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See detailPaclitaxel-loaded multifunctional nanoparticles for the targeted treatment of glioblastoma
Ganipineni, Lakshmi Pallavi; Ucakar, Bernard; Joudiou, Nicolas et al

in Journal of Drug Targeting (in press)

We hypothesized that the active targeting of αvβ3 integrin overexpressed in neoangiogenic blood vessels and glioblastoma (GBM) cells combined with magnetic targeting of paclitaxel- and SPIO-loaded PLGA ... [more ▼]

We hypothesized that the active targeting of αvβ3 integrin overexpressed in neoangiogenic blood vessels and glioblastoma (GBM) cells combined with magnetic targeting of paclitaxel- and SPIO-loaded PLGA-based nanoparticles could improve accumulation of nanoparticles in the tumor and therefore improve the treatment of GBM. Methods: PTX/SPIO PLGA nanoparticles with or without RGD-grafting were characterized. Their in vitro cellular uptake and cytotoxicity was evaluated by fluorospectroscopy and MTT assay. In vivo safety and anti-tumor efficacy of different targeting strategies was evaluated in orthotopic U87MG tumor model over multiple intravenous injections. Results: The nanoparticles of 250nm were negatively charged. RGD targeted nanoparticles showed a specific and higher cellular uptake than untargeted nanoparticles by activated U87MG and HUVEC cells. In vitro IC50 of PTX after 48h was approximately 1 ng/mL for all the PTX-loaded nanoparticles. The median survival time of the mice treated with magnetic targeted nanoparticles was higher than the control (saline) mice or mice treated with other evaluated strategies. The 6 doses of PTX did not induce any detectable toxic effects on liver, kidney and heart when compared to Taxol. Conclusion. The magnetic targeting strategy resulted in better therapeutic effect than the other targeting strategies (passive, active). [less ▲]

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See detailUn regard post-coloniliste de la médiatisation européenne à l'heure des Femen en Tunisie
Luceno Moreno, Marta ULiege

in Open Library of Humanities (in press)

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See detailDo Alzheimer’s disease patients benefit from prior-knowledge in associative recognition memory?
Delhaye, Emma ULiege; Folville, Adrien ULiege; Simoes Loureiro, Isabelle et al

in Journal of the International Neuropsychological Society (in press)

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See detailLocal predation risk and matrix permeability interact to shape movement strategy
Winandy, Laurane ULiege; Cote, Julien; Di Gesu, Lucie et al

in Oikos (in press)

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See detailVariable selection in proportional hazards cure model with time-varying covariates, application to US bank failures
Beretta, Alessandro ULiege; Heuchenne, Cédric ULiege

in Journal of Applied Statistics (in press)

From a survival analysis perspective, bank failure data are often characterized by small default rates and heavy censoring. This empirical evidence can be explained by the existence of a subpopulation of ... [more ▼]

From a survival analysis perspective, bank failure data are often characterized by small default rates and heavy censoring. This empirical evidence can be explained by the existence of a subpopulation of banks likely immune from bankruptcy. In this regard, we use a mixture cure model to separate the factors with an influence on the susceptibility to default from the ones affecting the survival time of susceptible banks. In this paper, we extend a semi-parametric proportional hazards cure model to time-varying covariates and we propose a variable selection technique based on its penalized likelihood. By means of a simulation study, we show how this technique performs reasonably well. Finally, we illustrate an application to commercial bank failures in the United States over the period 2006-2016. [less ▲]

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See detailRedéfinir et développer des compétences d’accueil de la petite enfance
Pirard, Florence ULiege; Housen, Marie ULiege; Pools, Elodie ULiege

in Journal for Educators, Teachers and Trainers (in press)

The competences expected from early childhood education and care professionals have evolved significantly in our Western countries following the transformation of services and the affirmation of their ... [more ▼]

The competences expected from early childhood education and care professionals have evolved significantly in our Western countries following the transformation of services and the affirmation of their educational function. This article is based on action research projects carried out in the Wallonia Brussels Federation (FWB) which integrate an analysis of other education and training systems (France, Flanders, England, Sweden and Quebec). It presents a reflection on the development of professional competencies and their acquisition from the initial training in a holistic approach to education. It notes that a diversity of formations coexists, leading to an absence of clear view on professional skills and profiles. In response to this observation, it proposes a modeling that articulates organizational, relational and reflexive competencies that are needed for the development of a professional posture. That modeling is presented as a grid of analysis that can enable better understanding of the complexity of early education and care in its many dimensions (working with children, families, professionals and the local community). It can be considered as a tool to globally rethink initial and continuing education and training in a systemic perspective. [less ▲]

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See detailCompte rendu de A. Arjava, J. Frösén, J. Kaimio, The Petra Papyri V, Amman, American Center of Oriental Research, 2018
Carlig, Nathan ULiege

in Byzantion: Revue Internationale des Études Byzantines (in press)

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See detailCross-cultural adaptation, translation, and validation of the functional assessment scale for acute hamstring injuries (FASH) questionnaire for French-speaking patients
Locquet, Médéa ULiege; Willems, Tom; Specque, Clément et al

in Disability and Rehabilitation (in press)

Study design: This consisted of a translation and validation study. Background: Acute hamstring injury is a frequent muscle strain in sports that require high explosive strength, impulsion or running ... [more ▼]

Study design: This consisted of a translation and validation study. Background: Acute hamstring injury is a frequent muscle strain in sports that require high explosive strength, impulsion or running phases. Therefore, the Functional Assessment Scale for Hamstring Injury questionnaire was developed to assess pain, physical activity level and ability to perform various exercises in patients with hamstring injuries. The Functional Assessment Scale for Hamstring Injury questionnaire is currently available in English, German, and Greek. Objectives: The goal of this study was to provide a cross-culturally adapted French-translation of the FASH questionnaire and to assess its psychometric performance. Methods: The French-translation and cross-cultural adaptation process were based on international recommendations, following six rigorous steps: (a) two initial translations from English to French; (b) synthesis of the two translations; (c) back-translations; (d) comparisons between the back-translations and the original questionnaire by an expert committee; (e) pretest; and (f) approval of the final French version of the Functional Assessment Scale for Hamstring Injury questionnaire. To validate this French version, 116 subjects (17 pathological patients, 19 patients with other muscle injury, 40 athletes at risk, and 40 healthy control athletes) were recruited to complete the Functional Assessment Scale for Hamstring Injury questionnaire. The Short Form Health Survey (SF-36) was used as a comparative questionnaire. The psychometric properties of the questionnaire were evaluated by determining the test-retest reliability after a 48–60-h interval, internal consistency, construct validity, and floor/ceiling effects. Results: All of the items of the Functional Assessment Scale for Hamstring Injury questionnaire were translated without any major difficulties. The questionnaire showed excellent discriminative power by obtaining significantly different scores from the four groups (p¼0.01). Regarding psychometric performances, the test–retest reliability was excellent (IntraClass Coefficient Correlation of 0.997). Very high internal consistency was also observed (Cronbach’s alpha of 0.969). Correlations with the physical health subscales of the SF-36 were significant and considered to be strong, indicating an excellent convergent validity. The other subscales of the SF-36 (mental health) were weakly correlated with the FASH, reflecting good divergent validity. No floor or ceiling effects were observed. Conclusion: The French-translation of the Functional Assessment Scale for Hamstring Injury questionnaire and its cross-cultural adaptation can be considered to be successful. Functional Assessment Scale for Hamstring Injury-French questionnaire is now a reliable and valid tool for patients suffering from acute hamstring injury, and its application in clinical practice is particularly relevant. IMPLICATIONS FOR REHABILITATION The FASH-F can be considered to be discriminant, reliable and valid for the evaluation of the severity of symptoms and sports ability in individuals with hamstring injuries. FASH-F is now a reliable and valid tool for French-speaking patients suffering from acute hamstring injury, and its application in clinical practice is particularly relevant. A limitation of our study could be that the distribution between the different study groups was not homogeneous implying that our findings may not be fully representative of the general population. [less ▲]

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See detailEmpirical Evidence on the Market Power, Business Model, Banking Stability and Performance in the Emerging Economies
Yudha Sudrajad, Oktofa; Hübner, Georges ULiege

in Eurasian Business Review (in press)

This paper studies the nexus between banks’ market power and business model represented by non-interest income and non-deposit short-term funding share. We also examine the impact of bank business model ... [more ▼]

This paper studies the nexus between banks’ market power and business model represented by non-interest income and non-deposit short-term funding share. We also examine the impact of bank business model on banking stability and performance. We use a sample made up with six ASEAN country banking sectors from 2002 to 2015. We find that banks with a strong capital base but lower net interest margin perform better in translating their market power to generate non-traditional income as alternative soruce of revenues. Our findings also show that the implementation of Basel 2 Accord encourages banks to create non-interest income from trading & derivatives activities. We also document that banks with higher market power tend to increase non-deposit short-term funding in their banking scheme. In the evaluation of the banking stability, our results suggest that banks with greater non-traditional income are associated with less banking overall risk. Moreover, non-traditional incomes also contribute to better bank performance. [less ▲]

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See detailTwo New Ur III Letters in the Louvre Museum
Colonna d'Istria, Laurent ULiege

in Rivista Degli Studi Orientali (in press)

This article provides the publication of two new Ur III letters kept at Louvre Museum. The content of these letters is concise as the majority of the Ur III administrative letters. The first one asks for ... [more ▼]

This article provides the publication of two new Ur III letters kept at Louvre Museum. The content of these letters is concise as the majority of the Ur III administrative letters. The first one asks for the return of persons before an inspection and the second letter asks for the release of one barge carrying sesame. [less ▲]

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See detailPractical guidance for engaging patients in health research, treatment guidelines and regulatory processes: results of an expert group meeting organized by the World Health Organization (WHO) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)
de Wit, M.; Cooper, Cyrus ULiege; Tugwell, P. et al

in Aging Clinical and Experimental Research (in press)

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients’ needs. However, there is currently little ... [more ▼]

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients’ needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Through a structured, collaborative process the group generated practical guidance to facilitate optimal patient engagement in clinical development and regulatory decisions. Patient engagement is a relational process. The principles outlined in this report were based on lessons learned through applied experience and on an extensive dialogue among the expert participants. This practice guidance forms a starting point from which tailoring of the approach to suit different chronic diseases may be undertaken. © 2019, The Author(s). [less ▲]

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See detailMeasuring impulsivity in Children: Adaptation and Validation of a Short Version of the UPPS-P Impulsive Behaviors Scale in Children and Investigation of Its Links with ADHD
Geurten, Marie ULiege; Catale, Corinne ULiege; Gay, Philippe et al

in Journal of Attention Disorders (in press)

Objective: Impulsivity is a multifaceted construct known to play a crucial role in the development and maintenance of a wide range of problematic behaviors and psychological disorders in children. Method ... [more ▼]

