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See detail5-Fluorouracil degradation rate in patients with recurrent gastrointestinal cancer treated with metronomic capecitabine
Roberto, Michela; Romiti, Adriana; Lionetto, Luana et al

in Annals of Oncology (2015), 27(Suppl 2),

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See detail5-HT challenge in healthy vigile calves after MDL72222 pretreatment
Linden, Annick ULiege; Desmecht, Daniel ULiege; Rollin, Frédéric ULiege et al

in Pflügers Archiv : European Journal of Physiology (1994), 426

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See detailThe 5-HT1A agonism potential of substituted-piperazine-ethyl-amide derivatives is conserved in the hexyl homologues: molecular modeling and pharmacological evaluation
Dilly, Sébastien ULiege; Scuvée-Moreau, Jacqueline ULiege; Wouters, Johan et al

in Journal of Chemical Information & Modeling (2011), 51(11), 2961-2966

In a series of carboxamide and sulphonamide alkyl (ethyl to hexyl) piperazine analogues, although the size of the linker is very different, ethyl and hexyl derivatives possess a high affinity for 5-HT1A ... [more ▼]

In a series of carboxamide and sulphonamide alkyl (ethyl to hexyl) piperazine analogues, although the size of the linker is very different, ethyl and hexyl derivatives possess a high affinity for 5-HT1A receptors. Docking studies clearly show that hexyl and ethyl compounds favourably interact with the binding site of the active conformation of 5-HT1A receptors, thus confirming a possible agonist profile. This activity is effectively detected in electrophysiological experiments in which all four compounds inhibit the activity of rat dorsal raphe serotonergic neurons. [less ▲]

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See detail5-HT1A dysfunction in borderline personality disorder.
Hansenne, Michel ULiege; Pitchot, William ULiege; Pinto, Emmanuel ULiege et al

in Psychological Medicine (2002), 32(5), 935-41

BACKGROUND: A number of challenge studies have reported abnormalities of serotonergic function in borderline personality disorder (BPD). There are, however, problems with the pharmacological probes used ... [more ▼]

BACKGROUND: A number of challenge studies have reported abnormalities of serotonergic function in borderline personality disorder (BPD). There are, however, problems with the pharmacological probes used in these studies since fenfluramine and m-CPP are not only serotonergic agents but also induce release of catecholamines, particularly dopamine. Therefore, we tested whether subjects with BPD showed a blunted prolactin (PRL) response to flesinoxan, a highly potent and selective 5-HT1A agonist. METHODS: Flesinoxan challenge test was carried out in 20 BPD in-patients and 20 healthy controls matched for gender but not for age. Since 16 BPD in-patients exhibited major depressive co-morbidity, a group of 20 depressed in-patients matched for gender but not for age was also included. RESULTS: BPD in-patients exhibited blunted PRL responses as compared to controls, whereas depressed in-patients did not differ from controls. Moreover, PRL responses were lower among BPD in-patients than among depressed in-patients. Among the BPD in-patients, PRL responses to flesinoxan were lower in patients with past history of suicide attempts (N = 8) than in those with a negative history. CONCLUSIONS: The results show major involvement of serotonergic function in BPD and are consistent with previous studies linking lower serotonergic activity with impulsivity. More particularly, our data suggest that BPD is characterized by lower 5-HT1A receptor sensitivity. Moreover, the data support the involvement of 5-HT1A activity in suicidal behaviour. However, this conclusion is limited because other hormonal responses such as ACTH and cortisol were not assessed, and because BPD was assessed by a self-report questionnaire and not a structured clinical interview. [less ▲]

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See detail5-HT1A receptor distribution in the human brain: preliminary PET data with p-[18F]MPPF.
Fuchs, Sonia ULiege; Plenevaux, Alain ULiege; Degueldre, Christian ULiege et al

in Society for Neuroscience / Abstracts (1999), 25

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See detail5-HT1A Receptors visualization with p-[18F]MPPF in healthy volunteers.
Plenevaux, Alain ULiege; Lemaire, Christian ULiege; Salmon, Eric ULiege et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1999), 42

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See detail5-HT2A receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner
Liégeois, Jean-François ULiege; Ichikawa, J.; Meltzer, H. Y.

in Brain Research (2002), 947(2), 157-165

Combined serotonin (5-HT)(2A) and dopamine (DA) D-2 blockade has been shown to contribute to the ability of atypical antipsychotic drugs (APDs) to increase DA release in rat medial prefrontal cortex (mPFC ... [more ▼]

