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See detailLes leucémies chroniques. Aspects cliniques et thérapeutiques.
Fillet, Georges ULiege

in Actualité Médicale Belge (1982), 9

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See detailLeucocyte subsets in the respiratory tract of dogs without respiratory disease : preliminary results.
Peeters, Dominique ULiege; Day, M. J.; Laurent, A. et al

in Proceedings of the 12th Annual Congress of the ECVIM-CA (2002)

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See detailLeucocytes and lipid particles filtration in suction blood during cardiopulmonary bypass: impact on kidney function evaluated with a monocentric prospective randomized study.
LAGNY, Marc-Gilbert ULiege; KOCH, Jean-Noël ULiege; BLAFFART, Francine ULiege et al

Conference (2015, October 03)

OBJECTIVE: Cardiac surgery may be complicated by acute kidney injury (AKI). Cardiotomy suction during cardiopulmonary bypass (CPB) is deleterious. A few studies have demonstrated that shed mediastinal ... [more ▼]

OBJECTIVE: Cardiac surgery may be complicated by acute kidney injury (AKI). Cardiotomy suction during cardiopulmonary bypass (CPB) is deleterious. A few studies have demonstrated that shed mediastinal blood (SMB) suction during cardiopulmonary bypass (CPB) can increase inflammatory response and lipids emboli. These 2 factors contribute to the development of postoperative AKI. The RemoweLL (RemoweLeucoLipids, Eurosets™, Italy) filter is a recent designed cardiotomy with a multilayer filter for activated leucocytes filtration and a syphon for lipid particles sequestration. The SMB can be collected and filtered in this supplementary cardiotomy added to CPB circuit. The aim of this monocentric prospective study was to compare the specific RemoweLL cardiotomy filtration for suction blood during CPB and a conventional 40 µm filter (Admiral, Eurosets™, Italy). The primary goal was to evaluate the AKI within 48 hours after surgery using the Acute Kidney Injury Network classification (AKIN classification) but also measuring early specific biomarkers of AKI: serum Cystatine C and urinary neutrophil gelatinase-associated lipocalin (NGAL). METHODS: Sixty patients scheduled for elective cardiac surgery (aortic or mitral valvular combined or not with coronary bypass grafting) with a glomerular filtration rate (GFR) > 45mL/min. were randomly into 2 groups for SMB filtration: - Groupe 1 (n=30) with RemoweLL cardiotomy (Leucocytes and lipids filter); - Groupe 2 (n=30) with Admiral cardiotomy (conventional 40 µm filter). All components: venous reservoir, oxygenator and surface treatment were similar in both groups. [less ▲]

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See detailLeucoencephalite aigue hemorragique de Hurst: imagerie IRM.
Tshibanda, L.; NCHIMI LONGANG, Alain ULiege; Otte, Manuel et al

in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2007), 90(4), 290-3

A case of autopsy-proven acute hemorrhagic leukoencephalitis is reported. Early magnetic resonance imaging showed extensive bilateral asymmetrical demyelinating lesions and foci of microhemorrhage sparing ... [more ▼]

A case of autopsy-proven acute hemorrhagic leukoencephalitis is reported. Early magnetic resonance imaging showed extensive bilateral asymmetrical demyelinating lesions and foci of microhemorrhage sparing the cortex ribbon. Fulminant disease culminated in coma and death within twenty-four hours. A comprehensive correlation between pathological findings of acute haemorrhagic leukoencephalitis and both classical and advanced neuroimaging findings is provided. [less ▲]

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See detailLeuconoritic dikes: new evidence for injected crystal mushes from the Löyning lens (Egersund-Ogna Massif, Rogaland, Norway)
Duchesne, Jean-Clair ULiege; Ernst, Gerald; Hertogen, Jan

Conference (1991, September 14)

