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See detailLes hyperaldostéronismes primaires
Beckers, Albert ULiege

Scientific conference (2010, December 17)

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See detailHyperammonemia after high-dose chemotherapy and stem cell transplantation.
Frere, Pascale ULiege; Canivet, Jean-Luc ULiege; Gennigens, Christine ULiege et al

in Bone Marrow Transplantation (2000), 26(3), 343-5

We report a patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft. This syndrome is not well known but is associated with a high mortality rate. Considering the ... [more ▼]

We report a patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft. This syndrome is not well known but is associated with a high mortality rate. Considering the possibility of this diagnosis in patients developing confusion and neurological degradation with respiratory alkalosis after intensive chemotherapy, could allow earlier treatment and perhaps improved survival. Possible mechanisms and potential therapies are discussed. With rapid recognition and treatment of the syndrome, the patient fully recovered. One and a half years later, she is still alive and well, on interferon for persisting myeloma. [less ▲]

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See detailHyperandrogénie: sémiologie, exploration et traitement
Beckers, Albert ULiege; Parotte, M. C.; Gaspard, Ulysse ULiege et al

in Revue Médicale de Liège (1999), 54(4), 274-282

Androgen excess (AE) is one of the most common endocrine disorders, affecting 10% of adult women before the menopause. The clinical picture varies widely depending on the etiology of AE. Most of these ... [more ▼]

Androgen excess (AE) is one of the most common endocrine disorders, affecting 10% of adult women before the menopause. The clinical picture varies widely depending on the etiology of AE. Most of these women are suffering from hirsutism, acne, menstrual disturbances, anovulation and obesity. Virilization is unusual, except in patients with ovary or adrenal cancer. Polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH) are the most frequent causes of androgen excess, accounting for more than 90% of the cases. The pathogenesis of PCOS is still an unresolved problem. A hereditary predisposition has been suggested. Enzymatic deficiency is a less frequent cause of AE, the most common deficiency being the non classic 21-OH deficiency (NCAH). AE has been implicated as a side effect of many drugs. Ovary and adrenal tumours are unusual, however, they must be considered especially in case of severe hirsutism or virilization. Complementary investigations are selected based on the result of clinical examination. Pharmacologic therapy, usually with anti-androgens, is the most widely used treatment for PCOS, IH and NCAH. Surgical therapy should be considered only when there is a particular indication such as Cushing's syndrome, ovary or adrenal tumours. [less ▲]

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See detailHyperbase fur Alpenwort
Longrée, Dominique ULiege

Scientific conference (2016)

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See detail« Hyperbase-Latin : un instrument au service des études logométriques »
Longrée, Dominique ULiege

Scientific conference (2012)

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See detailHypercalcaemia of parathyroid carcinoma controlled by immunotherapy
Mead, G. P.; Harvey, T.; Epstein, M. et al

in The Endocrine Society's 84th Annual Meeting - Abstract book (2002)

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See detailHypercalcemia treated by sunitinib
LOLY, Jean-Philippe ULiege; VALDES SOCIN, Hernan Gonzalo ULiege; Daly, Adrian ULiege et al

in 23rd meeting of the Belgian Endocrine Society - Abstract book (2013, October 19)

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See detailHypercalcemie par mutation inactivatrice du CYP24A1. Etude d'un cas et revue de la litterature.
Seidowsky, Alexandre; Villain, Cedric; Vilaine, Eve et al

in Néphrologie & Thérapeutique (2017)

We present the case of a family whose members have high levels of serum calcium (hypercalcaemia) by loss of function of the enzyme vitamin D 24-hydroxylase due to bi-allelic mutations in the CYP24A1 gene ... [more ▼]

We present the case of a family whose members have high levels of serum calcium (hypercalcaemia) by loss of function of the enzyme vitamin D 24-hydroxylase due to bi-allelic mutations in the CYP24A1 gene: c.443 T>C (p.Leu148Pro) and c.1187 G>A (p.Arg396Gln). 24-VITD hydroxylase is a key player in regulating the circulating calcitriol, its tissue concentration and its biological effects. Transmission is recessive. The estimated prevalence of stones in the affected subjects is estimated between 10 and 15%. The loss of peripheral catabolism of vitamin D metabolites in patients with an inactivating mutation of CYP24A1 is responsible for persistent high levels of 1,25-dihydroxyvitamin D especially after sun exposure and a charge of native vitamin D. Although there are currently no recommendations (French review) on this subject, this disease should be suspected in association with recurrent calcium stones with nephrocalcinosis, and a calcitriol-dependent hypercalcaemia with adapted low parathyroid hormone levels. Resistance to corticosteroid therapy distinguishes it from other calcitriol-dependent hypercalcemia. A ratio of 25-hydroxyvitamin D/24.25 hydroxyvitamin D>50, is in favor of hypercalcemia with vitamin D deficiency 24-hydroxylase. Genetic analysis of CYP24A1 should be performed at the second step. The current therapeutic management includes the restriction native vitamin D supplementation and the limitation of sun exposure. Biological monitoring will be based on serum calcium control and modulation of parathyroid hormone concentrations. [less ▲]

