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See detailCardiographe
Fredericq, Léon ULiege

in Richet, Charles (Ed.) Dictionnaire de physiologie. 003. Tome III (1898)

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See detailCardiological and general health status in preschool- and school-age children after neonatal arterial switch operation
Hovels-Gurich, H. H.; SEGHAYE, Marie-Christine ULiege; Dabritz, S. et al

in European Journal of Cardio - Thoracic Surgery (1997), 12(4), 593-601

OBJECTIVE: Cardiological and general health status 3-9 years after neonatal arterial switch operation for transposition of the great arteries should be evaluated by non-invasive methods. METHODS: A total ... [more ▼]

OBJECTIVE: Cardiological and general health status 3-9 years after neonatal arterial switch operation for transposition of the great arteries should be evaluated by non-invasive methods. METHODS: A total of 77 unselected children with intact ventricular septum (75.3%) or ventricular septal defect (24.7%) without or with aortic isthmic stenosis (5.2%) were prospectively examined 3.2-9.4 years (5.4 +/- 1.6) after neonatal switch. Clinical pediatric and cardiological examination, standard and 24 h Holter electrocardiogram, M-mode, 2D-, Doppler and colour Doppler echocardiography were performed. Outcome data were compared to published normals. RESULTS: Reoperation rate was 2.6%, 96.1% were without limitation of physical activity and 98.7% without medication. Compared to normals, growth was adequate, weight and head circumference were slightly reduced. After median sternotomy, 23.4% had abnormal thoracic configuration (16.9% asymmetry, 6.5% funnel chest). ECG and Holter: 93.5% were in sinus, 6.5% in ectopic atrial or junctional rhythm. Incidence of complete right bundle branch block was 15.8% in patients with ventricular septal defect and 5.2% in those without. Ischemic ST-T changes during exercise due to coronary artery occlusion and evidence of old myocardial infarction were found in 1 patient (1.3%) each. Occasional atrial ectopy was found in 27.4%, ventricular ectopy in 15.3%: occasional in 12.5% and frequent (> 30/h) in 2.8% presenting bigemini, couplets and short runs of ventricular tachycardia at rest and during exercise. Echocardiography: Left ventricular function was normal in all. Endsystolic diameter of neoaortic valve annulus was beyond 90% confidence interval for controls in 79.2%, neoaortic root diameter in 100%. Mild aortic insufficiency was seen in 10.4%. No correlation was found between aortic insufficiency and aortic dilatation. Neoaortic stenosis was not seen, mild residual coarctation after end-to-end-anastomosis was found in 2.6%, native coarctation corrected later on in 1.3%. Supravalvular pulmonary stenosis was seen in 29.9% (19.5% trivial, 7.8% mild, 2.6% moderate), mild subvalvular pulmonary stenosis in 1.3%, pulmonary insufficiency in 2.6%. CONCLUSION: The study confirms good midterm results after neonatal arterial switch operation for transposition with or without ventricular septal defect. Long-term observation is necessary to assess rhythm, coronary artery and myocardial function as well as development of neo-aorta and pulmonary artery system. [less ▲]

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See detailCardiologie des équidés
Amory, Hélène ULiege; Sandersen, Charlotte ULiege

Learning material (2010)

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See detailLa cardiologie preventive: strategies chez l'enfant
Massin, M.; Vandoorne, Chantal ULiege; Coremans, C. et al

in Revue Médicale de Liège (2002), 57(4), 207-12

The importance of preventive cardiology in youth has been established by several critical observations: there is evidence that the atherogenic process begins in childhood, and that the degree of ... [more ▼]

The importance of preventive cardiology in youth has been established by several critical observations: there is evidence that the atherogenic process begins in childhood, and that the degree of atherogenesis is related to measurable risk factors present during childhood. The literature indicated that long-range prevention of atheroselerosis and its sequelae by control of those risk factors should begin in childhood. This article reviews the established risk factors, the identification of high-risk individuals, public health strategies for the promotion of health in the French Community of Belgium and treatment of high-risk individuals. [less ▲]

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See detailCardiologists and smoking
Kesteloot, H.; Pierard, Luc ULiege

in Acta Cardiologica (2003), 58(3), 177-177

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See detailCARDIOLOGY GUIDELINES 2013: AN ECHOCARDIOGRAPHIC PERSPECTIVE
PTONSKA-GOSCINIAK, EDYTA; LANCELLOTTI, Patrizio ULiege; HABIB, GILBERT

Book published by MEDICAL TRIBUNE POLSKA (2013)

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Alkerwi, A; Albert, Adelin ULiege; Guillaume, Michèle ULiege

in Gasparyan, AY (Ed.) Cardiovascular Risk Factors (2011)

