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See detailEvidence for the expression of growth hormone receptors in human placenta
Frankenne, Francis; Alsat, Eliane; Scippo, Marie-Louise ULiege et al

in Biochemical and Biophysical Research Communications (1992), 182(2), 481-486

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See detailEvidence For The Occurrence Of Endophytic Prokaryotic Contaminants In Micropropogated Plantlets Of Prunus Cerasus Cv. 'Montmorency'
Kamoun, R.; Lepoivre, Philippe ULiege; Boxus, P.

in Plant Cell, Tissue & Organ Culture (1998), 52(1-2),

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See detailEvidence for the presence of N-methyl-D-aspartate receptors in the ventral tegmental area of the rat : an electrophysiological in vitro study
Seutin, Vincent ULiege; Verbanck, Paul; Massotte, Laurent ULiege et al

in Brain Research (1990), 514(1), 147-150

Extracellular recordings were obtained from spontaneously active, presumed dopaminergic neurons of the ventral tegmental area (VTA) of the rat in a slice preparation. Bath-applied N-methyl-D-aspartate ... [more ▼]

Extracellular recordings were obtained from spontaneously active, presumed dopaminergic neurons of the ventral tegmental area (VTA) of the rat in a slice preparation. Bath-applied N-methyl-D-aspartate (NMDA) (1-20 microM) activated all neurons tested (n = 36). This effect was clearly concentration-dependent (n = 14), quickly reversible and reproducible. No bursting type of discharge was observed during NMDA infusion. The NMDA receptor blocker DL-2-amino-5-phosphonovaleric acid (50 microM) reversibly antagonized the increase in cell firing produced with 10 microM NMDA by 83.5 +/- 3% (mean +/- S.E.M.) (n = 8, P less than 0.05). Lowering the Mg2+ concentration of the perfusion fluid to one-third of its normal value significantly enhanced the excitatory effect of 5 microM NMDA (n = 7, P less than 0.05), but not of 500 nM carbachol (n = 6). Finally, NMDA did not modify the sensitivity of dopaminergic autoreceptors of VTA neurons (n = 8), when compared to controls (n = 10). These observations strongly support the presence of specific NMDA receptors in the VTA. [less ▲]

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See detailEvidence for the presence of the 802.7 cm−1 band Q branch of HO2NO2 in high resolution solar absorption spectra of the stratosphere
Rinsland, C. P.; Zander, Rodolphe ULiege; Farmer, C. B. et al

in Geophysical Research Letters (1986), 13(8), 761--764

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See detailEvidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.
Hinney, A.; Kesselmeier, M.; Jall, S. et al

in Molecular Psychiatry (2017), 22(2), 192-201

The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range ... [more ▼]

The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we performed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI-related loci was performed in the AN GWAMA. We detected significant associations (P-values <5 x 10-5, Bonferroni-corrected P<0.05) for nine SNP alleles at three independent loci. Interestingly, all AN susceptibility alleles were consistently associated with increased BMI. None of the genes (chr. 10: CTBP2, chr. 19: CCNE1, chr. 2: CARF and NBEAL1; the latter is a region with high linkage disequilibrium) nearest to these SNPs has previously been associated with AN or obesity. Sex-stratified analyses revealed that the strongest BMI signal originated predominantly from females (chr. 10 rs1561589; Poverall: 2.47 x 10-06/Pfemales: 3.45 x 10-07/Pmales: 0.043). Functional ex vivo studies in mice revealed reduced hypothalamic expression of Ctbp2 and Nbeal1 after fasting. Hypothalamic expression of Ctbp2 was increased in diet-induced obese (DIO) mice as compared with age-matched lean controls. We observed no evidence for associations for the look-up of BMI-related loci in the AN GWAMA. A cross-trait analysis of AN and BMI loci revealed variants at three chromosomal loci with potential joint impact. The chromosome 10 locus is particularly promising given that the association with obesity was primarily driven by females. In addition, the detected altered hypothalamic expression patterns of Ctbp2 and Nbeal1 as a result of fasting and DIO implicate these genes in weight regulation. [less ▲]

