References of "Scientific journals"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 1001 to 1100 of 62767     6 7 8 9 10 11 12 13 14 15 16     La baisse des taux d’intérêt influence-t-elle la valeur des entreprises?Streel, Alexandre ; Meunier, Virginiein Actualité Comptable et Archives Online (2017), 17Detailed reference viewed: 11 (0 ULiège) Sunlight irradiance and habituation of visual evoked potentials in migraine: The environment makes its markLisicki Martinez, Marco ; D'Ostilio, Kevin; Erpicum, Michel et alin Cephalalgia : An International Journal of Headache (2017)Background Migraine is a complex multifactorial disease that arises from the interaction between a genetic predisposition and an enabling environment. Habituation is considered as a fundamental adaptive ... [more ▼]Background Migraine is a complex multifactorial disease that arises from the interaction between a genetic predisposition and an enabling environment. Habituation is considered as a fundamental adaptive behaviour of the nervous system that is often impaired in migraine populations. Given that migraineurs are hypersensitive to light, and that light deprivation is able to induce functional changes in the visual cortex recognizable through visual evoked potentials habituation testing, we hypothesized that regional sunlight irradiance levels could influence the results of visual evoked potentials habituation studies performed in different locations worldwide. Methods We searched the literature for visual evoked potentials habituation studies comparing healthy volunteers and episodic migraine patients and correlated their results with levels of local solar radiation. Results After reviewing the literature, 26 studies involving 1291 participants matched our inclusion criteria. Deficient visual evoked potentials habituation in episodic migraine patients was reported in 19 studies. Mean yearly sunlight irradiance was significantly higher in locations of studies reporting deficient habituation. Correlation analyses suggested that visual evoked potentials habituation decreases with increasing sunlight irradiance in migraine without aura patients. Conclusion Results from this hypothesis generating analysis suggest that variations in sunlight irradiance may induce adaptive modifications in visual processing systems that could be reflected in visual evoked potentials habituation, and thus partially account for the difference in results between studies performed in geographically distant centers. Other causal factors such as genetic differences could also play a role, and therefore well-designed prospective trials are warranted. [less ▲]Detailed reference viewed: 35 (4 ULiège) Enjeux de la notion de genre en sémiotiqueBadir, Sémir in Semiotica (2017)What is a genre? Applied to the textual domain, this question has received a descriptive answer in language studies. Genres would thus be dis- tinguished from one another through formal (syntactic and ... [more ▼]What is a genre? Applied to the textual domain, this question has received a descriptive answer in language studies. Genres would thus be dis- tinguished from one another through formal (syntactic and lexical) traits and specific enunciative markers, as well as through the specificities of punctuation on the layout. Such response presupposes a global model where genres assem- ble texts (that actually undergo analysis) and are in turn integrated into dis- course. I question this model in the name of empiricism: genres, as governed by usage, do not allow for such integration. Genres are heterogeneous by nature and their description cannot be rigid. The reason is that genres are a product of a certain type of interpretative practice of texts and, beyond texts, of all sorts of works. The aim of this study is to show how genre is the categorization that corresponds to a hermeneutics of appropriation and, in this sense, is reluctant to being disclosed through a formal description. Greimas seems never to have doubted this, since his semiotic project was precisely centered in the neutraliza- tion of generic categories. [less ▲]Detailed reference viewed: 35 (6 ULiège) Communication of healthcare professionals: is there ageism?Schroyen, Sarah ; Adam, Stéphane ; Marquet, Manon et alin European Journal of Cancer Care (2017)Elderspeak is often used when talking to older individuals and is characterized by a slower and/or louder speech, a patronizing tone, etc. A part of the reason of such communication can be found in the ... [more ▼]Elderspeak is often used when talking to older individuals and is characterized by a slower and/or louder speech, a patronizing tone, etc. A part of the reason of such communication can be found in the actual context of negative view of aging. However, the link between view of aging and elderspeak has never been objectively studied in oncology. Therefore, 40 healthcare professionals (physicians and medical students) record a podcast where they have to explain an endocrine therapy to two fictional patients (40 vs 70 years old). Results show that when participants explained the treatment to the older patient, they used shorter utterances and made more repetitions. They also evoked fewer side effects such as sexual issues. Moreover, reduction of length of utterances and of word-per-minute rate was observed for older patient when participants have a positive view of aging but for both patients when they have a negative view of aging. In conclusion, physicians and medical students used elderspeak when they explained a treatment to older patients. Participants with a more negative view of aging also unconsciously talked slower and made shorter utterances to a 40 year-old patient. [less ▲]Detailed reference viewed: 40 (17 ULiège) Evaluating Model Simulations of Twentieth-Century Sea Level Rise. Part 2: Regional Sea-Level ChangesMeyssignac, B.; Slangen, A.; Melet, A. et alin Journal of Climate (2017), in pressTwentieth century regional sea-level changes are estimated from 12 climate models from the 5th phase of the Climate Model Intercomparison Project (CMIP5). The output of the CMIP5 climate model simulations ... [more ▼]Twentieth century regional sea-level changes are estimated from 12 climate models from the 5th phase of the Climate Model Intercomparison Project (CMIP5). The output of the CMIP5 climate model simulations were used to calculate the global and regional sea-level changes associated with dynamic sea level, atmospheric loading, glacier mass changes and ice sheet surface mass balance contributions. The contribution from groundwater depletion, reservoir storage and dynamic ice sheet mass changes are estimated from observations as they are not simulated by climate models. All contributions are summed, including the GIA contribution, and compared to observational estimates from 27 tide gauge records over the twentieth century (1900-2015). We find a general agreement between the simulated sea level and tide gauge records in terms of inter-annual to multi-decadal variability over 1900-2015. But climate models tend to systematically underestimate the observed sea-level trends, particularly in the first half of the 20th century. The corrections based on attributable biases between observations and models that have been identified in the part-1-paper, result in an improved explanation of the spatial variability in observed sea-level trends by climate models. Climate models show that the spatial variability in sea-level trends observed by tide-gauge records is dominated by the GIA contribution and the steric contribution over 1900-2015. Climate models also show that it is important to include all contributions to sea-level changes as they cause significant local deviations; for example, the groundwater depletion around India which is responsible for the low 20th century sea-level rise in the region. [less ▲]Detailed reference viewed: 30 (3 ULiège) Tcf7l2 plays pleiotropic roles in the control of glucose homeostasis, pancreas morphology, vascularization and regeneration.Facchinello, Nicola; Tarifeño-Saldivia, Estefania; Grisan, Enrico et alin Scientific Reports (2017), 7(1), 9605Detailed reference viewed: 10 (1 ULiège) Fusion-based Additive Manufacturing for Processing Aluminum Alloys: State-of-the-Art and ChallengesMertens, Anne ; Delahaye, Jocelyn ; Lecomte-Beckers, Jacqueline et alin Advanced Engineering Materials (2017), 19(8), 1700003Starting early 2015, the fusion-based additive manufacturing of Al alloys has been developing at an ever faster pace after undergoing a comparatively slow start with respect to other metallic materials ... [more ▼]Starting early 2015, the fusion-based additive manufacturing of Al alloys has been developing at an ever faster pace after undergoing a comparatively slow start with respect to other metallic materials. This paper reviews the recent developments with the aim of identifying major challenges and opportunities for future work. Laser Beam Melting proves the most useful technique for the additive fabrication of Al components with strongly out-of-equilibrium microstructures and potentially enhanced mechanical behavior. Laser Cladding is also promising for specific applications such as repairs and coatings. However, a deeper understanding of the thermal history during fabrication is still needed to further optimize the microstructures and usage properties. The design of new high strength alloys and of Al-matrix composites, and the development of better adapted post-processing procedures to take greater advantage of the specificities of fusion-based additive techniques are two other important issues in view of reaching the full potential of additive Al components. [less ▲]Detailed reference viewed: 126 (18 ULiège) Experimental and theoretical investigation of SrFe12O19 nanopowder for permanent magnet applicationAbraime, Brahim; Ait tamerd, Mohamed; Mahmoud, Abdelfattah et alin Ceramics International (2017)Strontium M-type hexagonal ferrites were synthesized at different calcination temperatures (800 °C, 1000 °C and 1100 °C) using sol-gel autocombustion method. Thermogravimetric analysis (TGA), X-ray ... [more ▼]Strontium M-type hexagonal ferrites were synthesized at different calcination temperatures (800 °C, 1000 °C and 1100 °C) using sol-gel autocombustion method. Thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), Mössbauer spectroscopy (MS) and superconducting quantum interference device magnetometer (SQUID) techniques were used to characterize crystal structure, phase composition, morphology and magnetic properties. TGA gives T = 800 °C as beginning of suitable calcination. Hexaferrite structure of single phase is obtained according to XRD results for all samples with crystallite size between 28 nm and 35 nm. SEM images show the growth of grain size with increasing of annealing temperature. (BH)max is calculated based on SQUID results and shows an enhancement between T = 800 °C and T = 1000 °C of 25%. The magnetic properties observed at low temperature are explained and confirmed by ab-initio calculations [less ▲]Detailed reference viewed: 37 (4 ULiège) Split-Band Interferometry-Assisted Phase Unwrapping for the Phase Ambiguities CorrectionLibert, Ludivine ; De Rauw, Dominique ; d'Oreye, Nicolas et alin Remote Sensing (2017), 9(9), Split-Band Interferometry (SBInSAR) exploits the large range bandwidth of the new generation of synthetic aperture radar (SAR) sensors to process images at subrange bandwidth. Its application to an ... [more ▼]Split-Band Interferometry (SBInSAR) exploits the large range bandwidth of the new generation of synthetic aperture radar (SAR) sensors to process images at subrange bandwidth. Its application to an interferometric pair leads to several lower resolution interferograms of the same scene with slightly shifted central frequencies. When SBInSAR is applied to frequency-persistent scatterers, the linear trend of the phase through the stack of interferograms can be used to perform absolute and spatially independent phase unwrapping. While the height computation has been the main concern of studies on SBInSAR so far, we propose instead to use it to assist conventional phase unwrapping. During phase unwrapping, phase ambiguities are introduced when parts of the interferogram are separately unwrapped. The proposed method reduces the phase ambiguities so that the phase can be connected between separately unwrapped regions. The approach is tested on a pair of TerraSAR-X spotlight images of Copahue volcano, Argentina. In this framework, we propose two new criteria for the frequency-persistent scatterers detection, based respectively on the standard deviation of the slope of the linear regression and on the phase variance stability, and we compare them to the multifrequency phase error. Both new criteria appear to be more suited to our approach than the multifrequency phase error. We validate the SBInSAR-assisted phase unwrapping method by artificially splitting a continuous phase region into disconnected subzones. Despite the decorrelation and the steep topography affecting the volcanic test region, the expected phase ambiguities are successfully recovered whatever the chosen criterion to detect the frequency-persistent scatterers. Comparing the aspect ratio of the distributions of the computed phase ambiguities, the analysis shows that the phase variance stability is the most efficient criterion to select stable targets and the slope standard deviation gives satisfactory results. [less ▲]Detailed reference viewed: 32 (9 ULiège) Preservation protocol for dimethylsulfoniopropionate and dimethylsulfoxide analysis in plant material of the Mediterranean seagrass Posidonia oceanica, and re-evaluation of dimethylsulfoniopropionate leaf contentBorges, Alberto ; Champenois, Willy in Aquatic Botany (2017), 143CWe tested three treatments to preserve Posidonia oceanica leaves for the analysis of dimethylsulfoniopropionate (DMSP) and dimethylsulfoxide (DMSO): oven dried at 60 °C for 24 h, frozen at −20 °C, and ... [more ▼]We tested three treatments to preserve Posidonia oceanica leaves for the analysis of dimethylsulfoniopropionate (DMSP) and dimethylsulfoxide (DMSO): oven dried at 60 °C for 24 h, frozen at −20 °C, and frozen-in-ice and kept at −20 °C. The DMSP content was analyzed by proxy as dimethylsulfide (DMS) by gas chromatography after alkaline cleavage at room-temperature. The DMSP leaf content of P. oceanica in samples that were oven dried at 60 °C for 24 h, then stored at room temperature decreased by 87% over 80 days of storage and then remained stable for about 88 additional days compared to the control. The DMSO leaf content of P. oceanica in samples that were oven dried increased nine-fold after 198 days of storage following drying compared to the control. Both the DMSP and DMSO leaf content of P. oceanica remained stable for 198 days compared to the control with frozen and frozen-in-ice treatments, which we both recommend as adequate protocols to preserve P. oceanica tissues for DMS(P,O) analysis. The annual average DMSP leaf content of P. oceanica at 10 m in the Bay of Calvi (Corsica, France) was 205 ± 58 μmol g−1 (fresh weight) based on samples preserved frozen, two orders of magnitude higher than the value we previously reported based on samples that were oven dried. The newly determined DMSP leaf content allows ranking P. oceanica as the highest DMSP producer reported to date among marine and inter-tidal autotrophs. [less ▲]Detailed reference viewed: 34 (10 ULiège) In vitro aggregating β-lactamase-polyQ chimeras do not induce toxic effects in an in vivo Caenorhabditis elegans modelVan Assche, Roel; Borghgraef, Charline; Vaneyck, Jonathan et alin Journal of Negative Results in BioMedicine (2017)Detailed reference viewed: 11 (2 ULiège) In vivo chlorophyll fluorescence screening allows the isolation of a Chlamydomonas mutant defective for NDUFAF3, an assembly factor involved in mitochondrial complex I assemblyMassoz, Simon; Hanikenne, Marc ; Bailleul, Benjamin et alin Plant Journal (The) (2017), 17(8), 2045-2054The qualitative screening method to select complex I mutants in the microalga Chlamydomonas, based on reduced growth under heterotrophic condition, is not suited for high throughput screening. In order to ... [more ▼]The qualitative screening method to select complex I mutants in the microalga Chlamydomonas, based on reduced growth under heterotrophic condition, is not suited for high throughput screening. In order to develop a fast screening method based on measurements of chlorophyll fluorescence, we first demonstrated that complex I mutants displayed decreased photosystem II efficiency in the genetic background of a photosynthetic mutation leading to reduced formation of the electrochemical proton gradient in the chloroplast (pgrl1 mutation). In contrast, single mutants (complex I and pgrl1 mutants) could not be distinguished from wild type by their photosystem II efficiency in the tested conditions. We next performed an insertional mutagenesis on the pgrl1 mutant. Out of ~3000 hygromycin-resistant insertional transformants, 46 had decreased photosystem II efficiency and three were complex I mutants. One of the mutants was tagged and whole genome sequencing identified the resistance cassette in NDUFAF3, a homolog of the human NDUFAF3 gene, encoding for an assembly factor involved in complex I assembly. Complemented strains showed restored complex I activity and assembly. Overall, we described here a screening method which is fast and particularly suited for identification of Chlamydomonas complex I mutants. [less ▲]Detailed reference viewed: 31 (5 ULiège) Microbiological stability of rice tart stored at ambient temperature after bakingN'guessan, Elise; Cissé, Mohamed; Niyonzima, Eugene et alin Journal of Food Research (2017), 6(5), 41-49Very popular in Belgium, rice tart is a hot pastry sold in bakeries. It is then consumed at home, for dessert or snack. This study is conducted to investigate the microbiological stability of this ... [more ▼]Very popular in Belgium, rice tart is a hot pastry sold in bakeries. It is then consumed at home, for dessert or snack. This study is conducted to investigate the microbiological stability of this foodstuff, from the end of baking to end user by consumers. In this purpose, 108 rice tart samples were collected from each of seven bakeries in five Belgium provinces. Physico-chimical analysis in addition to microbiological analysis were carried out in accordance with the European Regulation EC 2073/2005 and with references methods, to enumerate the total microorganisms count, Staphylococcus aureus, Bacillus