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See detailLe développement des cellules CAR-T et autre thérapie génique : tout n’est pas si simple
Dalle, Jean-Hugues; BAUDOUX, Etienne ULiege; Caillat-Zucman, Sophie et al

in Bulletin du Cancer (2020), 107(4), 408-409

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See detailThe Value of a Patient-Level Modeling Approach and Need for Better Reporting in Economic Evaluations of Osteoporosis
Hiligsmann, Mickael; Reginster, Jean-Yves ULiege; Silverman, Stuart

in Journal of Managed Care and Specialty Pharmacy (2020), 26(3), 334-335

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See detailSafe doubling of ventilator capacity: A last resort proposal for last resorts
Chase, J. G.; Chiew, Y. S.; Lambermont, Bernard ULiege et al

in Critical Care (2020), 24(1),

[No abstract available]

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See detailLetter to the Editor in response to “COVID-19: desperate times call for desperate measures
Chase, JG; Chiew, YS; LAMBERMONT, Bernard ULiege et al

in Critical Care (2020)

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See detailIslands of Awareness or Cortical Complexity?
Cecconi, Benedetta ULiege; LAUREYS, Steven ULiege; Annen, Jitka ULiege

in Trends in Neurosciences (2020)

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See detailReply to Kratz et al.
Frebourg, T.; Lagercrantz, S. B.; Oliveira, C. et al

in European Journal of Human Genetics (2020)

[No abstract available]

Detailed reference viewed: 27 (1 ULiège)
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See detailInherited CDH1 pathogenic variant: is there a place for surveillance of esophageal gastric inlet patch?
Leclercq, Philippe; Jadot, V.; Bours, Vincent ULiege et al

in Therapeutic Advances in Gastroenterology (2020), 13

[No abstract available]

Detailed reference viewed: 18 (2 ULiège)
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See detailNeurodevelopmental problems of unaccompanied refugee and migrant children: a new challenge for pediatric neurologists
Fazzi, Elisa; Korff, Christian M.; Bernabe Gelot, Antoinette et al

in Developmental Medicine and Child Neurology (2019), 61(11), 1348

Detailed reference viewed: 37 (3 ULiège)
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See detailImmune evasion before tumour invasion in early lung squamous carcinogenesis
Mascaux, C.; Angelova, M.; Vasaturo, A. et al

in Nature (2019), 571(7766), 570-575

Early detection and treatment are critical for improving the outcome of patients with cancer1. Understanding the largely uncharted biology of carcinogenesis requires deciphering molecular processes in ... [more ▼]

Early detection and treatment are critical for improving the outcome of patients with cancer1. Understanding the largely uncharted biology of carcinogenesis requires deciphering molecular processes in premalignant lesions, and revealing the determinants of the intralesional immune reaction during cancer development. The adaptive immune response within tumours has previously been shown to be strongest at the earliest stage of carcinoma2,3. Here we show that immune activation and immune escape occur before tumour invasion, and reveal the relevant immune biomarkers of the pre-invasive stages of carcinogenesis in the lung. We used gene-expression profiling and multispectral imaging to analyse a dataset of 9 morphological stages of the development of lung squamous cell carcinoma, which includes 122 well-annotated biopsies from 77 patients. We identified evolutionary trajectories of cancer and immune pathways that comprise (1) a linear increase in proliferation and DNA repair from normal to cancerous tissue; (2) a transitory increase of metabolism and early immune sensing, through the activation of resident immune cells, in low-grade pre-invasive lesions; (3) the activation of immune responses and immune escape through immune checkpoints and suppressive interleukins from high-grade pre-invasive lesions; and, ultimately, (4) the activation of the epithelial–mesenchymal transition in the invasive stage of cancer. We propose that carcinogenesis in the lung involves a dynamic co-evolution of pre-invasive bronchial cells and the immune response. These findings highlight the need to develop immune biomarkers for early detection as well as immunotherapy-based chemopreventive approaches for individuals who are at high risk of developing lung cancer. © 2019, The Author(s), under exclusive licence to Springer Nature Limited. [less ▲]

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See detailNo detection of methane on Mars from early ExoMars Trace Gas Orbiter observations
Korablev, O.; Vandaele, A. C.; Montmessin, F. et al

in Nature (2019), 568

The detection of methane on Mars has been interpreted as indicating that geochemical or biotic activities could persist on Mars today 1 . A number of different measurements of methane show evidence of ... [more ▼]

