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See detailEffect of Calcitonin on Bone Mass and Fracture Rates
Reginster, Jean-Yves ULiege

in American Journal of Medicine (1991), 91(5B), 19-22

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See detailEffect of calving interval on the economic results of dairy farms based on their typology.
Dalcq, Anne-Catherine ULiege; Beckers, Yves ULiege; Wyzen, Benoit et al

Conference (2015, July 15)

The calving interval (CI) can influence the milk production (MP) and the economic results of a farm. This research aimed to highlight the most economically important CI, on the basis of the accounts of ... [more ▼]

The calving interval (CI) can influence the milk production (MP) and the economic results of a farm. This research aimed to highlight the most economically important CI, on the basis of the accounts of breeders. The data set contained 1,318 accounts spread between 2007 and 2012. Technical information such as mean CI of the herd, percent of cows with a CI of less than 380 d (m380), between 380 and 419 d (e380419), between 420 and 459 d (e420459) and more than 459 d (p459), mean MP of the herd; as well as typological information such as quantity of equivalent concentrate (CC), number of ares of grass (GR) and of corn silage (CS) per livestock unit (LU); and economic information such as mean gross margin per cow were available. The relation between CI and the gross margin showed that if a single economic optimum of CI cannot be determined, this optimum could depend on the typology of the farm. Therefore, 4 groups were created by using a multiple correspondence analysis, including quantity of equivalent CC, number of ares of GR and of CS per LU as variables. The first group was the most intensive one with a feeding based mostly on CC and CS; the second group was similar but less intensive. The third group was the most extensive with high GR consumption. The fourth group was characterized by a near absence of CS but more CC. Moreover, m380, e380420, e420459, p459 were transformed from quantitative to qualitative variables by using numerical classification. A qualitative variable CI profile was created as a summary of all these variables. In each group, MP was modeled using the different CI variables. The assumption behind this modeling was that for a typological profile, the breeder must have the highest MP to maximize the gross margin. These models showed that MP is maximized when p459 is lower than 26%, lower than 37%, above 27% for the group 1, 2, 3 respectively. For the group 4, the model with the variable CI profile suggested that the economic optimum of CI is intermediate. These results underlined that the economic optimum of CI is related to the typology of the considered farm. Studying individual data is a perspective to determine more precisely CI with the best economic results. [less ▲]

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See detailEffect of candesartan cilexetil and angiotensin-converting enzyme inhibitor therapy on treatment adherence in hypertension
Krzesinski, Jean-Marie ULiege; Lins, R.; Vandenhoven, G. et al

in Journal of Hypertension (2001), 19

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See detailEffect of carbohydrate composition in barley and oat cultivars on microbial ecophysiology and the proliferation of Salmonella enterica in an in vitro model of the porcine gastrointestinal tract
Pieper, Robert; Bindelle, Jérôme ULiege; Rossnagel, Brian et al

in Applied and Environmental Microbiology (2009), 75(22), 7000-7016

The influence of the carbohydrate (CHO) composition of cereal cultivars on microbial ecophysiology was studied using an in vitro model of the porcine gastrointestinal tract. Ten hull-less barley cultivars ... [more ▼]

The influence of the carbohydrate (CHO) composition of cereal cultivars on microbial ecophysiology was studied using an in vitro model of the porcine gastrointestinal tract. Ten hull-less barley cultivars, six barley cultivars with hulls, six oat cultivars, and six oat groats that differed in beta-glucan, nonstarch polysaccharide (NSP), and starch contents and starch type were hydrolyzed enzymatically and incubated for 72 h with pig feces. Fermentation kinetics were modeled, and microbial compositions and short-chain fatty acid (SCFA) profiles were analyzed using terminal restriction fragment length polymorphism and gas chromatography. Cluster analysis and canonical ordination revealed different effects on fermentation and microbial ecology depending on the type of CHO and cultivar. First, in cultivars of barley with hulls and oats, the cellulose and insoluble NSP contents (i) increased Ruminococcus flavefaciens-like and Clostridium xylanolyticum-like phylotypes, (ii) increased acetate production, and (iii) decreased fermentation activity. Second, in hull-less barley cultivars the beta-glucan, amylose, amylopectin, crude protein, and soluble NSP contents determined the microbial community composition and activity as follows: (i) the amylose contents of the hull-less barley varieties increased the butyrate production and the abundance of Clostridium butyricum-like phylotypes, (ii) the beta-glucan content determined the total amounts of SCFA, and (iii) the amylopectin and starch contents affected the abundance of Clostridium ramosum-like phylotypes, members of Clostridium cluster XIVa, and Bacteroides-like bacteria. Finally, the effect of CHO on proliferation of Salmonella enterica in the model was determined. Salmonella cell counts were not affected, but the relative proportion of Salmonella decreased with hull-less barley cultivars and increased with oat cultivars as revealed by quantitative PCR. Our results shed light on the complex interactions of cereal CHO with intestinal bacterial ecophysiology and the possible impact on host health. [less ▲]

