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See detailEffect of siRNAs targeting the EGFR T790M mutation in a non-small cell lung cancer cell line resistant to EGFR tyrosine kinase inhibitors and combination with various agents.
Chen, Gang; Kronenberger, Peter; Teugels, Erik et al

in Biochemical and Biophysical Research Communications (2013), 431(3), 623-9

The epidermal growth factor receptor (EGFR) is a validated therapeutic target in non-small cell lung cancer (NSCLC). However, some mutations confer resistance to current available agents, especially the ... [more ▼]

The epidermal growth factor receptor (EGFR) is a validated therapeutic target in non-small cell lung cancer (NSCLC). However, some mutations confer resistance to current available agents, especially the frequently occurring T790M mutation. In the current study, we have examined, in a NSCLC cell line H1975 containing both L858R and T790M mutations, the effect of T790M-specific-siRNAs versus other EGFR-specific-siRNAs. T790M-specific-siRNAs were able to inhibit T790M and EGFR mRNA, to reduce EGFR protein expression, as well as to reduce the cell growth and induce cell caspase activity in H1975 cells. However, this effect showed less potency compared to the other EGFR-specific-siRNAs. EGFR-specific-siRNAs strongly inhibited cell growth and induced apoptosis in H358, H1650, H292, HCC827 and also in H1975 cells, which showed weak response to tyrosine kinase inhibitors (TKIs) or cetuximab. The addition of T790M-specific-siRNAs could rescue the sensitivity of T790M mutant H1975 cells to TKIs. The combination of T790M-specific-siRNAs and cetuximab also additively enhanced cell growth inhibition and induction of apoptosis in H1975 cells. Among the anti-EGFR agents tested, the strongest biological effect was observed when afatinib was combined with T790M-specific-siRNAs. Afatinib also offered extra effect when combined with cetuximab in H1975 cells. In conclusion, knock-down of T790M transcript by siRNAs further decreases the cell growth of T790M mutant lung cancer cells that are treated with TKIs or cetuximab. The combination of a potent, irreversible kinase inhibitor such as afatinib, with T790M-specific-siRNAs should be further investigated as a new strategy in the treatment of lung cancer containing the resistant T790M mutation. [less ▲]

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See detailEffect Of Site Location And Collecting Period On The Chemical Composition Of Hyptis Spicigera Lam. An Insecticidal Essential Oil From North-Cameroon
Noudjou, Félicité; Kouninki, Habiba; Ngamo, Léonard S.T. et al

in Journal of Essential Oil Research (2007), 19(6), 597-601

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See detailThe effect of sitting position on consciousness levels and pupillary light reflex
Niimi, Masachika ULiege

in Journal of the Intensive Care Society (2020)

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See detailThe effect of size, weight, body compartment, sex and reproductive status on the bioaccumulation of 19 trace elements in rope-grown Mytilus galloprovincialis
Richir, Jonathan ULiege; Gobert, Sylvie ULiege

in Ecological Indicators (2014), 36

Numerous trace elements (TEs) can be considered as potential pollutants of the environment, their mining productions and industrial uses increasing worldwide. Their monitoring can be achieved through the ... [more ▼]

Numerous trace elements (TEs) can be considered as potential pollutants of the environment, their mining productions and industrial uses increasing worldwide. Their monitoring can be achieved through the use of bioindicator species, such as the Mediterranean mussel Mytilus galloprovincialis (Lamarck, 1819). That species has been widely used to monitor the chemical pollution of coastal ecosystems by Cr, Ni, Cu, Zn, Cd, Pb, As, Ag and V. Conversely, environmental levels of Be, Al, Fe, Mn, Co, Se, Mo, Sn, Sb and Bi have been little or not monitored so far in mussel watch programs. Bioaccumulation processes of these 19 TEs in rope-grown M. galloprovincialis purchased from a salt pond with good chemical water quality were thus investigated in the present study. Mussels efficiently accumulated the 19 studied TEs. Bioaccumulation processes were driven by numerous mutually dependent biological parameters such as the mussel size and flesh weight, the sex and the reproductive status and the body compartment considered. TE bioaccumulation was a power function of the mussel soft body dry weight; total contents linearly increased with the shell length. Small-size mussels overall concentrated more TEs, with a high inter-individual variability, consequently influencing the modelling of their bioaccumulation in the whole rope population. Although a large range of rope-grown M. galloprovincialis sizes can be used for monitoring purposes, one will thus take care not to use extreme size individuals. The influence of gametogenesis in determining female body higher TE concentrations prior to spawning could not be neglected and varied depending on the element. TEs were preferentially accumulated in the hepatopancreas, except for Zn, Se, Cd and Mo, more concentrated in gills. Gametogenesis did not influence TE distribution between body compartments, but likely diluted their concentrations as a direct consequence of massive reproductive tissue production. So, results from the present study underline the potential use of M. galloprovincialis in the biomonitoring of numerous little studied TEs and give some insights into the decisive role played by some relevant biological parameters in bioaccumulation processes of the 19 investigated TEs in rope-grown mussels. [less ▲]

