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See detailImplication de la transition épithélio-mésenchymateuse dans la progression métastatique des cellules tumorales mammaires.
Gilles, Christine ULiege; Mestdagt, M; Bindels, S et al

Conference (2006, June 08)

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See detailImplication des cellules Natural Killer (NK) dans le développement des lésions associées à l'infection par les papillomavirus humains (HPV)
Renoux, Virginie ULiege

Doctoral thesis (2011)

Persistent infections with high-risk papillomavirus (HPV) are associated with more than 25% of cancers induced by infectious agents. Nevertheless, the two vaccines preventing HPV infection have no ... [more ▼]

Persistent infections with high-risk papillomavirus (HPV) are associated with more than 25% of cancers induced by infectious agents. Nevertheless, the two vaccines preventing HPV infection have no therapeutic efficacy and it has been estimated that there will be no measurable decline of HPV-associated tumours before 2040. The immune system is able to control, at least partially, HPV infection and subsequent tumour development. Around 90% of HPV-infected women will clear the virus within two years, but the immune effectors responsible for this viral clearance are unknown. Hence, the aim of this study was to determine if Natural Killer (NK) cells could play a role in the immune response against HPV infection and related cancers. The first part of this work was focused on the in vitro interaction of NK cells with L1 and L1L2 Virus Like Particles (VLP) of HPV16. We observed that, in the presence of HPV-VLP, NK cells displayed a higher cytotoxic activity against HPV+ cells by increasing the exocytosis of their cytotoxic granules and by secreting TNF-α and IFN-γ. NK cell activation was correlated with a fast entry of HPV-VLP by macropinocytosis and we determined that cell surface CD16 expression was necessary for HPV internalization, but also for degranulation and cytokine production. In the second part, to understand the molecular mechanisms of HPV-VLP stimulation, we investigated the signalling pathways operating in NK cells to trigger their cytotoxic activity in the presence of viral particles. We observed that the MAP kinases ERK and p38 were phosphorylated in the presence of both L1 and L1L2 HPV-VLP. Using specific inhibitors, we demonstrated that phosphorylation of these MAPK was required for degranulation and cytokine secretion by NK cells in the presence of VLP. In conclusion, NK cell activity could be an important player in the immune response contributing to viral clearance and to regression of HPV-induced cervical lesions. [less ▲]

Detailed reference viewed: 103 (26 ULiège)
See detailImplication des hormones de croissance et du système CD95/CD95-ligand dans la tolérance fœto-placentaire
Thellin, Olivier ULiege

Doctoral thesis (1999)

We attempted here to contribute to the study of 2 hypothesis concerning mechanisms implicated in the foeto-tolerance phenomenon. The first hypothesis concerned the potential effects of the replacement of ... [more ▼]

We attempted here to contribute to the study of 2 hypothesis concerning mechanisms implicated in the foeto-tolerance phenomenon. The first hypothesis concerned the potential effects of the replacement of the pituitary growth hormone (hGH-N) by the placental growth hormone (hPGH) on the maternal immune system. We mainly performed a preliminary study of these effects in the man and in the non-pregnant woman in order to transpose the obtained results to the pregnant woman. We have also analyzed the expression of the hGH-N receptor, which can be bound by both hGH-N and hPGH, on the surface of a wide variety of cell types and sub-types, activated or not, which had never been done in a single study before. We showed notably that, among the stydied cell types, the expression of hGH-N-R was mainly performed by activated T cells, by activated or non-activated B cells and by monocytes. Lowly differentiated cells could express more hGH-N-R, which is supported by published data suggesting that immature cells (hematopoietic bone marrow and thymus) are particularly sensitive to hGH-N. However, the activation of lymphoid cells, mainly T lymphocytes, by mitogens increases the expression of hGH-N-R. The comparative study of the effects of hGH-N and hPGH on cells from the human immune system had never been performed before. Our tests performed by the introduction of growth hormones at physiological concentrations in the culture medium of lymphoif cells indicates that their effect on the cell proliferation is equivalent. [less ▲]

