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See detailThe role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves: from field observations to toxicokinetics.
Valgaeren, Bonnie; Theron, Leonard; Croubels, Siska et al

in Archives of Toxicology (in press)

A clinical case in Belgium demonstrated that feeding a feed concentrate containing considerable levels of deoxynivalenol (DON, 1.13 mg/kg feed) induced severe liver failure in 2- to 3-month-old beef ... [more ▼]

A clinical case in Belgium demonstrated that feeding a feed concentrate containing considerable levels of deoxynivalenol (DON, 1.13 mg/kg feed) induced severe liver failure in 2- to 3-month-old beef calves. Symptoms disappeared by replacing the highly contaminated corn and by stimulating ruminal development via roughage administration. A multi-mycotoxin contamination was demonstrated in feed samples collected at 15 different veal farms in Belgium. DON was most prevalent, contaminating 80% of the roughage samples (mixed straw and maize silage; average concentration in positives: 637 +/- 621 microg/kg, max. 1818 microg/kg), and all feed concentrate samples (411 +/- 156 microg/kg, max. 693 microg/kg). In order to evaluate the impact of roughage provision and its associated ruminal development on the gastro-intestinal absorption and biodegradation of DON and its acetylated derivatives (3- and 15-ADON) in calves, a toxicokinetic study was performed with two ruminating and two non-ruminating male calves. Animals received in succession a bolus of DON (120 microg/kg bodyweight (BW)), 15-ADON (50 microg/kg BW), and 3-ADON (25 microg/kg) by intravenous (IV) injection or per os (PO) in a cross-over design. The absolute oral bioavailability of DON was much higher in non-ruminating calves (50.7 +/- 33.0%) compared to ruminating calves (4.1 +/- 4.5%). Immediately following exposure, 3- and 15-ADON were hydrolysed to DON in ruminating calves. DON and its acetylated metabolites were mainly metabolized to DON-3-glucuronide, however, also small amounts of DON-15-glucuronide were detected in urine. DON degradation to deepoxy-DON (DOM-1) was only observed to a relevant extent in ruminating calves. Consequently, toxicity of DON in calves is closely related to roughage provision and the associated stage of ruminal development. [less ▲]

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See detailEquivalence des hypothèses et relativité du mouvement dans la Dynamica
Bouquiaux, Laurence ULiege

in Studia Leibnitiana (in press)

Leibniz’s conception of the relativity of motion has been discussed at length for a very long time. This paper doesn’t aim to give a full solution to this question, but to contribute to the debate by ... [more ▼]

Leibniz’s conception of the relativity of motion has been discussed at length for a very long time. This paper doesn’t aim to give a full solution to this question, but to contribute to the debate by clarifying how the principle of relativity is introduced, justified and used in the Dynamica. Four different principles are identified : one purely geometrical, and three (meta)physical principles, which express God’s wisdom : a principle of equivalence of hypotheses linked to the action/reaction principle, a galilean principle of relativity and a general principle which apply not only to rectilinear motions but also to circular ones. I argue that to appreciate the coherence of Leibniz’ approach, we should distinguish these principles more sharply than he himself did and pay more attention to their status : are they consequences of the definition of motion, consequences of the physical laws or necessary conditions for any physical theory ? [less ▲]

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See detailProposal of a new tDCS safety screening tool TSST (Transcranial direct current stimulation Safety Screening Tool)
Bornheim, Stephen ULiege; Croisier, Jean-Louis ULiege; Maquet, Pierre ULiege et al

in American Journal of Physical Medicine and Rehabilitation (in press)

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See detailUn regard post-coloniliste de la médiatisation européenne à l'heure des Femen en Tunisie
Luceno Moreno, Marta ULiege

in Open Library of Humanities (in press)

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See detailLes critiques chrétiennes des lectisternes et sellisternes romains : un banquet trop anthropomorphe ?
Berthelet, Yann ULiege

in Les Cahiers du CEDOPAL (in press)

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See detailCross-cultural adaptation, translation, and validation of the functional assessment scale for acute hamstring injuries (FASH) questionnaire for French-speaking patients
Locquet, Médéa ULiege; Willems, Tom; Specque, Clément et al

in Disability and Rehabilitation (in press)

Study design: This consisted of a translation and validation study. Background: Acute hamstring injury is a frequent muscle strain in sports that require high explosive strength, impulsion or running ... [more ▼]

Study design: This consisted of a translation and validation study. Background: Acute hamstring injury is a frequent muscle strain in sports that require high explosive strength, impulsion or running phases. Therefore, the Functional Assessment Scale for Hamstring Injury questionnaire was developed to assess pain, physical activity level and ability to perform various exercises in patients with hamstring injuries. The Functional Assessment Scale for Hamstring Injury questionnaire is currently available in English, German, and Greek. Objectives: The goal of this study was to provide a cross-culturally adapted French-translation of the FASH questionnaire and to assess its psychometric performance. Methods: The French-translation and cross-cultural adaptation process were based on international recommendations, following six rigorous steps: (a) two initial translations from English to French; (b) synthesis of the two translations; (c) back-translations; (d) comparisons between the back-translations and the original questionnaire by an expert committee; (e) pretest; and (f) approval of the final French version of the Functional Assessment Scale for Hamstring Injury questionnaire. To validate this French version, 116 subjects (17 pathological patients, 19 patients with other muscle injury, 40 athletes at risk, and 40 healthy control athletes) were recruited to complete the Functional Assessment Scale for Hamstring Injury questionnaire. The Short Form Health Survey (SF-36) was used as a comparative questionnaire. The psychometric properties of the questionnaire were evaluated by determining the test-retest reliability after a 48–60-h interval, internal consistency, construct validity, and floor/ceiling effects. Results: All of the items of the Functional Assessment Scale for Hamstring Injury questionnaire were translated without any major difficulties. The questionnaire showed excellent discriminative power by obtaining significantly different scores from the four groups (p¼0.01). Regarding psychometric performances, the test–retest reliability was excellent (IntraClass Coefficient Correlation of 0.997). Very high internal consistency was also observed (Cronbach’s alpha of 0.969). Correlations with the physical health subscales of the SF-36 were significant and considered to be strong, indicating an excellent convergent validity. The other subscales of the SF-36 (mental health) were weakly correlated with the FASH, reflecting good divergent validity. No floor or ceiling effects were observed. Conclusion: The French-translation of the Functional Assessment Scale for Hamstring Injury questionnaire and its cross-cultural adaptation can be considered to be successful. Functional Assessment Scale for Hamstring Injury-French questionnaire is now a reliable and valid tool for patients suffering from acute hamstring injury, and its application in clinical practice is particularly relevant. IMPLICATIONS FOR REHABILITATION The FASH-F can be considered to be discriminant, reliable and valid for the evaluation of the severity of symptoms and sports ability in individuals with hamstring injuries. FASH-F is now a reliable and valid tool for French-speaking patients suffering from acute hamstring injury, and its application in clinical practice is particularly relevant. A limitation of our study could be that the distribution between the different study groups was not homogeneous implying that our findings may not be fully representative of the general population. [less ▲]

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See detailMeasuring dating violence: Conflict or non-conflict related instructions?
Courtain, Audrey ULiege; Glowacz, Fabienne ULiege

in European Review of Applied Psychology (in press)

Introduction. – Dating violence, as well as the broader field of intimate partner violence, has mainly been investigated with two conflict-related questionnaires (Conflict in Adolescent Dating ... [more ▼]

Introduction. – Dating violence, as well as the broader field of intimate partner violence, has mainly been investigated with two conflict-related questionnaires (Conflict in Adolescent Dating Relationship Inventory CADRI, Conflict Tactics Scale CTS). Indeed, the respondents have to report aggressive behaviors that occurred in a context of conflict. Such conflict-related instructions prevent us from investigating violence occurring outside a context of conflict. Objective. – The aim of the study was to explore whether the use of a conflict-related or a non-conflict-related version of the CADRI could impact dating violence prevalences and scores, and to investigate conceptual issues associated with conflict-related questionnaires.Method. – A total of 186 participants ranging in age from 16 to 23 years (M = 18.93, SD = 1.52, 64.5%girls) were administered a new version of the CADRI (i.e. with non-conflict related instructions) and then the original version of the CADRI (i.e. with conflict-related instructions). The instrument investigated threatening behaviors, relational, physical, sexual and verbal dating violence. Results. – For several forms of dating violence, prevalence rates and scores decreased from the non-conflict-related version to the conflict-related version: males showed more frequent drops than females.There were more frequent gender differences for rates and scores on the conflict-related version than onthe non-conflict-related version. Conclusion. – The use of non-conflict-related instructions is an opportunity not to limit the study of dating violence to behaviors occurring during a conflict or an argument. It allows a broader understanding ofdating violence beyond any conflict-related instruction. [less ▲]

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See detailOtro poeta en Nueva York. Gilberto Owen en Los ingrávidos (2011) de Valeria Luiselli
Vanden Berghe, Kristine ULiege; Licata, Nicolas ULiege

in Literatura Mexicana (in press), 31(enero-junio),

In the first novel written by Valeria Luiselli, Los ingrávidos (2011, translation in English: Faces in the crowd), the prominence of Gilberto Owen as a character indicates that Luiselli wishes to give a ... [more ▼]

In the first novel written by Valeria Luiselli, Los ingrávidos (2011, translation in English: Faces in the crowd), the prominence of Gilberto Owen as a character indicates that Luiselli wishes to give a renewed visibility to this Mexican artist and, at the same time, to create a self-image that legitimates her activity as a writer. Disarticulated content, continuous intertextuality and recurring metaliterary reflection, various of the commonalities which link up Luiselli’s poetic practice with that of Owen suggest that she vindicates a literary relationship that situates her in a family of Mexican vanguard writers. This filiation is even more explicit in the novel, because Luiselli turns Owen into a literary character (not without exaggerating some of the poet’s traits that are often associated with the figure of the artist, such as alcoholism or relational failure) and introduces him as her own double. [less ▲]

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See detailEWGSOP2 versus EWGSOP1: impact of the prevalence of sarcopenia and its major health consequences.
Locquet, Médéa ULiege; Beaudart, Charlotte ULiege; Petermans, Jean ULiege et al

in Journal of the American Medical Directors Association (in press)

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See detailTwo New Ur III Letters in the Louvre Museum
Colonna d'Istria, Laurent ULiege

in Rivista Degli Studi Orientali (in press)

This article provides the publication of two new Ur III letters kept at Louvre Museum. The content of these letters is concise as the majority of the Ur III administrative letters. The first one asks for ... [more ▼]

This article provides the publication of two new Ur III letters kept at Louvre Museum. The content of these letters is concise as the majority of the Ur III administrative letters. The first one asks for the return of persons before an inspection and the second letter asks for the release of one barge carrying sesame. [less ▲]

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See detailFactors of Variation of Soil Chemical Properties in Metalliferous Ecosystems of Tenke-Fungurume, Katanga, D. R. Congo
Kaya Muyumba, Donato ULiege; Ilunga wa Ilunga, Edouard; Faucon, Michel-Pierre et al

in Tropicultura (in press)

Our study aimed at deepen our understanding of relationships between soil properties and vegetation distribution in metalliferous ecosystems of Tenke-Fungurume in the Democratic Republic of Congo. The ... [more ▼]

Our study aimed at deepen our understanding of relationships between soil properties and vegetation distribution in metalliferous ecosystems of Tenke-Fungurume in the Democratic Republic of Congo. The first question concerned the differences and similarities between soils of the main vegetation units and four variation factors of soil properties were summarized by multivariate analysis. They were all linked to lithology and significantly contributed to explain the distribution of vegetation units. Our result suggest that the variation of soil properties which is observed within the various vegetation units (rocky steppe savanna, sward, and steppe savannas on slope or on Dembo) should partially be attributed to differences of geochemical composition of rocks between sites but the main source of variability is to be found inside each hill. The soil contamination in Cu and Co originates from rock weathering and besides site effect and topographic distribution of the rocks, the variability of soil properties within one vegetation unit may be due to variability of soil parent material and not only to erosion. The second question dealt with the changes of soil properties at small distances. Metric variation was studied from transects between adjacent vegetation units. Our results showed that the abrupt changes of vegetation units which were clearly identified on the field were all truly explained by the variations of one or more properties linked to lithology. The key point being the Cu bioavailability. [less ▲]