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See detailEffect of SK channel blockade on the firing of dorsal raphe neurons in anaesthetized rats
Alleva, Livia ULiege; Rouchet, Nathalie; Waroux, Olivier ULiege et al

Poster (2006, October 17)

K channels are small conductance calcium-activated potassium channels which trigger an outward current generating an afterhyperpolarization (AHP). This AHP follows a single or a train of action potential ... [more ▼]

K channels are small conductance calcium-activated potassium channels which trigger an outward current generating an afterhyperpolarization (AHP). This AHP follows a single or a train of action potential, and therefore is important in the regulation of the firing frequency and/or pattern of many types of neurons. Serotonergic (5-HT) neurons from the raphe nuclei express SK channels and exhibit a significant AHP which can be efficiently blocked in vitro by apamin and N-methyl laudanosine (NML) (Scuvée-Moreau et al, 2004). In the later study, we found that some but not all neurons (50%) had a significantly increase in their firing rate when positive current was injected after SK channel blockade. In order to determine the physiological relevance of these channels in vivo, single unit extracellular recordings were carried out in anesthetized rats and combined with iontophoresis of the specific non-peptidic SK channel blocker, UCL1684. 5-HT neurons were tested for their inhibitory response to locally applied 5-HT and histological analysis confirmed the localization of the recording site. UCL 1684 was used at a concentration of 200 µM. Out of 11 neurons recorded, 6 showed a significant increase in the production of doublets, with no effect on their mean firing rate as compared to the control condition. The other neurons were completely unaffected. These results suggest that the responsiveness of presumed 5-HT neurons to SK channel block is variable. Although the use of 200 µM UCL allow us to be sure of a sufficient SK blockade at the recording site (Waroux et al, 2005), we can not rule out the possibility that SK channels present at the dendritic level were not completely blocked. In conclusion, SK channels in vivo might play a role in controlling the firing pattern of a subgroup of 5-HT neurons. [less ▲]

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See detailEffect of small strain rate variations on the identification of the compressive behaviour of Ti6Al4V
Tuninetti, Victor; Flores, Paulo; Medina, C et al

in Proceedings of Giens 2019 (2019, May 13)

Ti6Al4V is an hcp material that exhibits a strain rate sensitive behaviour and the tension compression asymmetry yielding known as the Strength Differential (SD). To quantify the SD effect of this alloys ... [more ▼]

Ti6Al4V is an hcp material that exhibits a strain rate sensitive behaviour and the tension compression asymmetry yielding known as the Strength Differential (SD). To quantify the SD effect of this alloys, initial yield compressive stress at different temperatures are computed by performing two type of tests, the conventional constant die speed and the constant strain rate compression tests. The results [less ▲]

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See detailThe Effect of Smoking on the Fundamental Frequency of the Speaking Voice
Ayoub, Marie-Reine; Larrouy-Maestri, Pauline; Morsomme, Dominique ULiege

in Journal of Voice (2019)

Summary: Objective. Little is known about the impact of smoking on voice acoustics. Some studies have found that tobacco affects the fundamental frequency of the voice, whereas others have not. This study ... [more ▼]

