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See detailHeavy water tracing test in the underground coal gasification process at Thulin (Belgium)
Dufaux, Anne; Gaveau, Bénédicte; Létolle, René et al

in Fuel (1990), 69

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See detailHeavy-chain antibody fragments as model proteins to investigate the molecular mechanism of formation of amyloid fibrils
Chavignon, Chloé ULiege

Doctoral thesis (2015)

Amyloidoses are rather common and widespread debilitating and/or life-threatening diseases. They display structurally identical amyloid fibrils, and consequently appears to share a common, but still ... [more ▼]

Amyloidoses are rather common and widespread debilitating and/or life-threatening diseases. They display structurally identical amyloid fibrils, and consequently appears to share a common, but still poorly understood, mechanism of fibrillogenesis. Variable domains of camelid heavy-chain antibodies, referred to as VHHs or nanobodies, were chosen to investigate the factors that favour amyloid fibrillogenesis and to get a better understanding of the mechanism of Ig fibrillogenesis. Our study focused on the contribution of protein regions, i.e. the framework (FR) and the complementary determining regions (CDRs) of VHHs, to the formation of amyloid fibrils. Three VHHs were selected: cAb HuL6, cAb BcII10 and cAb BcII10 H H H, a chimera bearing the FR of cAb BcII10 and the CDRs of cAb HuL6. We first established experimental conditions suitable for fibrillogenesis: even the especially stable and soluble VHHs can form amyloid fibrils in denaturing conditions. This comforts the proposal that amyloid conformation is a generic structural form that all proteins can adopt in the appropriate conditions. Amyloid fibrils were characterised by transmission electron microscopy (TEM), circular dichroism (CD), thioflavin T (ThT) fluorescence and X-ray fibre diffraction. The kinetics of fibril formation were monitored by turbidity measurements. We then determined conditions suitable for characterising self-seeding and cross-seeding kinetics, and ascertained that the three VHHs convert into amyloid fibrils according to a nucleation-dependent process. Fibril elongation rates in self-seeding and cross-seeding experiments suggest that amyloid fibril elongation occurs through sequential addition of protein monomers to preformed fibrils. The kinetics of aggregation and self-seeding of cAb-HuL6 and cAb-BcII10 differ significantly, and a remarkable specificity for cross-seeding was observed, with cAb-BcII10 being unable to cross-seed the formation of fibrils by the two other VHHs, while cAb-HuL6 and cAb BcII10 H-H-H mutually cross-seed each other’s fibril formation. With the help of three prediction algorithms (AGGRESCAN, Zyggregator and 3D-profile), we showed that various peptides of the VHHs had the ability to form fibrils by themselves. Our results strongly suggest that the sequences of the regions forming the core of the fibrils essentially correspond to the CDRs. Concurrently, we set up experimental conditions for interrupting the fibril formation process and we characterised the multimer and fibril species formed in the early stages of fibrillogenesis by analytical ultracentrifugation (AUC) and small angle neutron scattering (SANS) ex situ. [less ▲]

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See detailHeavy-flavour pentaquarks in a chiral constituent quark model
Genovese, M.; Richard, J. M.; Stancu, Floarea ULiege et al

in Physics Letters B (1998), B425

Within the chiral constituent quark model of Glozman and Riska, we discuss the stability of heavy pentaquarks, i.e. hadrons containing four light quarks and a heavy antiquark. The spin-dependent part of ... [more ▼]

Within the chiral constituent quark model of Glozman and Riska, we discuss the stability of heavy pentaquarks, i.e. hadrons containing four light quarks and a heavy antiquark. The spin-dependent part of the Hamiltonian is dominated by the short-range part of the Goldstone-boson-exchange interaction. We find that these systems are not bound, having an energy above the lowest dissociation threshold into a baryon and a meson. [less ▲]

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See detailHeavy-quarkonium interaction in QCD at finite temperature
Arleo, François; Cugnon, Joseph ULiege; Kalinovsky, Youri

in Physics Letters B (2005), 614(1-2), 44-52

We explore the temperature dependence of the heavy-quarkonium interaction based on the Bhanot-Peskin leading order perturbative QCD analysis. The Wilson coefficients are computed solving the Schrodinger ... [more ▼]

We explore the temperature dependence of the heavy-quarkonium interaction based on the Bhanot-Peskin leading order perturbative QCD analysis. The Wilson coefficients are computed solving the Schrodinger equation in a screened Coulomb heavy-quark potential. The inverse Mellin transform of the Wilson coefficients then allows for the computation of the 1S and 2S heavy-quarkonium gluon and pion total cross section at finite screening/temperature. As a phenomenological illustration, the temperature dependence of the 1S charmonium thermal width is determined and compared to recent lattice QCD results. © 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailHeavy/light chain (HLC) and free light chain (FLC) analysis allow sensitive monitoring of multiple myeloma patients and AID detection of clonal changes
Dierge, Laurine; LUTTERI, Laurence ULiege; Chauvet, D et al

in Biochimica Clinica (2013, May), 37(SS), 618

Detailed reference viewed: 69 (8 ULiège)
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See detailHéboïdophrenia: The hazardous interplay of psychosis and psychopathy
De Page, Louis; Englebert, Jérôme ULiege