Objective: Impulsivity is a multifaceted construct known to play a crucial role in the development and maintenance of a wide range of problematic behaviors and psychological disorders in children. Method: In this study, we adapted the short French adult version of the UPPS-P Impulsive Behavior Scale for use with children (short UPPS-P-C) and tested its psychometric properties. Results: Confirmatory factor analyses conducted on a sample of 425 children (aged from 8 to 14 years) supported the five-factor structure of the scale. Additional analyses emphasized the good internal and test-retest reliability of the short UPPS-P-C. Furthermore, our results also revealed that lack of premeditation and urgency subscales were able to discriminate between children diagnosed with attention-deficit/hyperactivity disorder (ADHD) and their matched controls. Conclusion: These results suggest that the short UPPS-P-C may be considered as a promising time-saving tool to assess impulsivity traits in healthy children and in children with psychiatric disorders. [less ▲]

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See detailPathways of running away among Belgian youth
Glowacz, Fabienne ULiege; Léonard, Julie; Courtain, Audrey ULiege

in Youth and Society (in press)

Runaway behaviors among teenagers have been studied for some 40 years. Still, because runaway and homeless youths have often been confounded, little is known about what really defines a runaway adolescent ... [more ▼]

Runaway behaviors among teenagers have been studied for some 40 years. Still, because runaway and homeless youths have often been confounded, little is known about what really defines a runaway adolescent. This study targets three objectives in a mixed-method design relying on data from official files and interviews: the descriptions of teenagers reported as missing (e.g., age, sex, runaway duration and reiteration, place left behind, type of caller reporting the child as missing, motivation for closing the file) and the understanding of runaway pathways and dynamics. These studies can contribute to prevention and intervention programs by providing new perspectives on how runaway experiences should be understood in light of the adolescent process. [less ▲]

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See detailLa question de l’éducation : aiguillon des philosophies politiques. Castoriadis/Rancière.
Wustefeld, Sophie ULiege

in MethIS: Méthodes et Interdisciplinarité en Sciences Humaines (in press)

La démocratie reste un thème chéri par la philosophie politique contemporaine, pour l’écart entre ses théories et ses pratiques, pour la distance critique que ses théories offrent vis-à-vis des régimes ... [more ▼]

La démocratie reste un thème chéri par la philosophie politique contemporaine, pour l’écart entre ses théories et ses pratiques, pour la distance critique que ses théories offrent vis-à-vis des régimes démocratiques et de leur évolution, mais aussi parce qu’elle est un objet perpétuel de dissensus entre philosophes, au sujet duquel toute prétention à la véridiction est suspendue à sa réalisation pratique. À ce titre, la transmission de la volonté démocratique est un topos houleux de la philosophie politique contemporaine. Cette question catalyse les concepts pivots des philosophies politiques, la leur poser permet de mieux saisir les enjeux rivaux derrière une terminologie commune à plusieurs auteurs. C’est dans cette démarche que je vous propose d’examiner en miroir les philosophies de Cornélius Castoriadis et de Jacques Rancière. De plus en plus nombreux, des commentateurs rapprochent leurs pensées , qui peuvent s’appuyer sur plusieurs points communs : un attachement au concept de démocratie brandit contre les régimes parlementaires, une opposition contemporaine (quoique depuis des héritages différents) aux thèses défendues par Althusser, et une proximité de sources d’inspirations : la philosophie, le marxisme, et la psychanalyse. Partant de la manière dont cette proximité s’exprime dans la disjonction que chacun opère entre démocratie et science, je tenterai de discerner comment les inflexions qu’ils impriment aux concepts de volonté et d’égalité sous la guise des enjeux de la transmission dessinent des horizons politiques distincts, et dénotent des compréhensions antithétiques – mais indécidables dans la théorie – de ce que peut être la démocratie. [less ▲]

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See detailProposal of a new tDCS safety screening tool TSST (Transcranial direct current stimulation Safety Screening Tool)
Bornheim, Stephen ULiege; Croisier, Jean-Louis ULiege; Maquet, Pierre ULiege et al

in American Journal of Physical Medicine and Rehabilitation (in press)

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See detailLes Trois Trois Petits Cochons et le Grand Méchant Loup. La rencontre de deux archétypes
Jousten, Lison ULiege

in La revue des lettres modernes (in press)

Image de la menace par excellence, le Grand Méchant Loup est un adversaire dont on ne compte plus les apparitions, notamment dans les fictions destinées au jeune public. Dans Les Trois Petits Cochons, qui ... [more ▼]

Image de la menace par excellence, le Grand Méchant Loup est un adversaire dont on ne compte plus les apparitions, notamment dans les fictions destinées au jeune public. Dans Les Trois Petits Cochons, qui s’impose comme cas d’école parmi ces récits où surgit l’animal redouté, le loup devient l’ennemi du cochon, une créature traditionnellement associée à l’enfance. Ce tandem, qui repose sur un principe général d’opposition, brasse avec lui une série de représentations qui transparaissent en filigrane. Le détour opéré par l’histoire culturelle du cochon et quelques-uns de ses prolongements cinématographiques permet de dessiner progressivement les contours de la place occupée par le loup dans ce conte. [less ▲]

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See detailIndependent recollection/familiarity ratings can dissociate: Evidence from the effects of test context on recognition of event details
Willems, Sylvie ULiege; Schroyen, Sarah ULiege; Dehon, Hedwige ULiege et al

in Canadian Journal of Experimental Psychology (in press)

Bodner and Richardson-Champion (2007) found a dissociative effect of test context on binary remember/know judgments about a critical set of details from a film sequence. Details of medium difficulty were ... [more ▼]

Bodner and Richardson-Champion (2007) found a dissociative effect of test context on binary remember/know judgments about a critical set of details from a film sequence. Details of medium difficulty were more likely to be judged “recollected” when preceded by a set of difficult details than a set of easy details, but were similarly likely to be judged “familiar”. Using the same paradigm, we replicated this dissociation when participants independently rated recollection and familiarity. Our finding represents the first evidence that independent recollection/familiarity ratings can be dissociated. In contrast, previous studies using independent ratings have yielded parallel effects of variables that produce dissociative effects with binary judgments. Our discussion considers potential causes of this dissociation, whether test context influenced discrimination or response bias, and implications for interpreting subjective recognition experiences. Demonstrations that test context can affect recollection reports also have implications for designing and conducting eyewitness interviews. [less ▲]

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See detailγ Doradus stars as test of angular momentum transport models
Ouazzani, R-M; Marques, J P; Goupil, M-J et al

in Astronomy and Astrophysics (in press)

Helioseismology and asteroseismology of red giant stars have shown that the distribution of angular momentum in stellar interiors, and its evolution with time remains an open issue in stellar physics ... [more ▼]

Helioseismology and asteroseismology of red giant stars have shown that the distribution of angular momentum in stellar interiors, and its evolution with time remains an open issue in stellar physics. Owing to the unprecedented quality of Kepler photometry, we are able to seismically infer internal rotation rates in γDoradus stars, which provide the MS counterpart to the red-giants puzzle. We confront these internal rotation rates to stellar evolution models with rotationally induced transport of angular momentum, in order to test angular momentum transport mechanisms. We used a stellar model-independent method developed by Christophe et al. in order to obtain seismically inferred, buoyancy radii and near-core rotation for 37 γ Doradus stars observed by Kepler. We show that the buoyancy radius can be used as a reliable evolution indicator for field stars on the MS. We computed rotating evolutionary models including transport of angular momentum in radiative zones, following Zahn and Maeder, with the CESTAM code. This code calculates the rotational history of stars from the birth line to the tip of the RGB. The initial angular momentum content has to be set initially, which is done by fitting rotation periods in young stellar clusters. We show a clear disagreement between the near-core rotation rates measured in the sample and the rotation rates obtained from evolutionary models including rotationally induced transport following Zahn (1992). These results show a disagreement similar to that of the Sun and red giant stars. This suggests the existence of missing mechanisms responsible for the braking of the core before and along the MS. The efficiency of the missing mechanisms is investigated. The transport of angular momentum as formalized by Zahn and Maeder cannot explain the measurements of near-core rotation in main-sequence intermediate-mass stars we have at hand. [less ▲]

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See detailLa tradition manuscrite de la « Post-Vulgate ». Histoire d’une diaspora textuelle
Morato, Nicola ULiege

in Revue de Linguistique Romane (in press)

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See detailProcedural generation of flood-sensitive urban layouts
Mustafa, Ahmed Mohamed El Saeid ULiege; Zhang, Xiao Wei; Aliaga et al

in Environment and Planning B: Urban Analytics and City Science (in press)

Aside from modeling geometric shape, three-dimensional (3D) urban procedural modeling has shown its value in understanding, predicting and/or controlling effects of shape on design and urban planning. In ... [more ▼]

Aside from modeling geometric shape, three-dimensional (3D) urban procedural modeling has shown its value in understanding, predicting and/or controlling effects of shape on design and urban planning. In this paper, instead of the construction of flood resistant measures, we create a procedural generation system for designing urban layouts that passively reduce water depth during a flooding scenario. Our tool enables exploring designs that passively lower flood depth everywhere or mostly in chosen key areas. Our approach tightly integrates a hydraulic model and a parameterized urban generation system with an optimization engine so as to find the least cost modification to an initial urban layout design. Further, due to the computational cost of a fluid simulation, we train neural networks to assist with accelerating the design process. We have applied our system to several real-world locations and have obtained improved 3D urban models in just a few seconds. [less ▲]

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See detailDevelopment of specific tests in bike-trials riders and relationship with jumping ability
Thomas, Pierre-Charles; Miny, Kévin ULiege; Jidovtseff, Boris ULiege

in Science et Sports (in press)

Aims of the study - The first aim of this study was to set a battery of field tests in order to assess specific muscular function of biketrial riders. The second aim was to investigate the discrimination ... [more ▼]

Aims of the study - The first aim of this study was to set a battery of field tests in order to assess specific muscular function of biketrial riders. The second aim was to investigate the discrimination of these tests by comparing the performance of elite and amateur riders. Material and method - Twenty ELITE biketrial riders and 13 biketrial amateurs (AMAT) underwent field tests. The battery of field tests consisted in four non specific jumping tests (SJ, CMJ,SBJ and Reactivity) and three original specific tests on the bike (bike gap, side-hop over an elastic and holding time on the back-wheel). All the tests were performed on the field with portable equipment. Results – The results show that bike specific tests are very discriminant: ELITE riders were significantly superior in each test (p<0.001) The 20in riders seem to have a greater jumping ability in comparison with the 24in riders. The correlation between the jumping field tests and the bike specific tests is fairly high (r>0.7). Conclusion – The field tests as well as the bike specific tests showed to be selective and discriminant for the biketrial rider’s. Jumping ability appears to be very important in order to achieve the elite level. [less ▲]

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See detailConsequence of past anthropogenic forest fragmentation on the genetic structure of European mammals: the example of the edible dormouse (Glis glis)
Michaux, Johan ULiege; Hurner, H.; Krystufek, B et al

in Biological Journal of the Linnean Society (in press)

The genetic structure of forest animal species may allow the spatial dynamics of the forests themselves to be tracked. Two scales of change are commonly discussed: changes in forest distribution during ... [more ▼]