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See detailUsing a penalty term to deal with spurious oscillations in second gradient finite elements
Soufflet, Marc; Jouan, Gwendal; Kotronis, Panagiotis et al

in International Journal of Damage Mechanics (in press)

It is well known that it is necessary to introduce a length scale parameter in a continuum damage mechanics model to correctly simulate strain localization. The second gradient model, a special case of ... [more ▼]

It is well known that it is necessary to introduce a length scale parameter in a continuum damage mechanics model to correctly simulate strain localization. The second gradient model, a special case of kinematically enriched continua, considers an internal length parameter by taking into account the second order derivatives of the displacements in the virtual power principle. In this paper, we show that the original second gradient finite element of Chambon and co-workers can present spurious oscillations, especially for mode I crack propagation problems. After providing the plane stress second gradient constitutive law, we propose to add a penalty term in the original formulation in order to improve numerical convergence and to avoid spurious oscillations in the local variables distributions. Two numerical examples using classical damage mechanics laws, a three points reinforced concrete beam and a trapezoidal notched specimen are used to test the performance of the formulation. Parametrical studies are also shown on the influence of the penalty parameter. The problem of unrealistic damage spreading for damage values close to one, occurring often in mode I crack propagation problems, is finally discussed. [less ▲]

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See detailIntravenous lipid emulsions in paediatric patients
Lapillonne, A; Didler Mis, N; Goulet et al

in Clinical Nutrition (in press)

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See detailFirst geochimichal sourcing of 'Balkan flint' and 'Prut flint' from Palaeolithic Romania: potentials, limitations and future directions
Moreau, Luc; Ciornei, A.; Gjesfjelds, E. et al

in Archaeometry (in press)

Attributions of flint artefacts to specific geographical sources ideally require some form of independent validation through suitable petrographical and/or geochemical analyses, given the implications of ... [more ▼]

Attributions of flint artefacts to specific geographical sources ideally require some form of independent validation through suitable petrographical and/or geochemical analyses, given the implications of raw material transfer on interpretations of prehistoric mobility and land-use strategies. We investigated the potential to ‘fingerprint’ flint from two archaeological sites in Eastern Romania – Mitoc-Malu Galben and Bistricioara-Lutărie III, using Laser Ablation – Inductively Coupled Plasma – Mass Spectrometry (LA-ICP-MS) in combination with multivariate statistical analysis. Our results suggest that geochemical analyses do not yet have the level of resolution required to assign single artefacts to specific geographic locations in the context of Romania and Bulgaria. The mismatches of signatures between training and test data however raise new questions and open unforeseen perspectives. [less ▲]

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See detailL’activité éditoriale comme démarche de représentation de la connaissance: l’exemple de la ponctuation médiévale
Mazziotta, Nicolas ULiege

in Diachroniques: Revue de linguistique française diachronique (in press)

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See detailIlluminating Lives: The Biographical Impulse in Postcolonial Literatures
Ledent, Bénédicte ULiege; Tunca, Daria ULiege

in Journal of Commonwealth Literature (in press)

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See detailLe lettere bipartite e i discorsi politici di Francesco Guicciardini nell’anno 1525
Miesse, Hélène ULiege

in Giornale Storico della Letteratura Italiana (in press)

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See detailExtracorporeal photochemotherapy for graft versus host disease : Where we are now and where are we going !
Lewalle, Philippe; Beguin, Yves ULiege

in Belgian Journal of Hematology (in press)

Graft-versus-host disease (GVHD) remains the leading cause of morbidity, non-relapse mortality and treatment failure post allogeneic hematopoietic stem cell transplantation (allo-HSCT). So far, steroids ... [more ▼]

Graft-versus-host disease (GVHD) remains the leading cause of morbidity, non-relapse mortality and treatment failure post allogeneic hematopoietic stem cell transplantation (allo-HSCT). So far, steroids are the 1st line treatment but around 40% of patients become steroid-resistant or fail to respond at a safe dose. Patients who fail to respond to the initial therapy have a dismal prognosis and no standard treatment is well established for them to date. Treatments that modulate the immune system rather than directly suppressing its function, although not dampening a potential graft-versus-malignancy effect, would therefore be highly desirable and extracorporeal photopheresis (ECP) appeared as being a good candidate to fill in these criteria. Multiple reports of treatments in both paediatric and adult patients with GVHD have been published, and the overall favourable profile compared with other available immunosuppressive therapies continues to make ECP appealing despite all of the unknowns. In this article, we review the use of extracorporeal photopheresis for the treatment of graft-versus-host disease including technical aspects, mechanism of action, safety profile and clinical efficacy data [less ▲]

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See detailFictions de l’œuvre. Projets et textes possibles dans les romans de la vie littéraire
Saint-Amand, Denis ULiege

in Cahiers ReMIX (in press)

Le monde des études littéraires a vu se développer, au cours de ces dernières années, une théorie des textes possibles qui confronte la réception traditionnelle des œuvres (c’est-à-dire la façon dont leur ... [more ▼]

Le monde des études littéraires a vu se développer, au cours de ces dernières années, une théorie des textes possibles qui confronte la réception traditionnelle des œuvres (c’est-à-dire la façon dont leur lecture se concrétise la plupart du temps et le commentaire qu’on en livre habituellement) à une réinvention de leur signification, tirant parti des impensés de la fiction, des non-dits, des interactions interrompues, des blancs, des inférences labiles et autres zones creuses du récit qui offrent des prises pour une renégociation herméneutique. À côté des réinventions herméneutiques des œuvres classiques, de l’approche génétique et du fantasme programmatique autour des productions perdues, la critique des textes possibles aurait tout à gagner à explorer un continent fictionnel, fructueux en termes d’œuvres en puissance et qui recèle d’indications sur l’évaluation des modes et tendances d’une époque émanant des représentations des écrivains eux-mêmes : les œuvres imaginaires qui n’existent qu’en tant qu’elles sont inscrites dans d’autres œuvres, qui en esquissent les contours, les présentent voire les citent. Celles-là sont au cœur de la présente enquête, menée à partir du corpus rassemblé dans la base de données du GREMLIN ; on interroge dans cette contribution la façon dont, par métonymie, elles contribuent à une représentation fictionnelle de la vie littéraire. [less ▲]

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See detailModeling of coupled heat and mass transfer during drying of ebony wood using indirect natural convection solar dryer
Simo-Tagne, Merlin; Bonoma, B.; Bennamoun, L. et al

in Drying Technology (in press)

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See detailCompte-rendu de M. Lærke, Ch. Leduc, D. Rabouin, "Leibniz. Lectures et commentaires"
Dony, Arthur ULiege

in Revue Philosophique de Louvain (in press)

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See detailPhotologie, linéarité et modernité politique. Du geste philosophique derridien
Petteni, Oriane ULiege

in Éthique, Politique, Religions (in press), 1/n°12

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See detailLes troubles du sommeil chez l'enfant autiste, quel rôle pour le pédopsychiatre?
Abate Ekollo, Joëlle; Malchair, Alain ULiege

in Acta Psychiatrica Belgica (in press)

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants ... [more ▼]

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants souffrant de troubles du spectre autistique présentent un déficit de sommeil, qui peut durer jusqu’à l’adolescence. Les troubles du spectre autistique comportent des comorbidités multiples, dont des altérations du sommeil. Ils sont importants à caractériser dans cette population, car ils peuvent avoir un impact négatif sur les comportements diurnes. Par ailleurs, ils entrainent souvent des difficultés au sein de la famille. La prise en charge doit avant tout prendre en compte le contexte environnemental afin d’améliorer les habitudes et l’hygiène du sommeil. Des questionnaires ainsi que des agendas de sommeil ont été remplis par des parents afin de démontrer l’importance d’une évaluation et d’une prise en compte des troubles du sommeil chez les enfants souffrant d’autisme en consultation pédopsychiatrique. [less ▲]

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See detailConsequence of past anthropogenic forest fragmentation on the genetic structure of European mammals: the example of the edible dormouse (Glis glis)
Michaux, Johan ULiege; Hurner, H.; Krystufek, B et al

in Biological Journal of the Linnean Society (in press)

The genetic structure of forest animal species may allow the spatial dynamics of the forests themselves to be tracked. Two scales of change are commonly discussed: changes in forest distribution during ... [more ▼]

The genetic structure of forest animal species may allow the spatial dynamics of the forests themselves to be tracked. Two scales of change are commonly discussed: changes in forest distribution during the Quaternary, due to glacial/ interglacial cycles, and current fragmentation related to habitat destruction. However, anthropogenic changes in forest distribution may have started well before the Quaternary, causing fragmentation at an intermediate time scale that is seldom considered. To explore the relative role of these processes, the genetic structure of a forest species with narrow ecological preferences, the edible dormouse (Glis glis), was investigated in a set of samples covering a large part of its Palaearctic distribution. Strong and complex geographical structure was revealed from the use of microsatellite markers. This structure suggests that fragmentation occurred in several steps, progressively splitting the ancestral population into peripheral isolated ones. The fact that this structure postdates post-glacial recolonization, together with dating based on microsatellite data, supports the hypothesis that the differentiation was recent, starting around 9000 years ago, and took place stepwise, possibly up to Medieval times. This complements a classic phylogeographical interpretation based on the effect of past climate change, and supports the role of anthropogenic deforestation as a trigger of recent intraspecific differentiation. [less ▲]

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See detailProduction of 5‐hydroxymethylfurfural from D‐fructose in low‐transition‐temperature mixtures enhanced by chloride anions and low amounts of organic acids
Istasse, Thibaut ULiege; Bockstal, Lauris ULiege; Richel, Aurore ULiege

in ChemPlusChem (in press)

The research for safe and sustainable solvents able to solvate reagents and to catalyze their reactions at temperatures below 100°C is an innovative strategy to develop future lignocellulosic ... [more ▼]

The research for safe and sustainable solvents able to solvate reagents and to catalyze their reactions at temperatures below 100°C is an innovative strategy to develop future lignocellulosic biorefineries. Many low‐transition‐temperature mixtures (LTTMs) have been investigated for this purpose. Among them, natural deep eutectic solvents (NADESs) have been proposed as cheap and renewable alternatives to ionic liquids for the synthesis of bio‐based chemical building blocks. We compare herein the ability of several organic acids/choline chloride/water LTTMs to perform D‐fructose dehydration to 5‐hydroxymethylfurfural (5‐HMF). The addition of chloride salts as well as an increased proportion of choline chloride promote 5‐HMF formation which seem to indicate a beneficial effect of chloride anions on D‐fructose dehydration. Besides improving selectivity by at least 10%, increasing the choline chloride / acid ratio could enhance LTTMs biodegradability. Unlike other acidic components, maleic and citric acids are especially selective at early D‐fructose conversion. Maleic acid was the most selective acidic component among the tested chemicals allowing to achieve an 80% 5‐HMF molar yield in 1h at 90°C. [less ▲]

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See detailMitigation Techniques for Nappe Oscillations on Free-Overfall Structures
Lodomez, Maurine ULiege; Crookston, Brian ULiege; Tullis, Blake et al

in Civil Engineering ASCE (in press)

Nappe oscillation is a phenomenon that can have an undesirable impact to the local environmental (e.g., nearby residences, parks) as the phenomenon has been observed to produce a significant level of ... [more ▼]

