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See detailRecherches sur le Site de Germigny-des-Prés (Loiret, Centre Val de Loire) en 2019
Van Wersch, Line ULiege; Henrion, Fabrice

in Archéologie Médiévale (in press)

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See detailRecherches sur le Site de Germigny-des-Prés en 2019
Van Wersch, Line ULiege; Henrion, Fabrice

in Bilan scientifique de la région Centre-Val de Loire (in press), 2019

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See detailCOVID-19: An Accelerator for Sustainable and Smart Urban Transitions?
Clement, Jessica ULiege; Crutzen, Nathalie ULiege

in Georgetown Journal of International Affairs (2021)

When envisioning a post-pandemic world, a window of opportunity to couple economic recovery with sustainability measures presents itself. This is particularly the case for cities, many of which have ... [more ▼]

When envisioning a post-pandemic world, a window of opportunity to couple economic recovery with sustainability measures presents itself. This is particularly the case for cities, many of which have negative environmental impacts but also act as engines of change at both a local and global scale. As a result, COVID-19 recovery packages have the momentum to accelerate transitions to sustainable and smart cities. [less ▲]

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See detailEn marge de la pandémie
Bouhon, Frédéric ULiege; Jousten, Andy ULiege; Miny, Xavier ULiege

in Journal des Tribunaux (2021)

Les auteurs synthétisent ici, en quelques pages, leur récent rapport "Droit d’exception : une perspective de droit comparé. Belgique : entre absence d’état d’exception, pouvoirs de police et pouvoirs ... [more ▼]

Les auteurs synthétisent ici, en quelques pages, leur récent rapport "Droit d’exception : une perspective de droit comparé. Belgique : entre absence d’état d’exception, pouvoirs de police et pouvoirs spéciaux". Ce dernier document a été rédigé sous les auspices du Service de recherche du Parlement européen (disponible en libre accès sur ce lien: https://urlz.fr/fJKn). Le texte proposé dans les colonnes du JT revient ainsi sur les principaux développements et enseignements de l'étude. [less ▲]

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See detailUsing simulation to assess patient's self-triage for unscheduled urgent care : the ODISSEE platform
GILBERT, Allison ULiege; BRASSEUR, Edmond ULiege; François, Sophie et al

in Advances in Simulation (2021), 6(Supplement 2),

Development of new technologies in the healthcare system is a current and exciting concern for many physicians. Management of unscheduled primary and emergency care is one of the many areas in which ... [more ▼]

Development of new technologies in the healthcare system is a current and exciting concern for many physicians. Management of unscheduled primary and emergency care is one of the many areas in which technological innovations are starting to emerge. We developed a French-language self-triage platform, called ODISSEE (Outil Décisionnel et Informatif des Structures de Soins Efficientes Exis- tantes), based on previously validated protocols for the triage of out- of-hours primary care calls. We aim to demonstrate its validity and safety as regards patients level of care needs using simulated triage.Development of new technologies in the healthcare system is a current and exciting concern for many physicians. Management of unscheduled primary and emergency care is one of the many areas in which technological innovations are starting to emerge. We developed a French-language self-triage platform, called ODISSEE (Outil Décisionnel et Informatif des Structures de Soins Efficientes Exis- tantes), based on previously validated protocols for the triage of out- of-hours primary care calls. We aim to demonstrate its validity and safety as regards patients level of care needs using simulated triage. [less ▲]

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See detailPrévenir l'apparition des troubles myofonctionnels orofaciaux
Warnier, Morgane ULiege

in Cahiers de l'ASELF (2021), 18(1), 1-2

How does the Speech and Language Pathologist help prevent the onset of orofacial myofunctional disorders ?

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See detailCovid 19 : Vidange de la culture ou opportunité à l’interculturalité ?
Hakizumukama, Alexis ULiege

in Question(s) de Management (2021), 31(1), 151-206

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See detailQuelques représentations de la Bruxelles populaire et dialectale dans la littérature, le théâtre et la bande dessinée
Delvaux, Julien ULiege

in Publications scientifiques de la Faculté de philologie (2021), 1

Conçu en complément de l’article « Artifices de langage et adaptations de classiques français : fabrique et mémoire d'une Bruxelles populaire » publié quelques semaines auparavant par le Centre ... [more ▼]

Conçu en complément de l’article « Artifices de langage et adaptations de classiques français : fabrique et mémoire d'une Bruxelles populaire » publié quelques semaines auparavant par le Centre Interuniversitaire d’Études françaises de l’Université Eötvös Loránd Budapest, cet article court commence par résumer quelques éléments relatifs à la question des langues et des dialectes dans la capitale. Il évoque ensuite plusieurs expressions populaires de celle-ci en littérature, théâtre et bande dessinée, qui reposent sur des pratiques langagières à la fois typiques et expressément réélaborées. [less ▲]

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See detail"Prendre du recul par rapport à l'enseignement à distance"
Defays, Jean-Marc ULiege

in Français dans le Monde: Revue Internationale et Francophone des Professeurs de Français (2021), (432), 29

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See detail398P/Boattini a new JFC carbon-chain poor comet
Jehin, Emmanuel ULiege; Moulane, Youssef ULiege; Manfroid, Jean ULiege et al

in The Astronomer's Telegram (2020), 14251

E. Jehin, Y. Moulane, J. Manfroid, F. Pozuelos, M. Ferrais, D. Hutsemekers (STAR Institute, University of Liege, Belgium) report that they obtained with TRAPPIST-North (code=Z53, at Oukaimeden Observatory ... [more ▼]

E. Jehin, Y. Moulane, J. Manfroid, F. Pozuelos, M. Ferrais, D. Hutsemekers (STAR Institute, University of Liege, Belgium) report that they obtained with TRAPPIST-North (code=Z53, at Oukaimeden Observatory, Morocco) 0.6-m robotic telescope, three sets of observations of the recently recovered comet 398P/Boattini (= 2009 Q4 = 2020 P2, CBET 4829) on November 10, 15 and 20 UT under photometric conditions using HB cometary narrowband filters (Farnham et al. 2000). [less ▲]

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See detailInfluence of low-intensity pulsed ultrasound on bone repair upon irradiation: a histomorphometric study in rabbits.
Biewer, Robert ULiege; Kleine Borgmann, Felix; Rompen, Eric ULiege et al

in International Poster Journal of Dentistry and Oral Medicine (2020), 22(4), 2350

The present study evaluated the influence of LIPUS on regeneration processes of bone defects below the critical size in irradiated and non-irradiated rabbit tibia. The study was based on a total of six ... [more ▼]

The present study evaluated the influence of LIPUS on regeneration processes of bone defects below the critical size in irradiated and non-irradiated rabbit tibia. The study was based on a total of six white New-Zealand adult female rabbits. Apart from surgery to create bone defects on all tibiae, the following four treatments were randomly added on: (1) C group: only the surgical procedure was applied with no additional treatment, serving as the control, (2) R group, the irradiated side received 15 Gy in single dose, (3) US group, treated with LIPUS, and (4) R+US group, irradiated with 15 Gy and treated with LIPUS (n=6 defects per group). The surgery control samples showed 83.10% ± 17.79% of bone repair after 9 weeks, while the irradiated bone had significantly (p < 0.5) less regenerated during the same period (66.42% ± 29.36%). LIPUS treatment on irradiated bones performed a 79.21% ± 21.07% bone fill and could not significantly (p > 0.05) improve the response compared to the non-treated irradiated specimens. In the irradiated bones, ultrasound treatment produced only 3.89% less new bone compared to the untreated control group; this repair is insignificantly lower than the natural bone healing in the untreated control group. LIPUS treatment on non-irradiated bone, however, showed bone formations beyond the size defect (115.91% ± 33.69%), highly significantly different when compared to the control group or any irradiated group. It is noteworthy that the application of ultrasound to healthy bone produced highly significantly enhanced bone formations, with 36.70% more regenerated bone when comparing the same application on irradiated bone (79.21% ± 21.07%). LIPUS vibration stimuli may be considered as a promising complementary treatment approach in non-irradiated bone regeneration procedures to shorten the treatment and to enhance the bone healing. In irradiated bones, the effect of ultrasound application is less apparent and further studies are needed to refine the dynamics of the present results. [less ▲]

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See detailFrom Labyrinth to Piano Key weirs: the story
Erpicum, Sébastien ULiege; Lempérière, François; Ouamane, Ahmed et al

in Hydrolink (2020), 4(2020), 126-127

Labyrinth weirs are an efficient solution for free surface flow whose development has been initially favored by a close collaboration between research and industry in the United States. Piano Key weirs ... [more ▼]

Labyrinth weirs are an efficient solution for free surface flow whose development has been initially favored by a close collaboration between research and industry in the United States. Piano Key weirs improve the traditional Labyrinth concept and have been developed with the same collaborative spirit at an international level. Both structures have a huge potential of development and application worldwide, which has been exploited yet only in a few countries. [less ▲]