The detection of methane on Mars has been interpreted as indicating that geochemical or biotic activities could persist on Mars today 1 . A number of different measurements of methane show evidence of transient, locally elevated methane concentrations and seasonal variations in background methane concentrations 2–5 . These measurements, however, are difficult to reconcile with our current understanding of the chemistry and physics of the Martian atmosphere 6,7 , which—given methane’s lifetime of several centuries—predicts an even, well mixed distribution of methane 1,6,8 . Here we report highly sensitive measurements of the atmosphere of Mars in an attempt to detect methane, using the ACS and NOMAD instruments onboard the ESA-Roscosmos ExoMars Trace Gas Orbiter from April to August 2018. We did not detect any methane over a range of latitudes in both hemispheres, obtaining an upper limit for methane of about 0.05 parts per billion by volume, which is 10 to 100 times lower than previously reported positive detections 2,4 . We suggest that reconciliation between the present findings and the background methane concentrations found in the Gale crater 4 would require an unknown process that can rapidly remove or sequester methane from the lower atmosphere before it spreads globally. [less ▲]

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See detailFurther Discussion of the Speeds of Light, Gravitational Waves, and Gravity
Helbig, Phillip ULiege

in Observatory (2019), 139(1268), 5-7

This is a "correspondence" piece, not a regular article per se, i.e. a "letter to the editor" in the original sense of the term. They are refereed, though; I've received comments on my own such ... [more ▼]

This is a "correspondence" piece, not a regular article per se, i.e. a "letter to the editor" in the original sense of the term. They are refereed, though; I've received comments on my own such contributions, and refereed those of others. [less ▲]

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See detailThe centrosome protein AKNA regulates neurogenesis via microtubule organization
Camargo Ortega, G.; Falk, S.; Johansson, P. A. et al

in Nature (2019), 567(7746), 113-117

The expansion of brain size is accompanied by a relative enlargement of the subventricular zone during development. Epithelial-like neural stem cells divide in the ventricular zone at the ventricles of ... [more ▼]

The expansion of brain size is accompanied by a relative enlargement of the subventricular zone during development. Epithelial-like neural stem cells divide in the ventricular zone at the ventricles of the embryonic brain, self-renew and generate basal progenitors 1 that delaminate and settle in the subventricular zone in enlarged brain regions 2 . The length of time that cells stay in the subventricular zone is essential for controlling further amplification and fate determination. Here we show that the interphase centrosome protein AKNA has a key role in this process. AKNA localizes at the subdistal appendages of the mother centriole in specific subtypes of neural stem cells, and in almost all basal progenitors. This protein is necessary and sufficient to organize centrosomal microtubules, and promote their nucleation and growth. These features of AKNA are important for mediating the delamination process in the formation of the subventricular zone. Moreover, AKNA regulates the exit from the subventricular zone, which reveals the pivotal role of centrosomal microtubule organization in enabling cells to both enter and remain in the subventricular zone. The epithelial-to-mesenchymal transition is also regulated by AKNA in other epithelial cells, demonstrating its general importance for the control of cell delamination. © 2019, The Author(s), under exclusive licence to Springer Nature Limited. [less ▲]

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See detailNew equation to estimate glomerular filtration rate in China: a reference issue
DELANAYE, Pierre ULiege; Pottel, Hans ULiege

in Kidney International (2019), 96(2), 521

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See detailReply letter to the comment of Christmann V on 2018 ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Calcium, phosphorus and magnesium
Mihatsch, W.; Fewtrell, M.; Goulet, O. et al

in Clinical Nutrition (2019), 38(5), 2465-2466

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See detailChallenging transitions.
Wasalathanthri, Niluka D.; Syed-Shan-e-Ali, Zaïdi ULiege; Mahrt, Elena et al

in Science (2019), 363(6422), 24-26

We asked young scientists these questions: Have you ever encountered a particularly stark difference between an old and new position in your education or career? What was the difference between the ... [more ▼]

We asked young scientists these questions: Have you ever encountered a particularly stark difference between an old and new position in your education or career? What was the difference between the positions, and what advice would you give to someone making a similar transition? Here, respondents share the challenges they faced when they took on new responsibilities and roles, changed fields, or moved to new places. To others in similar situations, they advise: Be confident, prepared, and patient; communicate; and always ask for help when needed. —Jennifer Sills [less ▲]

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See detailEnergy expenditure of nursing home residents and participation in exercise classes: an analysis of the SENIOR cohort
Charles, Alexia ULiege; Buckinx, Fanny ULiege; Mouton, Alexandre ULiege et al

in Journal of the American Medical Directors Association (2019), 20(9), 1183-1184

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See detailSilencing an essential gene involved in infestation and digestion in grain aphid through plant-mediated RNA interference generates aphid-resistant wheat plants
Sun, Y.; Sparks, C.; Jones, H. et al

in Plant Biotechnology Journal (2019), 17(5), 852-854

[No abstract available]

Detailed reference viewed: 23 (2 ULiège)
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See detailLetter to the editor - Reply
Pariente, B.; Louis, Edouard ULiege

in Clinical Gastroenterology and Hepatology (2019), 17(12), 2623

[No abstract available]