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See detailLeukemia inhibitory factor induces an antiapoptotic response in oligodendrocytes through Akt-phosphorylation and up-regulation of 14-3-3.
Slaets, Helena; Dumont, Debora; Vanderlocht, Joris et al

in Proteomics (2008), 8(6), 1237-47

Leukemia inhibitory factor (LIF) promotes the survival of oligodendrocytes (OLG) both in vitro and in an animal model of multiple sclerosis. Here, we show that LIF protects mature rat OLG cultures ... [more ▼]

Leukemia inhibitory factor (LIF) promotes the survival of oligodendrocytes (OLG) both in vitro and in an animal model of multiple sclerosis. Here, we show that LIF protects mature rat OLG cultures selectively against the combined insult of the proinflammatory cytokines interferon-gamma and tumor necrosis factor-alpha, but it does not protect against oxidative stress nor against staurosporine induced apoptosis. We further demonstrate that LIF activates the janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) and the phosphatidylinositol 3 kinase/Akt pathway in mature OLG. We show that LIF protection is independent of suppressors of cytokine signaling and Bcl-2 mRNA expression levels. To gain further insight into the protective mechanism, a quantitative proteomic approach (DIGE) was applied to identify differentially expressed proteins in LIF-treated OLG. Our results indicate that LIF induces a shift in the cellular machinery toward a prosurvival execution program, illustrated by an enhanced expression of isoforms of the antiapoptotic molecule 14-3-3. These data provide further insight into the mechanisms of LIF-mediated protection of mature OLGs. [less ▲]

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See detailLeukemia Viruses
Burny, A.; Bex, F.; Dequiedt, Franck ULiege et al

in Encyclopedia of Immunology (1998)

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See detailLeukemia Viruses
Burny, A.; Willems, Luc ULiege

in Encyclopedia of Immunology (1991)

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See detailLeukemic cell xenograft in zebrafish embryo for investigating drug efficacy.
Pruvot, Benoist ULiege; Jacquel, Arnaud; Droin, Nathalie et al

in Haematologica (2011), 96(4), 612-6

Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored ... [more ▼]

Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored human leukemic cell xenograft in zebrafish embryos. Human leukemic cell lines and blast cells sorted from patients with acute myelogenous leukemia were injected 48 hours post-fertilization and remained in the circulation of zebrafish embryos for several days without affecting their development. Imatinib and oxaphorines did not demonstrate any toxicity on normal zebrafish embryos and decreased the leukemic burden in animals xenografted with sensitive leukemic cell lines. Two other molecules, all-trans retinoic acid and the translation inhibitor 4EGI-1, demonstrated teratogenic effects at concentrations shown to be efficient in vitro, which precluded investigation of their antileukemic activity in such models. Altogether, xenografted leukemic cells in zebrafish embryos are a pharmacologically relevant model for screening non-teratogenic drugs. [less ▲]

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See detailLeukemic target susceptibility to natural killer cytotoxicity: relationship with BCR-ABL expression.
Baron, Frédéric ULiege; Turhan, Ali G; Giron-Michel, Julien et al

in Blood (2002), 99(6), 2107-13

Chronic myeloid leukemia is a clonal myeloproliferative expansion of transformed primitive hematopoietic progenitor cells characterized by high-level expression of BCR-ABL chimeric gene, which induces ... [more ▼]