cereus as well as Enterobacteria, susceptible likely to contaminate the tarts during the production or after baking. Even when the results meet the microbiological safety standards immediately after baking in all bakeries implicated, a significant (p <0,05) increase of mesophilic aerobic bacteria (ranging from <1 to 7 log cfu/g) and B. cereus (> 3,7 log cfu/g) was observed during the storage at non refrigerated temperature (28 to 30°C). A post-baking recontamination and other parameters like an insufficient baking time or a non uniform distribution of the oven heat could explain the observed bacteria growth. The present study shows that most rice tarts investigated are microbiologically safe. However, the possible increase of bacteria load in this foodstuff attributable to the favorable aw, pH and temperature conditions, highlight the importance of applying good hygienic practices and compliance with storage conditions after baking to ensure consumer safety. [less ▲]Detailed reference viewed: 19 (3 ULiège) Nanofitin as a New Molecular-Imaging Agent for the Diagnosis of 2 Epidermal Growth Factor Receptor Over-Expressing Tumors.Goux, Marine; Becker, Guillaume ; Gorré, Harmony et alin Bioconjugate Chemistry (2017), 28(9), 2361-2371Epidermal growth-factor receptor (EGFR) is involved in cell growth and proliferation and is over-expressed in malignant tissues. Although anti-EGFR-based immunotherapy became a standard of care for ... [more ▼]Epidermal growth-factor receptor (EGFR) is involved in cell growth and proliferation and is over-expressed in malignant tissues. Although anti-EGFR-based immunotherapy became a standard of care for patients with EGFR-positive tumors, this strategy of addressing cancer tumors by targeting EGFR with monoclonal antibodies is less-developed for patient diagnostic and monitoring. Indeed, antibodies exhibit a slow blood clearance, which is detrimental for positron emission tomography (PET) imaging. New molecular probes are proposed to overcome such limitations for patient monitoring, making use of low-molecular-weight protein scaffolds as alternatives to antibodies, such as Nanofitins with better pharmacokinetic profiles. Anti-EGFR Nanofitin B10 was reformatted by genetic engineering to exhibit a unique cysteine moiety at its C-terminus, which allows the development of a fast and site-specific radiolabeling procedure with 18F−4-fluorobenzamido-N-ethylamino-maleimide (18F−FBEM). The in vivo tumor targeting and imaging profile of the anti-EGFR Cys−B10 Nanofitin was investigated in a double-tumor xenograft model by static small-animal PET at 2 h after tail-vein injection of the radiolabeled Nanofitin 18F−FBEM−Cys−B10. The image showed that the EGFR- positive tumor (A431) is clearly delineated in comparison to the EGFR-negative tumor (H520) with a significant tumor-to-background contrast. 18F−FBEM−Cys−B10 demonstrated a significantly higher retention in A431 tumors than in H520 tumors at 2.5 h post-injection with a A431-to-H520 uptake ratio of 2.53 ± 0.18 and a tumor-to-blood ratio of 4.55 ± 0.63. This study provides the first report of Nanofitin scaffold used as a targeted PET radiotracer for in vivo imaging of EGFR-positive tumor, with the anti-EGFR B10 Nanofitin used as proof-of-concept. The fast generation of specific Nanofitins via a fully in vitro selection process, together with the excellent imaging features of the Nanofitin scaffold, could facilitate the development of valuable PET-based companion diagnostics. [less ▲]Detailed reference viewed: 28 (8 ULiège) Effect of genetic European taurine ancestry on milk yield of Ankole-Holstein crossbred dairy cattle in mixed smallholders system of Burundi highlandsManirakiza, Josiane; Hatungumukama, Gilbert; Thévenon, S. et alin Animal Genetics (2017), 48(5), 544-550Detailed reference viewed: 18 (2 ULiège) CO2-sourced α-alkylidene cyclic carbonates: a Step forward in the quest for functional regioregular poly(urethane)s and poly(carbonate)sGennen, Sandro ; Grignard, Bruno ; Tassaing, Thierry et alin Angewandte Chemie International Edition (2017), 56(35), 1039410398We describe a robust platform for the synthesis of a large diversity of novel functional CO2 -sourced polymers by exploiting the regio-controlled and site selective ring-opening of α- alkylidene ... [more ▼]We describe a robust platform for the synthesis of a large diversity of novel functional CO2 -sourced polymers by exploiting the regio-controlled and site selective ring-opening of α- alkylidene carbonates by various nucleophiles. The remarkable reactivity of α-alkylidene carbonates is dictated by the exocyclic olefinic group that selectively orients the cyclic carbonate ring- opening with the formation of an enol species. The polyaddition of CO2 -sourced bis-α-alkylidene carbonates (bis-αCCs) with primary and secondary diamines provides novel regioregular functional poly(urethane)s. The reactivity of bis-αCCs is also exploited for producing new poly(β-oxo-carbonate)s by organocatalyzed polyaddition with a diol. All polyadditions were feasible under ambient conditions. This synthesis platform provides new functional variants of world-class leading polymers families (polyurethanes, polycarbonates) and valorises CO2 as a chemical feedstock. [less ▲]Detailed reference viewed: 71 (23 ULiège) Biology, Flowering and Fruiting of the Cactus Opuntia spp.: A Review and Some Observations on Three Varieties in MoroccoArba, Mohamed ; Falisse, André ; Choukr-Allah, Redouane et alin Brazilian Archives of Biology and Technology (2017), 60The cactus is a succulent plant resistant to droughts. According to the recently reviewed classification, cacti belong to the family of Opuntiaceae Desv. (synon. Cactaceae Juss.) with Opuntia Mill. as the ... [more ▼]The cactus is a succulent plant resistant to droughts. According to the recently reviewed classification, cacti belong to the family of Opuntiaceae Desv. (synon. Cactaceae Juss.) with Opuntia Mill. as the typical genus. This genus is economically the most important in the family, as it includes a group of cactus pear plants which play an important role in the agricultural systems of arid and semi-arid regions. Flowering of the cactus pear fruit is an important determinant of the fruit harvesting period. The goal of this paper is to present the physiology of the cactus pear and to explain in detail the biology of its flowering and fruiting processes. This study is also enriched by our observations on the flowering and fruiting of three varieties of cactus pear that we followed for two successive years in southern Morocco. [less ▲]Detailed reference viewed: 21 (3 ULiège) Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in ratsTarasco, Erika; Seebeck, Petra; Pfundstein, Svende et alin Endocrine (2017)Somatostatin analogs are widely used to treat conditions associated with hormonal hypersecretion such as acromegaly and metastatic neuroendocrine tumors. First generation somatostatin analogs, such as ... [more ▼]Somatostatin analogs are widely used to treat conditions associated with hormonal hypersecretion such as acromegaly and metastatic neuroendocrine tumors. First generation somatostatin analogs, such as octreotide and lanreotide, have high affinity for somatostatin receptor subtype 2 (SSTR2), but have incomplete efficacy in many patients. Pasireotide targets multiple SSTRs, having the highest affinity for SSTR5, but causes hyperglycemia and diabetes mellitus in preclinical and clinical studies. AP102 is a new somatostatin analogs with high affinity at both SSTR2 and SSTR5. We aimed to characterize the effects of AP102 vs. pasireotide on random and dynamic glucose levels, glucoregulatory hormone concentrations and growth axis measures in healthy Sprague-Dawley rats. [less ▲]Detailed reference viewed: 23 (2 ULiège) Supercritical Fluid Chromatography in Traditional Chinese Medicine AnalysisHuang, Yang ; Tang, Guangyun; Zhang, Tingting et alin Journal of Pharmaceutical and Biomedical Analysis (2017)Traditional Chinese medicines (TCMs) are gaining increasing popularity throughout the world due to their long historical clinical practices. Highly efficient analytical separation tools are essential for ... [more ▼]Traditional Chinese medicines (TCMs) are gaining increasing popularity throughout the world due to their long historical clinical practices. Highly efficient analytical separation tools are essential for investigating the mysterious properties of TCMs and their quality control. Supercritical fluid chromatography (SFC) showed a great potential in TCM analysis for both nonpolar and polar components. In this paper, an overview of the experimental conditions (i.e. detection mode, stationary phase, mobile phase composition, pressure and temperature) used in SFC for achiral separations of TCM components is presented and recent applications to the analysis of different classes of compounds extracted from TCMs, such as lipids, terpene and terpenoids, phenolic compounds, flavonoids, alkaloids, saponins and carbohydrates, will be briefly described. [less ▲]Detailed reference viewed: 24 (3 ULiège) Le cercle de lecture, un dispositif pour construire ensemble des compétences de lecteurs et d'enseignantsScheepers, Caroline ; Outers, Pierre ; Werner, Anne-Catherine et alin Didactiques en Pratique (2017)Comment accompagner les premiers pas des stagiaires débutants ? À cette vaste et complexe question, le présent article envisage d’apporter un très modeste éclairage. Ainsi, sera décrit, conceptualisé ... [more ▼]Comment accompagner les premiers pas des stagiaires débutants ? À cette vaste et complexe question, le présent article envisage d’apporter un très modeste éclairage. Ainsi, sera décrit, conceptualisé, analysé et discuté un projet collaboratif qui a associé étroitement théorie et pratique, université et école secondaire, expérimentation et transposition d’un dispositif, didactique disciplinaire et didactique générale. Plus concrètement, il s’est agi de faire expérimenter en tant qu’apprenants un cercle de lecture et un atelier d’écriture par les étudiants romanistes qui suivent le cours de première année de master centré sur la didactique du français langue première, avant de les inviter à transposer l’outil ainsi testé dans leur classe de stage. Seront prises en compte différentes traces : nos consignes, les journaux de stage, les portfolios, les consignes des étudiants, les traces recueillies auprès des élèves du secondaire, les rapports des maitres de stage, etc. Nous verrons in fine que le processus mis en place confirme, toutes proportions gardées, la validité et la pertinence du principe d’homologie entre les activités testées par les stagiaires lors de leur formation initiale à l’université et celles que les formateurs leur recommandent de mettre en œuvre dans leurs classes. [less ▲]Detailed reference viewed: 39 (5 ULiège) Protein–polysaccharide complexes for enhanced protein delivery in hyaluronic acid templated calcium carbonate microparticlesRamalapa, Bathabile ; Crasson, Oscar ; Vandevenne, Marylène et alin Journal of Materials Chemistry B (2017), 5The controlled delivery of proteins within calcium carbonate (CaCO3) particles is currently widely investigated. The success of these carriers is driven by ionic interactions between the encapsulated ... [more ▼]The controlled delivery of proteins within calcium carbonate (CaCO3) particles is currently widely investigated. The success of these carriers is driven by ionic interactions between the encapsulated proteins and the particles. This poses a great limitation on the successful loading of proteins that have no ionic affinity to CaCO3. In this study, we explored the use of polysaccharide–protein interactions to strongly enhance the encapsulation of proteins in CaCO3 microparticles. Previously, Vandevenne and colleagues inserted a human chitin binding domain (ChBD) that has intrinsic affinity for hyaluronic acid (HA) into a β-lactamase (BlaP). This generated chimeric protein, named BlaPChBD, was shown to be fully bifunctional. In this study we showed that this hybrid protein can associate with HA and be successfully loaded into vaterite CaCO3 microparticles using supercritical CO2 (ScCO2) technology aided by the templating effect of HA on CaCO3. The presence of ChBD inserted into BlaP increased the encapsulation of the protein by 6-fold when complexed with HA. Furthermore, thrombin cleavage sites were engineered on both sides of the inserted ChBD in the chimeric BlaP to achieve release of the protein from the microparticles by protease cleavage. Our results showed that thrombin cleavage increased the release of the protein from the microparticles within 36 hours from <20% to 87%. In conclusion, the presence of ChBD successfully improved the encapsulation yield of the protein while retaining up to 82% of its activity and efficient release of the protein from the microparticles was achieved by protease cleavage. [less ▲]Detailed reference viewed: 30 (16 ULiège) Complete mitogenome sequence of Ricasolia amplissima (Lobariaceae) reveals extensive mitochondrial DNA rearrangement within the Peltigerales (lichenized ascomycetes)Simon, Antoine ; Liu, Yang; Sérusiaux, Emmanuël et alin Bryologist (2017), 120(3), 335-339The structure of mitochondrial genomes varies among non-lichenized fungi in terms of their genic and intronic content and genic order. Whether lichenized fungal mitogenomes are equally labile is unknown ... [more ▼]The structure of mitochondrial genomes varies among non-lichenized fungi in terms of their genic and intronic content and genic order. Whether lichenized fungal mitogenomes are equally labile is unknown due to the paucity of available mitogenomes. We assembled the mitogenome of Ricasolia amplissima (Peltigerales, Lobariaceae), using massive parallel sequencing, and compared its structure to that of two species of Peltigera (Peltigeraceae). The mitochondrial genome of R. amplissima comprised 82,333 bp, with a 29.8% G+C content, and holds 15 unique protein-coding genes, 29 tRNA genes, two rRNA genes, and one non-coding RNA gene. Although the protein-coding gene content in the mitogenome of Peltigera and Ricasolia was identical, the relative gene order differed substantially, revealing that significant gene rearrangements also characterize the evolution of mitogenomes of lichenized ascomycetes at a relatively shallow phylogenetic depth, such as within the order Peltigerales. [less ▲]Detailed reference viewed: 37 (12 ULiège) A central role for Type I IFN in Th2 response induction by dendritic cellsWebb, Lauren M.; Lundie, Rachel J.; Borger, Jessica G. et alin EMBO Journal (2017), 36(16), 2404-2418Detailed reference viewed: 23 (4 ULiège) 3D thermal finite element analysis of laser cladding processed Ti-6Al-4V part with microstructural correlationsTran, Hoang Son ; Tchuindjang, Jérôme Tchoufack ; Paydas, Hakan et alin Materials & Design (2017), 128In this study, a 3D thermal model of laser cladding by powder injection applied to Ti-6Al-4V is developed. The manufactured part is made of a Ti-6Al-4V substrate on which successive layers of laser melted ... [more ▼]In this study, a 3D thermal model of laser cladding by powder injection applied to Ti-6Al-4V is developed. The manufactured part is made of a Ti-6Al-4V substrate on which successive layers of laser melted powder are added, leading to a thick deposit. The computed temperature field and its time evolution are compared to experimental measurements. The temperature distribution in the substrate allows the prediction of the depths of the melt pool and the heat affected zone. Correlations between simulated thermal histories and the final microstructure in the thick deposit are established, leading to the enhancement of a dynamic shift of the critical transformation points due to high thermal rates during laser processing. The nature of the phases present within the deposit is discussed. [less ▲]Detailed reference viewed: 78 (30 ULiège) Strategies for replacing non-invasive brain stimulation sessions: recommendations for designing neurostimulation clinical trials.Thibaut, Aurore ; O'brien, Athony; Frefni, Felipein Expert Review of Medical Devices (2017)Despite the potential impact of missed visits on the outcomes of neuromodulation treatments, it is not clear how this issue has been addressed in clinical trials. Given this gap in the literature, we ... [more ▼]Despite the potential impact of missed visits on the outcomes of neuromodulation treatments, it is not clear how this issue has been addressed in clinical trials. Given this gap in the literature, we reviewed articles on non-invasive brain stimulation in participants with depression or chronic pain, and investigated how missed visits were handled. Areas covered: We performed a search on PUBMED/MEDLINE using the keywords: 'tDCS', 'transcranial direct current stimulation', 'transcranial magnetic stimulation', 'depression', and 'pain'. We included studies with a minimum of five participants who were diagnosed with depression or chronic pain, who underwent a minimum of five tDCS or TMS sessions. A total of 181 studies matched our inclusion criteria, 112 on depression and 69 on chronic pain. Of these, only fifteen (8%) articles reported or had a protocol addressing missed visits. This review demonstrates that, in most of the trials, there is no reported plan to handle missed visits. Expert commentary: Based on our findings and previous studies, we developed suggestions on how to handle missed visits in neuromodulation protocols. A maximum of 20% of missing sessions should be allowed before excluding a patient and these sessions should be replaced at the end of the stimulation period. [less ▲]Detailed reference viewed: 11 (0 ULiège) Administrative Change in the EU: a Cross-Country Empirical Study on the Contextual Determinants of NPM Reform RhetoricEsposito, Giovanni ; Gaeta, Giuseppe Lucio; Trasciani, Giorgiain Annals of Public and Cooperative Economics (2017), 88(3), 323344Framed within the paradigm of New Public Management (NPM), structural reforms in the EU aimed at modernizing the public administrations of Member States (MSs) have long since been a priority area of the ... [more ▼]Framed within the paradigm of New Public Management (NPM), structural reforms in the EU aimed at modernizing the public administrations of Member States (MSs) have long since been a priority area of the EU’s economic policy. Since the 1990s, these reforms have been sharply intensified across European countries with the declared purpose of enhancing economy, efficiency and effectiveness in their national public sectors’ organizations. In line