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See detailα-chloro-ε-caprolactone, a versatile precursor for grafting of aliphatic polyesters
Riva, Raphaël ULiege; Lenoir, Sandrine ULiege; Lecomte, Philippe ULiege et al

Poster (2009, September 17)

Macromolecular engineering is one of the most powerful tool to synthesise many polymers of various architectures and with tailored properties. This contribution aims at reporting on a novel strategy for ... [more ▼]

Macromolecular engineering is one of the most powerful tool to synthesise many polymers of various architectures and with tailored properties. This contribution aims at reporting on a novel strategy for the macromolecular engineering of poly-ε-caprolactone (PCL) which is based on the use of a dual monomer / initiator compound, α-chloro-ε-caprolactone (αClεCL). Indeed, αClεCL is not only polymerizable by ring opening initiated by metal alkoxides, but it is also an initiator for the atom transfer radical polymerization (ATRP) of vinyl monomers, so leading easily to the synthesis of macromonomers. Polystyrene macromonomer has been prepared by this method and successfully copolymerized with ε-caprolactone (εCL) with formation of the corresponding grafted PCL. αClεCL is also a precursor of copolyesters with εCL that bear pendant chlorides. These (co)polyesters have been used as macroinitiators for the ATRP of methyl methacrylate in order to synthesise the corresponding graft copolymer. On the other hand, the pendant chlorides of poly(αClεCL-co-εCL) copolyesters were easily converted into azide with formation of the corresponding azide bearing copolyester. This copolyester was then reacted with an alkyne bearing an ATRP initiator by “Click chemistry”. The conversion of chlorides into more efficient ATRP initiators led to the improvement of the initiation efficiency of the macroinitiator. [less ▲]

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See detailΆΛΟΓΕΥΕΣΘΑΙ
Delcourt, Marie ULiege

in Revue Belge de Philologie et d'Histoire (1973), 51(1), 51-55

Detailed reference viewed: 16 (6 ULiège)
See detailβ 5 tubulin and 15-protofilament microtubules appeared in supporting cells of the Corti’s organ during development in rodents
Renauld, Justine ULiege; Thelen, Nicolas ULiege; Johnen, Nicolas et al

Conference (2014, August 31)

A feature of the organ of Corti’s supporting cells is the presence of an abundant cytoskeleton which is mainly composed of microtubules. These supporting cells have also been shown to contain a minor ... [more ▼]

A feature of the organ of Corti’s supporting cells is the presence of an abundant cytoskeleton which is mainly composed of microtubules. These supporting cells have also been shown to contain a minor mammalian tubulin, the β5-tubulin [1], recently related as a biomarker for cancer outcome [2] and cell proliferation [3]. It was shown that a β-tubulin isoform can specified the microtubule architecture, such as the expression of the Moth β2 in the Drosophila testes imposed the 16 protofilaments (16pf) structure on the corresponding subset of Drosophila microtubules, which normally contain 13pf [4]. Moreover, supporting cell microtubules are formed by 15pf instead of the canonical 13, a unique fact among vertebrates [5]. Such a protofilament configuration has been observed in C. elegans’ neurons which are responsible for the mechanosensory sense of touch [6]. It was also shown that these 15pf microtubules were essential to the proper functioning of these mechanosensory neurons [6]. To determine the role of this particular tubulin in the auditory organ and its possible involvement in the formation of the unusual 15pf microtubules of supporting cells, we studied the spatiotemporal localization of β5-tubulin during development in rats from embryonic day 18 until P25 (25th postnatal day). We also analyzed the localization of β5-tubulin mRNA expression in the Corti’s organ. Then we examined the fine structure of microtubules at the electron microscope level. For these experiments, we used an early postnatal stage and a late postnatal stage. Our results showed that β5-tubulin, contrary to other β-tubulins, had a unique distribution in the cochlea. This β-tubulin appeared at a postnatal stage, before the opening of the Corti’s tunnel and being restricted to supporting cells, especially in pillar and Deiters cells,. The same localization of β5-tubulin mRNA was observed by in Situ Hybridization. Electron microscopy indicated further that Pillar and Deiters cells were composed by 15-protofilament microtubules at the late postnatal stage (P25). In conclusion, all these data strongly suggest that there is a relationship between the presence of β5-tubulin and 15-protofilament microtubules in the supporting cells of the auditory organ. Further studies are now needed to elucidate their role. [less ▲]

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See detailβ Cephei stars and SPBs: excited modes in exciting stars
De Ridder, J.; Aerts, C.; De Cat, P. et al

Poster (2000, September 25)

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See detailLa β-alanine dans des épreuves isocinétiques et de sauts répétés, (in)utile?
Paulus, Julien ULiege; Schwartz, Cédric ULiege; Paquot, Nicolas ULiege et al

Poster (2017, October 30)