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See detailCoronavirus : La distanciation sociale, levier d’un management par intelligence collective
Hakizumukama, Alexis ULiege

in Question(s) de Management (2020), 30(4), 107-150

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See detailTRAPPIST comet production rates: 88/Howell, C/2020 M3 (ATLAS), C/2020 S3 (Erasmus), 156P/Russell-LINEAR
Jehin, Emmanuel ULiege; Moulane, Youssef ULiege; Manfroid, Jean ULiege et al

in The Astronomer's Telegram (2020), 14174

E. Jehin, Y. Moulane, J. Manfroid, F. Pozuelos, M. Ferrais, D. Hutsemekers (STAR Institute, University of Liege) report that they obtained from TRAPPIST-South (code=I40, Chile) and TRAPPIST-North (code ... [more ▼]

E. Jehin, Y. Moulane, J. Manfroid, F. Pozuelos, M. Ferrais, D. Hutsemekers (STAR Institute, University of Liege) report that they obtained from TRAPPIST-South (code=I40, Chile) and TRAPPIST-North (code=Z53, Morocco) 0.6-m robotic telescopes (Jehin el al. 2011) observations using HB narrowband filters (Farnham et al. 2000) for the following comets and computed preliminary production rates at 10.000 km using a Haser Model (Vp=Vd=1km/s) (Haser 1957). [less ▲]

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See detailTRAPPIST comet production rates: 88/Howell, C/2020 M3 (ATLAS), C/2020 S3 (Erasmus), 156P/Russell-LINEAR
Jehin, Emmanuel ULiege; Moulane, Youssef ULiege; Manfroid, Jean ULiege et al

in The Astronomer's Telegram (2020), 14101

E. Jehin, Y. Moulane, J. Manfroid, F. Pozuelos, D. Hutsemekers (STAR Institute, University of Liege) report that they obtained from TRAPPIST-South (I40, Chile) and TRAPPIST-North (Z53, Morocco) 0.6-m ... [more ▼]

E. Jehin, Y. Moulane, J. Manfroid, F. Pozuelos, D. Hutsemekers (STAR Institute, University of Liege) report that they obtained from TRAPPIST-South (I40, Chile) and TRAPPIST-North (Z53, Morocco) 0.6-m robotic telescopes (Jehin el al. 2011) observations using HB narrowband filters (Farnham et al. 2000) for the following comets and computed preliminary production rates at 10.000 km using a Haser Model (Vp=Vd=1km/s) (Haser 1957). [less ▲]

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See detailSMA: REGISTRIES, BIOMARKERS & OUTCOME MEASURES: P.191 Preliminary data for the cost-effectiveness assessment of the newborn screening for SMA in Belgium
Dangouloff, Tamara ULiege; Servais, Laurent ULiege; Hiligsmann, Mickaël ULiege

in Neuromuscular Disorders (2020)

Neonatal screening is becoming increasingly important in the spinal muscular atrophy (SMA) landscape. Yet there is a growing set of evidences that early pre-symptomatic management is much more efficient ... [more ▼]

Neonatal screening is becoming increasingly important in the spinal muscular atrophy (SMA) landscape. Yet there is a growing set of evidences that early pre-symptomatic management is much more efficient than post- symptomatic treatment, there is however no information available on the cost-effectiveness of SMA newborn screening (NBS). Such health economic analysis is nevertheless very important to convince policy makers to allocate funds for NBS. We will present the health-economic data of pre-symptomatic and post-symptomatic treated patients in Belgium that will further be used to assess the cost-effectiveness of NBS. Between March 2018 and February 2020, screening was conducted among 71,000 newborns, among which 9 were detected with SMA. All but one identified patients were treated before the onset of symptoms: 5 with nusinersen (one was mildly symptomatic at the time of treatment), 2 with Zolgensma, 1 with Risdiplam and the last one to be determined. Survival, costs and quality of life of these 9 patients (aged between 10 days and 18 months) are currently prospectively collected. In addition, data from 3 additional asymptomatic patients who were siblings of affected children are also collected. Survival, health care resources consumption and quality of life data have also been collected on symptomatic treated and untreated patients. For untreated patients, we collected prospectively the data during two years in 81 patients (53 patients with SMA Type 2, 9 non-ambulant with SMA Type 3 and 19 ambulant with SMA Type 3). We are also collecting similar data prospectively in 30 symptomatic patients treated with nusinersen and 2 untreated patients, aged between 4 months and 60 years (9 patients with SMA 1, 14 patients with SMA 2, and 9 patients with SMA 3). Two-thirds of these patients already have at least 2 years of follow-up. Using these three sets of data, we are currently developing a model to assess the cost-effectiveness of newborn screening for SMA. We will present the preliminary results issued from this model. [less ▲]

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See detailVitamin D deficiency and the COVID-19 pandemic.
Zemb, Patrick; Bergman, Peter; Camargo, Carlos A. Jr et al

in Journal of global antimicrobial resistance (2020), 22

• Vitamin D deficiency is very common. • Randomised controlled trials showed that vitamin D decreases acute respiratory infections (ARIs). • Vitamin D deficiency is an easily modifiable factor of ARIs. • ... [more ▼]

• Vitamin D deficiency is very common. • Randomised controlled trials showed that vitamin D decreases acute respiratory infections (ARIs). • Vitamin D deficiency is an easily modifiable factor of ARIs. • Daily vitamin D supplementation with moderate doses is safe and cheap. • Even a small decrease in COVID-19 infections would easily justify this intervention. [less ▲]

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See detailSpontaneous Tool Use by a Wild Black Lion Tamarin (Leontopithecus chrysopygus)
Kaisin, Olivier ULiege; Amaral, Rodrigo; Bufalo, Felipe et al

in International Journal of Primatology (2020)

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See detailLa fiscalité des ASBL et du secteur non marchand : les principales nouveautés
Garroy, Sabine ULiege; SOLDAI, Aurélie; DE NEYER, Camille et al

in Bulletin Social et Juridique (2020)

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See detailEntretien autour de l’ouvrage co-dirigé par E. Geerkens, N. Hatzfeld, I. Lespinet-Moret, X. Vigna (La Découverte, 2019)
Geerkens, Eric ULiege; Vigna, Xavier

in Historiens et Géographes (2020)

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See detailInvestigation of the temporal relationships between milk mid-infrared predicted biomarkers and lameness events in later lactation
Mineur, Axelle ULiege; Hammami, Hedi ULiege; Grelet, Clément ULiege et al

in Journal of Dairy Science (2020), 103(5), 4475-4482

This study reports on the exploration of temporal relationships between milk mid-infrared predicted biomarkers and lameness events. Lameness in dairy cows is an issue that can vary greatly in severity and ... [more ▼]

This study reports on the exploration of temporal relationships between milk mid-infrared predicted biomarkers and lameness events. Lameness in dairy cows is an issue that can vary greatly in severity and is of concern for both producers and consumers. Metabolic disorders are often associated with lameness. However, lameness can arise weeks or even months after the metabolic disorder, making the detection of causality difficult. We already use mid-infrared technology to predict major milk components, such as fat or protein, during routine milk recording and for milk payment. It was recently shown that this technology can also be used to predict novel biomarkers linked to metabolic disorders in cows, such as oleic acid (18:1 cis-9), β-hydroxybutyrate, acetone, and citrate in milk. We used these novel biomarkers as proxies for metabolic issues. Other studies have explored the possibility of using mid-infrared spectra to predict metabolic diseases and found it (potentially) usable for indicating classes of metabolic problems. We wanted to explore the possible relationship between mid-infrared-based metabolites and lameness over the course of lactation. In total, data were recorded from 6,292 cows on 161 farms in Austria. Lameness data were recorded between March 2014 and March 2015 and consisted of 37,555 records. Mid-infrared data were recorded between July and December 2014 and consisted of 9,152 records. Our approach consisted of fitting preadjustments to the data using fixed effects, computing pair-wise correlations, and finally applying polynomial smoothing of the correlations for a given biomarker at a certain month in lactation and the lameness events scored on severity scale from sound or non-lame (lameness score of 1) to severely lame (lameness score of 5) throughout the lactation. The final correlations between biomarkers and lameness scores were significant, but not high. However, for the results of the present study, we should not look at the correlations in terms of absolute values, but rather as indicators of a relationship through time. When doing so, we can see that metabolic problems occurring in mo 1 and 3 seem more linked to longterm effects on hoof and leg health than those in mo 2. However, the quantity (only 1 pair-wise correlation exceeded 1,000 observations) and the quality (due to limited data, no separation according to more metabolic-related diseases could be done) of the data should be improved. [less ▲]

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See detail« En solo mais pas seul » … il chante avec son « double holographique »
Renotte, Yvon ULiege

in Bulletin de l’université du 3e âge de Liège (2020), 2020/2(mars-avril), 28-29

Many so-called Holographic shows have appeared in recent years: W. Houston, La Callas, .... This is an abuse of language since they are not real holograms but projections of stereoscopic images using an ... [more ▼]