Summary: Objective. Little is known about the impact of smoking on voice acoustics. Some studies have found that tobacco affects the fundamental frequency of the voice, whereas others have not. This study aimed to overcome the major methodological limitations observed in previous studies by strictly controlling several variables that could clarify the effect of smoking on the speaking voice. Methods. Lebanese men were chosen for this study. Thirty nonsmokers, 30 cigarette smokers, and 30 water-pipe smokers were matched on the basis of age, height, and weight. The 90 participants were asked to complete the Voice Handicap Index, sustain the vowel /a/, read 10 sentences in French and Arabic, and speak spontaneously in both lan- guages. The mean fundamental frequency (F0), speaking fundamental frequency (SFF), jitter, and standard deviation of F0 were measured using Praat and Vocalab4 and were compared between the groups. Results. The Voice Handicap Index scores differed significantly between nonsmokers and cigarette smokers and between nonsmokers and water-pipe smokers. Results also show that cigarette smokers’ F0 and SFF were significantly lower than nonsmokers’ results. No significant differences were found between water-pipe smokers and nonsmokers. The jitter and the standard deviation of F0 did not differ significantly between the two groups. Conclusions. Our findings clearly demonstrate the effect of smoking on the voice: smokers reported more voice com- plaints, and cigarette smokers presented lower F0 and SFF in French and in Arabic when age, height, and weight were controlled. Further investigations using similar strict controls over individual variables and additional measures are encouraged to better understand the effect of water-pipe smoking on the voice. [less ▲]

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See detailThe effect of social security on saving: the case of Belgium with a particular emphasis on the behaviour of the aged
Pestieau, Pierre ULiege; Perelman, Sergio ULiege

in Empirical Economics (1984), (9), 15-26

Based on a consumer expenditure function estimated with Belgian time series data, this paper analyses the impact of social security on personal saving. It shows that social security has a depressive ... [more ▼]

Based on a consumer expenditure function estimated with Belgian time series data, this paper analyses the impact of social security on personal saving. It shows that social security has a depressive effect, mainly by affecting the saving behavior of the aged. [less ▲]

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See detailThe Effect of Sodium Monofluorophosphate Plus Calcium on Vertebral Fracture Rate in Postmenopausal Women with Moderate Osteoporosis. A Randomized, Controlled Trial
Reginster, Jean-Yves ULiege; Meurmans, L.; Zegels, Brigitte ULiege et al

in Annals of Internal Medicine (1998), 129(1), 1-8

BACKGROUND: Fluoride is effective in increasing trabecular bone mineral density (BMD) in the spine, but its efficacy in reducing vertebral fracture rates and its effect on BMD at cortical sites are ... [more ▼]

BACKGROUND: Fluoride is effective in increasing trabecular bone mineral density (BMD) in the spine, but its efficacy in reducing vertebral fracture rates and its effect on BMD at cortical sites are controversial. OBJECTIVE: To study the effect of low-dose fluoride (sodium monofluorophosphate [MFP]) plus a calcium supplement over 4 years on vertebral fractures and BMD at the lumbar spine and total hip in postmenopausal women with moderately low BMD of the spine. DESIGN: Randomized, double-blind, controlled clinical trial. SETTING: Outpatient clinic for osteoporosis at a university medical center. PATIENTS: 200 postmenopausal women with osteoporosis (according to the World Health Organization definition) and a T-score less than -2.5 for BMD of the spine. INTERVENTION: Women were randomly assigned (100 patients per group) to continuous daily treatment for 4 years with 1) oral MFP (20 mg of equivalent fluoride) plus 1000 mg of calcium (as calcium carbonate) or 2) calcium only. MEASUREMENTS: Lateral spine radiographs were taken at enrollment and at each year of follow-up for detection of new vertebral fractures (defined as a reduction > or =20% and > or =4 mm from baseline in any of the heights of a vertebral body). Nonvertebral fractures were also recorded. All analyses were done with the intention-to-treat approach. RESULTS: Radiologic follow-up was possible for 164 of 200 patients (82%). The rate of new vertebral fractures during the 4 years of the study was lower in the MFP-plus-calcium group (2 of 84 patients; 2.4% [95% CI, 0.3% to 8.3%]) than in the calcium-only group (8 of 80 patients; 10% [CI, 4.4% to 18.8%]). The difference between the groups was 7.6 percentage points (CI, 0.3 to 15 percentage points) (P = 0.05). A moderate but progressive increase in BMD of the spine (10.0% +/- 1.5% at 4 years) was found for MFP plus calcium compared with calcium only (P < 0.001), whereas the more modest increase in BMD of the total hip seen with MFP plus calcium (1.8% +/- 0.6%) did not differ from the increase seen with calcium only. CONCLUSIONS: Low-dose fluoride (20 mg/d) given continuously with calcium for prolonged periods can decrease vertebral fracture rates compared with calcium alone in patients with mild to moderate osteoporosis. [less ▲]

