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See detail« Différenciation sémiologique entre les troubles de l'attention avec ou sans hyperactivité et la bipolarité dans la petite enfance »
Scholl, Jean-Marc ULiege

Conference (2010, February 05)

Différenciation sémiologique entre les troubles de l'attention avec ou sans hyperactivité et la bipolarité dans la petite enfance. Le diagnostic de bipolarité reste peu connu des pédopsychiatres. Après ... [more ▼]

Différenciation sémiologique entre les troubles de l'attention avec ou sans hyperactivité et la bipolarité dans la petite enfance. Le diagnostic de bipolarité reste peu connu des pédopsychiatres. Après les premiers symptômes il faut en moyenne 10 ans et 3 à 5 médecins avant qu'un diagnostic correct ne soit posé. Notre étude, se rapportant à 170 enfants de 18 mois à 10 ans, met en évidence une sémiologie nuancée qui permet un diagnostic rapide et précoce d'un "tempérament maniaque bipolaire" comportant sept axes sémiologiques : 1. une forme "super-énergétique", 2. la clinique du sommeil, 3. un "mal-être en situation d'être seul", 4. des couleurs affectives expressives, 5. une tendance à l'excitabilité-désinhibition-appétence, 6. la prépondérance de l'attention divergente sur l'attention convergente, 7. la tendance à l'hyperactivité. Nous évoquons pour ces sept axes leur évolution développementale jusqu'à la vie adulte. La mise en évidence d'une clinique du "mal-être en situation d'être seul" est l'élément le plus original de notre recherche, il correspond à un déficit de la capacité à demeurer seul avec soi-même au calme. Ce mal-être est à distinguer de l'angoisse de séparation, même s'il peut y avoir un continuum ; il n'est pas pathognomonique de la bipolarité mais semble en faire systématiquement partie. Dans l'ADHD (déficit d'attention avec ou sans hyperactivité) on ne retrouve que les points 1, 6 et 7, par contre les points 2, 3, 4, 5 sont spécifiques de la bipolarité. Nous proposons 4 sous-groupes sémiologiques des états bipolaires et unipolaire dans l'enfance. Différentes comorbidités possibles pourront s'ajouter, ce qui apportera d'autres accentuations cliniques. Selon le temps imparti, nous pouvons également évoquer : des métaphores explicatives et thérapeutiques ; des réflexions neurophysiologiques jointes à cette sémiologie; le pronostic qui peut radicalement changer avec une prise en charge précoce. [less ▲]

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See detailDifférenciations sociospatiales et gouvernance municipale dans les banlieues de Beyrouth : à travers l'exemple de Sahel AlMatn AlJanoubi et des municipalités de Chiyah, Ghobeiri et Furn AlChebbak
Farah, Jihad ULiege

Doctoral thesis (2011)

La thèse s’inscrit dans le débat sur une des “grandes questions urbaines contemporaines”: comment dans la multiplication des projets individuels et collectifs de plus en plus fragmentés se construit la ... [more ▼]

