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See detailIgE controlling loci in Czech atopic patients.
Gusareva, Elena ULiege; Havelková, Helena; Blažková, Hanna et al

Poster (2006, September 07)

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See detailIgE mediated sensitisation to aeroallergens in an asthmatic cohort: relationship with inflammatory phenotypes and disease severity.
Manise, Maïté ULiege; Bakayoko, B.; SCHLEICH, FLorence ULiege et al

in International Journal of Clinical Practice (2016), 70(7), 596-605

BACKGROUND: Atopy is known to play an important role in the asthmatic disease. The main objective of this study was to evaluate the frequency of sensitisation to common aeroallergens in a cohort of ... [more ▼]

BACKGROUND: Atopy is known to play an important role in the asthmatic disease. The main objective of this study was to evaluate the frequency of sensitisation to common aeroallergens in a cohort of asthmatics with different inflammatory phenotypes and disease severity. METHODS: We have conducted a retrospective cross-sectional study including 772 asthmatics recruited between 2003 and 2014 in our Asthma Clinic. The patients were defined as asthmatics on the basis of respiratory symptoms together with a positive methacholine test (PC20M) < 16 mg/ml and/or a reversibility to short-acting beta2-agonists (salbutamol) >/= 12% and 200 ml. Sensitisation to house dust mites, grass and birch pollens, cats, dogs and moulds was assessed by RAST and a specific immunoglobulin E (IgE) > 0.35 kU/l was considered as significant. Inflammatory phenotypes were subdivided between pauci-granulocytic (n = 309) (40%), eosinophilic (n = 311) (40%), neutrophilic (N = 134) (17%) and mixed-granulocytic (N = 18) (3%) asthmatics. Severe asthmatics (n = 118) were defined according to the American Thoracic Society (ATS 2000) criteria and compared with mild-to-moderate asthmatics (N = 654). RESULTS: The eosinophilic phenotype was associated with higher levels of total serum IgE compared with neutrophilic and pauci-granulocytic asthma (p < 0.001 for both). Sensitisation rate to dogs and cats was higher in eosinophilic asthmatics (31% and 37%, respectively, p < 0.01 both) compared with neutrophilic (18% and 23% respectively) and pauci-granulocytic asthmatics (20% and 24%, respectively), while sensitisation rate to house dust mites and moulds were rather similar between the groups (ranging from 33% to 40% and from 10% to 16%, respectively). Severe asthmatics had slightly increased total serum IgE compared with mild-to-moderate asthmatics (p < 0.05) without any difference in the sensitisation rate to common aeroallergens. CONCLUSION: Eosinophilic asthma exhibits higher total serum IgE and sensitisation rate towards animal dander while clinical severity, though also associated with higher total IgE, did not preferentially relate to any type of common aeroallergens. [less ▲]

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See detailIgE-mediated anaphylaxis after first intravenous infusion of cyclosporine.
Ebo, D. G.; Piel, Géraldine ULiege; Conraads, V. et al

in Annals of Allergy, Asthma & Immunology (2001), 87(3), 243-5

BACKGROUND: Intravenous administration of cyclosporine, which contains Cremophor EL (a polyethoxylated castor oil; BASF, Berlin, Germany), has occasionally resulted in an anaphylactic reaction. An ... [more ▼]

BACKGROUND: Intravenous administration of cyclosporine, which contains Cremophor EL (a polyethoxylated castor oil; BASF, Berlin, Germany), has occasionally resulted in an anaphylactic reaction. An apparent hypersensitivity reaction (bronchospasm and decrease in blood pressure) had occurred during heart transplantation in a 59-year-old woman after intravenous infusion of cyclosporine. Subsequent oral administration of cyclosporine precipitated no reaction. OBJECTIVE: The purpose of this study was to attempt to ascertain the mechanism responsible for the anaphylactic reaction. METHODS: Hypersensitivity investigations, including total serum IgE and allergen-specific IgE quantifications, skin testing, and basophil activation tests by flow cytometric determination of CD63 upregulation were undertaken in the study patient and in two healthy control subjects who were free of medication. RESULTS: The results of intradermal testing with Cremophor EL were positive after 15 minutes in the study patient only. Both cyclosporine and Cremophor EL induced considerable activation of the basophils from our study patient, with an upregulation of CD63 expression from 1% to 39% and 55%, respectively. In contrast, the expression of CD63 on basophils from the two control subjects remained essentially unchanged. CONCLUSIONS: The negative investigative findings in the control subjects, the patient's clinical manifestations in temporal relationship to the infusion, her positive results on intradermal testing with Cremophor, the basophil activation test results, and her uneventful course after oral administration of cyclosporine strongly support the presence of IgE antibodies to Cremophor EL in our patient. [less ▲]