with the European Commission’s recent research initiatives in search for novel quantitative data on NPM in the EU, this paper studies European parties’ NPM reform rhetoric. More specifically, it investigates the MSs’ institutional, economic and political context within which parties have declared their intention of reforming national administrative systems. Thus, it sheds light on the MSs’ domestic factors that are associated with the diffusion of the NPM values across the political discourse of EU’s national parties. [less ▲]Detailed reference viewed: 43 (15 ULiège) Phosphatases and solid tumors: focus on glioblastoma initiation, progression and recurrencesDedobbeleer, Matthias ; Willems, Estelle; Freeman, Stephen et alin Biochemical Journal (2017), 474(17), 2903-2924Phosphatases and cancer have been related for many years now, as these enzymes regulate key cellular functions, including cell survival, migration, differentiation and proliferation. Dysfunctions or ... [more ▼]Phosphatases and cancer have been related for many years now, as these enzymes regulate key cellular functions, including cell survival, migration, differentiation and proliferation. Dysfunctions or mutations affecting these enzymes have been demonstrated to be key factors for oncogenesis. The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A, CDC25 and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma. [less ▲]Detailed reference viewed: 12 (1 ULiège) Superparamagnetic colloids in viscous fluidsDarras, Alexis ; Opsomer, Eric ; Vandewalle, Nicolas et alin Scientific Reports (2017), 7The influence of a magnetic field on the aggregation process of superparamagnetic colloids has been well known on short time for a few decades. However, the influence of important parameters, such as ... [more ▼]The influence of a magnetic field on the aggregation process of superparamagnetic colloids has been well known on short time for a few decades. However, the influence of important parameters, such as viscosity of the liquid, has received only little attention. Moreover, the equilibrium state reached after a long time is still challenging on some aspects. Indeed, recent experimental measurements show deviations from pure analytical models in extreme conditions. Furthermore, current simulations would require several years of computing time to reach equilibrium state under those conditions. In the present paper, we show how viscosity influences the characteristic time of the aggregation process, with experimental measurements in agreement with previous theories on transient behaviour. Afterwards, we performed numerical simulations on equivalent systems with lower viscosities. Below a critical value of viscosity, a transition to a new aggregation regime is observed and analysed. We noticed this result can be used to reduce the numerical simulation time from several orders of magnitude, without modifying the intrinsic physical behaviour of the particles. However, it also implies that, for high magnetic fields, granular gases could have a very different behaviour from colloidal liquids. [less ▲]Detailed reference viewed: 55 (10 ULiège) Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitorsRondelet, Grégoire; Fleury, Laurence; Faux, Céline et alin Future Medicinal Chemistry (2017), 9(13), Aim: DNA methyltransferases (DNMTs) are important drug targets for epigenetic therapy of cancer. Nowadays, non-nucleoside DNMT inhibitors are in development to address high toxicity of nucleoside analogs ... [more ▼]Aim: DNA methyltransferases (DNMTs) are important drug targets for epigenetic therapy of cancer. Nowadays, non-nucleoside DNMT inhibitors are in development to address high toxicity of nucleoside analogs. However, these compounds still have low activity in cancer cells and mode of action of these compounds remains unclear. Materials & methods: In this work, we studied maleimide derivatives of RG108 by biochemical, structural and computational approaches to highlight their inhibition mechanism on DNMTs. Results: Findings demonstrated a correlation between cytotoxicity on mesothelioma cells of these compounds and their inhibitory potency against DNMTs. Noncovalent and covalent docking studies, supported by crystallographic (apo structure of M.HhaI) and differential scanning fluorimetry assays, provided detailed insights into their mode of action and revealed essential residues for the stabilization of such compounds inside DNMTs. [less ▲]Detailed reference viewed: 7 (1 ULiège) Mathematical modeling of extracorporeal CO2 removal therapy. A validation carried out on ten pigsHabran, Simon ; Desaive, Thomas ; MORIMONT, Philippe et alin Medical & Biological Engineering & Computing (2017)The extracorporeal CO2 removal device (ECCO2RD) is used in clinics to treat patients suffering from respiratory failures like acute respiratory distress syn- drome (ARDS) or chronic obstructive pulmonary ... [more ▼]The extracorporeal CO2 removal device (ECCO2RD) is used in clinics to treat patients suffering from respiratory failures like acute respiratory distress syn- drome (ARDS) or chronic obstructive pulmonary disease (COPD). The aim of this device is to decarboxylate blood externally with low blood flow. A mathematical model is proposed to describe protective ventilation, ARDS, and an extracorporeal CO2 removal therapy (ECCO2RT). The sim- ulations are compared with experimental data carried out on ten pigs. The results show a good agreement between the mathematical simulations and the experimental data, which provides a nice validation of the model. This model is thus able to predict the decrease of PCO2 during ECCO2RT for different blood flows across the extracorporeal lung support. [less ▲]Detailed reference viewed: 18 (4 ULiège) Impact of canopy aerodynamic distance spatial and temporal variability on long term eddy covariance measurementsHurdebise, Quentin ; Heinesch, Bernard ; De Ligne, Anne et alin Agricultural and Forest Meteorology (2017), 247(2017), 131-138Understanding if and how the spatial and temporal variability of the surrounding environment affects turbulence is essential for long-term eddy covariance measurements. It requires characterizing the ... [more ▼]Understanding if and how the spatial and temporal variability of the surrounding environment affects turbulence is essential for long-term eddy covariance measurements. It requires characterizing the surrounding environment. One way to achieve this is to analyse the canopy aerodynamic distance (Δ), which is the difference between measurement height (zm) and displacement height (d). In this work, an original method to estimate the canopy aerodynamic distance at a fine spatial (30° sectors) and temporal (one year) resolution was proposed. It was based on sensible heat cospectra analysis, calibrated on a measurement height change and validated using canopy height inventories. This method was applied to 20 years of eddy covariance measurements from the Vielsalm Terrestrial Observatory (VTO), a site located in a mixed temperate forest. The method allowed Δ spatio-temporal variability due to changes in canopy or measurement height to be detected. Relationships between Δ and turbulence statistics were then analysed: the momentum correlation coefficient (ruw) was found to be dependent on Δ, confirming that the measurements were made in the roughness sublayer of the atmospheric surface layer. In contrast, no such relationship was found sensible heat, CO2 or water vapour correlation coefficients, suggesting that the Δ variability did not affect significantly these fluxes. There were significant differences, however, between azimuthal directions, suggesting that these scalars were affected by forest heterogeneity in a different way. Various hypotheses were put forward to explain the differences and their relevance was evaluated. This study highlighted the need to consider the spatial and temporal variability of the surrounding environment in order to verify the consistency of long-term eddy covariance datasets. [less ▲]Detailed reference viewed: 42 (13 ULiège) Mild synthesis of poly(HEMA)-networks as well-defined nanoparticles in supercritical carbon dioxideParilti, Rahmet ; Alaimo, David; Grignard, Bruno et alin Journal of Materials Chemistry B (2017), 5(29), 5806-5815Free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate was carried out in supercritical carbon dioxide (scCO2) in the presence of stabilisers based on polyethylene oxide (PEO) and poly ... [more ▼]Free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate was carried out in supercritical carbon dioxide (scCO2) in the presence of stabilisers based on polyethylene oxide (PEO) and poly(heptadecafluorodecyl acrylate) (PFDA). Different architectures of copolymers (random, palm-tree and diblock) were tested for their surface tension, cloud point and as a stabilising agent. The diblock architecture was found to be the best candidate resulting in poly(HEMA) spherical particles with a size of 316 nm. Furthermore, the effect of the CO2-phobic block (PEO) in the diblock architecture was investigated by using three different chain lengths (1000, 2000, 5000 g mol−1). By optimizing the stabiliser composition and structure, mild reaction conditions have been identified allowing us to obtain well-defined spherical cross-linked poly(HEMA) particles with a mean diameter of unprecedented low size (216 nm) at a temperature as low as 35 °C. [less ▲]Detailed reference viewed: 55 (10 ULiège) Oviposition deterrent activity of basil plants and their essentials oils against Tuta absoluta (Lepidoptera: Gelechiidae)Yarou, Boni Barthélémy ; Bawin, Thomas; Boullis, Antoine et alin Environmental Science and Pollution Research (2017)The leafminer Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is one of the most important pests of tomato, reducing crop yields by up to 100% in greenhouses and fields, in several countries globally ... [more ▼]The leafminer Tuta absoluta Meyrick (Lepidoptera: Gelechiidae) is one of the most important pests of tomato, reducing crop yields by up to 100% in greenhouses and fields, in several countries globally. Because synthetic insecticides lead to resistance and have adverse effects on natural enemies and the health of producers, alternative control methods are needed. In this study, we assessed the oviposition-deterring effect of basil plants, Ocimum gratissimum L. and O. basilicum L. (Lamiaceae), using dual-choice behavioural assays performed in flight tunnels. We found that both plants significantly reduced T. absoluta oviposition behaviour on a tomato plant located nearby. To evaluate the potential effect of basil volatile organic compounds, we formulated essential oils of both plant species in paraffin oil, and observed a similar oviposition-deterring effect. Gas chromatography analyses detected 18 constituents in these essential oils which the major constituents included thymol (33.3%), p-cymene (20.4%), γ-terpinene (16.9%), myrcene (3.9%) in O. gratissimum and estragol (73.8%), linalool (8.6%), β-elemene (2.9%) and E-β-ocimene (2.6%) in O. basilicum. Twenty and 33 compounds were identified of the volatiles collected on O. gratissimum and O. basilicum plants, respectively. The main components include the following: p-cymene (33.5%), γ-terpinene (23.6%), α-terpinene (7.2%), α-thujene (6.7%) and E-α-bergamotene (38.9%) in O. gratissimum, and methyl eugenol (26.1%), E-β-ocimene (17.7%), and linalool (9.4%) in O. basilicum. Four compounds (α-pinene, β-pinene, Myrcene, Limonene) were common in essential oils and plants. Our results suggest the valuable potential of basil and associated essential oils as a component of integrated management strategies against the tomato leafminer. [less ▲]Detailed reference viewed: 54 (7 ULiège) Multiple-trait genomewide mapping and gene network analysis for scrotal circumference growth curves in Brahman cattle1Soares, A. C. C.; Guimarães, S. E. F.; Kelly, M. J. et alin Journal of Animal Science (2017), 95(8), 3331-3345Fertility traits are economically important in cattle breeding programs. Scrotal circumference (SC) measures are repeatable, easily obtained, highly heritable, and positively correlated with female ... [more ▼]Fertility traits are economically important in cattle breeding programs. Scrotal circumference (SC) measures are repeatable, easily obtained, highly heritable, and positively correlated with female fertility traits and sperm quality traits in males. A useful approach to summarize SC measures over time is using nonlinear models, which summarize specific measures of SC in a few parameters with biological interpretation. This approach facilitates the selection of bulls with larger SC and maturity index (K), that is, early maturing animals. Because SC is a sex-limited trait, identifying the underlying genomics of growth curve parameters will allow selection across both males and females. We reported the first multitrait genomewide association study (GWAS) of estimated growth curve parameters for SC data in Brahman cattle. Five widely used nonlinear models were tested to fit a total of 3,612 SC records, measured at 6, 12, 18, and 24 mo of age. The von Bertalanffy model, individually fitted for each animal, best fit this SC data. Parameter estimates SC at maturity (A) and K as well as SC at all ages were jointly analyzed in a GWAS to identify 1-Mb regions most strongly associated with each trait. Heritabilities were 0.25 for K and 0.32 for A and ranged from 0.51 to 0.72 for SC at 6 (SC6), 12 (SC12), 18 (SC18), and 24 mo of age (SC24). An overlapping window on chromosome 14 explaining around 0.8% of genetic variance for K, SC12, SC18, and SC24 was observed. The major positional candidate genes within 1 Mb upstream and downstream of this overlapping window were LYN, CHD7, RAB2A, and ARFGEF1. Windows of 1 Mb explaining more than 0.4% of each trait on chromosomes 1, 3, 6, 7, 14, 17, 18, 24, 25, and 26 were identified. Pathways and net-work analyses were indicated through transcription factors playing a role on fertility traits: SOX9, BRCA1, STAT3, NFE2L2, EGR1, PPARG, and NFKB1. Further validation studies on larger populations or other breeds are required to validate these findings and to improve our understanding of the biology and complex genetic architecture of traits associated with scrotal growth and male fertility in cattle. [less ▲]Detailed reference viewed: 17 (6 ULiège) The tails of the satellite auroral footprints at JupiterBonfond, Bertrand ; Saur, J.; Grodent, Denis et alin Journal of Geophysical Research. Space Physics (2017), 122The electro-magnetic interaction between Io, Europa and Ganymede and the rotating plasma that surrounds Jupiter has a signature in the aurora of the planet. This signature, called the satellite footprint ... [more ▼]The electro-magnetic interaction between Io, Europa and Ganymede and the rotating plasma that surrounds Jupiter has a signature in the aurora of the planet. This signature, called the satellite footprint, takes the form of a series of spots located slightly downstream of the feet of the field lines passing through the moon under consideration. In the case of Io, these spots are also followed by an extended tail in the downstream direction relative to the plasma flow encountering the moon. A few examples of a tail for the Europa footprint have also been reported in the northern hemisphere. Here we present a simplified Alfvénic model for footprint tails and simulations of vertical brightness profiles for various electron distribution, which favour such a model over quasi-static models. We also report here additional cases of Europa footprint tails, in both hemispheres, even though such detections are rare and difficult. Furthermore, we show that the Ganymede footprint can also be followed by a similar tail. Finally, we present a case of a 320° long Io footprint tail, while other cases in similar configurations do not display such a length. [less ▲]Detailed reference viewed: 47 (7 ULiège) Experimental and numerical investigation of the nonlinear dynamics of compliant mechanisms for deployable structuresDewalque, Florence ; Schwartz, Cédric ; Denoël, Vincent et alin Mechanical Systems & Signal Processing (2017), 101This paper studies the dynamics of tape springs which are characterised by a highly geometrical nonlinear behaviour including buckling, the formation of folds and hysteresis. An experimental set-up is ... [more ▼]This paper studies the dynamics of tape springs which are characterised by a highly geometrical nonlinear behaviour including buckling, the formation of folds and hysteresis. An experimental set-up is designed to capture these complex nonlinear phenomena. The experimental data are acquired by the means of a 3D motion analysis system combined with a synchronised force plate. Deployment tests show that the motion can be divided into three phases characterised by different types of folds, frequencies of oscillation and damping behaviours. Furthermore, the reproducibility quality of the dynamic and quasi-static results is validated by performing a large number of tests. In parallel, a nonlinear finite element model is developed. The required model parameters are identified based on simple experimental tests such as static deformed configurations and small amplitude vibration tests. In the end, the model proves to be well correlated with the experimental results in opposite sense bending, while in equal sense, both the experimental set-up and the numerical model are particularly sensitive to the initial conditions. [less ▲]Detailed reference viewed: 48 (2 ULiège) Phytosterols-induced viscoelasticity of oleogels prepared by using monoglyceridesBin Sintang, M.D.; Danthine, Sabine ; Brown, A. et alin Food Research International (2017), 100Monoglycerides (MGs) and phytosterols (PS) are known to form firm oleogels with liquid oil. However, the oleogels are prone to undergo polymorphic transition over time that lead to crystals' aggregation ... [more ▼]Monoglycerides (MGs) and phytosterols (PS) are known to form firm oleogels with liquid oil. However, the oleogels are prone to undergo polymorphic transition over time that lead to crystals' aggregation thus, compromises physical properties. Thus, we combined MGs with PS to control the crystallization and modify the morphology of the combination oleogels, as both components are reported to interact together. The oleogels were prepared at different ratio combinations and characterized in their rheological, thermal, morphology, and diffraction properties. The results showed that the 8:2 MGP:PS exhibited higher storage modulus (G′) than