Introduction La β-alanine (β-A), acide aminé précurseur de la carnosine, a fait l'objet d'un nombre important d'études sans néanmoins parvenir à un consensus quant à son influence sur la performance [1-6 ... [more ▼]

Introduction La β-alanine (β-A), acide aminé précurseur de la carnosine, a fait l'objet d'un nombre important d'études sans néanmoins parvenir à un consensus quant à son influence sur la performance [1-6] et/ou son mécanisme d'action [7]. Notre étude a pour but d'affiner la connaissance de son impact sur des performances maximales lors d'épreuves isocinétiques et de sauts prolongées: les personnes ayant une faible résistance à la fatigue neuromusculaire bénéficieraient-elles davantage des effets de la β-A? Méthodes Neuf hommes (24,5 ± 1,2 ans, 182,1 ± 6,6 cm, 80,2 ± 9,9 kg), ont réalisé deux épreuves d'exploration de la fatigue neuromusculaire avec 48h à 72h de repos entre chaque: un test analytique mono-articulaire, gold standard de l'évaluation musculaire, et une épreuve poly-articulaire dite "fonctionnelle". Ces deux épreuves, complémentaires de par les informations qu'elles permettent d'obtenir, sont respectivement un test isocinétique de résistance à la fatigue (30 extensions/flexions maximales de genou en concentrique à 180°.s-1 sur une amplitude de 100° sur Cybex Humac CSMI) [8] et un test de countermovement jump répétés (35 sauts maximaux enclenchés toutes les 1,82 secondes). Chaque sujet a réalisé quatre fois chaque testing: avant/après 14 jours de supplémentation en β-A (5g/j.) et avant/après 14 jours de prise d'un placebo (lactose) sous forme d'un crossover randomisé en double aveugle avec un wash-out de 14 jours. Résultats Aucun effet global de la supplémentation en β-A n'a été observé, que ce soit pour l'épreuve isocinétique (entre autres, somme du travail total des extenseurs: ES Cohen = 0,06 [CI95%: -0,57/0,68]; Magnitude-Based Inference (MBI) Hopkins: P (positif) 31% / T (trivial) 51% / N (négatif) 18%) ou de sauts répétés (entre autres, somme des hauteurs des 35 sauts: ES Cohen = -0,09 [CI95%: -0,47/0,28]; MBI: P 5% / T 68% / N 26%). Une corrélation négative (inversement proportionnelle), forte et statistiquement significative a néanmoins été observée entre l'impact de la β-A sur la performance et la capacité de résistance à la fatigue neuromusculaire pour l'épreuve isocinétique (entre autres, pente de la régression linéaire du travail total & différence entre somme du travail total des extenseurs avec β-A et placebo: rPearson = - 0,85 [CI95%: -0,97/-0,44] avec une p-value de 0,002). Pour l'épreuve de sauts répétés, les résultats ne sont pas significatifs (rPearson = - 0,31 [CI95%: -0,81/0,44] avec une p-value de 0,409). [less ▲]

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See detailβ-arrestin2 recruitment at the β2 adrenergic receptor: a luciferase complementation assay adapted for undergraduate training in pharmacology
Ferraiolo, Mattia; Beckers, Pauline; Marquet, Nicolas et al

in Pharmacology Research and Perspectives (2021), 9(1),

In the context of pharmacology teaching, hands-on activities constitute an essential complement to theoretical lectures. Frequently, these activities consist in exposing fresh animal tissues or even ... [more ▼]

In the context of pharmacology teaching, hands-on activities constitute an essential complement to theoretical lectures. Frequently, these activities consist in exposing fresh animal tissues or even living animals to selected drugs and qualitatively or quantitatively evaluating functional responses. However, technological advancements in pharmacological research and the growing concerns for animal experimentation support the need for innovative and flexible in vitro assays adapted for teaching purposes. We herein report the implementation of a luciferase complementation assay enabling to dynamically monitor β-arrestin2 recruitment at the β2 adrenergic receptor in the framework of pharmacological training at the faculty of Pharmacy and Biomedical Sciences. The assay allowed students to quantitatively characterize the competitive antagonism of propranolol, and to calculate pEC50, pKB and pA2 values after a guided data-analysis session. Moreover, the newly implemented workshop delivered highly reproducible results and were generally appreciated by students. As such, we report that the luciferase complementation-based assay proved to be a straightforward, robust and cost-effective alternative to experiments performed on animal tissues, constituting a useful and flexible tool to enhance and update current hands-on training in the context of pharmacological teaching. [less ▲]

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See detailβ-Lactam-induced Proteus L-forms
Ghuysen, Jean-Marie ULiege; Nguyen-Distèche, Martine ULiege; Rousset, André

in Madoff, Sarabelle (Ed.) The Bacterial L-Forms, vol. 17 (1986)