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See detailSarcopenia: Performance of the SARC-F Questionnaire According to the European Consensus Criteria, EWGSOP1 and EWGSOP2
Hajaoui, Manon; Locquet, Médéa ULiege; Beaudart, Charlotte ULiege et al

in Journal of the American Medical Directors Association (2019), 20(9), 1182-1183

[No abstract available]

Detailed reference viewed: 33 (2 ULiège)
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See detailComment on: Efficacy of Curcumin and Boswellia for knee osteoarthritis: Systematic review and meta-analysis
Mobasheri, Ali; Henrotin, Yves ULiege

in Seminars in Arthritis and Rheumatism (2019), 48(4), 25-26

[No abstract available]

Detailed reference viewed: 32 (1 ULiège)
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See detailThe Big Bang: who really first suggested it?
Helbig, Phillip ULiege

in Observatory (2018), 138(1267), 305--306

While it is now generally well known that Edgar Allan Poe was the first to correctly explain Olbers's paradox, that is technically different than his Big Bang theory, despite the impressive list of ... [more ▼]

While it is now generally well known that Edgar Allan Poe was the first to correctly explain Olbers's paradox, that is technically different than his Big Bang theory, despite the impressive list of similarities with modern cosmology. The main difference is that Poe's explanation of Olbers's paradox is identical to the modern one, while his cosmology, though strikingly similar in many respects, is more speculation than science, although it turned out to be at least superficially right. [less ▲]

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See detailL’influence des techniques non-pharmacologiques sur le bien-être des patients aux soins intensifs : hypnose et réalité virtuelle
Rousseaux, Floriane ULiege

in HEGEL: Penser par Soi-Même (2018), 8(3),

Dans ce projet, nous nous intéressons à la comparaison de plusieurs techniques : l’hypnose (via un CD), l’immersion dans une réalité virtuelle (RV), via un casque et un film en 3D ainsi que la combinaison ... [more ▼]

Dans ce projet, nous nous intéressons à la comparaison de plusieurs techniques : l’hypnose (via un CD), l’immersion dans une réalité virtuelle (RV), via un casque et un film en 3D ainsi que la combinaison des deux, l'hypnose en réalité virtuelle (HRV) intégrées dans la prise en charge quotidienne des patients aux soins intensifs (USI). [less ▲]

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See detailA formula for confusion
Helbig, Phillip ULiege

in Observatory (2018), 138(1262), 22-25

The book contains a formula for cosmological "redshifts larger than one", namely the relativistic Doppler formula. It should be obvious that that formula cannot be correct, because it gives the velocity ... [more ▼]

The book contains a formula for cosmological "redshifts larger than one", namely the relativistic Doppler formula. It should be obvious that that formula cannot be correct, because it gives the velocity as a function of just the redshift; there are no cosmological parameters! Even the Hubble constant is absent. This implies that, even at arbitrarily high redshift, the velocity is independent of the cosmological model, and does not depend on even the Hubble constant (despite the fact that the latter is the proportionality constant in the velocity--distance relation!) while at the same time it is common knowledge that, except in the limit of small redshifts, the relation between observed and `absolute' or `physical' quantities depends on the cosmological model. Why does this misconception still persist? One reason might be that in practice cosmological velocities play no role in observational cosmology. [less ▲]

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See detailMeditation-induced modulation of brain response to transcranial magnetic stimulation
BODART, Olivier ULiege; Fecchio, M.; Massimini, Marcello et al

in Brain Stimulation (2018), 11(6), 1397-1400

[No abstract available]

Detailed reference viewed: 282 (34 ULiège)
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See detailLetters to the twenty-first century botanist. Second series: “what is a seed?”–3. How did we get there? Palaeobotany sheds light on the emergence of seed
Meyer-Berthaud, B.; Gerrienne, Philippe ULiege; Prestianni, Cyrille ULiege

in Botany Letters (2018), 165(3-4), 434-439

This paper discusses the main steps leading to the acquisition, during the Palaeozoic, of the seed habit. The earliest spermatophytes originated in the Late Devonian and produced small cupulate ovules ... [more ▼]

This paper discusses the main steps leading to the acquisition, during the Palaeozoic, of the seed habit. The earliest spermatophytes originated in the Late Devonian and produced small cupulate ovules characterized by an elaborated sporangial apex involved in pollination. The diversification of ovules during the Carboniferous led to a wider range of sizes and shapes, and an increasing importance of the integument. The earliest seeds containing embryos are reported in Carboniferous coniferophytes. © 2018, © 2018 Société botanique de France. [less ▲]

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See detailGLP-1 receptor agonists and cardiovascular protection: A class effect or not?
Scheen, André ULiege

in Diabetes and Metabolism (2018)