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See detailEffect of carbon dioxide on exopolysaccharide production and survival of Bifidobacterium bifidum after freeze-drying
Nguyen, Huu Thanh ULiege; Frank, Delvigne

Scientific conference (2015, June 07)

Introduction: Bifidobacteria are particularly sensitive to oxygen [1], there are well-documented in studies on their protection against to oxygen toxicity in fermentation process. However the ... [more ▼]

Introduction: Bifidobacteria are particularly sensitive to oxygen [1], there are well-documented in studies on their protection against to oxygen toxicity in fermentation process. However the deoxygenation by inert gas (i.e., nitrogen, carbon dioxide and hydrogen) caused decreases in oxido-reduction potential and improved survival ability of B. bifidum after drying and in storage [2]. It is noted that carbon dioxide can not only maintain the anaerobic growth conditions of Bifidobacterium longum JBL05 but also enhance the cell concentrations and the exopolysaccharide (EPS) secretion [1]. Moreover, EPS was known as a factor in the B. bifidum protection in freeze-drying [3]. Objectives: The deoxygenation by inert gas (i.e., CO2 and N2) to reduce the redox potential in B. bifidum THT0101 culture aimed at (i) improving the survival of cells during freeze-drying and (ii) increasing the EPS secretion during the fermentation. Methods and Results: ?B. bifidum THT0101 were cultured in untreated, as controls, and in the modified using gas treatments prior to the onset of culture. After culturing and freeze-drying, the concentration of exopolysaccharide and the viability of B.bifidum THT0101 were evaluated. The results showed that the increase of viability (5.06-15.6 folds compared to controls) was associated with the duration of degassing by CO2. Besides, the CO2 treatments led to decreased redox potential. The concentration of exopolysaccharide increased related to the rate of used CO2 and B. bifidum THT 0101 survival. Conclusions: ?The rate of CO2 treatment in culture led to the increase of exopolysaccharide concentration and B.bifidum THT0101 survival. [less ▲]

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See detailEffect of carbon doping on the structure of amorphous GeTe phase change material
Ghezzi, G. E.; Raty, Jean-Yves ULiege; Maitrejean, S. et al

in Applied Physics Letters (2011), 99(15), 1519063-15190631519063

Carbon-doped GeTe is a promising material for use in phase change memories since the addition of C increases the stability of the amorphous phase. By combining x-ray total scattering experiments and ab ... [more ▼]

Carbon-doped GeTe is a promising material for use in phase change memories since the addition of C increases the stability of the amorphous phase. By combining x-ray total scattering experiments and ab initio molecular dynamics, we show that carbon deeply modifies the structure of the amorphous phase through long carbon chains and tetrahedral and triangular units centered on carbon. A clear signature of these units is the appearance of an additional interatomic distance, around 3.3 Aring in the measured pair distribution function. Besides, the first Ge-Ge and Ge-Te distances are almost not affected by doping. [less ▲]

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See detailEffect of cardiac resynchronization therapy on functional mitral regurgitation in heart failure.
Lancellotti, Patrizio ULiege; MELON, Pierre ULiege; SakalihasanN, Natzi ULiege et al

in American Journal of Cardiology (2004), 94(11), 1462-5

Cardiac resynchronization therapy (CRT) reduces functional mitral regurgitation (MR) at rest. This study assessed exercise-induced changes in MR in patients with heart failure who were helped by CRT. The ... [more ▼]