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See detailEvidence for transplacental transmission of the current wild-type strain of bluetongue virus serotype-8 in cattle
Desmecht, Daniel ULiege; Vanden Bergh, Raphaël ULiege; Sartelet, Arnaud ULiege et al

in Veterinary Record : Journal of the British Veterinary Association (2008), 163

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See detailEvidence for two spatially separated UV continuum emitting regions in the Cloverleaf broad absorption line quasar
Sluse, Dominique ULiege; Hutsemekers, Damien ULiege; Anguita, T. et al

in Astronomy and Astrophysics (2015), 582

Testing the standard Shakura-Sunyaev model of accretion is a challenging task because the central region of quasars where accretion takes place is unresolved with telescopes. The analysis of microlensing ... [more ▼]

Testing the standard Shakura-Sunyaev model of accretion is a challenging task because the central region of quasars where accretion takes place is unresolved with telescopes. The analysis of microlensing in gravitationally lensed quasars is one of the few techniques that can test this model, yielding to the measurement of the size and of temperature profile of the accretion disc. We present spectroscopic observations of the gravitationally lensed broad absorption line quasar H1413+117, which reveal partial microlensing of the continuum emission that appears to originate from two separated regions: a microlensed region, corresponding the compact accretion disc; and a non-microlensed region, more extended and contributing to at least 30% of the total UV-continuum flux. Because this extended continuum is occulted by the broad absorption line clouds, it is not associated with the host galaxy, but rather with light scattered in the neighbourhood of the central engine. We measure the amplitude of microlensing of the compact continuum over the rest-frame wavelength range 1000-7000 Å. Following a Bayesian scheme, we confront our measurements to microlensing simulations of an accretion disc with a temperature varying as T ∝ R[SUP]-1/ν[/SUP]. We find a most likely source half-light radius of R[SUB]1/2[/SUB] = 0.61 × 10[SUP]16[/SUP]cm (i.e., 0.002 pc) at 0.18 μm, and a most-likely index of ν = 0.4. The standard disc (ν = 4/3) model is not ruled out by our data, and is found within the 95% confidence interval associated with our measurements. We demonstrate that, for H1413+117, the existence of an extended continuum in addition to the disc emission only has a small impact on the inferred disc parameters, and is unlikely to solve the tension between the microlensing source size and standard disc sizes, as previously reported in the literature. Based on observations made with ESO Telescopes at the Paranal Observatory (Chile). ESO program ID: 386.B-0337.Appendices A and B are available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201526832/olm">http://www.aanda.org</A> [less ▲]

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See detailEvidence for very large-scale coherent orientations of quasar polarization vectors
Hutsemekers, Damien ULiege

in Astronomy and Astrophysics (1998), 332

On the basis of a new sample of quasar optical polarization measurements, we have found that, in a region of the sky, the quasar polarization vectors are not randomly oriented as naturally expected, but ... [more ▼]

On the basis of a new sample of quasar optical polarization measurements, we have found that, in a region of the sky, the quasar polarization vectors are not randomly oriented as naturally expected, but appear concentrated around one preferential direction. In order to verify this surprising although preliminary result, we have compiled a large sample of quasar polarization measurements from the literature. With quite severe criteria to eliminate at best the contamination by our Galaxy, a sample of 170 quasars with good quality polarization measurements has been defined. Maps in redshift slices reveal a few regions where the polarization vectors are apparently aligned. To handle the problem more quantitatively, non-parametric 3D statistical tests were designed, as well as a method for visualizing spatially the results. The significance is evaluated through Monte-Carlo simulations. Applied to our sample of 170 polarized quasars, two different statistical tests provide evidence, with significance levels of 0.005 and 0.015 respectively, that the optical polarization vectors of quasars are not randomly distributed over the sky but are coherently oriented on very large spatial scales. This orientation effect appears spatially delimited in the 3D Universe, mainly occuring in a few groups of 10-20 objects. The polarization vectors of objects located along the same line of sight but at different redshifts do not appear accordingly aligned. Essentially for this reason, instrumental bias and contamination by interstellar polarization in our Galaxy are unlikely to be responsible for the observed effect. The very large scale at which this local orientation effect is observed indicates the presence of correlations in objects or fields on spatial scales ~ 1000 h(-1) Mpc at redshifts z =~ 1-2, suggesting an effect of cosmological importance. Several possible and testable interpretations are discussed. Tables~2 and 3 are also available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/Abstract.html [less ▲]

