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See detailIntra- and extracellular antioxidant capacities of the new water-soluble form of curcumin (NDS27) on stimulated neutrophils and HL-60 cells
Derochette, Sandrine ULiege; Franck, Thierry ULiege; Mouithys-Mickalad, Ange ULiege et al

in Chemico-Biological Interactions (2013), 201(1-3), 49-57

Phagocytic cells, especially neutrophils (PMNs) are specialized in the production of reactive oxygen species (ROS) to kill pathogenic agents, but an excessive ROS production is associated with tissue ... [more ▼]

Phagocytic cells, especially neutrophils (PMNs) are specialized in the production of reactive oxygen species (ROS) to kill pathogenic agents, but an excessive ROS production is associated with tissue damages and inflammatory diseases. Phagocytes are thus prime therapeutic targets to control inflammatory events associated to ROS production. Nowadays, there is a growing interest for the use of polyphenols to modulate the inflammatory response. The aim of this work was to study the antioxidant effect of NDS27, a highly water-soluble form of the polyphenolic molecule curcumin, on in vitro stimulated equine PMNs and human promyelocytic leukemia cells (HL-60). NDS27 was either pre-incubated with cells and eliminated before their activation (intracellular effect) or let in the medium (extracellular effect). Our results indicate that NDS27 significantly and dose-dependently (10 6 M–10 4 M) inhibited the ROS production in both cell types without affecting their viability. NDS27 was able to cross and interact with cell membrane, especially for HL-60 cells, while we observed a better intracellular antioxidant effect with PMNs. The activity of myeloperoxidase (MPO) released by PMNs and HL-60 cells, was decreased by NDS27, but more efficiently for PMNs. These results suggested that the greater efficiency of NDS27 in PMNs is due to an inhibitory effect on cells which are more mature for ROS production, probably by targeting the enzymes implied in respiratory burst like MPO. The modulatory effect of NDS27 on the oxidant activity of cells involved in immune and inflammatory responses opens perspectives for a therapeutic control of pathologies with excessive inflammatory reactions. [less ▲]

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See detailIntra- and extracellular free amino acids in young beef bulls of different breeds and conformations
Van Eenaeme, Christian ULiege; Hornick, Jean-Luc ULiege; Baldwin, Paule et al

in Proceedings of the 3th International Congress on Amino Acids (1993)

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See detailIntra-arterial thrombolysis of thrombosed popliteal artery aneurysm. A series of six cases
Van Damme, Hendrik ULiege; Trotteur, Geneviève ULiege; Kerzmann, Arnaud ULiege et al

in Acta Chirurgica Belgica (2006), 106(6), 679-683

Aim of the study : To evaluate the role of perioperative, catheter-guided fibrinolysis in the management of thrombosed popliteal artery aneurysms. Material : From 1990 to 2005, six patients suffering ... [more ▼]

Aim of the study : To evaluate the role of perioperative, catheter-guided fibrinolysis in the management of thrombosed popliteal artery aneurysms. Material : From 1990 to 2005, six patients suffering subacute limb ischemia, secondary to thrombosis of a popliteal artery aneurysm, benefited selective intra-arterial fibrinolysis, followed by subsequent aneurysm exclusion and bypass grafting. This represents ten percent of all popliteal aneurysms operated on in that time period and 28% of all thrombosed popliteal artery aneurysms. Results : The lytic procedure was successful in all cases, restituting patency in two (n = 3), one (n = 2) or all (n = 1) crural arteries. The venous bypass graft remained patent in all but one patient. In one patient, the graft occluded at 10 months without limb loss. This outcome compares more favorable than the result obtained with emergent surgery alone for thrombosed popliteal artery aneurysms with profound limb ischemia (eight patients, of whom one required amputation at day 5 and one lost his limb at nine months following graft thrombosis). Conclusion : Preoperative intra-arterial lytic therapy, in the setting of subacute limb ischemia caused by thrombosis of a popliteal artery aneurysm, can be considered as safe and effective. [less ▲]

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See detailThe intra-articular injection of a new chitosan biomaterial prevents the progression of osteoarthritis in ACLT rabbit model
Oprenyeszk, Frédéric ULiege; Chausson, Mickael; Maquet, Véronique et al

in Osteoarthritis and Cartilage (2013, April), 21(Supplement April 2013), 69

Purpose To evaluate the effects of a single intra-articular injection of a new biomaterial consisting in a mix of alginate-chitosan (AC) beads and a viscous thermogelling chitosan-based (H) hydrogel on ... [more ▼]