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See detailCardiomyocyte-restricted overexpression of endothelial nitric oxide synthase (NOS3) attenuates beta-adrenergic stimulation and reinforces vagal inhibition of cardiac contraction.
MASSION, Paul ULiege; Dessy, Chantal; Desjardins, Fanny et al

in Circulation (2004), 110(17), 2666-72

BACKGROUND: In the heart, nitric oxide synthases (NOS) modulate cardiac contraction in an isoform-specific manner, which is critically dependent on their cellular and subcellular localization. Defective ... [more ▼]

BACKGROUND: In the heart, nitric oxide synthases (NOS) modulate cardiac contraction in an isoform-specific manner, which is critically dependent on their cellular and subcellular localization. Defective NO production by NOS3 (endothelial NOS [eNOS]) in the failing heart may precipitate cardiac failure, which could be reversed by overexpression of NOS3 in the myocardium. METHODS AND RESULTS: We studied the influence of NOS3 in relation to its subcellular localization on the function of cardiomyocytes isolated from transgenic mice overexpressing NOS3 under the alpha-myosin heavy chain promoter (NOS3-TG). Immunoblot analysis demonstrated moderate (5-fold) NOS3 overexpression in cardiomyocytes from NOS3-TG heterozygotes. Caveolar localization of transgenic eNOS was demonstrated by immunofluorescence, coimmunoprecipitation with caveolin-3, sucrose gradient fractionation, and immunogold staining revealed by electron microscopy. Compared with wild-type littermate, contractility of NOS3-TG cardiomyocytes analyzed by videomicroscopy revealed a lower incidence of spontaneous arrhythmic contractions (n=32, P<0.001); an attenuation of the beta-adrenergic positive inotropic response (isoproterenol, 10(-7) mol/L: 62.1+/-7.8% versus 90.8+/-8.0% of maximum Ca2+ response; n=10 to 17; P<0.05); a potentiation of the muscarinic negative chronotropic response (carbamylcholine, 3.10(-8) mol/L: -63.9+/-14% versus -27.7+/-5.6% of basal rate; n=8 to 10; P<0.05), confirmed by telemetry in vivo; and an attenuation of the accentuated antagonism of beta-adrenergically stimulated contraction (-14.6+/-1.5% versus -3.5+/-1.5; n=7 to 11; P<0.05). Cardiomyocyte NOS inhibition reversed all 4 effects (P<0.05). CONCLUSIONS: Moderate overexpression of NOS3, targeted to caveolae in murine cardiomyocytes, potentiates the postsynaptic muscarinic response and attenuates the effect of high concentrations of catecholamines. Cardiomyocyte NOS3 may represent a promising therapeutic target to restore the sympathovagal balance and protect the heart against arrhythmia. [less ▲]

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See detailLa cardiomyopathie du cirrhotique : un bref aperçu
MARCHETTA, Stella ULiege; DELWAIDE, Jean ULiege; LANCELLOTTI, Patrizio ULiege

in Revue Médicale de Liège (2015), 2

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See detailCardiomyopathie rythmique recidivante secondaire a une tachycardie ventriculaire idiopathique.
Henrard, S.; Pierard, Luc ULiege

in Archives des maladies du coeur et des vaisseaux (2001), 94(6), 617-21

Tachycardia-induced cardiomyopathy consists in severe ventricular dysfunction and heart failure secondary to incessant or prolonged supraventricular or less frequently ventricular tachycardia in the ... [more ▼]

Tachycardia-induced cardiomyopathy consists in severe ventricular dysfunction and heart failure secondary to incessant or prolonged supraventricular or less frequently ventricular tachycardia in the absence of any cardiac disease. We present here a case of recurrent severe cardiomyopathy secondary to idiopathic ventricular tachycardia. Complete sustained recovery in function was observed after successful radiofrequency ablation of the ventricular tachycardia focus. To the best of our knowledge, this is the first report of recurrent tachycardia-induced cardiomyopathy. The diagnosis, aetiology, physiopathology and mechanisms of tachycardia-induced cardiomyopathy are discussed. Several therapeutic implications are presented. [less ▲]

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See detailCardiomyopathie rythmique.
Henrard, S.; ROBINET, Sébastien ULiege; Pierard, Luc ULiege

in Revue medicale de Liege (2010), 65(12), 672-5

Tachycardia-mediated cardiomyopathy is a form of dilated cardiomyopathy and heart failure induced by a persistent/chronic supraventricular or ventricular tachyarythmia. The incidence and the patho ... [more ▼]