Many so-called Holographic shows have appeared in recent years: W. Houston, La Callas, .... This is an abuse of language since they are not real holograms but projections of stereoscopic images using an old technique, the Pepper's Ghost illusion "modernized" by use of the most sophisticated electronic imaging techniques which leads to stunning shows. [less ▲]

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See detailBrief interventions for improving adherence in schizophrenia: A pilot study using electronic medication event monitoring
Tessier, Arnaud; Dupuis, Maud; Baylé, Franck Jean et al

in Psychiatry Research (2020), 285

Poor medication adherence remains frequent in schizophrenia. The present study examined the efficacy of two month-long pilot interventions using the Medication Event Monitoring System (MEMS®). Thirty ... [more ▼]

Poor medication adherence remains frequent in schizophrenia. The present study examined the efficacy of two month-long pilot interventions using the Medication Event Monitoring System (MEMS®). Thirty-three outpatients at high risk for relapse were randomized to receive a smartphone-based intervention, a nurse-based intervention, or treatment as usual. All patients then used the MEMS® to objectively measure medication adherence over six months. No differences were observed in adherence measures or relapse rates across the three groups. When using electronic medication monitoring as an objective measure of adherence, easily-implemented interventions may not significantly improve adherence in patients at high risk for relapse. [less ▲]

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See detailMyopathie atypique et toxicité des samares: réponse de l'expert au courrier des lecteurs
Votion, Dominique ULiege

in Cheval Santé (2020), 126

Réponse via le courrier des lecteurs à diverses questions relatives à la toxicité des érables

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See detailBioactive glass particles and deproteinized bovine bone mineral as scaffold in bone tissue regeneration:effects of Minocycline-HCL.
Biewer, Robert ULiege; Van hede, Dorien ULiege; Kleine Borgmann, Felix et al

in Journal of Osseointegration (2020), 12(1), 18-19

Aim/Hypothesis: Bone tissue regeneration remains an important challenge in orthopaedic and maxillofacial surgery. The present study in rat was performed to determine if Minocycline could influence the ... [more ▼]

Aim/Hypothesis: Bone tissue regeneration remains an important challenge in orthopaedic and maxillofacial surgery. The present study in rat was performed to determine if Minocycline could influence the behavior of Deproteinized Bovine Bone Mineral (DBBM) and bioactive glass particles when used as scaffold for Guided Bone Regeneration (GBR). Minocycline is a wide spectrum antibiotic with demonstrated effects on bone formation, bone resorption and connective tissue breakdown. We chose to investigate this molecule in relation with bioactive glasses and DBBM, both important classes of bone grafting materials. Material and methods: Two completely occlusive titanium bone augmentation caps were placed on each side of the sagittal cranial suture of the rat calvaria. One was filled with bioactive glass particles (BioGran-Biomet 3i, Plam Beach, FL, USA) and the second with DBBM particles (Bio-Oss®–Geistlich, Wolhusen, Switzerland). Bone filler particles were mixed with blood, collected from the animal’s tail, and a drop of balanced salt solution in order to acquire a moldable consistency of the particles and a perfectly adapted fill of the regeneration chambers. In Minocycline-Cl group (n=10) bone grafts were additionally placed into a minocycline solution at 0.1 mg/ml prior placement. The study protocol included animal accommodation with water ad libitum, regular rat pellet with artificial light with a night and day cycle. All surgeries were conducted under strict aseptic conditions. For each observation time (4, 8 and 16 weeks) two calvaria were embedded in methyl methacrylate resin and cut in thin serial sections (100-200 µm), grounded and polished to a thickness of 20-40 µm. A Giemsa (Gross & Strunz, 1977), Paragon and a combination of Stevenel’s blue with Van Gieson staining was used for light microscopy. The remaining calvaria were fixed, decalcified in an EDTA solution at 0.2 M (pH 7.4) for 30 days and dehydrated in ascending ethanol series for 96 h. The paraffin embedded blocks were sectioned (5 µm) and either hematoxylin eosin (H&E) or Toluidine blue stained for the histologic analysis. Results: This study has confirmed osteoconductive and osteoinductive response of BioGran. The addition of Minocycline has hardly influenced the result positively. In contact with blood, BioGran underwent a surface modification in form of a calcium phosphate precipitate, quite similar in composition and structure to hydroxyapatite. Cracks in the outer shell were to be recognized and the silica core tended to disappear leaving a calcium phosphate pouch for future bone growth. Likewise, first signs of osteoinduction in the form of ectopic mineralization foci could be observed after just 4 weeks at some distance from BioGran particles. These ossification islets were lined by a layer of osteoblasts for centrifugal expansion. The osteoconductivity and predictability of Bio-Oss®, are well documented. Some studies however found that Bio-Oss® inhibited new bone formation or interfered with new bone generation especially when used as an onlay graft under totally occlusive capsules in a GTR model. Our observations were similar: the major part of the biomaterial particles was embedded in connective tissue. Most of the new bone regenerated were lamellar bone formations in close contact and bonded to the DBBM particles. Islands of spontaneous ossification suggesting some osteoinductive activities could only be observed in Bio-Oss® sections treated with Minocycline. A possible correlation of these centres with the basal skull bone, outside of our observation field, cannot be excluded. Conclusions and clinical implications: The osteoconductive and osteoinductive properties of bioactive glass particles could be confirmed within the limitations of the present study. Minocycline-HCl may be considered as a promising complementary treatment approach and may add some osteoinductive properties to DBBM. Further investigations into the volume of the newly generated bone are needed to refine the present results. [less ▲]

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See detailMulticomponent Radziszewski emulsion polymerization towards macroporous poly(ionic liquid)s catalysts
Stiernet, Pierre ULiege; Aqil, Abdelhafid ULiege; Zhu, Xiaomin et al

in ACS Macro Letters (2020), 9(1), 134-139

Interconnected macroporous imidazolium-based mono- liths are produced via the modified Radziszewski multicomponent reaction (MCR) applied to triamines under high internal phase emulsion (HIPE) conditions ... [more ▼]

Interconnected macroporous imidazolium-based mono- liths are produced via the modified Radziszewski multicomponent reaction (MCR) applied to triamines under high internal phase emulsion (HIPE) conditions. This straightforward one-pot synthesis combines the efficiency and versatility ofMCRs with the ease of implementation of the emulsion templating polymerization process. The characterization of the chemical structure and morphology of the resulting materials confirms the formation of the expected macroporous poly(ionic liquid)s (PILs) networks. The promising catalytic activity and recyclability of these porous PIL monoliths are illustrated for the transesterification reaction and the decarboxylation of caffeic acid. In these cases, almost complete conversion is reached while benefiting from the advantages associated with a heterogeneous catalyst. [less ▲]

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See detailADAM28: Another ambivalent protease in cancer
Hubeau, Céline ULiege; Rocks, Natacha ULiege; Cataldo, Didier ULiege

in Cancer Letters (2020), 494

Emergence of novel therapeutic options in a perspective of personalized therapy of cancer relies on the discovery of precise molecular mechanisms involved in the switch from a localized tumor to invasive ... [more ▼]

Emergence of novel therapeutic options in a perspective of personalized therapy of cancer relies on the discovery of precise molecular mechanisms involved in the switch from a localized tumor to invasive metastasis spread. Pro-tumor functions have been mostly ascribed to proteolytic enzymes from the metalloproteinase family including A Disintegrin And Metalloproteinases (ADAMs). Particularly, when expressed by cancer cells, ADAM28 protease supports cancer cell proliferation, survival and migration as well as metastatic progression. In sharp contrast, ADAM28 derived from the tumor microenvironment has shown to exert strong protective effects against deleterious metastasis dissemination. Indeed, depletion of host-derived ADAM28 (ADAM28 KO mice) accelerates colonization lung tissues, increases tumor foci implantation, and impairs T cell immune response. In this review, we outline specific ADAM28 functions when specifically expressed by carcinoma cells or by tumor microenvironment. Finally, we discuss about future research strategies that could be pursued to highlight new functions of this protease in cancer. © 2020 Elsevier B.V. [less ▲]

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See detailComparison of early-compartment correction equations for GFR measurements
DELANAYE, Pierre ULiege; Dubourg, Laurence; Flamant, Martin et al

in Kidney International Reports (2020), 5(7), 1079-1081

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See detailQuel futur pour les cellules-souches mésenchymateuses dans les affections ostéoarticulaires ?
HAUZEUR, Jean-Philippe ULiege

in Revue du Rhumatisme Monographies (2020)

Regenerative medicine using mesenchymal stem cells (MSC) is developped in several musculoskeletal diseases. The concentration of bone marrow or adipose tissue has been the most common therapeutic method ... [more ▼]