Nappe oscillation is a phenomenon that can have an undesirable impact to the local environmental (e.g., nearby residences, parks) as the phenomenon has been observed to produce a significant level of noise caused by acoustic pressure waves. As a result, a detailed investigation was undertaken to identify practical and effective mitigation solutions to address these effects for free-overfall structures. Nappe oscillations were studied using a prototype-scale linear weir (weir length of 3.5 m and fall height of 3 m), a high-speed camera, and audio equipment. The effectiveness of various crest modifications to reduce nappe oscillation and any corresponding impacts to hydraulic efficiency were evaluated. The test matrix included the optimization (position and spacing of elements) of three mitigation solutions: 12 configurations with projecting elements, 5 configurations with deflectors and one configuration with a step. These three countermeasures proved to be effective after the optimization of their characteristics. In particular, deflectors or a step produced the maximum noise reduction while decreasing the discharge coefficient by less than 3 % over the range of experimental conditions. [less ▲]

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See detailDe l’usage de la photographie dans une enquête ethno-sociologique sur la mémoire de l’exil et de l’immigration espagnols en Belgique
Molina Marmol, Maïté ULiege

in RELAIS Revue du laboratoire d'études et de recherches sur l'interculturel (in press)

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See detailYouth’s Conflict Resolution Strategies in their Dating Relationships
Courtain, Audrey ULiege; Glowacz, Fabienne ULiege

in Journal of Youth and Adolescence (in press)

Youth can experience conflicts with their dating partner and then need strategies to solve such conflicts. Research is scarce regarding positive conflict resolution strategies in a dating context ... [more ▼]

Youth can experience conflicts with their dating partner and then need strategies to solve such conflicts. Research is scarce regarding positive conflict resolution strategies in a dating context. Considering research on various interpersonal relationships (e.g. friendships, dating, marriage), the present study examined how dimensions of empathy, verbal skills and impulsivity can contribute to the use of positive conflict resolution strategies in dating relationships. The sample is made up of 813 youth attending secondary schools or a regional college (71.7% female, mean age=18.9, age range 14.2-24.9). They completed self-administered questionnaires investigating positive conflict resolution strategies, as well as dimensions of empathy (i.e., fantasy, perspective-taking, empathic concern and personal distress), verbal skills (similarities and figurative language) and impulsivity (positive urgency, negative urgency, lack of premeditation, lack of perseverance and sensation seeking). The results reveal sex differences and developmental improvements on several factors. The findings showed that specific dimensions of empathy and verbal skills foster the use of positive conflict resolution strategies whereas specific dimensions of impulsivity and one dimension of empathy hamper it. Both sexes shared a common correlate: the propensity toward perspective-taking fostered the use of positive conflict resolution strategies. In addition to highlighting correlates of positive conflict resolution strategies in dating relationships, this study can contribute to programs dedicated to the promotion of healthy dating relationships among adolescents and emerging adults. [less ▲]

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See detailA dynamic and screening-compatible nanoluciferase-based complementation assay enables profiling of individual GPCR-G protein interactions
Laschet, Céline ULiege; Dupuis, Nadine; Hanson, Julien ULiege

in Journal of Biological Chemistry (in press)

G protein-coupled receptors (GPCRs) are currently the target of more than 30% of the marketed medicines. However, there is an important medical need for ligands with improved pharmacological activities on ... [more ▼]

G protein-coupled receptors (GPCRs) are currently the target of more than 30% of the marketed medicines. However, there is an important medical need for ligands with improved pharmacological activities on validated drug targets. Moreover, most of these ligands remain poorly characterized, notably because of a lack of pharmacological tools. Thus, there is an important demand for innovative assays that can detect and drive the design of compounds with novel or improved pharmacological properties. In particular, a functional and screening-compatible GPCR-G protein interaction assay is still unavailable. Here, we report on a nanoluciferase-based complementation technique to detect ligands that promote a GPCR-G protein interaction. We demonstrate that our system can be used to profile compounds with regard to the G proteins they activate through a given GPCR. Furthermore, we established a proof of applicability of screening for distinct G proteins on dopamine receptor D2 whose differential coupling to Gαi/o family members has been extensively studied. In a D2-Gαi1 versus D2- Gαo screening, we retrieved five agonists that are currently being used in antiparkinsonian medications. We determined that in this assay, piribedil and pergolide are full agonists for the recruitment of Gαi1 but are partial agonists for Gαo, that the agonist activity of ropinirole is biased in favor of Gαi1 recruitment, and that the agonist activity of apomorphine is biased for Gαo. We proposed that this newly developed assay could be used to develop molecules that selectively modulate a particular G protein pathway. [less ▲]

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See detailMood Disorders Patients Treated in a Day Hospital: Focus on Changes in Alexithymia and Openness to Emotions
Triffaux, Jean-Marc ULiege; Nasello, Julian ULiege; Servais, Catherine et al

in Clinical Psychiatry (in press)

Alexithymia and Openness to Emotions (OE) are strongly linked to mood disorders. Alexithymia represents the difficulty of giving words to emotions, whilst OE refers to cognitive representation ... [more ▼]

Alexithymia and Openness to Emotions (OE) are strongly linked to mood disorders. Alexithymia represents the difficulty of giving words to emotions, whilst OE refers to cognitive representation, communication and regulation aspects of emotions. We investigated variables impacting both alexithymia and OE for mood disorder patients (N = 73), before and after a treatment period in a day psychiatric hospital. Significant score changes and, notably, significant impacts of perceived social support were expected. [less ▲]

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See detailLes Trois Trois Petits Cochons et le Grand Méchant Loup. La rencontre de deux archétypes
Jousten, Lison ULiege

in La revue des lettres modernes (in press)

Image de la menace par excellence, le Grand Méchant Loup est un adversaire dont on ne compte plus les apparitions, notamment dans les fictions destinées au jeune public. Dans Les Trois Petits Cochons, qui ... [more ▼]

Image de la menace par excellence, le Grand Méchant Loup est un adversaire dont on ne compte plus les apparitions, notamment dans les fictions destinées au jeune public. Dans Les Trois Petits Cochons, qui s’impose comme cas d’école parmi ces récits où surgit l’animal redouté, le loup devient l’ennemi du cochon, une créature traditionnellement associée à l’enfance. Ce tandem, qui repose sur un principe général d’opposition, brasse avec lui une série de représentations qui transparaissent en filigrane. Le détour opéré par l’histoire culturelle du cochon et quelques-uns de ses prolongements cinématographiques permet de dessiner progressivement les contours de la place occupée par le loup dans ce conte. [less ▲]

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See detailWheels for people with disabilities in the post-apartheid city
Schnitzler, Marie ULiege

in Africa (in press)

This article focuses on technologies of mobility for people with physical disabilities living in a South African poor urban setting. It moves away from a perspective that exposes limitations to underline ... [more ▼]

This article focuses on technologies of mobility for people with physical disabilities living in a South African poor urban setting. It moves away from a perspective that exposes limitations to underline specific opportunities for people with disabilities to design the city. In the township of Mitchell’s Plain (Cape Town), known for its violence, defining when and where to use the chair involves a negotiation of moral and medical norms with a pursuit of security. In this process, the wheelchair constitutes one element of a larger continuum of wheeled mobility. The availability of public and private alternative transport enhances already present inequalities among people with disabilities. Two systems of public transport are further discussed, namely Dial-a-Ride (a specialized transport) and MyCiTi bus (a mainstream service). Initiatives of the City of Cape Town, these transports are widely discussed and criticized by people with disabilities. Through discussion with or opposition to the local government, associations participate actively in their inclusion in the post-apartheid city. My conclusions, drawn upon nineteen months of ethnographic fieldwork, call upon the theoretical framework of the anthropology of material things and the sociology of space. [less ▲]

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See detailIllness perceptions explain the variance in functional disability, but not habitual physical activity, in patients with chronic low back pain: A cross-sectional study
Leysen, Marijke; Nijs, Jo; Van Wilgen, Paul et al

in Pain Practice (in press)

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See detailLa Figure du délinquant. Essai de psychologie phénoménologique à partir du Saint Genet, comédien et martyr
Recchia, Fabio ULiege; Da Conceiçao Mestre, Alice

in Cercle Herméneutique (Le) (in press)

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See detailEvidence of freezing pressure in sea ice discrete brine inclusions and its impact on aqueous-gaseous equilibrium
Crabeck, Odile; Galley, R.J.; Mercury, L. et al

in Journal of Geophysical Research. Oceans (in press)

Sea ice in part controls surface water properties and the ocean-atmosphere exchange of greenhouse gases at high latitudes. In sea ice gas exists dissolved in brine and as air bubbles contained in liquid ... [more ▼]

Sea ice in part controls surface water properties and the ocean-atmosphere exchange of greenhouse gases at high latitudes. In sea ice gas exists dissolved in brine and as air bubbles contained in liquid brine inclusions, or as bubbles trapped directly within the ice matrix. Current research on gas dynamics within the ocean-sea ice-atmosphere interface has been based on the premise that brine with dissolved air becomes supersaturated with respect to the atmosphere during ice growth. Based on Henry’s Law, gas bubbles within brine should grow when brine reaches saturation during cooling, given that the total partial pressure of atmospheric gases is above the implicit pressure in brine of 1 atm. Using high-resolution light microscopy time series imagery of gas bubble evolution inside discrete brine pockets, we observed bubbles shrinking during cooling events in response to the development of freezing pressure above 3 atm. During warming of discrete brine pockets, existing bubbles expand and new bubbles nucleate in response to depressurization. Pressure variation within these inclusions has direct impacts on aqueous-gaseous equilibrium, indicating that Henry's Law at a constant pressure of 1 atm is inadequate to assess the partitioning between dissolved and gaseous fractions of gas in sea ice. This new evidence of pressure build-up in discrete brine inclusions controlling the solubility of gas and nucleation of bubbles in these inclusions has the potential to affect the transport pathways of air bubbles and dissolved gases within sea ice-ocean-atmosphere interface and modifies brine biochemical properties. [less ▲]

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See detailCommon Clays of Foumban area (West Cameroon): Variability, Distribution, Characterization and Potential Applications
Nkalih Mefire, Abiba ULiege

in Journal of African Earth Sciences (in press)

Common clay deposits from five localities in Foumban (West Cameroon) were investigated for their morphological, mineralogical and geochemical properties to determine their potential source rocks and ... [more ▼]

Common clay deposits from five localities in Foumban (West Cameroon) were investigated for their morphological, mineralogical and geochemical properties to determine their potential source rocks and suitability in ceramic product. The analytical results were obtained by X-ray diffraction, X-ray fluorescence spectrometry, Thermogravimetric Analysis, Scanning Electron Microscopy, and Fourier Transform Infrared Spectrometry. Morphologically, an homogeneous clayey layer was found in the upper part of a laterite cover on interfluves, and a clayey heterogeneous hydromorphic material in valleys. They are minerallogically composed of kaolinite (25-84%), illite (0-18%), smectite (0- 31%), and chlorite (0-8 %), associated with quartz (2-44 %), K-feldspars (0-27 %.), plagioclase (0-26%), goethite; (0-9%) with traces of rutile and hematite (≤5 %). The geochemical analysis shows a 115 relative large amount of SiO2 (45-71%), Al2O3 (14-31%), and low Fe2O3 (up to 11 %) suggesting weathering of mainly granitic and rhyolitic parent rocks. Most studied clays could be applied to building ceramic product such as bricks (refractory or not) and tiles. Illite may promote the glassy phase responsible for the densification of the final product. In addition, the relatively high proportion of alkali elements (K2O + Na2O, 6-8%) in some samples from Marom, Koutaba and is responsible for low firing temperature. However the presence of smectite (up to 5 %) limits the application of some Koutaba and Marom clays for ceramic building. The high Fe2O3 contents (> 8 %) in some Bangourain clays implied some pretreatment. [less ▲]