Detailed reference viewed: 22 (2 ULiège)
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See detailEditorial
Bourgeois, Marc ULiege

in Revue de Fiscalité Régionale et Locale (2018), 3

Detailed reference viewed: 17 (1 ULiège)
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See detailDo Positive Cardiovascular Outcomes Trials With New Glucose-Lowering Agents Overestimate Both Efficacy and Safety?
Scheen, André ULiege

in Circulation Research (2018), 123(4), 3-4

[No abstract available]

Detailed reference viewed: 22 (1 ULiège)
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See detailTheta network centrality correlates with tDCS response in disorders of consciousness
Thibaut, Aurore ULiege; Chennu, S.; Chatelle, Camille ULiege et al

in Brain Stimulation (2018), 11(6), 1407-1409

[No abstract available]

Detailed reference viewed: 38 (9 ULiège)
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See detailPlasma Klotho and Mortality Risk Among Nursing Home Residents: Results From the SENIOR Cohort
Buckinx, Fanny ULiege; Bruyère, Olivier ULiege; Reginster, Jean-Yves ULiege et al

in Journal of the American Medical Directors Association (2018), 19(12), 1139-1140

Detailed reference viewed: 30 (11 ULiège)
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See detailBrain Tissue-Volume Changes in Cosmonauts
Van Ombergen, A.; Jillings, S.; Jeurissen, B. et al

in New England Journal of Medicine (2018), 379(17), 1678-1680

[No abstract available]

Detailed reference viewed: 58 (11 ULiège)
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See detailNextGen Voices: Quality mentoring.
Segal, Lauren; Agarwal, Divyansh; Isaacson, Kyle J. et al

in Science (2018), 362(6410), 22-24

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See detailNextGen VOICES: A postdoc's purpose.
Brotherton, Carolyn Adams; Naz, Saima; Syed-Shan-e-Ali, Zaïdi ULiege et al

in Science (2018), 360(6384), 26-27

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See detailEducation for the future.
Pietrzak, Barbara; Ward, Adrian; Cheung, Man Kit et al

in Science (2018), 360(6396), 1409-1412

Detailed reference viewed: 24 (3 ULiège)
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See detailIMA commission on New Minerals, nomenclature and classification (CNMNC) Newsletter 43
Hålenius, U.; Hatert, Frédéric ULiege; Pasero, M. et al

in European Journal of Mineralogy (2018), 30(3), 647-652

[No abstract available]

Detailed reference viewed: 17 (1 ULiège)
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See detailPre-hospital transfusion of red blood cells in civilian trauma patients: what's next?
TONGLET, Martin ULiege; SWERTS, Frédéric ULiege; Mathonet, Pierre-Yves ULiege et al

in Transfusion Medicine (2018), 28(6), 457

[No abstract available]

Detailed reference viewed: 40 (1 ULiège)
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See detailIMA commission on new minerals, nomenclature and classification (CNMNC) NEWSLETTER 46: New minerals and nomenclature modifications approved in 2018
Hålenius, U.; Hatert, Frédéric ULiege; Pasero, M. et al

in European Journal of Mineralogy (2018), 30(6), 1181-1189

[No abstract available]

Detailed reference viewed: 22 (1 ULiège)
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See detailMathematical bias in assessment of placental residual blood volume
RIGO, Vincent ULiege; LEFEBVRE, Caroline ULiege; Kalenga, Masendu ULiege

in Journal of Perinatology (2017), 37(10), 1166

This letter suggest a new computation of the relative placental residual blood volume.

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See detailResurgence of Schmallenberg virus in Belgium after 3 years of epidemiological silence
Delooz, L; Saegerman, Claude ULiege; Quinet, C et al

in Transboundary and Emerging Diseases (2017), 64(5), 1641-1642

Detailed reference viewed: 65 (10 ULiège)
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See detailA Highly Durable RNAi Therapeutic Inhibitor of PCSK9
LANCELLOTTI, Patrizio ULiege; Oury, Cécile ULiege

in New England Journal of Medicine (2017), 376

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See detailComment on “Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone β-subunit gene”
VALDES SOCIN, Hernan Gonzalo ULiege; Daly, Adrian ULiege; BECKERS, Albert ULiege

in Korean Journal of Internal Medicine (2017), 32(3), 566-567

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See detailAdded value and limitations of electrical source localization
RIKIR, Estelle ULiege

in Epilepsia (2017), 58(1), 174-175

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See detailInternational endorsement of the ESCEO algorithm for management of knee osteoarthritis in clinical practice
Bruyère, Olivier ULiege; Cooper, Cyrus; Cutolo, Maurizio et al

in Seminars in Arthritis and Rheumatism (2017), 47(2), 10

Detailed reference viewed: 39 (6 ULiège)
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See detailDistinction between urine crystals by automated urine analyzer SediMAX conTRUST is specific but lacks of sensitivity.
Castiglione, Vincent ULiege; CAVALIER, Etienne ULiege; Diop, Coumba Souley ULiege et al

in Clinical Chemistry and Laboratory Medicine (2017)

