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See detailEvidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.
Laukens, Debby; Georges, Michel ULiege; Libioulle, Cécile ULiege et al

in PLoS ONE (2010), 5(11), 13795

BACKGROUND: A multicenter genome-wide association scan for Crohn's Disease (CD) has recently reported 40 CD susceptibility loci, including 29 novel ones (19 significant and 10 putative). To gain insight ... [more ▼]

BACKGROUND: A multicenter genome-wide association scan for Crohn's Disease (CD) has recently reported 40 CD susceptibility loci, including 29 novel ones (19 significant and 10 putative). To gain insight into the genetic overlap between CD and ankylosing spondylitis (AS), these markers were tested for association in AS patients. PRINCIPAL FINDINGS: Two previously established associations, namely with the MHC and IL23R loci, were confirmed. In addition, rs2872507, which maps to a locus associated with asthma and influences the expression of the ORMDL3 gene in lymphoblastoid cells, showed a significant association with AS (p = 0.03). In gut biopsies of AS and CD patients, ORMDL3 expression was not significantly different from controls and no correlation was found with the rs2872507 genotype (Spearman's rho: -0.067). The distribution of p-values for the remaining 36 SNPs was significantly skewed towards low p-values unless the top 5 ranked SNPs (ORMDL3, NKX2-3, PTPN2, ICOSLG and MST1) were excluded from the analysis. CONCLUSIONS: Association analysis using risk variants for CD led to the identification of a new risk variant associated with AS (ORMDL3), underscoring a role for ER stress in AS. In addition, two known and five potentially relevant associations were detected, contributing to common susceptibility of CD and AS. [less ▲]

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See detailEvidence For Soil Water Control On Carbon And Water Dynamics In European Forests During The Extremely Dry Year: 2003
Granier, A.; Reichstein, M.; Breda, N. et al

in Agricultural and Forest Meteorology (2007), 143(1-2),

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See detailEvidence For Specific And Non-Covalent Binding Of Lipids To Natural And Recombinant Mycobacterium Bovis Bcg Hsp60 Proteins, And To The Escherichia Coli Homologue Groel
De Bruyn, J.; Soetaert, K.; Buyssens, P. et al

in Microbiology-Sgm (2000), 146

Heat-shock proteins (Hsps) from various origins are known to share a conserved structure and are assumed to be key partners in the biogenesis of proteins. Fractionation of the mycobacterial Hsp60, a 65 ... [more ▼]

Heat-shock proteins (Hsps) from various origins are known to share a conserved structure and are assumed to be key partners in the biogenesis of proteins. Fractionation of the mycobacterial Hsp60, a 65 kDa protein also called Cpn60, from Mycobacterium bovis BCG zinc-deficient culture filtrate on phenyl-Sepharose followed by Western blotting revealed the existence of four Hsp60-1 and Hsp60-2 forms, based on their hydrophobicity behaviour. Hsp60-2 species were further purified by ion-exchange chromatography and partial amino acid sequences of cyanogen bromide (CNBr) peptides of purified Hsp60-2 species showed identity with the amino acid sequence deduced from the hsp60-2 gene, indicating that the various Hsp60-2 forms are encoded by the same gene. In addition, the mycobacterial Hsp60-2 was overexpressed in E. coli using the pRR3Hsp60-2 plasmid and analysed on phenyl-Sepharose. The elution pattern of the recombinant Hsp60-2, as well as that of Escherichia coli GroEL, was similar to that of the native Hsp60-2 from the culture filtrate of M. bovis BCG and entirely different from that of the mycobacterial antigen 85. Extraction of mycobacterial Hsp60-2 forms, recombinant BCG Hsp60-2 and E. coli GroEL with organic solvents releases various amounts of non-covalently bound lipids. The presence of lipids on Hsp60-2 was confirmed by labelling M. bovis BCG with radioactive palmitate. The radioactivity was specifically associated with Hsp60 in the aqueous phase and the 19 and 38 kDa lipoproteins in the Triton X-114 phase. Analysis of the lipids extracted from purified Hsp60-2, recombinant BCG Hsp60-2 and E. coli GroEL by TLC showed the same pattern for all the samples. Acid methanolysis of the lipids followed by GC analysis led to the identification of C(16:0), C(18:0) and C(18:1) as the major fatty acyl constituents, and of methylglycoside in these proteins. Altogether, these data demonstrate that lipids are non-covalently bound to Hsp60-2 and homologous proteins. [less ▲]