The genetic structure of forest animal species may allow the spatial dynamics of the forests themselves to be tracked. Two scales of change are commonly discussed: changes in forest distribution during the Quaternary, due to glacial/ interglacial cycles, and current fragmentation related to habitat destruction. However, anthropogenic changes in forest distribution may have started well before the Quaternary, causing fragmentation at an intermediate time scale that is seldom considered. To explore the relative role of these processes, the genetic structure of a forest species with narrow ecological preferences, the edible dormouse (Glis glis), was investigated in a set of samples covering a large part of its Palaearctic distribution. Strong and complex geographical structure was revealed from the use of microsatellite markers. This structure suggests that fragmentation occurred in several steps, progressively splitting the ancestral population into peripheral isolated ones. The fact that this structure postdates post-glacial recolonization, together with dating based on microsatellite data, supports the hypothesis that the differentiation was recent, starting around 9000 years ago, and took place stepwise, possibly up to Medieval times. This complements a classic phylogeographical interpretation based on the effect of past climate change, and supports the role of anthropogenic deforestation as a trigger of recent intraspecific differentiation. [less ▲]

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See detailLes troubles du sommeil chez l'enfant autiste, quel rôle pour le pédopsychiatre?
Abate Ekollo, Joëlle; Malchair, Alain ULiege

in Acta Psychiatrica Belgica (in press)

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants ... [more ▼]

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants souffrant de troubles du spectre autistique présentent un déficit de sommeil, qui peut durer jusqu’à l’adolescence. Les troubles du spectre autistique comportent des comorbidités multiples, dont des altérations du sommeil. Ils sont importants à caractériser dans cette population, car ils peuvent avoir un impact négatif sur les comportements diurnes. Par ailleurs, ils entrainent souvent des difficultés au sein de la famille. La prise en charge doit avant tout prendre en compte le contexte environnemental afin d’améliorer les habitudes et l’hygiène du sommeil. Des questionnaires ainsi que des agendas de sommeil ont été remplis par des parents afin de démontrer l’importance d’une évaluation et d’une prise en compte des troubles du sommeil chez les enfants souffrant d’autisme en consultation pédopsychiatrique. [less ▲]

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See detailThe role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves: from field observations to toxicokinetics.
Valgaeren, Bonnie; Theron, Leonard; Croubels, Siska et al

in Archives of Toxicology (in press)

A clinical case in Belgium demonstrated that feeding a feed concentrate containing considerable levels of deoxynivalenol (DON, 1.13 mg/kg feed) induced severe liver failure in 2- to 3-month-old beef ... [more ▼]

A clinical case in Belgium demonstrated that feeding a feed concentrate containing considerable levels of deoxynivalenol (DON, 1.13 mg/kg feed) induced severe liver failure in 2- to 3-month-old beef calves. Symptoms disappeared by replacing the highly contaminated corn and by stimulating ruminal development via roughage administration. A multi-mycotoxin contamination was demonstrated in feed samples collected at 15 different veal farms in Belgium. DON was most prevalent, contaminating 80% of the roughage samples (mixed straw and maize silage; average concentration in positives: 637 +/- 621 microg/kg, max. 1818 microg/kg), and all feed concentrate samples (411 +/- 156 microg/kg, max. 693 microg/kg). In order to evaluate the impact of roughage provision and its associated ruminal development on the gastro-intestinal absorption and biodegradation of DON and its acetylated derivatives (3- and 15-ADON) in calves, a toxicokinetic study was performed with two ruminating and two non-ruminating male calves. Animals received in succession a bolus of DON (120 microg/kg bodyweight (BW)), 15-ADON (50 microg/kg BW), and 3-ADON (25 microg/kg) by intravenous (IV) injection or per os (PO) in a cross-over design. The absolute oral bioavailability of DON was much higher in non-ruminating calves (50.7 +/- 33.0%) compared to ruminating calves (4.1 +/- 4.5%). Immediately following exposure, 3- and 15-ADON were hydrolysed to DON in ruminating calves. DON and its acetylated metabolites were mainly metabolized to DON-3-glucuronide, however, also small amounts of DON-15-glucuronide were detected in urine. DON degradation to deepoxy-DON (DOM-1) was only observed to a relevant extent in ruminating calves. Consequently, toxicity of DON in calves is closely related to roughage provision and the associated stage of ruminal development. [less ▲]

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See detailIPCAPS: an R package for iterative pruning to capture population structure
Chaichoompu, Kridsadakorn ULiege; Abegaz Yazew, Fentaw; Tongsima, Sissades et al

in Source Code for Biology and Medicine (in press)

Resolving population genetic structure is challenging, especially when dealing with closely related populations. Although Principal Component Analysis (PCA)-based methods and genomic var- iation with ... [more ▼]

Resolving population genetic structure is challenging, especially when dealing with closely related populations. Although Principal Component Analysis (PCA)-based methods and genomic var- iation with single nucleotide polymorphisms (SNPs) are widely used to describe shared genetic an- cestry, improvements can be made targeting fine-level population structure. This work presents an R package called IPCAPS, which uses SNP information for resolving possibly fine-level population structure. The IPCAPS routines are built on the iterative pruning Principal Component Analysis (ipP- CA) framework to systematically assign individuals to genetically similar subgroups. Our tool is able to detect and eliminate outliers in each iteration to avoid misclassification. It can be extended to de- tect subtle subgrouping in patients as well. In addition, IPCAPS supports different measurement scales for variables used to identify substructure. Hence, panels of gene expression and methylation data can be accommodated. [less ▲]

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See detailConstruction cognitive d’un motif : cooccurrences textuelles et associations mémorielles
Longrée, Dominique ULiege; Mellet, Sylvie; Lavigne, Frederic

in CogniTextes (in press)

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See detailTiwouh: an enriched technology-based solution for communication interventions
Fage, Charles ULiege; Giblet, Sarah ULiege; Jaspard, Marie et al

in Association for the Advancement of Modelling and Simulation Techniques in Enterprises (in press)

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See detailLa notion de travailleur en droit européen de la libre prestation de services et de la liberté d'établissement : Lawrie-Blum comme horizon indépassable? Examen de la jurisprudence récente de la Cour de Justice
Février, Vincent ULiege

in Revue de la Faculté de Droit de l'Université de Liège (in press), 2019/2

The concept of worker is used in European Union Law to make a distinction between the scope of application of the freedom of establishment and the freedom to provide services on one hand and the free ... [more ▼]

The concept of worker is used in European Union Law to make a distinction between the scope of application of the freedom of establishment and the freedom to provide services on one hand and the free movement of workers on the other hand. A first definition of this concept was given by the Court of Justice of the European Union in the Lawrie-Blum case. However, some cases, like Jany and Van Der Steen, deviate quite strongly from Lawrie-Blum. The aim of this article is to analyse the case law of the Court given between 2013 and 2018 in order to determine if the aforementioned arrests are isolated or not. [less ▲]

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See detailExploration of relationship between parental distress, family functioning and post-traumatic symptoms in children
Gallo, Alicia ULiege; Wertz, Céline ULiege; Kairis, Sophie et al

in European Journal of Trauma and Dissociation (in press)

We investigated the links between peritraumatic distress in children and in their parents following a potentially traumatic event, focusing specifically on the role that parents and family functioning can ... [more ▼]

We investigated the links between peritraumatic distress in children and in their parents following a potentially traumatic event, focusing specifically on the role that parents and family functioning can play in the development and maintenance of post-traumatic disorders in children. To this end, we examined a population of 41 children (aged 8 and above), and their parents, who had been admitted to the emergency room of a pediatric hospital due to an accident. The design included a two-step assessment: immediate reactions (in the hours following the event) and delayed reactions (5-8 weeks after the event). We used six questionnaires to assess reactions. The results indicated a statistically significant positive correlation between the intensity of the peri-traumatic distress of the parents and the level of post-traumatic symptoms observed later (5 to 8 weeks after the event) in the questionnaires administered to the children. Regarding educational practices, differences appear to be linked to maternal education practice and to the severity of child’s symptomatology. Finally, a link has been established between changes within the family dynamic after a potentially traumatic event and the severity of child’s post traumatic symptoms. This study showed the extent to which the parents’ initial reactions can be decisive in the outcome for a child who has experienced a potentially traumatic event. The study highlights the importance of assessing parental responses as well as paying attention to the children when they arrive in a pediatric emergency room. The results are relevant for prevention and treatment of PTSD in children, as the integration of this parental dimension early on in the process may lead to improved identification of which young patients are at risk of developing post-traumatic symptomatology. [less ▲]

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See detailPost-remission strategies for the prevention of relapse following allogeneic hematopoietic cell transplantation for high-risk acute myeloid leukemia: expert review from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Lee, C. J.; Savani, B. N.; Mohty, M. et al

in Bone Marrow Transplantation (in press)

Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy generally associated with poor prognosis. Allogeneic hematopoietic cell transplantation (alloHCT) continues to be the most potent ... [more ▼]

Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy generally associated with poor prognosis. Allogeneic hematopoietic cell transplantation (alloHCT) continues to be the most potent anti-leukemia treatment for adult patients with intermediate and high-risk AML. However, disease relapse after alloHCT remains unacceptably high and is the primary cause of treatment failure and mortality following alloHCT. It is therefore that post-transplant early cellular or pharmacologic maintenance or preemptive strategies to enhance the graft-versus-leukemia effect or to eradicate persistent minimal residual disease have been of renewed interest, particularly with the availability of more sensitive technologies to measure residual AML. Although preliminary studies have demonstrated improved outcomes with the use of post-alloHCT remission therapies, prospective randomized trials are required to determine their clinical efficacy and role in the treatment of AML. On behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we summarize the available evidence on the use and efficacy of available pharmacologic post-remission therapies, including hypomethylating agents, deacetylase inhibitors, and tyrosine kinase inhibitors, as well as cellular therapies, including preemptive and prophylactic donor lymphocyte infusions for the prevention of relapse of AML. © 2018, Springer Nature Limited. [less ▲]

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See detailPer una edizione integrale e analitica dell'incipit della Storia d'Italia di Francesco Guicciardini
Moreno, Paola ULiege

in Laboratoire Italien: Politique et Société (in press)

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See detailA situated expert judgment: QSAR models and transparency in the European regulation of chemicals
Thoreau, François ULiege; Laurent, Brice

in Science & Technology Studies (in press)

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See detailIntravenous lipid emulsions in paediatric patients
Lapillonne, A; Didler Mis, N; Goulet et al

in Clinical Nutrition (in press)

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See detailCrises
Dechene, Antoine ULiege; Dupont, Bruno ULiege

in MethIS: Méthodes et Interdisciplinarité en Sciences Humaines (in press)

« Crises » fût la deuxième journée d’étude organisée par Intersections, groupe interuniversitaire de jeunes chercheuses et chercheurs en sciences humaines basé à l’Université de Liège. Cette journée ... [more ▼]