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See detailEvidence for violent ejection of nebulae from massive stars
Hutsemekers, Damien ULiege

in Astronomy and Astrophysics (1994), 281(Letters), 81-84

We report the results of a systematic search for nebulae around Luminous Blue Variable LBVs) and the discovery of a strong correlation between the mass of the nebulae and the luminosity of the central ... [more ▼]

We report the results of a systematic search for nebulae around Luminous Blue Variable LBVs) and the discovery of a strong correlation between the mass of the nebulae and the luminosity of the central stars. This correlation holds for both the dust and ionized gas masses of the nebulae. The existence of a 'nebular mass-stellar luminosity' relation and the fact that not all LBVs are presently associated with a nebula give evidence against a continuous mass-loss mechanism for the formation of these nebulae. Further, the good agreement found between the observed relation and predictions by Maeder (1989), suggests that all these nebulae may be due to a violent ejection of matter caused by an instability of structural origin. [less ▲]

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See detailEvidence for vortex staircases in the whole angular range due to competing correlated pinning mechanisms
Silhanek, Alejandro ULiege; Civale, L.; Candia, S. et al

in Physical Review. B : Condensed Matter (1999), 59(21), 13620-13623

We present measurements of the angular dependence of the irreversible magnetization of YBa2Cu3O7 single crystals with columnar defects inclined with respect to the c axis. At high fields a sharp maximum ... [more ▼]

We present measurements of the angular dependence of the irreversible magnetization of YBa2Cu3O7 single crystals with columnar defects inclined with respect to the c axis. At high fields a sharp maximum centered at the tracks direction is observed. At low fields we identify a lock-in phase characterized by an angle-independent pinning strength and observe an angular shift of the peak towards the c axis that originates in the misalignment between vortices and applied field in anisotropic materials. The interplay among columnar defects, twins, and intrinsic pinning by the ab planes generates a variety of staircase structures. We show that correlated pinning dominates for all orientations of the applied field. [S0163-1829(99)09417-5]. [less ▲]

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See detailEvidence for wastewater influence in a low impacted area throughout stable isotope analyses of the limpet Patella caerulea and epilithic biofilms
Vermeulen, Simon ULiege; Lepoint, Gilles ULiege; Gobert, Sylvie ULiege

Poster (2009, January)

Eutrophication is considered to be one of the main threats to marine environments leading to changes in trophic status of ecosystems and alteration of biological diversity. Carbon and Nitrogen stable ... [more ▼]

Eutrophication is considered to be one of the main threats to marine environments leading to changes in trophic status of ecosystems and alteration of biological diversity. Carbon and Nitrogen stable isotopes analyses were performed on the limpet Patella caerulea and one of its food sources (epilithic biofilms) to assess their potential as early indicators of eutrophication. Samples were seasonally collected in 2005-2006 on five locations gradually exposed to urban sewage in the Calvi Bay and in the Marseilles harbour. Stable isotope signatures of Patella caerulea muscles exhibited steady site - specific values over seasons. In contrast to this time – integrated signal, wide variations in biofilm values show that either composition or isotopic ratios of food sources may vary greatly in time and space. Elevated δ15N values of limpets and biofilms, typical of wastewater influence but unrelated to nitrogen loads, indicate the biological availability of sewage-derived nitrogen in the Calvi Bay and the Marseilles harbour. A reference level of δ15N values is rapidly reached with increasing depth that indicates the limited vertical extent of pollution in the Calvi Bay. [less ▲]

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See detailEvidence for widespread endemism among Antarctic micro-organisms
Vyverman, Wim; Verleyen, Elie; Wilmotte, Annick ULiege et al

in Polar Science (2010), 4

Understanding the enormous diversity of microbes, their multiple roles in the functioning of ecosystems, and their response to large-scale environmental and climatic changes, are at the forefront of the ... [more ▼]

