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See detailThe 19 Feb. 2016 Outburst of Comet 67P/CG: An ESA Rosetta Multi-Instrument Study
Grün, E.; Agarwal, J.; Altobelli, N. et al

in Monthly Notices of the Royal Astronomical Society (2016)

On 19 Feb. 2016 nine Rosetta instruments serendipitously observed an outburst of gas and dust from the nucleus of comet 67P/Churyumov-Gerasimenko. Among these instruments were cameras and spectrometers ... [more ▼]

On 19 Feb. 2016 nine Rosetta instruments serendipitously observed an outburst of gas and dust from the nucleus of comet 67P/Churyumov-Gerasimenko. Among these instruments were cameras and spectrometers ranging from UV over visible to microwave wavelengths, in-situ gas, dust and plasma instruments, and one dust collector. At 9:40 a dust cloud developed at the edge of an image in the shadowed region of the nucleus. Over the next two hours the instruments recorded a signature of the outburst that significantly exceeded the background. The enhancement ranged from 50% of the neutral gas density at Rosetta to factors >100 of the brightness of the coma near the nucleus. Dust related phenomena (dust counts or brightness due to illuminated dust) showed the strongest enhancements (factors >10). However, even the electron density at Rosetta increased by a factor 3 and consequently the spacecraft potential changed from ˜-16 V to -20 V during the outburst. A clear sequence of events was observed at the distance of Rosetta (34 km from the nucleus): within 15 minutes the Star Tracker camera detected fast particles (˜25 m s[SUP]-1[/SUP]) while 100 μm radius particles were detected by the GIADA dust instrument ˜1 hour later at a speed of ~6 m s[SUP]-1[/SUP]. The slowest were individual mm to cm sized grains observed by the OSIRIS cameras. Although the outburst originated just outside the FOV of the instruments, the source region and the magnitude of the outburst could be determined. [less ▲]

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See detail(19) F NMR in vivo spectroscopy reflects the effectiveness of perfusion - enhancing vascular modifiers for improving gemcitabine chemotheraypy
Cron, Greg O.; Ansiaux; MARTINIVE, Philippe ULiege et al

in Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine (2008)

Laboratory of Biomedical Magnetic Resonance and Laboratory of Medicinal Chemistry and Radiopharmacy, Université Catholique de Louvain, UCL, Brussels, Belgium. Nuclear magnetic resonance spectroscopy of ... [more ▼]

Laboratory of Biomedical Magnetic Resonance and Laboratory of Medicinal Chemistry and Radiopharmacy, Université Catholique de Louvain, UCL, Brussels, Belgium. Nuclear magnetic resonance spectroscopy of fluorine-19 ((19)F NMR) has proven useful for evaluating kinetics of fluorinated chemotherapy drugs in tumors in vivo. This work investigated how three perfusion-enhancing vascular modifiers (BQ123, thalidomide, and Botulinum neurotoxin type A [BoNT-A]) would affect the chemotherapeutic efficacy of gemcitabine, a fluorinated drug widely used in human cancer treatment. Murine tumor growth experiments demonstrated that only BoNT-A showed a strong trend to enhance tumor growth inhibition by gemcitabine (1.7 days growth delay, P = 0.052, Student t-test). In accord with these results, (19)F NMR experiments showed that only BoNT-A increased significantly the uptake of gemcitabine in tumors (50% increase, P = 0.0008, Student t-test). Further experiments on gemcitabine kinetics (NMR vs time) and distribution ((19)F MRI) confirmed the uptake-enhancing properties of BoNT-A. The results of this study demonstrate that (19)F NMR can monitor modulation of the pharmacokinetics of fluorinated chemotherapy drugs in tumors. The results also show that (19)F NMR data can give a strong indication of the effectiveness of perfusion-enhancing vascular modifiers for improving gemcitabine chemotherapy in murine tumors. (19)F NMR is a promising tool for preclinical evaluation of such vascular modifiers and may ultimately be used in the clinic to monitor how these modifiers affect chemotherapy. 2007 Wiley-Liss, Inc PMID: 18050344 [PubMed - indexed for MEDLINE] [less ▲]