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See detailβ-Lactamase expression in Streptomyces cacaoi
Urabe, Hiroaki; Lenzini, Mauro V; Mukaide, Masakazu et al

in Journal of Bacteriology (1990), 172(11), 6427-6434

Plasmids were prepared by inserting genomic DNA fragments from Streptomyces cacaoi within the mel gene of plasmid pIJ702. The inserted DNA fragments contain the beta-lactamase-encoding bla gene and ... [more ▼]

Plasmids were prepared by inserting genomic DNA fragments from Streptomyces cacaoi within the mel gene of plasmid pIJ702. The inserted DNA fragments contain the beta-lactamase-encoding bla gene and upstream nucleotide sequences of various lengths. The transcription start point of bla was identified by nuclease S1 mapping. Upstream nucleotide sequences of sufficient lengths had an enhancing effect on beta-lactamase production by the Streptomyces host. The dot blot hybridization assay revealed that this effect was exerted at the transcriptional level. Experimental evidence strongly suggests that the underlying mechanism involves, at least in part, one or several trans-acting elements. In one of the constructs, in which the upstream nucleotide sequence was reduced to 0.3 kb, the bla promoter was present but the bla gene was expressed by readthrough from a promoter, possibly the mel promoter, of the pIJ702 vector. [less ▲]

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See detailβ-lactamases de classe D : substrats, inhibiteurs, et modifications
Kerff, Frédéric ULiege

Scientific conference (2011, November 07)

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See detailβ3 integrin sequence variation and rodent susceptibility to hantaviruses
Pagès, Marie ULiege; Tatard, Caroline; Galan, Maxime et al

Poster (2010, May)

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See detail*/βi'n‑aki‑a/ s.f. « produit du pressurage du raisin »
Delorme, Jérémie ULiege

in Buchi, Eva; Schweickard, Wolfgang (Eds.) Dictionnaire Étymologique Roman (DÉRom) (2010)

Detailed reference viewed: 21 (2 ULiège)
See detail*/'βin‑u/ s.amb. « boisson résultant de la fermentation alcoolique du moût ou du marc de raisin »
Delorme, Jérémie ULiege

in Buchi, Eva; Schweickard, Wolfgang (Eds.) Dictionnaire Étymologique Roman (DÉRom) (2011)

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See detail*/'βɔl‐a‐/ v.intr. « exécuter un (des) mouvement(s) dans l'air ; être projeté dans l'air »
Baiwir, Esther ULiege

in Buchi, Eva; Schweickard, Wolfgang (Eds.) Dictionnaire Étymologique Roman (DÉRom) (2014)

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See detail*/'βɔstru/
Aresti, Alessandro ULiege; Dworkin, Steve

in Buchi, Éva; Schweickard, Wolfgang (Eds.) Dictionnaire Étymologique Roman (DÉRom) 2. Pratique lexicographique et réflexions théoriques (2017)

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See detailβ‐Lactam Antibiotics
Terrak, Mohammed ULiege; Frère, Jean-Marie ULiege

in Offermanns, S.; Rosenthal, W. (Eds.) Encyclopedia of Molecular Pharmacology (2021)

Detailed reference viewed: 45 (7 ULiège)
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See detailThe γ Dor stars as revealed by Kepler: A key to reveal deep-layer rotation in A and F stars
Salmon, Sébastien ULiege

Conference (2016, December 01)

The γ Dor pulsating stars present high-order gravity modes, which make them important targets in the intermediate- and low-mass main-sequence region of the Hertzsprung-Russell diagram. Whilst we have only ... [more ▼]

The γ Dor pulsating stars present high-order gravity modes, which make them important targets in the intermediate- and low-mass main-sequence region of the Hertzsprung-Russell diagram. Whilst we have only access to rotation in the envelope of the Sun, the g modes of γ Dor stars can in principle deliver us constraints on the inner layers. With the puzzling discovery of unexpectedly low rotation rates in the core of red giants, the γ Dor stars appear now as unique targets to explore internal angular momentum transport in the progenitors of red giants. Yet, the γ Dor pulsations remain hard to detect from the ground for their periods are close to 1 day. While the CoRoT space mission first revealed intriguing frequency spectra, the almost uninterrupted 4-year photometry from the Kepler mission eventually shed a new light on them. It revealed regularities in the spectra, expected to bear signature of physical processes, including rotation, in the shear layers close to the convective core. We present here the first results of our effort to derive exploitable seismic diagnosis for mid- to fast rotators among γ Dor stars. We confirm their potential to explore the rotation history of this early phase of stellar evolution. [less ▲]

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See detailThe γ Dor stars as revealed by Kepler: A key to reveal deep-layer rotation in A and F stars
Salmon, Sébastien ULiege; Ouazzani, R.-M.; Antoci, V. et al

in EPJ Web of Conferences (2017, September 08), 152

Detailed reference viewed: 34 (6 ULiège)