« Crises » fût la deuxième journée d’étude organisée par Intersections, groupe interuniversitaire de jeunes chercheuses et chercheurs en sciences humaines basé à l’Université de Liège. Cette journée visait à rassembler un maximum de points de vue sur une thématique commune : la notion de « crise ». Celle-ci semblait particulièrement adaptée, car elle se situe au carrefour de nombreuses disciplines (domaine médical, juridico-politique, théologique, économique, mais aussi linguistique, historique et littéraire). L’emploi du terme crise a beaucoup varié suivant les époques et les usages langagiers. Aujourd’hui, il est à la fois utilisé de façon abstraite, comme un mot courant et passe-partout, mais également de manière très précise en fonction de la discipline ou du contexte dans lequel il est employé. Cette introduction, ainsi que les articles qui la suivent, offrent une multitude de perspectives révélant la crise comme l’ « intersection » qui permet l’activité critique. Son caractère interdisciplinaire est propice à la confrontation d’idées et est à la base de ces articles qui tenteront de mieux cerner la polysémie inhérente au concept, dont la forme plurielle semble être la plus adéquate : crises. [less ▲]

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See detailRôle et langue de Tchantchès dans les représentations en castelets des romans de chevalerie : le cas des Quatre fils Aymon
Baiwir, Esther ULiege; Impe, Anaëlle

in Enquêtes du Musée de la Vie Wallonne (in press)

Pourquoi et dans quelle mesure les montreurs de marionnettes liégeoises font-ils intervenir Tchantchès aux côtés des grands chevaliers médiévaux, dont les aventures constituent une part importante du ... [more ▼]

Pourquoi et dans quelle mesure les montreurs de marionnettes liégeoises font-ils intervenir Tchantchès aux côtés des grands chevaliers médiévaux, dont les aventures constituent une part importante du répertoire liégeois ? Quels sont ses moyens d'action, mais également ses modes d'expression ? Divers registres de langue apparaissent au fil des spectacles ; quels sont ceux prêtés à notre héros ? Et surtout, ce rôle et cette langue ont-ils évolué au fil du temps ? C’est à ces quelques questions que nous tentons de répondre, en observant les différentes interventions de Tchantchès dans les réécritures des aventures des quatre fils Aymon, l’une des œuvres les plus anciennes et les plus fréquemment jouées dans les théâtres liégeois dévolus aux comédiens de bois. [less ▲]

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See detailRiver habitat homogenisation enhances trophic competition and promotes individual specialisation among young of the year fish
Latli, Adrien; Michel, Loïc ULiege; Lepoint, Gilles ULiege et al

in Freshwater Biology (in press)

In large rivers, the success of ontogenic development of fish is mainly influenced by resource availability and by the possibility of species to adapt their diet (i.e. trophic niche). Human have ... [more ▼]

In large rivers, the success of ontogenic development of fish is mainly influenced by resource availability and by the possibility of species to adapt their diet (i.e. trophic niche). Human have drastically modified freshwater habitats, notably for navigation purposes. Such modifications may drastically affect food availability for young of the year (YOY) fish and, consequently, influence their ability to reach the adult age. In the River Meuse, a decrease of fish abundance is thought to be linked to a drastic decrease of phytoplankton biomass. In this context of lowering phytoplankton biomass, we quantified the trophic niches of three cyprinid species (common bleak Alburnus alburnus, chub Squalius cephalus, and roach Rutilus rutilus) and one percid species (European perch Perca fluviatilis) at various stages of development, in order to estimate the influence of river channelization in the intra and interspecific competitions. It was done using stable isotope analysis in two reaches of the River Meuse differing by their degree of regulation. We hypothesized that habitat heterogeneity increases YOY abundance over time by offering more alternative resources which reduce food competition, notably during the early period of life. Our study provides evidence that the River Meuse flow and depth regulation significantly impacted the abundance and taxonomic diversity of YOY. In the context of low planktonic biomass, most YOY relied on benthic food sources. In the heavily channelized reach, between-stages competition and low resource diversity increased the diet partition between cyprinid larvae and forced a part of individuals to consume non-optimal energetic food sources such as aquatic vegetation. On the other hand, in the less channelized reach, larvae displayed a generalist feeding habit focusing on energetic prey such as different taxa of macroinvertebrates, suggesting that the diversity of habitat reduces the food competition within and between stages and the predation risk. Developing a sustainable and integrated river management may be useful for protecting biodiversity and restoring ecosystem function, in order to improve the ecological potential of regulated rivers. [less ▲]

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See detailEvaluation of mandibular and medial retropharyngeal lymph nodes in the staging of dogs with oral malignant melanoma and squamous cell carcinoma
Grimes, Janet; Mestrinho, Lisa; Berg, John et al

in Journal of the American Veterinary Medical Association (in press)

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See detailLes critiques chrétiennes des lectisternes et sellisternes romains : un banquet trop anthropomorphe ?
Berthelet, Yann ULiege

in Les Cahiers du CEDOPAL (in press)

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See detailL’activité éditoriale comme démarche de représentation de la connaissance: l’exemple de la ponctuation médiévale
Mazziotta, Nicolas ULiege

in Diachroniques: Revue de linguistique française diachronique (in press)

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See detailInfluence de la fatigue sur les paramètres biomécaniques de la foulée mesurés par accéléromètrie
Jidovtseff, Boris ULiege; RODRIGUEZ DE LA CRUZ, Carlos ULiege; Bury, Thierry ULiege et al

in Science et Sports (in press)

Aims of the study The aim of the study was to investigate the influence of fatigue on stride biomechanics measured by a portable accelerometer, the MyotestRun. Opportunities of the protocol allowed ... [more ▼]

Aims of the study The aim of the study was to investigate the influence of fatigue on stride biomechanics measured by a portable accelerometer, the MyotestRun. Opportunities of the protocol allowed additional analysis on the device reliability and sensitivity. Methods Thirty-two male subjects, divided in two groups (runners and control), were involved in the study and achieved a treadmill progressive VO2max test; repeated run at constant velocity on a track and a field test at 90% of the VvO2max until exhaustion. The biomechanical measurements obtained from the MyotestRun allow exploring the reliability, the influence of speed, the differences between treadmill and track stride and the influence of fatigue. Results Results show an excellent reproducibility of the MyotestRun values, except for the asymmetry of the stride. No significant stride difference appears between treadmill and track conditions. The progressive test shows that all the parameters evolve with speed increment, confirming the sensitivity of the MyotestRun. The study shows changes in the stride with the fatigue, such as an increase of the contact time, a decrease of the force. However any change in the stride frequency is observed. If the study shows that the fatigue pattern is more constant in the runners group it also highlights adaptations to fatigue that can be very different from one subject to another. Conclusion This study confirmed that MyotestRun is a useful device in the stride analysis. The influence of fatigue on the stride is in accordance with most of the studies while confirming very important interindividual differences. [less ▲]

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See detailL’Église des Piémontais à Rome au début du XVIIe siècle. Les “musiques extraordinaires” d’une nation composite
Morales, Jorge ULiege

in Revue Belge de Musicologie (in press), 73

Cet article présente les premiers résultats des recherches archivistiques sur la vie musicale de l’Église nationale des Piémontais à Rome. La construction de cette église va de pair avec la construction ... [more ▼]

Cet article présente les premiers résultats des recherches archivistiques sur la vie musicale de l’Église nationale des Piémontais à Rome. La construction de cette église va de pair avec la construction de l’identité et l’affirmation politique d’un duché qui, de « territoire tampon, devient un État intermédiaire » . Cette contribution permet d’examiner les transferts de sacralité qui s’opèrent entre le duché de Piémont-Savoie et la Ville éternelle, la manière dont cette église devient le théâtre de l’affirmation politique et sociale de la famille de Savoie, mais également la circulation des musiciens locaux et venus d’ailleurs qui font de l’église de la nation piémontaise un laboratoire de l’identité savoyarde à Rome. [less ▲]

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See detailMatérialisme et révolution chez Célestin Freinet
Janvier, Antoine ULiege

in Cahiers du GRM (in press)

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See detailAbaloparatide for risk reduction of nonvertebral and vertebral fractures in postmenopausal women with osteoporosis: a network meta-analysis
Reginster, Jean-Yves ULiege; Bianic, F.; Campbell, R. et al

in Osteoporosis International (in press)

Summary: This network meta-analysis assessed the efficacy of abaloparatide versus other treatment options to reduce the risk of fractures in women with postmenopausal osteoporosis. The analysis indicates ... [more ▼]

Summary: This network meta-analysis assessed the efficacy of abaloparatide versus other treatment options to reduce the risk of fractures in women with postmenopausal osteoporosis. The analysis indicates that abaloparatide reduces the risk of fractures in women with postmenopausal osteoporosis versus placebo and compared with other treatment options. Introduction: This network meta-analysis (NMA) assessed the relative efficacy of abaloparatide versus other treatments to reduce the risk of fractures in women with postmenopausal osteoporosis (PMO). Methods: PubMed®, Embase®, and the Cochrane Central Register of Controlled Trials were searched for randomized controlled trials published before December 20, 2017, that included women with PMO who were eligible to receive interventions for primary or secondary fracture prevention. The NMA was conducted by fracture site (vertebral [VF], nonvertebral [NVF], and wrist), with the relative risk (RR) of fracture versus placebo the main clinical endpoint. The NMA used fixed-effects and random-effects approaches. Results: A total of 4978 articles were screened, of which 22 were included in the analysis. Compared with other treatments, abaloparatide demonstrated the greatest treatment effect relative to placebo in the VF network (RR = 0.13; 95% credible interval [CrI] 0.04–0.34), the NVF network (RR = 0.50; 95% CrI 0.28–0.85), and the wrist fracture network (RR = 0.39; CrI 0.15–0.90). Treatment ranking showed that abaloparatide had the highest estimated probability of preventing fractures in each of the networks (79% for VF, 70% for NVF, and 53% for wrist fracture) compared with other treatments. Individual networks demonstrated a good level of agreement with direct trial evidence and direct pair-wise comparisons. Conclusions: This NMA indicates that abaloparatide reduces the RR of VF, NVF, and wrist fracture in women with PMO with or without prior fracture versus placebo, compared with other treatment options. Limitations include that adverse events and drug costs were not considered, and that generalizability is limited to the trial populations and endpoints included in the NMA. © 2019, The Author(s). [less ▲]

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See detailEditorial
Simons, Germain ULiege; Poffé, Corentin ULiege; Beckers, Jacqueline ULiege et al

in Didactiques en Pratique (in press), 4

L'éditorial présente brièvement le n° 4 de la revue Didactiques en pratique, qui est principalement articulé autour des actes de l'Université d'été 2017 "Les tâches complexes. Apprentissage et évaluation".