La thèse s’inscrit dans le débat sur une des “grandes questions urbaines contemporaines”: comment dans la multiplication des projets individuels et collectifs de plus en plus fragmentés se construit la ville d’aujourd’hui? Dans un contexte d’étalement urbain continu et de crise des “grands récits” de la modernité, l’individu comme le groupe connaît de plus en plus de difficultés à trouver sa place, son “lieu”, en ville. La recherche de l’entre-soi et l’altérité devient de plus en plus importante dans cette quête. La thèse revient sur les différents concepts traitant des différenciations sociospatiales en ville (ségrégation, marginalisation, relégation, fragmentation). Elle remarque que ces concepts favorisent une lecture systémique de la réalité urbaine où les éléments factoriels économiques, culturels et politiques ont un rôle central dans l’explication. Tout en se mettant dans la continuité de ces travaux, la thèse privilégie une lecture se basant sur trois entrées: - La crise de citoyenneté urbaine (crise de définitions de la ville, de ses limites, de ses citoyens, de leurs droits et surtout de sa gouvernance) comme principale grille explicative - Le local. Ce dernier étant d’une part l’échelle où ces différenciations sociospatiales sont les plus manifestes, et d’autre part car c’est à cette échelle que les phénomènes systémiques doivent se “redéfinir” en s’inscrivant dans le contexte. - Les périphéries et les banlieues où la cirse de citoyenneté est plus nette et où les acteurs locaux – dans un milieu à la recherche de sens, et en continuelle redéfinition – cherchent à avoir plus d’emprise sur leur milieu direct. Dans ce contexte la thèse avance que les spécificités du local, notamment la gouvernance locale et la spécialisation économique ont un poids déterminant dans la définition des dynamiques territoriales et par suite des différenciations sociospatiales. Cette hypothèse est déclinée en deux hypothèses opérationnelles: 1. - L’une s’inscrivant dans une perspective historique: Si incontestablement des dynamiques induites de la globalisation affectent les différenciations sociospatiales dans l’espace beyrouthin, nous pensons que l’héritage d’un temps long dans ses dimensions politiques et économiques pèse encore fortement sur ces différenciations dans les banlieues de Beyrouth. 2. L’autre dans une perspective politique: La stabilisation du régime municipal est aujourd’hui la rationalité qui domine l’action municipale. Elle est déterminante de la gouvernance locale dans chaque commune et par suite consubstantielle de l’évolution des différenciations sociospatiales dans ces banlieues. Les banlieues de Beyrouth, considérées comme cas révélateur, sont retenues pour comme terrain d’étude Deux méthodes d’analyse complémentaires sont mobilisées. L’une dite diachronique essaie de repérer les constantes et les variables dans l’histoire d’un district de ces banlieues comprenant les actuelles banlieues sud et sud-est, en insistant sur les rôles particuliers de la gouvernance et de l’économie. L’autre dite synchronique tente de souligner des liens entre des typologies de gouvernance urbaine différentes et leurs impacts en termes de différenciations sociospatiales en mobilisant le concept de régimes urbains. Les principales conclusions sont: - Des arrière-pays consolidés, avant l’étalement des villes centres, ayant leurs propres dynamiques: leur urbanisation, leurs économies et leurs gouvernances locale, leurs trajectoires propres connaissent très tôt la fragmentation urbaine (conclusion en porte-à-faux par rapport au corpus de la fragmentation soulignant le rôle fondateur de la globalisation) - L’architecture du régime urbain local et sa recherche de stabilité interne affectent fortement l’articulation de l’échelle d’action locale aux échelles d’action supérieures. Comme elles affectent certaines formes de dynamiques territoriales locales (notamment celles inscrites dans le registre de construction identitaire des territoires). Toutefois elles semblent avoir moins d’impact sur les aspects centralités et flux des dynamiques territoriales. - La fragmentation politique du territoire peut s’avérer une ressource importante pour les acteurs locaux pour négocier et s’approprier une place, un “lieu” dans les agglomérations urbaines d’aujourd’hui. D’autre part, devant la pression continue que connaissent les territoires urbains des périphéries pour se redéfinir et s’articuler à de nouvelles entités sociospatiales en formation, on peut observer dans certains cas de la véritable innovation en termes de politiques urbaines. Ces municipalités peuvent représenter, comme dans le cas de certaines dans les banlieues de Beyrouth, des laboratoires qui font émerger des nouveaux outils urbains qui pourront servir pour penser et gérer la ville à d’autres échelles. [less ▲]

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See detailDifférencier l'enseignement : Pourquoi, comment ? Un exemple: la lettre
Moreau, Marie-Louise; Mouvet, Bernadette ULiege

in Enjeux : Revue de Formation Continuée et de Didactique du Français (1990), 19

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See detailDifferent activation signals induce distinct mast cell degranulation strategies.
Gaudenzio, Nicolas; Sibilano, Riccardo; Marichal, Thomas ULiege et al

in Journal of Clinical Investigation (2016), 126(10), 3981-3998

Mast cells (MCs) influence intercellular communication during inflammation by secreting cytoplasmic granules that contain diverse mediators. Here, we have demonstrated that MCs decode different activation ... [more ▼]