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See detailThe 19-27 Amino-Acid Segment Of Gp51 Adopts An Amphiphilic Structure And Plays A Key Role In The Fusion Events Induced By Bovine Leukemia-Virus
Voneche, V.; Callebaut, I.; Kettmann, Richard ULiege et al

in Journal of Biological Chemistry (1992), 267(21),

Previous results indicate that the external glycoprotein gp51 of bovine leukemia virus plays an important role in the process of cell fusion induced by bovine leukemia virus (Bruck, C., Mathot, S ... [more ▼]

Previous results indicate that the external glycoprotein gp51 of bovine leukemia virus plays an important role in the process of cell fusion induced by bovine leukemia virus (Bruck, C., Mathot, S., Portetelle, D., Berte, C., Franssen, J. D., Herion, P., and Burny, A. (1982) Virology 122, 342-352; Voneche, V., Portetelle., D., Kettmann, R., Willems, L., Limbach, K., Paoletti, E., Ruysschaert, J. M., Burny, A., and Brasseur, R. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 3810-3814) and suggest that a region encompassing residues 23 and 25 of gp51 is involved in this process (Portetelle, D., Couez, D., Bruck, C., Kettmann, R., Mammerickx, M., Van der Maaten, M., Brasseur, R., and Burny, A. (1989) Virology 169, 27-33; Mamoun, R., Morisson, M., Rebeyrotte, N., Busetta, B., Couez, D., Kettmann, R., Hospital, M., and Guillemain, B. (1990) J. Virol. 64, 4180-4188). X-ray diffraction studies performed on envelope glycoproteins of influenza virus indicate that the NH2-terminal part of the external glycoprotein lies very close to the fusion peptide. The same overall structure seems to exist in human immunodeficiency virus as suggested by site-directed mutagenesis followed by syncytia induction assays. Our theoretical studies indicate that a segment expanding between residues 19 and 27 of gp51 probably adopts an amphipathic beta-strand structure. We hypothesize that the amphipathic 19-27 structure of gp51 plays an important role in the process of membrane fusion by interacting with the fusion peptide or with another region of gp30. Mutational analysis disrupting the amphipathy of the 19-27 region strongly altered the fusogenic capacity of the gp51-gp30 complex. [less ▲]

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See detailA 19-miRNA SIGNATURE PREDICTS RELAPSE IN AVERAGE RISK PRE-B ACUTE LYMPHOBLASTIC LEUKEMIA
Lammens, TL; Ghazavi, F; Suciu, S et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2012), 2012(4), 78

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See detail19. Les femmes supportent-elles moins l'alcool que les hommes ?
DEVILLE, Marine ULiege; DENOOZ, Raphael ULiege; Charlier, Corinne ULiege

in Seutin, Vincent; Scuvée-Moreau, Jacqueline; Quertemont, Etienne (Eds.) L'alcool en questions (2015)

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See detail19. Oiseaux
Lougbegnon, Toussaint; Libois, Roland ULiege

in Neuenschwander, Peter; Sinsin, Brice; Goergen, Georg (Eds.) Protection de la nature en Afrique de l'Ouest: une liste rouge pour le Bénin (2011)

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See detail1903-2003. Cent ans de géographie à l’Université de Liège : changements et permanences
Merenne-Schoumaker, Bernadette ULiege

in Bulletin de la Société Géographique de Liège (2004), (44), 125-127

Address of the 100th anniversary of the Institute of Geography, University of Liege

Detailed reference viewed: 21 (2 ULiège)
See detail1905-2005 : de la tuberculose au sida
Jaminon, Martine ULiege; Brouwir, Christine ULiege; Dumont, Pascal

Learning material (2005)

plaquette de l'exposition " 1905- 2005 : de la tuberculose au sida"

Detailed reference viewed: 45 (16 ULiège)
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See detail1910 : Solitudini e seduzioni fatali. Leila e Forse che sì forse che no
Curreri, Luciano ULiege

in Neiger, Ada (Ed.) All'insegna della femme fatale (1994)