Regenerative medicine using mesenchymal stem cells (MSC) is developped in several musculoskeletal diseases. The concentration of bone marrow or adipose tissue has been the most common therapeutic method used. The large variability of the cell-productions, however, could be a limitation. Recent biological research concerning MSC has unearthed several new aspects. Firstly, a heterogeneity of the MSC was found following the tissue origin and/or the patient's. Then, the characterisation of MSC was improved by using new combinations of cellular membrane markers. Another important step was the discovery of the paracrine activity of MSC. The MSCs are able to produce a lot of growth factors and cytokines, a production of extra cellular vesicles like exosomes arising an intercellular signaling. MSCs were found to have not only a proliferation and differentiation performance to restore the damages of time, but also immunomodulation and anti-inflammation activities. The field of cell-based therapy with MSC is enlarged with newer and more promising methods than bone marrow concentrate. Expansion culture methods of MSC have been developped, as in vitro differentiation in osteoblasts and chondrocytes or cell manipulations by transfection to produce induced pluripotent stem cells or super MSCs able to produce more growth factors or cytokines, or to modify the membrane signaling for improving MSC homing. The translation of these biological developments in human therapy is the key for the MSC future. After pre-clinical tests to verify the safety, controlled trials are needed to define the true place of this regenerative medicine. © 2020 Société Française de Rhumatologie [less ▲]

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See detailHow to interpret an estimated glomerular filtration rate (eGFR) in 2020?
De Broe, M; DELANAYE, Pierre ULiege

in Kidney International (2020), 98(5), 1090-1092

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See detailLouer l'âne de Nebnéfer (O. Winand 1)
Polis, Stéphane ULiege; Winand, Jean ULiege

in Revue d'Egyptologie (2020), 70

Publication of a 20th Dynasty ostracon coming from Deir el-Medina that mentions the hire of a donkey belonging to Nebnefer (xii) son of Pentaweret (vii).

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See detailCarnet de santé: la myopathie atypique
Votion, Dominique ULiege

in Cheval Santé (2020), (130), 48-50

La myopathie atypique est une maladie saisonnière désormais bien présente en France et en Europe. Elle se caractérise par une destruction des muscles posturaux, respiratoires et du myocarde. Des études ... [more ▼]

La myopathie atypique est une maladie saisonnière désormais bien présente en France et en Europe. Elle se caractérise par une destruction des muscles posturaux, respiratoires et du myocarde. Des études récentes ont montré que la cause est une toxine présente dans les graines de certains arbres du genre « Acer » (érable), dont l’« Acer pseudoplatanus » ou érable sycomore. [less ▲]

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See detailPrélude : A la recherche de "secrets de fabrication" dans la médecine médiévale
Xhayet, Geneviève ULiege

in Sigila: Revue Transdisciplinaire Franco-Portugaise sur le Secret (2019), 44

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See detailL'enseignant-artisan
Defays, Jean-Marc ULiege

in Français dans le Monde: Revue Internationale et Francophone des Professeurs de Français (2019), (426), 29

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See detailMulti-matrices screening for untargeted volatilomics by GC×GC-TOFMS
Zanella, Delphine ULiege; HENKET, Monique ULiege; SCHLEICH, FLorence ULiege et al

in European Respiratory Journal. Supplement (2019), 54

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See detailFLA : Français Langue Amalgame
Defays, Jean-Marc ULiege

in Français dans le Monde: Revue Internationale et Francophone des Professeurs de Français (2019), (425), 29

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See detailÉvaluation clinique des états de conscience altérée: quelle échelle utiliser ?
Bonin, Estelle ULiege; Wolff, Audrey ULiege; Sanz, Leandro ULiege et al

in Lettre du Neurologue: le Courrier du Spécialiste (2019), XXIII(7), 253-254

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See detailPrecise co-registration of mass spectrometry imaging, histology, and laser microdissection-based omics
Dewez, Frédéric ULiege; Martin-Lorenzo, Marta; Herfs, Michael ULiege et al

in Analytical and Bioanalytical Chemistry (2019), 411

Mass spectrometry imaging (MSI) is an analytical technique for the unlabeled and multiplex imaging of molecules in biological tissue sections. It therefore enables the spatial and molecular annotation of ... [more ▼]

Mass spectrometry imaging (MSI) is an analytical technique for the unlabeled and multiplex imaging of molecules in biological tissue sections. It therefore enables the spatial and molecular annotation of tissues complementary to histology. It has already been shown that MSI can guide subsequent material isolation technologies such as laser microdissection (LMD) to enable a more in-depth molecular characterization of MSI-highlighted tissue regions. However, with MSI now reaching spatial resolutions at the single-cell scale, there is a need for a precise co-registration between MSI and the LMD. As proof-of-principle, MSI was performed on a breast cancer tissue and segmentation on the lipid data was performed to detect molecularly distinct segments within its tumor areas. After image processing of the segmentation results, the coordinates of the MSI detected segments were passed to the LMD system by three co-registration steps. The errors of each co-registration step were quantified and the total error was found to be less than 13 micrometers. With this link established, MSI data can now accurately guide LMD to excise MSI-defined regions of interest for subsequent extract-based analyses. In our example, the excised tissue material was then subjected to ultrasensitive microproteomics in order to determine predominant molecular mechanisms in each of the MSI highlighted intratumor segments. This work shows how the strengths of MSI, histology, and extract-based omics can be combined to enable a more comprehensive molecular characterization of in situ biological processes. [less ▲]

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See detailLa dyskinésie scapulaire chez le sportif
Forthomme, Bénédicte ULiege; Tooth, Camille ULiege; Croisier, Jean-Louis ULiege et al

in Axxon Exclusif (2019)

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See detailStratégies préventives et blessures sportives
Delvaux, François ULiege; Kaux, Jean-François ULiege; Forthomme, Bénédicte ULiege et al

in AXXON Exclusif (2019)

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See detailL'échelle géologique de Comblain-au-Pont et le grès eifelien rouge d'Esneux
Ek, Camille ULiege; Moulana, Meriem Lina ULiege

in Archéo-Contact : Bulletin du Cercle Archéo-Historique Le Vieil Esneux (2019), 54

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See detailIl n'est bon bec que de Paris
Defays, Jean-Marc ULiege

in Français dans le Monde: Revue Internationale et Francophone des Professeurs de Français (2019), (423), 29

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See detailBalancing Engagement and Neutrality in Technology Assessment
Delvenne, Pierre ULiege; Grunwald, Armin

in TATuP. Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis (2019), 28(1), 71-74

At the TA18 conference on “Technology Assessment and Normativity”, held in Vienna in June 2018, an equally spontaneous and memorable controversy arose between Armin Grunwald and Pierre Delvenne concerning ... [more ▼]

At the TA18 conference on “Technology Assessment and Normativity”, held in Vienna in June 2018, an equally spontaneous and memorable controversy arose between Armin Grunwald and Pierre Delvenne concerning the roles of neutrality and democracy in technology assessment (TA), its philosophical foundations, and TA’s obligation to be inclusive. How do TA’s obligation to democracy and its operational neutrality relate to each other, where do they interfere, and what are the practical consequences? And what does this imply for TA’s future? Should we shape TA today according to the ideals of a strong democracy that advocates value-oriented solutions while not shying away from conflicts? Or should we rather strive for a fundamental normative orientation toward democracy, which, however, for this very reason follows the neutrality principle in TA practice and does not favor certain pathways? As editors of TATuP’s special issue on normativity in technology assessment, our intention has been to make this debate accessible to a wider readership by confronting the two researchers once more with the core issues of their dispute. Interview by Linda Nierling (ITAS, KIT) and Helge Torgersen (ITA, Vienna). [less ▲]

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See detailEurooppalaiset periferiat postkoloniaalisessa kirjallisuudessa Liègen yliopisto, Belgia, 24.5.2018
Toivanen, Anna-Leena ULiege

in Avain: Kirjallisuudentutkimuksen aikakauslehti (2019), 16(1), 82-85

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See detailL'ubérisation de l'enseignement des langues
Defays, Jean-Marc ULiege

in Français dans le Monde: Revue Internationale et Francophone des Professeurs de Français (2019), (422), 27

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See detailDioxin testing will soon be five times more sensitive
Focant, Jean-François ULiege

in LabInsights (2019)

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See detail7th international symposium on hydraulic structures: a retrospect
Bung, Daniel; Tullis, Blake; Erpicum, Sébastien ULiege et al

in Hydrolink (2019), 2019(1), 26-27

Report on 7th Int. Symp. on hydraulic structures, Aachen, Germany, 14-18 May 2018

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See detailA comparative study of labeling algorithms within the branch-and-price framework for vehicle routing with time windows
Michelini, Stefano ULiege

in 4OR: A Quarterly Journal of Operations Research (2019), 17

Ph. D Thesis summary, see other reference on ORBI

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See detailPoly(ionic liquid)-derived N-doped carbons with hierarchical porosity for lithium- and sodium-ion batteries
Alkarmo, Walid ULiege; Ouhib, Farid ULiege; Aqil, Abdelhafid ULiege et al

in Macromolecular Rapid Communications (2019), 40(1), 1800545

The performance of lithium‐ and sodium‐ion batteries relies notably on the accessibility to carbon electrodes of controllable porous structure and chemical composition. This work reports a facile ... [more ▼]