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See detailHypercalcémie paranéoplasique et hypercalcémie associée à la Néoplasie Multiple de type I (NEM1): traitement par Cinacalcet
VALDES SOCIN, Hernan Gonzalo ULiege; POLUS, Marc ULiege

Conference (2015, October 17)

Paraneoplastic hypercalcemia and hypercalcemia associated with neoplastic syndromes are particularly resistant to conventional hypocalcemic treatments. We present and discuss two case reports in which ... [more ▼]

Paraneoplastic hypercalcemia and hypercalcemia associated with neoplastic syndromes are particularly resistant to conventional hypocalcemic treatments. We present and discuss two case reports in which Cinacalcet was used to control hypercalcemia. Paraneoplastic hypercalcemia is present in the first case report, in association with a metastasic neuroendocrine pancreas. In the second case report ,cinacalcet is used to control hypecalcemia in a patient with multiple endocrine neoplasia and hyperparathyroidism not controlled by neck surgery. Cinacalcet is an oral agonist of the Calcium Sensing Receptor. The hypocalcemic effects of Cinacalcet have not been documented so far in hypercalcemia-paraneo plastic linked to cancer of the pancreas (Valdés-Socin & al. Rev Med Switzerland 2009). On the other hand, its use seems promising in the MEN1-associated hyperparathyroidism. (Giusti & al. Endocrine 2015). [less ▲]

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See detailHypercalcémie réfractaire et sécrétion ectopique de calcitonine dans un cancer neuroendocrine du pancréas : Effets hypocalcémiants du Cinacalcet
VALDES SOCIN, Hernan Gonzalo ULiege; LOLY, Jean-Philippe ULiege; BETEA, Daniela ULiege et al

in Annales d'Endocrinologie (2013, September), 74(4), 235-462

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic ... [more ▼]

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic neuroendocrine tumor (Ki-67= 2%) is diagnosed in a 52-year-old diabetic man. The tumor is revealed with a splenic and hepatic carcinomatosis. Plasmatic calcium was: 3.54 mmol/L (2.15 - 2.6). Biology showed hypophosphatemia, PTH < 4 ng/ml, high 1-25 OH VitD, calcitonin: 1016 ng/ml (< 12 ng/ml). He had hypercalciuria and hypophosphaturia. He received for two years several cycles of Streptozotocin-ADRIAMYCIN and FOLFOX, with partial control of the tumor mass and calcium levels. In 2012, calcitonin levels are 29 ng/ml whereas calcemia is 3.17 mmol/L. Hypercalcemia is refractory to hyperhydration, diuretics, corticosteroids, and bisphosphonates therapy. Cinacalcet (Mimpara) is prescribed up to 120 mg/day (PO). Calcemia decreases gradually from 3 to 2.87 and then 2.76 mmol/L. PTH and calcitonin-the tumor mass remain unchanged. After two months of Cinacalcet treatment, Sunitinib (Sutent) 37.5 mg per day was added. During the third month, calcium levels dropped to 2.09 mmol/L and PTH raised to 78 pg/ml, requiring discontinuation of Mimpara. Calcitonin normalized, with a further improvement over pancreatic and metastatic lesions. Conclusion: Cinacalcet is a Calcium Sensing Receptor oral agonist. Cinacalcet hypocalcemic effects have not been previously documented in pancreatic paraneoplastic hypercalcemia. In our patient, Cinacalcet has significantly improved cancer prognosis: this drug could be a new alternative in paraneoplastic hypercalcemia. [less ▲]

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See detailHypercholesterolaemia in a family of rough collie dogs.
Jeusette, Isabelle; Grauwels, Magda ULiege; Cuvelier, Christine ULiege et al

in Journal of Small Animal Practice (2004), 45(6), 319-24

A family of five privately owned rough collie dogs was referred for corneal lipidosis and also suffered from hypercholesterolaemia. The hypercholesterolaemia was characterised by an increase in the alpha ... [more ▼]