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See detailEffect of sodium nitroprusside on complement activation induced by cardiopulmonary bypass: A clinical and experimental study
Seghaye, Marie-Christine ULiege; Duchateau, J.; Grabitz, R. G. et al

in Journal of Thoracic and Cardiovascular Surgery (1996), 111(4), 882-892

Complement activation and leukocyte stimulation were prospectively studied during and after cardiopulmonary bypass in 16 children receiving sodium nitroprusside-a nitrovasodilator releasing nitric oxide ... [more ▼]

Complement activation and leukocyte stimulation were prospectively studied during and after cardiopulmonary bypass in 16 children receiving sodium nitroprusside-a nitrovasodilator releasing nitric oxide-for vasodilation during the cooling and rewarming periods of extracorporeal circulation. Results were compared with those in 29 patients who were not treated with sodium nitroprusside during the operation. Patients treated with sodium nitroprusside had significantly less C3 conversion during cardiopulmonary bypass as measured by the ratio C3d/C3 (p < 0.05) and significantly less C5a liberation immediately after cardiopulmonary bypass (p < 0.005) than patients not treated with sodium nitroprusside. C4 was not overtly consumed in our series. Leukocyte count during the rewarming period of cardiopulmonary bypass, but not leukocyte elastase release during cardiopulmonary bypass, was significantly reduced in patients treated with sodium nitroprusside (p < 0.05). In vitro experiments were conducted to analyze the effect of sodium nitroprusside on complement hemolytic activity initiated by the classic and the alternate pathways and on zymosan-induced C3 conversion by the activation of the alternate pathway. The in vitro experiments clearly demonstrate inhibition of complement hemolytic activity by sodium nitroprusside in the sera tested. The 50% inhibitory concentration of sodium nitroprusside on the available complement hemolytic activity was less through the alternate pathway than through the classic one (4.2 ± 0.8 mmol/L and 14.0 ± 2.88 mmol/L, respectively). The decrease of complement hemolytic activity measured was dose-dependent and was enhanced by the sodium nitroprusside preincubation of the sera tested. This effect was related to the duration of preincubation. Sodium nitroprusside photodegradation (enhancing nitric oxide release) increased the anticomplementary effect of the drug, reducing the 50% inhibitory concentration on complement hemolytic activity to 0.24 to 0.02 mmol/L for the alternate pathway and 2.74 o 0.3 mmol/L for the classic pathway. The zymosan-induced C3 conversion was inhibited by sodium nitroprusside. Nitroglycerin and isosorbide dinitrate (other nitric oxide donors) had in vitro effects on complement hemolytic activity similar to those of nonphotodegraded sodium nitroprusside at similar concentrations (1 mmol/L). Our results suggest that sodium nitroprusside, both in vitro and in vivo, has an inhibiting effect on complement activation initiated by both classic and alternate pathways and that this effect is mediated by nitric oxide release from sodium nitroprusside. This is the first report on the anticomplementary effect of sodium nitroprusside by nitric oxide release. [less ▲]

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See detailEffect of soft sulfidization Ore : Kansanshi (Zambia) : HG5
Bastin, David ULiege; Kottgen, Axel

Report (2009)

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See detailEffect of Soil Geomechanical Properties and Geo-Environmental Factors on Landslide Predisposition at Mount Oku, Cameroon
Love Djukem, Wamba Danny; Braun, Anika; Ludovic Wouatong, Armand Sylvain et al

in International Journal of Environmental Research and Public Health (2020), 17(18), 1-27

In this work, we explored a novel approach to integrate both geo-environmental and soil geomechanical parameters in a landslide susceptibility model. A total of 179 shallow to deep landslides were ... [more ▼]