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See detailEvidence for the alignment of quasar radio polarizations with large quasar group axes
Pelgrims, Vincent ULiege; Hutsemekers, Damien ULiege

in Astronomy and Astrophysics (2016), 590

Recently, evidence has been presented for the polarization vectors from quasars to preferentially align with the axes of the large quasar groups (LQG) to which they belong. This report was based on ... [more ▼]

Recently, evidence has been presented for the polarization vectors from quasars to preferentially align with the axes of the large quasar groups (LQG) to which they belong. This report was based on observations made at optical wavelengths for two large quasar groups at redshift ~1.3. The correlation suggests that the spin axes of quasars preferentially align with their surrounding large-scale structure that is assumed to be traced by the LQGs. Here, we consider a large sample of LQGs built from the Sloan Digital Sky Survey DR7 quasar catalogue in the redshift range 1.0 -􀀀 1.8. For quasars embedded in this sample, we collected radio polarization measurements with the goal to study possible correlations between quasar polarization vectors and the major axis of their host LQGs. Assuming the radio polarization vector is perpendicular to the quasar spin axis, we found that the quasar spin axis is preferentially parallel to the LQG major axis inside LQGs that have at least 20 members. This result independently supports the observations at optical wavelengths. We additionally found that when the richness of an LQG decreases, the quasar spin axis becomes preferentially perpendicular to the LQG major axis and that no correlation is detected for quasar groups with fewer than 10 members. [less ▲]

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See detailEvidence For The Assignment Of Two Strains Of Splv To The Genus Potyvirus Based On Coat Protein And 3' Non-Coding Region Sequence Data
Colinet, Dominique; Kummert, Jean; Lepoivre, Philippe ULiege

in Virus Research (1997), 49(1), 91-100

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See detailEvidence for the association between human thymic MHC class I molecules and a dominant neurohypophysial thymic peptide
Geenen, Vincent ULiege; Vandersmissen, Eric; Martens, Henri ULiege et al

in Journal of Immunology (1993), 150

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See detailEvidence for the domains supporting the construct of intrinsic capacity.
Cesari, Matteo; Araujo de Carvalho, Islene; Amuthavalli Thiyagarajan, Jotheeswaran et al

in Journals of Gerontology. Series A, Biological Sciences and Medical Sciences (2018)

Healthy ageing can be defined as “the process of developing and maintaining the functional ability that enables wellbeing in older age”. Functional ability (i.e., the health-related attributes that enable ... [more ▼]

Healthy ageing can be defined as “the process of developing and maintaining the functional ability that enables wellbeing in older age”. Functional ability (i.e., the health-related attributes that enable people to be and to do what they have reason to value) is determined by intrinsic capacity (i.e., the composite of all the physical and mental capacities of an individual), the environment (i.e., all the factors in the extrinsic world that form the context of an individual’s life), and the interactions between the two. This innovative model recently proposed by the World Health Organization has the potential to substantially modify the way in which clinical practice is currently conducted, shifting from disease-centered towards function-centered paradigms. By overcoming the multiple limitations affecting the construct of disease, this novel framework may allow the worldwide dissemination of a more proactive and function-based approach towards achieving optimal health status. In order to facilitate the translation of the current theoretical model into practice, it is important to identify the inner nature of its constituting constructs. In this paper, we consider intrinsic capacity. Using the International Classification of Functioning, Disability and Health (ICF) framework as background and taking into account available evidence, five domains (i.e., locomotion, vitality, cognition, psychological, sensory) are identified as pivotal for capturing the individual’s intrinsic capacity (and therefore also reserves) and, through this, pave the way for its objective measurement. [less ▲]

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See detailEvidence for the efficacy of preventive means for low back pain
Muller, G; Burton, AK; Balague, F et al

in Physioscience (2005), 1

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See detailEvidence for the existence of pathogenicity determinants in the Long Terminal Repeats (LTRs) of the Bovine Leukemia Virus (BLV) genome
Rodriguez, Sabrina ULiege; Trono, K.; Jones, L.R.