Tachycardia-mediated cardiomyopathy is a form of dilated cardiomyopathy and heart failure induced by a persistent/chronic supraventricular or ventricular tachyarythmia. The incidence and the patho-physiology remain unspecified. Sometimes related to a previous cardiomyopathy, the diagnosis is always retrospective, but important because of the clinical and the significant haemodynamic improvement following the control of heart rate. [less ▲]

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See detailLes cardiomyopathies dans l’espèce bovine
Brihoum, Mounir ULiege; Rollin, Frédéric ULiege; Amory, Hélène ULiege

in Annales de Médecine Vétérinaire (2009), 153(3), 156-163

Cardiomyopathies in cattle are disorders that are sometimes encountered by rural practitioner. They usually lead to cardiac dysfunction, heart failure, arrhythmias and even sudden death. Most of ... [more ▼]

Cardiomyopathies in cattle are disorders that are sometimes encountered by rural practitioner. They usually lead to cardiac dysfunction, heart failure, arrhythmias and even sudden death. Most of cardiomyopathies in cattle are of hereditary, nutritional or toxic origin. Bovine cardiomyopathies may involve only one animal as they may affect several animals of the farm and can cause considerable economic losses either in treatment costs, decrease of zootechnical performances or in mortality. The etiological variability of cardiomyopathies as well as non-specificity of clinical signs often complicate the diagnostic approach of the practitioner. In this paper, a literature review on cardiomyopathies that may occur in cattle is proposed. Their different aetiologies and clinical aspects as well as diagnostic means in affected cattle are discussed [less ▲]

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See detailLa cardiomyoplastie
RADERMECKER, Marc ULiege; Fourny, J.; Limet, Raymond ULiege

in Revue Médicale de Liège (1992), 47(3), 140-4

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See detailCardiopathies congénitales de l'enfant et remodeling myocardique
SEGHAYE, Marie-Christine ULiege

in Revue Médicale de Liège (2014), 69(S2), 3-7

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See detailCardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics.
Bartunek, Jozef; Behfar, Atta; Dolatabadi, Dariouch et al

in Journal of the American College of Cardiology (2013), 61(23), 2329-38

OBJECTIVES: This study sought to evaluate the feasibility and safety of autologous bone marrow-derived and cardiogenically oriented mesenchymal stem cell therapy and to probe for signs of efficacy in ... [more ▼]

OBJECTIVES: This study sought to evaluate the feasibility and safety of autologous bone marrow-derived and cardiogenically oriented mesenchymal stem cell therapy and to probe for signs of efficacy in patients with chronic heart failure. BACKGROUND: In pre-clinical heart failure models, cardiopoietic stem cell therapy improves left ventricular function and blunts pathological remodeling. METHODS: The C-CURE (Cardiopoietic stem Cell therapy in heart failURE) trial, a prospective, multicenter, randomized trial, was conducted in patients with heart failure of ischemic origin who received standard of care or standard of care plus lineage-specified stem cells. In the cell therapy arm, bone marrow was harvested and isolated mesenchymal stem cells were exposed to a cardiogenic cocktail. Derived cardiopoietic stem cells, meeting release criteria under Good Manufacturing Practice, were delivered by endomyocardial injections guided by left ventricular electromechanical mapping. Data acquisition and analysis were performed in blinded fashion. The primary endpoint was feasibility/safety at 2-year follow-up. Secondary endpoints included cardiac structure/function and measures of global clinical performance 6 months post-therapy. RESULTS: Mesenchymal stem cell cocktail-based priming was achieved for each patient with the dose attained in 75% and delivery without complications in 100% of cases. There was no evidence of increased cardiac or systemic toxicity induced by cardiopoietic cell therapy. Left ventricular ejection fraction was improved by cell therapy (from 27.5 +/- 1.0% to 34.5 +/- 1.1%) versus standard of care alone (from 27.8 +/- 2.0% to 28.0 +/- 1.8%, p < 0.0001) and was associated with a reduction in left ventricular end-systolic volume (-24.8 +/- 3.0 ml vs. -8.8 +/- 3.9 ml, p < 0.001). Cell therapy also improved the 6-min walk distance (+62 +/- 18 m vs. -15 +/- 20 m, p < 0.01) and provided a superior composite clinical score encompassing cardiac parameters in tandem with New York Heart Association functional class, quality of life, physical performance, hospitalization, and event-free survival. CONCLUSIONS: The C-CURE trial implements the paradigm of lineage guidance in cell therapy. Cardiopoietic stem cell therapy was found feasible and safe with signs of benefit in chronic heart failure, meriting definitive clinical evaluation. (C-Cure Clinical Trial; NCT00810238). [less ▲]