Chronic myeloid leukemia is a clonal myeloproliferative expansion of transformed primitive hematopoietic progenitor cells characterized by high-level expression of BCR-ABL chimeric gene, which induces growth factor independence. However, the influence of BCR-ABL expression on cell-mediated cytotoxicity is poorly understood. In the present study, we asked whether BCR-ABL expression interferes with leukemic target sensitivity to natural killer (NK) cell cytolysis. Our approach was based on the use of 2 BCR-ABL transfectants of the pluripotent hematopoietic cell line UT-7 expressing low (UT-7/E8, UT-7/G6) and high (UT-7/9) levels of BCR-ABL. As effector cells, we used CD56(bright), CD16-, CD2- NK cells differentiated in vitro from CD34 cord blood progenitors. We demonstrated that BCR-ABL transfectants UT-7/9 were lysed by NK cells with a higher efficiency than parental and low UT-7/E8.1 and UT-7/G6 transfectants. This enhanced susceptibility to lysis correlated with an increase in expression of intercellular adhesion molecule 1 (ICAM-1) by target cells. Treatment of UT-7/9 cells by STI571 (a specific inhibitor of the abl kinase) resulted in a decrease in NK susceptibility to lysis and ICAM-1 down-regulation in target cells. Furthermore, the constitutive activation of nuclear factor-kappaB (NF-kappaB) detected in BCR-ABL transfectant UT-7/9, was significantly attenuated when cells were treated by STI571. Interestingly, inhibition of NF-kappaB activation by BAY11-67082 (a specific NF-kappaB inhibitor) resulted in down-regulation of ICAM-1 expression and a subsequent decrease in NK-induced killing of UT-7/9 transfectants. Our results show that oncogenic transformation by BCR-ABL may increase susceptibility of leukemic progenitors to NK cell cytotoxicity by a mechanism involving overexpression of ICAM-1 as a consequence of NF-kappaB activation. [less ▲]

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See detailLeukemie bij runderen: model voor leukemie veroorzaakt door een retrovirus
Willems, Luc ULiege; Burny, A.; Kettmann, Richard ULiege

in Kanker (1991)

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See detailLeukemogenesis by bovine leukemia virus (BLV)
Burny, A.; Cleuter, Y.; Dandoy, C. et al

in Viruses and human cancer, Liss Press, New York (1987)

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See detailLeukemogenesis by bovine leukemia virus (BLV) and human T-cell lymphotropic viruses : facts and hypotheses
Burny, A.; Cleuter, Y.; Kettmann, Richard ULiege et al

in Cancer letters (suppl.) (1986)

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See detailLeukemogenesis by transactivating retroviruses : bovine leukemia virus as a model system
Burny, A.; Cleuter, Y.; Dandoy, C. et al

in Concepts and theories in carcinogenesis (1987)

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See detailLeukemogenesis by transactivating retroviruses: bovine leukemia virus as a model system
Burny, A.; Kettmann, Richard ULiege; Mammerickx, M. et al

in Springer-Verlag Press (Berlin, Heidelberg) (1988)

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See detailLeukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis.
Lacroix, Romaric; Plawinski, Laurent; Robert, Stephane et al

in Haematologica (2012), 97(12), 1864-72

BACKGROUND: We recently assigned a new fibrinolytic function to cell-derived microparticles in vitro. In this study we explored the relevance of this novel property of microparticles to the in vivo ... [more ▼]

BACKGROUND: We recently assigned a new fibrinolytic function to cell-derived microparticles in vitro. In this study we explored the relevance of this novel property of microparticles to the in vivo situation. DESIGN AND METHODS: Circulating microparticles were isolated from the plasma of patients with thrombotic thrombocytopenic purpura or cardiovascular disease and from healthy subjects. Microparticles were also obtained from purified human blood cell subpopulations. The plasminogen activators on microparticles were identified by flow cytometry and enzyme-linked immunosorbent assays; their capacity to generate plasmin was quantified with a chromogenic assay and their fibrinolytic activity was determined by zymography. RESULTS: Circulating microparticles isolated from patients generate a range of plasmin activity at their surface. This property was related to a variable content of urokinase-type plasminogen activator and/or tissue plasminogen activator. Using distinct microparticle subpopulations, we demonstrated that plasmin is generated on endothelial and leukocyte microparticles, but not on microparticles of platelet or erythrocyte origin. Leukocyte-derived microparticles bear urokinase-type plasminogen activator and its receptor whereas endothelial microparticles carry tissue plasminogen activator and tissue plasminogen activator/inhibitor complexes. CONCLUSIONS: Endothelial and leukocyte microparticles, bearing respectively tissue plasminogen activator or urokinase-type plasminogen activator, support a part of the fibrinolytic activity in the circulation which is modulated in pathological settings. Awareness of this blood-borne fibrinolytic activity conveyed by microparticles provides a more comprehensive view of the role of microparticles in the hemostatic equilibrium. [less ▲]

