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See detailEtude de la taille des nanoparticules après incorporation dans des sphéroïdes gastrorésistants
Duvivier, F; Grandfils, Christian ULiege; Léonard, F et al

in Journal de Pharmacie de Belgique (1997), 52(3), 123

Nanoparticles can be used as an attractive carrier for the controlled delivery of drugs by the oral route. This nanoparticular delivery system can protect an active ingredient from enzymatic degradations ... [more ▼]

Nanoparticles can be used as an attractive carrier for the controlled delivery of drugs by the oral route. This nanoparticular delivery system can protect an active ingredient from enzymatic degradations and enhance its absorption from the intestinal mucosa. We studied the development of a gastroresistant dosage form for the oral administration of nanoparticles. Fast disintegrating pellets were used for the administration of nanoparticles and for their transit to the site of absorption. A gastroresistant film was applied onto the pellets to protect the nanoparticles and/ or the active substance from the acid gastric environment. The integrity of the nanoparticle size was assessed after two critical manufacturing steps: the extrusion/spheronisation process and the coating process. The determination of the nanoparticles size distribution was performed by photon correlation spectroscopy (PCS). The comparison of the PCS results between the original nanoparticles and the nanoparticles incorporated in the pellets shows a very low aggregation. Moreover the coating process was not a critical step since it was not responsible for an additional agglomeration of the nanoparticles. In conclusion, our manufacturing process allows the redispersion of the nanoparticles with a little change of the size distribution. In a next study we well try to quantify the release of the nanoparticles from the pellets. [less ▲]

Detailed reference viewed: 19 (1 ULiège)
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See detailÉtude de la taxocénose des Carabidae (Coleoptera) dans les écosystèmes agricoles du Brabant-Wallon.
Hance, Thierry; Grégoire-Wibo, Colette; Stassart, Pierre M ULiege et al

in Actes du Symposium sur les invertébrés de Belgique (1989)

Detailed reference viewed: 21 (1 ULiège)
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See detailEtude de la technique LIBS en vue du tri des vitrocéramiques dans les déchets verriers
Georges, Marc ULiege; Carapelle, Alain ULiege; Mombaerts, Johan et al

Conference (2008, November)

Detailed reference viewed: 55 (6 ULiège)
Peer Reviewed
See detailEtude de la texture des nodules océaniques en vue de leur utilisation comme catalyseurs
Dodet, Claude ULiege; Noville, Francis ULiege; Crine, Michel ULiege et al

in Revue Roumaine de Chimie (1984), 29

Detailed reference viewed: 11 (3 ULiège)
Peer Reviewed
See detailEtude de la texture des nodules océaniques par l'analyse des isothermes d'adsorption-désorption d'azote
Dodet, Claude ULiege; Noville, Francis ULiege; Crine, Michel ULiege et al

in Bulletin des Sociétés Chimiques Belges (1983), 92

Detailed reference viewed: 12 (3 ULiège)
Peer Reviewed
See detailÉtude de la texture poreuse d'un matériau polymère cellulaire utilisé en ingénierie tissulaire par microtomographie à rayons X
Lecocq, Raphaël; Toye, Dominique ULiege; Maquet, Véronique et al

Poster (2005, October)

Detailed reference viewed: 54 (5 ULiège)
Peer Reviewed
See detailEtude de la texture poreuse des nodules océaniques polymétalliques
Dodet, Claude ULiege; Noville, Francis ULiege; Crine, Michel ULiege et al

in Annales de Chimie Science des Materiaux (1983), 8

Detailed reference viewed: 21 (4 ULiège)
See detailEtude de la tolérance biologique de l'alimentation parentérale chez le nouveau né en dessous de 1500 g
Battisti, Oreste ULiege; Burrin, J.; Brown, M. et al

Conference (1981)

Detailed reference viewed: 21 (8 ULiège)
See detailEtude de la toxicite de cinq huiles essentielles extraites de Citrus sp. a l'egard de Sitophilus zeamais Prostephanus truncatus et Tribolium castaneum.
Haubruge, Eric ULiege; Gilson, J. C.; Gaspar, Charles ULiege et al

in Internationaal Symposium over Fytofarmacie en Fytiatrie (1989), 41

Detailed reference viewed: 93 (18 ULiège)
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See detailEtude de la transmission du gammaherpèsvirus murin 4: importance de la glycoprotéine gp150 et développement de stratégies antivirales basées sur l'utilisation du cidofovir
Zeippen, Caroline ULiege

Doctoral thesis (2017)

Gammaherpèsviruses are important pathogens in human medicine. Indeed, Epstein Barr virus and Kaposi Sarcoma associated herpesvirus are responsible for numerous lymphoproliferative diseases and cancers ... [more ▼]