Poster (2016, May 24)

Introduction The diagnostic entity of heboidophrenia has been consigned to oblivion despite its clinical, prognostic, criminogenic value. At the core of this diagnosis lies specifics interactions between ... [more ▼]

Introduction The diagnostic entity of heboidophrenia has been consigned to oblivion despite its clinical, prognostic, criminogenic value. At the core of this diagnosis lies specifics interactions between psychosis and psychopathy. The diagnosis was first coined by Kalhbaum in 1890, was revived by Anglo-Saxon literature in the first half of the 20th century, and by French psychiatrists in the late 90’. Method We integrated literary sources, clinical experience and an own pilot study as a stepping-stone for a more in-depth research. Cases (n=20) were selected out of samples of Mentally Disordered Offenders in Belgian Medium and High Risk Forensic Facilities. Files, records and therapist’s experiences were quantitatively analysed iteratively to cull subtypes from each other. We here present preliminary qualitative results, more indepth qualitative and quantitative results will be produced. Results The diagnosis subsumes more than a mere DSM-IV-TR Axis I & II comorbidity, it can be seen from a developmental perspective, or from a structural perspective. Both vantage points suggest an interplay between the (paranoid) psychotic process and the antisocial behaviour, where both trigger and induce each other. At this point, we found evidence for three subtypes modes of interplay; 1) mood instability patterns induced either psychopathic or psychotic phenotypic presentation, 2) according to personality organization and its defensive functioning (were psychopathy defends against psychosis), and 3) phenotypic expression of both components (psychopathy and psychosis) linearly co-dependent. Discussion Despite its incremental value, little is known about the therapeutic prospects of this diagnosis. Current results indicate that these patients do question competency to answer for their deeds in a peculiar manner, relapse more often, reoffend more often, do evade treatment opportunities (if they have any), act out more often (in both antisocial and psychotic ways), induce a particular negative counter-transference in psychiatric teams, etc. Because of these particularities and their versatile phenotype presentation, heboidophrenia patients cannot simply be assimilated to the “high risk & high care” population, but need special supervision and clinical insight. In this research, we aim(ed) at discerning semiologic signs in order to support the diagnostic process. [less ▲]

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See detailHedendaagse Nigeriaanse Literatuur
Tunca, Daria ULiege

Conference given outside the academic context (2009)

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See detailHedge Fund Market Risk Exposures: A Survey
Lambert, Marie ULiege

in Finance (2012), 33(1), 39-78

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See detailHedge fund performance and persistence in bull and bear markets
Capocci, Daniel; Corhay, Albert ULiege; Hübner, Georges ULiege

in European Journal of Finance (2005), 11(5), 361-392

This paper tests the performance of 2894 hedge funds in a time period that encompasses unambiguously bullish and bearish trends whose pivot is commonly set at March 2000. The database proves to be fairly ... [more ▼]

This paper tests the performance of 2894 hedge funds in a time period that encompasses unambiguously bullish and bearish trends whose pivot is commonly set at March 2000. The database proves to be fairly trustable with respect to the most important biases in hedge funds studies, despite the high attrition rate of funds observed in the down market. An original ten-factor composite performance model is applied that achieves very high significance levels. The analysis of performance indicates that most hedge funds significantly outperformed the market during the whole test period, mostly thanks to the bullish subperiod. In contrast, no significant underperformance of individual hedge funds strategies is observed when markets headed south. The analysis of persistence yields very similar results, with most of the predictability being found among middle performers during the bullish period. However, the "Market Neutral" strategy represents a remarkable exception, as abnormal performance is sustained throughout and significant persistence can be found between the 20% and 69% best performers in this category, probably thanks to an extreme adaptability and a very active investment behaviour.(Abstract EconLit copié le 29/06/06) [less ▲]

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See detailHedge fund return specification with errors-in-variables
Coën, Alain; Hübner, Georges ULiege; Desfleurs, Aurélie

in Journal of Derivatives and Hedge Funds (2010), 16(1), 22-52

In linear models for hedge fund returns, errors-in-variables may significantly alter the measurement of factor loadings and the estimation of abnormal performance. The higher moment estimator (HME ... [more ▼]