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See detailThe IGF system in in-vitro human decidualization
Ganeff, Corinne ULiege; Chatel, G.; Munaut, Carine ULiege et al

in Molecular Human Reproduction (2009), 15(1), 27-38

Decidualization of endometrial stromal cells (ESCs) is critical for a successful pregnancy but the molecular mechanisms of the process are poorly understood. In this study, we investigated whether the ... [more ▼]

Decidualization of endometrial stromal cells (ESCs) is critical for a successful pregnancy but the molecular mechanisms of the process are poorly understood. In this study, we investigated whether the insulin-like growth factor (IGF) network is involved in this cellular process. Expression kinetics of members of the IGF system was examined at both mRNA and protein levels during in-vitro decidualization of cultured human ESCs. We found a significant up-regulation of IGF-II as well as of IGF-I receptor and the A and B insulin receptor (InsR) isoforms. In addition, levels of the key adaptor proteins insulin receptor substrate 1 (IRS-1) and IRS-2 increased, suggesting a potential involvement of the IGF signalling pathway in the decidualization process. Expression of two IGF binding proteins, IGFBP-1 and IGFBP-4, which can inhibit IGF action, also increased. In order to determine whether IGF signalling was activated during decidualization, the phosphorylation status of the receptors and the adaptor proteins was estimated. Only IRS-2 was slightly phosphorylated in decidualized cells and was further activated by the addition of exogenous IGF-II. These results suggest that the IGF signalling pathway could play a crucial role in the functions of decidualized endometrial cells [less ▲]

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See detailIGF-1 but not IL-1bêta effects on the proteoglycan production by chondrocytes are regulated by strontium salts
Henrotin, Yves ULiege; Labasse, A; Zheng, X et al

in Osteoarthritis and Cartilage (1997), 5

Detailed reference viewed: 13 (4 ULiège)
Peer Reviewed
See detailIGF-I and IGFBP-3 increase independently of testosterone release during the onset of puberty in cattle
Renaville, Robert ULiege; Sneyers, Myriam; Massart, Serge et al

in Growth Regulation (1994), 4(suppl 1), 116

Detailed reference viewed: 12 (2 ULiège)
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See detailIGF-I and IGFBP-3 increase independently of testosterone release during the onset of puberty in cattle.
Renaville, Robert ULiege; Sneyers, Myriam; Massart, Serge et al

Poster (1994)

Detailed reference viewed: 11 (1 ULiège)
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See detailIGF-I and IGFBPs in plasma of growing Landrace and large withe pigs.
Messina, M.; Prandi, A.; Nicolas, Nathalie et al

in Proceedings of the 14th IPVS Congress (1996, July)

Detailed reference viewed: 8 (0 ULiège)
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See detailIGF-I and IGFBPs in plasma of growing Landrace and Largewhite pigs
Messina, Maria; Prandi, Alberto; Kettmann, Richard ULiege et al

in 14th International Pig Veterinary Society Congress (1995)

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See detailIGF-I and their binding proteins in growing horses
Gerin, Daniele; Messina, Maria; Renaville, Robert ULiege et al

in 3° Internat. Conf. farm Anim. Endocrinol. (1998)

Detailed reference viewed: 4 (0 ULiège)
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See detailIGF-I and their binding proteins in growing horses.
Gerin, Daniele; Messina, Mariella; Renaville, Robert ULiege et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1998), 2(special issue), 34