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See detailIs the triple stimulation technique a better quantification tool of motor dysfunction than motor evoked potentials in multiple sclerosis?
GIFFROY, Xavier ULiege; DIVE, Dominique ULiege; KAUX, Jean-François ULiege et al

in Acta Neurologica Belgica (in press)

The triple stimulation technique (TST) was rarely used in multiple sclerosis (MS). This study aimed to compare TST and motor evoked potentials (MEP) for the quantification of motor dysfunction. Central ... [more ▼]

The triple stimulation technique (TST) was rarely used in multiple sclerosis (MS). This study aimed to compare TST and motor evoked potentials (MEP) for the quantification of motor dysfunction. Central motor conduction based on MEP (four limbs) and TST (upper limbs) was assessed in 28 MS patients with a median Expanded Disability Status Scale (EDSS) of 4. EDSS, timed 25-foot walk (T25FW), grasping strength and motor components of the MS functional composite (MSFCm) were evaluated. Regression analysis was used to assess the relationship between MEP, TST and clinical findings. TST was negatively correlated with EDSS (r = -0.74, p<0.0001) and to a lesser extent with T25FW (r = -0.47, p<0.05), and grasping strength (r = -0.43, p<0.05). A multiple regression analysis underlined the better correlation between clinical data and TST (R2 = 0.56, p<0.0005) than with MEP (0.03<R2<0.22, p>0.05). This study evidenced the value of TST as a quantification tool of motor dysfunction. TST appeared to reflect a global disability since it was correlated not only to hand function but also to walking capacity. [less ▲]

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See detailPer una edizione integrale e analitica dell'incipit della Storia d'Italia di Francesco Guicciardini
Moreno, Paola ULiege

in Laboratoire Italien: Politique et Société (in press)

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See detailComment les chiens travaillent-ils ? Le cas des chiens détecteurs d’explosifs
Orianne, Jean-François ULiege; Lohay, Etienne ULiege

in Revue de l'Institut de Sociologie (in press)

This paper identifies some leads for the sociological analysis of the work of dogs, by taking the example of the explosive detection dogs within a private security company. The authors show that this ... [more ▼]

This paper identifies some leads for the sociological analysis of the work of dogs, by taking the example of the explosive detection dogs within a private security company. The authors show that this organization - like the federal police or the armed forces - makes the dog exists as a quasi-worker, by inserting him into the division of work, giving him a role (the detection of explosives), a specific status (auxiliary safety officer), based on a specific skill (knowledge of the world through the nose) and certified through professional training (followed in pairs). The complementarity of roles between the dog and the handler instituted by the company strongly frames work interactions, intensifies communication within the pair and generates a dynamic of reciprocal influence, under constraint of effectiveness. Anthropocanine working relationships are analyzed in terms of power, which, according to the authors, constitutes a privileged means of interspecies communication in the absence of a common language. [less ▲]

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See detailA new decision tree for diagnosis and management of osteoarthritis in primary care: international consensus of experts.
Martel-Pelletier, J.; Maheu, E.; Pelletier, J.P. et al

in Aging Clinical and Experimental Research (in press)

Background and aims: Although osteoarthritis (OA) is managed mainly in primary care, general practitioners (GPs) are not always trained in its diagnosis, which leads to diagnostic delays, unnecessary ... [more ▼]

Background and aims: Although osteoarthritis (OA) is managed mainly in primary care, general practitioners (GPs) are not always trained in its diagnosis, which leads to diagnostic delays, unnecessary resource utilization, and suboptimal patient outcomes. Methods: To address this situation, an International Rheumatologic Board (IRB) of 8 experts from 3 continents developed guidelines for the diagnosis of OA in primary care. The focus was three major topologies: hip, knee, and hand/finger OA. The IRB used American College of Rheumatology diagnostic criteria. Results: Care pathways based on clinical and radiological findings were developed to identify intervention thresholds for GPs/specialists. To optimize usefulness in the primary care setting, the guidelines were formatted as an uncomplicated, but comprehensive one-page decision tree for each topology, highlighting key aspects of the evaluation process and incorporating red flags. In a two-phase validation stage, the draft guidelines were evaluated by rheumatologists and GPs for project execution, content and perceived benefit. The strength of the guidelines lies in their user-friendly diagram and potential for broad application. Such guidelines will allow GPs to make an easy but definite diagnosis of OA and offer clear guidance about situations requiring an expert opinion. The guidelines have potential to improve patient outcomes and reduce the number of unnecessary procedures. Discussion and conclusions: This project demonstrated the feasibility of developing easy-to-use and effective visual decision trees to facilitate the diagnosis and management of OA of the hip, knee and hand/finger in primary care. The next step should be to conduct a large impact study of implementation of these recommendations in the diagnostic management of OA in general practice in different areas. [less ▲]

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See detailBryophyte biogeography
Patino, J; Vanderpoorten, Alain ULiege

in Critical Reviews in Plant Sciences (in press)

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See detailRôle et langue de Tchantchès dans les représentations en castelets des romans de chevalerie : le cas des Quatre fils Aymon
Baiwir, Esther ULiege; Impe, Anaëlle

in Enquêtes du Musée de la Vie Wallonne (in press)

Pourquoi et dans quelle mesure les montreurs de marionnettes liégeoises font-ils intervenir Tchantchès aux côtés des grands chevaliers médiévaux, dont les aventures constituent une part importante du ... [more ▼]

Pourquoi et dans quelle mesure les montreurs de marionnettes liégeoises font-ils intervenir Tchantchès aux côtés des grands chevaliers médiévaux, dont les aventures constituent une part importante du répertoire liégeois ? Quels sont ses moyens d'action, mais également ses modes d'expression ? Divers registres de langue apparaissent au fil des spectacles ; quels sont ceux prêtés à notre héros ? Et surtout, ce rôle et cette langue ont-ils évolué au fil du temps ? C’est à ces quelques questions que nous tentons de répondre, en observant les différentes interventions de Tchantchès dans les réécritures des aventures des quatre fils Aymon, l’une des œuvres les plus anciennes et les plus fréquemment jouées dans les théâtres liégeois dévolus aux comédiens de bois. [less ▲]

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See detailThe developmental neural substrates of item and serial order components of verbal working memory
Attout, Lucie ULiege; Ordonez Magro, Laura; Szmalec, Arnaud et al

in Human Brain Mapping (in press)

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See detailMe and the NGO staff, We Live like Azungu; Malawian Moral Economies of Development
Mc Namara, Thomas ULiege

in Human Organization (in press), 78 (2019)(21),

This article explores how rural Malawians used an NGO’s presence to negotiate their changing intra-community responsibilities. It responds to a perceived incompatibility between development and kinship ... [more ▼]

This article explores how rural Malawians used an NGO’s presence to negotiate their changing intra-community responsibilities. It responds to a perceived incompatibility between development and kinship-inspired moral economies by exploring how “becoming developed” became a (contested) way to fulfil intra-communal obligations and entitlements, which were previously enacted through resource sharing. It also shows how villagers’ understanding that donors were a patron for their entire community encouraged them to make demands on the NGO’s project’s beneficiaries. These findings should persuade practitioners to consider how their projects will be reinterpreted through community-embedded concepts of obligation and the effects of their mere presence on local meanings of development. [less ▲]

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See detailEnjeux politiques et critiques d'une philosophie des normes
Caeymaex, Florence ULiege; Pieron, Julien ULiege

in Dissensus (in press)

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See detailL’Église des Piémontais à Rome au début du XVIIe siècle. Les “musiques extraordinaires” d’une nation composite
Morales, Jorge ULiege

in Revue Belge de Musicologie (in press), 73

Cet article présente les premiers résultats des recherches archivistiques sur la vie musicale de l’Église nationale des Piémontais à Rome. La construction de cette église va de pair avec la construction ... [more ▼]

Cet article présente les premiers résultats des recherches archivistiques sur la vie musicale de l’Église nationale des Piémontais à Rome. La construction de cette église va de pair avec la construction de l’identité et l’affirmation politique d’un duché qui, de « territoire tampon, devient un État intermédiaire » . Cette contribution permet d’examiner les transferts de sacralité qui s’opèrent entre le duché de Piémont-Savoie et la Ville éternelle, la manière dont cette église devient le théâtre de l’affirmation politique et sociale de la famille de Savoie, mais également la circulation des musiciens locaux et venus d’ailleurs qui font de l’église de la nation piémontaise un laboratoire de l’identité savoyarde à Rome. [less ▲]

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See detailNotice brève sur l'ouvrage de O. Dubreucq : L'instruction des laïcs de Jonas d'Orléans
Close, Florence ULiege

in Revue d'Histoire Ecclésiastique (in press)

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See detailRiver habitat homogenisation enhances trophic competition and promotes individual specialisation among young of the year fish
Latli, Adrien; Michel, Loïc ULiege; Lepoint, Gilles ULiege et al

in Freshwater Biology (in press)

In large rivers, the success of ontogenic development of fish is mainly influenced by resource availability and by the possibility of species to adapt their diet (i.e. trophic niche). Human have ... [more ▼]

In large rivers, the success of ontogenic development of fish is mainly influenced by resource availability and by the possibility of species to adapt their diet (i.e. trophic niche). Human have drastically modified freshwater habitats, notably for navigation purposes. Such modifications may drastically affect food availability for young of the year (YOY) fish and, consequently, influence their ability to reach the adult age. In the River Meuse, a decrease of fish abundance is thought to be linked to a drastic decrease of phytoplankton biomass. In this context of lowering phytoplankton biomass, we quantified the trophic niches of three cyprinid species (common bleak Alburnus alburnus, chub Squalius cephalus, and roach Rutilus rutilus) and one percid species (European perch Perca fluviatilis) at various stages of development, in order to estimate the influence of river channelization in the intra and interspecific competitions. It was done using stable isotope analysis in two reaches of the River Meuse differing by their degree of regulation. We hypothesized that habitat heterogeneity increases YOY abundance over time by offering more alternative resources which reduce food competition, notably during the early period of life. Our study provides evidence that the River Meuse flow and depth regulation significantly impacted the abundance and taxonomic diversity of YOY. In the context of low planktonic biomass, most YOY relied on benthic food sources. In the heavily channelized reach, between-stages competition and low resource diversity increased the diet partition between cyprinid larvae and forced a part of individuals to consume non-optimal energetic food sources such as aquatic vegetation. On the other hand, in the less channelized reach, larvae displayed a generalist feeding habit focusing on energetic prey such as different taxa of macroinvertebrates, suggesting that the diversity of habitat reduces the food competition within and between stages and the predation risk. Developing a sustainable and integrated river management may be useful for protecting biodiversity and restoring ecosystem function, in order to improve the ecological potential of regulated rivers. [less ▲]

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See detailExternal Quality Assessment of 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) assays.
Carter, G. D.; Ahmed, F.; Berry, J. et al

in The Journal of steroid biochemistry and molecular biology (in press)

The discovery that mutations of the CYP24A1 gene are a cause of idiopathic infantile hypercalcemia (IIH) has revived interest in measuring serum 24,25(OH)2D3. Several studies have also suggested that a ... [more ▼]

The discovery that mutations of the CYP24A1 gene are a cause of idiopathic infantile hypercalcemia (IIH) has revived interest in measuring serum 24,25(OH)2D3. Several studies have also suggested that a high 25-hydroxyvitamin D3(25-OHD3):24,25(OH)2D3 ratio might provide additional diagnostic information in the investigation of vitamin D deficiency. Measurement of 24,25(OH)2D3 is necessarily restricted to laboratories with mass spectrometry methods although cross reactivity of the metabolite in immunoassays for 25-OHD is a potential cause of misleading results. The international External Quality Assessment (EQA) scheme for vitamin D metabolites (DEQAS) was set up in 1989. In 2013 DEQAS became an accuracy based EQA for 25-OHD with 'target values' assigned by the National Institute of Standards and Technology (NIST) Reference Measurement Procedure (RMP). A pilot scheme for serum 24,25(OH)2D3 was started in 2015 and participants were asked to measure the metabolite on each of the 5 samples sent out for 25-OHD. Inter-laboratory agreement was poor but this may reflect methodological differences, in particular different approaches to assay standardization. An important potential contribution to reducing variability among assays was the development by NIST of a 24,25(OH)2D3 RMP and its use in assigning values to SRMs 972a, 2973 and 2971, supported by the NIH Office of Dietary Supplements (ODS) as part of the Vitamin D Standardization Program (VDSP) effort. [less ▲]