The performance of lithium‐ and sodium‐ion batteries relies notably on the accessibility to carbon electrodes of controllable porous structure and chemical composition. This work reports a facile synthesis of well‐defined N‐doped porous carbons (NPCs) using a poly(ionic liquid) (PIL) as precursor, and graphene oxide (GO)‐stabilized poly(methyl methacrylate) (PMMA) nanoparticles as sacrificial template. The GO‐stabilized PMMA nanoparticles are first prepared and then decorated by a thin PIL coating before carbonization. The resulting NPCs reach a satisfactory specific surface area of up to 561 m2 g−1 and a hierarchically meso‐ and macroporous structure while keeping a nitrogen content of 2.6 wt%. Such NPCs deliver a high reversible charge/discharge capacity of 1013 mA h g−1 over 200 cycles at 0.4 A g−1 for lithium‐ion batteries, and show a good capacity of 204 mA h g−1 over 100 cycles at 0.1 A g−1 for sodium‐ion batteries. [less ▲]

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See detailPaludisme : Un nouveau candidat au traitement
Degotte, Gilles ULiege

in FNRS News (2019)

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See detailAtlantique littéraire et études francophones
Provenzano, François ULiege

in Cadernos de Literatura Comparada (2019)

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See detailUgi three-component polymerization toward poly(α-amino amide)s
Stiernet, Pierre ULiege; Lecomte, Philippe ULiege; De Winter, Julien et al

in ACS Macro Letters (2019), 8

Due to their great modularity, ease of implementation, and atom economy, multicomponent reactions (MCRs) are becoming increasingly popular macromolecular engineering tools. In this context, MCRs suitable ... [more ▼]

Due to their great modularity, ease of implementation, and atom economy, multicomponent reactions (MCRs) are becoming increasingly popular macromolecular engineering tools. In this context, MCRs suitable in polymer synthesis are eagerly searched for. This work demonstrates the potential of the Ugi-three component reaction (Ugi-3CR) for the design of polymers and, in particular, of poly(α-amino amide)s. A series of polymers containing amino and amido groups within their backbone were obtained through a one-pot process by reacting aliphatic or aromatic diamines, diisocyanides, and aldehydes. The impact of temperature, concentration, catalyst loading, and substrates on polymerization efficiency is discussed. A preliminary study on the thermal properties and the solution behavior of these poly(α-amino amide)s was carried out. An aliphatic-rich derivative notably showed some pH-responsiveness in water via protonation−deprotonation of its amino groups. [less ▲]

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See detailVitamin D Supplementation in France in patients with or at risk for osteoporosis: Recent data and new practices
Souberbielle, Jean-Claude; Cormier, Catherine; Cavalier, Etienne ULiege et al

in Joint Bone Spine (2019)

With intermittent vitamin D supplementation, serum 25-hydroxyvitamin D (25OHD)levels may remain stable only if the dosing interval is shorter than 3 months, the ideal perhaps being about 1 month. Recent ... [more ▼]

With intermittent vitamin D supplementation, serum 25-hydroxyvitamin D (25OHD)levels may remain stable only if the dosing interval is shorter than 3 months, the ideal perhaps being about 1 month. Recent data support moderate daily vitamin D doses instead of high intermittent doses, notably in elderly patients prone to falls. The level of evidence is low, however, with no head-to-head comparisons of clinical outcomes such as fractures and falls in groups given identical dosages daily versus intermittently. A challenge to daily vitamin D supplementation in France is the absence of a suitable pharmaceutical formulation. In addition, daily dosing carries a high risk of poor adherence. Until suitable vitamin D3 formulations such as tablets or soft capsules each containing 1000 or 1500 IU become available, we suggest intermittent supplementation according to 2011 GRIO guidelines. Among the available dosages, the lowest should be preferred, with the shortest possible interval, e.g., 50,000 IU monthly rather than 100,000 every two months. © 2019 Société française de rhumatologie [less ▲]

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See detailGermigny-des-Prés, Place du Bourg
Van Wersch, Line ULiege; Henrion, Fabrice

in Bilan scientifique de la région Centre-Val de Loire (2019)

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See detailJ'aime, un peu, beaucoup, pasionnément... l'accord du participe passé
Defays, Jean-Marc ULiege

in Français dans le Monde: Revue Internationale et Francophone des Professeurs de Français (2018), (420), 29

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See detailIntroducing a Dataset of Guitar Amplifier Sounds for Nonlinear Emulation Benchmarking
Schmitz, Thomas ULiege; Embrechts, Jean-Jacques ULiege

in AES E-Library (2018)

Recent progresses made in the nonlinear system identification field have improved the ability to emulate nonlinear audio systems such as tube guitar amplifiers. As a straightforward comparison of ... [more ▼]

Recent progresses made in the nonlinear system identification field have improved the ability to emulate nonlinear audio systems such as tube guitar amplifiers. As a straightforward comparison of different models cannot always be made, we propose a new reference dataset enabling to highlight the strengths and weaknesses of different nonlinear modeling methods. Our dataset gathers five different styles of guitar sounds passing through different guitar amplifiers with 10 steps of their gain parameter (i.e., the distortion level of the amplifier). Moreover, a Matlab function is also provided to obtain the desired input/output sounds in a matrix form. [less ▲]

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See detailImplementing an Integrated Care System for Chronic Patients in Belgium: a Co-creation Process
De Winter, Mélanie ULiege

in International Journal of Integrated Care (2018)

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See detailCronaca de : Les astrologues dans l’entourage des empereurs romains, des Julio-Claudiens aux Sévères. Colloque international organisé à l’occasion du 150ème anniversaire de la naissance de Franz Cumont: Liège, Université, Salle Lumière, 20-21 juin 2018
Fantoli, Margherita ULiege

in Bollettino di Studi Latini (2018), XLVIII(2),

Bref résumé du colloque "Les astrologues dans l’entourage des empereurs romains, des Julio-Claudiens aux Sévères. Colloque international organisé à l’occasion du 150ème anniversaire de la naissance de ... [more ▼]

Bref résumé du colloque "Les astrologues dans l’entourage des empereurs romains, des Julio-Claudiens aux Sévères. Colloque international organisé à l’occasion du 150ème anniversaire de la naissance de Franz Cumont: Liège, Université, Salle Lumière, 20-21 juin 2018" [less ▲]

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See detailCooperation in the Field of Rare Diseases: A Social Science Perspective
Duysens, Fanny ULiege

in Orphanet Journal of Rare Diseases (2018), 13(Suppl 2), 14

As unanimously claimed within the rare disease community, cooperation between all stakeholders is a necessity in order to tackle these diseases and improve the difficult situations faced by patients and ... [more ▼]

As unanimously claimed within the rare disease community, cooperation between all stakeholders is a necessity in order to tackle these diseases and improve the difficult situations faced by patients and families. Public authorities, health professionals, scientists, industrials, or obviously patients and relatives' associations, have an active part to play in the collective projects that are currently being developed worldwide. However, putting cooperation into practice does not always go unhindered. Drawing on a qualitative research in social sciences, this poster presented some drivers and effects of cooperation in the field of rare diseases in Belgium and, more generally, in Europe. It highlighted some meaningful points of agreement and tension such as the degree of adequacy between international guidelines and national constraints, the confrontation between professional and experiential points of view, or the multiple meanings and uses of the "rare diseases" category. To conclude, the poster stated the value of multidisciplinary perspectives and mutual exchanges between social scientists and stakeholders, for the joint understanding of, and cooperation in, the lively field of rare diseases. [less ▲]

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See detailIntegration of redox-active catechol pendants into poly(ionic liquid) for the design of high-performance lithium-ion battery cathodes
Patil, Nagaraj; Aqil, Mohamed ULiege; Ouhib, Farid ULiege et al

in Chemistry of Materials (2018), 30(17), 5831-5835

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See detailPolyglotte en un clic!
Defays, Jean-Marc ULiege

in Français dans le Monde: Revue Internationale et Francophone des Professeurs de Français (2018), (419), 27

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See detailOn-field Electro-ejaculation of Wild Prezwalski Horses: Results and Perspectives
Rigaux, Goulven; Parrilla Hernandez, Sonia ULiege; Egyptien, Sophie ULiege et al

in Journal of Equine Veterinary Science (2018), 66

hus, semen collected from wild horses by electro-ejaculation performed under anaesthesia could be shipped after large dilution to the lab and eventually used for AI programs, if CASA results show ... [more ▼]

hus, semen collected from wild horses by electro-ejaculation performed under anaesthesia could be shipped after large dilution to the lab and eventually used for AI programs, if CASA results show sufficient motility. [less ▲]

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See detailThe Sustainable Livelihoods Approach and the Capitals Framework Analysis at Household level: case study in coastal sandy zone in Thua Thien Hue
Dao Duy Minh, ULiege; Hao, Nguyen Dang; Lebailly, Philippe ULiege

in PET 2018 - Hue (2018)