Detailed reference viewed: 15 (1 ULiège)
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See detailIGF-I, IGFBP-2 and IGFBP-3 but not GH consentrations are different in normal and poor growing piglets
Saleri, Roberta; Baratta, Mario; Mainardi, G. L. et al

in Reproduction Nutrition Development (2001), 41

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See detailIGF-II in primary human colorectal tumors: peptide level, activated promoters, parental imprinting and gene rearrangement.
Winkler, Rose ULiege; Delacroix, Laurence ULiege; Bensbaho, K. et al

in Hormone & Metabolic Research (1999), 31(2-3), 148-54

IGF-II is a polypeptide growth factor with growth and differentiation promoting activities, involved in human development. We have reported previously IGF-II mRNA and peptide overexpression in primary ... [more ▼]

IGF-II is a polypeptide growth factor with growth and differentiation promoting activities, involved in human development. We have reported previously IGF-II mRNA and peptide overexpression in primary human colon cancers. Here we show that the IGF-II peptide content is increased in six primary colon cancers compared to the corresponding healthy tissues. The IGF-II transcripts in healthy and cancerous colon tissues were identified by Northern blotting and RT-PCR. Promoters P3 and P4 were active in most tissues. Relaxation of parental imprinting was observed in two tumors and one healthy tissue, without any correlation with the IGF-II transcript levels. Rearrangements of the IGF-II gene in two tumors containing very high amounts of IGF-II mRNA are described. Fragments containing the breakpoints were cloned by the vectorette-PCR strategy. In both tumors, the breakpoints occurred in repetitive sequences. In one tumor (T11), the breakpoint was localized 2 kb downstream the end of exon 9. The second tumor (T18) contains two modified alleles. In one rearranged allele the breakpoint is located in exon 9. The exact position of the breakpoint in the second rearranged allele has not been identified. In future experiments, the correlation between the gene rearrangements and IGF-II mRNA overexpression will be studied. [less ▲]

Detailed reference viewed: 10 (1 ULiège)
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See detailIgf2 expression is required for complete immunological tolerance to insulin
Hansenne, Isabelle; Renard, Chantal; Geenen, Vincent ULiege

Poster (2007, July)

Detailed reference viewed: 19 (8 ULiège)
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See detailIGFBP2 sérique comme nouveau marqueur de la fibrose pulmonaire idiopathique
GUIOT, Julien ULiege

Conference (2016)

Detailed reference viewed: 50 (18 ULiège)
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See detailIgG fc receptors provide an alternative infection route for murine gamma-herpesvirus-68.
Rosa, Gustavo T; Gillet, Laurent ULiege; Smith, Christopher M et al

in PLoS ONE (2007), 2(6), 560

BACKGROUND: Herpesviruses can be neutralized in vitro but remain infectious in immune hosts. One difference between these settings is the availability of immunoglobulin Fc receptors. The question ... [more ▼]

BACKGROUND: Herpesviruses can be neutralized in vitro but remain infectious in immune hosts. One difference between these settings is the availability of immunoglobulin Fc receptors. The question therefore arises whether a herpesvirus exposed to apparently neutralizing antibody can still infect Fc receptor(+) cells. PRINCIPAL FINDINGS: Immune sera blocked murine gamma-herpesvirus-68 (MHV-68) infection of fibroblasts, but failed to block and even enhanced its infection of macrophages and dendritic cells. Viral glycoprotein-specific monoclonal antibodies also enhanced infection. MHV-68 appeared to be predominantly latent in macrophages regardless of whether Fc receptors were engaged, but the infection was not abortive and new virus production soon overwhelmed infected cultures. Lytically infected macrophages down-regulated MHC class I-restricted antigen presentation, endocytosis and their response to LPS. CONCLUSIONS: IgG Fc receptors limit the neutralization of gamma-herpesviruses such as MHV-68. [less ▲]