Mast cells (MCs) influence intercellular communication during inflammation by secreting cytoplasmic granules that contain diverse mediators. Here, we have demonstrated that MCs decode different activation stimuli into spatially and temporally distinct patterns of granule secretion. Certain signals, including substance P, the complement anaphylatoxins C3a and C5a, and endothelin 1, induced human MCs rapidly to secrete small and relatively spherical granule structures, a pattern consistent with the secretion of individual granules. Conversely, activating MCs with anti-IgE increased the time partition between signaling and secretion, which was associated with a period of sustained elevation of intracellular calcium and formation of larger and more heterogeneously shaped granule structures that underwent prolonged exteriorization. Pharmacological inhibition of IKK-beta during IgE-dependent stimulation strongly reduced the time partition between signaling and secretion, inhibited SNAP23/STX4 complex formation, and switched the degranulation pattern into one that resembled degranulation induced by substance P. IgE-dependent and substance P-dependent activation in vivo also induced different patterns of mouse MC degranulation that were associated with distinct local and systemic pathophysiological responses. These findings show that cytoplasmic granule secretion from MCs that occurs in response to different activating stimuli can exhibit distinct dynamics and features that are associated with distinct patterns of MC-dependent inflammation. [less ▲]

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See detailDifferent activities of chemokines CXCL12 and vCCL2 and peptides derived from their N-terminus towards the receptors CXCR7/ACKR3 and CXCR4
Szpakowska, Martyna ULiege; Gauthier, Pierre-Arnaud; Derj, Anouar et al

Poster (2014, November)

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See detailDifferent and synergistic effect of 5-Azacytidine and Rapamycin on ex vivo expansion of natural human T Regulatory cells
Conteduca, Giuseppina ULiege

Poster (2016, October 14)

Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are ... [more ▼]

Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are immunosuppressive drugs that promote selectively the expansion of CD4+CD25highFoxp3+ regulatory T cells.: We investigated whether 5-azaC and RAPA could be used together to promote the ex vivo expansion of Tregs purified from adult human peripheral blood.We found that 5-azaC helped maintain FOXP3 expression during the expansion process probably by promoting the conversion of T conventional (Tconv) in Treg, instead Rapa induces selectively apoptosis in Tconv cells and expansion in Treg. Addition of 5-azaC to RAPA treated cultures improved gene expression of FOXP3, CD25, STAT5 and TGF-B resulted in enhanced Treg expansion and suppressive activity. Also Rapa and 5-AzaC combination sustain Bcl-2 protein expression in Treg conferring resistance to apoptosis process. 5-azaC may have utility in ex vivo expansion of human Tregs, not as a single agent, but in combination with RAPA. These data may considerably accelerate the development of immunotherapeutic approaches for the treatment of autoimmune disease or posttransplant alloreactions by the adoptive transfer of nTreg cells [less ▲]

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See detailDifferent and synergistic effect of 5-Azacytidine and Rapamycin on ex vivo expansion of natural human T Regulatory cells
Conteduca, Giuseppina ULiege

Poster (2016, November 16)

Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are ... [more ▼]

Natural T regulatory cells (Treg) are challenging to expand ex vivo, and this has severely hindered in vivo evaluation of their therapeutic potential. 5-Azacytidine (5-azaC) and Rapamycin (RAPA) are immunosuppressive drugs that promote selectively the expansion of CD4+CD25highFoxp3+ regulatory T cells. We investigated whether 5-azaC and RAPA could be used together to promote the ex vivo expansion of Tregs purified from adult human peripheral blood. : We found that 5-azaC helped maintain FOXP3 expression during the expansion process probably by promoting the conversion of T conventional (Tconv) in Treg, instead Rapa induces selectively apoptosis in Tconv cells and expansion in Treg. Addition of 5-azaC to RAPA treated cultures improved gene expression of FOXP3, CD25, STAT5 and TGF-B resulted in enhanced Treg expansion and suppressive activity. Also Rapa and 5-AzaC combination sustain Bcl-2 protein expression in Treg conferring resistance to apoptosis process. 5-azaC may have utility in ex vivo expansion of human Tregs, not as a single agent, but in combination with RAPA. These data may considerably accelerate the development of immunotherapeutic approaches for the treatment of autoimmune disease or posttransplant alloreactions by the adoptive transfer of nTreg cells. [less ▲]