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See detailImplication des intolérances et allergies alimentaires dans le syndrome du côlon irritable: quelles sont les evidences?
Ausloos, Floriane ULiege; Belaiche, Jacques ULiege; Louis, Edouard ULiege

in Revue Médicale de Liège (2005), 60(9), 744-9

Irritable Bowel Syndrome (IBS) is a complex and heterogeneous entity that concerns about 1/4 of adults and would be responsible for 50% of gastro-enterology medical consultations. IBS etiopathogenesis and ... [more ▼]

Irritable Bowel Syndrome (IBS) is a complex and heterogeneous entity that concerns about 1/4 of adults and would be responsible for 50% of gastro-enterology medical consultations. IBS etiopathogenesis and physiopathology are not yet fully known. [less ▲]

Detailed reference viewed: 105 (9 ULiège)
See detailImplication des mécanismes d’apprentissage de régularités dans l’acquisition du langage chez l’enfant sain et dysphasique
Gabriel, Audrey ULiege; Urbain, Charline

in C. Maillart, M.-A. Schelstraete (Ed.) Les dysphasies : de l’évaluation à la rééducation (2012)

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See detailL'implication des médecins généralistes dans la gestion des abus de substances
Ketterer, Frédéric ULiege; Symons, Linda; Lambrechts, Marie-Claire et al

Conference (2014, November 28)

Introduction : Les médecins généralistes jouent un rôle majeur dans la détection et la gestion des abus de substances. L'étude présentée ici investiguait les facteurs qui influencent leur implication ... [more ▼]

Introduction : Les médecins généralistes jouent un rôle majeur dans la détection et la gestion des abus de substances. L'étude présentée ici investiguait les facteurs qui influencent leur implication concernant la gestion des abus d'alcool, des drogues illégales, des hypnotiques et des anxiolytiques dans la population belge des 18-65 ans. Méthode : 20 MG ont été interrogés par entretiens semi-directifs. Le I-Change Model de de Vries a été utilisé pour construire le guide d'entretien et analyser les données récoltées. Il s'agit d'un modèle de prédiction du comportement. Résultats : Parmi les principaux résultats de l'étude, il ressortait que les MG étaient fortement influencés dans leur approche par leurs propres représentations de l'abus, qui oscillait leurs responsabilités professionnelles envers ces patients et la responsabilité de ces derniers quant à la gestion de leur santé, avec l'idée de faute morale en substrat. En ce sens, l'abus de substance était perçu sur un continuum entre l'abus comme forme de maladie chronique d'une part, et la faute morale d'autre part. L'alcool et le cannabis étaient néanmoins mieux acceptés socialement que les autres substances. Les propres expériences personnelles des généralistes concernant les abus avaient aussi une incidence sur leur volonté de s'investir avec ces patients. Pour autant, les pratiques multidisciplinaires (notamment au forfait) et l'expérience étaient évoquées comme des facteurs importants quant à l'engagement dans la gestion. Les contraintes temporelles et l'investissement demandé étaient, en revanche, considérés comme des barrières. Discussion : Les facteurs motivationnels apparaissaient centraux dans la décision de s'investir dans la gestion des abus de substances, bien davantage que les connaissances théoriques et les formations qui semblaient plus secondaires. La peur du burnout s'exprimait donc en substrat. La formation des MG devrait tenir compte de ce souhait de se protéger, afin de favoriser simultanément une approche centrée sur le patient. [less ▲]

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See detailImplication des métalloprot́eases matricielles en obśtetrique: De la nidatiòn a l'accouchement
Christiane, Yolande; Emonard, Violaine ULiege; Emonard, Herve

in Revue Médicale de Liège (2014), 69(1), 46-50

Matrix metalloproteases, which remodel the extracellular matrix, are involved in all physiological and pathophysiological processes. In particular, they contribute to the success of a pregnancy : from ... [more ▼]

Matrix metalloproteases, which remodel the extracellular matrix, are involved in all physiological and pathophysiological processes. In particular, they contribute to the success of a pregnancy : from embryo implantation in the endometrium to uterine cervical ripening and uterine involution. A misregulation of their expression and/or of their activity is observed in two major diseases in pregnancy such as spontaneous abortion and preeclampsia. [less ▲]