Urine crystals are commonly encountered but few papers have been published about it while it is useful for patient’s follow-up, particularly the stone-formers. For the first time to our knowledge, we have ... [more ▼]

Urine crystals are commonly encountered but few papers have been published about it while it is useful for patient’s follow-up, particularly the stone-formers. For the first time to our knowledge, we have assessed the performance of an automated urine analyzer to identify and distinguish several types of crystals in a very large cohort of samples. We share in this report the results of method comparison of the SediMAX conTRUST with the polarized light microscopy which is the gold standard. We showed that the distinction between crystals and other urine elements was accurate. Negative predictive value was very good, but the positive predictive value was poor for most of crystals. The discrimination of different types of crystals between them by the automated urine analyzer still requires improvement to decrease reviewing rate and help clinician. [less ▲]

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See detailIs it possible to claim or refute sputum eosinophils ≥ 3% in asthmatics with sufficient accuracy using biomarkers?
Demarche, Sophie ULiege; Schleich, Florence ULiege; PAULUS, Virginie ULiege et al

in Respiratory Research (2017), 18(1), 133-139

The concept of asthma inflammatory phenotypes has proved to be important in predicting response to inhaled corticosteroids. Induced sputum, which has been pivotal in the development of the concept of ... [more ▼]

The concept of asthma inflammatory phenotypes has proved to be important in predicting response to inhaled corticosteroids. Induced sputum, which has been pivotal in the development of the concept of inflammatory phenotypes, is however not widely available. Several studies have proposed to use surrogate exhaled or blood biomarkers, like fractional exhaled nitric oxide (FENO), blood eosinophils and total serum immunoglobulin E (IgE). However, taken alone, each of these biomarkers has moderate accuracy to identify sputum eosinophilia. Here, we propose a new approach based on the likelihood ratio to study which thresholds of these biomarkers, taken alone or in combination, were able to rule in or rule out sputum eosinophils ≥3%. We showed in a large population of 869 asthmatics that combining FENO, blood eosinophils and total serum IgE could accurately predict sputum eosinophils ≥ or <3% in 58% of our population. © 2017 The Author(s). [less ▲]

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See detailNewer GFR Estimating Equations Require Validation in Different Populations
DELANAYE, Pierre ULiege; Ebert, N; Pottel, Hans

in American Journal of Kidney Diseases (2017), 70(4), 586

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See detailTargeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides: reply.
Delierneux, Céline; Donis, Nathalie ULiege; Servais, Laurence ULiege et al

in Journal of Thrombosis and Haemostasis (2017)

We provide here a new set of data supporting the involvement of multiple platelet receptors in CpG ODN platelet activating effects. We observed some sequence-specific features of platelet responses to ... [more ▼]

We provide here a new set of data supporting the involvement of multiple platelet receptors in CpG ODN platelet activating effects. We observed some sequence-specific features of platelet responses to phosphorothioate-modified CpG ODNs types A, B, and C that could be useful for future development of safe therapeutic CpG ODNs. Additional investigations are needed in order to further delineate these sequence specificities, and to address the importance of higher-order structures, as well as of possible interactions with cofactors for the effects of CpG ODN on platelets. [less ▲]

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See detailTreatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women
Reginster, Jean-Yves ULiege; Rizzoli, R.; Kanis, J. A. et al

in Annals of Internal Medicine (2017), 167(12), 902-903

[No abstract available]

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See detailEditorial
Bourgeois, Marc ULiege

in Revue de Fiscalité Régionale et Locale (2017), 2017-1

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See detailMerged heme and non-heme manganese cofactors for a dual antioxidant surveillance in photosynthetic organisms
Squarcina, A.; Sorarù, A.; Rigodanza, F. et al

in ACS Catalysis (2017), 7(3), 1971-1976

The coupling of a polycationic Mn(III)-porphyrin, with a dinuclear Mn2(II,II)L2 core (HL = 2-{[[di(2-pyridyl)methyl](methyl)amino]-methyl}phenol), results in a dual Superoxide Dismutase (SOD) and Catalase ... [more ▼]

The coupling of a polycationic Mn(III)-porphyrin, with a dinuclear Mn2(II,II)L2 core (HL = 2-{[[di(2-pyridyl)methyl](methyl)amino]-methyl}phenol), results in a dual Superoxide Dismutase (SOD) and Catalase (CAT) functional analogue, Mn2L2Pn+, enabling a detoxification cascade of the superoxide anion and hydrogen peroxide into benign H2O and O2. The SOD/CAT artificial manifolds, joined in one asset, exhibit a peak catalytic performance under physiological conditions, with log kcat(O2 •-) ≥ 7 and kcat(H2O2)/KM = 1890. The dual-enzyme (dizyme) concept allows for a builtin self-protection against the irreversible bleaching of the porphyrin unit (>75% protection), readily induced by H2O2 (200 μM, 20 equiv, in buffer solution, pH 7.8). We show herein that incubation of the photosynthetic green algae, Chlamydomonas reinhardtii, with the synthetic dizyme (as low as 0.1 μM), prevents H2O2 accumulation under high-light illumination conditions, thus providing antioxidant surveillance and photoprotection. (Chemical Equation Presented). © 2017 American Chemical Society. [less ▲]