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See detailIgG4-related disease causing rapid evolution of a severe aortic valvular stenosis
BRULS, Samuel ULiege; Courtois, Audrey ULiege; DELVENNE, Philippe ULiege et al

in The Annals of Thoracic Surgery (2017)

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See detailIgG4-related membranous glomerulonephritis and generalized lymphadenopathy without pancreatitis: a case report
HUART, Justine ULiege; GROSCH, Stéphanie ULiege; BOVY, Christophe ULiege et al

in BMC Nephrology (2017), 18

Abstract Background: IgG4-related disease is a recently described pathologic entity. This is the case of a patient with nephrotic syndrome and lymphadenopathy due to IgG4-related disease. Such a kidney ... [more ▼]

Abstract Background: IgG4-related disease is a recently described pathologic entity. This is the case of a patient with nephrotic syndrome and lymphadenopathy due to IgG4-related disease. Such a kidney involvement is quite peculiar and has only been described a few times recently. Renal biopsy showed a glomerular involvement with membranous glomerulonephritis in association with a tubulo-interstitial nephropathy. Moreover, the patient was not suffering from pancreatitis. Case presentation: The patient is a middle-aged man of Moroccan origin. He has developed recurrent episodes of diffuse lymphadenopathies, renal failure and nephrotic syndrome. Renal biopsies showed membranous glomerulonephritis. Discussion and conclusion: The diagnostic approach of this atypical presentation is discussed in this case report as well as diagnostic criteria, therapeutic strategies, biomarkers and pathophysiology of IgG4-related disease. IgG4-related membranous glomerulonephritis is a well-established cause of membranous glomerulonephritis. It must be sought after in every patient with a previous diagnosis of IgG4-related disease and in every patient with this histological finding on renal biopsy. Corticoids are still the first-line treatment of IgG4-related disease. New therapeutic strategies are needed to avoid glucocorticoids long term side-effects. Interestingly, the patient was prescribed cyclophosphamide in addition to glucocorticoids for an immune thrombocytopenia. This treatment had a very good impact on his IgG4-related disease. [less ▲]

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See detailLa Iglesia católica y los movimienos feministas en Bélgica
Henneau, Marie-Elisabeth ULiege

in Famerée, Joseph (Ed.) Misión y lugar de las mujeres en las Iglesias (2011)

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See detailIgneous charnockites and related rocks from the Bjerkreim-Sogndal layered intrusion (Southwest Norway): a jotunite (hypersthene monzodiorite)-derived A-type granitoid suite
Duchesne, Jean-Clair ULiege; Wilmart, Edith

in Journal of Petrology (1997), 38(3), 337-369

The upper part of the Bjerkreim-Sokndal layered intrusion (BKSK) comprises a suite of charnockitic granitoids (mangerite, quartz mangerite and charnockite) with some jotunites. The petrology and ... [more ▼]

The upper part of the Bjerkreim-Sokndal layered intrusion (BKSK) comprises a suite of charnockitic granitoids (mangerite, quartz mangerite and charnockite) with some jotunites. The petrology and geochemistry (major and trace elements) of 8 main rock types (88 samples) are considered. The rocks form a suite of K2O-rich alkali-calcic granitoids of A-type, deriving from jotunitic magma. Two trends of inferred liquids are distinguished: the main liquid line of descent which passes from jotunites through 2-pyroxene quartz mangerites to amphibole charnockites, the second one which encompasses olivine-bearing quartz mangerites and charnockites and is rooted into mangeritic liquids. Comparison with the Tellnes rock series reveals that contamination by leucogranitic material has taken place simultaneously with fractional crystallization in both BKSK trends. Zr, Rb, Cs, and Th are particularly sensitive to assimilation and the higher water content in BKSK. Zircon and apatite have saturated at the liquidus of quartz mangerite around 900°C, close to the FMQ buffer. The two-pyroxene quartz mangerites cannot have been equilibrated with the mangerite cumulates on which they rest. A major influx of magma took place when mangeritic cumulates were being deposited. It mingled and partly mixed with the resident contaminated magma. [less ▲]

Detailed reference viewed: 168 (3 ULiège)