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See detailImplication des modifications épigénétiques dans les cancers : développement de nouvelles approches thérapeutiques
Vandermeers, Fabian ULiege; Kettmann, Richard ULiege; Willems, Luc ULiege

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2008), 12(2),

Involvement of epigenetic modifications in cancers: development of new therapeutic approaches. Since cancer is the second cause of death after cardiovascular diseases in industrialized countries, it is ... [more ▼]

Involvement of epigenetic modifications in cancers: development of new therapeutic approaches. Since cancer is the second cause of death after cardiovascular diseases in industrialized countries, it is urgent to elaborate new therapeutic approaches. Besides DNA mutations of essential genes, expansion of a cancer cell is frequently associated with epigenetic modifications i.e. not directly coded by the DNA sequence. Amongst epigenetic modifications, histones acetylation and DNA methylation are known to play important roles. In this context, a very promising anticancer therapy would be to correct epigenetic errors using compounds modulating histone acetylation and DNA methylation alone or in combination with other chemotherapeutic agents. [less ▲]

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See detailImplication des papillomavirus humains dans les cancers des voies aérodigestives supérieures
Neufcoeur, P. E.; Arafa, Mohammad Mahmoud Mohammad ULiege; Delvenne, Philippe ULiege et al

in Bulletin du Cancer (2009), 96(9), 1-10

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See detailL'implication des parties prenantes comme un processus de construction sociale. analyse à partir de la théorie de l'acteur-réseau
El Abboubi, Manal ULiege; Cornet, Annie ULiege

in Revue Management et Avenir [= RMA] (2010), 33(2010/3), 275297

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See detailImplication des propriétés biomécaniques des muscles transformés dans le mécanisme de la cardiomyoplastie
Radermacker, M. A.; Sluse, Francis ULiege; Focant, B. et al

in Journal of Cardiology (1999), 9

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See detailImplication des troubles métaboliques dans la progression radiologique de la gonarthrose : analyse post-hoc issue de l'essai randomisé SEKOIA
Eymard, F; Parsons, C; Edwards, M et al

in Revue du Rhumatisme (2014), 81(Suppl. 1), 92

Detailed reference viewed: 26 (3 ULiège)
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See detailL'implication des utilisateurs dans les projets informatiques: un scénario en quête d’acteurs
Agro, Linda ULiege; Cornet, Annie ULiege; Pichault, François ULiege

in Annales des Mines: Gérer et Comprendre (1995), 41(décembre), 33-44

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See detailImplication for the use of benthic foraminifera as bio-indicators of pollution: The case study of the Northern coast of Sfax (South eastern Tunisia)
Lamourou, Ali ULiege; Touir, Jamel; Fagel, Nathalie ULiege

in YNHM 4TH YOUNG NATURAL HISTORY SCIENTISTS' MEETING (2017, February 12)

The use of foraminifers as bioindicators of pollution in coastal and paralic environments has undergone a very fast development. Among various criteria, morphological anomalies are sometimes considered as ... [more ▼]

The use of foraminifers as bioindicators of pollution in coastal and paralic environments has undergone a very fast development. Among various criteria, morphological anomalies are sometimes considered as pollution indicators. This paper presents a synthesis of the studies correlating foraminiferal assemblages and environmental concerns. Sediment cores retrieved along the northern coast of Sfax (Tunisia) are used to monitor the response of benthic foraminifera to modern pollution and environmental stress. Sediment samples were separated immediately after collection for benthic foraminifera analysis. Binocular microscope and the Scanning Electron Microscope (SEM) were carried out to identify the most significant, normal or deformed, specimens. All observations confirmed that foraminifera may be used as indicators of pollution after deconvoluting from natural impacts. The most sensitive foraminifera identified in the study area are Ammonia tepida, Ammonia beccarii, Elphidium crispum, Peneroplis pertususles Miliolidae, Peneroplis pertusus et Rosalina sp and Peneroplis planatus. The morphological study of benthic foraminifera from surface sediments attests for the pollution of the actual coast. This pollution is recorded in the benthic foraminifera tests mainly as shell deformations, chambers or streaks or abnormal colors. [less ▲]

Detailed reference viewed: 141 (17 ULiège)