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See detailDie exokrine Pankreasfunktion beim kranken Pferd
Sandersen, Charlotte ULiege; Serteyn, Didier ULiege; Grulke, Sigrid ULiege

in Vervuert; Achenbach; Gäbel (Eds.) et al LBH, Proccedings 5. Leipziger Tieraerzte Tag (2009)

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See detail"Exolysosomes", Enzyme-Containing Vesicles in the Ecdysial Space of Molting Crabs
Compère, Philippe ULiege; Bouchtia, Hicham; Thiry, Marc ULiege et al

in Journal of Structural Biology (1997), 119(3), 247-59

Free vesicle-like bodies (VLBs) present in the ecdysial space of cuticle regions undergoing degradation during preecdysis of the Atlantic shore crab Carcinus maenas have been interpreted either as ... [more ▼]

Free vesicle-like bodies (VLBs) present in the ecdysial space of cuticle regions undergoing degradation during preecdysis of the Atlantic shore crab Carcinus maenas have been interpreted either as infectious organisms or as secretion structures associated with degradation of the old cuticle. Ultrastructural, cytochemical, and immunocytological investigations were performed to test these hypotheses and to see whether VLBs are peculiar to this crab species. Similar VLBs were systematically found in two other preecdysial crabs, Cancer pagurus and Macropipus puber. In Car, maenas, they originate during early premolt inside Golgi buddings and are often gathered into large vacuoles in epidermal cells. The histochemical azo-dye technique and a cerium-based cytochemical method revealed acid phosphatase activity in both the ecdysial space and the VLBs, while Feulgen's method and immunocytological labeling always failed to reveal any DNA or RNA in either the ecdysial space or the VLBs. We conclude that VLBs are not infectious organisms but "extracellular" cuticle-degrading organelles of lysosomal origin and propose to coin them "exolysosomes." [less ▲]

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See detailExoMars : L’Europe en route vers Mars !
Stiepen, Arnaud ULiege

Article for general public (2016)

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See detailExome copy number variation detection: Use of a pool of unrelated healthy tissue as reference sample
Wenric, Stéphane ULiege; Sticca, Tiberio ULiege; CABERG, Jean-Hubert ULiege et al

in Genetic Epidemiology (2017)

An increasing number of bioinformatic tools designed to detect CNVs (copy number variants) in tumor samples based on paired exome data where a matched healthy tissue constitutes the reference have been ... [more ▼]

An increasing number of bioinformatic tools designed to detect CNVs (copy number variants) in tumor samples based on paired exome data where a matched healthy tissue constitutes the reference have been published in the recent years. The idea of using a pool of unrelated healthy DNA as reference has previously been formulated but not thoroughly validated. As of today, the gold standard for CNV calling is still aCGH but there is an increasing interest in detecting CNVs by exome sequencing. We propose to design a metric allowing the comparison of two CNV profiles, independently of the technique used and assessed the validity of using a pool of unrelated healthy DNA instead of a matched healthy tissue as reference in exome-based CNV detection. We compared the CNV profiles obtained with three different approaches (aCGH, exome sequencing with a matched healthy tissue as reference, exome sequencing with a pool of eight unrelated healthy tissue as reference) on three multiple myeloma samples. We show that the usual analyses performed to compare CNV profiles (deletion/amplification ratios and CNV size distribution) lack in precision when confronted with low LRR values, as they only consider the binary status of each CNV. We show that the metric-based distance constitutes a more accurate comparison of two CNV profiles. Based on these analyses, we conclude that a reliable picture of CNV alterations in multiple myeloma samples can be obtained from whole-exome sequencing in the absence of a matched healthy sample. [less ▲]

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See detailExome sequencing in Brown-Vialetto-van Laere syndrome.
Johnson, Janel O; Gibbs, J Raphael; Van Maldergem, Lionel ULiege et al

in American Journal of Human Genetics (2010), 87(4), 567-9569-70

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See detailExome sequencing of tumors: relevance in copy-number alteration (CNA) analysis and fixed tissue samples.
Wenric, Stéphane ULiege; JOSSE, Claire ULiege; Fasquelle, Corinne ULiege et al

