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See detailExpression, purification, crystallization and preliminary X-ray crystallographic studies of a psychrophilic cellulase from Pseudoalteromonas haloplanktis
Violot, S.; Haser, R.; Sonan, G. et al

in Acta Crystallographica Section D-Biological Crystallography (2003), 59(Part 7), 1256-1258

The Antarctic psychrophile Pseudoalteromonas haloplanktis produces a cold-active cellulase. To date, a three-dimensional structure of a psychrophilic cellulase has been lacking. Crystallographic studies ... [more ▼]

The Antarctic psychrophile Pseudoalteromonas haloplanktis produces a cold-active cellulase. To date, a three-dimensional structure of a psychrophilic cellulase has been lacking. Crystallographic studies of this cold-adapted enzyme have therefore been initiated in order to contribute to the understanding of the molecular basis of the cold adaptation and the high catalytic efficiency of the enzyme at low and moderate temperatures. The catalytic core domain of the psychrophilic cellulase CelG from P. haloplanktis has been expressed, purified and crystallized and a complete diffraction data set to 1.8 Angstrom has been collected. The space group was found to be P2(1)2(1)2(1), with unit-cell parameters a = 135.1, b = 78.4, c = 44.1 Angstrom. A molecular-replacement solution, using the structure of the mesophilic counterpart Cel5A from Erwinia chrysanthemi as a search model, has been found. [less ▲]

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See detailExpressions correctes de l'heure et des coordonnées des Étoiles dans le système de l'axe instantané
Folie, François ULiege

in Monthly Notices of the Royal Astronomical Society (1903), 63

The author wants to show that the use of the instantaneous axis system is an error for the correct expression of the hour.

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See detailLes expressions correctes de la nutation eulérienne rapportée aux axes instantanés
Folie, François ULiege

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1900), 7

The author’s communication on the correct expressions of the Eulerian nutation reported to instantaneous axis.

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See detailExpressions et territoires politico-religieux- le cas des Eglises de Réveil (RDC et diaspora
Demart, Sarah ULiege

Scientific conference (2011, December 12)

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See detailExpressions verbales de la présence française en Italie entre xve et xvie siècles
Dumont, Jonathan ULiege

in Vissière, Laurent; Hablot, Laurent (Eds.) Cris, Jurons et Chansons. Entendre les « paysages sonores » du Moyen Age et de la Renaissance (2015)

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See detailExpropriation et reconnaissance de zone pour l'aménagement de la zone d'activité économique des Hauts-Sarts 4 Oupeye/Herstal
Bredo, Raphaël; Hanocq, Philippe ULiege; SEREMET, Mariana

Report (2012)

Le projet vise à permettre l'extension de la Zone d'Activités Economiques des Hauts-Sarts sur +/- 60 ha. Le projet porte sur une enclave située entre l’actuel parc industriel des Hauts-Sarts (500 Ha / 9 ... [more ▼]

Le projet vise à permettre l'extension de la Zone d'Activités Economiques des Hauts-Sarts sur +/- 60 ha. Le projet porte sur une enclave située entre l’actuel parc industriel des Hauts-Sarts (500 Ha / 9.000 emplois) et les noyaux d’habitat d’Oupeye et de Hermée. Le dossier prend en compte les principales contraintes du site (environnement, mobilité, planologie, ...) et propose des solutions d'aménagement optimalisées en fonction de ces paramètres, tout en répondant au programme du développeur. [less ▲]

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See detailThe Expropriation of YPF from Repsol in the Argentine Press: Analyzing Framing in Opinion Pieces through Rhetorical Criticism
Azpíroz Manero, María Luisa ULiege

in Doxa Comunicación : Revista Interdisciplinar de Estudios de Comunicación y Ciencias Sociales (2015), (21), 33-53

This article examines how opinion articles in the Argentine press framed the government's expropriation of Yacimientos Petrolíferos Fiscales (YPF) from Repsol in 2012. By understanding frames as ... [more ▼]

This article examines how opinion articles in the Argentine press framed the government's expropriation of Yacimientos Petrolíferos Fiscales (YPF) from Repsol in 2012. By understanding frames as narratives composed by the interrelation of the functions of frame, and adopting Kuper's proposal to analyze framing from the perspective of rhetorical criticism, this study focuses on two newspapers with opposing editorial lines (La Nación and Página 12) and identifies two different narratives shaping the reporting of this story. The results also reveal two different views of the role of the market and the state in the economy and in the management of energy resources. [less ▲]

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See detailExpropriations d'extrême urgence
Delnoy, Michel ULiege

in Immoblier (1998), 2

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See detailExpulsion of a uterine myoma in a patient treated with ulipristal acetate
CHANTRAINE, Frédéric ULiege; POISMANS, Gaëlle ULiege; Nwachuku, Julia et al

in Clinical Case Reports (2015)

Description of a spontaneous expulsion of a submucosal myoma in a patient treated with ulipristal acetate.