Combined serotonin (5-HT)(2A) and dopamine (DA) D-2 blockade has been shown to contribute to the ability of atypical antipsychotic drugs (APDs) to increase DA release in rat medial prefrontal cortex (mPFC). We provide additional support for this hypothesis by examining the effect of the selective 5-HT2A antagonist M100907 plus haloperidol, a potent D, antagonist APD, on DA release in the mPFC and nucleus accumbens (NAC). Haloperidol (0.01-1.0 mg/kg) produced an inverted U-shaped increase in DA release in the mPFC, with a significant increase only at 0.1 mg/kg. Haloperidol (0.1 and 1.0 mg/kg) significantly increased DA release in the NAC. M100907 (0.1 mg/kg) by itself had no effect on DA release in either region. This dose of M100907 potentiated the ability of low (0.01-0.1 mg/kg), but not high dose (0.3-1.0 mg/kg) haloperidol to increase mPFC DA release, whereas it abolished the effect of both 0.1 and 1.0 mg/ka haloperidol on NAC DA release. These results suggest that the relatively higher ratio of 5-HT2A to D-2 antagonism may contribute to the potentiation of haloperidol-induced mPFC DA release, whereas 5-HT2A antagonism can diminish haloperidol-induced NAC DA release, even when combined with extensive D, antagonism, which may not be synergistic with 5-HT2A antagonism in the mPFC. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detail5-HT2A receptor polymorphism gene in Bipolar Patients and Harm Avoidance personality trait
Blairy, Sylvie ULiege; Massat, I; Staner, L et al

in American Journal of Medical Genetics Part B-Neuropsychiatric Genetics (2000), 96(3), 360-364

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See detail5-Hydroxytryptamine 1A receptors, major depression, and suicidal behavior.
Pitchot, William ULiege; Hansenne, Michel ULiege; Pinto, Emmanuel ULiege et al

in Biological Psychiatry (2005), 58(11), 854-8

BACKGROUND: Several lines of evidence suggest a clear relationship between serotonin (5-hydroxytryptamine, 5-HT) hypoactivity and suicidal behavior across several psychiatric diagnoses. Few data are ... [more ▼]

BACKGROUND: Several lines of evidence suggest a clear relationship between serotonin (5-hydroxytryptamine, 5-HT) hypoactivity and suicidal behavior across several psychiatric diagnoses. Few data are available, however, regarding the possible specific role of 5-HT1A receptors in the biology of suicidality. Therefore, the aim of our study was to use a neuroendocrine strategy to test the hypothesis of a role for 5-HT1A receptors in the biology of suicidal behavior. METHODS: Hormonal (adrenocorticotropic hormone [ACTH], cortisol, prolactin [PRL]) and temperature responses after administration of flesinoxan, a highly potent and selective 5-HT1A receptor full agonist, were assessed in 40 inpatients with major depression, divided into two subgroups (20 suicide attempters and 20 nonattempters), compared with 20 normal control subjects matched for gender and age. RESULTS: Compared with nonattempters, suicide attempters exhibited significantly lower PRL (p = .01), cortisol (p = .014), and temperature (p = .0002) responses. Prolactin (p = .007), cortisol (p = .04), and temperature (p = .00003) responses were also decreased in suicide attempters compared with normal control subjects. In contrast, we did not observe any significant differences in hormonal or temperature responses to flesinoxan between depressed patients without a history of suicide attempt and normal control subjects. CONCLUSIONS: The present study tends to confirm the role of 5-HT and more specifically 5-HT1A receptors in the biology of suicidal behavior in major depression. [less ▲]

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See detail5-Nucleotidase activity in isolated follicular dendritic cells.
Heinen, Ernst ULiege; Kinet-Denoel, C.; Simar, L. J.

in Immunology Letters (1985), 9(2-3), 75-80

Follicular dendritic cells isolated from mouse lymph nodes were incubated in the presence of AMP to test 5-nucleotidase (5-Nase) activity. Ultrastructural observations showed the presence of 5-Nase on ... [more ▼]

Follicular dendritic cells isolated from mouse lymph nodes were incubated in the presence of AMP to test 5-nucleotidase (5-Nase) activity. Ultrastructural observations showed the presence of 5-Nase on external membranes but also some activity inside the nucleus. 5-Nase was found associated to Fc receptors labelled with homologous immunoglobulins fixed on colloidal gold particles. Lymphocytes and macrophages, found in association with the follicular dendritic cells, were either 5-Nase positive or negative. The hypothetical roles played by 5-Nase in germinal centers are discussed. [less ▲]

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See detail5-Phenylacetylaminothiazolium salts and their reactions with nucleophiles
Pirotte, Bernard ULiege; Delarge, J.

in Journal of Chemical Research (S) (1990)