Purpose To evaluate the effects of a single intra-articular injection of a new biomaterial consisting in a mix of alginate-chitosan (AC) beads and a viscous thermogelling chitosan-based (H) hydrogel on cartilage lesion in osteoarthritis (OA) rabbit model. These effects were compared to those obtained with the intra-articular injection of either chitosan-based (H) hydrogel without the AC bead or saline solution. Methods OA was surgically induced by the transection of the anterior cruciate ligament (ACLT) in HYLA albino rabbits. One week after surgery, animals were randomly divided into 3 groups: group I (n=7): mix of AC beads and H hydrogel; group II (n=7): H hydrogel alone; group III (n=7): saline solution (control). The treatments (900 µl) were injected intra-articularly. X-rays from the right knee were performed before surgery, at the time of injection and at sacrifice. The standard radiographs were acquired in extension and scored by the Kellgren and Lawrence (K&L) scale. After 6 weeks, animals were euthanized and the right joint was dissected. The macroscopic evaluation of cartilage from femoral condyles and tibial plateaus stained with India ink was done. Histological sections stained with Safranine-O/fast green from bearing areas of each compartment were evaluated according to the OARSI histological score. Briefly, the evaluation considered: staining of the cartilage matrix (0-6), cartilage structure (0-11), chondrocyte density (0-4) and cluster formation (0-3), where 0 represented a normal situation and 24 points the maximum severity score. Blood samples were collected the day of injection and prior the sacrifice. Prostaglandin E2 (PGE2) and C-reactive protein (CRP) were measured in serum using immunoassays. Results The X-rays analysis showed a significant decrease (p <0.05) of the K&L score in group I (AC beads and H hydrogel; 1.5 ± 0.2) compared with group II (H hydrogel; 2.2 ± 0.5) and group III (saline solution; 3.0 ± 0.4). The size and the severity of the macroscopic OA cartilage lesion tended to decrease in group I compared to the other groups. The histological global score that refers to all compartments of the knee joint was significantly decreased in group I (11.0 ± 0.7) compared to group II (14.4 ± 0.6, p <0.01) and group III (14.8 ± 0.6, p <0.001). No significant variation of PGE2 and CRP serum levels were observed in each after 6 weeks follow-up whatever the treatment injected. Conclusions This study showed that a biphasic hydrogel composed by AC beads and H hydrogel prevented OA in rabbit with ACL transection. This effect was not observed with the hydrogel alone, suggesting that AC beads play a role in joint protection. The preventive effect was observed in all joint compartments indicating a global protective effect of this new viscosupplementation. [less ▲]

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See detailThe intra-articular injection of alginate-chitosan beads in an hydrogel prevents the development of osteoarthritis in ACLT model
Oprenyeszk, Frédéric ULiege; Chausson, M; Maquet, V et al

Conference (2013, September 16)

Purpose To evaluate the effects of a new biomaterial composed of alginate-chitosan (AC) beads dispersed in a viscous thermogelling chitosan-based (H) hydrogel on the development of osteoarthritis (OA) in ... [more ▼]

Purpose To evaluate the effects of a new biomaterial composed of alginate-chitosan (AC) beads dispersed in a viscous thermogelling chitosan-based (H) hydrogel on the development of osteoarthritis (OA) in rabbit. Materials & Methods OA was surgically induced by the transection of the anterior cruciate ligament (ACLT) in rabbits. One week after surgery, animals received a single intra-articular injection (900 µl) of AC beads in H hydrogel (group I), H hydrogel alone (group II) or saline (group III). OA development was followed by X-rays. Blood samples were collected throughout the study to measure biological markers (PGE2 and CRP). Macroscopic observation and histological evaluation of articular cartilage and synovial membrane were performed 6 weeks after surgery. Results The X-rays analysis showed a significant decrease (p <0.05) of the Kellgren and Lawrence score in group I (1.5 ± 0.2) compared with group II (2.2 ± 0.5) and group III (3.0 ± 0.4). The size and the severity of the macroscopic OA cartilage lesion tended to decrease in group I compared to the other groups. The histological global score that refers to all compartments of the knee joint was significantly decreased in group I (11.0 ± 0.7) compared to group II (14.4 ± 0.6, p <0.01) and group III (14.8 ± 0.6, p <0.001). The injection of AC beads in H hydrogel also tended to reduce the synovial membrane inflammation. No significant variation of PGE2 and CRP serum levels were observed in each after 6 weeks follow-up whatever the treatment injected. Conclusion This study showed that AC beads dispersed in H hydrogel prevented OA in ACL transection rabbit model. This effect was not observed with the hydrogel alone, suggesting that AC beads play a role in joint protection. The preventive effect was observed in all joint compartments indicating a global protective effect of this new implantable biomaterial. [less ▲]