In linear models for hedge fund returns, errors-in-variables may significantly alter the measurement of factor loadings and the estimation of abnormal performance. The higher moment estimator (HME) introduced by Dagenais and Dagenais (1997) effectively deals with these issues. Results on individual funds show that the HME specification does not uncover systematic performance biases, but can modify estimated alphas in most cases and identifies relative persistence for directional funds in bearish market conditions. Overall, the risk premia calculated with HME remain relatively stable when compared to ordinary least squares specifications. [less ▲]

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See detailHedge fund styles and macroeconomic uncertainty
Platania, Federico ULiege; Lambert, Marie ULiege

Conference (2016, May 25)

This paper examines the dynamic trading strategies implemented by hedge fund managers using a Kalman filter of hedge fund betas across styles. We further investigate the risk drivers of dynamic trades ... [more ▼]

This paper examines the dynamic trading strategies implemented by hedge fund managers using a Kalman filter of hedge fund betas across styles. We further investigate the risk drivers of dynamic trades, examining which conditioning/macroeconomic variables strongly lead the time variation in fund trades. We report the significance of macroeconomic factors such as interest rates, dividend yield, GDP growth and US unemployment. We show that hedge fund managers do control the intensity of their exposures according to economic uncertainty and that differences between up- and down-market regimes can be observed. Commonly, Hedge funds tend to dislike high-dividend paying stocks. Besides, all hedge fund styles are shown to display pro-cyclical exposures towards directional equity factors as well as credit and liquidity risks. Small growth stocks, however, are revealed to be crisis investments whose allocation increases with unemployment, inflation or volatility. As volatility increases, the value of growth options embedded into growth stocks indeed increases. Growth stocks are shown to hedge market reversals and volatility. The outperformance of growth companies in recessions might also relate to their cost flexibility. Allocation to small stocks embed strong micro risks and might also constitute a hedge in economic slowdowns. This might explain why some funds with such a particular investment focus appear to be countercyclical. [less ▲]

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See detailHedge fund styles and macroeconomic uncertainty
Platania, Federico ULiege; Lambert, Marie ULiege

Conference (2016, May 10)

This paper examines the dynamic trading strategies implemented by hedge fund managers using a Kalman filter of hedge fund betas across styles. We further investigate the risk drivers of dynamic trades ... [more ▼]

This paper examines the dynamic trading strategies implemented by hedge fund managers using a Kalman filter of hedge fund betas across styles. We further investigate the risk drivers of dynamic trades, examining which conditioning/macroeconomic variables strongly lead the time variation in fund trades. We report the significance of macroeconomic factors such as interest rates, dividend yield, GDP growth and US unemployment. We show that hedge fund managers do control the intensity of their exposures according to economic uncertainty and that differences between up- and down-market regimes can be observed. Commonly, Hedge funds tend to dislike high-dividend paying stocks. Besides, all hedge fund styles are shown to display pro-cyclical exposures towards directional equity factors as well as credit and liquidity risks. Small growth stocks, however, are revealed to be crisis investments whose allocation increases with unemployment, inflation or volatility. As volatility increases, the value of growth options embedded into growth stocks indeed increases. Growth stocks are shown to hedge market reversals and volatility. The outperformance of growth companies in recessions might also relate to their cost flexibility. Allocation to small stocks embed strong micro risks and might also constitute a hedge in economic slowdowns. This might explain why some funds with such a particular investment focus appear to be countercyclical. [less ▲]

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See detailHedge fund styles and macroeconomic uncertainty
Platania, Federico ULiege; Lambert, Marie ULiege

E-print/Working paper (2016)

This paper examines the dynamic trading strategies implemented by hedge fund managers using a Kalman filter of hedge fund betas across styles. We further investigate the risk drivers of dynamic trades ... [more ▼]

This paper examines the dynamic trading strategies implemented by hedge fund managers using a Kalman filter of hedge fund betas across styles. We further investigate the risk drivers of dynamic trades, examining which conditioning/macroeconomic variables strongly lead the time variation in fund trades. We report the significance of macroeconomic factors such as interest rates, dividend yield, GDP growth and US unemployment. We show that hedge fund managers do control the intensity of their exposures according to economic uncertainty and that differences between up- and down-market regimes can be observed. Commonly, Hedge funds tend to dislike high-dividend paying stocks. Besides, all hedge fund styles are shown to display pro-cyclical exposures towards directional equity factors as well as credit and liquidity risks. Small growth stocks, however, are revealed to be crisis investments whose allocation increases with unemployment, inflation or volatility. As volatility increases, the value of growth options embedded into growth stocks indeed increases. Growth stocks are shown to hedge market reversals and volatility. The outperformance of growth companies in recessions might also relate to their cost flexibility. Allocation to small stocks embed strong micro risks and might also constitute a hedge in economic slowdowns. This might explain why some funds with such a particular investment focus appear to be countercyclical. [less ▲]

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See detailHedge fund styles and market uncertainty
Platania, Federico ULiege; Lambert, Marie ULiege

Conference (2016, June 03)