the MGP mono-component. The combination oleogels exhibited effects on the crystallization and polymorphic transition. Consequently, the effects led to change in the morphology of the combination oleogels which was visualized using optical and electron microscope. The resultant effect on the morphology is associated with crystal defect. Due to observable crystals of MGP and PS, it is speculated that the combination oleogels formed a mixed crystal system. This was confirmed with diffraction analysis in which the corresponding peaks from MGP and PS were observed in the combination oleogels. However, the 8:2 oleogel exhibited additional peak at 35.41 Å. Ultimately, the 8:2 was the optimum combination observed in our study. Interestingly, this combination is inspired by nature as sterols (phytosterols) are natural component of lipid membrane whilst MGP has properties similar to phospholipids. Hence, the results of our study not only beneficial for oil structuring, but also for the fields of biophysical and pharmaceutical. [less ▲]Detailed reference viewed: 6 (1 ULiège) The inner structure of early-type galaxies in the Illustris simulationXu, Dandan; Springel, Volker; Sluse, Dominique et alin Monthly Notices of the Royal Astronomical Society (2017), 469Early-type galaxies provide unique tests for the predictions of the cold dark matter cosmology and the baryonic physics assumptions entering models for galaxy formation. In this work, we use the Illustris ... [more ▼]Early-type galaxies provide unique tests for the predictions of the cold dark matter cosmology and the baryonic physics assumptions entering models for galaxy formation. In this work, we use the Illustris simulation to study correlations of three main properties of early-type galaxies, namely the stellar orbital anisotropies, the central dark matter fractions and the central radial density slopes, as well as their redshift evolution since z = 1.0. We find that lower mass galaxies or galaxies at higher redshift tend to be bluer in rest-frame colour, have higher central gas fractions, and feature more tangentially anisotropic orbits and steeper central density slopes than their higher mass or lower redshift counterparts, respectively. The projected central dark matter fraction within the effective radius shows a very mild mass dependence but positively correlates with galaxy effective radii due to the aperture effect. The central density slopes obtained by combining strong lensing measurements with single-aperture kinematics are found to differ from the true density slopes. We identify systematic biases in this measurement to be due to two common modelling assumptions, isotropic stellar orbital distributions and power-law density profiles. We also compare the properties of early-type galaxies in Illustris to those from existing galaxy and strong lensing surveys; we find in general broad agreement but also some tension, which poses a potential challenge to the stellar formation and feedback models adopted by the simulation. [less ▲]Detailed reference viewed: 17 (1 ULiège) Social sustainability assessments in the biobased economy: Towards a systemic approachRafiaani, Parisa ; Kuppens, Tom; Van Dael, Miet et alin Renewable & Sustainable Energy Reviews (2017)The majority of impact assessments for the biobased economy are primarily focused on the environmental and (techno-)economic aspects, while social aspects are rarely considered. This study proposes a ... [more ▼]The majority of impact assessments for the biobased economy are primarily focused on the environmental and (techno-)economic aspects, while social aspects are rarely considered. This study proposes a modified systemic approach for a social sustainability impact assessment of the biobased economy, based on a review on the common methodologies for assessing social impacts. Accordingly, the proposed approach follows the four general iterative steps of social life cycle analysis (SLCA) as it considers all life cycle phases of the biobased economy. The systemic approach considers the potential social impacts on local communities, workers, and consumers as the main three groups of the stakeholders. The review showed that the most common social indicators for inventory analysis within the biobased economy include health and safety, food security, income, employment, land- and worker-related concerns, energy security, profitability, and gender issues. Multi-criteria decision analysis (MCDA) was also highlighted as the broadly utilized methodology for aggregating the results of impact assessments within the biobased economy. Taking a life cycle perspective, this study provides a holistic view of the full sustainability of research, design, and innovation in the biobased economy by suggesting the integration of the social aspects with techno-economic and an environmental life cycle assessment. Our proposed systemic approach makes possible to integrate the social impacts that are highly valued by the affected stakeholders into the existing sustainability models that focus only on environmental and techno-economic aspects. We discuss the steps of the proposed systemic approach in order to identify the challenges of applying them within the biobased economy. These challenges refer mainly to the definition of the functional unit and system boundaries, the selection and the analysis of social indicators (inventory analysis), the aggregation of the inventory to impact categories, and the uncertainties associated with the social sustainability evaluation. The result of this review and the proposed systemic approach serve as a foundation for industry and policy makers to gain a better insight into the importance of social sustainability impacts assessment within the biobased economy. [less ▲]Detailed reference viewed: 53 (6 ULiège) A New Solar Spectrum from 656 to 3088 nmMeftah, M.; Damé, L.; Bolsée, D. et alin Solar Physics (2017), 292The solar spectrum is a key parameter for different scientific disciplines such as solar physics, climate research, and atmospheric physics. The SOLar SPECtrometer (SOLSPEC) instrument of the Solar ... [more ▼]The solar spectrum is a key parameter for different scientific disciplines such as solar physics, climate research, and atmospheric physics. The SOLar SPECtrometer (SOLSPEC) instrument of the Solar Monitoring Observatory (SOLAR) payload onboard the International Space Station (ISS) has been built to measure the solar spectral irradiance (SSI) from 165 to 3088 nm with high accuracy. To cover the full wavelength range, three double-monochromators with concave gratings are used. We present here a thorough analysis of the data from the third channel/double-monochromator, which covers the spectral range between 656 and 3088 nm. A new reference solar spectrum is therefore obtained in this mainly infrared wavelength range (656 to 3088 nm); it uses an absolute preflight calibration performed with the blackbody of the Physikalisch-Technische Bundesanstalt (PTB). An improved correction of temperature effects is also applied to the measurements using in-flight housekeeping temperature data of the instrument. The new solar spectrum (SOLAR-IR) is in good agreement with the ATmospheric Laboratory for Applications and Science (ATLAS 3) reference solar spectrum from 656 nm to about 1600 nm. However, above 1600 nm, it agrees better with solar reconstruction models than with spacecraft measurements. The new SOLAR/SOLSPEC measurement of solar spectral irradiance at about 1600 nm, corresponding to the minimum opacity of the solar photosphere, is 248.08 ± 4.98 mW m[SUP]-2[/SUP] nm[SUP]-1[/SUP] (1 σ), which is higher than recent ground-based evaluations. [less ▲]Detailed reference viewed: 20 (2 ULiège) The discoveries of WASP-91b, WASP-105b and WASP-107b: Two warm Jupiters and a planet in the transition region between ice giants and gas giantsAnderson, D. R.; Collier Cameron, A.; Delrez, L. et alin Astronomy and Astrophysics (2017), 604We report the discoveries of three transiting exoplanets. WASP-91b is a warm Jupiter (1.34 M[SUB]Jup[/SUB], 1.03 R[SUB]Jup[/SUB]) in a 2.8-day orbit around a metal-rich K3 star. WASP-105b is a warm ... [more ▼]We report the discoveries of three transiting exoplanets. WASP-91b is a warm Jupiter (1.34 M[SUB]Jup[/SUB], 1.03 R[SUB]Jup[/SUB]) in a 2.8-day orbit around a metal-rich K3 star. WASP-105b is a warm Jupiter (1.8 M[SUB]Jup[/SUB], 0.96 R[SUB]Jup[/SUB]) in a 7.9-day orbit around a metal-rich K2 star. WASP-107b is a warm super-Neptune/sub-Saturn (0.12 M[SUB]Jup[/SUB], 0.94 R[SUB]Jup[/SUB]) in a 5.7-day orbit around a solar-metallicity K6 star. Considering that giant planets seem to be more common around stars of higher metallicity and stars of higher mass, it is notable that the hosts are all metal-rich, late-type stars. With orbital separations that place both WASP-105b and WASP-107b in the weak-tide regime, measurements of the alignment between the planets' orbital axes and their stars' spin axes may help us to understand the inward migration of short-period, giant planets. The mass of WASP-107b (2.2 M[SUB]Nep[/SUB], 0.40 M[SUB]Sat[/SUB]) places it in the transition region between the ice giants and gas giants of the Solar System. Its radius of 0.94 R[SUB]Jup[/SUB] suggests that it is a low-mass gas giant with a H/He-dominated composition. The planet thus sets a lower limit of 2.2 M[SUB]Nep[/SUB] on the planetary mass above which large gaseous envelopes can be accreted and retained by proto-planets on their way to becoming gas giants. We may discover whether WASP-107b more closely resembles an ice giant or a gas giant by measuring its atmospheric metallicity via transmission spectroscopy, for which WASP-107b is a very good target. Based on observations made with: the WASP-South photometric survey instrument, the 0.6-m TRAPPIST robotic imager, and the EulerCam camera and the CORALIE spectrograph mounted on the 1.2-m Euler-Swiss telescope.The photometric time-series and radial-velocity data used in this work are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/604/A110 [less ▲]Detailed reference viewed: 28 (1 ULiège) Le rôle des petites entreprises du métier artisanal traditionnel dans le développement local: case d'étude dans le périphérie de HanoiNguyen, Thi Thu Hien ; Lebailly, Philippe ; Nguyen, Van Nghienin Science and Technology Journal of Agriculture & Rural Development (2017), 15Rural industrial development and new rural development programmes are the main target of Vietnam in the process of industrialization – modernization of the country. To expedite this process, it is ... [more ▼]Rural industrial development and new rural development programmes are the main target of Vietnam in the process of industrialization – modernization of the country. To expedite this process, it is necessary to promote the development and encourage the contributions of small enterprise in general and small enterprise rural in particular because practices in many countries show the important role of small and micro enterprises in local development. This paper presents the initial results of research to understand the economic–social contributions of rural enterprises to local development through the mobilization of local resources as well as establishment of the economic-social relations in local of rattan’s enterprises in the suburb of Hanoi, and then propose some measures to facilitate the operation of enterprises and promote the contribution of rattan’s enterprises for local development. [less ▲]Detailed reference viewed: 42 (4 ULiège) The EBLM project. III. A Saturn-size low-mass star at the hydrogen-burning limitvon Boetticher, Alexander; Triaud, Amaury H. M. J.; Queloz, Didier et alin Astronomy and Astrophysics (2017), 604We report the discovery of an eclipsing binary system with mass-ratio q ˜ 0.07. After identifying a periodic photometric signal received by WASP, we obtained CORALIE spectroscopic radial velocities and ... [more ▼]We report the discovery of an eclipsing binary system with mass-ratio q ˜ 0.07. After identifying a periodic photometric signal received by WASP, we obtained CORALIE spectroscopic radial velocities and follow-up light curves with the Euler and TRAPPIST telescopes. From a joint fit of these data we determine that EBLM J0555-57 consists of a sun-like primary star that is eclipsed by a low-mass companion, on a weakly eccentric 7.8-day orbit. Using a mass estimate for the primary star derived from stellar models, we determine a companion mass of 85 ± 4 M[SUB]Jup[/SUB] (0.081 M[SUB]⊙[/SUB]) and a radius of 0.84[SUP]+ 0.14[/SUP][SUB]-0.04[/SUB]R[SUB]Jup[/SUB] (0.084 R[SUB]⊙[/SUB]) that is comparable to that of Saturn. EBLM J0555-57Ab has a surface gravity log g[SUB]2[/SUB] =5.50[SUP]+ 0.03[/SUP][SUB]-0.13[/SUB] and is one of the densest non-stellar-remnant objects currently known. These measurements are consistent with models of low-mass stars. The photometry tables and radial velocities are only available at the CDS and on demand via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/604/L6 [less ▲]Detailed reference viewed: 26 (2 ULiège) Exergy analysis applied to performance of buildings in EuropeSartor, Kevin ; Dewallef, Pierre in Energy and Buildings (2017), 148Energy performance of buildings generally assesses the energy consumption of buildings such as heating, domestic heat water, ventilation systems, etc. However, this approach is based on the first law of ... [more ▼]Energy performance of buildings generally assesses the energy consumption of buildings such as heating, domestic heat water, ventilation systems, etc. However, this approach is based on the first law of thermodynamics and considers only the quantity of energy used without considering its ‘quality’ and leads to a lack of information about the energy conversion processes. This is particularly true in the new low-energy buildings where sometimes high temperatures sources are used to meet low-temperature needs. The exergy analysis of a system, based on first and second thermodynamic laws, can be used to overcome this. In this work, it is proposed to compare the energy and the exergy consumption and the related CO2 emissions of several kinds of buildings to determine the best systems in terms of energy and exergy needs. The energy demand calculations are performed using the official software available in Belgium and some assumptions are implemented to consider the exergy approach. As exergy calculations require a reference state, some different climatic conditions are also investigated. Finally, some conclusions are discussed to rank the sources of energy and their related exergy losses. [less ▲]Detailed reference viewed: 39 (9 ULiège) The Far Ultra-Violet Imager on the Icon MissionMende, Stephen; Frey, Harald; Rider, Kodi et alin Space Science Reviews (2017)ICON Far UltraViolet (FUV) imager contributes to the ICON science objectives by providing remote sensing measurements of the daytime and nighttime atmosphere/ ionosphere. During sunlit atmospheric ... [more ▼]ICON Far UltraViolet (FUV) imager contributes to the ICON science objectives by providing remote sensing measurements of the daytime and nighttime atmosphere/ ionosphere. During sunlit atmospheric conditions, ICON FUV images the limb altitude profile in the shortwave (SW) band at 135.6 nm and the longwave (LW) band at 157 nm perpendicular to the satellite motion to retrieve the atmospheric O/N2 ratio. In conditions of atmospheric darkness, ICON FUV measures the 135.6 nm recombination emission of O+ ions used to compute the nighttime ionospheric altitude distribution. ICON Far Ultra- Violet (FUV) imager is a Czerny–Turner design Spectrographic Imager with two exit slits and corresponding back imager cameras that produce two independent images in separate wavelength bands on two detectors. All observations will be processed as limb altitude profiles. In addition, the ionospheric 135.6 nm data will be processed as longitude and latitude spatial maps to obtain images of ion distributions around regions of equatorial spread F. The ICON FUV optic axis is pointed 20 degrees below local horizontal and has a steering mirror that allows the field of view to be steered up to 30 degrees forward and aft, to keep the local magnetic meridian in the field of view. The detectors are micro channel plate (MCP) intensified FUV tubes with the phosphor fiber-optically coupled to Charge Coupled Devices (CCDs). The dual stack MCP-s amplify the photoelectron signals to overcome the CCD noise and the rapidly scanned frames are co-added to digitally create 12-second integrated images. Digital on-board signal processing is used to compensate for geometric distortion and satellite motion and to achieve data compression. The instrument was originally aligned in visible light by using a special grating and visible cameras. Final alignment, functional and environmental testing and calibration were performed in a large vacuum chamber with a UV source. The test and calibration program showed that ICON FUV meets its design requirements and is ready to be launched on the ICON spacecraft. [less ▲]Detailed reference viewed: 40 (11 ULiège) First Report of Little cherry virus 1 affecting European Plum (Prunus domestica) in BelgiumTahzima, Rachid ; Foucart, Yoika; Peusens, Gertie et alin Plant Disease (2017), 101(8), 1557Little cherry disease (LChD), one of the major viral diseases of cherry worldwide, can be caused by two viruses (Little cherry virus 1 and 2), both Closteroviridae members. LChD has an important impact on ... [more ▼]Little cherry disease (LChD), one of the major viral diseases of cherry worldwide, can be caused by two viruses (Little cherry virus 1 and 2), both Closteroviridae members. LChD has an important impact on both yield and fruit quality in commercial sweet and sour cherry (Prunus avium L. and P. cerasus L.) (Ruiz-Garcia et al. 2016). LChV-1 (genus Velarivirus) is known to be graft-transmissible and is spread via infected propagated plant material, but no vector has been identified. For LChV-2 (genus Ampelovirus), at least two species of mealybugs (Hemiptera, Pseudococcidae) are known to transmit the virus, namely the apple mealybug (Phenacoccus aceris Signoret) and grape mealybug (Pseudococcus maritimus Ehrhorn). During two growing seasons (2013–15), intensive surveys were conducted in Belgium to monitor the incidence of LChD in sweet and sour cherries and in ornamental Prunus spp., revealing widespread occurrence of both LChV-1 and 2 (De Jonghe et al. 2016). In the close vicinity of a sweet cherry (P. avium cv. Coralise) orchard with an infection rate of 30% with LChV-1, plum (P. domestica L. cv. Opal) trees growing at the edge of a plum orchard and showing sporadic undetermined leaf symptoms such as premature leaf reddening and chlorosis were observed and sampled. RNA of leaves and roots collected from 50 plum trees was extracted using the Spectrum Total Plant RNA kit (Sigma-Aldrich, Machelen, Belgium) and tested using RT-PCR with LChV-1 specific primers as follows: LCUW7090 (5′-GGTTGTCCTCGGTTGATTAC-3′)/LCUWc7389 (5′-GGCTTGGTTCCATACATCTC-3′) (Bajet et al. 2008), amplifying a 300-bp fragment spanning the ORF1b encoding the RNA dependent RNA-polymerase (RdRp) gene and 1LC_12776F (5′-TCAAGAAAAGTTCTGGTGTGC-3′)/1LC_13223R (5′-CGAGCTAGACGTATCAGTATC-3′) (Nagyova et al. 2015), targeting a 456-bp fragment of the coat protein (CP) gene. The presence of LChV-1 was confirmed in 12% of the samples. Bidirectional sequencing (Macrogen, Amsterdam) was done for each LChV-1 amplicon. BLAST searches of the assembled sequences revealed a distinct variability between the Belgian plum and cherry isolates (8% and 6% divergence in the amplified RdRp and CP sequences, respectively) from the respective adjacent orchards, suggesting separate introduction events. RdRp gene sequences of the Belgian plum isolates (GenBank accession nos. KY173002 and KY173004) shared 99% identity with the Greek cherry (HG792418) and peach isolates (HG792399), while the Belgian cherry isolate (KY173001) showed 99% homology with the deposited RdRp gene sequences of the Greek cherry (HG792420, HG792398). Partial CP gene sequence of the Belgian plum isolates (KY173006, KY173008) were the closest to Italian ITMAR (EU715989) and German V2356 (JX669615) cherry isolates, sharing 96% and 94% identity, respectively. Further investigation is in progress to assess the importance of LChV natural host shift among Prunus spp., its epidemiology in propagation material, and its association with potential vectors. To our knowledge, this description of LChV-1 associated with P. domestica constitutes the first report in Belgium. [less ▲]Detailed reference viewed: 12 (2 ULiège) Proteomic and functional analyses of the virion transmembrane proteome of cyprinid herpesvirus 3.Vancsok, Catherine ; Penaranda, Ma Michelle D.; Raj, V. Stalin et alin Journal of Virology (2017), 91(21), Virion transmembrane proteins (VTPs) mediate key functions in the herpesvirus infectious cycle. Cyprinid herpesvirus 3 (CyHV-3) is the archetype of fish alloherpesviruses. The present study was devoted to ... [more ▼]Virion transmembrane proteins (VTPs) mediate key functions in the herpesvirus infectious cycle. Cyprinid herpesvirus 3 (CyHV-3) is the archetype of fish alloherpesviruses. The present study was devoted to CyHV-3 VTPs. Using mass spectrometry approaches, we identified 16 VTPs of the CyHV-3 FL strain. Mutagenesis experiments demonstrated that eight of these proteins are essential for viral growth in vitro (ORF32, ORF59, ORF81, ORF83, ORF99, ORF106, ORF115, and ORF131), and eight are non-essential (ORF25, ORF64, ORF65, ORF108, ORF132, ORF136, ORF148, and ORF149). Among the non-essential proteins, deletion of ORF25, ORF132, ORF136, ORF148, or ORF149 affects viral replication in vitro, and deletion of ORF25, ORF64, ORF108, ORF132, or ORF149 impacts plaque size. Lack of ORF148 or ORF25 causes attenuation in vivo to a minor or major extent, respectively. The safety and efficacy of a virus lacking ORF25 were compared to those of a previously described vaccine candidate deleted for ORF56 and ORF57 (Delta56-57). Using quantitative PCR, we demonstrated that the ORF25 deleted virus infects fish through skin infection and then spreads to internal organs as reported previously for the wild-type parental virus and the Delta56-57 virus. However, compared to the parental wild-type virus, the replication of the ORF25 deleted virus was reduced in intensity and duration to levels similar to those observed for the Delta56-57 virus. Vaccination of fish with a virus lacking ORF25 was safe but had low efficacy at the doses tested. This characterization of the virion transmembrane proteome of CyHV-3 provides a firm basis for further research on alloherpesvirus VTPs.IMPORTANCE Virion transmembrane proteins play key roles in the biology of herpesviruses. Cyprinid herpesvirus 3 (CyHV-3) is the archetype of fish alloherpesviruses and the causative agent of major economic losses in common and koi carp worldwide. In this study of the virion transmembrane proteome of CyHV-3, the major findings were: (i) the FL strain encodes 16 virion transmembrane proteins; (ii) eight of these proteins are essential for viral growth in vitro; (iii) seven of the non-essential proteins affect viral growth in vitro, and two affect virulence in vivo; and (iv) a mutant lacking ORF25 is highly attenuated but induces moderate immune protection. This study represents a major breakthrough in understanding the biology of CyHV-3 and will contribute to the development of prophylactic methods. It also provides a firm basis for the further research on alloherpesvirus virion transmembrane proteins. [less ▲]Detailed reference viewed: 22 (4 ULiège) Innovative polyelectrolytes/poly(ionic liquid)s for energy and environmentAjjan, Fátima N.; Ambrogi, Martina; Tiruye, Girum Ayalneh et alin Polymer International (2017), 66(8), 1119-1126This manuscript presents the work carried out within the European Project RENAISSANCE-ITN, which was dedicated to the development of innovative polyelectrolytes for energy and environmental applications ... [more ▼]This manuscript presents the work carried out within the European Project RENAISSANCE-ITN, which was dedicated to the development of innovative polyelectrolytes for energy and environmental applications. Within the project different types of innovative polyelectrolytes were synthesized such as poly(ionic liquid)s coming from renewable or natural ions, thiazolium cations, cathechol functionalities or from a new generation of cheap deep-eutectic monomers. Further, macromolecular architectures such as new poly(ionic liquid) block copolymers and new (semi)conducting polymer/polyelectrolyte complexes were also developed. As the final goal, the application of these innovative polymers in energy and environment was investigated. Important advances in energy storage technologies included the development of new carbonaceous materials, new lignin/conducting polymer biopolymer electrodes, new iongels and single-ion conducting polymer electrolytes for supercapacitors and batteries and new poly(ionic liquid) binders for batteries. On the other hand, the use of the innovative polyelectrolytes into sustainable environmental technologies led to the development of new liquid and dry water, new materials for water cleaning technologies such as floculants, oil absorbers, new recyclable organocatalysts platform and multifunctional polymer coatings with antifouling and antimicrobial properties. All in all this article demonstrates the potential of the poly(ionic liquid)s for high-value applications in Energy & Enviromental areas. [less ▲]Detailed reference viewed: 125 (25 ULiège) Assessment of Continuous Pain in Newborns admitted to NICUs in 18 European CountriesAnand, Kanwaljeet; Eriksson, Mats; Boyle, Elaine et alin Acta Paediatrica (2017), 106(8), 1248-59Aim: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown. Methods: A ... [more ▼]Aim: Continuous pain occurs routinely, even after invasive procedures, or inflammation and surgery, but clinical practices associated with assessments of continuous pain remain unknown. Methods: A prospective cohort study in 243 Neonatal Intensive Care Units (NICUs) from 18 European countries recorded frequency of pain assessments, use of mechanical ventilation, sedation, analgesia, or neuromuscular blockade for each neonate upto 28 days after NICU admission. Results: Only 2113/6648 (31·8%) of neonates received assessments of continuous pain, occurring variably among tracheal ventilation (TrV, 46·0%), noninvasive ventilation (NiV, 35· 0%), and no ventilation (NoV, 20· 1%) groups (p<0· 001). Daily assessments for continuous pain occurred in only 10·4% of all neonates (TrV: 14· 0%, NiV: 10· 7%, NoV: 7· 6%; p<0· 001). More frequent assessments of continuous pain occurred in NICUs with pain guidelines, nursing champions, and surgical admissions prompted (all p<0·01), and for newborns <32 weeks gestational age, those requiring ventilation, or opioids, sedatives-hypnotics, general anesthetics (O-SH-GA) (all p<0·001), or surgery (p=0· 028). Use of O-SH-GA drugs increased the odds for pain assessment in the TrV (OR:1· 60, p<0·001) and NiV groups (OR:1·40, p<0· 001). Conclusion: Assessments of continuous pain occurred in less than one-third of NICU admissions, and daily in only 10% of neonates. NICU clinical practices should consider including routine assessments of continuous pain in newborns. [less ▲]Detailed reference viewed: 23 (3 ULiège) Analysis of the non-Markovianity for electron transfer reactions in the oligothiophene-fullerene in an heterojunctionMangaud, Etienne; Meier, Christoph; Desouter, Michèle in Chemical Physics (2017), 494Detailed reference viewed: 9 (0 ULiège) Methylome and transcriptome profiling in Myasthenia Gravis monozygotic twins.Mamrut, Shimrat; Avidan, Nili; Truffault, Frederique et alin Journal of Autoimmunity (2017), 82OBJECTIVE: To identify novel genetic and epigenetic factors associated with Myasthenia gravis (MG) using an identical twins experimental study design. METHODS: The transcriptome and methylome of ... [more ▼]OBJECTIVE: To identify novel genetic and epigenetic factors associated with Myasthenia gravis (MG) using an identical twins experimental study design. METHODS: The transcriptome and methylome of peripheral monocytes were compared between monozygotic (MZ) twins discordant and concordant for MG, as well as with MG singletons and healthy controls, all females. Sets of differentially expressed genes and differentially methylated CpGs were validated using RT-PCR for expression and target bisulfite sequencing for methylation on additional samples. RESULTS: >100 differentially expressed genes and approximately 1800 differentially methylated CpGs were detected in peripheral monocytes between MG patients and controls. Several transcripts associated with immune homeostasis and inflammation resolution were reduced in MG patients. Only a relatively few genes differed between the discordant healthy and MG co-twins, and both their expression and methylation profiles demonstrated very high similarity. INTERPRETATION: This is the first study to characterize the DNA methylation profile in MG, and the expression profile of immune cells in MZ twins with MG. Results suggest that numerous small changes in gene expression or methylation might together contribute to disease. Impaired monocyte function in MG and decreased expression of genes associated with inflammation resolution could contribute to the chronicity of the disease. Findings may serve as potential new predictive biomarkers for disease and disease activity, as well as potential future targets for therapy development. The high similarity between the healthy and the MG discordant twins, suggests that a molecular signature might precede a clinical phenotype, and that genetic predisposition may have a stronger contribution to disease than previously assumed. [less ▲]Detailed reference viewed: 6 (1 ULiège) Hydrothermal synthesis in presence of carbon black: Particle-size reduction of iron hydroxyl phosphate hydrate for Li-ion batteryKaregeya, Claude ; Mahmoud, Abdelfattah ; Cloots, Rudi et alin Electrochimica Acta (2017), 250Iron hydroxyl phosphate hydrate Fe1.19(PO4)(OH)0.57(H2O)0.43 (FPHH) was obtained by hydrothermal synthesis at 220 °C for 6 hours. Addition of carbon black to the solution before hydrothermal treatment led ... [more ▼]Iron hydroxyl phosphate hydrate Fe1.19(PO4)(OH)0.57(H2O)0.43 (FPHH) was obtained by hydrothermal synthesis at 220 °C for 6 hours. Addition of carbon black to the solution before hydrothermal treatment led to a reduction of the FPHH particle size from ∼10 μm in the carbon-free compound to ∼300–500 nm in the FPHH-10%C and FPHH-20%C composite with a good dispersion of conducting carbon black. X-ray diffraction, 57Fe Mossbauer spectroscopy and a thermal decomposition study showed that the addition of carbon black did not interfere with the formation of the FPHH phase. Thanks to its favorable microstructural characteristics, the FPHH-10%C and FPHH-20%C material exhibited good performance as positive electrode for Li-ion battery, with high initial discharge capacities of 150, 128 and 112 mAh g−1 at 0.25C, 0.5C and 1C rates respectively and 99% capacity retention after 150 cycles at 2C. These results show that addition of solid carbon directly into the solution prior to hydrothermal treatment is a simple and effective way to reduce particle size and also to improve electronic conductivity by dispersing conductive carbon around the active material. This approach is easily transferable to other compounds prepared by hydrothermal synthesis, in order to control particle size while retaining the advantage of crystallization at low temperature. [less ▲]Detailed reference viewed: 40 (6 ULiège) « Oser sauver à l’école » : Mise en place d’un cycle de premier secours au cours d’éducation physiqueCollin, Manon ; Cloes, Marc ; Laurent, Charlotte et alin Didactiques en Pratique (2017), 3En Europe et aux États-Unis, plus de 700 000 personnes décèdent chaque année des suites d’un arrêt cardiaque (Berdowski et al. 2010). Avec un taux de survie de 2 à 10 % (European Resuscitation Council ... [more ▼]En Europe et aux États-Unis, plus de 700 000 personnes décèdent chaque année des suites d’un arrêt cardiaque (Berdowski et al. 2010). Avec un taux de survie de 2 à 10 % (European Resuscitation Council, 2015), le pronostic vital associé aux arrêts cardiaques est, dès lors, relativement limité. Celui-ci peut être cinq à sept fois supérieur si un témoin pratique une réanimation cardio-pulmonaire (RCP) et une défibrillation durant les premières minutes d’intervention (ERC, 2015). Dans le cadre de cette étude pilote, l’objectif était d’analyser la pertinence, l’impact et la faisabilité de la mise en place d’un cycle de premiers secours dans un contexte scolaire, et, plus particulièrement, dans le programme du cours d’éducation physique. Le cycle, d'une durée de 6 semaines (6 x 50 minutes), a été dispensé à deux classes de rhétoriques (n=51). Les compétences des élèves ont été évaluées à l'aide d'un questionnaire avant et après le cycle, ainsi qu'une grille d'observation évaluant les habiletés gestuelles des élèves lors d'un protocole complet de réanimation de base d’une personne adulte avec un DEA. La moyenne des résultats des élèves au questionnaire est passée de 6,12 ± 3,25/20 (0,5-14) lors du pré-test à 17,32 ± 1,79 /20 (10,5-20) à l’issue du cycle (p=0,00). La moyenne au test pratique est de 17,16 ± 1,72/20 (13,66-20). La séquence de cours proposée a permis d’améliorer les connaissances théoriques des élèves, leurs habiletés gestuelles et leur confiance par rapport à leur capacité à porter secours à une victime d’un arrêt cardiaque, et s'inscrit clairement dans la philosophie du Pacte pour un Enseignement d’Excellence. [less ▲]Detailed reference viewed: 72 (7 ULiège) Corrigendum: Temporality of Features in Near-Death Experience NarrativesMartial, Charlotte ; Cassol, Helena ; Antonopoulos, Georgios et alin Frontiers in Human Neuroscience (2017)Detailed reference viewed: 27 (9 ULiège) Room temperature ferroelectricity in fluoroperovskite thin filmsMing Yang, Amit KC; García Castro, Andrès Camilo ; Borisov, Pavel et alin Scientific Reports (2017), 7The NaMnF3 fluoride-perovskite has been found, theoretically, to be ferroelectric under epitaxial strain becoming a promising alternative to conventional oxides for multiferroic applications. Nevertheless ... [more ▼]The NaMnF3 fluoride-perovskite has been found, theoretically, to be ferroelectric under epitaxial strain becoming a promising alternative to conventional oxides for multiferroic applications. Nevertheless, this fluoroperovskite has not been experimentally verified to be ferroelectric so far. Here we report signatures of room temperature ferroelectricity observed in perovskite NaMnF3 thin films grown on SrTiO3. Using piezoresponse force microscopy, we studied the evolution of ferroelectric polarization in response to external and built-in electric fields. Density functional theory calculations were also performed to help understand the strong competition between ferroelectric and paraelectric phases as well as the profound influences of strain. These results, together with the magnetic order previously reported in the same material, pave the way to future multiferroic and magnetoelectric investigations in fluoroperovskites. [less ▲]Detailed reference viewed: 13 (6 ULiège) Can electoral inequalities be legally justified?Bouhon, Frédéric in European Review of Public Law (2017), 2016(Automn), 839-879In light of the principle of equality, German, Belgian and British election law contain some legal rules that tend to distribute the faculty to influence the composition of the elected assemblies equally ... [more ▼]In light of the principle of equality, German, Belgian and British election law contain some legal rules that tend to distribute the faculty to influence the composition of the elected assemblies equally among the governed people, and others that tend to distribute it unequally. The inequality caused by the latter group may be to some extent legally justified by concerns for the general interest, but also provides rulers with means that help them to remain in power, which is hardly justifiable from a legal perspective. In these legal systems, parties are expected to gain a significant portion of the people’s support: not only should the parliament (as a whole) and its members (as individuals) represent the governed people, but the parties themselves are expected to be sufficiently representative of the people in order to access the legislative assemblies. Notably, this thesis draws examples from the case law of the European Court of Human Rights, from which relevant decisions are mentioned here. [less ▲]Detailed reference viewed: 21 (4 ULiège) Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritisSanchez, Christelle ; Bay-Jensen, Anne-Christine; Pap, Thomas et alin Osteoarthritis and Cartilage (2017), 25Detailed reference viewed: 40 (9 ULiège) Combining semi-automated image analysis techniques with machine learning algorithms to accelerate large scale genetic