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See detailLe syndrome de Klinefelter : actualités cliniques et thérapeutiques
VALDES SOCIN, Hernan Gonzalo ULiege; Rey, R; COPPENS, Luc ULiege et al

in Vaisseaux, Coeur, Poumons (in press), 24(1),

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See detailAdaptive large neighborhood search for multi-trip vehicle routing with time windows
François, Véronique ULiege; Arda, Yasemin ULiege; Crama, Yves ULiege

in Transportation Science (in press)

We consider a multi-trip vehicle routing problem with time windows (MTVRPTW), in which each vehicle can perform several trips during its working shift. This problem is especially relevant in the context ... [more ▼]

We consider a multi-trip vehicle routing problem with time windows (MTVRPTW), in which each vehicle can perform several trips during its working shift. This problem is especially relevant in the context of city logistics. Heuristic solution methods for multi-trip vehicle routing problems often separate routing and assignment phases in order to create trips and then assign them to the available vehicles. We show that this approach is outperformed by an integrated solution method in the presence of time windows. We use an automatic configuration tool to obtain efficient and contextualized implementations of our solution methods. We provide suitable instances for the MTVRPTW as well as an instance generator. Also, we discuss the relevance of two objective functions: the total duration and the total travel time. When minimizing the travel time, large increases of waiting time are incurred, which is not realistic in practice. [less ▲]

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See detailEnhanced Laplace transform and holomorphic Paley-Wiener-type theorems
Dubussy, Christophe ULiege

in Rendiconti del Seminario Matematico della Università di Padova (in press)

Starting from a remark about the computation of Kashiwara-Schapira's enhanced Laplace transform by using the Dolbeault complex of enhanced distributions, we explain how to obtain explicit holomorphic ... [more ▼]

Starting from a remark about the computation of Kashiwara-Schapira's enhanced Laplace transform by using the Dolbeault complex of enhanced distributions, we explain how to obtain explicit holomorphic Paley-Wiener-type theorems. As an example, we get back some classical theorems due to Polya and Méril as limits of tempered Laplace-isomorphisms. In particular, we show how contour integrations naturally appear in this framework. [less ▲]

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See detailLa Vigna Manzi a Garaguso (MT) : Vecchi scavi, ricerche in corso e prospettive di studio di un importante sito indigeno
Cuvelier, Graham ULiege; Morard, Thomas ULiege; Motta, Lucie

in Siris: Studi e Ticerche della Scuola di Specializzazione in Archeologia di Matera (in press)

This article traces the history of the archaeological research conducted on the site of the Vigna Manzi in Garaguso starting from the excavation of Vittorio Di Cicco in 1916 (which uncovered the famous ... [more ▼]

This article traces the history of the archaeological research conducted on the site of the Vigna Manzi in Garaguso starting from the excavation of Vittorio Di Cicco in 1916 (which uncovered the famous “Dea di Garaguso” and her tempietto) to the five surveys run by Jean-Paul Morel between 1969 and 1970. It then presents the results of the campaign led by Jean-Marc Moret in 2008 as well as the reopening and the prospects of the study of this site by the University of Liège. [less ▲]

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See detailModeling of coupled heat and mass transfer during drying of ebony wood using indirect natural convection solar dryer
Simo-Tagne, Merlin; Bonoma, B.; Bennamoun, L. et al

in Drying Technology (in press)

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See detailIntégrer le droit international au champ des relations internationales : les juristes belges à Versailles en 1919
Genin, Vincent ULiege

in Relations internationales (in press), (2),

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See detailMood Disorders Patients Treated in a Day Hospital: Focus on Changes in Alexithymia and Openness to Emotions
Triffaux, Jean-Marc ULiege; Nasello, Julian ULiege; Servais, Catherine et al

in Clinical Psychiatry (in press)

Alexithymia and Openness to Emotions (OE) are strongly linked to mood disorders. Alexithymia represents the difficulty of giving words to emotions, whilst OE refers to cognitive representation ... [more ▼]

Alexithymia and Openness to Emotions (OE) are strongly linked to mood disorders. Alexithymia represents the difficulty of giving words to emotions, whilst OE refers to cognitive representation, communication and regulation aspects of emotions. We investigated variables impacting both alexithymia and OE for mood disorder patients (N = 73), before and after a treatment period in a day psychiatric hospital. Significant score changes and, notably, significant impacts of perceived social support were expected. [less ▲]

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See detailDirect measurement of groundwater flux in aquifers within the discontinuous permafrost zone: an application of the finite volume point dilution method near Umiujaq (Nunavik, Canada)
Jamin, Pierre ULiege; Cochand, Marion; Dagenais, Sophie et al

in Hydrogeology Journal (in press)

Permafrost thaw is a complex process resulting from interactions between the atmosphere, soil, water and vegetation. Although advective heat transport by groundwater at depth likely plays a significant ... [more ▼]

Permafrost thaw is a complex process resulting from interactions between the atmosphere, soil, water and vegetation. Although advective heat transport by groundwater at depth likely plays a significant role in permafrost dynamics at many sites, there is lack of direct measurements of groundwater flow patterns and fluxes in such cold-region environments. Here, the finite volume point dilution method (FVPDM) is used to measure in-situ groundwater fluxes in two sandy aquifers in the discontinuous permafrost zone, within a small watershed near Umiujaq, Nunavik (Quebec), Canada. The FVPDM theory is first reviewed, then results from four FVPDM tests are presented: one test in a shallow supra-permafrost aquifer, and three in a deeper sub-permafrost aquifer. Apparent Darcy fluxes derived from the FVPDM tests varied from 0.5×10-5 to 1.0×10-5 m/s, implying that advective heat transport from groundwater flow could be contributing to rapid permafrost thaw at this site. In providing estimates of the Darcy fluxes at the local scale of the well screens, the approach offers more accurate and direct measurements over indirect estimates using Darcy’s law. The tests show that this method can be successfully used in remote areas and with limited resources. Recommendations for optimizing the test protocol are proposed. [less ▲]

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See detailFundamental Studies on Poly(2-oxazoline) Side Chain Isomers Using Tandem Mass Spectrometry and Ion Mobility-Mass Spectrometry
Haler, Jean ULiege; de la Rosa, Victor R.; Massonnet, Philippe ULiege et al

in Journal of the American Society for Mass Spectrometry (in press)

When polymer mixtures become increasingly complex, the conventional analysis techniques become insufficient for complete characterization. Mass spectrometric techniques can satisfy this increasing demand ... [more ▼]

When polymer mixtures become increasingly complex, the conventional analysis techniques become insufficient for complete characterization. Mass spectrometric techniques can satisfy this increasing demand for detailed sample characterization. Even though isobaric polymers are indistinguishable using simple mass spectrometry (MS) analyses, more advanced techniques such as tandem MS (MS/MS) or ion mobility (IM) can be used. Here, we report proof of concept for characterizing isomeric polymers, namely poly(2-n-propyl-2-oxazoline) (Pn-PrOx) and poly(2-isopropyl-2-oxazoline) (Pi-PrOx), using MS/MS and IM-MS. Pi-PrOx ions lose in intensity at higher accelerating voltages than Pn-PrOx ions during collision-induced dissociation (CID) MS/MS experiments. A Pn/i-PrOx mixture could also be titrated using survival yield calculations of either precursor ions or cation ejection species. IM-MS yielded shape differences in the degree of polymerization (DP) regions showing the structural rearrangements. Combined MS techniques are thus able to identify and deconvolute the molar mass distributions of the two isomers in a mixture. Finally, the MS/MS and IM-MS behaviors are compared for interpretation. [less ▲]

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See detailEnjeux politiques et critiques d'une philosophie des normes
Caeymaex, Florence ULiege; Pieron, Julien ULiege

in Dissensus (in press)

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See detailFirst geochimichal sourcing of 'Balkan flint' and 'Prut flint' from Palaeolithic Romania: potentials, limitations and future directions
Moreau, Luc; Ciornei, A.; Gjesfjelds, E. et al

in Archaeometry (in press)

Attributions of flint artefacts to specific geographical sources ideally require some form of independent validation through suitable petrographical and/or geochemical analyses, given the implications of ... [more ▼]

Attributions of flint artefacts to specific geographical sources ideally require some form of independent validation through suitable petrographical and/or geochemical analyses, given the implications of raw material transfer on interpretations of prehistoric mobility and land-use strategies. We investigated the potential to ‘fingerprint’ flint from two archaeological sites in Eastern Romania – Mitoc-Malu Galben and Bistricioara-Lutărie III, using Laser Ablation – Inductively Coupled Plasma – Mass Spectrometry (LA-ICP-MS) in combination with multivariate statistical analysis. Our results suggest that geochemical analyses do not yet have the level of resolution required to assign single artefacts to specific geographic locations in the context of Romania and Bulgaria. The mismatches of signatures between training and test data however raise new questions and open unforeseen perspectives. [less ▲]

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See detailConsensus report: Peri-implant diseases and conditions
Berglundh, Tord; Armitage, Gary; Avila-Ortiz, Gustavo et al

in Journal of Periodontology (in press)

A classification for peri-implant diseases and conditions was presented. Focused questions on the characteristics of peri-implant health, peri-implant mucositis, periimplantitis, and soft- and hard-tissue ... [more ▼]

A classification for peri-implant diseases and conditions was presented. Focused questions on the characteristics of peri-implant health, peri-implant mucositis, periimplantitis, and soft- and hard-tissue deficiencies were addressed. Peri-implant health is characterized by the absence of erythema, bleeding on probing, swelling, and suppuration. It is not possible to define a range of probing depths compatible with health; of more importance are the clinical signs of inflammation. Peri-implant health can exist around implants with reduced bone support.The main clinical characteristic of peri-implant mucositis is bleeding on gentle probing. Erythema, swelling, and/or suppuration may also be present. An increase in probing depth is often observed in the presence of peri-implant mucositis due to swelling or decrease in probing resistance. There is strong evidence from animal and human experimental studies that plaque is the etiological factor for peri-implant mucositis. Peri-implantitis is a plaque-associated pathological condition occurring in tissues around dental implants, characterized by inflammation in the peri-implant mucosa and subsequent progressive loss of supporting bone. Peri-implantitis sites exhibit clinical signs of inflammation, bleeding on probing, and/or suppuration, increased probing depths and/or recession of the mucosal margin in addition to radiographic bone loss. The evidence is equivocal regarding the effect of keratinized mucosa on the longterm health of the peri-implant tissue. It appears, however, that keratinized mucosa may have advantages regarding patient comfort and ease of plaque removal. Case definitions in day-to-day clinical practice and in epidemiological or diseasesurveillance studies for peri-implant health, peri-implant mucositis, and periimplantitis were introduced. The proposed case definitions should be viewed within the context that there is no generic implant and that there are numerous implant designs with different surface characteristics, surgical and loading protocols. It is recommended that the clinician obtain baseline radiographic and probing measurements following the completion of the implant-supported prosthesis. [less ▲]

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See detailSimultaneous production of two kinds of sounds in relation with sonic mechanism in the boxfsh Ostracion meleagris and O. cubicus
Parmentier, Eric ULiege; Solagna, Laura; Bertucci, Frédéric et al

in Scientific Reports (in press)

In fshes, sonic abilities for communication purpose usually involve a single mechanism. We describe here the sonic mechanism and sounds in two species of boxfsh, the spotted trunkfsh Ostracion meleagris ... [more ▼]

In fshes, sonic abilities for communication purpose usually involve a single mechanism. We describe here the sonic mechanism and sounds in two species of boxfsh, the spotted trunkfsh Ostracion meleagris and the yellow boxfsh Ostracion cubicus. The sonic mechanism utilizes a T-shaped swimbladder with a swimbladder fenestra and two separate sonic muscle pairs. Extrinsic vertical muscles attach to the vertebral column and the swimbladder. Perpendicularly and below these muscles, longitudinal intrinsic muscles cover the swimbladder fenestra. Sounds are exceptional since they are made of two distinct types produced in a sequence. In both species, humming sounds consist of long series (up to 45s) of hundreds of regular low-amplitude pulses. Hums are often interspersed with irregular click sounds with an amplitude that is ten times greater in O. meleagris and forty times greater in O. cubicus. There is no relationship between fsh size and many acoustic characteristics because muscle contraction rate dictates the fundamental frequency. We suggest that hums and clicks are produced by either separate muscles or by a combination of the two. The mechanism complexity supports an investment of boxfsh in this communication channel and underline sounds as having important functions in their way of life. [less ▲]