Poster (2013, March 15)

Genomic DNA has been extracted from both cryopreserved and formalin-fixed paraffin-embedded forms of 2 different tumor samples (triple negative, and Her2+). Exome sequencing has been performed on all 4 ... [more ▼]

Genomic DNA has been extracted from both cryopreserved and formalin-fixed paraffin-embedded forms of 2 different tumor samples (triple negative, and Her2+). Exome sequencing has been performed on all 4 forms, as well as SNP and CNA detection. A comparison of the various metrics and results related to the sequencing, mapping, and variants detection has been done, outlining what can, and can’t be done with exome data sequenced from cryopreserved and FFPE tissue. [less ▲]

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See detailExonic deletions in AUTS2 cause a syndromic form of intellectual disability and suggest a critical role for the C terminus.
Beunders, Gea; Voorhoeve, Els; Golzio, Christelle et al

in American journal of human genetics (2013), 92(2), 210-20

Genomic rearrangements involving AUTS2 (7q11.22) are associated with autism and intellectual disability (ID), although evidence for causality is limited. By combining the results of diagnostic testing of ... [more ▼]

Genomic rearrangements involving AUTS2 (7q11.22) are associated with autism and intellectual disability (ID), although evidence for causality is limited. By combining the results of diagnostic testing of 49,684 individuals, we identified 24 microdeletions that affect at least one exon of AUTS2, as well as one translocation and one inversion each with a breakpoint within the AUTS2 locus. Comparison of 17 well-characterized individuals enabled identification of a variable syndromic phenotype including ID, autism, short stature, microcephaly, cerebral palsy, and facial dysmorphisms. The dysmorphic features were more pronounced in persons with 3'AUTS2 deletions. This part of the gene is shown to encode a C-terminal isoform (with an alternative transcription start site) expressed in the human brain. Consistent with our genetic data, suppression of auts2 in zebrafish embryos caused microcephaly that could be rescued by either the full-length or the C-terminal isoform of AUTS2. Our observations demonstrate a causal role of AUTS2 in neurocognitive disorders, establish a hitherto unappreciated syndromic phenotype at this locus, and show how transcriptional complexity can underpin human pathology. The zebrafish model provides a valuable tool for investigating the etiology of AUTS2 syndrome and facilitating gene-function analysis in the future. [less ▲]

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See detailExophtalmie dysthyroïdienne : intérêt de l'abord coronal
XHAUFLAIRE, Gaël ULiege

Conference (2017, May 08)

Bien qu’aucun consensus strict ne soit défini, la tendance actuelle en chirurgie de l'exophtalmie dysthyroidienne, comme dans toute chirurgie, est à la petite incision. Il est toutefois utile de rappeler ... [more ▼]

Bien qu’aucun consensus strict ne soit défini, la tendance actuelle en chirurgie de l'exophtalmie dysthyroidienne, comme dans toute chirurgie, est à la petite incision. Il est toutefois utile de rappeler l’intérêt de l’abord coronal dans le traitement périorbitaire global de l’orbitopathie dysthyroïdienne. L'abord coronal permet un effondrement complet et efficace de 3 à 4 parois bilatérales. Il peut être associé à une lipectomie, à des greffes osseuses, voire à une reconstruction crânio-faciale plus complète, en un seul temps opératoire. L'effondrement de la paroi externe de l'orbite peut être réalisée sans pression sur le globe, et donc à moindre risque pour un oeil fragilisé par une myopie forte ou des chirurgies antérieures. La chirurgie ethmoïdale centrifuge expose à moins de risques de grasping musculaire qu'une chirurgie endonasale. La chirurgie s'effectuant du haut vers le bas expose à moins de risques de pénétration méningée et de fuite de LCR. La décompression "balancée", avec conservation du plancher médian et du ROOT expose à moins de risque de diplopie incoercible et à un moindre risque d'anesthésie trigéminée définitive. En présence d'une exophtalmie forte et d'un orbite congestif, fibreux, cicatriciel, d'un globe fragile, voire d'une sinusopathie, l'abord coronal sera parfois le seul possible. [less ▲]