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See detailExtant diversity of bryophytes emerged from successive post-Mesozoic diversification bursts
Laenen, B.; Shaw, B.; Schneider, H. et al

in Nature Communications (2014), 5

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See detailExtase en ontnuchtering. Guido Gezelle en Herman de Coninck beyond discourse
Spinoy, Erik ULiege

in Gezelliana (2003), (1), 45-71

A comparison of the literary views of the 19th-century romantic poet Guido Gezelle and his 20th-century counterpart Guido Gezelle reveal a series of striking resemblances, which are discussed in this ... [more ▼]

A comparison of the literary views of the 19th-century romantic poet Guido Gezelle and his 20th-century counterpart Guido Gezelle reveal a series of striking resemblances, which are discussed in this article. [less ▲]

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See detailExtended adjuvant endocrine therapy. Who benefits ? For how long ?
JERUSALEM, Guy ULiege

Conference (2014, April 24)

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See detailExtended adjuvant intermittent letrozole versus continuous letrozole in postmenopausal women with breast cancer (SOLE): a multicentre, open-label, randomised, phase 3 trial.
Colleoni, Marco; Luo, Weixiu; Karlsson, Per et al

in Lancet Oncology (2018), 19(1), 127-138

BACKGROUND: In animal models of breast cancer, resistance to continuous use of letrozole can be reversed by withdrawal and reintroduction of letrozole. We therefore hypothesised that extended intermittent ... [more ▼]

BACKGROUND: In animal models of breast cancer, resistance to continuous use of letrozole can be reversed by withdrawal and reintroduction of letrozole. We therefore hypothesised that extended intermittent use of adjuvant letrozole would improve breast cancer outcome compared with continuous use of letrozole in postmenopausal women. METHODS: We did the multicentre, open-label, randomised, parallel, phase 3 SOLE trial in 240 centres (academic, primary, secondary, and tertiary care centres) in 22 countries. We enrolled postmenopausal women of any age with hormone receptor-positive, lymph node-positive, and operable breast cancer for which they had undergone local treatment (surgery with or without radiotherapy) and had completed 4-6 years of adjuvant endocrine therapy. They had to be clinically free of breast cancer at enrolment and without evidence of recurrent disease at any time before randomisation. We randomly assigned women (1:1) to treatment groups of either continuous use of letrozole (2.5 mg/day orally for 5 years) or intermittent use of letrozole (2.5 mg/day orally for 9 months followed by a 3-month break in years 1-4 and then 2.5 mg/day during all 12 months of year 5). Randomisation was done by principal investigators or designee at respective centres through the internet-based system of the International Breast Cancer Study Group, was stratified by type of previous endocrine therapy (aromatase inhibitors only vs selective oestrogen receptor modulators only vs both therapies), and used permuted block sizes of four and institutional balancing. No one was masked to treatment assignment. The primary endpoint was disease-free survival, analysed by the intention-to-treat principle using a stratified log-rank test. All patients in the intention-to-treat population who initiated protocol treatment during their period of trial participation were included in the safety analyses. This study is registered with ClinicalTrials.gov, number NCT00553410, and EudraCT, number 2007-001370-88; and long-term follow-up of patients is ongoing. FINDINGS: Between Dec 5, 2007, and Oct 8, 2012, 4884 women were enrolled and randomised after exclusion of patients at a non-adherent centre, found to have inadequate documentation of informed consent, immediately withdrew consent, or randomly assigned to intervention groups in error. 4851 women comprised the intention-to-treat population that compared extended intermittent letrozole use (n=2425) with continuous letrozole use (n=2426). After a median follow-up of 60 months (IQR 53-72), disease-free survival was 85.8% (95% CI 84.2-87.2) in the intermittent letrozole group compared with 87.5% (86.0-88.8) in the continuous letrozole group (hazard ratio 1.08, 95% CI 0.93-1.26; p=0.31). Adverse events were reported as expected and were similar between the two groups. The most common grade 3-5 adverse events were hypertension (584 [24%] of 2417 in the intermittent letrozole group vs 517 [21%] of 2411 in the continuous letrozole group) and arthralgia (136 [6%] vs 151 [6%]). 54 patients (24 [1%] in the intermittent letrozole group and 30 [1%] in the continuous letrozole group) had grade 3-5 CNS cerebrovascular ischaemia, 16 (nine [<1%] vs seven [<1%]) had grade 3-5 CNS haemorrhage, and 40 (19 [1%] vs 21 [1%]) had grade 3-5 cardiac ischaemia. In total, 23 (<1%) of 4851 patients died while on trial treatment (13 [<1%] of 2417 patients in the intermittent letrozole group vs ten [<1%] of 2411 in the continuous letrozole group). INTERPRETATION: In postmenopausal women with hormone receptor-positive breast cancer, extended use of intermittent letrozole did not improve disease-free survival compared with continuous use of letrozole. An alternative schedule of extended adjuvant endocrine therapy with letrozole, including intermittent administration, might be feasible and the results of the SOLE trial support the safety of temporary treatment breaks in selected patients who might require them. FUNDING: Novartis and the International Breast Cancer Study Group. [less ▲]

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See detailExtended Analysis of the Highly Ionized Neon Spectra
Kramida, A. E.; Bastin, Thierry ULiege; Biémont, Emile ULiege et al

Poster (1999)

Detailed reference viewed: 10 (3 ULiège)