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See detailAn intra-articular supplementation method for treating joint diseases and injuries
Henrotin, Yves ULiege; Sanchez, Christelle ULiege; Oprenyeszk, Frédéric ULiege et al

Patent (2011)

A method of producing a hydrogel for intra-articular supplement comprising the steps of: - providing a solution of alginate, - providing a solution with chitosan having a Mw between lower than 60 kD ... [more ▼]

A method of producing a hydrogel for intra-articular supplement comprising the steps of: - providing a solution of alginate, - providing a solution with chitosan having a Mw between lower than 60 kD, - mixing the solution of alginate and the solution of chitosan, wherein the mixed solution comprises between 0.5 and 0.7 % (w/v) of chitosan and between 1 and 1.4 % alginate (w/v), - introducing droplets of the mixed solution into a solution with Ca2+ or Sr2+ cations and - isolating polymerised beads from the solution with cations [less ▲]

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See detailIntra-articular use of a medical device composed of hyaluronic acid and chondroitin sulfate (Structovial CS): effects on clinical, ultrasonographic and biological parameters
Henrotin, Yves ULiege; Hauzeur, Jean-Philippe; Bruel, Pierre et al

in BMC Research Notes (2012), 5(1), 407

BACKGROUND:This pilot open noncontrolled study was designed to assess the efficacy of intra articular injections of a solution combining hyaluronic acid (HA) and chondroitin sulphate (CS) in the treatment ... [more ▼]

BACKGROUND:This pilot open noncontrolled study was designed to assess the efficacy of intra articular injections of a solution combining hyaluronic acid (HA) and chondroitin sulphate (CS) in the treatment of outpatients affected by knee osteoarthrosis. Findings - Thirty patients with knee OA have been included. The primary objective was to assess clinical efficacy as measured by pain and Lequesne's index. Secondary objectives were to assess potential effect of the treatment on ultrasound parameters, safety and biomarkers of cartilage metabolism and joint inflammation. After a selection visit (V1), the study treatment was administered 3 times on a weekly basis (V2, V3, V4). Follow-up was planned 6 (V5) and 12 weeks (V6) after the first intra-articular injection. Efficacy results showed a reduction in mean pain at V3 and V6 and in functional impairment, the most marked changes being measured at the two follow-up visits (V5 and V6). Although statistical significance was not achieved due to small sample size, a clear tendency towards improvement was detectable for ultrasound assessments as well as biomarkers. Except for a mild injection site hematoma for which the drug causal relationship could not be excluded, no adverse effect of clinical relevance was recorded during the study.CONCLUSION:Although this pilot study was performed according to an open design only, the ultrasound as well as biomarkers changes strongly suggest a non-placebo effect. These preliminary results call now for a randomized controlled study to confirm the clinical relevance of the observed results. Trial registration #ISRCTN91883031 [less ▲]

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See detailIntra-cultivar potential of Desmanthus spp. as a greenhouse gas mitigation strategy for tropical livestock pastoral systems
Vandermeulen, Sophie ULiege; Ramírez-Restrepo, Carlos Alberto; Singh, Sultan et al

Poster (2015, November)

Improved agricultural efficiency and reduction in the impacts of tropical livestock farming on habitat degradation require global approaches that enhance ruminant farming functionality in terms of feed ... [more ▼]

Improved agricultural efficiency and reduction in the impacts of tropical livestock farming on habitat degradation require global approaches that enhance ruminant farming functionality in terms of feed use efficiency, emissions and food security. This study evaluated the in vitro mitigation potential of the prostrate to erect, herbaceous Desmanthus spp. pasture legume adapted to semiarid clay soil land types in northern Australia. D. bicornutus, D. leptophyllus and D. virgatus were seasonally harvested from commercial plots by Agrimix Pty. Ltd. Samples of the legumes and the control Rhodes grass (Chloris gayana) using ruminal fluid from grazing Brahman (Bos indicus) steers were incubated in vitro (Ankom RF1 Technology) for 24, 48 and 72 h. Overall, the in vitro organic matter degradability (OMD) and methane production between Desmanthus species differed (P < 0.001). Compared to the control (0.656 ± 0.027 proportion of total OM) at 48 h of incubation, D. leptophyllus showed lower OMD (0.479 ± 0.016), while D. bicornutus (0.688 ± 0.016) and D. virgatus (0.619 ± 0.015) were different from each other, but similar to the control. Methane production (ml/g OM) was 15.7 ± 1.54, 3.7 ± 0.89, 12.0 ± 0.95 and 11.7 ± 0.95, respectively. It is suggested that the impact of these attributes may benefit household farmers in developing economies to expand productivity, improve livelihoods and meet the growing food consumption. Further analyses of the intra-cultivar characteristics of Desmanthus spp. will complement the design of sustainable and efficient interventions across tropical pastoral feeding systems, with a particular emphasis on large-scale grazing operations. [less ▲]