Understanding the enormous diversity of microbes, their multiple roles in the functioning of ecosystems, and their response to large-scale environmental and climatic changes, are at the forefront of the international research agenda. In Antarctica, where terrestrial and lacustrine environments are predominantly microbial realms, an active and growing community of microbial ecologists is probing this diversity and its role in ecosystem processes. In a broader context, this work has the potential to make a significant contribution to the long-standing debate as to whether microbes are fundamentally different from macroorganisms in their biogeography. According to the ubiquity hypothesis, microbial community composition is not constrained by dispersal limitation and is solely the result of species sorting along environmental gradients. However, recent work on several groups of microalgae is challenging this view. Global analyses using morphology-based diatom inventories have demonstrated that, in addition to environmental harshness, geographical isolation underlies the strong latitudinal gradients in local and regional diversity in the Southern hemisphere. Increasing evidence points to a strong regionalization of diatom floras in the Antarctic and sub- Antarctic regions, mirroring the biogeographical regions that have been recognized for macroorganisms. Likewise, the application of molecular-phylogenetic techniques to cultured and uncultured diversity revealed a high number of Antarctic endemics among cyanobacteria and green algae. Calibration of these phylogenies suggests that several clades have an ancient evolutionary history within the Antarctic continent, possibly dating back to 330 Ma. These findings are in line with the current view on the origin of Antarctic terrestrial metazoa, including springtails, chironomids and mites, with most evidence suggesting a long history of geographic isolation on a multi-million year, even pre-Gondwana break-up timescale [less ▲]

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See detailEvidence of a changing size-frequency distribution of landslides in the Kyrgyz Tien Shan, Central Asia
Schlögel, Romy; Torgoev; De Marneffe, Cédric et al

in Earth Surface Processes & Landforms (2011), 36/12

There is a strong possibility that environmental change (whether climate or land use) will be manifest as changes in the size–frequency distribution of landslides. Here, evidence is presented for this ... [more ▼]

There is a strong possibility that environmental change (whether climate or land use) will be manifest as changes in the size–frequency distribution of landslides. Here, evidence is presented for this from western Kyrgyzstan, Central Asia. Remote sensing and spatial analysis have been applied to map mass movements in the central part of the Maily‐Say Valley and to detect recent landslide activations. The evolution of landslide activity over the past 50 years has been analysed on the basis of pre‐existing landslide maps and new analyses of aerial photographs as well as Quickbird images. Five inventories were produced for the years 1962 (based on the existing map of 1962 and aerial photographs of 1962), 1984 (based on the existing map of 1977 and aerial photographs of 1984), 1996 (based on aerial photographs of 1996), 2002 (based on the existing map of 2003 and Quickbird imagery of 2002) and 2007 (based on Quickbird imagery of 2007). The geomorphologic features contained in the catalogues represent the landslide bodies observed from remote imagery of the corresponding year. Mapped landslides are generally considered as the result of a series of slope failure events. Size–frequency analyses applied to the five landslide inventories show that both the number and size of unstable slopes increased from 1962 (162 objects) to 2007 (208 objects) and the power‐law exponent decreased over time. This changing power‐law exponent may indicate that landslide‐related hazards are increasing. This tendency is documented in more detail for two active landslide zones, one in the main valley and one located to the west of it. Landslide detection methods were used to assist the evolution of slope instabilities. Choosing appropriate thresholds, the image subtraction method based on normalized difference vegetation index (NDVI) allowed accurate detection of new sliding activation in these two zones. This confirmed the results of the more extensive survey that there is a systematic shift in power law exponents and size–frequency distributions for Central Asian landslides. [less ▲]

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See detailEvidence of a complex phylogeographic structure in the common dormouse, Muscardinus avellanarius (Rodentia: Gliridae)
Mouton, Alice ULiege; Grill, Andrea; Sara, Maurizio et al

in Biological Journal of the Linnean Society (2012), 105(3), 648-664

This is the first mitochondrial phylogeography of the common dormouse, Muscardinus avellanarius (Linnaeus, 1758), a hibernating rodent strictly protected in Europe (Habitat Directive, annex IV; Bern ... [more ▼]