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See detailLe lettere bipartite e i discorsi politici di Francesco Guicciardini nell’anno 1525
Miesse, Hélène ULiege

in Giornale Storico della Letteratura Italiana (in press)

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See detailMitigation Techniques for Nappe Oscillations on Free-Overfall Structures
Lodomez, Maurine ULiege; Crookston, Brian ULiege; Tullis, Blake et al

in Civil Engineering ASCE (in press)

Nappe oscillation is a phenomenon that can have an undesirable impact to the local environmental (e.g., nearby residences, parks) as the phenomenon has been observed to produce a significant level of ... [more ▼]

Nappe oscillation is a phenomenon that can have an undesirable impact to the local environmental (e.g., nearby residences, parks) as the phenomenon has been observed to produce a significant level of noise caused by acoustic pressure waves. As a result, a detailed investigation was undertaken to identify practical and effective mitigation solutions to address these effects for free-overfall structures. Nappe oscillations were studied using a prototype-scale linear weir (weir length of 3.5 m and fall height of 3 m), a high-speed camera, and audio equipment. The effectiveness of various crest modifications to reduce nappe oscillation and any corresponding impacts to hydraulic efficiency were evaluated. The test matrix included the optimization (position and spacing of elements) of three mitigation solutions: 12 configurations with projecting elements, 5 configurations with deflectors and one configuration with a step. These three countermeasures proved to be effective after the optimization of their characteristics. In particular, deflectors or a step produced the maximum noise reduction while decreasing the discharge coefficient by less than 3 % over the range of experimental conditions. [less ▲]

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See detailCommon Clays of Foumban area (West Cameroon): Variability, Distribution, Characterization and Potential Applications
Nkalih Mefire, Abiba ULiege; YONGUE, Rose Fouateu

in Journal of African Earth Sciences (in press)

Common clay deposits from five localities in Foumban (West Cameroon) were investigated for their morphological, mineralogical and geochemical properties to determine their potential source rocks and ... [more ▼]

Common clay deposits from five localities in Foumban (West Cameroon) were investigated for their morphological, mineralogical and geochemical properties to determine their potential source rocks and suitability in ceramic product. The analytical results were obtained by X-ray diffraction, X-ray fluorescence spectrometry, Thermogravimetric Analysis, Scanning Electron Microscopy, and Fourier Transform Infrared Spectrometry. Morphologically, an homogeneous clayey layer was found in the upper part of a laterite cover on interfluves, and a clayey heterogeneous hydromorphic material in valleys. They are minerallogically composed of kaolinite (25-84%), illite (0-18%), smectite (0- 31%), and chlorite (0-8 %), associated with quartz (2-44 %), K-feldspars (0-27 %.), plagioclase (0-26%), goethite; (0-9%) with traces of rutile and hematite (≤5 %). The geochemical analysis shows a 115 relative large amount of SiO2 (45-71%), Al2O3 (14-31%), and low Fe2O3 (up to 11 %) suggesting weathering of mainly granitic and rhyolitic parent rocks. Most studied clays could be applied to building ceramic product such as bricks (refractory or not) and tiles. Illite may promote the glassy phase responsible for the densification of the final product. In addition, the relatively high proportion of alkali elements (K2O + Na2O, 6-8%) in some samples from Marom, Koutaba and is responsible for low firing temperature. However the presence of smectite (up to 5 %) limits the application of some Koutaba and Marom clays for ceramic building. The high Fe2O3 contents (> 8 %) in some Bangourain clays implied some pretreatment. [less ▲]

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See detailCompte-rendu de l'ouvrage de Jacques Dürrenmatt, La ponctuation en français
Mazziotta, Nicolas ULiege

in Bulletin de la Société de Linguistique de Paris (in press)

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See detailAttitudes towards personhood in the locked-in syndrome: from third- to first- person perspective and interpersonal significance
Nizzi, Marie-Christine; Blandin, Veronique; Demertzi, Athina ULiege

in Neuroethics (in press)

Personhood is ascribed on others, such that someone who is recognized to be a person is bestowed with certain civils rights and the right to decision-making. A rising question is how severely brain ... [more ▼]

Personhood is ascribed on others, such that someone who is recognized to be a person is bestowed with certain civils rights and the right to decision-making. A rising question is how severely brain-injured patients who regain consciousness can also regain their personhood. The case of patients with locked-in syndrome (LIS) is illustrative to this matter. Upon restoration of consciousness, patients with LIS find themselves in a state of profound demolition of their bodily functions. From the third-person perspective, it can be expected that LIS patients might experience a differential personal identity and maybe lose their status of persons. However, from the patients’ standpoint, it is uncontested that they retain their personal identity and they consider themselves as persons. We here assist this perspective by including self-reports from patients with LIS aimed at identifying the primary expectations of patients for their care by non-medical professionals. Based on these first-hand reports, we argue that personhood in LIS is progressively regained as the widening circle of others recognizes them as persons. [less ▲]

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See detailExternal Quality Assessment of 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) assays.
Carter, G. D.; Ahmed, F.; Berry, J. et al

in The Journal of steroid biochemistry and molecular biology (in press)

The discovery that mutations of the CYP24A1 gene are a cause of idiopathic infantile hypercalcemia (IIH) has revived interest in measuring serum 24,25(OH)2D3. Several studies have also suggested that a ... [more ▼]

The discovery that mutations of the CYP24A1 gene are a cause of idiopathic infantile hypercalcemia (IIH) has revived interest in measuring serum 24,25(OH)2D3. Several studies have also suggested that a high 25-hydroxyvitamin D3(25-OHD3):24,25(OH)2D3 ratio might provide additional diagnostic information in the investigation of vitamin D deficiency. Measurement of 24,25(OH)2D3 is necessarily restricted to laboratories with mass spectrometry methods although cross reactivity of the metabolite in immunoassays for 25-OHD is a potential cause of misleading results. The international External Quality Assessment (EQA) scheme for vitamin D metabolites (DEQAS) was set up in 1989. In 2013 DEQAS became an accuracy based EQA for 25-OHD with 'target values' assigned by the National Institute of Standards and Technology (NIST) Reference Measurement Procedure (RMP). A pilot scheme for serum 24,25(OH)2D3 was started in 2015 and participants were asked to measure the metabolite on each of the 5 samples sent out for 25-OHD. Inter-laboratory agreement was poor but this may reflect methodological differences, in particular different approaches to assay standardization. An important potential contribution to reducing variability among assays was the development by NIST of a 24,25(OH)2D3 RMP and its use in assigning values to SRMs 972a, 2973 and 2971, supported by the NIH Office of Dietary Supplements (ODS) as part of the Vitamin D Standardization Program (VDSP) effort. [less ▲]

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See detailBenefits of Digital Smile Design (DSD) in the conception of a Complex Orthodontic Treatment Plan: A Proof of Concept
CHARAVET, Carole ULiege; BERNARD, Jean-Claude ULiege; GAILLARD, Cyril et al

in International Orthodontics (in press)

Introduction: Digital Smile Design (DSD) is a systematic protocol based on specific photographs and software analysis that is used worldwide. DSD aims to assist the practitioner in creating and planning a ... [more ▼]

Introduction: Digital Smile Design (DSD) is a systematic protocol based on specific photographs and software analysis that is used worldwide. DSD aims to assist the practitioner in creating and planning a course of treatment, especially in a multidisciplinary approach, and provides a virtual simulation of the final result. Additionally, it is a tool that enables communication and discussion between all the dental team, including the dental laboratory, and also with the patient. Although widely described and used in prosthetic rehabilitation, this tool remains only anecdotally used in the world of orthodontics. The objective of this proof of concept was to describe the application of the Digital Smile Design protocol in the diagnosis of orthodontic treatment. Materials and Methods: A teenage patient was referred to our university clinic by a private orthodontic practitioner for a second opinion on the treatment at that time. The patient had a self-ligating orthodontic appliance. According to the history of the case and the oral situation at that moment, the patient required an accurately calculated plan for orthodontic tooth movement that would permit the achievement of future rehabilitation. Therefore, the decision was taken to use a DSD protocol to potentially complete the classic orthodontic examination. Results: From the classic orthodontic examination, the patient presented a molar class I, midline deviations, the #21 and #23 were missing, #12 was conoid (microdontic) and, finally, #22 was in the position of #21. From the DSD results, three different views simulated the final results and therefore provided additional and relevant information, such as the correct position of the upper midline and the correct position of #12, #13, #22 and #23. Conclusion: This proof of concept showed the clinical relevance of the Digital Smile Design protocol as a new tool for complex orthodontic treatment planning, especially in a multidisciplinary approach. Further publications will be necessary in order to define a specific DSD protocol for orthodontic treatment. [less ▲]

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See detailFictions de l’œuvre. Projets et textes possibles dans les romans de la vie littéraire
Saint-Amand, Denis ULiege

in Cahiers ReMIX (in press)

Le monde des études littéraires a vu se développer, au cours de ces dernières années, une théorie des textes possibles qui confronte la réception traditionnelle des œuvres (c’est-à-dire la façon dont leur ... [more ▼]

Le monde des études littéraires a vu se développer, au cours de ces dernières années, une théorie des textes possibles qui confronte la réception traditionnelle des œuvres (c’est-à-dire la façon dont leur lecture se concrétise la plupart du temps et le commentaire qu’on en livre habituellement) à une réinvention de leur signification, tirant parti des impensés de la fiction, des non-dits, des interactions interrompues, des blancs, des inférences labiles et autres zones creuses du récit qui offrent des prises pour une renégociation herméneutique. À côté des réinventions herméneutiques des œuvres classiques, de l’approche génétique et du fantasme programmatique autour des productions perdues, la critique des textes possibles aurait tout à gagner à explorer un continent fictionnel, fructueux en termes d’œuvres en puissance et qui recèle d’indications sur l’évaluation des modes et tendances d’une époque émanant des représentations des écrivains eux-mêmes : les œuvres imaginaires qui n’existent qu’en tant qu’elles sont inscrites dans d’autres œuvres, qui en esquissent les contours, les présentent voire les citent. Celles-là sont au cœur de la présente enquête, menée à partir du corpus rassemblé dans la base de données du GREMLIN ; on interroge dans cette contribution la façon dont, par métonymie, elles contribuent à une représentation fictionnelle de la vie littéraire. [less ▲]

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See detailThe developmental neural substrates of item and serial order components of verbal working memory
Attout, Lucie ULiege; Ordonez Magro, Laura; Szmalec, Arnaud et al

in Human Brain Mapping (in press)

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See detailEvidence of freezing pressure in sea ice discrete brine inclusions and its impact on aqueous-gaseous equilibrium
Crabeck, Odile; Galley, R.J.; Mercury, L. et al

in Journal of Geophysical Research. Oceans (in press)