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See detailIntra-European Mobility: Patterns of Immigration Flows and Policies
Barbulescu, Roxana; Lafleur, Jean-Michel ULiege; Stanek, Mikolaj

in Europa, Publications (Ed.) Western Europe 2016 (2015)

For decades, immigration has been at the core of the political and social debate in Europe. In the post-crisis environment, recent events have inflamed the migration agenda further, as freedom of movement ... [more ▼]

For decades, immigration has been at the core of the political and social debate in Europe. In the post-crisis environment, recent events have inflamed the migration agenda further, as freedom of movement is an essential decision-making point in the planned referendum on European Union (EU) membership in the United Kingdom, and the humanitarian crisis in the Mediterranean is testing the limits of the EU and of its member states to manage migration in a humane and fair way. Large- scale immigration has long challenged the Westphalian tradition of nation-state sovereignty in Europe (Joppke, 1998). However, these tensions have only increased over the last decade, following conflicts in Europe’s neighbourhood, the fall of the ‘Iron Curtain’ and the eastern enlargement of the EU, or the 2008 global economic and financial crisis. If until recently the most controversial aspect of immigration has been migrants and asylum-seekers from outside the EU and an invisibility of European migration and European migrants, in the last few years we observe that the very principle of migration from the other member states is challenged in a systematic manner for the first time since its proclamation in the Treaty of Rome (establishing the European Economic Community in 1958). The rebellion against the status quo on freedom of movement of people in the EU is led by Western European states. They are the almost exclusive receivers of EU migration, either from the other Western European states, or from the new member states in Central and Western Europe. This essay traces the transformation of EU migration over the last decade, following the most recent enlargements and the south–north migration which has re-emerged since the financial crisis, and examines the causes of an unprecedented contestation of free movement rights. [less ▲]

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See detailThe intra-nasal administration of insulin induces significant hypoglycaemia and classical counterregulatory hormonal responses in normal man.
Paquot, Nicolas ULiege; Scheen, André ULiege; Franchimont, P. et al

in Diabète & Métabolisme (1988), 14(1), 31-6

The present study aimed at investigating the metabolic and hormonal consequences of intra-nasal administration of insulin in normal man. Lyophylisated regular porcine insulin (Insuline Ordinaire Organon ... [more ▼]

The present study aimed at investigating the metabolic and hormonal consequences of intra-nasal administration of insulin in normal man. Lyophylisated regular porcine insulin (Insuline Ordinaire Organon) diluted with a non ionic detergent (Laureth-9 0,25%) was administered intra-nasally in 8 overnight fasted healthy volunteers using a calibrated aerosol delivery device (90 microliters = 9 U of insulin/spray) up to a total insulin dose close to 1 U/kg body weight. After intra-nasal insulin administration, plasma insulin levels rose from 5 +/- 1 to 38 +/- 10 mU/l (2p less than 0.01) at min 15, blood glucose concentrations decreased from 4.4 +/- 0.2 to 3.2 +/- 0.3 mmol/l (2p less than 0.01) at min 45, plasma C-peptide levels diminished from 327 +/- 31 to 174 +/- 28 mumol/l (2p less than 0.01) at min 60 and plasma free fatty acids concentrations fell from 336 +/- 109 to 130 +/- 31 mumol/l (2p less than 0.05) at min 30. The fall in blood glucose resulted in a prompt increase in plasma glucagon levels (from 78 +/- 28 to 150 +/- 24 ng/l at min 45; 2p less than 0.05) and in later rises in plasma growth hormone and cortisol concentrations. There was a close relationship between the individual maximal decreases in blood glucose levels and the individual maximal increases in plasma insulin (r = 0.81), glucagon (r = 0.88), cortisol (r = 0.87) and growth hormone (r = 0.76) concentrations.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailIntra-operative autologous transfusion in cancer patients.
Joris, Jean ULiege

in Acta Anaesthesiologica Belgica (2004), 55(1), 49-51

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See detailIntra-patient variability of SUV in normal tissues.
PAQUET, N.; HUSTINX, Roland ULiege; FOIDART-WILLEMS, Jacqueline ULiege

in European Journal of Nuclear Medicine and Molecular Imaging (2003), 30(SUPPL 2), 327