in AIDS Research and Human Retroviruses (2011), 8(1), 26

Evidence for the existence of pathogenicity determinants in the Long Terminal Repeats (LTRs) of the Bovine Leukemia Virus (BLV) genome Sabrina M. Rodríguez1*, Karina Trono2, Leandro R. Jones3 1 Molecular ... [more ▼]

Evidence for the existence of pathogenicity determinants in the Long Terminal Repeats (LTRs) of the Bovine Leukemia Virus (BLV) genome Sabrina M. Rodríguez1*, Karina Trono2, Leandro R. Jones3 1 Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA) , University of Liège (ULg), Belgium. 2 Instituto de Virología, CICVyA, Instituto Nacional de Tecnología Agropecuaria INTA-Castelar, CC 25 (1712), Castelar. 3 División de Biología Molecular, Estación de Fotobiología Playa Unión, CC 15, Rawson, Chubut 9103, Argentina. *E-mail: sabrina.rodriguez@ulg.ac.be The majority of BLV-infected animals are asymptomatic carriers (AL) while about 30% develop a benign persistent lymphocytosis (PL). Fatal lymphosarcoma (LS) occurs in 5% of infected animals. The genetic basis of these diverse outcomes of BLV infection is still unknown. Viral LTRs constitute a genetic determinant of pathogenesis for other retroviruses. However, this possibility has never been tested for BLV. Analyses to test correlation between clinical and genotypic traits across species must be corrected by including the group phylogeny. Otherwise, shared evolutionary history can jeopardize statistical independence. Thus, the influence of BLV LTR genetic variation on the clinical manifestation of the disease was investigated by employing Cladistic and Probabilistic, phylogenetic comparative methods. With this purpose, the 5´LTR region of 40 BLV proviruses from bovines with different clinical presentations (AL, PL, LS) was sequenced. Seven polymorphic positions showing an apparent association with the clinical presentation were identified. A provirus phylogeny was obtained using env gene sequences from 28 of the 40 provirus studied in this work. Both Cladistic and Probabilistic comparative analyses based on the empirical sequence alignment and the provirus phylogeny suggested that positions 41 and 56 might be correlated to the clinical presentation. The probabilistic analysis further indicated an association with the viral pathogenesis for positions 373, 450, 494 and 505, though the corresponding statistical supports were lower in comparison to the supports obtained for positions 41 and 56. These observations indicate that the BLV LTRs might contain pathogenicity determinants. [less ▲]

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See detailEvidence for the expression of growth hormone receptors in human placenta
Frankenne, Francis; Alsat, Eliane; Scippo, Marie-Louise ULiege et al

in Biochemical and Biophysical Research Communications (1992), 182(2), 481-486

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See detailEvidence For The Occurrence Of Endophytic Prokaryotic Contaminants In Micropropogated Plantlets Of Prunus Cerasus Cv. 'Montmorency'
Kamoun, R.; Lepoivre, Philippe ULiege; Boxus, P.

in Plant Cell, Tissue & Organ Culture (1998), 52(1-2),

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See detailEvidence for the presence of N-methyl-D-aspartate receptors in the ventral tegmental area of the rat : an electrophysiological in vitro study
Seutin, Vincent ULiege; Verbanck, Paul; Massotte, Laurent ULiege et al

in Brain Research (1990), 514(1), 147-150

Extracellular recordings were obtained from spontaneously active, presumed dopaminergic neurons of the ventral tegmental area (VTA) of the rat in a slice preparation. Bath-applied N-methyl-D-aspartate ... [more ▼]

Extracellular recordings were obtained from spontaneously active, presumed dopaminergic neurons of the ventral tegmental area (VTA) of the rat in a slice preparation. Bath-applied N-methyl-D-aspartate (NMDA) (1-20 microM) activated all neurons tested (n = 36). This effect was clearly concentration-dependent (n = 14), quickly reversible and reproducible. No bursting type of discharge was observed during NMDA infusion. The NMDA receptor blocker DL-2-amino-5-phosphonovaleric acid (50 microM) reversibly antagonized the increase in cell firing produced with 10 microM NMDA by 83.5 +/- 3% (mean +/- S.E.M.) (n = 8, P less than 0.05). Lowering the Mg2+ concentration of the perfusion fluid to one-third of its normal value significantly enhanced the excitatory effect of 5 microM NMDA (n = 7, P less than 0.05), but not of 500 nM carbachol (n = 6). Finally, NMDA did not modify the sensitivity of dopaminergic autoreceptors of VTA neurons (n = 8), when compared to controls (n = 10). These observations strongly support the presence of specific NMDA receptors in the VTA. [less ▲]