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See detailpH and Not Cell Morphology Modulate pLIP2 Induction in the Dimorphic Yeast Yarrowia lipolytica
Sassi, Hosni ULiege; Delvigne, Frank ULiege; Kallel, H. et al

in Current Microbiology (2017), 74(3), 413-417

The dimorphic yeast Yarrowia lipolytica has become an emerging cell factory for recombinant proteins production. Expression vectors involving LIP2 promoter (pLIP2) have been developed and used ... [more ▼]

The dimorphic yeast Yarrowia lipolytica has become an emerging cell factory for recombinant proteins production. Expression vectors involving LIP2 promoter (pLIP2) have been developed and used successfully. However, the relationship between dimorphic transition (i.e., cell morphology) and pLIP2 regulation is still unclear and must be assessed to improve process robustness. This requests to discriminate the effect of cell morphology from that of effectors, such as pH, that trigger the dimorphic transition. This was performed using gene reporter system based on β-galactosidase activity and DsRed fluorescence, single-cell analysis by flow cytometry, and quantification of gene expression. Our results clearly pointed out that cell morphology has not effect on the regulation of pLIP2. By contrast, pH modification yielded to phenotypic heterogeneity, potentially leading to a lack of robustness of the cell population. Taken altogether, our results demonstrated that, under appropriate environmental conditions (e.g., pH being an important factor), Y. lipolytica could be considered as a robust and reliable host for recombinant protein production. © 2017, Springer Science+Business Media New York. [less ▲]

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See detailExercise Echocardiography in Aortic Stenosis: A Happy End?
Lancellotti, Patrizio ULiege; Sugimoto, T.; DULGHERU, Raluca Elena ULiege

in JACC. Cardiovascular Imaging (2017), 10(10), 1208-1209

[No abstract available]

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See detailEvaluation of fascial manipulation in carpal tunnel syndrome: A pilot randomized clinical trial
Pintucci, M.; Imamura, M.; Thibaut, Aurore ULiege et al

in European Journal of Physical and Rehabilitation Medicine (2017), 53(4), 630-632

[No abstract available]

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See detailRepeated stimulation of the posterior parietal cortex in patients in minimally conscious state: A sham-controlled randomized clinical trial
Huang, W.; Wannez, Sarah ULiege; Fregni, F. et al

in Brain Stimulation (2017), 10(3), 718-720

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See detailAnalysing hypoglycin A, methylenecyclopropylacetic acid conjugates and acylcarnitines in blood to confirm the diagnosis and improve our understanding of atypical myopathy
Votion, Dominique ULiege

in Equine Veterinary Education (2016), doi: 10.1111/eve.12617

Owing to recent methodological validation studies, we have now the opportunity to determine hypoglycin A, methylenecyclopropylacetic acid–carnitine and acylcarnitines concentrations in equine serum. These ... [more ▼]

Owing to recent methodological validation studies, we have now the opportunity to determine hypoglycin A, methylenecyclopropylacetic acid–carnitine and acylcarnitines concentrations in equine serum. These analytes are essential to confirm the diagnosis of atypical myopathy but also to improve our understanding of the pathophysiology of the disease. In particular, they might help elucidate why some horses seem more resistant to hypoglycin A poisoning. [less ▲]

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See detailKidney-Failure Risk Projection for the Living Kidney-Donor candidate.
DELANAYE, Pierre ULiege; Glassock, Richard

in New England Journal of Medicine (2016), 374(21), 2093-2094

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See detailConcordance between Iothalamate and Iohexol Plasma Clearance
DELANAYE, Pierre ULiege; LE GOFF, Caroline ULiege; JOURET, François ULiege et al

in American Journal of Kidney Diseases (2016), 68(2), 329-330

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See detailReference Method and Reference Material Are Necessary Tools to Reveal the Variability of Cystatin C Assays
Bargnoux, Anne-Sophie; Kuster, Nils; Delatour, Vincent et al

in Archives of Pathology and Laboratory Medicine (2016), 140(2), 117-118

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See detailManaging Chronic Kidney Disease in Older People--Reply
Glassock, rj; DELANAYE, Pierre ULiege; El-Nahas, M

in JAMA: Journal of the American Medical Association (2016), 315(3),

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See detailCognitive Behavioral Therapy with Daily Mindfulness Training: a Case Report of Comorbid Binge Eating and Bipolar Disorders
Ruffault, Alexis ULiege; Grégoire, S.; Hendrickson, K. et al

in Mindfulness (2016), 7(2), 573-576

[No abstract available]