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See detailEmpirical Evidence on the Market Power, Business Model, Banking Stability and Performance in the Emerging Economies
Yudha Sudrajad, Oktofa; Hübner, Georges ULiege

in Eurasian Business Review (in press)

This paper studies the nexus between banks’ market power and business model represented by non-interest income and non-deposit short-term funding share. We also examine the impact of bank business model ... [more ▼]

This paper studies the nexus between banks’ market power and business model represented by non-interest income and non-deposit short-term funding share. We also examine the impact of bank business model on banking stability and performance. We use a sample made up with six ASEAN country banking sectors from 2002 to 2015. We find that banks with a strong capital base but lower net interest margin perform better in translating their market power to generate non-traditional income as alternative soruce of revenues. Our findings also show that the implementation of Basel 2 Accord encourages banks to create non-interest income from trading & derivatives activities. We also document that banks with higher market power tend to increase non-deposit short-term funding in their banking scheme. In the evaluation of the banking stability, our results suggest that banks with greater non-traditional income are associated with less banking overall risk. Moreover, non-traditional incomes also contribute to better bank performance. [less ▲]

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See detailConsensus report: Peri-implant diseases and conditions
Berglundh, Tord; Armitage, Gary; Avila-Ortiz, Gustavo et al

in Journal of Periodontology (in press)

A classification for peri-implant diseases and conditions was presented. Focused questions on the characteristics of peri-implant health, peri-implant mucositis, periimplantitis, and soft- and hard-tissue ... [more ▼]

A classification for peri-implant diseases and conditions was presented. Focused questions on the characteristics of peri-implant health, peri-implant mucositis, periimplantitis, and soft- and hard-tissue deficiencies were addressed. Peri-implant health is characterized by the absence of erythema, bleeding on probing, swelling, and suppuration. It is not possible to define a range of probing depths compatible with health; of more importance are the clinical signs of inflammation. Peri-implant health can exist around implants with reduced bone support.The main clinical characteristic of peri-implant mucositis is bleeding on gentle probing. Erythema, swelling, and/or suppuration may also be present. An increase in probing depth is often observed in the presence of peri-implant mucositis due to swelling or decrease in probing resistance. There is strong evidence from animal and human experimental studies that plaque is the etiological factor for peri-implant mucositis. Peri-implantitis is a plaque-associated pathological condition occurring in tissues around dental implants, characterized by inflammation in the peri-implant mucosa and subsequent progressive loss of supporting bone. Peri-implantitis sites exhibit clinical signs of inflammation, bleeding on probing, and/or suppuration, increased probing depths and/or recession of the mucosal margin in addition to radiographic bone loss. The evidence is equivocal regarding the effect of keratinized mucosa on the longterm health of the peri-implant tissue. It appears, however, that keratinized mucosa may have advantages regarding patient comfort and ease of plaque removal. Case definitions in day-to-day clinical practice and in epidemiological or diseasesurveillance studies for peri-implant health, peri-implant mucositis, and periimplantitis were introduced. The proposed case definitions should be viewed within the context that there is no generic implant and that there are numerous implant designs with different surface characteristics, surgical and loading protocols. It is recommended that the clinician obtain baseline radiographic and probing measurements following the completion of the implant-supported prosthesis. [less ▲]

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See detailEuropean experience and risk factor analysis of donor cell-derived leukaemias/MDS following haematopoietic cell transplantation.
Engel, Nicole; Rovo, Alicia; Badoglio, Manuela et al

in Leukemia (in press)

Donor cell leukaemia (DCL) is a rare complication of allogeneic haematopoietic cell transplantation (HCT). We have investigated the prevalence and outcome of donor cell haematology malignancies within ... [more ▼]

Donor cell leukaemia (DCL) is a rare complication of allogeneic haematopoietic cell transplantation (HCT). We have investigated the prevalence and outcome of donor cell haematology malignancies within centres registered with the European Society of Blood and Marrow transplantation (EBMT). We have sought to identify risk factors to shed light on the pathogenesis of DCL as a model for leukaemogenesis. DCL cases were identified by questionnaire and a follow-up questionnaire requested detailed data. Control subjects from the EBMT registry who had not developed DCL were used for a matched pair analysis to identify risk factors. We identified 38 patients with DCL; the estimated prevalence was 80.5/100,000 transplants. Patients were predominantly treated for haematological malignancy. A clone was retrospectively identified in 7/25 (28%) donors for whom data was available. Overall survival was poor with 29/38 patients dead a median of 11 (range 0-91) months after DCL diagnosis. Matched case-pair analysis identified three factors on multivariate analysis as significantly associated with an increased risk for DCL: use of growth factors within the first 100 days after transplantation, in vivo T-cell depletion and multiple allografts. The risk factors identified, support reduced immune surveillance and replicative stress as pathogenic in the development of DCL. [less ▲]

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See detailAttitudes towards personhood in the locked-in syndrome: from third- to first- person perspective and interpersonal significance
Nizzi, Marie-Christine; Blandin, Veronique; Demertzi, Athina ULiege

in Neuroethics (in press)

Personhood is ascribed on others, such that someone who is recognized to be a person is bestowed with certain civils rights and the right to decision-making. A rising question is how severely brain ... [more ▼]

Personhood is ascribed on others, such that someone who is recognized to be a person is bestowed with certain civils rights and the right to decision-making. A rising question is how severely brain-injured patients who regain consciousness can also regain their personhood. The case of patients with locked-in syndrome (LIS) is illustrative to this matter. Upon restoration of consciousness, patients with LIS find themselves in a state of profound demolition of their bodily functions. From the third-person perspective, it can be expected that LIS patients might experience a differential personal identity and maybe lose their status of persons. However, from the patients’ standpoint, it is uncontested that they retain their personal identity and they consider themselves as persons. We here assist this perspective by including self-reports from patients with LIS aimed at identifying the primary expectations of patients for their care by non-medical professionals. Based on these first-hand reports, we argue that personhood in LIS is progressively regained as the widening circle of others recognizes them as persons. [less ▲]

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See detailEffect of Air-gap on Response of Fabricated Slim Floor Beams in Fire
Alam, Naveed; Nadjai, Ali; Maraveas, Chrysanthos ULiege et al

in Journal of Structural Fire Engineering (in press)

Fabricated slim floor beams are a type of shallow floor systems which are formed by welding a steel plate to the bottom flange of an I-shaped steel section. The welded steel plate adds asymmetry to the ... [more ▼]

Fabricated slim floor beams are a type of shallow floor systems which are formed by welding a steel plate to the bottom flange of an I-shaped steel section. The welded steel plate adds asymmetry to the steel section and improves its structural response by efficient utilization of the material strength. During their fabrication process, an air-gap is induced between the steel plate and the bottom flange, which, at elevated temperatures, acts as a layer of insulation and influences the temperature development across their section. Due to the presence of this air-gap, temperatures on the bottom flange remain lower in fire conditions, hence, these beams offer an improved fire resistance in comparison to other similar beam types. This study addresses the thermal and structural response of fabricated slim floor beams at elevated temperatures and investigates the influence of the air-gap. Finite element modelling is performed to analyse the response of these beams in fire and the predicted behaviour is validated by replicating the experimental data from the literature. The elaborated finite element modelling method is then employed to conduct sensitivity studies to investigate the effect of the presence and size of the air-gap on their thermal and structural response at elevated temperatures. Results from the studies demonstrate that the presence of the air-gap has a considerable influence on their thermal behaviour, however, the size of the air-gap has no or negligible effect on their thermal behaviour. The structural analyses show that the presence of the air-gap has a significant influence on the structural response of fabricated slim floor beams at elevated temperatures. The size of the air-gap, however, has no significant influence on their structural response in fire. As the presence of air-gap is helpful and beneficial, the findings of this research can be used to develop similar designs for structural members as an efficient and inexpensive way to improve their thermal behaviour and structural response in fire. [less ▲]

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See detailA threesome is healthier than a love triangle: connecting planetary health, climate change and migration
Schütte, Stefanie; Gemenne, François ULiege; Depoux, Anneliese et al

in The Lancet Planetary Health (in press)

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See detailA situated expert judgment: QSAR models and transparency in the European regulation of chemicals
Thoreau, François ULiege; Laurent, Brice

in Science & Technology Studies (in press)

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See detailMaqriziana XIV: Al-Maqrīzī’s Last Opus (Al-Ḫabar ʿan al-Bašar) and Its Significance for the History of Islam
Bauden, Frédéric ULiege

in Journal of the Royal Asiatic Society (in press)

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See detailDo Alzheimer’s disease patients benefit from prior-knowledge in associative recognition memory?
Delhaye, Emma ULiege; Folville, Adrien ULiege; Simoes Loureiro, Isabelle et al

in Journal of the International Neuropsychological Society (in press)

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See detailFormes narratives et jugement : réflexions sur l'identité dans l'espace médiatique
Servais, Christine ULiege

in Sociologie (in press)

L’auteure s’attache dans cet article à définir plusieurs formes d’apparitions publiques de l’identité en les mettant en relation avec le jugement. L’hypothèse qui est défendue est que les événements ... [more ▼]

L’auteure s’attache dans cet article à définir plusieurs formes d’apparitions publiques de l’identité en les mettant en relation avec le jugement. L’hypothèse qui est défendue est que les événements racontés dans un « récit de soi » (qu’il soit ou non à la première personne) le sont dans le cadre d’une relation d’interpellations réciproques. Cette relation façonne l’identité et lui donne forme, en même temps qu’elle appelle le public à en répondre de différentes manières, et appelle par conséquent différentes formes de jugements publics. Sont ainsi distingués le drame, la narration, la récitation et le récit. Ce lien entre identité et jugement est illustré par des exemples puisés dans la presse écrite puis par l’analyse d’une une vidéo youtube [less ▲]

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See detailIndications de l'autogreffe dans la sclérose en plaques : recommandations de la Société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC) en lien avec la Société francophone de la sclérose en plaques
Zephir, H.; Puyade, M.; Gueguen, A. et al

in Bulletin du Cancer (in press)

The Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) organized the 8th allogeneic hematopoietic stem cell transplantation clinical practices harmonization workshop series ... [more ▼]

The Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) organized the 8th allogeneic hematopoietic stem cell transplantation clinical practices harmonization workshop series in September 2017 in Lille, France. In this article we give the indications of autologous stem cell transplantation in multiple sclerosis as well as recommendations regarding post-transplant follow-up of patients under the hospice of the SFGM-TC and the Francophone Society of Multiple Sclerosis. © 2018 [less ▲]

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See detailTiwouh: an enriched technology-based solution for communication interventions
Fage, Charles ULiege; Giblet, Sarah ULiege; Jaspard, Marie et al

in Association for the Advancement of Modelling and Simulation Techniques in Enterprises (in press)

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See detailExploring the suitability of RanBP2-type Zinc Fingers for RNA-binding protein design
De Franco, Simona; Vandenameele, Julie; Brans, Alain et al

in Scientific Reports (in press)

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See detailPoor Vitamin K Status Is Associated With Low Bone Mineral Density and Increased Fracture Risk in End-Stage Renal Disease.
Evenepoel, Pieter; Claes, Kathleen; Meijers, Bjorn et al

in Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research (in press)

Chronic kidney disease and osteoporosis are major public health problems associated with an aging population. Vitamin K insufficiency is prevalent among patients with end-stage renal disease (ESRD ... [more ▼]