A family of five privately owned rough collie dogs was referred for corneal lipidosis and also suffered from hypercholesterolaemia. The hypercholesterolaemia was characterised by an increase in the alpha-2 high density lipoprotein-1 band and was due to an increase in the cholesterol content of the very low density lipoprotein, low density lipoprotein and possibly the high density lipoprotein-1 fractions. A low-fat and energy-restricted diet did not reduce either total cholesterol or the corneal lipidosis. Corneal lipidosis regressed with short-chain fructo-oligosaccharide supplementation. However, the effects of short-chain fructo-oligosaccharides on total cholesterol were transient and variable. [less ▲]

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See detailHypercholestérolémie modérée et coronaropathies: étude MAAS et étude 4S
Martinez, Christophe ULiege; Legrand, Victor ULiege; Kulbertus, Henri ULiege

in Revue Médicale de Liège (1995), 50(1), 35-40

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See detailHypercomplex eccentric anomaly in the unified solution to the relative orbital motion
Condurache, D.; Martinusi, Vladimir ULiege

in Advances in the Astronautical Sciences (2010), 135

The present work offers an approach to the relative orbital motion by using hypercomplex algebra. An extension to this notion is used for vectors, by introducing the hypercomplex vector in the same way as ... [more ▼]

The present work offers an approach to the relative orbital motion by using hypercomplex algebra. An extension to this notion is used for vectors, by introducing the hypercomplex vector in the same way as hypercomplex numbers are defined. The solution to the relative orbital motion is offered in all possible situations (it stands for any Keplerian reference or targeted trajectories). A unified view on the relative orbital motion is suggested, by generalizing the previous approaches. The solution is offered to the nonlinear model of the relative motion and it is expressed in a coordinate-free hypercomplex vectorial closed form. The key element of this approach is the hypercomplex eccentric anomaly, introduced via a Sundman-like vectorial regularization. [less ▲]

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See detailLes hyperconflits en organisation
Faulx, Daniel ULiege; Delvaux, Sophie

in Actes du 15ème Congrès de Psychologie du Travail et des Organisation de Langue Française. CD-rom. Québec.. (2008)

La description et la compréhension des conflits extrêmes ou « hyperconflits » constituent de nouvelles préoccupations en Psychologie du Travail et des Organisations. A partir de l’analyse des résultats de ... [more ▼]

La description et la compréhension des conflits extrêmes ou « hyperconflits » constituent de nouvelles préoccupations en Psychologie du Travail et des Organisations. A partir de l’analyse des résultats de huit focus groups composés de professionnels du traitement des conflits, nous dégageons 24 indicateurs des hyperconflits. Plus généralement, il ressort de notre étude que ces situations sont liées à une réduction de la complexité du système organisationnel couplée à une généralisation de la dynamique conflictuelle du point de vue de l’espace-temps, des processus et des conséquences. Les implications en termes d’interventions sont également discutées. [less ▲]

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See detailHyperdiploid karyotypes in acute myeloid leukemia define a novel entity : a study of 38 patients from the Groupe Francophone de Cytogenetique Hematologique (GFCH)
Luquet, I.; Laï, J. L.; Barin, C. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2008), 22(1), 132-137

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See detailHyperechogenic brain densities : relevance of perinatal etiologic factors
Dehalleux, I; Battisti, Oreste ULiege; Withofs, L. et al

Conference (1993)

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See detailHyperfine interactions and lattice dynamics of Sn21O6Cl16(OH)(14)
Sougrati, Moulay Tahar ULiege; Jouen, S.; Hannoyer, Béatrice et al

in Journal of Solid State Chemistry (2008), 181(9), 2473-2479

In this study, the tin(II) oxy-hydroxychloride Sn21O6Cl16(OH)(14) has been synthesised and investigated, This compound is the synthetic equivalent of mineral abhurite, which was discovered in 1985 as a ... [more ▼]

In this study, the tin(II) oxy-hydroxychloride Sn21O6Cl16(OH)(14) has been synthesised and investigated, This compound is the synthetic equivalent of mineral abhurite, which was discovered in 1985 as a tin corrosion product formed on the surface of tin ingots after long immersion in seawater. The Mossbauer parameters of Sn(21)O6Cl(16)(OH)(14) determined at various temperatures are reported and discussed for the first time. At room temperature, the isomer shift and the quadrupole splitting are, respectively, delta = 3.22 mm s(-1) and Delta = 1.71 mm s(-1) relative to the centroid of the spectrum of BaSnO3. ne Mossbauer recoil-free fraction has been also evaluated over a wide range of temperature. At 300 K, the recoil-free fraction of Sn21O6Cl16(OH)(14) is f(300) = 0.09 +/- 0.02. (C) 2008 Elsevier Inc. All rights reserved. [less ▲]

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