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See detailThe 1.5-angstrom structure of Chryseobacterium meningosepticum zinc beta-lactamase in complex with the inhibitor, D-captopril
Garcia-Saez, I.; Hopkins, J.; Papamicael, C. et al

in Journal of Biological Chemistry (2003), 278(26), 23868-23873

The crystal structure of the class-B beta-lactamase, BlaB, from the pathogenic bacterium, Chryseobacterium meningosepticum, in complex with the inhibitor, D-captopril, has been solved at 1.5-Angstrom ... [more ▼]

The crystal structure of the class-B beta-lactamase, BlaB, from the pathogenic bacterium, Chryseobacterium meningosepticum, in complex with the inhibitor, D-captopril, has been solved at 1.5-Angstrom resolution. The enzyme has the typical alphabeta/betaalpha metallo-beta-lactamase fold and the characteristic two metal binding sites of members of the subclass B1, in which two Zn2+ ions were identified. D-Captopril, a diastereoisomer of the commercial drug, captopril, acts as an inhibitor by displacing the catalytic hydroxyl ion required for antibiotic hydrolysis and intercalating its sulfhydryl group between the two Zn2+ ions. Interestingly, D-captopril is located on one side of the active site cleft. The x-ray structure of the complex of the closely related enzyme, IMP-1, with a mercaptocarboxylate inhibitor, which also contains a sulfhydryl group bound to the two Zn2+ ions, shows the ligand to be located on the opposite side of the active site cleft. A molecule generated by fusion of these two inhibitors would cover the entire cleft, suggesting an interesting approach to the design of highly specific inhibitors. [less ▲]

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See detailLes 10 ans d’Envol à l’école Saint-Pierre : La musique et le conte au centre des apprentissages et du vivre ensemble dans les classes
Gavray, Claire ULiege

Conference (2016, October 27)

historique du projet, évaluation des apports et perspectives

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See detail10 ans d'ORBI à L'ULiège
Pochet, Bernard ULiege

in Bulletin des Bibliothèques de France (2019)

This article is a report of the event organized to mark the tenth anniversary of the ORBi institutional repository at the University of Liège.

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See detail10 ans de l'"Erasmus Militaire"
Paile, Sylvain ULiege; Heng, Stéphanie

Article for general public (2018)

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See detail10 ans du Réseau de médecins vigies. L'enregistrement de la morbidité en Belgique
Comité de rédaction IHE SSMG; Gosset, Christiane ULiege

Report (1991)

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See detail10 bonnes raisons d’avoir un ENMG faussement pathologique
WANG, François-Charles ULiege

Conference (2008)

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See detail10 bonnes raisons d’avoir un ENMG normal
WANG, François-Charles ULiege

Conference (2006)

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See detail10 bonnes raisons de recommencer un ENMG
WANG, François-Charles ULiege

Conference (2007)

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See detailLes 10 étapes d’un Purchase Price Allocation, un exercice pas seulement réservé aux comptes consolidés des groupes cotés
Streel, Alexandre ULiege; Meunier, Virginie; Peffer, Jacques et al

in Ace Magazine et Archives Online: Fiscalité, Comptabilité, Audit, Droit des Affaires au Luxembourg (2017), 2017/7

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See detailLes 10 étapes d’un Purchase Price Allocation, un exercice pas seulement réservé aux groupes cotés
Streel, Alexandre ULiege; Pelzer, Christophe; Meunier, Virginie

in Revue Générale de Fiscalité et de Comptabilité Pratique (2017), 2017/5

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See detail10 façons d’interpréter une neuropathie asymétrique
WANG, François-Charles ULiege

Conference (2011)

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See detail10 façons d’interpréter une PNP axonale chronique
WANG, François-Charles ULiege

Conference (2009)

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See detail10 façons de distinguer une neuropathie d'une neuronopathie
WANG, François-Charles ULiege

Conference (2010)

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See detail10 Poems
Delville, Michel ULiege; Leskova, Andrea

in Solotruk, Martin (Ed.) Ars Poetica 2014 (2004)

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See detail10 years of advances in nonlinear system identification in structural dynamics: A review
Noël, Jean-Philippe ULiege; Kerschen, Gaëtan ULiege

in Proceedings of ISMA 2016 - International Conference on Noise and Vibration Engineering (2016, September)

Nonlinear system identification is a vast research field, today attracting a great deal of attention in the structural dynamics community. Ten years ago, an MSSP paper reviewing the progress achieved ... [more ▼]

Nonlinear system identification is a vast research field, today attracting a great deal of attention in the structural dynamics community. Ten years ago, an MSSP paper reviewing the progress achieved until then concluded that the identification of simple continuous structures with localised nonlinearities was within reach. The past decade witnessed a shift in emphasis, accommodating the growing industrial need for a first generation of tools capable of addressing complex nonlinearities in larger-scale structures. The objective of the present paper is to survey the key developments which arose in the field since 2006 towards developing these tools. [less ▲]

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See detail10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension
Bone, H.G.; Wagman, R.B.; Brandi, M.L. et al

in Lancet Diabetes and Endocrinology (2017), 5

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See detail10 years of temperature monitoring experiments using electrical resistivity tomography: What have we learned?
Hermans, Thomas ULiege; Lesparre, Nolwenn; De Schepper, Guillaume et al

in EarthDoc - Proceedings of the 1st Conference on Geophysics for Geothermal and Renewable Energy Storage (2019, September 11)

The electrical resistivity of the subsurface is dependent on the temperature. This makes electrical resistivity tomography a good candidate for monitoring temperature variations within the context of ... [more ▼]

The electrical resistivity of the subsurface is dependent on the temperature. This makes electrical resistivity tomography a good candidate for monitoring temperature variations within the context of aquifer thermal energy storage or thermal tracer test. In this contribution, we review the advances made in the development of ERT for monitoring heat storage and heat tracing experiments during the last ten years. We highlight the common limitations related to ERT such as the need for a petrophysical relationship for a proper survey design, as well as the concerns related to noise and inversion. We also point towards the solutions available to overcome those limitations and guidelines for successful monitoring experiments. We think this contribution will help practitioners and scientists to make the appropriate choice when designing or exploiting shallow geothermal systems. [less ▲]

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