Chronic kidney disease and osteoporosis are major public health problems associated with an aging population. Vitamin K insufficiency is prevalent among patients with end-stage renal disease (ESRD). Preliminary data indicate that poor vitamin K status may compromise bone health and that increased inflammation may be in the causal pathway. We performed an ancillary analysis of data collected in the frame of prospective observational cohort studies exploring various aspects of bone health in de novo renal transplant recipients to investigate the association between vitamin K status, inflammation, bone mineral density, and incident clinical fractures. Parameters of mineral metabolism (including biointact PTH and FGF23, sclerostin, calcidiol, calcitriol) and inflammation (CRP and IL-6), osteoprotegerin, bone turnover markers (P1NP, BsAP, and TRAP5B), and dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP) were assessed on blood samples collected immediately prior to kidney transplantation in 468 patients. Areal bone mineral density (aBMD) was measured at the lumbar spine and femoral neck by dual-energy X-ray absorptiometry within 14 days posttransplant. Poor vitamin K status, defined by dp-ucMGP >500 nmol/L, was highly prevalent (90%). High dp-ucMGP levels independently associated with elevated inflammatory markers and low aBMD. No associations were observed between vitamin K status and bone turnover markers. During a median follow-up of 5.1 years, 33 patients sustained a fragility fracture. In Cox-proportional hazards analysis, a dp-ucMGP above median associated with incident fractures, independent of classical determinants, including age, gender, history of fracture, and aBMD (HR 2.21; 95% CI, 1.00 to 4.91; p < 0.05). In conclusion, poor vitamin K status associates with inflammation and low aBMD in patients with ESRD and confers an increased risk of incident fractures in de novo renal transplant recipients. (c) 2018 American Society for Bone and Mineral Research. [less ▲]

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See detailPathways of running away among Belgian youth
Glowacz, Fabienne ULiege; Léonard, Julie; Courtain, Audrey ULiege

in Youth and Society (in press)

Runaway behaviors among teenagers have been studied for some 40 years. Still, because runaway and homeless youths have often been confounded, little is known about what really defines a runaway adolescent ... [more ▼]

Runaway behaviors among teenagers have been studied for some 40 years. Still, because runaway and homeless youths have often been confounded, little is known about what really defines a runaway adolescent. This study targets three objectives in a mixed-method design relying on data from official files and interviews: the descriptions of teenagers reported as missing (e.g., age, sex, runaway duration and reiteration, place left behind, type of caller reporting the child as missing, motivation for closing the file) and the understanding of runaway pathways and dynamics. These studies can contribute to prevention and intervention programs by providing new perspectives on how runaway experiences should be understood in light of the adolescent process. [less ▲]

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See detailAbaloparatide is an effective treatment option for postmenopausal osteoporosis: review of the number needed to treat compared with teriparatide.
Reginster, Jean-Yves ULiege; Hattersley, G.; Williams, G et al

in Calcified Tissue International (in press)

Abaloparatide (ABL) is a 34-amino acid peptide designed to be a selective activator of the parathyroid hormone receptor type 1 signaling pathway. In the Abaloparatide Comparator Trial In Vertebral ... [more ▼]

Abaloparatide (ABL) is a 34-amino acid peptide designed to be a selective activator of the parathyroid hormone receptor type 1 signaling pathway. In the Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE), subcutaneous ABL reduced the risk of new vertebral, nonvertebral, clinical, and major osteoporotic fracture compared with placebo and of major osteoporotic fracture compared with teriparatide. To further evaluate the effectiveness of ABL, we calculated the number needed to treat (NNT) to prevent one fracture using ACTIVE data. To estimate the potential effectiveness of ABL in populations at higher fracture risk than in ACTIVE, we calculated NNT for vertebral fracture using reference populations from historical placebo-controlled trials, assuming an 86% relative risk reduction in vertebral fracture with ABL treatment as observed in ACTIVE. NNT was calculated as the reciprocal of the absolute risk reduction in ACTIVE. The projected NNT for ABL in other populations was calculated based on incidence rate (IR) for vertebral fractures in the placebo arms of the FREEDOM (placebo IR 7.2%), FIT-1 (placebo IR 15.0%), and FIT-2 (placebo IR 3.8%) trials. NNT for ABL in ACTIVE was 28 for vertebral, 55 for nonvertebral, 37 for clinical, and 34 for major osteoporotic fracture. NNT for these fracture types for teriparatide in ACTIVE were 30, 92, 59, and 75, respectively. Using placebo IRs from FREEDOM, FIT-1, and FIT-2, projected NNTs for vertebral fracture with ABL were 17, 8, and 31. These data are useful for further evaluating ABL for the treatment of osteoporosis in postmenopausal women. [less ▲]

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See detailThe value of integrating order picking and vehicle routing decisions in a B2C e-commerce environment
Moons, Stef; Braekers, Kris; Ramaekers, Katrien et al

in International Journal of Production Research (in press)

In B2C e-commerce sales, customers expect a fast and low-cost delivery. To be able to fulfill these customer expectations, both warehouse and distribution operations have to be performed in an efficient ... [more ▼]

In B2C e-commerce sales, customers expect a fast and low-cost delivery. To be able to fulfill these customer expectations, both warehouse and distribution operations have to be performed in an efficient and effective way. Ideally, these two supply chain functions should be considered simultaneously in an integrated problem since they are interrelated. In this paper, a record-to-record travel algorithm is proposed to solve the integrated order picking-vehicle routing problem (I-OP-VRP). Experiments with both small-size and large-size instances are conducted. Furthermore, the integrated approach is compared with an approach in which both problems are solved sequentially. Results show that integration leads to increased service levels, i.e., it allows to shorten the time between placing an order and receiving the goods. On top, the integrated approach leads to costs savings of on average 1.8%. Thus, integration is indispensable for a fast and cost-efficient delivery of goods. [less ▲]

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See detailIron and Trace Element in Paediatric Parenteral Nutrition
Domellof, M; Szitanyi, P; Simchowitz, V et al

in Clinical Nutrition (in press)

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See detailVerbal working memory and the phonological buffer: The question of serial order.
Majerus, Steve ULiege

in Cortex: A Journal Devoted to the Study of the Nervous System and Behavior (in press)

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See detailCharacterizing the Eemian-Weichselian transition in northwestern Europe with three multiproxy speleothem archives from two Belgian cave systems (Han-sur-Lesse and Remouchamps).
Vansteenberge, Stef; Verheyden, Sophie; Genty, Dominique et al

in Quaternary Science Reviews (in press)

Interglacial to glacial transitions represent the most drastic turnovers in the Quaternary climate system. Yet, millennial-scaled climate variability and stochastic internal variability that result in ... [more ▼]

Interglacial to glacial transitions represent the most drastic turnovers in the Quaternary climate system. Yet, millennial-scaled climate variability and stochastic internal variability that result in these transitions remain still poorly understood. Here, three speleothem archives from two different cave systems in Belgium (Han-sur-Lesse and Remouchamps) are investigated using a multiproxy approach in order to characterize the last interglacial to glacial transition. The studied samples roughly span the period between 125 ka and 100 ka, covering a large part of the Eemian and early Weichselian. The speleothems show a high reproducibility for δ13C, which is interpreted as a proxy for past vegetation activity, controlled by vegetation assembly above the cave. All three speleothems show a drastic increase in δ13C between 118 to 117 ka, reflecting a rapid change of vegetation assembly from last interglacial temperate tree species towards glacial more open grass vegetation. This event shows a strong affinity in terms of timing and climatic expression with the Late Eemian Aridity Pulse (LEAP) at 118 ± 1 ka, identified in pollen records from Western Germany. Aligning the chronologies of the two independently dated Han-sur-Lesse speleothem records enables a more precise absolute chronology and provides an age of 117.7 ± 0.5 ka to the start of this event in the Belgian speleothems. This event marks a distinct transition in the Belgian speleothem proxies between Eemian optimum conditions and increased variability during the glacial inception and the start of this event at 117.7 ± 0.5 ka is therefore proposed as the Eemian- Weichselian transition and consequently the start of the glacial inception in the studied speleothems. High-resolution analysis shows that the 117.7 ± 0.5 ka event is initiated by a cooling pulse followed by a decrease in precipitation. A similar short-lived cooling event is also registered in multiple North-Atlantic sediment archives. This study hypothesizes that the origin of the cooling event at 117.7 ka is an internal climate response caused by the substantial amount of freshwater input from degraded ice-sheets by the end of the Eemian (~120-118 ka). There is thus a clear climatic connection between the Belgian speleothems and other continental European archives and North Atlantic marine archives, providing the possibility of improving less constrained chronologies by alignment to the independently constructed speleothem age-depth model presented in this study. [less ▲]

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See detailLes haruspices publics au service de Rome : des aristocrates convoqués d’Étrurie ? Quels aristocrates ?
Berthelet, Yann ULiege

in Dialogues d'Histoire Ancienne (in press)

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See detailHumor Associated with Positive Outcomes in Individual Psychotherapy
Panichelli, Christophe ULiege; Albert, Adelin ULiege; Donneau, Anne-Françoise ULiege et al

in American Journal of Psychotherapy (in press), APT-2018-0021

Considerable anecdotal evidence points to the usefulness of humor in the therapeutic process, but empirical evidence is still lacking. This study searched for an association between humor and therapy ... [more ▼]

Considerable anecdotal evidence points to the usefulness of humor in the therapeutic process, but empirical evidence is still lacking. This study searched for an association between humor and therapy outcomes in a real-life population of 110 adult psychotherapy clients who attended at least 10 therapy sessions. Clients and their therapist evaluated the frequency and intensity of humorous events, as well as therapy effectiveness, therapeutic alliance, perceived hope and pleasure to participate in therapy sessions. We found a strong positive correlation between humor and therapy effectiveness, in both client (rs = .40; p < .0001) and therapist perspectives (rs = .37; p < .0001). The link between humor and effectiveness remained significant in more severe subgroups of clients, even though these clients reported less humor in their therapies. Further research is needed to determine if humor actually enhances therapy outcomes, or if positive outcomes trigger the occurrence of humor. [less ▲]

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See detailRecension critique de l'édition de S. De Sanctis : Il Mistero provenzale di sant'Agnese
Henrard, Nadine ULiege

in Revue Critique de Philologie Romane (in press), 2017(XVIII), 48-61

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See detailA lubricant boundary condition for a biological body lined by a thin heterogeneous biofilm
El Jarroudi, Mustapha; Hajjami, r.; Lahrouz, a. et al

in International Journal of Biomathematics (in press)

We study the asymptotic behavior of an incompressible viscous fluid flow in a biological body lined by a thin biological film with a cellular microstructure, varying thickness, and a heterogeneous ... [more ▼]

We study the asymptotic behavior of an incompressible viscous fluid flow in a biological body lined by a thin biological film with a cellular microstructure, varying thickness, and a heterogeneous viscosity regulated by a time random process. Letting the thickness of the film tend to zero, we derive an effective biological slip boundary condition on the boundary of the body. This law relates the tangential fluxes to the tangential velocities via a proportional coefficient corresponding to the energy of some local problem. This law describes the ability of the biological film to function as a lubricant reducing friction at the wall of the body. The tangential velocities are functions of the random trajectories of a finely concentrated biological particle. [less ▲]

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See detailUnderstanding osteoporotic pain and its pharmacological treatment: supplementary presentation
Vellucci, R; Terenzi, R; Kanis, J.A. et al

in Osteoporosis International (in press)

Osteoporosis, a disorder that affects millions of people worldwide, is characterized by decreased bone mass and microstructural alterations giving rise to an increased risk of fractures. Osteoporotic ... [more ▼]