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See detailDifferent approaches for the simulation of an experimental building hosting a climate chamber devote to artificial fog production
Andre, Philippe ULiege; Kelly, N.; Boreux, Jean-Jacques ULiege et al

(2003, August)

In the context of a european project dealing with the issue of transport safety improvement in fog conditions, an experimental building has been constructed on the FUL campus, in the southern part of ... [more ▼]

In the context of a european project dealing with the issue of transport safety improvement in fog conditions, an experimental building has been constructed on the FUL campus, in the southern part of Belgium. This building hosts a climatic chamber in which a given indoor climate is to be maintained (temperature and relative humidity) whatever the external climate, in order to promote the artifical production of fog by water droplets spraying. During the design of the building and of the HVAC plant, different simulation approaches were carried out in order to evaluate and possibly optimize the technical choices concerning: - the building envelope - the material for the climatic chamber - the control strategy of the HVAC system Two categories of simulation tools were used to solve the different tasks: - building simulation tools - CFD programs For the first category, simulations were performed using both ESP-r and TRNSYS with the objective of solving the following questions: optimization of the building envelope (orientation and shading of the building, insulation, fenestration); sizing of the HVAC system; comparison of control strategies (direct control, indirect control, radiative and/or convective conditioning); estimation of energy consumption and comfort Within the second category, the FLUENT and ESP-r software were used and compared in order to predict the homogeneity of the thermal state within the test room and to calculate the effect of injecting a high amount of small water droplets on fog production, maintenance and visibility. Therefore, the ESP-r CFD module program was augmented with a specific model of water droplet diffusion. The paper will tackle the main modelling assumptions at the basis of each simulation experiment, the data preparation and the results of the calculations. For each phase, advantages and limitations of the simulation approach will be highlighted. These developments are considered as a first step towards the implementation of a virtual testing environment in the field of automotive transport which could be complemented by additional issues dealing with passengers comfort, acoustics, air quality, level of illuminance generated by the virtual production of fog. [less ▲]

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See detailDifferent approaches to measure environmental odours emitted by landfill areas
Romain, Anne-Claude ULiege; Delva, Julien ULiege; Nicolas, Jacques ULiege

Conference (2007)

This paper presents different methods to assess the odour emission and the odour annoyance in the surroundings. It is shown, on the example of landfill areas and composting facilities, that chemical ... [more ▼]

This paper presents different methods to assess the odour emission and the odour annoyance in the surroundings. It is shown, on the example of landfill areas and composting facilities, that chemical analyses are helpful to identify key compounds of the odour release, and to set up the specification of a monitoring instrument. Sensitive methods, like dynamic olfactometry or sniffing team investigation, are mainly applicable to provide a global odour plume or an average annoyance zone. And the electronic nose can supply a warning signal to the plant manager or a real time estimation of the annoyance zone. [less ▲]

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See detailDifferent beliefs about pain perception in the vegetative and minimally conscious states: a European survey of medical and paramedical professionals.
Demertzi, Athina ULiege; Schnakers, Caroline ULiege; Ledoux, Didier ULiege et al

in Progress in Brain Research (2009), 177

Pain management in severely brain-damaged patients constitutes a clinical and ethical stake. At the bedside, assessing the presence of pain and suffering is challenging due to both patients' physical ... [more ▼]