This is the first mitochondrial phylogeography of the common dormouse, Muscardinus avellanarius (Linnaeus, 1758), a hibernating rodent strictly protected in Europe (Habitat Directive, annex IV; Bern Convention, annex III). The 84 individuals of M. avellanarius, sampled throughout the distributional range of the species, have been sequenced at the mitochondrial DNA gene (cytochrome b, 704 base pairs). The results revealed two highly divergent lineages, with an ancient separation around 7.7 Mya and a genetic divergence of 7.7%. Lineage 1 occurs in Western Europe (France, Belgium, and Switzerland) and Italy, and lineage 2 occurs in Central–Northern Europe (Poland, Germany, Latvia, and Lithuania), on the Balkan Peninsula, and in Turkey. Furthermore, these two lineages are subdivided into five sublineages genetically isolated with a strong geographical association. Therefore, lineage 1 branches into two further sublineages (Western European and Italian), whereas lineage 2 contained three sublineages (Central–Northern European, Turkish, and Balkan). We observed low genetic diversity within the sublineages, in contrast to the significant level of genetic differentiation between them. The understanding of genetic population structure is essential for identifying units to be conserved. Therefore, these results may have important implications for M. avellanarius conservation. [less ▲]

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See detailEvidence of a fine-scale genetic structure for the endangered Pyrenean desman (Galemys pyrenaicus) in the French Pyrenees
Gillet, François ULiege; Cabria Garrido, Maria Teresa; Blanc, Frédéric et al

Poster (2015, August 05)

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See detailEvidence of a fine-scale genetic structure for the endangered Pyrenean desman (Galemys pyrenaicus) in the French Pyrenees
Gillet, François ULiege; Cabria Garrido, Maria Teresa; Blanc, Frédéric et al

Poster (2014, December)

The Pyrenean desman (Galemys pyrenaicus) is a small semi-aquatic mammal endemic to the Pyrenean Mountains and the northern half of the Iberian Peninsula where it lives in mountain streams of cold and well ... [more ▼]

The Pyrenean desman (Galemys pyrenaicus) is a small semi-aquatic mammal endemic to the Pyrenean Mountains and the northern half of the Iberian Peninsula where it lives in mountain streams of cold and well-oxygenated flowing waters (Nores et al. 2007). This species is currently considered as vulnerable in the IUCN Red List (Fernandes et al. 2008) and has been suffering from habitat loss and fragmentation for decades, inevitably impacting its distribution. The ecology and biology of this species are poorly known, notably because of its elusive behavior and its primarily nocturnal activity (Stone 1987, Bertrand 1994). Its distribution area is even not definitively established. Furthermore, a recent genetic study, based on mitochondrial and intronic sequences (Igea et al. 2013), showed that the genetic variability of the Pyrenean desman is very low in the Pyrenees. In this study we investigated the potential existence of a genetic structure and gene flow at a smaller scale using 24 polymorphic microsatellites loci. As the Pyrenean desman is a very elusive species, we completed our sample collection of tissues with faeces samples coming from the French distribution area of this species. Doing so, we successfully identify 70 individuals out of 355 faeces samples. Bayesian analyses revealed a cryptic genetic structure in our data set. Three clusters were evidenced (one western, one central and one eastern) and gene flow appears to be limited between these clusters (min. Fst value of 0.2). [less ▲]

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See detailEvidence of a fine-scale genetic structure for the endangered Pyrenean desman (Galemys pyrenaicus) in the French Pyrenees
Gillet, F; Cabria, M.; Blanc, F. et al

in Journal of Mammalogy (2017)

The Pyrenean desman (Galemys pyrenaicus) is a small, semi-aquatic mammal endemic to the Pyrenean Mountains and the northern half of the Iberian Peninsula where it lives in cold and well-oxygenated flowing ... [more ▼]