This paper examines the dynamic trading strategies implemented by hedge fund managers using a Kalman filter of hedge fund betas across styles. We further investigate the risk drivers of dynamic trades ... [more ▼]

This paper examines the dynamic trading strategies implemented by hedge fund managers using a Kalman filter of hedge fund betas across styles. We further investigate the risk drivers of dynamic trades, examining which conditioning/macroeconomic variables strongly lead the time variation in fund trades. We report the significance of macroeconomic factors such as interest rates, dividend yield, GDP growth and US unemployment. We show that hedge fund managers do control the intensity of their exposures according to economic uncertainty and that differences between up- and down-market regimes can be observed. Commonly, Hedge funds tend to dislike high-dividend paying stocks. Besides, all hedge fund styles are shown to display pro-cyclical exposures towards directional equity factors as well as credit and liquidity risks. Small growth stocks, however, are revealed to be crisis investments whose allocation increases with unemployment, inflation or volatility. As volatility increases, the value of growth options embedded into growth stocks indeed increases. Growth stocks are shown to hedge market reversals and volatility. The outperformance of growth companies in recessions might also relate to their cost flexibility. Allocation to small stocks embed strong micro risks and might also constitute a hedge in economic slowdowns. This might explain why some funds with such a particular investment focus appear to be countercyclical. [less ▲]

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See detailHedge fund trading strategies and performance: theory and practice
Lambert, Marie ULiege

Scientific conference (2017, April 28)

Detailed reference viewed: 66 (5 ULiège)
See detailHedge Funds: Insights in Performance Measurement, Risk Analysis, and Portfolio Allocation
Gregoriou, Greg; Hübner, Georges ULiege; Papageorgiou, Nicolas et al

Book published by J. Wiley & sons (2005)

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See detailHedgehog ringworm in humans and a dog.
Pierard-Franchimont, Claudine; Hermanns, Jean-François ULiege; Collette, C. et al

in Acta Clinica Belgica (2008), 64

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See detailHedgehog signaling pathway is inactive in colorectal cancer cell lines
Chatel, Guillaume; Ganeff, Corinne ULiege; Boussif, Naima et al

in International Journal of Cancer = Journal International du Cancer (2007), 121(12), 2622-2627

The Hedgehog (Hh) signaling pathway plays an important role in human development. Abnormal activation of this pathway has been observed in several types of human cancers, such as the upper gastro ... [more ▼]

The Hedgehog (Hh) signaling pathway plays an important role in human development. Abnormal activation of this pathway has been observed in several types of human cancers, such as the upper gastro-intestinal tract cancers. However, activation of the Hh pathway in colorectal cancers is controversial. We analyzed the expression of the main key members of the Hh pathway in 7 colon cancer cell lines in order to discover whether the pathway is constitutively active in these cells. We estimated the expression of SHH, IHH, PTCH, SMO, GLI1, GLI2, GLI3, SUFU and HHIP genes by RT-PCR. Moreover, Hh ligand, Gli3 and Sufu protein levels were quantified by western blotting. None of the cell lines expressed the complete set of Hh pathway members. The ligands were absent from Colo320 and HCT116 cells, Smo from Colo205, HT29 and WiDr. GLI1 gene was not expressed in SW480 cells nor were GLI2/GLI3 in Colo205 or Caco-2 cells. Furthermore the repressive form of Gli3, characteristic of an inactive pathway, was detected in SW480 and Colo320 cells. Finally treatment of colon cancer cells with cyclopamine, a specific inhibitor of the Hh pathway, did not downregulate PTCH and GLI1 genes expression in the colorectal cells, whereas it did so in PANC1 control cells. Taken together, these results indicate that the aberrant activation of the Hh signaling pathway is not common in colorectal cancer cell lines. (c) 2007 Wiley-Liss, Inc. [less ▲]

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See detailHedgehog- and mTOR-targeted therapies for advanced basal cell carcinomas.
FRANCHIMONT, Claudine ULiege; Hermanns-Lê, Trinh ULiege; PAQUET, Philippe ULiege et al

in Future Oncology (2015), 11

Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs have a mutation in patched homologue 1 (PTCH 1) or smoothened (SMO), two conducting proteins of the Hedgehog (Hh ... [more ▼]

Basal cell carcinomas (BCCs) are the most frequent human cancer. Over 90% of all BCCs have a mutation in patched homologue 1 (PTCH 1) or smoothened (SMO), two conducting proteins of the Hedgehog (Hh) pathway. They rarely progress deeply and metastasize; however, if they do, these advanced BCC become amenable to treatment by inhibiting the Hedgehog and the P13K–mTOR pathways. Such innovative drugs include vismodegib, cyclopamine, itraconazole, everolimus and a few other agents that are in early clinical development. [less ▲]

Detailed reference viewed: 97 (26 ULiège)