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See detailTowards new methods of diagnosis in disorders of consciousness – Authors' reply
Di Perri, Carol ULiege; Thibaut, Aurore ULiege; Heine, Lizette ULiege et al

in Lancet Neurology (2016), 15(11), 1115-1116

[No abstract available]

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See detailDonor Age in Liver Transplantation: Donation after Circulatory Death.
DETRY, Olivier ULiege

in Journal of the American College of Surgeons (2015), 221(3), 779

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See detailCosmology and cosmogony
Helbig, Phillip ULiege

in Observatory (2015), 135(1247), 218-220

`Cosmogony' now refers to the origin of the universe or, most of the time, to the origin of planetary systems. The latter meaning came about because until relatively recent times it was believed that the ... [more ▼]

`Cosmogony' now refers to the origin of the universe or, most of the time, to the origin of planetary systems. The latter meaning came about because until relatively recent times it was believed that the cosmos is not much larger than the solar system. Thus, the original meaning of `study of the origin of the universe' also automatically meant `study of the origin of the solar system'. The latter meaning was expanded to include the study of the origin of other planetary systems when it was realized that these exists, while the original, basic meaning regarding the origin of the universe is now usually considered to be part of cosmology. [less ▲]

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See detailLong-term safety follow-up of a randomized trial of darbepoetin alpha and intravenous iron following autologous hematopoietic cell transplantation.
JASPERS, Aurélie ULiege; Baron, Frédéric ULiege; Maertens, Johan et al

in American Journal of Hematology (2015), 90(7), 133-4

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See detailL’âgisme et ses conséquences en oncologie
Schroyen, Sarah ULiege

in Onco-Hémato (2015), 3

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See detailLetter to editor-Comparative biochemical analysis after steam pretreatments of lignocellulosic biomass from six combined morphological parts of Williams Cavendish banana plant (Triploid Musa AAA group)
Kamdem, Irenée ULiege

in Waste Management and Research: the Journal of the International Solid Wastes and Public Cleansing Association (2015)

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See detailMethods for calculating growth velocity for VLBW infants
SENTERRE, Thibault ULiege

in Pediatrics (2015), 136(1), 8469757

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See detailThe myth of the future burden of CKD in United States.
DELANAYE, Pierre ULiege; El-Nahas, M; Glassock, RJ

in American Journal of Kidney Diseases (2015), 66(1), 171-172

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See detailimpact of stopping vitamin K antagonist therapy on concentrations of dephospho-uncarboxylated Matrix Gla protein
DELANAYE, Pierre ULiege; DUBOIS, Bernard ULiege; LUKAS, Pierre ULiege et al

in Clinical Chemistry and Laboratory Medicine (2015), 53(8), 191-193

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See detailOpen Thought. Minimal Music: a Case for Actor-Network Theory?
Levaux, Christophe ULiege

in Minimal Matters. Newsletter of the Society for Minimalist Music (2015)

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See detailVitamin D status in critically ill patients: back to basics!
ROUSSEAU, Anne-Françoise ULiege; CAVALIER, Etienne ULiege

in Critical Care (2014), 18(6), 611

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See detailA classic problem concluded
Helbig, Phillip ULiege

in Observatory (2014), 134(1240), 138-139

M. Beech gave an interesting historical review of an intriguing question (The Observatory, 133, p. 311, No. 1237 (December 2013)), but it was missing the one reference I would have thought of first.

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See detailComment on : “Do Sector-Wide Approaches for health aid delivery lead to ‘donorflight’? A comparison of 46 low-income countries” by Rohan Sweeney, Duncan Mortimer, and David W. Johnston
Paul, Elisabeth ULiege; Porignon, Denis ULiege; Dujardin Bruno, et al

in Social Science and Medicine (2014)

Critique of a published paper on health SWAps. We question the core of the article, as it is to us based on wrong assumptions, a maladapted design, questionable data, and it leads to dangerous conclusions.