Cardiac resynchronization therapy (CRT) reduces functional mitral regurgitation (MR) at rest. This study assessed exercise-induced changes in MR in patients with heart failure who were helped by CRT. The determinants of these exercise-induced changes in MR were analyzed in asynchronous and resynchronized left ventricles. [less ▲]

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See detailEffect of carprofen treatment following experimentally induced Escherichia coli mastitis in primiparous cows.
Vangroenweghe, F.; Duchateau, L.; Boutet, Philippe ULiege et al

in Journal of Dairy Science (2005), 88(7), 2361-2376

Acute Escherichia coli mastitis is one of the major sources of economic loss in the dairy industry due to reduced milk production, treatment costs, discarded milk, and occasional fatal disease ... [more ▼]

Acute Escherichia coli mastitis is one of the major sources of economic loss in the dairy industry due to reduced milk production, treatment costs, discarded milk, and occasional fatal disease. Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used as adjunctive therapy to antibiotics. The objective of the current study was to evaluate the effect of carprofen treatment following infusion of Escherichia coli into the mammary glands of primiparous cows during the periparturient period. Severity of mastitis was scored based on the average milk production in the uninfected quarters on d +2 postinoculation and a clinical severity score. Carprofen was administered intravenously at 9 h postchallenge, when clinical signs of mastitis appeared. In previous work, efficacy of NSAIDs was mainly evaluated using clinical symptoms. In the present study, the effect of carprofen on innate immune response was also assessed by quantification of inflammatory mediators. All primiparous cows reacted as moderate responders throughout the experimental period. Primiparous cows were intramammarily inoculated with 1 x 10(4) cfu of E. coli P4:O32 in 2 left quarters. Analysis of blood and milk parameters, including IL-8, complement component C5a, lipopolysaccharide-binding protein (LBP), soluble CD14, prostaglandin E2, and thromboxane B2 was performed from d 0 to d +6 relative to intramammary inoculation. Rectal temperature in carprofen-treated animals was lower than in control animals at 3 and 6 h posttreatment. Treatment also restored the decreased reticulorumen motility that occurs during E. coli mastitis to preinfection levels faster than in control animals. Carprofen treatment resulted in an earlier normalization of the clinical severity score. Eicosanoid (prostaglandin E2 and thromboxane B2) production in milk tended to be inhibited by carprofen. No significant differences in the kinetic patterns of somatic cell count, IL-8, complement component C5a, LBP, and soluble CD14 were observed. In conclusion, carprofen treatment improved general clinical condition by effective antipyrexia and restoration of reticulorumen motility but did not significantly inhibit eicosanoid production. Carprofen treatment did not result in a significant decrease of chemotactic inflammatory mediators, IL-8 and C5a, and early innate immune molecules, sCD14 and LBP. Therefore, major modulatory effects from NSAID administration were not observed in this mastitis model, although a larger study might confirm some apparent trends obtained in the present results. [less ▲]

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See detailEffect of catechins and citrus flavonoids on invasion in vitro.
Bracke, M.; Vyncke, B.; Opdenakker, G. et al

in Clinical & Experimental Metastasis (1991), 9(1), 13-25

Catechins, a group of flavonoid molecules, inhibit invasion of mouse MO4 cells into embryonic chick heart fragments in vitro. The anti-invasive effects can be ranked as follows: (+)-catechin greater than ... [more ▼]

Catechins, a group of flavonoid molecules, inhibit invasion of mouse MO4 cells into embryonic chick heart fragments in vitro. The anti-invasive effects can be ranked as follows: (+)-catechin greater than (-)-epicatechin greater than 3-O-methyl-(+)-catechin greater than 3-O-palmitoyl-(+)-catechin. Most of the catechins are unstable in cell culture media, and their spontaneous rearrangement products tend to bind to extracellular matrix (ECM). Due to these interactions proteases such as tissue-type plasminogen activator (t-PA) are linked to the ECM glycoprotein laminin. This leads to a partial inactivation of the enzyme. Within the group of catechins we found a positive correlation between anti-invasive activity and linking of t-PA to laminin. Citrus flavonoids are also anti-invasive in vitro (tangeretin greater than nobiletin greater than hesperidin = naringin). However, these stable molecules show poor affinity for ECM, and do not link enzymes to laminin. These data suggest that catechins and citrus flavonoids inhibit invasion in vitro by different mechanisms. [less ▲]