In this work, we explored a novel approach to integrate both geo-environmental and soil geomechanical parameters in a landslide susceptibility model. A total of 179 shallow to deep landslides were identified using Google Earth images and field observations. Moreover, soil geomechanical properties of 11 representative soil samples were analyzed. The relationship between soil properties was evaluated using the Pearson correlation coe cient and geotechnical diagrams. Membership values were assigned to each soil property class, using the fuzzy membership method. The information value method allowed computing the weight value of geo-environmental factor classes. From the soil geomechanical membership values and the geo-environmental factor weights, three landslide predisposition models were produced, two separate models and one combined model. The results of the soil testing allowed classifying the soils in the study area as highly plastic clays, with high water content, swelling, and shrinkage potential. Some geo-environmental factor classes revealed their landslide prediction ability by displaying high weight values. While the model with only soil properties tended to underrate unstable and stable areas, the model combining soil properties and geo-environmental factors allowed a more precise identification of stability conditions. The geo-environmental factors model and the model combining geo-environmental factors and soil properties displayed predictive powers of 80 and 93%, respectively. It can be concluded that the spatial analysis of soil geomechanical properties can play a major role in the detection of landslide prone areas, which is of great interest for site selection and planning with respect to sustainable development at Mount Oku. [less ▲]

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See detailEffect of solution treatment on the fracture mechanisms of AlSi10Mg parts produced by Selective Laser Melting
Delahaye, Jocelyn ULiege; Mertens, Anne ULiege; Dedry, Olivier ULiege et al

Poster (2017, September 21)

Al alloy AlSi10Mg processed by Selective Laser Melting (SLM) displays high hardness and tensile strength due to its very fine eutectic microstructure [1]. However, as-built material exhibits low ductility ... [more ▼]

Al alloy AlSi10Mg processed by Selective Laser Melting (SLM) displays high hardness and tensile strength due to its very fine eutectic microstructure [1]. However, as-built material exhibits low ductility which is detrimental for applications where a high resilience is needed. To overcome this issue, solution heat treatment can be applied to soften and ductilize the material [2]. The very fine eutectic microstructure then turns into a dispersion of coarse globular Si precipitates. The distribution of Si precipitates seems to play a role in the fracture mechanism in as-built as well as solutionized tempers, but this effect is not yet fully understood [1,3]. Moreover, the lack of quantitative data makes it difficult to link precisely the fracture mechanisms to specific microstructural features. This study aims at investigating the role of the Si phase in the rupture mechanism, for both as-built and solutionized samples. It will focus more particularly on the heterogeneity of the distribution of Si precipitates where cracks are more likely to occur. Al cells size, along with the volume fraction and distribution of Si precipitates have been quantified by SEM image analysis. Al lattice parameter and Si crystallite size have been determined by X-ray diffraction/Rietveld analysis. For the image analysis, two types of specific zones have been observed i.e. the core and boundary of melt pools and Al grains, at different locations for representativity. These quantitative data have been compared with typical features observed on the fractured surface of tensile specimen. 1. D.-K. Kim et al. J. Alloys Compd. 686 (2016) 281. 2. W. Li et al., Mat. Sci. & Eng. A. 663 (2016) 116, 3. N.T. Aboulkhair et al. Mat. Sci. & Eng. A. 667 (2016) 139. [less ▲]

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See detailEffect of solvent concentration on the energy demand of an absorption-based natural gas sweetening plant
Berchiche, Mohamed El Amine ULiege; Garcia, Monica; Belaadi, Salah et al

Poster (2018, October 23)

Amine-based chemical absorption is the most advanced CO2 capture system. Yet, high energy requirement is a major hinder to its wide deployment. Among the possible routes of improvement is the use of novel ... [more ▼]

Amine-based chemical absorption is the most advanced CO2 capture system. Yet, high energy requirement is a major hinder to its wide deployment. Among the possible routes of improvement is the use of novel amines that can achieve the trade-off between robustness and low regeneration energy. Our work investigates the use of MDEA/DEA as solvent for the capture of CO2 from natural gas. The presence of BTEX (Benzene, Toluene, Ethyl Benzene and Xylene) in the raw natural gas was taken into account. AspenHysys v9 was used to simulate the chemical absorption system. The impact of solvent composition on key process variables, the required flow rate to achieve transport specification, required reboiler duty, pumping energy, BTEX incineration energy and amine losses, were studied. The optimal operating point corresponding to the lowest energy requirement was identified and the separate contribution of each process parameter was estimated. [less ▲]