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See detailEvidence for the presence of the 802.7 cm−1 band Q branch of HO2NO2 in high resolution solar absorption spectra of the stratosphere
Rinsland, C. P.; Zander, Rodolphe ULiege; Farmer, C. B. et al

in Geophysical Research Letters (1986), 13(8), 761--764

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See detailEvidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.
Hinney, A.; Kesselmeier, M.; Jall, S. et al

in Molecular Psychiatry (2017), 22(2), 192-201

The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range ... [more ▼]

The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we performed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI-related loci was performed in the AN GWAMA. We detected significant associations (P-values <5 x 10-5, Bonferroni-corrected P<0.05) for nine SNP alleles at three independent loci. Interestingly, all AN susceptibility alleles were consistently associated with increased BMI. None of the genes (chr. 10: CTBP2, chr. 19: CCNE1, chr. 2: CARF and NBEAL1; the latter is a region with high linkage disequilibrium) nearest to these SNPs has previously been associated with AN or obesity. Sex-stratified analyses revealed that the strongest BMI signal originated predominantly from females (chr. 10 rs1561589; Poverall: 2.47 x 10-06/Pfemales: 3.45 x 10-07/Pmales: 0.043). Functional ex vivo studies in mice revealed reduced hypothalamic expression of Ctbp2 and Nbeal1 after fasting. Hypothalamic expression of Ctbp2 was increased in diet-induced obese (DIO) mice as compared with age-matched lean controls. We observed no evidence for associations for the look-up of BMI-related loci in the AN GWAMA. A cross-trait analysis of AN and BMI loci revealed variants at three chromosomal loci with potential joint impact. The chromosome 10 locus is particularly promising given that the association with obesity was primarily driven by females. In addition, the detected altered hypothalamic expression patterns of Ctbp2 and Nbeal1 as a result of fasting and DIO implicate these genes in weight regulation. [less ▲]

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See detailEvidence for transplacental transmission of the current wild-type strain of bluetongue virus serotype-8 in cattle
Desmecht, Daniel ULiege; Vanden Bergh, Raphaël ULiege; Sartelet, Arnaud ULiege et al

in Veterinary Record : Journal of the British Veterinary Association (2008), 163

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See detailEvidence for two spatially separated UV continuum emitting regions in the Cloverleaf broad absorption line quasar
Sluse, Dominique ULiege; Hutsemekers, Damien ULiege; Anguita, T. et al

in Astronomy and Astrophysics (2015), 582

Testing the standard Shakura-Sunyaev model of accretion is a challenging task because the central region of quasars where accretion takes place is unresolved with telescopes. The analysis of microlensing ... [more ▼]

Testing the standard Shakura-Sunyaev model of accretion is a challenging task because the central region of quasars where accretion takes place is unresolved with telescopes. The analysis of microlensing in gravitationally lensed quasars is one of the few techniques that can test this model, yielding to the measurement of the size and of temperature profile of the accretion disc. We present spectroscopic observations of the gravitationally lensed broad absorption line quasar H1413+117, which reveal partial microlensing of the continuum emission that appears to originate from two separated regions: a microlensed region, corresponding the compact accretion disc; and a non-microlensed region, more extended and contributing to at least 30% of the total UV-continuum flux. Because this extended continuum is occulted by the broad absorption line clouds, it is not associated with the host galaxy, but rather with light scattered in the neighbourhood of the central engine. We measure the amplitude of microlensing of the compact continuum over the rest-frame wavelength range 1000-7000 Å. Following a Bayesian scheme, we confront our measurements to microlensing simulations of an accretion disc with a temperature varying as T ∝ R[SUP]-1/ν[/SUP]. We find a most likely source half-light radius of R[SUB]1/2[/SUB] = 0.61 × 10[SUP]16[/SUP]cm (i.e., 0.002 pc) at 0.18 μm, and a most-likely index of ν = 0.4. The standard disc (ν = 4/3) model is not ruled out by our data, and is found within the 95% confidence interval associated with our measurements. We demonstrate that, for H1413+117, the existence of an extended continuum in addition to the disc emission only has a small impact on the inferred disc parameters, and is unlikely to solve the tension between the microlensing source size and standard disc sizes, as previously reported in the literature. Based on observations made with ESO Telescopes at the Paranal Observatory (Chile). ESO program ID: 386.B-0337.Appendices A and B are available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201526832/olm">http://www.aanda.org</A> [less ▲]