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See detailThe effect of ceiling configurations on indoor air motion and ventilation flow rates
Nguyen, Anh Tuan ULiege; Reiter, Sigrid ULiege

in Building & Environment (2011), (46), 1211-1222

The purpose of this paper is to evaluate the effects of a building parameter, namely ceiling configuration, on indoor natural ventilation. The computational fluid dynamics (CFD) code Phoenics was used ... [more ▼]

The purpose of this paper is to evaluate the effects of a building parameter, namely ceiling configuration, on indoor natural ventilation. The computational fluid dynamics (CFD) code Phoenics was used with the RNG k-ɛ turbulence model to study wind motion and ventilation flow rates inside the building. All the CFD boundary conditions were described. The simulation results were first validated by wind tunnel experiment results in detail, and then used to compare rooms with various ceiling configurations in different cases. The simulation results generated matched the experimental results confirming the accuracy of the RNG k-ɛ turbulence model to successfully predict indoor wind motion for this study. Our main results reveal that ceiling configurations have certain effects on indoor airflow and ventilation flow rates although these effects are fairly minor. [less ▲]

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See detailEffect of celecoxib combined with thoracic epidural analgesia on pain after thoracotomy
Senard, Marc ULiege; Deflandre, Eric; Ledoux, Didier ULiege et al

in British Journal of Anaesthesia (2010), 105(2), 196-200

Detailed reference viewed: 41 (6 ULiège)
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See detailEffect of cell-cell and cell-matrix interactions on the response of fibroblasts to epidermal growth factor in vitro. Expression of collagen type I, collagenase, stromelysin and tissue inhibitor of metalloproteinases.
Colige, Alain ULiege; Lambert, Charles ULiege; Nusgens, Betty ULiege et al

in Biochemical Journal (1992), 285 ( Pt 1)

Investigations of the effect of epidermal growth factor (EGF) on the expression of four genes involved in the turnover of the extracellular matrix, collagen type I, collagenase, stromelysin and tissue ... [more ▼]

Investigations of the effect of epidermal growth factor (EGF) on the expression of four genes involved in the turnover of the extracellular matrix, collagen type I, collagenase, stromelysin and tissue inhibitor of metalloproteinases (TIMP) were performed on four strains of skin fibroblasts in vitro. Addition of EGF to subconfluent cultures for increasing periods of time up to 5 days induced an inhibition of procollagen alpha 1(I) mRNA and a strong stimulation of collagenase (100-fold) and stromelysin (1000-fold) mRNAs, whereas the mRNA of TIMP was increased to a lesser extent (5-fold). After a 40 h pulse with EGF, these effects persisted for 24-48 h after withdrawal of the growth factor and slowly diminished thereafter to attain control values after several days. By culturing fibroblasts for increasing periods of time, different levels of confluence were obtained allowing for the deposition of an extracellular biomatrix. The steady-state level of collagenase and stromelysin mRNAs were profoundly depressed in confluent as against non-confluent cultures, whereas no major change for TIMP and procollagen alpha 1(I) mRNAs was observed. Upon treatment of these cultures with EGF for 48h, the steady-state level of collagenase, stromelysin and TIMP increased, whereas procollagen alpha 1(I) mRNA was slightly reduced. These modifications were, at least in part, dependent upon a regulation of the transcription rate, as suggested from run-off experiments. Similar states of confluence were obtained by seeding cells at increasing densities in short-term cultures in which cell-cell contact predominated. In such culture conditions, the collagenase and stromelysin mRNAs were enhanced in high as compared to low density cultures. The response to EGF was progressively decreased for collagenase, stromelysin and, to a lesser extent, TIMP mRNAs at most densities and a complete lack of response to EGF at the highest cell density was observed. Under all culture conditions the modulation of collagenase mRNA was paralleled by similar modifications of enzyme activity. These results emphasize the importance of the cell-cell contacts and cell-matrix interactions in the expression of the genes coding for metalloproteinases or their inhibitor and their modulation by growth factors. [less ▲]