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See detailA 5-Year Controlled Randomized Study of Prevention of Postmenopausal Trabecular Bone Loss with Nasal Salmon Calcitonin and Calcium
Reginster, Jean-Yves ULiege; Meurmans, L.; Deroisy, Rita ULiege et al

in European Journal of Clinical Investigation (1994), 24(8), 565-9

The aim of this paper was to evaluate the long-term (5 years) efficacy of nasal salmon calcitonin in prevention of trabecular postmenopausal bone loss, which was a follow-up of a previously published ... [more ▼]

The aim of this paper was to evaluate the long-term (5 years) efficacy of nasal salmon calcitonin in prevention of trabecular postmenopausal bone loss, which was a follow-up of a previously published study (3 years); a randomized, controlled group comparison. One hundred healthy postmenopausal women were randomly chosen from those (186) having completed the 3 year protocol. The 100 women were allocated to an additional 2 year period (total of 5 years) of treatment with either 500 mg d-1, 5 days week-1 of calcium or the same amount of calcium plus 50 IU d-1, 5 days per week of nasal salmon calcitonin, 87 (87%) women complied with the protocol throughout. The main outcome measures were the bone mineral density of the lumbar spine (1-BMD) (DPA) and biochemical parameters reflecting bone turnover (serum alkaline phosphatases, urinary calcium/creatinine and hydroxyproline/creatinine ratios). The women receiving calcium alone presented a significant decrease in 1-BMD after 6 months [-1.6 (0.5)%] [mean(SEM)] (P < 0.01) and this decrease remained significant after 36 months [-6.1(0.8)%] (P < 0.01) and until the end of the trial [-6.6(1.0)% at t60] (P < 0.01). In women receiving calcium and calcitonin, 1-BMD significantly increased after 36 months [+2(0.7%] (P < 0.01) and 42 months [+2.5(0.7)%] (P < 0.01 and was unchanged at the other times of investigation [+1.1 (1.1)% at t60] (NS). The evolution of BMD in the two groups was highly significantly different (P < 0.001) since the sixth month of the study and remained so until the end of the study.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailA 5-year survey of dermatophytes strains circulating in Belgium
SACHELI, Rosalie ULiege; DARFOUF, Rajae ULiege; ADJETEY BAHUN, Akolé ULiege et al

Poster (2017, October)

Objectives Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. They are the most common cause of superficial fungal infections worldwide ... [more ▼]

Objectives Dermatophytosis refers to superficial fungal infections of keratinized tissues caused by keratinophilic dermatophytes. They are the most common cause of superficial fungal infections worldwide. Epidemiological studies regarding dermatophytes infections have been conducted in several countries and differences in the incidence and in etiological agents have been reported. That is why national surveillance of circulating strains causing dermatophytosis is critical. The National Reference Center (NRC) for mycoses conducted a survey on dermatophytes strains circulating in Belgium from 2012 to 2016. The present study was performed to assess the profile of dermatophytosis and to identify the species involved. Methods The Belgian NRC for mycoses (Leuven and Liège) collected 14227 strains between January 2012 and December 2016. The strains were obtained from clinically suspected fungal infections of skin, hair and nails. Strains were collected from Belgian laboratories in order to confirm the fungal identification which was performed by microscopy and in case of doubt by ITS sequencing. Results Among the 14227 samples collected, 6248 were identified as dermatophytes (44%). Trichophyton rubrum was the most prevalent species accounting for 61,3% (n=3820) of the strains collected from all sources, followed by T. mentagrophytes complex (19,2%, n=1199) according to the ancient classification (including T. interdigitale, T. benhamiae and T. mentagrophytes). Other less prevalent species were also recorded: M. audouinii (n=507, 8,1%), M. canis (n=210, 3,3%), T. tonsurans (n= 140, 2,2%), T. violaceum (n=133, 2,1%), T. soudanense (n=125, 2%), M. praecox (n=60, 0,96%) and E. floccosum (n=19, 0,3%) for the main ones. Our data show the predominance of anthropophilic species causing tinea capitis especially M. audouinii responsible for 43,4% (n=303/716) of hair/scalp infection with an increasing number from 2014 to 2016. Trichophyton soudanense, rarely observed in Belgium in the past, is an emerging agent of tinea capitis particularly since 2013, accounting for 11,3% (n=81) of the cases during the 5-year study period. Zoophilic strains such as M. canis which were well represented in the past epidemiology of tinea capitis are decreasing accounting for only 8,8% (n=63) of hair/scalp infection. Finally, our data confirm the high prevalence of T. rubrum as the main etiologic agent of onychomycosis (78,1%, n=3094/3968) followed by T. mentagrophytes complex (18,8%, n=743/3968). Both latter strains were also responsible for the majority of skin infections as they were isolated respectively in 46,2% (n=693/1612) and 21,7% (n=348/1612) of skin samples. Conclusions The present epidemiological survey provides recent data on the prevalence of all dermatophytes circulating in Belgium. Analyzing such data is critical for the establishment of measures for prevention and control of dermatophytes infections. Our study confirms the predominance of T. rubrum followed by species from the ancient T. mentagrophytes complex (T. interdigitale + T. benhamiae) in the Belgian population. This survey highlights also the persistent predominance of M. audouinii and the emergence of T. soudanense as causative agents of tinea capitis. [less ▲]