Located in the central region of Vietnam, Thua Thien Hue has been playing important roles in the strategy of economic development in Vietnam (Ministry, 2014). Basing on the Sustainable Livelihood ... [more ▼]

Located in the central region of Vietnam, Thua Thien Hue has been playing important roles in the strategy of economic development in Vietnam (Ministry, 2014). Basing on the Sustainable Livelihood Framework Analysis (SLFA) (DFID, 2000), this study aimed to assess the evolution of 5 capitals in SLFA namely Human, Physical, Financial, Natural and Social capital at household level in coastal sandy zone in Thua Thien Hue during the period from 2007 to 2017. In addition, the primary results will be the foundation to implement some implications for next studies. Using baseline data from Hao’s study in 2009, this study conducted 110 households with the same questionnaire template at 4 districts in Thua Thien Hue province. The results showed the sensitive changes in livelihood’s capitals at the household level: i. the household size reduced significantly from 5.9 to 4.6 members; ii. The significant improvement in living condition, households spent more money on buying modern facilities; many households invested new modern machine that could help to reduce the time and save the cost in livelihood activities. iii. the percentage of households accessing credits has significantly decreased; v. Women Union (WU) and Farmer Association (FA) are the most popular social networks that involved the most of the farmers in the study sites. [less ▲]

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See detailEnseigner, c'est s'engager!
Defays, Jean-Marc ULiege

in Français dans le Monde: Revue Internationale et Francophone des Professeurs de Français (2018), (417), 29

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See detailTetrabutyl ammonium salts: cheap catalysts for the facile and selective synthesis of a-alkylidene cyclic carbonates from CO2 and alkynol
Méreau, Raphaël; Grignard, Bruno ULiege; Boyaval, Amélie ULiege et al

in ChemCatChem (2018), 10(5), 956-960

n-tetrabutyl ammonium organic salts are used for the first time as catalysts for the coupling of CO2 with 2-methyl-3-butyn-2-ol to form α-methylene cyclic carbonate. The final yields could reach 98% in ... [more ▼]

n-tetrabutyl ammonium organic salts are used for the first time as catalysts for the coupling of CO2 with 2-methyl-3-butyn-2-ol to form α-methylene cyclic carbonate. The final yields could reach 98% in less than 10 hours at 353K and 3MPa under solvent free conditions. A particular synergistic effect between the cation and the anion of the organocatalyst is demonstrated through catalyst screening. Online kinetic studies by ATR-IR spectroscopy correlated to DFT calculations reveal a compelling evolution of the solvation of the catalyst during the reaction that provide an understanding of the underlying reason for the observed unique kinetics and selectivity. Such in-depth fundamental mechanistic and kinetic studies enable determining and comprehending the key parameters favouring the design of novel highly active and selective catalysts for the valorisation [less ▲]

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See detailOrganometallic mediated radical polymerization of vinylidene fluoride
Banerjee, Sanjib; Ladmiral, Vincent; Debuigne, Antoine ULiege et al

in Angewandte Chemie International Edition (2018), 57(11), 2934-2937

An unprecedented level of control for the radical polymerization of vinylidene fluoride (VDF), yielding well-defined PVDF (up to 14,500 g/mol) with low dispersity (≤1.32), was achieved using ... [more ▼]

An unprecedented level of control for the radical polymerization of vinylidene fluoride (VDF), yielding well-defined PVDF (up to 14,500 g/mol) with low dispersity (≤1.32), was achieved using organometallic mediated radical polymerization (OMRP) with an organocobalt compound as initiator. The high chain-end fidelity was demonstrated by the synthesis of PVDF- and PVAc-containing di-and tri-block copolymers. DFT calculations rationalize the efficient reactivation of both head and tail chain end dormant species. [less ▲]

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See detailL'orthographe, vaut mieux en rire!
Defays, Jean-Marc ULiege

in Français dans le Monde: Revue Internationale et Francophone des Professeurs de Français (2018), (416), 29

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See detailEthylene/vinyl acetate-based macrocycles via organometallic-mediated radical polymerization and CuAAC ‘click’ reaction
Demarteau, Jérémy ULiege; De Winter, Julien; Detrembleur, Christophe ULiege et al

in Polymer Chemistry (2018), 9(3), 273-278

Recent advances in organometallic-mediated radical polymerization led to unique α,ω-difunctional poly(vinyl acetate) (PVAc) and ethylene/vinyl acetate copolymers (EVA). A copper- catalyzed Huisgen dipolar ... [more ▼]

Recent advances in organometallic-mediated radical polymerization led to unique α,ω-difunctional poly(vinyl acetate) (PVAc) and ethylene/vinyl acetate copolymers (EVA). A copper- catalyzed Huisgen dipolar cycloaddition ring-closure reaction was applied to these difunctional precursors paving the way to unprecedented PVAc and/or EVA macrocycles, and to their PVOH- and EVOH-counterparts after hydrolysis. [less ▲]

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See detailAquaCrop and ICT to improve irrigation efficiencies
Wellens, Joost ULiege; Wahbi, Amar; Tychon, Bernard ULiege et al

in FAO /IAEA Soils Newsletter (2018), 40(2),

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See detailFeeding world population amidst depleting phosphate reserves: The role of biotechnological interventions
Stanislaus, Antony Ceasar ULiege

in Open Biotechnology Journal (2018), 12

Phosphorus (P) is an important macronutrient affecting the growth and yield of all crop plants. Plants absorb P from the soil solution as inorganic phosphate (Pi). More than 70% of the arable land is ... [more ▼]

Phosphorus (P) is an important macronutrient affecting the growth and yield of all crop plants. Plants absorb P from the soil solution as inorganic phosphate (Pi). More than 70% of the arable land is deficient of Pi which demands the supply of an external source of synthetic P fertilizers to improve the yields. The P fertilizers are manufactured from non-renewable rock phosphate reserves which are expected to be exhausted within the next 100-200 years. This poses a great threat to food security since it is very difficult to meet the food production caused by increasing world population without the supply of an adequate P fertilizer. Several efforts have been made in the past decade to understand the mechanism of Pi uptake and its redistribution in plants. In this mini-review, we discuss the details on possible strategies to combat the crisis caused by loss of phosphate rock reserves and to improve the crop yield without much dependency on external P fertilizer. Approaches such as application of functional genomics studies to manipulate the expression levels of key transcription factors and genes involved in low Pi stress tolerance, molecular marker-assisted breeding to develop new varieties with improved yields under Pi-deficient soils and to recapture the Pi released in wastewaters for recycling back to the farm lands, will help improve the crop production without depending much on non-renewable P fertilizers and will also aid for the sustainable food production. © 2018 S. Antony Ceasar. [less ▲]

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See detailA Preliminary Study Into Meniscal Innervation in 2 Horses With Different Degrees of Chondropathy in the Femorotibial Joint
Nemery, Elodie ULiege; Gabriel, Annick ULiege; Moyse, Evelyne ULiege et al

in Journal of Equine Veterinary Science (2018)

Osteoarthritis is a painful degenerative disease, sometimes responsible for the premature ending of the careers of sporting horses. In humans, meniscal neurogenesis has been suggested to contribute to ... [more ▼]

Osteoarthritis is a painful degenerative disease, sometimes responsible for the premature ending of the careers of sporting horses. In humans, meniscal neurogenesis has been suggested to contribute to pain in osteoarthritis. To the best of our knowledge, no study on this subject has been performed in equine species. The aim of this report was to compare the density of the nociceptive and sympathetic nerves in the menisci of two 11- and 13-year-old mares, one presenting a “low-chondropathy grade” in its stifle and the other a “high-chondropathy grade”. The cranial horns of the medial menisci, a commonly reported site of equine meniscal injuries, were harvested after a maximum of 48 hours postmortem. A macroscopic and microscopic grading system was established using a modified Pauli score. Nociceptive fibers were highlighted by immunohistochemical staining with an antibody against Substance P (SP) and postganglionic sympathetic fibers with an antibody against tyrosine hydroxylase (TH). Descriptive statistics were calculated, and a nonparametric statistical test was used to analyze the data. The meniscus from the “high-chondropathy horse (HCH)” showed a higher density and frequency of postganglionic sympathetic nerves compared with the meniscus of the “low-chondropathy horse (LCH)”. No difference was observed regarding nociceptive nerves. This report shows possible meniscal sympathetic efferent-mediated pain in a “highly chondropathic horse”. Although these results cannot be extended to the equine population as a whole because of the small sample size, they are nevertheless interesting as they provide new information regarding the possible etiology of the pain in equine stifle osteoarthritis. [less ▲]

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See detailLumipulse W-PTH 3rd generation assay: reference values in healthy population and classification of secondary hyperparathyroidism in CKD
CAVALIER, Etienne ULiege; Salsé, Margot; Dupuy, Anne-Marie et al

in Nephrology, Dialysis and Transplantation (2018)