Pain management in severely brain-damaged patients constitutes a clinical and ethical stake. At the bedside, assessing the presence of pain and suffering is challenging due to both patients' physical condition and inherent limitations of clinical assessment. Neuroimaging studies support the existence of distinct cerebral responses to noxious stimulation in brain death, vegetative state, and minimally conscious state. We here provide results from a European survey on 2059 medical and paramedical professionals' beliefs on possible pain perception in patients with disorders of consciousness. To the question "Do you think that patients in a vegetative state can feel pain?," 68% of the interviewed paramedical caregivers (n=538) and 56% of medical doctors (n=1166) answered "yes" (no data on exact profession in 17% of total sample). Logistic regression analysis showed that paramedical professionals, religious caregivers, and older caregivers reported more often that vegetative patients may experience pain. Following professional background, religion was the highest predictor of caregivers' opinion: 64% of religious (n=1009; 850 Christians) versus 52% of nonreligious respondents (n=830) answered positively (missing data on religion in 11% of total sample). To the question "Do you think that patients in a minimally conscious state can feel pain?" nearly all interviewed caregivers answered "yes" (96% of the medical doctors and 97% of the paramedical caregivers). Women and religious caregivers reported more often that minimally conscious patients may experience pain. These results are discussed in terms of existing definitions of pain and suffering, the remaining uncertainty on the clinical assessment of pain as a subjective first-person experience and recent functional neuroimaging findings on nociceptive processing in disorders of consciousness. In our view, more research is needed to increase our understanding of residual sensation in vegetative and minimally conscious patients and to propose evidence-based medical guidelines for the management of possible pain perception and suffering in these vulnerable patient populations. [less ▲]

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See detailDifferent concepts of animal welfare and stakeholders arguments
Bartiaux-Thill, Nicole; Stassart, Pierre M ULiege; Lamine, Claire et al

Poster (2008, September 11)

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See detailDifferent contribution of chemokine N-terminal features attest a different ligand binding mode and a bias towards activation of the atypical chemokine receptor ACKR3/CXCR7 compared to CXCR4 and CXCR3
szpakowska, Martyna; Nevins, Amanda M; Meyrath, Max et al

in British Journal of Pharmacology (in press)

Background and purpose Chemokines and their receptors form an intricate interaction and signaling network that plays critical roles in various physiological and pathological cellular processes. The high ... [more ▼]

Background and purpose Chemokines and their receptors form an intricate interaction and signaling network that plays critical roles in various physiological and pathological cellular processes. The high promiscuity and apparent redundancy of this network makes probing individual chemokine/receptor interactions and functional effects, as well as targeting individual receptor axes for therapeutic applications, challenging. Despite poor sequence identity, the N-terminal regions of chemokines, which play a key role in their activity and selectivity, harbor several conserved features. Thus far, little is known regarding the molecular basis of their interactions with conventional vs. atypical chemokine receptors or the conservation of their contributions across chemokine-receptor pairs. Experimental Approach In this study, using a broad panel of chemokine variants and modified peptides derived from the N-terminal region of chemokines CXCL12, CXCL11, and vCCL2, we compare the role of various features in binding and activation of their shared receptors, the two canonical G protein-signaling receptors, CXCR4 and CXCR3, as well as the atypical scavenger receptor CXCR7/ACKR3, which shows exclusively arrestin-dependent activity. Key Results We provide exhaustive molecular insights into the plasticity of the ligand-binding pockets of these receptors, their chemokine binding modes, and their activation mechanisms. We show that, although the chemokine N-terminal region is a critical determinant, neither the most proximal residues nor the N-loop are essential for ACKR3 binding and activation, as opposed to CXCR4 and CXCR3. Conclusion and Implications These results suggest a different interaction mechanism between this atypical receptor and its ligands and illustrates its strong propensity to activation. [less ▲]

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See detailThe different contributions of cortical and trabecular bone to implant anchorage in a human vertebra
Ruffoni, Davide ULiege; Wirth, Andreas J.; Steiner, Juri A. et al

in BONE (2012), 50(3), 733-738

The quality of the pen-implant bone and the strength of the bone-implant interface are important factors for implant anchorage. With regard to pen-implant bone, cortical and trabecular compartments both ... [more ▼]