studiesAtkinson, Jonathan; Lobet, Guillaume; Noll, Manuel et alin GigaScience (2017)Background: Genetic analyses of plant root systems require large datasets of extracted architectural traits. To quantify such traits from images of root systems, researchers often have to choose between ... [more ▼]Background: Genetic analyses of plant root systems require large datasets of extracted architectural traits. To quantify such traits from images of root systems, researchers often have to choose between automated tools (that are prone to error and extract only a limited number of architectural traits) or semi-automated ones (that are highly time consuming). Findings: We trained a Random Forest algorithm to infer architectural traits from automatically extracted image descriptors. The training was performed on a subset of the dataset, then applied to its entirety. This strategy allowed us to (i) decrease the image analysis time by 73% and (ii) extract meaningful architectural traits based on image descriptors. We also show that these traits are sufficient to identify Quantitative Trait Loci that had previously been discovered using a semi-automated method. Conclusions: We have shown that combining semi-automated image analysis with machine learning algorithms has the power to increase the throughput of large scale root studies. We expect that such an approach will enable the quantification of more complex root systems for genetic studies. We also believe that our approach could be extended to other areas of plant phenotyping. [less ▲]Detailed reference viewed: 33 (5 ULiège) Energy Dissipation Within the Wave Run-Up at Stepped RevetmentsKerpen, Nils B.; Bung, Daniel B.; Valero Huerta, Daniel et alin Journal of Ocean University of China (2017), 16(4), 649-654To understand the processes and energy dissipation performance caused by turbulence during the wave run-up over a stepped revetment, hydraulic model tests with steady flow conditions are conducted and ... [more ▼]To understand the processes and energy dissipation performance caused by turbulence during the wave run-up over a stepped revetment, hydraulic model tests with steady flow conditions are conducted and correlated with unsteady flow conditions of the wave run-up within a short time frame. Under irregular waves, the run-up reduction over a stepped revetment is dependent on the Iribarren number and decreases for decreasing Iribarren numbers. Velocity gradients are found to be similar in a steady and unsteady flow regime near the pseudo-bottom. [less ▲]Detailed reference viewed: 53 (2 ULiège) Contemporary groups in the genetic evaluation of Nellore cattle using Bayesian inferenceAlves da Silva, Delvan; Fonseca e Silva, Fabyano; Torres Ventura, Henrique et alin Pesquisa Agropecuária Brasileira (2017), 52(8), 643-651The objective of this work was to evaluate the criteria for the formation of contemporary groups (CGs) in the genetic evaluation of body weight at weaning in Nellore cattle. A total of 713,474 records ... [more ▼]The objective of this work was to evaluate the criteria for the formation of contemporary groups (CGs) in the genetic evaluation of body weight at weaning in Nellore cattle. A total of 713,474 records from 3,066 herds located in Midwestern and Northern Brazil were used. Data were obtained from the genealogical registry of zebu breeds of the Brazilian association of zebu breeders. Data structures were defined based on the number of standard deviations (SDs) for outlier removal (±2.0, ±2.5, ±3.0, and ±3.5) and on the minimal number of animals per CG (3, 7, and 15). Genetic evaluation was performed with an animal model using Bayesian inference. Data structures with ±3.5 SDs and CG with at least 15 animals presented the highest additive genetic variance (82.65±2.93), and those with ±2.0 SDs and CG with at least 3 animals showed the lowest one (60.23±1.96). The proper formation of CGs results in better-quality data archives, allowing to obtain more trustable estimates for the genetic parameters. Better selection responses are obtained when the following criteria are adopted for the removal of outliers: 2.5, 3.0, and 3.5 standard deviations and a minimum of 15 animals per contemporary group. [less ▲]Detailed reference viewed: 12 (4 ULiège) La place des savoirs grammaticaux et lexicaux dans les référentiels de compétences (1999-2016) et dans certains manuels de langues modernesSimons, Germain ; Delbrassine, Daniel ; Van Hoof, Florence et alin Didactiques en pratique (2017), 3Cet article propose d'abord une lecture critique des référentiels de langues modernes qui ont été en vigueur en Communauté française de Belgique entre 1999 et 2016. Y sont principalement analysés les ... [more ▼]Cet article propose d'abord une lecture critique des référentiels de langues modernes qui ont été en vigueur en Communauté française de Belgique entre 1999 et 2016. Y sont principalement analysés les référentiels "Socles de compétences en langues modernes" et "Compétences terminales et savoirs requis en langues modernes". La deuxième partie de l'article porte sur l'analyse partielle de deux manuels, le "Nieuwe Tandem 2" et le "New Headway". Une des thèses des auteurs de l'article est que ces référentiels de compétences et ces supports didactiques peuvent accroître l'hétérogénéité des niveaux de maîtrise en langue et générer des inégalités dans l'apprentissage. L'article se termine en évoquant différentes pistes qui peuvent contribuer à limiter les risques identifiés. [less ▲]Detailed reference viewed: 43 (3 ULiège) Similarity of the Jovian satellite footprints: spots multiplicity and dynamicsBonfond, Bertrand ; Grodent, Denis ; Badman, S. V. et alin Icarus (2017), 292(2017), 208217In the magnetospheres of Jupiter and Saturn, the intense interaction of the satellites Io, Europa, Ganymede and Enceladus with their surrounding plasma environment leaves a signature in the aurora of the ... [more ▼]In the magnetospheres of Jupiter and Saturn, the intense interaction of the satellites Io, Europa, Ganymede and Enceladus with their surrounding plasma environment leaves a signature in the aurora of the planet. Called satellite footprints, these auroral features appear either as a single spot (Europa and Enceladus) or as multiple spots (Io and Ganymede). Moreover, they can be followed by extended trailing tails in the case of Io and Europa, while no tail has been reported for Ganymede and Enceladus, yet. Here we show that all Jovian footprints can be made of several spots. Furthermore, the footprints all experience brightness variations on timescale of 2-3 minutes. We also demonstrate that the satellite location relative to the plasma sheet is not the only driver for the footprint brightness, but that the plasma environment and the magnetic field strength also play a role. These new findings demonstrate that the Europa and Ganymede footprints are very similar to the Io footprint. As a consequence, the processes expected to take place at Io, such as the bi-directional electron acceleration by Alfvén waves or the partial reflection of these waves on plasma density gradients, can most likely be extended to the other footprints, suggesting that they are indeed universal processes. [less ▲]Detailed reference viewed: 69 (20 ULiège) Right-sided pulmonary venous return to the inferior vena cava: an exceptional malformation.Ellouze, Nesrine; FARHAT, Nesrine ; Desprechins, Brigitte et alin Acta Cardiologica (2017), 72(4), 489-490Detailed reference viewed: 30 (5 ULiège) Le flâneur et l'ethnographe. Sur le savoir des PhysiologiesStienon, Valérie in La Licorne (2017)Les Physiologies parues dans la première moitié du XIXe siècle dans la presse satirique illustrée et les collections des éditeurs de pittoresques livrent un certain savoir sur la société parisienne de la ... [more ▼]Les Physiologies parues dans la première moitié du XIXe siècle dans la presse satirique illustrée et les collections des éditeurs de pittoresques livrent un certain savoir sur la société parisienne de la Monarchie de Juillet. Elles le font en situant les contemporains dans leur biotope métropolitain et en pratiquant des formes de microsociologie par consignation des us et coutumes saisis à travers le prisme de l’observation quotidienne in situ. De ce point de vue, ces textes semblent proches de documents d’ethnographie critique, si on conçoit l’ethnographie comme la discipline qui s’occupe de la collecte sur le terrain de données anthropologiques et sociales. Ce geste ethnographique a pu être préparé par la rencontre du regard du clinicien sur le social et du réflexe classificateur du naturaliste auxquels s’ajoutent des données factuelles historiques : l’anthropologie française se développe à Paris dès 1799, suite à la découverte de l’enfant sauvage de l’Aveyron, avec la Société des observateurs de l’homme. Si celle-ci est dissoute très tôt, en 1804, d’autres groupements prennent le relais et, en 1839, la Société ethnologique est créée à Paris. Revenant sur le contexte qui prépare la naissance des disciplines ethnologique et sociologique, cette étude propose de croiser les scénographies énonciatives de l’ethnographe mises en œuvre dans les Physiologies à une autre figure du savoir en déambulation qu’elles thématisent abondamment, celle du flâneur, pour déterminer leurs généalogies littéraires et leurs apports respectifs au savoir (pré)sociologique manifesté par ces textes dans leur poétique d’écriture situable entre presse engagée, littérature et sciences du vivant. [less ▲]Detailed reference viewed: 41 (3 ULiège) Opinion Statement ECJ-TF 2/2017 on the ECJ Decision of 21 December 2016 in World Duty Free Group and Others (Joined Cases C-20/15 P and C-21/15 P), Concerning the Requirements of Selective Aid in the Sense of Article 107 of the TFEUCFE ECJ task Force; Richelle, Isabelle in European Taxation (2017), (2017), 354-357This CFE Opinion Statement, submitted to the European Institutions on 29 June 2017, discusses World Duty Free Group (formerly Autogrill España); Banco Santander and Santusa Holding (Joined Cases C-20/15 P ... [more ▼]This CFE Opinion Statement, submitted to the European Institutions on 29 June 2017, discusses World Duty Free Group (formerly Autogrill España); Banco Santander and Santusa Holding (Joined Cases C-20/15 P and C-21/15 P), wherein the ECJ held that that an aid can be regarded as selective if the national tax measure deviates from the reference framework: it is not necessary to show that the national tax measure actually favours a specific group of undertakings or the production of specific goods. [less ▲]Detailed reference viewed: 21 (0 ULiège) Confraternitas dolorum B.V.M. Officium de doloribus B.V.M., [Anvers : Govaert Bac, 1493-1494], 4° (Liège, Bibliothèque Alpha, XV C 149)Adam, Renaud in Arm@rium Universitatis Leodiensis : la Bibliothèque Numérique du Moyen Âge et de la Première Modernité de l’Université de Liège (2017)Detailed reference viewed: 15 (3 ULiège) Effect of Enzymatic Beech Fagus Sylvatica Wood Hydrolysate on Chlorella Biomass, Fatty Acid and Pigment ProductionMiazek, Krystian ; Remacle, Claire ; Richel, Aurore et alin Applied Sciences (2017)Detailed reference viewed: 29 (5 ULiège) RADIONUCLIDE IMAGING OF INFECTIVE ENDOCARDITIS: state of art and future perspectiveMARCHETTA, Stella ; WITHOFS, Nadia ; ERBA, Paola Anna et alin Current Cardiovascular Imaging Reports (2017), 10(27), Detailed reference viewed: 29 (2 ULiège) Responders to platelet-rich plasma (PRP) in osteoarthritis: A technical analysisMILANTS, Christophe ; Bruyère, Olivier ; Kaux, Jean-François in BioMed Research International (2017)Purpose. To evaluate the similarities and differences between the variety of platelet-rich plasma (PRP) formulations, preparation, and uses to try to determine the best responses for the treatment of knee ... [more ▼]Purpose. To evaluate the similarities and differences between the variety of platelet-rich plasma (PRP) formulations, preparation, and uses to try to determine the best responses for the treatment of knee osteoarthritis. Materials and Methods. A comparison of the outcomes of randomized controlled trials (RCTs) included in the 3 most recent and high-quality meta-analyses to classify the different studies in 2 groups (bad responders group (BRG) and very good responders group (VGRG)). Results and Discussion. From the 19 RCTs analyzed, 7 trials were included in the VGRG and 4 in the BRG. In VGRG, 1 or 2 injections were performed in 4/7 trials, time between injections was 2 to 3 weeks in 4/5 studies with many injections, volume injected varied from 2.5 to 8 mL, and single spinning technique was used in 5/7 studies. PRP classification was Mishra 4B and PAWP2B𝛽 in 5/7 studies. The use of PRP with leukocytes is only found in the BRG. Conclusion. There is a lack of standardization in PRP preparation technique for knee osteoarthritis. However it appears that the use of a single spinning technique, a platelet concentration lower than 5 times the baseline, and avoidance of leukocytes should be preferred. [less ▲]Detailed reference viewed: 59 (17 ULiège) Compte rendu des "Extras du Cifen" : année académique 2016-2017Guillaume, Jean-François ; Van Hoof, Florence ; Mouton, Alexandre et alin Didactiques en Pratique (2017), 3Ce compte rendu fait état de quatre activités organisées dans le cadre des "Extras du Cifen" lors de l'année académique 2016-17 : la conférence de Liana PINIAU sur la dyslexie (30/11/2016), la conférence ... [more ▼]Ce compte rendu fait état de quatre activités organisées dans le cadre des "Extras du Cifen" lors de l'année académique 2016-17 : la conférence de Liana PINIAU sur la dyslexie (30/11/2016), la conférence d'Elisabeth BAUTIER sur le langage (9/3/2017), la conférence de Loïc GISCHER sur la prévention du harcèlement (29/03/2017), et l'atelier organisé par Alexandre Mouton sur les premiers secours (3/5/2017). [less ▲]Detailed reference viewed: 39 (8 ULiège) EYK1 encoding erythrulose kinase as a catabolic selectable marker for genome editing in the non-conventional yeast Yarrowia lipolyticaVandermies, Marie ; Denies, Olivia ; Nicaud, Jean-Marc et alin Journal of Microbiological Methods (2017), 139We report here on EYK1, encoding erythrulose kinase, as an eﬃcient catabolic selectable marker for genome editing in Y. lipolytica. Compared to auxotrophic markers, EYK1 increases the growth rate of ... [more ▼]We report here on EYK1, encoding erythrulose kinase, as an eﬃcient catabolic selectable marker for genome editing in Y. lipolytica. Compared to auxotrophic markers, EYK1 increases the growth rate of transformants and allows improved eﬃciency of transformation. The utility of the marker EYK1 in a replicative vector was also demonstrated. [less ▲]Detailed reference viewed: 19 (2 ULiège) Chemical abundances of fast-rotating massive stars. II. Interpretation and comparison with evolutionary modelsCazorla, Constantin ; Nazé, Yaël ; Morel, Thierry et alin Astronomy and Astrophysics (2017), 604(A123), Aims: Past observations of fast-rotating massive stars exhibiting normal nitrogen abundances at their surface have raised questions about the rotational mixing paradigm. We revisit this question thanks to ... [more ▼]Aims: Past observations of fast-rotating massive stars exhibiting normal nitrogen abundances at their surface have raised questions about the rotational mixing paradigm. We revisit this question thanks to a spectroscopic analysis of a sample of bright fast-rotating OB stars, with the goal of quantifying the efficiency of rotational mixing at high rotation rates. Methods: Our sample consists of 40 fast rotators on the main sequence, with spectral types comprised between B0.5 and O4. We compare the abundances of some key element indicators of mixing (He, CNO) with the predictions of evolutionary models for single objects and for stars in interacting binary systems. Results: The properties of half of the sample stars can be reproduced by single evolutionary models, even in the case of probable or confirmed binaries that can therefore be true single stars in a pre-interaction configuration. The main problem for the rest of the sample is a mismatch for the [N/O] abundance ratio (we confirm the existence of fast rotators with a lack of nitrogen enrichment) and/or a high helium abundance that cannot be accounted for by models. Modifying the diffusion coefficient implemented in single- star models does not solve the problem as it cannot simultaneously reproduce the helium abundances and [N/O] abundance ratios of our targets. Since part of them actually are binaries, we also compared their chemical properties with predictions for post-mass transfer systems. We found that these models can explain the abundances measured for a majority of our targets, including some of the most helium-enriched, but fail to reproduce them in other cases. Our study thus reveals that some physical ingredients are still missing in current models. [less ▲]Detailed reference viewed: 26 (2 ULiège) Les experts belges auprès de la Cour Permanente de Justice Internationale (1921-1930). Indicateurs de la position de la Belgique dans la hiérarchie internationale ?Genin, Vincent in Cahiers SIRICE (2017), 2017/1(18), 61-76Detailed reference viewed: 11 (1 ULiège) Microbiological zoonotic emerging risks, transmitted between livestock animals and humans (2007-2015)Filippitzi, ME; Goumperis, T; Robinson, T et alin Transboundary and Emerging Diseases (2017), 64(4), 1059-1070Detailed reference viewed: 43 (7 ULiège) Administration of mesenchymal stromal cells before renal ischemia/reperfusion attenuates kidney injury and may modulate renal lipid metabolism in rats.ERPICUM, Pauline ; Rowart, Pascal ; POMA, Laurence et alin Scientific Reports (2017), 7(1), 8687Mesenchymal stromal cells (MSC) have been demonstrated to attenuate renal ischemia/reperfusion (I/R) damage in rodent models. The mechanisms of such nephro-protection remain largely unknown. Furthermore ... [more ▼]Mesenchymal stromal cells (MSC) have been demonstrated to attenuate renal ischemia/reperfusion (I/R) damage in rodent models. The mechanisms of such nephro-protection remain largely unknown. Furthermore, the optimal timing of MSC administration has been poorly investigated. Here, we compare the impact of MSC injection 7 days before (MSCD - 7) versus 1 day after (MSCD + 1) renal I/R in rats. Control groups received equivalent volumes of saline at similar time-points (SD - 7 and SD + 1). Right nephrectomy was performed, and left renal ischemia lasted 45 min. After 48-hour reperfusion, we observed significantly improved renal function parameters, reduced apoptotic index and neutrophil/macrophage infiltration in