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See detail5. Action research: an essential approach for constructing the development of sustainable urban agricultural systems.
Bousbaine, Antonia ULiege; Bryant, christopher

in Challenge in Sustainability (2016), 4 (1)

How can research contribute more directly to promoting and leading to sustainable solutions and projects? This article suggests that one of the most important research approaches capable of achieving this ... [more ▼]

How can research contribute more directly to promoting and leading to sustainable solutions and projects? This article suggests that one of the most important research approaches capable of achieving this is the Action Research approach. This involves the researcher taking on a number of roles when working with other actors (e.g. citizens, farmers, local elected officials, citizen associations, government representatives. . . with the specific set of actors depending upon the nature of the subject being investigated and for which solutions are sought). The roles that the researcher can play involve providing appropriate information to the other actors, providing counseling to them, organizing and animating meetings with the actors, and accompanying the whole process involving all the actors. These roles are essentially played out by the researcher when the other actors request the researcher to assume whichever roles they consider to be significant. The fundamental notion is that through this process the actors appropriate the sustainable solutions as their own, and the researcher helps them achieve this. This article is based on: a) a synthesis of pertinent research using the Action Research approach (specifically in relation to sustainable agricultural systems in periurban territories), and b) specific research undertaken by the two co-authors of the article, all in the context of periurban agricultural systems during the last 8 years, as well as on some of their publications. The necessary characteristics of Action Research and the researchers involved are identified, namely: a) patience; b) an emphasis on process; and c) an emphasis on participation on the part of multiple actors [less ▲]

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See detail5. Le smorfie del ghiaccio che si sgretola: Il montalismo di Fabio Pusterla
Benzoni, Pietro ULiege

in Stilistica e metrica italiana (2005), V(5), 267-303

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See detail5. « Qu’est-ce qu’un signe linguistique? Le revers psychologique de la théorie husserlienne des actes de signification à l’époque des Recherches logiques »
Gyemant, Maria ULiege

in INVESTIGACIONES FENOMENOLÓGICAS REVISTA DE LA SOCIEDAD ESPAÑOLA DE FENOMENOLOGÍA (2013), 4(1), 219-234

Dans le § 8 de la 1ère recherche logique Husserl explique qu'est-ce que c'est l'expression (Ausdruck), par opposition à un autre type de signe: l'indice (Anzeichen). Ce qu'est en jeu, c'est la spécificité ... [more ▼]

Dans le § 8 de la 1ère recherche logique Husserl explique qu'est-ce que c'est l'expression (Ausdruck), par opposition à un autre type de signe: l'indice (Anzeichen). Ce qu'est en jeu, c'est la spécificité de l'expression, entendue par Husserl comme une sorte de signe qui présente un caractère clair. Mais afin de determiner l'expression Husserl effectue une opération interpretée par Derrida comme un premier type de réduction: réduction du langage a une forme du soliloque. En d'autres termes, au moment où Husserl doit expliquer ce qu'est un signe linguistique, met entre parenthèses précisément la fonction symbolique des expressions. Je tiens à souligner dans cet article les raisons qui conduisent Husserl à ce surprenant geste de mettre entre parenthèses l'une des fonctions les plus essentielles des actes significatifs, la fonction comunicative de contenus intentionnels au moyen de signes dans un contexte intersubjectif. Je montrerai après ce que conduit Husserl à examiner à nouveau cette décision et à la critiquer dans les textes de 1913-1914 lors de la préparation de la deuxième édition des Recherches logiques et publiés aujourd'hui dans le volume XX/2 de Husserliana. [less ▲]

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See detail5. Froment 2015: Enfin une récolte sereine
Sinnaeve, Georges; Gofflot, S.; Chandelier, Anne et al

in Bodson, Bernard; Watillon, Bernard (Eds.) Livre Blanc Céréales (2015, September 10)

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See detail5. Froment 2016: une récolte médiocre qui sera difficile à valoriser
Sinnaeve, Georges; Gofflot, S.; Chandelier, A. et al

in Bodson, Bernard; Watillon, Bernard (Eds.) Livre Blanc Céréales (2016, September 08)

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See detail5. Froment 2017: une récolte hâtive et étalée avec une qualité moyenne
Sinnaeve, Georges; Gofflot, Sébastien; Chandelier, Anne et al

in Bodson, Bernard; Watillon, Bernard (Eds.) Livre Blanc Céréales (2017, September 14)

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