Sea ice in part controls surface water properties and the ocean-atmosphere exchange of greenhouse gases at high latitudes. In sea ice gas exists dissolved in brine and as air bubbles contained in liquid ... [more ▼]

Sea ice in part controls surface water properties and the ocean-atmosphere exchange of greenhouse gases at high latitudes. In sea ice gas exists dissolved in brine and as air bubbles contained in liquid brine inclusions, or as bubbles trapped directly within the ice matrix. Current research on gas dynamics within the ocean-sea ice-atmosphere interface has been based on the premise that brine with dissolved air becomes supersaturated with respect to the atmosphere during ice growth. Based on Henry’s Law, gas bubbles within brine should grow when brine reaches saturation during cooling, given that the total partial pressure of atmospheric gases is above the implicit pressure in brine of 1 atm. Using high-resolution light microscopy time series imagery of gas bubble evolution inside discrete brine pockets, we observed bubbles shrinking during cooling events in response to the development of freezing pressure above 3 atm. During warming of discrete brine pockets, existing bubbles expand and new bubbles nucleate in response to depressurization. Pressure variation within these inclusions has direct impacts on aqueous-gaseous equilibrium, indicating that Henry's Law at a constant pressure of 1 atm is inadequate to assess the partitioning between dissolved and gaseous fractions of gas in sea ice. This new evidence of pressure build-up in discrete brine inclusions controlling the solubility of gas and nucleation of bubbles in these inclusions has the potential to affect the transport pathways of air bubbles and dissolved gases within sea ice-ocean-atmosphere interface and modifies brine biochemical properties. [less ▲]

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See detailAssociation between dietary nutrient intake and sarcopenia in the SarcoPhAge study
Beaudart, Charlotte ULiege; Locquet, Médéa ULiege; Touvier, M. et al

in Aging Clinical and Experimental Research (in press)

Background: It has been suggested that a balanced nutritional intake may be useful in preventing or even reversing sarcopenia. Aim: To describe cross-sectional associations between dietary nutrient intake ... [more ▼]

Background: It has been suggested that a balanced nutritional intake may be useful in preventing or even reversing sarcopenia. Aim: To describe cross-sectional associations between dietary nutrient intake and sarcopenia. Methods: Subjects recruited from the SarcoPhAge study population completed a food frequency questionnaire. The micronutrient and macronutrient intake was evaluated in both sarcopenic and non-sarcopenic participants. The Nutritional Belgian Recommendations of 2016 were used, i.e., adequate intake and estimated average requirement (EAR). For micronutrients, the prevalence of insufficient intake was estimated as the proportion of subjects whose intake was below the EAR. Results: A total of 331 subjects (mean age of 74.8 ± 5.9 years, 58.9% women) had complete data and were included in this study. Among them, 51 were diagnosed with sarcopenia (15.4%). In the fully adjusted model, analyses revealed that sarcopenic subjects consumed significantly lower amounts of two macronutrients (proteins, lipids) and five micronutrients (potassium, magnesium, phosphorus, iron, and vitamin K) than non-sarcopenic subjects (all p values < 0.005). A significantly increased prevalence of insufficiency was found for sarcopenic subjects compared to non-sarcopenic subjects for potassium, magnesium, iron, calcium and vitamins E and C (all p values < 0.005). The prevalence of sarcopenic subjects who were also below the Nutritional Belgian Recommendations for protein and lipids was significantly higher than that of non-sarcopenic subjects. Discussion and conclusions: Sarcopenic subjects seem to consume significantly reduced amounts of many micronutrients and macronutrients compared to non-sarcopenic subjects. These results suggest that a poorly balanced diet may be associated with sarcopenia and poor musculoskeletal health, although prospective studies are needed to confirm these findings. © 2019, Springer Nature Switzerland AG. [less ▲]

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See detailCompte-rendu de M. Lærke, Ch. Leduc, D. Rabouin, "Leibniz. Lectures et commentaires"
Dony, Arthur ULiege

in Revue Philosophique de Louvain (in press)

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See detailOvercoming familiarity illusions in a single case with persistent déjà vu
Ernst, Alexandra ULiege; DELRUE, Gaël ULiege; Willems, Sylvie ULiege

in Memory (in press)

While occasional déjà vu is benign in the general population, rare neuropsychological cases with persistent déjà vu have been described in the literature. We report the case of MN, a 25-year-old woman ... [more ▼]

While occasional déjà vu is benign in the general population, rare neuropsychological cases with persistent déjà vu have been described in the literature. We report the case of MN, a 25-year-old woman, who suffered a cerebral haemorrhage in the right thalamo-callosal region and experienced recurrent déjà vu episodes. Through clinical interviews and memory tasks related to déjà vu, we assumed that source memory errors and an inappropriate feeling of familiarity (measured by the number of false recognitions) were critically involved in MN’s déjà vu. Based on this, we developed the first neuropsychological intervention dedicated to déjà vu. The rationale was to train MN to detect elements that could produce an inappropriate feeling of familiarity and to promote metacognitive awareness about déjà vu. This intervention was effective at reducing the frequency of déjà vu episodes in MN’s daily life, as well as the number of false recognitions in memory tasks. In addition to its clinical contribution, this single-case study contributes to the limited literature on patients whose déjà vu is not related to epileptic abnormalities and medial temporal brain damage, and provide supportive evidence of the role of an erroneous feeling of familiarity and of metacognitive processes in déjà vu. [less ▲]

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See detailExposure of workers to pesticide residues during re-entry activities: A Review
Toumi, Khaoula ULiege; Joly, Laure; Vleminckx, Christiane et al

in Human and Ecological Risk Assessment (in press)

Workers may be exposed to pesticide residues when they enter an area that has been previously treated in order to realize different tasks (e.g. for pruning, cutting, picking, harvesting, pest scouting) or ... [more ▼]

Workers may be exposed to pesticide residues when they enter an area that has been previously treated in order to realize different tasks (e.g. for pruning, cutting, picking, harvesting, pest scouting) or to handle a contaminated crop commodity (e.g. sorting, bundling, packing). A review of the scientific literature on workers exposed to pesticide residues during re-entry tasks provides a comprehensive view of possible exposure routes and a better understanding of the risk assessment context, threshold values and calculation methodology. Methods assessing the risk to workers health are also reported and discussed. The impact of re-entry activities on health and factors affecting workers exposure are examined. Finally, solutions and mitigation measures aiming to reduce their exposure to pesticide residues are recommended. [less ▲]

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See detailA comparative study of labeling algorithms within the branch-and-price framework for vehicle routing with time windows
Michelini, Stefano ULiege

in 4OR: A Quarterly Journal of Operations Research (in press)

Ph. D Thesis summary, see other reference on ORBI

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See detailBone metabolism markers are associated with neck circumference in adult Arab women.
Albassam, R.S.; Sabico, S.; Alnaami, A.M. et al

in Osteoporosis International (in press)

Summary: The study aimed to determine whether neck circumference is associated with bone metabolism markers among adult Arab women and found modest but significant associations with bone resorption ... [more ▼]

Summary: The study aimed to determine whether neck circumference is associated with bone metabolism markers among adult Arab women and found modest but significant associations with bone resorption markers, suggesting that neck circumference, a surrogate measure of upper subcutaneous fat, influences bone turnover expression among adult females. Introduction: Body fat distribution is associated with decreased bone resorption and neck circumference (NC), a surrogate measure for upper body fat, has never been tested as a marker that can reflect bone turnover. This is the first study aimed to analyze the associations between NC and several bone biomarkers among adult Saudi women. Methods: This cross-sectional study included a total of 265 middle-aged Saudi women [86 non-obese (mean age 52.7 ± 8.1; mean BMI 26.9 ± 2.3) and 179 obese (mean age 50.6 ± 7.5; mean BMI 35.7 ± 4.5)] recruited from primary care centers in Riyadh, Saudi Arabia. Anthropometrics included BMI, NC, waist and hip circumferences, total body fat percentage (%), and blood pressure. Biochemical parameters included glucose and lipid profile which were measured routinely. Serum levels of 25(OH) D, parathyroid hormone, RANKl, sclerostin, C-terminal telopeptide of collagen I (CTX-I), Dkk1, IL1β, osteoprotegerin, osteopontin, and osteocalcin were measured using commercially available assays. Results: In all groups, NC was inversely associated with PTH (R = − 0.22; p < 0.05) and positively associated with osteoprotegerin (R=0.20; p < 0.05) even after adjustments for age and BMI. Using all anthropometric indices as independent variables showed that only NC explained the variance perceived in CTX-I (p = 0.049). In the non-obese, waist-hip ratio (WHR) was significantly associated with sclerostin (R = 0.40; p < 0.05) and body fat was significantly associated with osteopontin (R=0.42; p<0.05). Conclusion: NC is modestly but significantly associated with bone biomarkers, particularly the bone resorption markers, among adult Arab women. The present findings highlight the importance of NC as measure of upper body subcutaneous fat in influencing bone biomarker expression in adult females. [less ▲]

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See detailHunting down the source: how amnesic patients avoid fluency-based memory errors
Geurten, Marie ULiege; Bastin, Christine ULiege; Salmon, Eric ULiege et al

in Neuropsychology (in press)

Objective: The primary aim of this study was to test whether differences in the ability of amnesic and healthy participants to detect alternative sources of fluency can account for differences observed in ... [more ▼]

Objective: The primary aim of this study was to test whether differences in the ability of amnesic and healthy participants to detect alternative sources of fluency can account for differences observed in the use of fluency as a cue for memory. Method: Patients with severe memory deficits and matched controls were presented with three forced-choice recognition tests. In each test, an external source of fluency was provided by manipulating the perceptual quality of the studied items during the test phase. The detectability of the perceptual manipulation varied in each test (i.e., a 10%, 20%, or 30% contrast reduction were given). Results: The results indicated that all participants were able to rely on fluency when making recognition decisions as long as the perceptual manipulation remained unnoticed. Interestingly, our data also revealed that the level of contrast reduction at which the alternative source is detected differs between healthy controls and amnesic patients. Specifically, patients with amnesia appeared to disqualify fluency as a cue for memory even when the contrast reduction was moderate while healthy participants only disqualified fluency when the contrast reduction was clearly visible. Conclusion: Overall, our results seem to suggest that the ability to use fluency is probably not impaired in amnesia but undergo metacognitive changes resulting in the implementation of explicit or implicit strategies aiming at tracking alternative sources in order to reduce memory errors. [less ▲]

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See detailÉvaluation psychiatrique et hospitalisation contrainte d'urgence. Analyse rétrospective de dossiers
Schmits, Emilie ULiege; Evrard, Maude; Valassopoulou, Eftichia et al

in Annales Médico-Psychologiques (in press)

Objectives: Psychiatric cares sometimes lead to coercive measures for the patient. Emergency procedures are initiated by the competent Public Prosecutor who can decide to hospitalize patient under ... [more ▼]