kidney parenchyma, and lower expression of tubular damage markers and pro-inflammatory cytokines in MSCD - 7 in comparison to MSCD + 1 and saline control groups. Next, comparative high-throughput RNA sequencing of MSCD - 7 vs. SD - 7 non-ischemic right kidneys highlighted significant down-regulation of fatty acid biosynthesis and up-regulation of PPAR-alpha pathway. Such a preferential regulation towards lipid catabolism was associated with decreased levels of lipid peroxidation products, i.e. malondialdehyde and 4-hydroxy-2-nonenal, in MSCD - 7 versus SD - 7 ischemic kidneys. Our findings suggest that MSC pretreatment may exert protective effects against renal I/R by modulating lipid metabolism in rats. [less ▲]Detailed reference viewed: 26 (11 ULiège) Organometallic-mediated alternating radical copolymerization of tert-butyl-2- trifluoromethacrylate with vinyl acetate and synthesis of block copolymers thereofBanerjee, Sanjib; Ladmiral, Vincent; Debuigne, Antoine et alin Macromolecular Rapid Communications (2017), 38(15), 1700203Organometallic-mediated radical polymerization (OMRP) has given access to well-defined poly(vinyl acetate-alt-tert-butyl-2-trifluoromethacrylate)-b-poly(vinyl acetate) and poly (VAc- alt-MAF-TBE ... [more ▼]Organometallic-mediated radical polymerization (OMRP) has given access to well-defined poly(vinyl acetate-alt-tert-butyl-2-trifluoromethacrylate)-b-poly(vinyl acetate) and poly (VAc- alt-MAF-TBE) copolymers composed of two electronically distinct monomers: vinyl acetate (VAc, donor, D) and tert-butyl-2-trifluoromethacrylate (MAF-TBE, acceptor, A), with low dispersity (≤1.24) and molar masses up to 57 000 g mol−1. These copolymers have a precise 1:1 alternating structure over a wide range of comonomer feed compositions. The reactivity ratios are determined as rVAc = 0.01 ± 0.01 and rMAF-TBE = 0 at 40 °C. Remarkably, from a feed containing >50% molar VAc content, poly(VAc-alt-MAF-TBE)-b- PVAc block copolymers are produced via a one- pot synthesis. Such diblock copolymers exhibit two glass transition temperatures attributed to the alternating and homopolymer sequences. The OMRP of this fluorine-containing alter- nating monomer system may provide access to a wide range of new polymer materials. [less ▲]Detailed reference viewed: 52 (6 ULiège) The Forgotten History of Repetitive Audio TechnologiesLevaux, Christophe in Organised Sound (2017), 22(2), 187-194Detailed reference viewed: 30 (6 ULiège) Regiospecific radiolabelling of Nanofitin on Ni Magnetic Beads with [18F]FBEM and in vivo PET studiesDammicco, Sylvestre ; Goux, Marine; Lemaire, Christian et alin Nuclear Medicine & Biology (2017)Introduction: Nanofitins are low molecular weight, single chain and cysteine-free protein scaffolds able to selectively bind a defined biological target. They derive from Sac7d bacterial protein family ... [more ▼]Introduction: Nanofitins are low molecular weight, single chain and cysteine-free protein scaffolds able to selectively bind a defined biological target. They derive from Sac7d bacterial protein family and are highly stable over a wide range of pH (0-13) and temperature (Tm ~80°C). Their extreme stability, low cost of production and high tolerability for chemical coupling make Nanofitins a very interesting alternative to antibodies and their fragments. Here, a hexahistidine tagged model Nanofitin (H4) directed against hen egg white lysozyme was radiolabelled and injected in mice to provide a baseline biodistribution and pharmacokinetic profiles to support future Nanofitin development programs. Method: A single cysteine residue has been genetically inserted in a model Nanofitin and its regioselective radiolabelling has been performed with 4-[18F]fluorobenzamido-N-ethylamino-maleimide ([18F]FBEM). The synthesis of [18F]FBEM has been completely implemented on a radiosynthesis unit (FastLab) including HPLC purification and formulation. Coupling with the [18F]FBEM has been achieved on a solid support (Ni magnetic beads) allowing rapid purification at room temperature without organic solvent. PET-MRI studies on C57BL/6 mice were conducted after injection of [18F]FBEM-Cys-H4 in order to access the biodistribution of this Nanofitin model. Results: Radiochemical yield (decay corrected) of 54±7% (n=4) was obtained after optimization for coupling the [18F]FBEM to Nanofitin. Pharmacokinetics results of [18F]FBEM-Cys-H4 revealed a fast clearance through the liver and the kidneys. Conclusion: An efficient new method on Ni magnetic beads was developed to radiolabelled his-tagged biomolecules with [18F]FBEM. This procedure was applied on a Nanofitin model Cys-H4 and biodistribution kinetic studies were achieved to evaluate the potential use of Nanofitin for diagnostic imaging. Fast clearance indicates that Nanofitins represent very interesting tools for diagnostic imaging. [less ▲]Detailed reference viewed: 51 (30 ULiège) Identification of putative QTLs for seedling stage phosphorus starvation response in finger millet (Eleusine coracana L. Gaertn.) by association mapping and cross species synteny analysisRamakrishnan, M.; Stanislaus, Antony Ceasar ; Vinod et alin PLoS ONE (2017), 12(8), 1-27A germplasm assembly of 128 finger millet genotypes from 18 countries was evaluated for seedling-stage phosphorus (P) responses by growing them in P sufficient (Psuf) and P deficient (Pdef) treatments ... [more ▼]A germplasm assembly of 128 finger millet genotypes from 18 countries was evaluated for seedling-stage phosphorus (P) responses by growing them in P sufficient (Psuf) and P deficient (Pdef) treatments. Majority of the genotypes showed adaptive responses to low P condition. Based on phenotype behaviour using the best linear unbiased predictors for each trait, genotypes were classified into, P responsive, low P tolerant and P non-responsive types. Based on the overall phenotype performance under Pdef, 10 genotypes were identified as low P tolerants. The low P tolerant genotypes were characterised by increased shoot and root length and increased root hair induction with longer root hairs under Pdef, than under Psuf. Association mapping of P response traits using mixed linear models revealed four quantitative trait loci (QTLs). Two QTLs (qLRDW.1 and qLRDW.2) for low P response affecting root dry weight explained over 10% phenotypic variation. In silico synteny analysis across grass genomes for these QTLs identified putative candidate genes such as Ser-Thr kinase and transcription factors such as WRKY and basic helix-loop-helix (bHLH). The QTLs for response under Psuf were mapped for traits such as shoot dry weight (qHSDW.1) and root length (qHRL.1). Putative associations of these QTLs over the syntenous regions on the grass genomes revealed proximity to cytochrome P450, phosphate transporter and pectin methylesterase inhibitor (PMEI) genes. This is the first report of the extent of phenotypic variability for P response in finger millet genotypes during seedling-stage, along with the QTLs and putative candidate genes associated with P starvation tolerance [less ▲]Detailed reference viewed: 6 (0 ULiège) A fast and simple method for simultaneous measurements of 25(OH)D, 24,25(OH)2D and the Vitamin D Metabolite Ratio (VMR) in serum samples by LC-MS/MSFabregat Cabello, Neus ; Farre Segura, Jordi ; Huyghebaert, Loreen et alin Clinica Chimica Acta (2017)BACKGROUND: Rapid, easy and reliable measurement of the major vitamin D metabolites is required in order to fulfill the needs of a clinical routine laboratory. To overcome these challenges, we have ... [more ▼]BACKGROUND: Rapid, easy and reliable measurement of the major vitamin D metabolites is required in order to fulfill the needs of a clinical routine laboratory. To overcome these challenges, we have developed and validated a LC-MS/MS method for the quantification of 25-hydroxyvitamin D2 and D3, epi-25-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3. METHODS: Sample preparation was based on precipitation and centrifugation of 100 µL of patient serum, followed by injection into the LC-MS/MS system. Samples from Vitamin D Standardization Program (n=80) and patient samples (n=281) have been compared with a reference LC-MS/MS method. For the analytical validation NIST and Labquality quality control materials were used. RESULTS: Mean intra-assay and inter-assay imprecision were less than 6.0 and 6.4% and mean recoveries were within 95-104%. LOQ’s were 0.5 µg/L for 24,25(OH)2D3, 1.1 µg/L for 25(OH)D3 and epi-25(OH)D3 and 1.7 µg/L for 25(OH)D2. A 3% bias obtained between the proposed and the reference method satisfies Vitamin D Standardization Program recommendations. CONCLUSIONS: We present a rapid, easy, reliable and cost-effective method completely adequate for routine testing, which permits the measurement of the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D, Vitamin D Metabolite Ratio (VMR), in serum samples. [less ▲]Detailed reference viewed: 39 (16 ULiège) La difficile jointure des directives EU anti-BEPS et des traités fiscauxDocclo, Caroline in Fiscologue International = Fiscoloog internationaal (2017)Detailed reference viewed: 46 (7 ULiège) Cation Distribution Dependent Magnetic Properties in CoCr 2-x Fe x O 4 (x= 0.1 to 0.5): EXAFS, Mӧssbauer and Magnetic MeasurementsKumar, Durgesh; Banerjee, Alok; Mahmoud, Abdelfattah et alin Dalton Transactions (2017), 46In this report, we have examined the evolution of the structure and rich magnetic transitions such as a paramagnetic to ferrimagnetic phase transition at the Curie temperature (TC), spiral ordering ... [more ▼]In this report, we have examined the evolution of the structure and rich magnetic transitions such as a paramagnetic to ferrimagnetic phase transition at the Curie temperature (TC), spiral ordering temperature (TS) and lock-in temperature (TL) observed in the CoCr2O4 spinel multiferroic after substituting Fe. The crystal structure, microstructure and cation distribution among the tetrahedral (A) and octahedral (B) sites in the spinel lattice are characterised by X-ray diffraction, transmission electron microscopy, Extended X-ray Absorption Fine Structure (EXAFS) and Mössbauer spectroscopy. Due to the same radial distances of the first coordination shell in both tetrahedral and octahedral environments observed in EXAFS spectra, the position of the second coordination shell specifies the preference of more Fe ions towards the A site at x = 0.1. At x = 0.5, more Fe ions favour the B site. The cation distribution quantitatively obtained from the Mössbauer spectral analysis shows that while 60% of Fe ions occupy the A site in x = 0.1, 40% occupy it in x = 0.5. Surprisingly at x = 0.3, Fe ions are distributed equally among the A and B sites. dc magnetization reveals an increase in TC from 102 K to 200 K and in TS from 26 to 40 K with an increase in Fe concentration, indicating an enhancement in A–B exchange interaction at the expense of B–B. No report has until now demonstrated such an enhancement in TS either in pure or in doped CoCr2O4. Furthermore, frequency-dependent ac susceptibility (χ) data fitted with different phenomenological models such as the Néel–Arrhenius, Vogel–Fulcher and power law confirm a spin-glass and/or cluster-glass behaviour in nanoparticles of CoCr2−xFexO4. [less ▲]Detailed reference viewed: 13 (4 ULiège) Le maraîchage périurbain à Libreville et Owendo (Gabon) : pratiques culturales et durabilitéBayendi-Loudit, Sandrine ; Ndoutoume Ndong, Auguste; Francis, Frédéric in Cahiers Agricultures (2017)In Gabon, peri-urban gardening is an opportunity to provide vegetables to the main cities, such as Libreville and Owendo. Following a survey conducted in three market gardening areas, an inventory was ... [more ▼]In Gabon, peri-urban gardening is an opportunity to provide vegetables to the main cities, such as Libreville and Owendo. Following a survey conducted in three market gardening areas, an inventory was conducted on the socio-economic characteristics, the diversity of crops, and pesticide uses. The cropped areas range from 0.08 ha to 0.4 ha per farmer, according to the site. National operators represent 51%, while people from Burkina Faso manage 40% of vegetable production. The most cultivated species throughout the year are amaranth (Amaranthus hybridus L.), lettuce (Lactuca sativa L.), Guinea sorrel (Hibiscus sabdariffa L.) and black nightshade (Solanum nigrum L.). The most important pests are Aphididae and some beetles. The most commonly used plant protection products are insecticides, mainly conventional neurotoxic. Best crop monitoring, pest control including pesticide application reduction, and the possibility to offer microcredit systems to small producers would help increasing peri-urban healthy vegetable production and increase local food autonomy [less ▲]Detailed reference viewed: 40 (10 ULiège) Synthesis and complexation of superbulky imidazolium-2-dithiocarboxylate ligandsBeltran Alvarez, Tomás Francisco ; Zaragoza, Guillermo; Delaude, Lionel in Dalton Transactions (Cambridge, England : 2003) (2017), 46(28), 9036-9048The superbulky N-heterocyclic carbenes (NHCs) 2,6-bis(diphenylmethyl)-4-methylimidazol-2-ylidene (IDip*Me) and its 4-methoxy analogue (IDip*OMe) reacted instantaneously with carbon disulfide to afford the ... [more ▼]The superbulky N-heterocyclic carbenes (NHCs) 2,6-bis(diphenylmethyl)-4-methylimidazol-2-ylidene (IDip*Me) and its 4-methoxy analogue (IDip*OMe) reacted instantaneously with carbon disulfide to afford the corresponding imidazolium-2-dithiocarboxylate zwitterions in high yields. These new dithiolate ligands were fully characterized and their coordination chemistry toward common Re(i) and Ru(ii) metal sources was thoroughly investigated. Neutral [ReBr(CO)3(S2C[middle dot]NHC)] chelates featured three facially-arranged carbonyl groups on a distorted octahedron, whereas cationic [RuCl(p-cymene)(S2C[middle dot]NHC)]PF6 complexes displayed a piano-stool geometry. The molecular structures of the six new compounds revealed that the NHC[middle dot]CS2 inner salts were highly flexible. Indeed, the torsion angle between their anionic and cationic moieties varied between ca. 63[degree] in the free ligands and 3[degree] in the ruthenium complexes. Concomitantly, the S-C-S bite angle underwent a contraction from 131[degree] to 110-113[degree] upon chelation. Computation of the %VBur parameter showed that the dithiocarboxylate unit of the NHC[middle dot]CS2 betaines chiefly determined the steric requirements of the imidazolium moieties, irrespective of the metal center involved in the complexation. The replacement of the p-methyl substituents of IDip*Me with p-methoxy groups in IDip*OMe did not significantly affect the ligand bulkiness. The more electron-donating methoxy group led, however, to small changes in various IR wavenumbers used to probe the electron donor properties of the carbene moiety. [less ▲]Detailed reference viewed: 15 (3 ULiège) Spray-drying as a tool to disperse conductive carbon inside Na2FePO4F particles by addition of carbon black or carbon nanotubes to the precursor solutionMahmoud, Abdelfattah ; Caes, Sebastien; Brisbois, Magali et alin Journal of Solid State Electrochemistry (2017)In this work, Na2FePO4F-carbon composite powders were prepared by spray-drying a solution of inorganic precursors with 10 and 20 wt% added carbon black (CB) or carbon nanotubes (CNTs). In order to compare ... [more ▼]In this work, Na2FePO4F-carbon composite powders were prepared by spray-drying a solution of inorganic precursors with 10 and 20 wt% added carbon black (CB) or carbon nanotubes (CNTs). In order to compare the effect of CB and CNTwhen added to the precursor solutions, the structural, electrochemical, and morphological properties of the synthesized Na2FePO4F-xCB and Na2FePO4F-xCNT samples were systematically investigated. In both cases, X-ray diffraction shows that calcination at 600 °C in argon leads to the formation of Na2FePO4F as the major inorganic phase. 