Osteoporosis, a disorder that affects millions of people worldwide, is characterized by decreased bone mass and microstructural alterations giving rise to an increased risk of fractures. Osteoporotic fractures can cause acute and chronic nociceptive and neuropathic pain that mainly affects elderly patients with multiple comorbidities and commonly on different drug regimens. Central sensitization seems to play a pivotal role in developing and maintaining chronicity of post-fracture pain in osteoporosis. Antiosteoporosis drugs are able to partially control pain, but additional analgesics are always necessary for pain due to bone fractures. Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors reduce acute pain but with a poor effect on the chronic neuropathic component of pain and with relevant side effects. Opioid drugs can control the whole spectrum of acute and chronic bone pain, but they differ with respect to their efficacy on neuropathic components, their tolerability and safety. Chronic pain after osteoporotic fractures requires a multifaceted approach, which includes a large spectrum of drugs (antiosteoporosis treatment, acetaminophen, NSAIDs, selective COX-2 inhibitors, weak and strong opioids) and non-pharmacological treatment. Based on a better understanding of the pathogenesis of osteoporotic and post-fracture pain, a guided stepwise approach to post-fracture osteoporotic pain will also better meet the needs of these patients. [less ▲]

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See detailGenetic structure of lake and stream populations in a Pyrenean amphibian (Calotriton asper) reveals evolutionary significant units associated with paedomorphosis
Oromi Farrús, Neus ULiege; Valbuena-Ureña, Emilio; Soler-Membrives, Anna et al

in Journal of Zoological Systematics and Evolutionary Research (in press)

Differences in environmental conditions such as those between lakes and streams can produce phenotypic variation and ultimately promote evolutionary diversification. Some species of newts and salamanders ... [more ▼]

Differences in environmental conditions such as those between lakes and streams can produce phenotypic variation and ultimately promote evolutionary diversification. Some species of newts and salamanders can occupy these habitats and express alternative phenotypes: metamorphs that lose gills at metamorphosis and paedomorphs that retain them at the adult stage. Whereas this process is facultative in some species, it is obligatory in others, thus suggesting that isolation and environmental pressures may have canalized developmental pathways. In this study, we focused our research on the Pyrenean brook newt, Calotriton asper which is present in both lakes and streams, but whose fully aquatic paedomorphic individuals are only present in lakes. We aimed to determine the genetic structure and differentiation of two paedomorphic populations, including their surrounding stream and lake metamorphic populations, to test whether populations of paedomorphs can constitute evolutionary significant units. Although gene flow was identified between lakes and nearby stream populations, there was a low percentage of dispersers, and the paedomorphic populations were genetically differentiated from the populations of metamorphs. It is likely that the studied lakes have offered peculiar conditions that have allowed the development of a paedomorphic phenotype. These populations and phenotypes therefore constitute good models to understand local adaptations. As each of these populations of paedomorphs can be considered evolutionary significant units that cannot be replaced by other nearby populations in case of a population crash, conservation actions should be focused directly on them. [less ▲]

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See detailLe syndrome de Klinefelter : actualités cliniques et thérapeutiques
VALDES SOCIN, Hernan Gonzalo ULiege; Rey, R; COPPENS, Luc ULiege et al

in Vaisseaux, Coeur, Poumons (in press), 24(1),

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See detailPsychosocial transition to retirement and adjustment to retired life: influence on well-being and mental health in retired farmers.
Laberon, sonia; Grotz, Catherine ULiege; Amieva, Hélène et al

in Aging and Society (in press)

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See detailPaclitaxel-loaded multifunctional nanoparticles for the targeted treatment of glioblastoma
Ganipineni, Lakshmi Pallavi; Ucakar, Bernard; Joudiou, Nicolas et al

in Journal of Drug Targeting (in press)

We hypothesized that the active targeting of αvβ3 integrin overexpressed in neoangiogenic blood vessels and glioblastoma (GBM) cells combined with magnetic targeting of paclitaxel- and SPIO-loaded PLGA ... [more ▼]

We hypothesized that the active targeting of αvβ3 integrin overexpressed in neoangiogenic blood vessels and glioblastoma (GBM) cells combined with magnetic targeting of paclitaxel- and SPIO-loaded PLGA-based nanoparticles could improve accumulation of nanoparticles in the tumor and therefore improve the treatment of GBM. Methods: PTX/SPIO PLGA nanoparticles with or without RGD-grafting were characterized. Their in vitro cellular uptake and cytotoxicity was evaluated by fluorospectroscopy and MTT assay. In vivo safety and anti-tumor efficacy of different targeting strategies was evaluated in orthotopic U87MG tumor model over multiple intravenous injections. Results: The nanoparticles of 250nm were negatively charged. RGD targeted nanoparticles showed a specific and higher cellular uptake than untargeted nanoparticles by activated U87MG and HUVEC cells. In vitro IC50 of PTX after 48h was approximately 1 ng/mL for all the PTX-loaded nanoparticles. The median survival time of the mice treated with magnetic targeted nanoparticles was higher than the control (saline) mice or mice treated with other evaluated strategies. The 6 doses of PTX did not induce any detectable toxic effects on liver, kidney and heart when compared to Taxol. Conclusion. The magnetic targeting strategy resulted in better therapeutic effect than the other targeting strategies (passive, active). [less ▲]

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See detailErythropoiesis and iron metabolism after hematopoietic stem cell transplantation
JASPERS, Aurélie ULiege; Beguin, Yves ULiege

in Belgian Journal of Hematology (in press)

After hematopoietic stem cell transplantation (HCT), many patients present anemia, which can persist for months due to an inadequate Epo production for the degree of the anemia. In this thesis, we ... [more ▼]

After hematopoietic stem cell transplantation (HCT), many patients present anemia, which can persist for months due to an inadequate Epo production for the degree of the anemia. In this thesis, we performed two randomized studies with erythropoiesis-stimulating agents (ESA) therapy after allogeneic (including myeloablative and non-myeloablative conditioning) and autologous transplantation. We showed a great efficacy of this growth factor to ensure full erythroid reconstitution when initiated soon after engraftment, and not immediately after the transplant. Furthermore, as iron parameters are quite disturbed following HCT, we sought to study iron metabolism after HCT (which has not been much investigated), integrating the role of hepcidin, the key regulator in iron metabolism. Hence, we demonstrated that hepcidin levels prior to and following autologous HCT were influenced by iron stores and changes in erythropoietic activity [less ▲]

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See detailγ Doradus stars as test of angular momentum transport models
Ouazzani, R-M; Marques, J P; Goupil, M-J et al

in Astronomy and Astrophysics (in press)

Helioseismology and asteroseismology of red giant stars have shown that the distribution of angular momentum in stellar interiors, and its evolution with time remains an open issue in stellar physics ... [more ▼]

Helioseismology and asteroseismology of red giant stars have shown that the distribution of angular momentum in stellar interiors, and its evolution with time remains an open issue in stellar physics. Owing to the unprecedented quality of Kepler photometry, we are able to seismically infer internal rotation rates in γDoradus stars, which provide the MS counterpart to the red-giants puzzle. We confront these internal rotation rates to stellar evolution models with rotationally induced transport of angular momentum, in order to test angular momentum transport mechanisms. We used a stellar model-independent method developed by Christophe et al. in order to obtain seismically inferred, buoyancy radii and near-core rotation for 37 γ Doradus stars observed by Kepler. We show that the buoyancy radius can be used as a reliable evolution indicator for field stars on the MS. We computed rotating evolutionary models including transport of angular momentum in radiative zones, following Zahn and Maeder, with the CESTAM code. This code calculates the rotational history of stars from the birth line to the tip of the RGB. The initial angular momentum content has to be set initially, which is done by fitting rotation periods in young stellar clusters. We show a clear disagreement between the near-core rotation rates measured in the sample and the rotation rates obtained from evolutionary models including rotationally induced transport following Zahn (1992). These results show a disagreement similar to that of the Sun and red giant stars. This suggests the existence of missing mechanisms responsible for the braking of the core before and along the MS. The efficiency of the missing mechanisms is investigated. The transport of angular momentum as formalized by Zahn and Maeder cannot explain the measurements of near-core rotation in main-sequence intermediate-mass stars we have at hand. [less ▲]

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See detailCalcium, phosphorus and magnesium in Paediatric Parenteral Nutrition
Fewtrell, mary; Goulet, Olivier; Mihatsch, Walter et al

in Clinical Nutrition (in press)

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See detailOvercoming familiarity illusions in a single case with persistent déjà vu
Ernst, Alexandra ULiege; DELRUE, Gaël ULiege; Willems, Sylvie ULiege

in Memory (in press)

While occasional déjà vu is benign in the general population, rare neuropsychological cases with persistent déjà vu have been described in the literature. We report the case of MN, a 25-year-old woman ... [more ▼]

While occasional déjà vu is benign in the general population, rare neuropsychological cases with persistent déjà vu have been described in the literature. We report the case of MN, a 25-year-old woman, who suffered a cerebral haemorrhage in the right thalamo-callosal region and experienced recurrent déjà vu episodes. Through clinical interviews and memory tasks related to déjà vu, we assumed that source memory errors and an inappropriate feeling of familiarity (measured by the number of false recognitions) were critically involved in MN’s déjà vu. Based on this, we developed the first neuropsychological intervention dedicated to déjà vu. The rationale was to train MN to detect elements that could produce an inappropriate feeling of familiarity and to promote metacognitive awareness about déjà vu. This intervention was effective at reducing the frequency of déjà vu episodes in MN’s daily life, as well as the number of false recognitions in memory tasks. In addition to its clinical contribution, this single-case study contributes to the limited literature on patients whose déjà vu is not related to epileptic abnormalities and medial temporal brain damage, and provide supportive evidence of the role of an erroneous feeling of familiarity and of metacognitive processes in déjà vu. [less ▲]

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See detailMeasuring impulsivity in Children: Adaptation and Validation of a Short Version of the UPPS-P Impulsive Behaviors Scale in Children and Investigation of Its Links with ADHD
Geurten, Marie ULiege; Catale, Corinne ULiege; Gay, Philippe et al

in Journal of Attention Disorders (in press)

Objective: Impulsivity is a multifaceted construct known to play a crucial role in the development and maintenance of a wide range of problematic behaviors and psychological disorders in children. Method ... [more ▼]

Objective: Impulsivity is a multifaceted construct known to play a crucial role in the development and maintenance of a wide range of problematic behaviors and psychological disorders in children. Method: In this study, we adapted the short French adult version of the UPPS-P Impulsive Behavior Scale for use with children (short UPPS-P-C) and tested its psychometric properties. Results: Confirmatory factor analyses conducted on a sample of 425 children (aged from 8 to 14 years) supported the five-factor structure of the scale. Additional analyses emphasized the good internal and test-retest reliability of the short UPPS-P-C. Furthermore, our results also revealed that lack of premeditation and urgency subscales were able to discriminate between children diagnosed with attention-deficit/hyperactivity disorder (ADHD) and their matched controls. Conclusion: These results suggest that the short UPPS-P-C may be considered as a promising time-saving tool to assess impulsivity traits in healthy children and in children with psychiatric disorders. [less ▲]

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See detailLipids or Proteins: Who is leading the dance at Membrane Contact Sites?
Petit, Jules ULiege; Immel, Françoise; Lins, Laurence ULiege et al

in Frontiers in Plant Science (in press)

Understanding the mode of action of membrane contact sites (MCSs) across eukaryotic organisms at the near-atomic level to infer function at the cellular and tissue levels is a challenge scientists are ... [more ▼]

Understanding the mode of action of membrane contact sites (MCSs) across eukaryotic organisms at the near-atomic level to infer function at the cellular and tissue levels is a challenge scientists are currently facing. These peculiar systems dedicated to inter-organellar communication are perfect examples of cellular processes where the interplay between lipids and proteins is critical. In this mini review, we underline the link between membrane lipid environment, the recruitment of proteins at specialized membrane domains and the function of membrane contact sites. More precisely, we want to give insights on the crucial role of lipids in defining the specificity of plant endoplasmic reticulum (ER)-plasma membrane (PM) MCSs and we further propose approaches to study them at multiple scales. Our goal is not so much to go into detailed description of MCSs, as there are numerous focused reviews on the subject, but rather try to pinpoint the critical elements defining those structures and give an original point of view by considering the subject from a near-atomic angle with a focus on lipids. We review current knowledge as to how lipids can define MCS territories, play a role in the recruitment and function of the MCS-associated proteins and in turn, how the lipid environment can be modified by proteins. [less ▲]

