 25-hydroxyvitamin D assay. We compared this assay with three commercial automated ... [more ▼]

BACKGROUND: We provide a clinical and analytical evaluation of the reformulated version of the Abbott Architect 25-hydroxyvitamin D assay. We compared this assay with three commercial automated immunoassays and against a VDSP-traceable liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in six different populations. We also supplemented 40 healthy volunteers with either 600,000 IU of vitamin D2 or 100,000 of vitamin D3 to evaluate the performance of the immunoassays vs. the LC-MS/MS. METHODS: Precision and limit of quantification were assessed, 25(OH)D2 and C3-epimer recovery were calculated. Two hundred and forty samples obtained in healthy Caucasians and Africans, osteoporotic, hemodialyzed and intensive care patients and 3rd trimester pregnant women were analyzed by all methods. Correlation was studied using Passing-Bablok and Bland-Altman analysis. Concordance correlation coefficient (CCC) was calculated to evaluate agreement between immunoassays and LC-MS/MS. We verified if patients were homogeneously classified with the immunoassays when they took vitamin D2 or vitamin D3 after 1, 7 and 28 days. RESULTS: We observed excellent analytical features and showed a very good correlation to the LC-MS/MS results in the overall population. Compared to the other immunoassays, concordance of the new Abbott assay with the LC-MS/MS was at least similar, and often better in diseased populations. Althought the cross-reactivity with 25(OH)D2 was not of 100%, there was no significant difference in the classifications of the patients, either supplemented with D2 or D3 or after 7 or 28 days. CONCLUSIONS: This modified version of the Abbott Architect assay is clearly improved compared to the previous one and presents a better agreement with the LC-MS/MS. [less ▲]

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See detailTrois frontières, deux langues. Un manuel allemand pour apprendre le français aux Belges germanophones
Schmets, Marine ULiege

in Vivre le Français : Revue de l'Association Belge des Professeurs de Français (2017), 252

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