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See detailEffect of changing size and composition of a crop model ensemble on impact and adaptation response surfaces
Rodríguez, A.; Ferrise, R.; Ruiz-Ramos, M. et al

in Book of Abstracts - MACSUR2017 Scientific Conference (2017, May)

Detailed reference viewed: 7 (1 ULiège)
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See detailEffect of chitin on chitinase secretion by rodents
Frankignoul, M.; Jeuniaux, Charles ULiege

in Life Sciences (1965), 4

Detailed reference viewed: 7 (0 ULiège)
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See detailEffect of cholecalciferol recommended daily allowances on vitamin D status and fibroblast growth factor-23: an observational study in acute burn patients.
ROUSSEAU, Anne-Françoise ULiege; DAMAS, Pierre ULiege; LEDOUX, Didier ULiege et al

in Burns : Journal of the International Society for Burn Injuries (2014), 40(5), 865-70

Detailed reference viewed: 20 (6 ULiège)
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See detailEffect of Cholesterol and Fatty Acids on the Molecular Interactions of Fengycin with Stratum Corneum Mimicking Lipid Monolayers.
Eeman, Marc; Francius, G.; Dufrêne, Yves et al

in Langmuir : the ACS journal of surfaces and colloids (2009), 25

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See detailEffect of chondroitin sulfate on soluble biomarkers of osteoarthritis: a method to analyze and interpret the results from an open-label trial in unilateral knee osteoarthritis patients.
Moller, Ingrid; Gharbi, Myriam; Martinez Serrano, Helena et al

in BMC Musculoskeletal Disorders (2016), 17(1), 416

BACKGROUND: The aim of this study was to investigate the effects of chondroitin sulfate (CS) on the serum levels of Coll2-1 in patients with knee OA. METHODS: Seventy two patients with unilateral ... [more ▼]

BACKGROUND: The aim of this study was to investigate the effects of chondroitin sulfate (CS) on the serum levels of Coll2-1 in patients with knee OA. METHODS: Seventy two patients with unilateral symptomatic knee OA were involved in a post-authorization open-label study evaluating CS (800 mg/day). The primary outcome was the % relative change in serum Coll2-1 (sColl2-1). The secondary outcomes were the evaluation of pain (VAS) and function (Lequesne's Index). Responders and non-responders were classified according to OMERACT-OARSI recommendations. Finally, an original cut-off method was applied to categorize patients and interpret individual variations in serum levels of Coll2-1. RESULTS: Patients showed no difference in the sColl2-1 levels at baseline. When considering responders and non-responders from the ITT population, a significant difference was found for Coll2-1 at 3 months (p = 0.030) and 6 months (p = 0.038). A decrease in pain (VAS) and an improvement in function (LI) were recorded throughout the visits (p < 0.01). Considering an intra-batch cut-off of 21 %, CS decreased Coll2-1 serum levels between baseline and 1-month visit compared to the value of Coll2-1 before treatment (screening visit) which can be interpreted as a drastic reduction of the proportion of patients with an increase of Coll2-1 over 21 % (reduction from 13 to 3 %). It also consisted in a more important proportion of patients with a decrease in Coll2-1 (from 5 to 10 %). CONCLUSION: This study proposes a new approach for the analysis and the interpretation of the individual variation in biomarker levels and introduces the notion of metabolic responders. TRIAL REGISTRATION: ID ISRCTN63795830 . The trial was retrospectively registered on 2 October, 2015. [less ▲]

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See detailEffect of chondroitin sulfate on soluble biomarkers of osteoarthritis: how to analyze and interpret the results from an open-label trial in unilateral knee osteoarthritis patients
Möller, I; Gharbi, Myriam; Martinez, H et al

in Annals of the Rheumatic Diseases (2016, June), 75(Suppl 2), 1167

Detailed reference viewed: 10 (5 ULiège)