The Pyrenean desman (Galemys pyrenaicus) is a small, semi-aquatic mammal endemic to the Pyrenean Mountains and the northern half of the Iberian Peninsula where it lives in cold and well-oxygenated flowing mountain streams. This species is currently classified as vulnerable on the IUCN Red List and has been undergoing habitat loss and fragmentation for decades, inevitably impacting its distribution. A recent genetic study, based on mitochondrial and intronic sequences, showed that the genetic variability of the Pyrenean desman is very low in the Pyrenees. In this study, we investigated the potential existence of genetic structure and gene flow at a smaller scale using 24 polymorphic microsatellite loci. As the Pyrenean desman is a very elusive species, we supplemented our tissue sample collection with samples of feces collected in the French range of this species. We successfully identified 70 individuals based on 355 fecal samples. Bayesian analyses revealed 3 genetic and geographic clusters (1 eastern, 1 central, and 1 western, including 3 genetic sub-clusters), with origins tracing back only 200 years. These clusters were characterized by low levels of genetic diversity and high inbreeding coefficients. Although gene flow among clusters appeared to be limited, populations seem to have exchanged alleles recently. Therefore, connectivity between watersheds should be enhanced to maintain genetic diversity and potentially improve the long-term survival of the Pyrenean desman in France [less ▲]

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See detailEvidence of a highly complex phylogeographic structure on a specialist river bird species, the dipper (Cinclus cinclus).
Hourlay, F.; Libois, Roland ULiege; D'Amico, F. et al

in Molecular Phylogenetics & Evolution (2008), 49(2), 435-44

This study details the phylogeographic pattern of the white-throated dipper (Cinclus cinclus), a Palearctic, temperate, passerine bird that is exclusively associated with flowing water. Our results reveal ... [more ▼]

This study details the phylogeographic pattern of the white-throated dipper (Cinclus cinclus), a Palearctic, temperate, passerine bird that is exclusively associated with flowing water. Our results reveal a complex phylogeographic structure with at least five distinct lineages for the Western Palearctic region. As for many species of the Western Palearctic fauna and flora, this genetic structure is probably linked to the isolation of populations in different southern refuges during glacial periods. Furthermore, the isolation of populations in Scandinavia and/or Eastern regions, but also in Morocco and probably in Corsica, was accentuated by ecological and biogeographic barriers during Quaternary interglacial periods. During glacial periods, Italy, Sicily and the Balkano-Carpathian region acted as major refuge zones for the dipper. At the end of the last ice age, Western Europe was repopulated by dippers from an Italian refuge, while Eastern Europe was recolonised by Balkano-Carpathian birds. A large contact zone between these two lineages was evidenced and extends from Luxembourg to Hungary. Finally, our results indicate the need to clarify the taxonomic status of the dipper, especially concerning the European subspecies whose validity appears uncertain. [less ▲]

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See detailEvidence of a limited contribution of feto-maternal interactions to trophoblast differentiation along the invasive pathway
Goffin, Frédéric ULiege; Munaut, Carine ULiege; Malassine, A. et al

in Tissue Antigens (2003), 62(2), 104-116

Trophoblast differentiation is a key event in human placental development. During extravillous trophoblast (EVT) differentiation, stem cells from the anchoring villi detach from their basement membrane ... [more ▼]

Trophoblast differentiation is a key event in human placental development. During extravillous trophoblast (EVT) differentiation, stem cells from the anchoring villi detach from their basement membrane and proliferate to form aggregates called trophoblast cell columns (TCCs). They subsequently invade the decidua and differentiate into interstitial and endovascular trophoblasts. The influence of the decidua on EVT differentiation is controversial. We therefore compared the pattern of trophoblast differentiation marker expression in viable intrauterine and tubal pregnancies, as decidual cell markers (prolactin [PRL] and insulin-like growth factor binding Protein-1 [IGFBP1]) were only expressed in endometrial implantation sites. Extravillous trophoblast differentiation in anchoring villi from uterine and ectopic pregnancies exhibited a comparable phenotypical switch: alpha6 integrin subunit, E-cadherin, EGF receptor, Ki 67 and connexin 40 were localized in the proximal part of the TCC, while alpha5beta1 and alpha1 integrins, c-erb B2, hPL and HLA-G were expressed by invasive cytotrophoblasts. The cyclin-dependent kinase inhibitors p16 and p57 were mainly detected in invasive cytotrophoblasts some distance from the columns. However, the TCC was markedly longer in tubal pregnancy than in intrauterine pregnancy. These findings suggest that the decidua is not necessary to trigger EVT invasion, but that it is likely to limit the extent of the TCC and to accelerate the onset of EVT migration. [less ▲]

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