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See detailExophthalmos and strabismus associated with a frontal mucocele in a 6-month-old puppy
Monclin, Sébastien ULiege; Saulnier-Troff F.; Bolen, Géraldine ULiege et al

Poster (2008, May)

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See detailExoplanet Characterization and the Search for Life
Kasting, James; Traub, W.; Roberge, A. et al

E-print/Working paper (2009)

Over 300 extrasolar planets (exoplanets) have been detected orbiting nearby stars. We now hope to conduct a census of all planets around nearby stars and to characterize their atmospheres and surfaces ... [more ▼]

Over 300 extrasolar planets (exoplanets) have been detected orbiting nearby stars. We now hope to conduct a census of all planets around nearby stars and to characterize their atmospheres and surfaces with spectroscopy. Rocky planets within their star's habitable zones have the highest priority, as these have the potential to harbor life. Our science goal is to find and characterize all nearby exoplanets; this requires that we measure the mass, orbit, and spectroscopic signature of each one at visible and infrared wavelengths. The techniques for doing this are at hand today. Within the decade we could answer long-standing questions about the evolution and nature of other planetary systems, and we could search for clues as to whether life exists elsewhere in our galactic neighborhood. [less ▲]

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See detailExoplanet discoveries with the CoRoT space observatory
Lammer, H.; Dvorak, R.; Deleuil, M. et al

in Solar System Research (2010), 44

The CoRoT space observatory is a project which is led by the French space agency CNES and leading space research institutes in Austria, Brazil, Belgium, Germany and Spain and also the European Space ... [more ▼]

The CoRoT space observatory is a project which is led by the French space agency CNES and leading space research institutes in Austria, Brazil, Belgium, Germany and Spain and also the European Space Agency ESA. CoRoT observed since its launch in December 27, 2006 about 100 000 stars for the exoplanet channel, during 150 days uninterrupted high-precision photometry. Since the The CoRoT-team has several exoplanet candidates which are currently analyzed under its study, we report here the discoveries of nine exoplanets which were observed by CoRoT. Discovered exoplanets such as CoRoT-3b populate the brown dwarf desert and close the gap of measured physical properties between usual gas giants and very low mass stars. CoRoT discoveries extended the known range of planet masses down to about 4.8 Earth-masses (CoRoT-7b) and up to 21 Jupiter masses (CoRoT-3b), the radii to about 1.68 × 0.09 R [SUB]Earth[/SUB] (CoRoT-7b) and up to the most inflated hot Jupiter with 1.49 × 0.09 R [SUB]Earth[/SUB] found so far (CoRoT-1b), and the transiting exoplanet with the longest period of 95.274 days (CoRoT-9b). Giant exoplanets have been detected at low metallicity, rapidly rotating and active, spotted stars. Two CoRoT planets have host stars with the lowest content of heavy elements known to show a transit hinting towards a different planethost-star-metallicity relation then the one found by radial-velocity search programs. Finally the properties of the CoRoT-7b prove that rocky planets with a density close to Earth exist outside the Solar System. Finally the detection of the secondary transit of CoRoT-1b at a sensitivity level of 10[SUP]-5[/SUP] and the very clear detection of the "super-Earth" CoRoT-7b at 3.5 × 10[SUP]-4[/SUP] relative flux are promising evidence that the space observatory is being able to detect even smaller exoplanets with the size of the Earth. [less ▲]

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See detailExoplanet imaging with mid-infrared vector vortex coronagraphs: design, manufacture, validation and first light of the annular groove phase mask
Delacroix, Christian ULiege

Doctoral thesis (2013)

During the past twenty years, detections of extrasolar planets have flourished and grown expo- nentially, reaching almost 900 confirmed exoplanets so far. This number is doubling every two or three years ... [more ▼]