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See detailConservation Ethics in the 21th Century: Towards an Extended Toolkit
Houbart, Claudine ULiege; Dawans, Stéphane ULiege

in Heritage for Future (in press)

In his now classic essay on the « Régimes d’historicité », the French historian François Hartog (2003) has very well described the effect of globalisation, democratisation and mass consumerism on our ... [more ▼]

In his now classic essay on the « Régimes d’historicité », the French historian François Hartog (2003) has very well described the effect of globalisation, democratisation and mass consumerism on our relation with the past and thus, with heritage. In the course of the 1970’s, at a time when the ink of the Venice Charter was barely dry, postmodernity triggered a loss of collective anchoring and memory, paradoxically accompanied by an amplification of the thirst for commemorations, in the name of identity or heritage. Pierre Nora’s great endeavour « Les lieux de mémoire », fully corresponds to this « presentism » era, including aside from monuments, museum and archives, intellectual constructions such as the Larousse encyclopaedia (Nora 1989). It very well illustrates the « extension of the heritage domain » as defined by the sociologist Nathalie Heinich (2009). In our « post-monumental » era, anything can possibly become heritage, regardless of scale, of artistic qualities, of age or ontological degree – from tangible to intangible. This is a sign of times. Following the example of Nelson Goodman replacing the essentialist definitions of art with the question « When is there art ? » (Goodman 1976), we should consider focusing on a dynamic and operational definition of heritage. The question « When is there heritage ?» better correspond to contemporary cultural studies and our attempt to understand « heritagization »; it contains the idea of a performative action, implying new actors, new dynamics, new process, new research questions, new difficulties and new opportunities. And by necessity new concepts. We are far from rejecting theories from the past which provided us with effective and stimulating tools. But who could still imagine today, in the situation we described, that any system could fully encompass the heritage reality as the grand theories – Brandi, Riegl,… – succeeded to do? The repeated attempts to get the Venice charter revised from the 1970’s on (Houbart 2014), and the multiplication of thematic documents and charters are the best illustration of this impossibility. But while postmodern thinkers made us suspicious towards large systems, they also made us more modest and above all, more inclined to respect « bricolage », as a most helpful attitude after a shipwreck. We believe that the current return to a case by case approach – as promoted from the interwar period by theoreticians such as Ambrogio Annoni (1946) – often mostly relying on practical constraints such as reuse and technical performances, combined with the use of decontextualised concepts – separated articles from the Venice Charter, for example – and practices – using the Ise shrine periodical rebuilding to advocate any reconstruction project – doesn’t mean to accept a cynical relativism in answer to the cause of a capital-intensive machine. But in practice, we cannot deny that it has sometimes been the case: the clearest examples are the debates addressing the reconstruction of monuments all over Europe, based on a jumble of arguments confusing the pure mercantilism of the tourism industry or unconfessed political reasons with post-conflict identity issues or religious traditions (Monumental 2010). Reflecting on such reconstruction projects, raising questions of identity, has convinced us of the incompleteness of the toolkit we inherited from 20th century theoreticians. Though still perfectly relevant to address the issues that were already present at the time when they were elaborated, they might prove inappropriate to address new types of heritage, new concerns, new issues such as cultural tourism, inclusive approaches, modern heritage or the digital turn. In this context, we have been drawn to look at texts outside the conservation sphere, starting from ontology of art and analytical philosophy. We discovered that taking a step to the side could provide a stimulating insight on heritage conservation problems. In fact, it is not surprising that, facing what many have called a heritage inflation, some new actors could help us. Now that heritage has quitted the monuments sphere to encompass any material or immaterial reality worthy of conservation and that the expert point of view is challenged by the ones of a broad range of stakeholders, from the user to the investor, it becomes interesting to look at this reality from different points of view borrowed to a wide range of human sciences such as law, communication, aesthetics, semiotics, anthropology or philosophy, to name a few. Together with our colleague Muriel Verbeeck, we are currently gathering texts in order to propose an anthology that could complement the existing ones in helping to fill conceptual gaps and throw a reinvigorating light on new problems raising old questions. The originality of the project is to chose most texts outside the conservation world, and to address movable and immovable heritage at the same time. During our presentation, we will provide some examples of the usefulness of these new concepts, some already known by a number of conservators – such as the distinction proposed by Nelson Goodman between allography and autography (Goodman 1976) –, some not – the impact of intention on identity, based on texts by Theodore Scaltsas (1981), for example –, and will encourage the members of the committee who might be interested in this approach to contribute to the project. [less ▲]

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See detailLes espaces verts en zone urbaine et périurbaine de Kinshasa
Sambieni, Kouagou Raoul ULiege; Useni, Sikuzani Yannick; Cabala, Kaleba Sylvestre et al

in Tropicultura (in press)

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See detailIntégrer le droit international au champ des relations internationales : les juristes belges à Versailles en 1919
Genin, Vincent ULiege

in Relations internationales (in press), (2),

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See detailCapillary electrophoretic mobility shift competition assay for the assessment of weak drug-protein interactions
Farcas, Elena ULiege; Hanson, Julien ULiege; Pochet, Lionel et al

in Analytica Chimica Acta (in press)

Only few reports describe the use of capillary electrophoresis in the context of Fragment Based Drug Discovery (FBDD). In this paper, we will present a generic, fully automated, microscale electrophoretic ... [more ▼]

Only few reports describe the use of capillary electrophoresis in the context of Fragment Based Drug Discovery (FBDD). In this paper, we will present a generic, fully automated, microscale electrophoretic mobility shift competition assay that can be used in FBDD for primary screening of weak biomolecular interactions between fragments and target protein. The accuracy and reliability of the present method was demonstrated by measuring the interaction between two known fragments inhibiting thrombin, namely benzamidine and p-aminobenzamidine and a relatively weak inhibitor, nafamostat. The measured IC50 were found to be in good accordance with the previously reported ones. Furthermore, we built a small chemical library to evaluate the performance and the advantage of our newly developed screening-bioassay compared to the direct affinity capillary electrophoresis-binding assay. The results demonstrate the high discriminatory power of the method and above all its ability to screen neutral, negatively or positively charged molecules, as well as molecules that have no or low UV-VIS absorbance, greatly expanding the scope of the assay. Finally, we proved that this approach is able to discriminate between competitive binders and irreversible binders. Altogether, this work demonstrates that capillary electrophoresis could constitute an important added value in the arsenal used to screen fragments in drug discovery. [less ▲]

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See detailUnder which humidity conditions are moss spore released? A comparison between species with perfect and specialized peristomes
Zanatta, F.; Vanderpoorten, Alain ULiege; Hedenäs, L. et al

in Ecology and Evolution (in press)

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See detailConstruction cognitive d’un motif : cooccurrences textuelles et associations mémorielles
Longrée, Dominique ULiege; Mellet, Sylvie; Lavigne, Frederic

in CogniTextes (in press)

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See detailStandard versus individualized parenteral nutrition
Riskin, A; Picaud, J-C; Shamir, R et al

in Clinical Nutrition (in press)

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See detailIdentification of flower functional traits affecting abundance of generalist predators in perennial multiple species wildflower strips
Hatt, Séverin ULiege; Uyttenbroeck, Roel; Lopes, Thomas et al

in Arthropod-Plant Interactions (in press)

In agricultural fields, wildflower strips can be sown to enhance conservation biological control of insect pests. However, issues remain regarding the composition of flower mixtures to effectively attract ... [more ▼]

In agricultural fields, wildflower strips can be sown to enhance conservation biological control of insect pests. However, issues remain regarding the composition of flower mixtures to effectively attract and support large communities of natural enemies. Trait-based approaches are promising for this purpose. In the present study, conducted in an agricultural field of Belgium in 2014 and 2015, 15 flower mixtures were considered to explore the relation between the abundance of trapped generalist predators (i.e. lacewings [Neuroptera: Chrysopidae], ladybeetles [Coleoptera: Coccinellidae] and hoverflies [Diptera: Syrphidae]) and the community-weighted means of seven flower traits. Through a redundancy analysis, it was found that the presence/absence of flower ultra-violet pattern and the morphology of the corolla (that determines the accessibility of floral resources) were the traits that significantly affected the abundance of the generalist predators in the flower mixtures. The ladybeetles Harmonia axyridis and Propylea quatuordecimpunctata as well as the lacewings Chrysoperla carnea were more abundant in mixtures with a high cover of flowers showing an ultra-violet pattern, while the opposite was observed for the ladybeetle Coccinella septempunctata. As for hoverflies, Episyrphus balteatus and Eupeodes corollae were more abundant in mixtures with a high cover of flowers with open nectar. These results bring new knowledge regarding how a range of natural enemy species reacts to flower cues in diversified plant communities and should help in elaborating flower mixtures that enhance conservation biological control. [less ▲]

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See detailVitamins in Paediatric Parenteral Nutrition
Bronski, J; Campoy, C; Braegger, C et al

in Clinical Nutrition (in press)

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See detailFrench translation and validation of the “Anterior Knee Pain Scale” (AKPS)
Buckinx, Fanny ULiege; Bornheim, Stephen ULiege; Remy, G. et al

in Disability and Rehabilitation (in press)

Purpose: To linguistically and cross-culturally translate the Anterior Knee Pain Scale into French and to evaluate the reliability and validity of this translated version of the questionnaire. Methods ... [more ▼]

Purpose: To linguistically and cross-culturally translate the Anterior Knee Pain Scale into French and to evaluate the reliability and validity of this translated version of the questionnaire. Methods: The translation part was performed in six stages, according to international guidelines: (i) two initial translations from English to French; (ii) synthesis of the two translations; (iii) backward translations into the original language; (iv) expert committee to compare the backward translations with the original questionnaire; (v) pre-final version testing and (VI) expert committee appraisal. To validate the French version of the Anterior Knee Pain Scale, we assessed its validity, reliability and floor/ceiling effects. To do this, volunteer patients from the French part of Belgium and from France, with patellofemoral pain were asked to answer the French version of the Anterior Knee Pain Scale at baseline and after 7 days, as well as the generic SF-36 questionnaire. Results: The Anterior Knee Pain Scale was translated without any major difficulties. A total of 101 subjects aged 34.5 ± 11.4 years (58.4% of women) were included in this study. Results indicated an excellent test-retest reliability (Intra-class correlation coefficient (ICC) = 0.97, 95%CI: 0.96–0.98), a high internal consistency (Cronbach’s alpha = 0.87), a consistent construct validity (high correlations with the SF-36 questionnaire were found with domains related to physical function (r = 0.80), physical role (r = 0.70) and pain (r = 0.64)) and low or moderate correlations with domains related to mental health (r = 0.26), vitality (r = 0.32) and social function (r = 0.41). Moreover, no floor/ceiling effects have been found. Conclusions: A valid French version of the Anterior Knee Pain Scale is now available and can be used with confidence to better assess the disease burden associated with patellofemoral pain. It was successfully cross-culturally adapted into French.Implications for rehabilitationThe results on psychometric properties of the French Anterior Knee Pain Scale are comparable with six validated versions obtained for the Finnish, the Turkish, the Chinese, the Dutch, the Thai and the Persian populations.The French translated version of the Anterior Knee Pain Scale is a reliable and valid instrument for assessing the functional limitations associated with patellofemoral pain.The test–retest reliability of the French Anterior Knee Pain Scale was excellent, the internal consistency was high and the construct validity was consistent. There were no floor/ceiling effects. © 2017 Informa UK Limited, trading as Taylor & Francis Group [less ▲]

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