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See detailEvidence for very large-scale coherent orientations of quasar polarization vectors
Hutsemekers, Damien ULiege

in Astronomy and Astrophysics (1998), 332

On the basis of a new sample of quasar optical polarization measurements, we have found that, in a region of the sky, the quasar polarization vectors are not randomly oriented as naturally expected, but ... [more ▼]

On the basis of a new sample of quasar optical polarization measurements, we have found that, in a region of the sky, the quasar polarization vectors are not randomly oriented as naturally expected, but appear concentrated around one preferential direction. In order to verify this surprising although preliminary result, we have compiled a large sample of quasar polarization measurements from the literature. With quite severe criteria to eliminate at best the contamination by our Galaxy, a sample of 170 quasars with good quality polarization measurements has been defined. Maps in redshift slices reveal a few regions where the polarization vectors are apparently aligned. To handle the problem more quantitatively, non-parametric 3D statistical tests were designed, as well as a method for visualizing spatially the results. The significance is evaluated through Monte-Carlo simulations. Applied to our sample of 170 polarized quasars, two different statistical tests provide evidence, with significance levels of 0.005 and 0.015 respectively, that the optical polarization vectors of quasars are not randomly distributed over the sky but are coherently oriented on very large spatial scales. This orientation effect appears spatially delimited in the 3D Universe, mainly occuring in a few groups of 10-20 objects. The polarization vectors of objects located along the same line of sight but at different redshifts do not appear accordingly aligned. Essentially for this reason, instrumental bias and contamination by interstellar polarization in our Galaxy are unlikely to be responsible for the observed effect. The very large scale at which this local orientation effect is observed indicates the presence of correlations in objects or fields on spatial scales ~ 1000 h(-1) Mpc at redshifts z =~ 1-2, suggesting an effect of cosmological importance. Several possible and testable interpretations are discussed. Tables~2 and 3 are also available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/Abstract.html [less ▲]

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See detailEvidence for violent ejection of nebulae from massive stars
Hutsemekers, Damien ULiege

in Astronomy and Astrophysics (1994), 281(Letters), 81-84

We report the results of a systematic search for nebulae around Luminous Blue Variable LBVs) and the discovery of a strong correlation between the mass of the nebulae and the luminosity of the central ... [more ▼]

We report the results of a systematic search for nebulae around Luminous Blue Variable LBVs) and the discovery of a strong correlation between the mass of the nebulae and the luminosity of the central stars. This correlation holds for both the dust and ionized gas masses of the nebulae. The existence of a 'nebular mass-stellar luminosity' relation and the fact that not all LBVs are presently associated with a nebula give evidence against a continuous mass-loss mechanism for the formation of these nebulae. Further, the good agreement found between the observed relation and predictions by Maeder (1989), suggests that all these nebulae may be due to a violent ejection of matter caused by an instability of structural origin. [less ▲]

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See detailEvidence for vortex staircases in the whole angular range due to competing correlated pinning mechanisms
Silhanek, Alejandro ULiege; Civale, L.; Candia, S. et al

in Physical Review. B : Condensed Matter (1999), 59(21), 13620-13623

We present measurements of the angular dependence of the irreversible magnetization of YBa2Cu3O7 single crystals with columnar defects inclined with respect to the c axis. At high fields a sharp maximum ... [more ▼]

We present measurements of the angular dependence of the irreversible magnetization of YBa2Cu3O7 single crystals with columnar defects inclined with respect to the c axis. At high fields a sharp maximum centered at the tracks direction is observed. At low fields we identify a lock-in phase characterized by an angle-independent pinning strength and observe an angular shift of the peak towards the c axis that originates in the misalignment between vortices and applied field in anisotropic materials. The interplay among columnar defects, twins, and intrinsic pinning by the ab planes generates a variety of staircase structures. We show that correlated pinning dominates for all orientations of the applied field. [S0163-1829(99)09417-5]. [less ▲]

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