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See detailÀ propos de Voltaire : une icône au prisme du tragique
Daubercies, Laurence ULiege

in Revue Voltaire (2018), 18

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See detailThe Rise of Cotton Genomics.
Syed-Shan-e-Ali, Zaïdi ULiege; Mansoor, Shahid; Paterson, Andrew

in Trends in Plant Science (2018), 23(11), 953-955

Cotton is the most important fiber crop, but its polyploid genome is complex and difficult to improve. Recent advances in obtaining high-quality genome sequences of cultivated tetraploid and diploid ... [more ▼]

Cotton is the most important fiber crop, but its polyploid genome is complex and difficult to improve. Recent advances in obtaining high-quality genome sequences of cultivated tetraploid and diploid cotton species may now overcome this hurdle, as well as provide new insights on important fiber quality and disease resistance genes. [less ▲]

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See detailThe sweet smell of success
Focant, Jean-François ULiege

in Analytical Scientist (2018), 1118

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See detailP054 - Evaluation of ground reaction forces by inverse dynamics analysis
Van Hulle, Romain ULiege; Schwartz, Cédric ULiege; Denoël, Vincent ULiege et al

in Gait and Posture (2018), 65

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See detailKrijgt u binnenkort een robot als confrater?
Berrendorf, Alyson ULiege

in Blog UR Cité (2018)

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See detailReport on the political participation of mobile EU citizens: Romania
Vintila, Cristina-Daniela ULiege; Soare, Sorina

in Global Citizenship Observatory GLOBALCIT (2018), 10

Since Romania’s accession to the European Union, resident EU citizens enjoy the right to vote in and stand for local elections and European Parliament (EP) elections held in Romania. Due to the fact that ... [more ▼]

Since Romania’s accession to the European Union, resident EU citizens enjoy the right to vote in and stand for local elections and European Parliament (EP) elections held in Romania. Due to the fact that non-resident nationals vastly outnumber EU citizens residing in Romania, the enfranchisement of Romanians abroad is, however, a much more salient issue in Romania. Non-resident nationals may vote in national and EP elections, but cannot stand as candidates if they are registered with the domicile abroad. The turnout of non-citizen resident and non-resident citizens in elections held in Romania is overall quite low. Possible facilitators would be to simplify the voting and registration procedure and to introduce more awareness raising campaigns specifically targeting resident EU citizens and Romanians abroad. [less ▲]

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See detailReport on the political participation of mobile EU citizens: Belgium
Vintila, Cristina-Daniela ULiege; Lafleur, Jean-Michel ULiege; Nikolic, Louise

in Global Citizenship Observatory (2018), 13

In Belgium, EU citizens and third-country nationals have the right to vote in local elections. Third-country nationals only gain this right after five years of continuous residence in Belgium. EU citizens ... [more ▼]

In Belgium, EU citizens and third-country nationals have the right to vote in local elections. Third-country nationals only gain this right after five years of continuous residence in Belgium. EU citizens also enjoy passive electoral rights in local elections. Furthermore, EU citizens have the right to vote in and stand for the European Parliament (EP) elections held in Belgium. The electoral rights for nonresident Belgian citizens are more restrictive. Non-resident citizens have the right to vote, but not to stand for national legislative elections. Belgian citizens also have the right to vote for EP elections, whether they reside in another EU Member State or a third country, but only those residing in other EU Member States can stand as candidates for these elections. Once registered, all voters are obliged to vote in Belgium. Despite the dissemination efforts made by different institutions and civil society organizations for past elections in Belgium, a key difficulty that voters still face is the lack of information about the Belgian registration procedures and the political process more generally. Possible facilitators to encourage the political participation of non-citizen residents would be to formalise information dissemination strategies and communicate with new residents in different languages. [less ▲]

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See detailParaneoplastic secretion in parathyroid carcinoma: serum hCG as a tumor marker
VALDES SOCIN, Hernan Gonzalo ULiege; BETEA, Daniela ULiege; Daly, Adrian ULiege et al

in Acta Clinica Belgica (2017), 72(2), 5

Introduction Parathyroid carcinoma (PCa) is a rare presentation of primary hyperparathyroidism (PHPT), accounting for less than 1 % of cases. Differentiating parathyroid cancer from adenoma is clinically ... [more ▼]

Introduction Parathyroid carcinoma (PCa) is a rare presentation of primary hyperparathyroidism (PHPT), accounting for less than 1 % of cases. Differentiating parathyroid cancer from adenoma is clinically challenging. Rubin et al (2008) et al. suggested that urinary hCG might be a marker of disease progression in PCa. In this study, we aimed to investigate whether the hCG+β kit from Roche Diagnostics could distinguish PCa patients from PHPT. Material and methods We studied a series of 8 patients suffering from advanced PCa, referred to the CHU de Liege. A control group of 20 PHPT patients was used as comparative. hCG+β kit on Cobas (Roche Diagnostics) uses 2 monoclonal antibodies that recognize holo-hCG, nicked hCG, β-core fragment and free β-subunit. Limits of hCG detection and quantification are <0.1 and <0.6 mUI/mL. In non pregnant and postmenopausal women and in men, hCG (p95) is <1 (5.3), <7 mUI/mL (8.3) and <2 (2.6) mUI/mL, respectively. Results. The 8 PCa patients (3 women) presented high serum hCG values at: 1.29, 3.46, 5.7, 24.2, 31.2, 34.1, 36.5 and 164 mUI/mL. Values of 1.29 and 3.46 were obtained in 2 postmenopausal women. The lowest value was presented by the only still alive patient. There was a significant correlation (r=0.786; ρ <0.05) between hCG and PTH and a borderline correlation (r=0.750; ρ =0.05) between hCG and calcium concentrations. All PHP patients presented undetectable hCG values. Conclusions These results suggest that serum hCG might have the potential to discriminate between parathyroid adenomas and carcinomas, with a sensibility of 75% (6/8) and a specificity of 100% (0/20). The only patient still alive presented the lowest hCG values. If hCG could be predictive of PCa survival needs to be studied in a larger series of patients. [less ▲]

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See detailThe LNQ25 and ELN PVT Metrics Exhibit a Good Sensitivity to Sleep Deprivation and are Independent from the Subject
Latour, Philippe ULiege; Van Droogenbroeck, Marc ULiege

in Sleep Medicine (2017), 40

Introduction Performance of people undergoing critical tasks (like driving) may be impaired completely by the lowering of their vigilance level, due to sleep deprivation for instance. This reduction of ... [more ▼]

Introduction Performance of people undergoing critical tasks (like driving) may be impaired completely by the lowering of their vigilance level, due to sleep deprivation for instance. This reduction of performance may be measured by metrics computed from the reaction times (RT) recorded during a 10min Psychomotor Vigilance Test (PVT). Here, we analyze and compare the sensitivity to sleep deprivation and the subject dependent variability of the PVT metrics performance, with a special emphasis on the time interval sizes. Materials and Methods Individuals (22 volunteers; 11 males, 11 females, mean 22.2y., range 19-34 years) follow an uninterrupted 28h sleep deprivation standard PVT protocol during which they achieved two groups of three PVT sessions (in different conditions). The first PVT of each group is in Non-SDP condition (9h30 and 10h30 Day 1) and the second and third PVT of each group are in SDP condition (2h30, 3h30, 10h30 and 11h30 day 2). The subjects fill a sleep journal during the week before the experiment. We checked that they had a normal sleep-wake cycle with no sleep deprivation, jet-lag or shift work and no medication. During the PVT of the first group, the subjects were wearing the glasses of the Phasya’s Drowsimeter. We compute the usual PVT metrics; meanRT, meanRS (Reaction Speed) and LN500 (500ms lapses number). We also compute LNQ25 (adaptive lapses number computed with a subject dependent threshold) and ELN (Expected Lapse Number, computed from a subject-dependent estimation of the lapse probability). Results We use the “Effect Size” (ES, ratio of the mean by the standard deviation of the difference of metrics in the SDP and Non-SDP conditions) to assess the sensitivity to sleep deprivation. For the 10min (resp. 1min, 3min) interval, the ES of LNQ25 and ELN are respectively 1.38 (resp. 0.95, 1.22) and 1.35 (resp. 0.85, 1.14), the ES of meanRS, meanRT and LN500 are 1.23 (resp. 0.91, 1.09), 0.81 (resp. 0.54, 0.68) and 0.85 (resp. 0.63, 0.77). We classify the intervals on which metrics are computed as SDP or non-SDP. We use a fixed threshold for the metrics, independent of the subject. In the ROC curves, the TPR (for a FPR of 10%) assesses the quality of the classification, and then also the subject independence. For the 10min (resp. 1min, 3min) interval, the TPR of LNQ25 and ELN are respectively 0.86 (resp. 0.56, 0.75) and 0.83 (resp. 0.58, 0.75), the TPR of meanRS, meanRT and LN500 are 0.42 (resp. 0.38, 0.41), 0.40 (resp. 0.39, 0.40) and 0.42 (resp. 0.24, 0.30). Conclusions We demonstrate that LNQ25 and ELN enable a quite good classification of the SDP condition for time intervals greater than or equal to 3min, independently of the subject. On the other hand, these metrics provide also a good sensitivity to sleep deprivation. They outperform the usual metrics for both criteria. For time intervals below 3min, the performances degrade first progressively and then much more quickly below 1min. [less ▲]