During the past twenty years, detections of extrasolar planets have flourished and grown expo- nentially, reaching almost 900 confirmed exoplanets so far. This number is doubling every two or three years. The most recent discoveries made by the Kepler mission have revealed two Earth- size exoplanets orbiting the same star, and fulfilling all the required conditions to be habitable. Imaging techniques have also come a long way. Since the first direct detection in 2004, some stunning exoplanet pictures have been captured at the telescope under special circumstances of moderate contrast and/or angular separation, thanks to the advent and continuous improvement of adaptive optics systems and data reduction methods. In this broad context, the need for high contrast imaging techniques with very small inner working angles has never been so strong. Coro- nagraphy has a key role to play in order to provide the means necessary for imaging Earth-size planets, and try to answer the recurring question of the possible presence of life outside the solar system. The present thesis is dedicated to the development of the annular groove phase mask (AGPM), a specific type of broadband vector vortex coronagraph based on subwavelength gratings. Consid- ered for several years as one of the best solutions for building high-performance mid-infrared coron- agraphs with small inner working angles, the AGPM has never been validated up to now. Although various fabrication processes are available, depending on the substrates and micro-lithography techniques considered, they often face extremely challenging constraints. In the present work, we explored the feasibility of achromatic micro-components made out of subwavelength gratings, for which two technological solutions are followed: quartz and diamond. As we focussed on the diamond option, its unique material properties making it a prime candidate for mid-infrared ap- plications, we managed to develop mid-infrared broadband half-wave plates, ideally optimized to enable the manufacturing of charge-2 vortices. Following this success, we continued our devel- opments leading to the fabrication of several AGPMs for two astronomic windows, the L and N bands, and we successfully validated several L-band AGPMs on a coronagraphic test bench at the Observatoire de Paris. In the last chapter, we expose the recent installation of our components on three world-class infrared cameras, VISIR and NACO at the Very Large Telescope in Chile, and LMIRCam at the Large Binocular Telescope in Arizona. We conclude with the very first on-sky results of both N-band and L-band AGPMs, and the discovery and successful imaging of a faint stellar companion at two beamwidths from an F-type star. [less ▲]

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See detailExoplanet science with the LBTI: instrument status and plans
Defrere, Denis ULiege; Hinz, P.; Skemer, A. et al

in Shaklan, Stuart (Ed.) Techniques and Instrumentation for Detection of Exoplanets VII (2015, September 16)

The Large Binocular Telescope Interferometer (LBTI) is a strategic instrument of the LBT designed for high-sensitivity, high-contrast, and high-resolution infrared (1.5-13 $\mu$m) imaging of nearby ... [more ▼]

The Large Binocular Telescope Interferometer (LBTI) is a strategic instrument of the LBT designed for high-sensitivity, high-contrast, and high-resolution infrared (1.5-13 $\mu$m) imaging of nearby planetary systems. To carry out a wide range of high-spatial resolution observations, it can combine the two AO-corrected 8.4-m apertures of the LBT in various ways including direct (non-interferometric) imaging, coronagraphy (APP and AGPM), Fizeau imaging, non-redundant aperture masking, and nulling interferometry. It also has broadband, narrowband, and spectrally dispersed capabilities. In this paper, we review the performance of these modes in terms of exoplanet science capabilities and describe recent instrumental milestones such as first-light Fizeau images (with the angular resolution of an equivalent 22.8-m telescope) and deep interferometric nulling observations. [less ▲]

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See detailExoplanetary Transits
Gillon, Michaël ULiege

Scientific conference (2017, September 15)

Exoplanetary Transits

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See detailExoplanètes jeunes - 09/2016
Manfroid, Jean ULiege

Article for general public (2016)

HD 131399Ab - V830 Tauri - K2-33b

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See detailExopolysaccharides production by selected bacteria
Valepyn, Emmanuel ULiege; Paquot, Michel ULiege; Nys, Joël

Poster (2011, August)

Detailed reference viewed: 22 (2 ULiège)