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See detailCardiopulmonary exercise testing is a better outcome predictor than exercise echocardiography in asymptomatic aortic stenosis.
Domanski, Olivia; Richardson, Marjorie; Coisne, Augustin et al

in International Journal of Cardiology (2017), 227

BACKGROUND: Objective assessment of maximal aerobic capacity using peak oxygen consumption (peak VO2) can be helpful in the management of patients with asymptomatic aortic stenosis (AS). The relationship ... [more ▼]

BACKGROUND: Objective assessment of maximal aerobic capacity using peak oxygen consumption (peak VO2) can be helpful in the management of patients with asymptomatic aortic stenosis (AS). The relationship between peak VO2 and AS severity criteria derived from rest and supine exercise echocardiography (SEE) has never been explored. OBJECTIVES: We aimed to determine whether low peak VO2 (<85% of predicted value) is associated with severity parameters in SEE, and poor clinical outcome. METHODS: Fifty one asymptomatic patients (mean age of 54+/-21years) with moderate to severe aortic stenosis (Vmax>3m/s) and left ventricle ejection fraction>50% prospectively underwent resting and SEE and cardiopulmonary exercise testing (CPX). RESULTS: Peak VO2 was lower than expected (21.9+/-7.4mL/kg/min), i.e. <85% of predicted value in 57% patients, secondary to cardiac limitation in most of them (69%). In multiple regression analysis, age, BMI and female gender were the only independent determinants of peak VO2. Interestingly no parameter derived from SEE was associated with peak VO2. After 21+/-7month follow-up, no patient died, 20 underwent cardiac surgery. Peak VO2<85% of predicted value was associated with lower event free survival compared to normal peak VO2 (57%+/-11% vs 93+/-6%, p=0.036) whereas no exercise echocardiographic parameter could predict such events. Peak VO2>/=85% had a negative predictive value of 97%. CONCLUSION: CPX detects a high proportion of false asymptomatic AS patients with poorer outcome that cannot be predicted by SEE markers of AS severity. Assessment of aerobic capacity should be part of current approach within a "watchful waiting" strategy. [less ▲]

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See detailCardiopulmonary resuscitation
Brichant, Jean-François ULiege

Conference (2006, June)

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See detailCardioPulse: cardiac imaging of adult cancer patients on chemotherapy.
Galderisi, Maurizio; Lancellotti, Patrizio ULiege

in European heart journal (2015), 36(15), 889-90

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See detailCardiorespiratory emergency. Synoptic table for immediate diagnosis and action
Lamy, Maurice ULiege; Lauwers, P.; Mundeleer, P. et al

in Acta Anaesthesiologica Belgica (1980), 31

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See detailCardiorespiratory measurements and indices of oxidative stress in exercising COPD horses
Art, Tatiana ULiege; Kirschvink, Nathalie; Smith, Nicola et al

in Equine Veterinary Journal. Supplement (1999), 30

The effect of a COPD crisis on arterial blood gases, heart rate, lactate and indices of oxidative stress were investigated before, during and 1 h after a 'run up to fatigue' in 6 COPD horses. They were ... [more ▼]

The effect of a COPD crisis on arterial blood gases, heart rate, lactate and indices of oxidative stress were investigated before, during and 1 h after a 'run up to fatigue' in 6 COPD horses. They were investigated twice, randomly: once in acute crisis (C) and once in clinical remission (R). Arterial and mixed venous blood samples were collected and analysed for partial pressures in O2 and CO2. The mixed venous blood was also analysed for plasma lactate (LA) and packed cell volume (PCV), as well as for indices of oxidative stress, i.e. reduced glutathione, glutathione disulphide, glutathione redox ratio (GRR) and lipid hydroperoxides (LPH). The exercise test was an effort of increasing intensity on a treadmill at 0% slope, which was stopped when the horses showed signs of exhaustion. Their performance was evaluated by the number of steps and the running time in the last step. Heart rate was monitored continuously during the test. Blood sampling was performed before, just after and 1 h after the end of the test. The COPD crisis significantly reduced the time to fatigue. However, despite the fact that the exercise intensity and length were lower, peak HR and peak LA were similar in C and R, while arterial hypoxaemia and hypercapnia, and PCV were significantly higher in C, indicating a higher physiological stress in this condition. By contrast, the oxidative stress seemed to be higher in R than in C as suggested by the fact that, 1 h after exercise, GRR and LPH were significantly increased with regards to their pre-exercise values in R and not in C. The fact that exercise did not induce an oxidative stress in C could be partly related to (1) the lower exercise intensity reached by the horses, and (2) to the more severe hypoxaemia experienced in this condition. In conclusion, COPD horses in acute crisis show a significant decrease in performance. The reasons for this exercise intolerance remain unclear, but do not appear to be related to any increase of the oxidative stress in C. [less ▲]

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