Gammaherpèsviruses are important pathogens in human medicine. Indeed, Epstein Barr virus and Kaposi Sarcoma associated herpesvirus are responsible for numerous lymphoproliferative diseases and cancers. Murid Herpesvirus-4 (MuHV-4) is usually used as a model for human gammaherpèsviruses. Until now, the major limitation of this model was the absence of transmission in laboratory animals. Recently, a sexual transmission of MuHV-4 has been described in laboratory mice. This observation allows, on the one hand, to study mechanisms underlying natural transmission, such as cellular trospism, importance of viral proteins, or immunity response during this part of the cycle. On the other hand, this transmission model allows to test efficiency of measures to reduce transmission. Indeed, herpesvirus are archetype of persistant viruses as infection persists lifelong once established. Studying mechanisms underlying transmission and how to use these mechanisms to reduce it efficiently is therefore of primordial importance. In a first study, we focussed on the biological relevance of mechanisms described previously in vitro. Indeed, a MuHV-4 glycoprotein, gp150, has been shown to participate to the release of infectious particles from cells and to evasion of humoral immunity, two functions that could be important for the virus during transmission. Our results showed that gp150 is essential for an efficient sexual transmission of the MuHV-4. Indeed, gp150 promotes the release of infectious particles from infected vaginal epithelial cells. These results has been published in Journal of Virology in July 2017. In a second study, the same model was used to test efficiency of an antiviral molecule to reduce sexual transmission of the MuHV-4. A nucleotide analogue, the cidofovir, was administrated to mice according to different protocols. A daily administration of cidofovir reduced drastically genital shedding, but also prevent completely infection of naive mice after sexual contact. Finally, a single injection of cidofovir, administered 24 hours after sexual contact, reduced significantly transmission. Altogether, in this work, we used a transmission model of a gammaherpèsvirus in two differents studies: the first foccused on glycoprotein implicated during the transmission and established the importance of a single viral glycoprotein for an efficient transmission. The second study highlighted the efficiency of antiviral drugs to prevent infection by gammaherpesviruses. [less ▲]

Detailed reference viewed: 34 (3 ULiège)
See detailUne étude de la trisomie 21
Frenkel, Stéphanie ULiege

Conference given outside the academic context (2000)

Detailed reference viewed: 30 (9 ULiège)
See detailUne étude de la trisomie 21
Frenkel, Stéphanie ULiege

Conference given outside the academic context (2000)

Detailed reference viewed: 27 (4 ULiège)
Peer Reviewed
See detailEtude de la validité de la mesure réflectométrique des fumées
Rondia, D.; Albert, Adelin ULiege

in Ed. CNEPAC (1973)

Detailed reference viewed: 6 (1 ULiège)
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See detailEtude de la variabilité de la qualité de la viande de porc par analyse en composantes principales
Leroy, Bernadette ULiege; Etienne, Grégory; China, Bernard et al

in Sciences des Aliments (2008), 28(6), 451-468

Study of the variability of pork quality by Principal Component Analysis (PCA) Principal component analysis (PCA) was performed to study the relationships between technological, organoleptic ... [more ▼]

Study of the variability of pork quality by Principal Component Analysis (PCA) Principal component analysis (PCA) was performed to study the relationships between technological, organoleptic, microbiological and zootechnic variables, measured on 264 pigs belonging to different Belgian production systems. The four first principal components explained 63 % of the total variability. The variables such as the pH, the electrical conductivity, the brightness and the color of meat presented the best correlation with the first principal component whereas the variables such as the E. coli Count and the Total Viable Count measured on the carcass, the hot carcass weight and the cooking loss of meat presented the best correlation with the second principal component. The first principal component was defined as an axis of technological and organoleptic quality whereas the second was defined as a microbiological axis. PCA allowed to differentiate two groups in terms of technological and organoleptic properties. A group including samples belonged to the first quality production chain and a part of samples belonged to the second was separated from the principal group by a lower pH, measured 45 minutes post mortem, and a paler meat. [less ▲]

Detailed reference viewed: 115 (22 ULiège)
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See detailEtude de la variabilité de la qualité de la viande de porc par analyse en composantes principales
Leroy, Bernadette ULiege; Etienne, Grégory; China, bernard et al

in Viandes & Produits Carnés - Hors Série 10èmes Journées Sciences du Muscle et Technologie des Viandes (2004)

L’objectif de ce travail est d’étudier, dans les conditions réelles de production, la variabilité de la qualité technologique, organoleptique et microbiologique de la viande de porc et d’objectiver les ... [more ▼]

L’objectif de ce travail est d’étudier, dans les conditions réelles de production, la variabilité de la qualité technologique, organoleptique et microbiologique de la viande de porc et d’objectiver les relations qui peuvent exister entre les variables évaluées. L’analyse en composantes principales a permis de mettre en évidence des groupes de variables et de visualiser les relations qui peuvent exister entre ces variables. La première composante principale est corrélée aux variables relatives à la qualité technologique et organoleptique de la viande. Elle met en opposition le pH45 d’une part et les paramètres L*, b* et Cond45 d’autre part. La deuxième composante principale peut être considérée comme un axe de qualité microbiologique. L’analyse en composantes principales a également permis de mettre en évidence des groupes d’individus. A titre d’exemple, les génotypes halothane ont pu être différenciés sur ce type de représentation de la variabilité de la qualité de la viande. [less ▲]

Detailed reference viewed: 133 (7 ULiège)
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See detailEtude de la variabilité des aptitudes à la transformation laitière en Région wallonne basée sur l'utilisation de la spectrométrie infrarouge
Colinet, Frédéric ULiege; Troch, Thibault ULiege; Vanden Bossche, S. et al

in 18ième Carrefour des Productions animales : Nouvelles approches pour une optimisation de nos élevages laitiers (2013, February)

Detailed reference viewed: 49 (15 ULiège)