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See detailReply to Mr. Osmaston concerning the nature of the redshift
Helbig, Phillip ULiege

in Observatory (2014), 134(1236), 76-76

This is my reply to a reply by Osmaston (The Observatory, 134, p 33, No 1238 (February 2014)) to my comment (The Observatory, 133, p 294, No 1236 (October 2013)) on a comment by Osmaston (from the report ... [more ▼]

This is my reply to a reply by Osmaston (The Observatory, 134, p 33, No 1238 (February 2014)) to my comment (The Observatory, 133, p 294, No 1236 (October 2013)) on a comment by Osmaston (from the report on the meeting) (The Observatory, 133, p 136, No 1234 (June 2013)) on a talk by Andrew Liddle (The Observatory, 133, p 135, No 1234 (June 2013)) at an RAS meeting. [less ▲]

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See detailCreatinine-based GFR estimating equations in kidney transplant recipients
DELANAYE, Pierre ULiege

in American Journal of Kidney Diseases (2014), 64(5), 818

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See detailCosmic Confusion
Helbig, Phillip ULiege

in Observatory (2013), 133(1236), 294-295

This is a comment on a comment (from the report on the meeting) by Osmaston on a talk by Andrew Liddle (The Observatory, 133, p. 136, No. 1234 (June 2013)) at an RAS meeting.

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See detailRole of folate receptor autoantibodies in infantile autism
RAMAEKERS, Vincent ULiege; Quadros, E. V.; Sequeira, J. M.

in Molecular Psychiatry (2013), 18(3), 270-1

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See detailTolvaptan in autosomal dominant polycystic kidney disease.
JOURET, François ULiege; Krzesinski, Jean-Marie ULiege

in New England Journal of Medicine (2013), 368(13), 1258-9

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See detailResearch and innovations committee a new outlook for the European Association of Cardiovascular Imaging (EACVI).
Donal, Erwan; Badano, Luigi; Habib, Gilbert et al

in European Heart Journal - Cardiovascular Imaging (2013), 14(4), 400

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See detailMitral regurgitation after transcatheter aortic valve replacement: Does the prosthesis matter?
Unger, Philippe; Dedobbeleer, Chantal; Vanden Eynden, Frederic et al

in International Journal of Cardiology (2013)

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See detailLetter to the editor: Definition of moderate ischemic mitral regurgitation: It's time to speak the same language
Fattouch, K.; Punjabi, P.; Lancellotti, Patrizio ULiege

in Perfusion (2013), 28(2), 173-175

[No abstract available]

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See detailReply to the Editor
SEGHAYE, Marie-Christine ULiege

in Annals of Thoracic Surgery (2012), 94(5), 1787

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See detailWhy stop at 2/3?
Helbig, Phillip ULiege

in Observatory (2012), 132(1229), 267-267

This is a comment on a comment by Barber (from the report on the meeting) on a talk by Mike Turner (The Observatory, 132, p. 64, No. 1227 (April 2012)) at an RAS meeting.

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See detailDetection of Thermal Emission from a Super-Earth
Demory, Brice*-Olivier; Gillon, Michaël ULiege; Seager, Sara et al

in Astrophysical Journal. Letters (2012), 751(2), 28

We report on the detection of infrared light from the super-Earth 55 Cnc e, based on four occultations obtained with Warm Spitzer at 4.5 microns. Our data analysis consists of a two-part process. In a ... [more ▼]

We report on the detection of infrared light from the super-Earth 55 Cnc e, based on four occultations obtained with Warm Spitzer at 4.5 microns. Our data analysis consists of a two-part process. In a first step, we perform individual analyses of each dataset and compare several baseline models to optimally account for the systematics affecting each lightcurve. We apply independent photometric correction techniques, including polynomial detrending and pixel-mapping, that yield consistent results at the 1-sigma level. In a second step, we perform a global MCMC analysis including all four datasets, that yields an occultation depth of 131+-28ppm, translating to a brightness temperature of 2360+-300 K in the IRAC-4.5 micron channel. This occultation depth suggests a low Bond albedo coupled to an inefficient heat transport from the planetary dayside to the nightside, or else possibly that the 4.5-micron observations probe atmospheric layers that are hotter than the maximum equilibrium temperature (i.e., a thermal inversion layer or a deep hot layer). The measured occultation phase and duration are consistent with a circular orbit and improves the 3-sigma upper limit on 55 Cnc e's orbital eccentricity from 0.25 to 0.06. [less ▲]

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See detailWhich law is Hubble's law?
Helbig, Phillip ULiege

in Observatory (2012), 132(1228), 183-184

This is a reply to Virginia Trimble's reply (The Observatory, 132, p. 33, No. 1226 (February 2012)) to an article by Nussbaumer & Bieri (The Observatory, 131, p. 394, No. 1225 (December 2011)) concerning ... [more ▼]

This is a reply to Virginia Trimble's reply (The Observatory, 132, p. 33, No. 1226 (February 2012)) to an article by Nussbaumer & Bieri (The Observatory, 131, p. 394, No. 1225 (December 2011)) concerning some of the history of the term "Hubble's Law" and related matters. (Note: The reference to Trimble's reply is mistakenly assigned to p. 40 (the last page) rather than p. 33 (the first page) in the PDF version, but is correct in the printed version.) [less ▲]

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See detailFood safety body is bound to draw fire
Hendrickx, Kim ULiege; Penders, Bart

in Nature (2012), 485(31 May 2012), 582

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