The quality of the pen-implant bone and the strength of the bone-implant interface are important factors for implant anchorage. With regard to pen-implant bone, cortical and trabecular compartments both contribute to the load transfer from the implant to the surrounding bone but their relative roles have yet to be investigated in detail. However, this knowledge is crucial for the better understanding of implant failure and for the development of new implants. This is especially true for osteoporotic bone, which is characterized by a deterioration of the trabecular architecture and a thinning of the cortical shell, leading to a higher probability of implant loosening. The aim of this study was to investigate the relative biomechanical roles of cortical and trabecular bone on implant pull-out stiffness in human vertebrae. The starting point of our investigation was a micro-computed tomography scan of an adult human vertebra. The cortical shell was identified and an implant was digitally inserted into the vertebral body. Pull-out tests were simulated with micro-finite element analysis and the apparent stiffness of the system with various degrees of shell thickness and bone volume fraction was computed. Our computational models demonstrated that cortical bone, although being very thin, plays a major role in the mechanical competence of the bone-implant construct. (C) 2011 Elsevier Inc. All rights reserved. [less ▲]

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See detailDifferent durations of grazing period for grazing fattening bulls
Dufrasne, Isabelle ULiege; Limbourg, Pierre; Gauthier, Sabine et al

in Proceeding of the 16th General Meeting of the European Grassland federation (1996)

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See detailDifferent environmental influences on etiology of atopic diseases in European populations as a basis for study of geneenvironment interactions.
Gusareva, Elena ULiege; Belozorov, Aleksey; Havelková, Helena et al

in Torres, S. L.; Marin, M. S. (Eds.) Genetic Predisposition to Disease (2008)

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. Sensitization to various airborne and food allergens contributes to different types of atopic ... [more ▼]

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens. Sensitization to various airborne and food allergens contributes to different types of atopic diseases, including asthma, eczema, and allergic rhinitis. The development of these diseases is influenced by both genetic and environmental factors. Several loci and genes that control IgE level have been described in different chromosomal regions. Some of them have been detected in several populations, others only in one or a few populations. These differences might be caused by variations of genetic composition between populations, different lifestyles and/or by environmental variations in major allergens triggering development of atopic diseases. Thus, the environmental conditions may likely determine, which from the potential atopy-controlling genes will operate in a certain population. As the first step in study of such gene-environment interactions we analyzed the specificity and intensity of sensitization to 40 different allergens in atopic patients from the Czech Republic and Ukraine, representing two genetically not very distant populations, which live in different environmental conditions. The atopic patients from both countries displayed a higher reactivity to inhalant than to food allergens. We found highly significant differences in sensitization to airborne allergens between patients from the two countries. The most pronounced allergens for the atopic patients from Ukraine were allergens from dust mites Dermatophagoides pteronyssinus (38.5%), Dermatophagoides farinae (48.1%) and cat (44.2%). In the atopic patients from the Czech Republic the level of sensitization to these allergens was similar, but the level of sensitization to outdoor allergens, grasses and trees was dramatically higher. More than 68% of the patients from the Czech Republic in comparison with less than 25% of the patients from Ukraine have been sensitized to cocksfoot, sweet vernal grass, timothy grass and cultivated rye (Bonferroni-corrected P values ranged from 0.0007 to 0.000000003). More than 50% and 60% of the patients from the Czech Republic but only 2% and 19.2% of the patients from Ukraine reacted to alder (corrected P < 0.00009) and birch (corrected P < 0.002), respectively. The higher sensitization to plant allergens of the patients from the Czech Republic was present in those with asthma and rhinitis, but not with dermatitis. The higher sensitization levels to outdoor allergens in the Czech Republic suggest an influence of westernization on development of allergic reactivity. Genetic analysis of atopic patients from these two countries will establish which geneloci control development of atopy under different environmental conditions. [less ▲]

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See detailDifferent estimations of heritabilities in dependence of major gene effects (Brief Report)
Buske, Bernd ULiege; Gengler, Nicolas ULiege

in Archiv Tierzucht / Archives Animal Breeding (2010), 53(6), 732-734

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See detailDifferent frameworks for Cobham's theorem in R
Leroy, Julien ULiege

Conference (2014, January)

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See detailDifferent glucosamine sulfate products generate different outcomes on osteoarthritis symptoms
Reginster, Jean-Yves ULiege; Bruyère, Olivier ULiege; Cooper, Cyrus

in Annals of the Rheumatic Diseases (2017), (Online First),

Detailed reference viewed: 28 (6 ULiège)