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See detailIntra-specific variation in nitrate tolerance in tadpoles of the Natterjack toad.
Miaud, C.; Oromi Farrús, Neus ULiege; Guerrero, S. et al

in Ecotoxicology (2011), 20

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See detailINTRA-TUMORAL HETEROGENEITY AND RATIONAL SELECTION OF ANTIGENS FOR TARGETED THERAPY OF LIVER METASTASES
Turtoi, Andrei ULiege; Blomme, Arnaud ULiege; Delvaux, David ULiege et al

in Acta Chirurgica Belgica (2012, May), 112(3), 8953

Objectives: Targeted therapies of liver metastases are gaining a major stake in current and future treatment options. However, the malignant lesions are heterogeneous in nature offering niches for cancer ... [more ▼]

Objectives: Targeted therapies of liver metastases are gaining a major stake in current and future treatment options. However, the malignant lesions are heterogeneous in nature offering niches for cancer cells causing treatment resistance and relapse. Therefore, a rational strategy is needed to select targetable antigens that would overcome this intra-tumoral heterogeneity. Methods: After ethical committee approval, 48 fresh liver metastases of colorectal origin were prospectively collected from patients undergoing liver resection. Here we macroscopically divided the lesion in different zones and generated a unique quantitative picture of the proteome heterogeneity in colorectal carcinoma liver metastases. Particular focus was laid on accessible proteins, a protein subclass comprising cell membrane associated and extracellular proteins. Accordingly, the tissues were ex-vivo biotinylated, affinity purified and analyzed for each zone separately using nano-UPLC-MSe proteomics technique. In total over 1500 unique proteins were statistically divided into different patterns of expression. Results: We have generated a quantitative picture of the proteome heterogeneity in colorectal carcinoma liver metastases. The study offers insight into novel targets but also antigens against which the antibodies are already involved in clinical trials or treatment of liver metastases. Extensive clustering and validation experiments highlight novel markers that offer the potential to homogeneously cover the metastatic lesion and become better targets. Conclusions: Two such antigens, LTBP2 and TGFBI were selected for functional analysis in colorectal carcinoma cells. In vitro and in vivo experiments showed that in particular TGFBI is relevant for migration and proliferation capacity of colorectal cancer cells. The suppression of this protein led to significant inhibition of tumor growth, crystalizing it as bona fide target for the development of anti-metastases therapies. [less ▲]

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See detailIntraarterial spiral CT angiography combined with DSA in pretherapeutic assessment of cerebral aneurysms.
Flandroy, P.; Vanderschelden, P.; Dondelinger, Robert ULiege et al

Conference (1996, September 21)

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See detailIntracanalar lumbar neurinoma
Manto, Florence; HOUET, Elise ULiege; LACREMANS, Pierre ULiege et al

in Abstract Book of Annual Congress of Physical & Rehabilitation Medicine 2016 (2016, December 09)

Neurinoma are slow growing encapsulated tumors, coming from Schwann cells. They are a rare cause of low back pain, possibly with a radiating pain in the inferior limb. This case report describes the ... [more ▼]

Neurinoma are slow growing encapsulated tumors, coming from Schwann cells. They are a rare cause of low back pain, possibly with a radiating pain in the inferior limb. This case report describes the managing of a patient with right cruralgia without strength lost. The CT- scan had failed to highlight a lesion corresponding to the symptoms of the patient. A MRI was therefore realized, and was able to show a lumbar intradural tumor. The MRI signal of neurinoma is usually typical. However, in this case, the histo-pathological analysis has been necessary to confirm the diagnosis. The patient underwent laminectomy and tumor resection with nearly complete resolution of symptoms, excepting a right perineal hemihypoesthesia, probably corresponding to the location of the concerned nervous root. The MRI is the best method to explore cruralgia or a sciatica not responding to treatment, and without precipitating factor such as disc herniation explaining the symptoms. [less ▲]

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See detailIntracardiac defect demonstrated by cardiac CTA.
Ghekiere, O.; Djekic, J.; NCHIMI LONGANG, Alain ULiege

in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2010), 93(2), 113

Detailed reference viewed: 15 (4 ULiège)