Detailed reference viewed: 17 (0 ULiège)
See detail1911. Les Hautes-Fagnes en feu. Chronique de l’incendie à travers la presse régionale
Klauser, Klaus Dieter; Nekrassoff, Serge ULiege; Rauw, Bernard et al

Book published by Haute Ardenne (2011)

L’été de 1911 est caniculaire. Alors que les premiers défenseurs des Hautes- Fagnes s’organisent, le feu s’y déclare au milieu du mois d’août et refuse de se laisser maîtriser. Il ne cessera qu’en ... [more ▼]

L’été de 1911 est caniculaire. Alors que les premiers défenseurs des Hautes- Fagnes s’organisent, le feu s’y déclare au milieu du mois d’août et refuse de se laisser maîtriser. Il ne cessera qu’en septembre, après plusieurs regains. Des centaines d’hectares seront consumés. Le contingent de soldats allemands et belges envoyés lutter contre les flammes s’élèvera à plus de 2.000 hommes. Le spectacle des flammes devient rapidement une attraction. Mais le feu se montre un adversaire redoutable. Les efforts consentis ne suffisent pas à le contenir. Il se joue des milliers de bras armés de pelles, il s’allie au vent pour enjamber les tranchées coupe-feu creusées en hâte. Il ne connaît pas les frontières politiques. Les troupes prussiennes et belges se côtoient. Elles ont leur bivouac au Mont-Rigi, à la Baraque-Michel, à la Maison du Sabotier. Touristes et curieux de toutes espèces tentent d’atteindre au plus près les lieux du sinistre pour mieux contempler le spectacle et les centaines de combattants du feu en action. Pendant les moments les plus critiques, la presse publie des comptes rendus quotidiens. [less ▲]

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See detail1914-1918, La Grande Guerre vue de la Province de Liège et de Belgique
Pirot, Pascal ULiege; Province de Liège, Enseignement

Learning material (2014)

Detailed reference viewed: 46 (11 ULiège)
See detail1914-1918: La Belgique dans les cartes postales
Delhalle, Sophie ULiege

Conference given outside the academic context (2015)

Cette conférence a pour but de présenter les diverses images de la Belgique reproduites sur les cartes postales pendant la Première Guerre mondiale.

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See detail1914-2014. Cent ans de mayorat à Waremme
Jonkers, Lionel ULiege; Lanneau, Catherine ULiege

Book published by Imprimerie provinciale (2014)

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See detail1915-2015: Het verhaal van de Belgische militaire inlichtingen- en veiligheidsdienst
Cools, Marc; Van Acker, Kathleen; Stans, David ULiege et al

Book published by Maklu (2015)

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See detail192-Ir or 125-I Prostate Brachytherapy as a Boost to External Beam Radiotherapy in Locally Advanced Prostatic Cancer: A Dosimetric Point of View
Nickers, Philippe ULiege; Thissen, Benedicte ULiege; Jansen, Nicolas ULiege et al

in Radiotherapy & Oncology (2006), 78(1), 47-52

PURPOSE: This work aims at comparing the dosimetric possibilities of 125I or 192Ir prostate brachytherapy (Bt) as a boost to external beam radiotherapy in the treatment of locally advanced adenocarcinoma ... [more ▼]