57Fe Mössbauer spectroscopy was used as complementary technique to probe the oxidation states, local environment, and identify the composition of the iron-containing phases. The electrochemical performance is markedly better in the case of Na2FePO4F-CNT (20 wt%), with specific capacities of about 100 mAh/g (Na2FePO4F-CNT) at C/4 rate vs. 50 mAh/g for Na2FePO4F-CB (20 wt%). SEM characterization of Na2FePO4F-CB particles revealed different particle morphologies for the Na2FePO4F-CNT and Na2FePO4F-CB powders. The carbon-poor surface observed for Na2FePO4FCB could be due to a slow diffusion of carbon in the droplets during drying. On the contrary, Na2FePO4F-CNT shows a better CNT dispersion inside and at the surface of the NFPF particles that improves the electrochemical performance. [less ▲]Detailed reference viewed: 40 (14 ULiège) Occupational social and mental stimulation and cognitive decline with advancing ageGrotz, Catherine ; Meillon, Céline; Amieva, Hélène et alin Age and Ageing (2017)Detailed reference viewed: 37 (3 ULiège) Deep imaging search for planets forming in the TW Hya protoplanetary disk with the Keck/NIRC2 vortex coronagraphRuane, G.; Mawet, D.; Kastner, J. et alin Astronomical Journal (The) (2017), 154Distinct gap features in the nearest protoplanetary disk, TW Hya (distance of 59.5$\pm$0.9 pc), may be signposts of ongoing planet formation. We performed long-exposure thermal infrared coronagraphic ... [more ▼]Distinct gap features in the nearest protoplanetary disk, TW Hya (distance of 59.5$\pm$0.9 pc), may be signposts of ongoing planet formation. We performed long-exposure thermal infrared coronagraphic imaging observations to search for accreting planets especially within dust gaps previously detected in scattered light and submm-wave thermal emission. Three nights of observations with the Keck/NIRC2 vortex coronagraph in $L^\prime$ (3.4-4.1$\mu$m) did not reveal any statistically significant point sources. We thereby set strict upper limits on the masses of non-accreting planets. In the four most prominent disk gaps at 24, 41, 47, and 88 au, we obtain upper mass limits of 1.6-2.3, 1.1-1.6, 1.1-1.5, and 1.0-1.2 Jupiter masses ($M_J$) assuming an age range of 7-10 Myr for TW Hya. These limits correspond to the contrast at 95\% completeness (true positive fraction of 0.95) with a 1\% chance of a false positive within $1^{\prime\prime}$ of the star. We also approximate an upper limit on the product of planet mass and planetary accretion rate of $M_p\dot{M}\lesssim10^{-8} M_J^2/yr$ implying that any putative $\sim0.1 M_J$ planet, which could be responsible for opening the 24 au gap, is presently accreting at rates insufficient to build up a Jupiter mass within TW Hya's pre-main sequence lifetime. [less ▲]Detailed reference viewed: 24 (7 ULiège) Is supercritical fluid chromatography hyphenated to massspectrometry suitable for the quality control of vitamin D3 oilyformulations?Andri, Bertyl ; Dispas, Amandine ; Klinkenberg, Régis et alin Journal of Chromatography. A (2017), 1515Nowadays, many efforts are devoted to improve analytical methods regarding efficiency, analysis timeand greenness. In this context, Supercritical Fluid Chromatography (SFC) is often regarded as a ... [more ▼]Nowadays, many efforts are devoted to improve analytical methods regarding efficiency, analysis timeand greenness. In this context, Supercritical Fluid Chromatography (SFC) is often regarded as a goodalternative over Normal Phase Liquid Chromatography (NPLC). Indeed, modern SFC separations arefast, efficient with suitable quantitative performances. Moreover, the hyphenation of SFC to mass spec-trometry (MS) provides additional gains in specificity and sensitivity. The present work aims at thedetermination of vitamin D3 by SFC-MS for routine Quality Control (QC) of medicines specifically. Basedon the chromatographic parameters previously defined in SFC-UV by Design of Experiments (DoE) andDesign Space methodology, the method was adapted to work under isopycnic conditions ensuring a base-line separation of the compounds. Afterwards, the response provided by the MS detector was optimizedby means of DoE methodology associated to desirability functions. Using these optimal MS parameters,quantitative performances of the SFC-MS method were challenged by means of total error approachmethod validation. The resulting accuracy profile demonstrated the full validity of the SFC-MS method. It was indeed possible to meet the specification established by the European Medicines Agency (EMA) (i.e. 95.0 − 105.0% of the API content) for a dosing range corresponding to at least 70.0-130.0% of theAPI content. These results highlight the possibility to use SFC-MS for the QC of medicine and obviouslysupport the switch to greener analytical methods. [less ▲]Detailed reference viewed: 23 (6 ULiège) Mapping the dependency of crops on pollinators in BelgiumJacquemin, Floriane ; Violle, Cyrille; Rasmont, Pierre et alin One Ecosystem (2017)Detailed reference viewed: 35 (5 ULiège) Evaluating model simulations of 20th century sea-level rise. Part 1: Global mean sea-level changeSlangen, A.; Meyssignac, B.; Agosta, Cécile et alin Journal of Climate (2017)Sea-level change is one of the major consequences of climate change and is projected to affect coastal communities around the world. Here, we compare Global Mean Sea-Level (GMSL) change estimated by 12 ... [more ▼]Sea-level change is one of the major consequences of climate change and is projected to affect coastal communities around the world. Here, we compare Global Mean Sea-Level (GMSL) change estimated by 12 climate models from the 5th phase of the World Climate Research Programme’s Climate Model Intercomparison Project (CMIP5) to observational estimates for the period 1900-2015. We analyse observed and simulated individual contributions to GMSL change (thermal expansion, glacier mass change, ice sheet mass change, landwater storage change) and compare the summed simulated contributions to observed GMSL change over the period 1900-2007 using tide gauge reconstructions, and over the period 1993-2015 using satellite altimetry estimates. The model-simulated contributions allow us to explain 50 ± 30% (uncertainties 1.65σ unless indicated otherwise) of the mean observed change from 1901-1920 to 1988-2007. Based on attributable biases between observations and models, we propose to add a number of corrections, which result in an improved explanation of 75 ± 38% of the observed change. For the satellite era (1993-1997 to 2011-2015) we find an improved budget closure of 102 ± 33% (105 ± 35% when including the proposed bias corrections). Simulated decadal trends over the 20th century increase, both in the thermal expansion and the combined mass contributions (glaciers, ice sheets and landwater storage). The mass components explain the majority of sea-level rise over the 20th century, but the thermal expansion has increasingly contributed to sea-level rise, starting from 1910 onwards and in 2015 accounting for 46% of the total simulated sea-level change. [less ▲]Detailed reference viewed: 37 (4 ULiège) Shape and spin determination of Barbarian asteroidsDevogele, Maxime ; Tanga, P.; Bendjoya, P. et alin Astronomy and Astrophysics (2017)The so-called Barbarian asteroids share peculiar, but common polarimetric properties, probably related to both their shape and composition. They are named after (234) Barbara, the first on which such ... [more ▼]The so-called Barbarian asteroids share peculiar, but common polarimetric properties, probably related to both their shape and composition. They are named after (234) Barbara, the first on which such properties were identified. As has been suggested, large scale topographic features could play a role in the polarimetric response, if the shapes of Barbarians are particularly irregular and present a variety of scattering/incidence angles. This idea is supported by the shape of (234) Barbara, that appears to be deeply excavated by wide concave areas revealed by photometry and stellar occultations. Aims. With these motivations, we started an observation campaign to characterise the shape and rotation properties of Small Main- Belt Asteroid Spectroscopic Survey (SMASS) type L and Ld asteroids. As many of them show long rotation periods, we activated a worldwide network of observers to obtain a dense temporal coverage. Methods. We used light-curve inversion technique in order to determine the sidereal rotation periods of 15 asteroids and the con- vergence to a stable shape and pole coordinates for 8 of them. By using available data from occultations, we are able to scale some shapes to an absolute size. We also study the rotation periods of our sample looking for confirmation of the suspected abundance of asteroids with long rotation periods. Results. Our results show that the shape models of our sample do not seem to have peculiar properties with respect to asteroids with similar size, while an excess of slow rotators is most probably confirmed. [less ▲]Detailed reference viewed: 63 (6 ULiège) Self-assembly processes of superparamagnetic colloids in a quasi-two-dimensional systemRojas, Nicolas; Darras, Alexis ; Lumay, Geoffroy in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2017), 96(1), 012608Superparamagnetic colloids gather depending on the magnitude of the magnetic field applied, forming chains and ribbons in a quasi-two-dimensional chamber. The results presented in this work are in good ... [more ▼]Superparamagnetic colloids gather depending on the magnitude of the magnetic field applied, forming chains and ribbons in a quasi-two-dimensional chamber. The results presented in this work are in good agreement with recent experimental multistable data for the mean length of the aggregates in thermodynamic equilibrium. [less ▲]Detailed reference viewed: 39 (5 ULiège) Do Management and Executive Share the same Perception on the critical Issues Facing the Frontline Nursing Staff ?Nyssen, Anne-Sophie ; GILLET, Aline ; Sougné, Jacques et alin International Journal of Healthcare Management (2017)Changes in managerial practices increasingly distance managers from staff by promoting rotation. It could be thought that this distance changes the perception managers have of work constraints and ... [more ▼]Changes in managerial practices increasingly distance managers from staff by promoting rotation. It could be thought that this distance changes the perception managers have of work constraints and resources. This study attempts to tackle staff and leadership disparate views on the issues facing front-line nursing staff. We sent an online questionnaire on work constraints and good practices to nursing chiefs from Belgium hospitals and conducted focus groups with their ‘front-line’ nursing staff in order to compare perceptions. 40% of the chief nurses mentioned as a regular problems for their staff: production pressure, working time, doctors–nurses collaboration and managing new staff. Except for the ‘productive pressure’, these issues are rather considered by the staff as occasional problems. Front-line staffs evaluate infrastructure, heat, working positions as more common problems. However, statistical analyses showed one significant difference in perception: management of incidents/accidents. Health care organizations should promote participatory management tools both to diagnose work constraints and to elaborate action priorities in order to guarantee a shared understanding of decisions making between staff and supervisors. [less ▲]Detailed reference viewed: 30 (7 ULiège) Acromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) database.PETROSSIANS, Patrick ; Daly, Adrian ; Natchev, Emil et alin Endocrine-Related Cancer (2017)Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly ... [more ▼]Acromegaly is a rare disorder caused by chronic growth hormone (GH) hypersecretion. While diagnostic and therapeutic methods have advanced, little information exists on trends in acromegaly characteristics over time. The Liege Acromegaly Survey (LAS) database, a relational database, is designed to assess the profile of acromegaly patients at diagnosis and during long-term follow-up at multiple treatment centers. The study population consisted of 3173 acromegaly patients from ten countries; 54.5% were female. Males were significantly younger at diagnosis than females (43.5 vs. 46.4 years; p<0.001). The median delay from first symptoms to diagnosis was two years longer in females (p=0.015). Ages at diagnosis and first symptoms increased significantly over time (p<0.001). Tumors were larger in males than females (p<0.001); tumor size and invasion were inversely related to patient age (p<0.001). Random GH at diagnosis correlated with nadir GH levels during OGTT (p<0.001). GH was inversely related to age in both sexes (p<0.001). Diabetes mellitus was present in 27.5%, hypertension in 28.8%, sleep apnea syndrome in 25.5% and cardiac hypertrophy in 15.5%. Serious cardiovascular outcomes like stroke, heart failure and myocardial infarction were present in <5% at diagnosis. Erythrocyte levels were increased and correlated with IGF-1 values. Thyroid nodules were frequent (34.0%); 820 patients had colonoscopy at diagnosis and 13% had polyps. Osteoporosis was present at diagnosis in 12.3% and 0.6-4.4% had experienced a fracture. This study of >3100 patients is the largest international acromegaly database and shows clinically relevant trends in the characteristics of acromegaly at diagnosis. [less ▲]Detailed reference viewed: 48 (3 ULiège) Typical versus delayed speech onset influences verbal reporting of autistic interestsChiodo, Liliane ; Majerus, Steve ; Mottron, Laurentin Molecular Autism (2017)The distinction between autism and Asperger syndrome has been abandoned in the DSM-5. However, this clinical categorization largely overlaps with the presence or absence of a speech onset delay which is ... [more ▼]The distinction between autism and Asperger syndrome has been abandoned in the DSM-5. However, this clinical categorization largely overlaps with the presence or absence of a speech onset delay which is associated with clinical, cognitive, and neural differences. It is unknown whether these different speech development pathways and associated cognitive differences are involved in the heterogeneity of the restricted interests that characterize autistic adults. [less ▲]Detailed reference viewed: 50 (1 ULiège) Number of inadvertent RNA targets for morpholino knockdown in Danio rerio is largely underestimated: evidence from the study of Ser/Arg-rich splicing factors.Joris, Marine ; Schloesser, Marie ; Baurain, Denis et alin Nucleic Acids Research (2017), 45(16), 9547-9557Detailed reference viewed: 15 (0 ULiège) Natural patches in Posidonia oceanica meadows: the seasonal biogeochemical pore water characteristics of two edge typesAbadie, A; Borges, Alberto ; Champenois, Willy et alin Marine Biology (2017), 164:166Seagrass meadows can be assimilated to seascape matrixes encompassing a mosaic of natural and anthropogenic patches. Natural patches within the Mediterranean Posidonia oceanica meadows show a structural ... [more ▼]Seagrass meadows can be assimilated to seascape matrixes encompassing a mosaic of natural and anthropogenic patches. Natural patches within the Mediterranean Posidonia oceanica meadows show a structural particularity which consist in a duality of their edge types. One edge is eroded by bottom currents, while the adjacent meadow colonizes the bare sediments. This study aims to study the dynamics of these two edges through the investigation of the biogeochemistry (pH, total alkalinity, dissolved inorganic carbon, CO2, CH4, N2O, H2S, dissolved inorganic nitrogen, PO4 3−) within vegetated and unvegetated sediments. These observations are compared with the adjacent meadow to have a better understanding of the colonization processes. Our results reveal that the P. oceanica matrix shows differences from the vegetated edges of sand patches, especially with regard to nutrient availability, which is generally more important at the colonized edge (dissolved inorganic nitrogen up to 65.39 μM in June). A clear disparity also occurs between the eroded and colonized edge with both a seasonal and bathymetrical variation of leaf biomass with higher disparities at 10 m in June (colonized edge 1415 gDW m−2; eroded edge 1133 gDW m−2). Themost important contrasts during this study were assessed in June, suggesting that the warm period of the year is more suitable for sampling to highlight disparate characteristics in temperate seagrass meadows. These findings put into light the potential importance of biogeochemical processes in the dynamics of natural patch edges. We hypothesize that they may influence the structural dynamics of P. oceanica seascapes. [less ▲]Detailed reference viewed: 35 (8 ULiège) Host interleukin 6 production regulates inflammation but not tryptophan metabolism in the brain during murine GVHDBelle, Ludovic ; Zhou, Vivian; Stuhr, KL et alin JCI Insight (2017), 2(14), Graft-versus-host disease (GVHD) induces pathological damage in peripheral target organs leading to well-characterized, organ-specific clinical manifestations. Patients with GVHD, however, can also have ... [more ▼]Graft-versus-host disease (GVHD) induces pathological damage in peripheral target organs leading to well-characterized, organ-specific clinical manifestations. Patients with GVHD, however, can also have behavioral alterations that affect overall cognitive function, but the extent to which GVHD alters inflammatory and biochemical pathways in the brain remain poorly understood. In the current study, we employed complementary murine GVHD models to demonstrate that alloreactive donor T cells accumulate in the brain and affect a proinflammatory cytokine milieu that is associated with specific behavioral abnormalities. Host IL-6 was identified as a pivotal cytokine mediator, as was host indoleamine 2,3-dioxygenase (IDO-1), which was upregulated in GVHD in an IL-6-dependent manner in microglial cells and was accompanied by dysregulated tryptophan metabolism in the dorsal raphe nucleus and prefrontal cortex. Blockade of the IL-6 signaling pathway significantly reduced donor T cell accumulation, inflammatory cytokine gene expression, and host microglial cell expansion, but did not reverse GVHD-induced tryptophan metabolite dysregulation. Thus, these results indicate that inhibition of IL-6 signaling attenuates neuroinflammation, but does not reverse all of the metabolic abnormalities in the brain during GVHD, which may also have implications for the treatment of neurotoxicity occurring after other T cell-based immune therapies with IL-6-directed approaches. [less ▲]Detailed reference viewed: 12 (1 ULiège) A palaeoecological model for the late Mesoproterozoic–early Neoproterozoic Atar/El Mreïti Group, Taoudeni Basin, Mauritania, northwestern AfricaBeghin, Jérémie ; Guilbaud, Romain; Poulton, Simon W. et alin Precambrian Research (2017), 299Reconstructing the spatial distribution of early eukaryotes in palaeoenvironments through Proterozoic sedimentary basins provides important information about their palaeoecology and taphonomic conditions ... [more ▼]Reconstructing the spatial distribution of early eukaryotes in palaeoenvironments through Proterozoic sedimentary basins provides important information about their palaeoecology and taphonomic conditions. Here, we combine the geological context and a reconstruction of palaeoenvironmental redox conditions (using iron speciation) with quantitative analysis of microfossil assemblages (eukaryotes andincertae sedis), to provide the first palaeoecological model for the Atar/El Mreïti Group of the Taoudeni Basin. Our model suggests that in the late Mesoproterozoic–early Neoproterozoic, the availability of both molecular oxygen and nutrients controlled eukaryotic diversity, higher in oxic shallow marginal marine environments, while coccoidal colonies and benthic microbial mats dominated respectively in anoxic iron-rich and euxinic waters during marine highstands or away from shore where eukaryotes are lower or absent. [less ▲]Detailed reference viewed: 23 (2 ULiège) Fardeau des maladies chroniques en Afrique subsaharienne : plaidoyer pour une mise en place des soins palliatifs et d’accompagnement en fin de vie en République démocratique du CongoLofandjola Masumbuku, Jacques ; Kiswaya Sumaili, Ernest; Petermans, Jeanin Ethics, Medicine and Public Health (2017)Chronic diseases (TM), to date, a burden globally, putting patients in greater need prolonged medical support. CMs are long-term (over 6 months) chronic conditions that evolve and persist over time. They ... [more ▼]Chronic diseases (TM), to date, a burden globally, putting patients in greater need prolonged medical support. CMs are long-term (over 6 months) chronic conditions that evolve and persist over time. They require care for more than 6 months (cardiovascular, oncological diseases, chronic respiratory diseases, diabetes and HIV / AIDS), are responsible for 63% death. Relatively little reliable information about these diseases is available. Lists containing the major chronic diseases exist but they are scalable and do not always agree [less ▲]Detailed reference viewed: 29 (6 ULiège)