Objectives: Psychiatric cares sometimes lead to coercive measures for the patient. Emergency procedures are initiated by the competent Public Prosecutor who can decide to hospitalize patient under constraint on the basis of a medical certificate. This procedure raises questions at different levels. The present study included several objectives: (1) investigation of the profile of the patients; (2) practical application of this type of procedure; (3) evaluation of the criteria related to the decision-making process leading to forced hospitalization. Method: This study was conducted in a Medical-Psycho-Social emergency unit in Belgium. This is a retrospective search, conducted on the basis of file analyses. Were included all patients who experienced emergency psychiatric assessment at the request of the magistrate. The following information were collected: date and time of admission, date of birth, sex, sector, diagnosis, use of therapeutic isolation, outcome of the evaluation, type of support, and the sex of the evaluators. These data were analyzed through descriptive and inferential statistical analyses. Results: Two hundreds and thirty-eight 238 persons were admitted in the emergency unit at the request of a magistrate. The average age is 39.99 years (59.66% men) and 62.18% of patients are registered in their hospital sector, while 34.87% of admissions are made outside the sector. Psychiatric night care is activated in 34.03% of cases, while 28.15% of psychiatric assessment requests arrive in the morning and 37.39% in the afternoon. The service receives between 4 and 5 requests from the magistrate per week. While 15.96% of them are referred on weekends, 84.04% are sent to the service on weekdays. Regarding the main diagnosis, 42.43% show a psychotic disorder, 13.44% a (hypo) manic episode, 10.50% an abuse of substance, 9.66% of behavioral disorders, 7.56% a personality disorder, 5.88% an adjustment disorder, 5.05% a depressive disorder and 3.36% a mental retardation. Therapeutic isolation is used in 34.87% of situations. In 55.04% of the cases, the procedure was stopped, while 43.69% lead to hospitalization under constraint. If the procedure is stopped, another follow-up is proposed: 22.38% of in-house ambulatory follow-up, 16.41% of outpatient follow-up, 14.17% with a mobile unit, 9.70% of in-house hospitalization, 9.70% of judicial follow-up, 8.95% of care by a medical service, 5.22% of network referral, and 2.23% of social follow-up. Patients whose assessment leads to hospitalization under constraint are significantly older than those whose procedure is stopped. The sex of the patient does not influence the outcome of the assessment. The decision to hospitalize under constraint is not influenced by the time of admission or the sex of the evaluator. However, the results demonstrate a significant link between therapeutic isolation and the decision to hospitalize under constraint. Patients spending the night in the emergency room are more often hospitalized under constraint. In addition, the main diagnosis posed is significantly related to the outcome of the psychiatric evaluation. The majority of people diagnosed with psychotic disorders and (hypo) manic episodes are hospitalized under constraint, while people met for substance abuse, behavioral disorders and adjustment disorders are not. A very small proportion of patients with personality disorder, depressive disorder or mental retardation are forced into hospital. Conclusion: This study provides detailed descriptions of the patients involved in the emergency procedure and its practical application, as well as the identification of factors related to forced hospitalization. This work allows an inventory of the urgent procedure (psychiatric assessment and forced hospitalization) and improves the understanding of psychiatric procedures and practices. © 2018 Elsevier Masson SAS [less ▲]

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See detailMaqriziana XIV: Al-Maqrīzī’s Last Opus (Al-Ḫabar ʿan al-Bašar) and Its Significance for the History of Islam
Bauden, Frédéric ULiege

in Journal of the Royal Asiatic Society (in press)

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See detailPhotologie, linéarité et modernité politique. Du geste philosophique derridien
Petteni, Oriane ULiege

in Éthique, Politique, Religions (in press), 1/n°12

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See detailWheels for people with disabilities in the post-apartheid city
Schnitzler, Marie ULiege

in Africa (in press)

This article focuses on technologies of mobility for people with physical disabilities living in a South African poor urban setting. It moves away from a perspective that exposes limitations to underline ... [more ▼]

This article focuses on technologies of mobility for people with physical disabilities living in a South African poor urban setting. It moves away from a perspective that exposes limitations to underline specific opportunities for people with disabilities to design the city. In the township of Mitchell’s Plain (Cape Town), known for its violence, defining when and where to use the chair involves a negotiation of moral and medical norms with a pursuit of security. In this process, the wheelchair constitutes one element of a larger continuum of wheeled mobility. The availability of public and private alternative transport enhances already present inequalities among people with disabilities. Two systems of public transport are further discussed, namely Dial-a-Ride (a specialized transport) and MyCiTi bus (a mainstream service). Initiatives of the City of Cape Town, these transports are widely discussed and criticized by people with disabilities. Through discussion with or opposition to the local government, associations participate actively in their inclusion in the post-apartheid city. My conclusions, drawn upon nineteen months of ethnographic fieldwork, call upon the theoretical framework of the anthropology of material things and the sociology of space. [less ▲]

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See detailA threesome is healthier than a love triangle: connecting planetary health, climate change and migration
Schütte, Stefanie; Gemenne, François ULiege; Depoux, Anneliese et al

in The Lancet Planetary Health (in press)

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See detailUnderstanding the diverse scaling strategies of social enterprises as hybrid organizations: the case of renewable energy cooperatives
Bauwens, Thomas; Huybrechts, Benjamin ULiege; Dufays, Frédéric

in Organization and Environment (in press)

This paper seeks to shed light on the diversity of scaling strategies of social enterprises, which can be considered as emblematic hybrid organizations. By comparing three Flemish renewable energy ... [more ▼]

This paper seeks to shed light on the diversity of scaling strategies of social enterprises, which can be considered as emblematic hybrid organizations. By comparing three Flemish renewable energy cooperatives with contrasted scaling strategies, the paper shows how these strategies can be understood in relation to the organizational mission as imprinted at the founding. We extend the notion of hybridity beyond the combination of institutional logics to highlight the interest orientation (mutual versus general interest). Unlike what is suggested in extant literature, we find that mutual interest orientation may be associated with ‘scale up’, business growth strategies, while general interest orientation may lead to less growth-focused ‘scale out’ and ‘scale deep’ strategies. The findings illuminate aspects of the hybrid nature of social enterprises by explaining their diverse scaling strategies, and extend the notion of imprinting to the inter-organizational level by highlighting how social enterprises may collaborate to collectively achieve the pursuit of their multiple missions. [less ▲]

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See detailUnder which humidity conditions are moss spore released? A comparison between species with perfect and specialized peristomes
Zanatta, F.; Vanderpoorten, Alain ULiege; Hedenäs, L. et al

in Ecology and Evolution (in press)

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See detailEffects of gain-loss frames on advantageous inequality aversion
Lefebvre, Mathieu ULiege; bounmy, Kene; Lampach, Nicolas

in Journal of the Economic Science Association (in press)

This paper studies individuals’ preference for reducing advantageous inequality in the distribution of gains and losses. Combining the inequality aversion model of Fehr and Schmidt (Q J Econ 114(3 ... [more ▼]

This paper studies individuals’ preference for reducing advantageous inequality in the distribution of gains and losses. Combining the inequality aversion model of Fehr and Schmidt (Q J Econ 114(3):817–868, 1999) with loss aversion à la Kahneman and Tversky (Econom J Econom Soc:263–291, 1979), we predict the relative dislike for advantageous inequality is lower when outcomes are framed as losses than when outcomes are framed as gains. We test this prediction using data from two modified dictator game experiments. Consistent with the model, we find that the amount of payoff that subjects are willing to sacrifice to increase the net payoff of others and reduce advantageous inequality is smaller under a loss frame than under a gain frame. The results also show that women are more inequality averse than men in both gains and losses. [less ▲]

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See detailIron and Trace Element in Paediatric Parenteral Nutrition
Domellof, M; Szitanyi, P; Simchowitz, V et al

in Clinical Nutrition (in press)

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See detailOfficial Memories and Legal Constraints. A Classification of Memory Instruments in France and Belgium
Grandjean, Geoffrey ULiege

in Memory Studies (in press)

Public authorities do not have a monopoly over memory constraint in the sense that they are not alone in promoting collective memories. However, the article suggests a classification of the memory ... [more ▼]

Public authorities do not have a monopoly over memory constraint in the sense that they are not alone in promoting collective memories. However, the article suggests a classification of the memory instruments in France and Belgium according to the degree of legal constraint (sanctioning, prescriptive and latent). This classification offers a new understanding of the exercise of the legal constraints which are a way for the public authorities to offer specific accounts of certain past events. [less ▲]

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See detailThe persistence of carbon in the African forest understory
Hubau, Wannes; De Mil, Tom; Van den Bulcke, Jan et al

in Nature Plants (in press)

Quantifying carbon dynamics in forests is critical for understanding their role in long-term climate regulation1–4. Yet little is known about tree longevity in tropical forests3,5–8, a factor that is ... [more ▼]

Quantifying carbon dynamics in forests is critical for understanding their role in long-term climate regulation1–4. Yet little is known about tree longevity in tropical forests3,5–8, a factor that is vital for estimating carbon persistence3,4. Here we calculate mean carbon age (the period that carbon is fixed in trees7) in different strata of African tropical forests using (1) growthring records with a unique timestamp accurately demarcating 66 years of growth in one site and (2) measurements of diameter increments from the African Tropical Rainforest Observation Network (23 sites). We find that in spite of their much smaller size, in understory trees mean carbon age (74 years) is greater than in sub-canopy (54 years) and canopy (57 years) trees and similar to carbon age in emergent trees (66 years). The remarkable carbon longevity in the understory results from slow and aperiodic growth as an adaptation to limited resource availability9–11. Our analysis also reveals that while the understory represents a small share (11%) of the carbon stock12,13, it contributes disproportionally to the forest carbon sink (20%). We conclude that accounting for the diversity of carbon age and carbon sequestration among different forest strata is critical for effective conservation management14–16 and for accurate modelling of carbon cycling4. [less ▲]

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See detailEnfermement carcéral, imaginaire et pathologie de l’adaptation
Englebert, Jérôme ULiege

in Empan (in press)

Cet article interroge le sort réservé à l’imaginaire dans l’univers carcéral. Une étude minutieuse de ce phénomène fournit des informations sur la psychologie intime de l’homme incarcéré (ses rapports au ... [more ▼]

Cet article interroge le sort réservé à l’imaginaire dans l’univers carcéral. Une étude minutieuse de ce phénomène fournit des informations sur la psychologie intime de l’homme incarcéré (ses rapports au rêve, au corps, à l’altérité, à l’espace et au temps). Ponctuée par une situation clinique, l’étude identifie ce que Sami-Ali appelle le banal (monde hyper-réel duquel les possibilités d’émancipation par l’imaginaire sont réduites, voire inexistantes) comme étant la dynamique de fond du vécu carcéral. L’individu y devient un « être unique en général », rouage anonyme d’une organisation qui le dépasse. [less ▲]

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See detailLes haruspices publics au service de Rome : des aristocrates convoqués d’Étrurie ? Quels aristocrates ?
Berthelet, Yann ULiege

in Dialogues d'Histoire Ancienne (in press)

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See detailLes French Studies américaines au tournant du XXIe siècle – enjeux et discours d’une crise identitaire
Daubercies, Laurence ULiege

in MethIS: Méthodes et Interdisciplinarité en Sciences Humaines (in press), 5

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See detailRéformes territoriales : où en est la Belgique ?
Husson, Jean-François ULiege

in Revue Européenne de l’Action Publique (in press)

Présentation de l'état des réformes territoriales en Belgique.

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