PURPOSE: This work aims at comparing the dosimetric possibilities of 125I or 192Ir prostate brachytherapy (Bt) as a boost to external beam radiotherapy in the treatment of locally advanced adenocarcinoma. METHODS AND MATERIALS: From 1/1997 to 12/2002, 260 patients were treated. Until 12/2001 a low dose rate (LDR) treatment with 192Ir wires was used, later replaced by a high dose rate (HDR) delivered with an 192Ir stepping source technology. For the present work, we selected 40 patients including the last 20 treated, respectively, by LDR and HDR. The planning CT Scans of all these 40 patients were transferred into the 3D Prowess system for 125I permanent implants design according to the Seattle method. The reference data for dosimetric comparisons were the V100 and the prescribed dose for 192Ir as well as the dose delivered with 125I techniques to the 192Ir V100. We compared V100-150 data as well as doses to the organs at risks (OR) and cold spots (CS). RESULTS: The V100 is 85.3+/-8% for 192Ir LDR and 96+/-2% for HDR techniques (P < 0.0001). In comparison with 125I, the 192Ir LDR mode induces higher hyperdosage volumes inside the CTV but also more CS, while maximal doses to urethra and rectum are, respectively, 17 and 39% less with 125I (P < 0.0001). In comparison with the 192Ir HDR mode, 125I Bt induces higher hyperdosage volumes and slightly more CS deliberately planned around the bladder neck. If delivered doses to urethra are identical, those to the 20% anterior part of the rectum are 33% less with 125I (P < 0,0001). The 125I Bt technique was only possible in 24 out of the 40 patients studied due to pelvic bone arch interference. CONCLUSIONS: At the present time, there is no evident dosimetric superiority of one Bt method when all the criteria are taken into account. However, improving Bt techniques to implant any prostatic size could found the superiority of the 125I or permanent implants. 125I indeed allows large hyperdosage volumes inside the CTV in comparison with 192Ir HDR techniques while lowering doses to OR and minimizing CS. [less ▲]

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See detail1924 : Marcel Thiry publie Toi qui pâlis au nom de Vancouver. « Docteur, j’ai un pied dans le XIXe neuvième siècle »
Purnelle, Gérald ULiege

in Bertrand, Jean-Pierre; Biron, Michel; Denis, Benoît (Eds.) et al Histoire de la littérature belge francophone : 1830-2000 (2003)

Detailed reference viewed: 88 (5 ULiège)
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See detail1929 et le populisme aux Etats-Unis. Les cas du père Coughlin et de Huey Long
Jamin, Jérôme ULiege

in Provenzano, François; Goin, Emilie (Eds.) Usages du peuple (2017)

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See detail192ir Low Dose Rate Brachytherapy for Boosting Locally Advanced Prostate Cancers after External Beam Radiotherapy: A Phase Ii Trial
Nickers, Philippe ULiege; Coppens, Luc ULiege; De Leval, Jean ULiege et al

in Radiotherapy & Oncology (2006), 79(3), 329-34

BACKGROUND AND PURPOSE: To evaluate on 201 locally advanced prostatic cancers prospectively treated in a phase II trial, the efficacy of a combination of external beam radiotherapy (39.6 Gy) and (192)Ir ... [more ▼]

BACKGROUND AND PURPOSE: To evaluate on 201 locally advanced prostatic cancers prospectively treated in a phase II trial, the efficacy of a combination of external beam radiotherapy (39.6 Gy) and (192)Ir low dose rate brachytherapy (Bt) (40-45 Gy). PATIENTS AND METHODS: Sixty-four patients were included in the intermediate prognosis group with only one of the following adverse factors (PSA > 10 ng/ml, Gleason score > or = 7 or clinical stage > or =T2b) and 137 in the unfavourable group when at least two of these factors were present. RESULTS: The actuarial 4 years biochemical no evidence of disease is 82.8% for the entire population. It is, respectively, 97 and 76% in the intermediate and unfavourable prognosis groups (P < 0.0001). Grade > or =3 late urinary complications occurred in 13 patients (6.5%). Eight patients (4%) presented late grade 2 rectal complications but no grades 3-5 was observed. CONCLUSIONS: Even if an alpha/beta of 1.5-3 Gy theoretically favours the use of a high dose rate mode of irradiation, the early results presented here are as good as those reported for similar groups of patients with high dose rate treatments. Late toxicity is identical but our urinary toxicity is within the less favourable and rectal toxicity within the most favourable results. We can postulate that while inducing very high hyperdosage regions (V150) mainly focused on the peripheral zone, most of the Bt techniques consist of a more ablative treatment. Many of the radiobiological studies on Bt did not in fact take into account the heterogeneity of irradiation inside the CTV. This study highlights the need to explore pulsed dose rate therapies, permanent implant and new available radioisotopes such as (169)Ytterbium that will offer the safety of low and lower dose rates. The actual late toxicity of the different Bt techniques is not yet inexistent indeed. [less ▲]

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