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See detailEffect of somatic growth on pulmonary function values in healthy Friesian cattle
Lekeux, Pierre ULiege; Hajer, R.; Breukink, H. J.

in American Journal of Veterinary Research (1984), 45(10), 2003-2007

Growth-related changes in pulmonary function values (PFV) of cattle were investigated by a cross-sectional study of 40 healthy Dutch Friesian cattle, 3 days to 13 years of age and weighing 37 to 660 kg ... [more ▼]

Growth-related changes in pulmonary function values (PFV) of cattle were investigated by a cross-sectional study of 40 healthy Dutch Friesian cattle, 3 days to 13 years of age and weighing 37 to 660 kg. Technical and methodologic procedures and body conformation and condition were standardized. A regression analysis was done with 4 independent variables (body weight, thoracic perimeter, body surface area, and age) and with PFV measured in this study. Ventilation values, dynamic lung compliance, and viscous work of breathing changed linearly with somatic growth. Respiratory frequency, total pulmonary resistance, and arterial oxygen tension showed an exponential relationship with all the independent variables. On the other hand, intrapleural pressure values were weakly correlated with body size indexes. The most important growth-related changes in PFV occurred at approximately 1 year of age. A significant (P less than or equal to 0.05) difference between immature and mature cattle was shown for the blood-gas values and the specific values of the breathing mechanics. The dynamic lung compliance/lung weight was lower and the total pulmonary resistance X minute volume was higher in cattle than in other domestic mammals. The regression equation, giving the best fit of the data, was selected for each PFV. [less ▲]

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See detailEffect of somatic growth, strain and sex on double-chamber plethymosgraphic respiratory function values in healthy mice
Flandre, Th.; Leroy, Pascal ULiege; Desmecht, Daniel ULiege

in Journal of Applied Physiology (2003), 94(3), 1129-1136

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See detailEffect of somatic growth, strain and sex on double-chamber plethysmographic respiratory function values in healthy mice
Flandre, Thierry; Leroy, Pascal ULiege; Desmecht, Daniel ULiege

in Journal of Applied Physiology (2003), 94

Double-chamber plethysmography has been recognized since 1979 as a reference technique to measure pulmonary function values in guinea pigs, but it has not gained attention for use in mice. Theoretically ... [more ▼]

Double-chamber plethysmography has been recognized since 1979 as a reference technique to measure pulmonary function values in guinea pigs, but it has not gained attention for use in mice. Theoretically, however, this technique combines the advantages of single-chamber plethysmography with a quantitative assessment of flow and/or volume and a calculated resistance, the interpretation of which in terms of bronchoconstriction is not disputed. Here we show that, when appropriately preconditioned, mice are able to gradually grow accustomed to the apparatus and display extremely stable nasal and thoracoabdominal flow tracings. Overall, strain, sex, and somatic growth had a significant effect on pulmonary function values. The changes in specific airway resistance (sRaw) and enhanced pause (Penh) values were never in the same direction, indicating that they measure different things. The respiratory frequency was far higher in C57BL/6 compared with BALB/c mice. Peak flows, minute volume, specific tidal and minute volumes, and sRaw were also higher, but Penh was smaller. Males breathed at a higher frequency than females, leading to a higher minute volume. Nevertheless, the specific volumes were considerably higher among females. Penh was lower in males, whereas sRaw was identical in both sexes. Changes associated with somatic growth were rapid and important between 5 and 9 wk, then slowed down between 9 and 12-13 wk and became almost imperceptible after. [less ▲]

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See detailEffect of some extrusion parameters on ruminal and intestinal in sacco disappearance of pea (Pisum sativum) proteins ans starch.
Thewis, André ULiege; Walhain, P.; Foucart, M.

in First European Conference of Grain Legumes, Angers (Fr), June 1-3, 1992 (1992, June)

Detailed reference viewed: 9 (0 ULiège)