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See detailUnique alternating peptide-peptoid copolymers from dipeptides via Ugi reaction in water
Al Samad, Assala ULiege; De Winter, Julien; Gergaux, Pascal et al

in Chemical Communications (2017), 53(90), 12240-12243

Herein, we developed a strainghtforward aqueous synthesis of unprecedented alternating peptide-peptoid copolymers via Ugi four-component reaction applied to dipeptides. Functional peptide-peptoid ... [more ▼]

Herein, we developed a strainghtforward aqueous synthesis of unprecedented alternating peptide-peptoid copolymers via Ugi four-component reaction applied to dipeptides. Functional peptide-peptoid copolymers as well as block copolymers were produced in a single step in the presence of acrylic acid and carboxylic acid-terminated poly(ethylene glycol). The thermoresponsiveness of these polymers is highlighted [less ▲]

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See detailEnhanced stabilization of water-scCO2 interface by block-like spontaneous gradient copolymers
Liu, Xuan; Wang, Mingxi; Harrisson, Simon et al

in ACS Sustainable Chemistry and Engineering (2017), 5(11), 9645-9650

There is an increasing interest in the specific physicochemical properties of gradient copolymers at interfaces. In this work, the phase behavior and interfacial properties of amphiphilic gradient ... [more ▼]

There is an increasing interest in the specific physicochemical properties of gradient copolymers at interfaces. In this work, the phase behavior and interfacial properties of amphiphilic gradient copolymers at the water/CO2 interface are explored and compared to that of diblock copolymer counterparts. It is observed that spontaneous amphiphilic block-like gradient copolymers made of N,N-dimethylacrylamide, vinyl pivalate, and vinyl acetate exhibit slightly lower cloud point pressures in supercritical carbon dioxide (scCO2) than the corresponding diblock copolymers. Much more pronounced differences are established at the water/scCO2 interface, with larger critical aggregation concentration (CAC), much faster adsorption kinetics and equilibration, and lower surface tension for gradient copolymers. RAFT/MADIX polymerization allows the control of molar mass, composition, and microstructure of the copolymers of the study. These findings shed light on how microstructural control in amphiphilic copolymers can give access to a new range of macromolecular emulsifiers for CO2 media with improved properties. [less ▲]

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See detailUne didactique des langues écologique?
Defays, Jean-Marc ULiege

in Français dans le Monde: Revue Internationale et Francophone des Professeurs de Français (2017), (414), 25

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See detailEffect of whole body cryotherapy interventions on health-related quality of life in fibromyalgia patients: A randomized controlled trial
Vitenet, Mathilde; Tubez, François ULiege; Marreiro, Anthony et al

in Complementary Therapies in Medicine (2017), 36

Introduction: Although fibromyalgia syndrome (SFM) affects 2–4 percent of adults, research has not identified a preferred therapeutic option for patients worldwide yet. Based on recent findings, it can be ... [more ▼]

Introduction: Although fibromyalgia syndrome (SFM) affects 2–4 percent of adults, research has not identified a preferred therapeutic option for patients worldwide yet. Based on recent findings, it can be expected that whole body cryotherapy can improve health-reported quality of life by alleviating the symptoms of musculoskeletal pain and fatigue. Objective: Our aim was to determine whether whole body cryotherapy only can result in improved perceived health and quality of life in fibromyalgia patients. Methods: 24 patients with fibromyalgia diagnosis were randomized into 2 groups (n= 11 in the whole body cryotherapy group, n=13 in the control group). In the whole body cryotherapy group, 10 sessions of whole body cryotherapy were performed (in addition to usual care) in a standard cryotherapy room over a duration of 8 days. Subjects in the control group did not change anything in their everyday activities. Quality of life was assessed just before and one month after treatment. Results: Compared with the control group, patients in the whole body cryotherapy group reported significantly improved for health-reported quality of life. These effects lasted for at least one month following intervention. Conclusion: Based on these findings, whole body cryotherapy can be recommended as an effective clinically adjuvant approach in the improvement of health-related quality of life in fibromyalgia patients. [less ▲]

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See detailDesign and Management of Freight Transport Networks: Intermodal Transport and Externalities
Mostert, Martine ULiege

in 4OR: A Quarterly Journal of Operations Research (2017)

Ph.D. thesis summary. Please refer to http://orbi.ulg.ac.be/handle/2268/211640 for the complete thesis.

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See detailBioinspired redox-active catechol-bearing polymers as ultra-robust organic cathodes for lithium storage
Patil, Nagaraj ULiege; Aqil, Abdelhafid ULiege; Ouhib, Farid ULiege et al

in Advanced Materials (2017), 29(40), 1703373

Redox-active catechols are bioinspired precursors for ortho-quinones that are characterized by higher discharge potentials than para-quinones, the latter being extensively used as organic cathode ... [more ▼]

Redox-active catechols are bioinspired precursors for ortho-quinones that are characterized by higher discharge potentials than para-quinones, the latter being extensively used as organic cathode materials for lithium ion batteries (LIBs). Here, this study demonstrates that the rational molecular design of copolymers bearing catechol- and Li+ ion-conducting anionic pendants endow redox-active polymers (RAPs) with ultrarobust electrochemical energy storage features when combined to carbon nanotubes as a flexible, binder-, and metal current collector-free buckypaper electrode. The importance of the structure and functionality of the RAPs on the battery performances in LIBs is discussed. The structure-optimized RAPs can store high-capacities of 360 mA h g−1 at 5C and 320 mA h g−1 at 30C in LIBs. The high ion and electron mobilities within the buckypaper also enable to register 96 mA h g−1 (24% capacity retention) at an extreme C-rate of 600C (6 s for total discharge). Moreover, excellent cyclability is noted with a capacity retention of 98% over 3400 cycles at 30C. The high capacity, superior active-material utilization, ultralong cyclability, and excellent rate performances of RAPs-based electrode clearly rival most of the state-of-the-art Li+ ion organic cathodes, and opens up new horizons for large-scalable fabrication of electrode materials for ultrarobust Li storage. [less ▲]

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See detailBeyond Consensus? A Reply to Alan Irwin
Van Bouwel, Jeroen; Van Oudheusden, Michiel ULiege

in Social Epistemology Review & Reply Collective (2017)

In this short reply to Alan Irwin, we zoom in on the three main issues he raises: 1. How to understand consensus? 2. Why are so many public participation activities consensus driven? 3. Should we not ... [more ▼]

In this short reply to Alan Irwin, we zoom in on the three main issues he raises: 1. How to understand consensus? 2. Why are so many public participation activities consensus driven? 3. Should we not value the art of closure? We also use this opportunity to highlight and further develop some of the ideas presented in our research paper "Participation Beyond Consensus? Technology Assessments, Consensus Conferences and Democratic Modulation." [less ▲]

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See detailCOMPORTEMENT CLINIQUE ET VIEILLISSEMENT HYDRIQUE DES COURONNES MONOLITHIQUES EN ZIRCONE YTTRIUM 1
KOENIG, Vinciane ULiege; WULFMAN, Claudine; Mainjot, Amélie ULiege

in Biomatériaux Cliniques (2017), 2

La zircone a été mise sur le marché pour l’élaboration d’infrastructures prothétiques dentaires au début des années 2000, grâce à l’avènement des procédés de conception et fabrication assistées par ... [more ▼]

La zircone a été mise sur le marché pour l’élaboration d’infrastructures prothétiques dentaires au début des années 2000, grâce à l’avènement des procédés de conception et fabrication assistées par ordinateur (CFAO). Ses bonnes propriétés de biocompatibilité, de résistance mécanique, ainsi que ses propriétés optiques en font une bonne alternative au métal [1]. Depuis quelques années, l’utilisation de la zircone augmente [2], parfois au détriment d’autres matériaux céramiques, notamment en raison de sa résistance élevée qui permet de réaliser des bridges de plusieurs éléments [3]. Les couronnes et bridges sont traditionnellement des structures bicouches composées d’une infrastructure, qui constitue le renfort mécanique de la restauration, et d’une couche de céramique d’émaillage, plus fragile, qui en assure le rendu esthétique. L’écaillage de la céramique cosmétique est la principale cause d’échec des restaurations en zircone émaillée. Jusqu’à présent, l’incidence de cette complication est réputée être plus élevée qu’avec les restaurations céramo-métalliques. En effet, les taux rapportés dans la littérature tournent autour de 13 %, alors que ceux de la céramique émaillée sur métal avoisinent seulement 3 % à 5 ans [4-6]. Pour remédier à ce problème, les fabricants commercialisent depuis quelques années des couronnes monolithiques, c’est-àdire entièrement en zircone, simplement maquillées en surface avec une glaçure [less ▲]

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