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See detailLeukotriene B4 Contributes to Exhaled Breath Condensate and Sputum Neutrophil Chemotaxis in COPD.
Corhay, Jean-Louis ULiege; Henket, Monique ULiege; Nguyen Dang, Delphine ULiege et al

in CHEST (2009), 136(4), 1047-1054

Background Neutrophils have been implicated in the pathogenesis of COPD. Several chemoattractants for neutrophils have been measured in exhaled breath condensate (EBC) and induced-sputum (IS) from ... [more ▼]

Background Neutrophils have been implicated in the pathogenesis of COPD. Several chemoattractants for neutrophils have been measured in exhaled breath condensate (EBC) and induced-sputum (IS) from patients with COPD. Objectives The aims of this study were to compare EBC and IS supernatant neutrophil chemotactic activity from ex-smoking COPD and healthy ex-smokers, and to assess the contribution of LTB(4) to this activity. Methods 34 COPD were compared to 24 controls. EBC and IS chemotactic activity for neutrophils were assessed by using Boyden microchambers. Chemotactic index (CI) was used to evaluate cell migration. LTB(4) was measured by a specific enzyme immunoassay. Contribution of LTB4 to EBC and sputum neutrophil chemotaxis was assessed by an LTB(4) receptor antagonist (U-75302: Cayman Chemical Company, Ann Arbor, MI, USA). Results EBC and IS from both COPD and healthy subjects displayed significant neutrophil chemotactic activity but this activity was raised in COPD compared to healthy subjects. Chemotactic activity contained in sputum, however, failed to correlate with that in EBC. In COPD there was a significant correlation between EBC neutrophil chemotactic activity and sputum neutrophil counts. LTB(4) levels were raised in EBC, but not in sputum, from COPD as compared to healthy subjects. LTB(4) receptor antagonist (2.5 10(-4) M) reduced by 44.6% and by 44.4% chemotactic activity contained in EBC and sputum respectively. Conclusions EBC and IS from COPD patients have a raised neutrophil chemotactic activity to which LTB4 contributes. [less ▲]

Detailed reference viewed: 62 (6 ULiège)
See detailLeur première pièce. L'émergence des auteurs dramatiques dans le théâtre belge francophone
Delhalle, Nancy ULiege

Scientific conference (2011, April 27)

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See detailLeurres de la qualité dans l'enseignement supérieur ? Variations internationales sur un thème ambigu
Fallon, Catherine ULiege; Leclercq, Bruno ULiege

Book published by Academia-L'Harmattan (2014)

Comme d’autres services publics, l’enseignement supérieur s’est, en quelques années seulement, doté, partout dans le monde, de dispositifs d’évaluation « Qualité ». Ces nouvelles approches mobilisent le ... [more ▼]

Comme d’autres services publics, l’enseignement supérieur s’est, en quelques années seulement, doté, partout dans le monde, de dispositifs d’évaluation « Qualité ». Ces nouvelles approches mobilisent le plus souvent des principes inspirés du New Public Management qui s'enracinent dans une critique néo-libérale de l’Etat providence. D’un endroit à l’autre, ce sont toutefois des méthodes, des critères et surtout des usages très différents de l’évaluation des formations qui se rangent sous cette appellation. Les textes rassemblés dans ce volume font état de cette diversité des pratiques internationales ainsi que de l’irréductible multiplicité des projets que cherche à servir simultanément la démarche « Qualité » dans l’enseignement supérieur. En soulignant les ambiguïtés d’un dispositif tout à la fois discursif et technique, ils cherchent à en déjouer les éventuels « leurres ». [less ▲]

Detailed reference viewed: 239 (23 ULiège)