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See detailBovine preantral follicles and activin: immunohistochemistry for activin and activin receptor and the effect of bovine activin A in vitro
Hulshof, S. C. J.; Figueiredo, J. R.; Beckers, Jean-François ULiege et al

in Theriogenology (1997), 48

Activin was originally isolated from follicular fluid as a factor stimulating FSH from the pituitary. Recent studies also suggest a local role for activin in the development of preantral and early antral ... [more ▼]

Activin was originally isolated from follicular fluid as a factor stimulating FSH from the pituitary. Recent studies also suggest a local role for activin in the development of preantral and early antral follicles. In the present study, activin and activin receptor immunoreactivity are shown in oocyte and granulosa cells of bovine preantal follicles. In addition, activin immunoreactivity was observed in the theca of secondary follicles. In addition, activin preantral follicles, activin increased follicular growth and granulosa cell proliferation in a dose-dependent manner. This increase was further stimulated by addition of FSH. In conclusion, activin and its receptor are present on bovine follicles, and additional activin stimulates development of those follicles. [less ▲]

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See detailBovine pregnancy-associated glycoprotein plasma concentrations during successful pregnancies after transfer of in vitro-produced bovine embryos
Vos, P.L.M.A.; Perenyi, Zsolt; Jonker, F. H. et al

in Theriogenology (2001), 55(1), 328

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See detailBovine pregnancy-associated glycoprotein profiles as indicators of trophoblastic function after in vitro manipulation or culture
Ectors, Fabien ULiege; Sulon, José; Delval, A. et al

in Reproduction in Domestic Animals (1997, February), 32(1-2), 52

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See detailBovine respiratory disease complex : an european perspective
Lekeux, Pierre ULiege

in Bovine Practitioner (1995), 29

Respiratory disease is the principal cause of loss of young cattle worldwide. The syndrome arises from a number of factors, including those involving the animal, e.g., age, general condition and immune ... [more ▼]

Respiratory disease is the principal cause of loss of young cattle worldwide. The syndrome arises from a number of factors, including those involving the animal, e.g., age, general condition and immune status; its environment, e.g., changes in food, temperature and humidity that lead to stress; and the presence of infectious agents, e.g., bacteria, viruses and mycoplasmas. The syndrome, in a method preferred by the author, can be classified into four grades; Grade 1, subclinical disease; Grade 2, compensated clinical disease (at this stage, the inflammatory reaction generated tends to limit the impact of the disease on the animal); Grade 3, noncompensated clinical disease (at this stage, the inflammatory reaction is excessive and must be controlled); and Grade 4, irreversible clinical disease (which threatens the animal's survival). The increase in frequency and economy impact of bovine respiratory disease complex can be correlated with the escalating industrialization of cattle production. In intensive operations, commingling of animals from multiple sources, exposure to many organisms, stress and management practices are all factors that can lead to disease. The predisposition of cattle, especially beef calves, to respiratory problems is related to their lack of functional pulmonary hardiness. Selection of breeds that demonstrate adequate pulmonary function and sufficient ventilatory reserve may help in the control of the bovine respiratory disease complex, but this approach is difficult to implement and slow to produce results. Prophylactic measures, including vaccination programs and modifying management practices to reduce stress, also have a place in preventing the bovine respiratory disease complex. Unfortunately, these measures are not always easy to put into operation and cannot completely eradicate the problem. Therapeutic strategies to minimize the economy impact of the syndrome include use of appropriate antibacterial therapy, modulation of the pulmonary inflammatory reaction and correction of mechanical disorders. [less ▲]

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See detailBovine Respiratory Disease: from clinic to etiologic diagnosis, a short step
Guyot, Hugues ULiege

in ANEMBE (Ed.) XX Congreso Internacional ANEMBE de Medicina Bovina: 20 encuentros en la evolucion de la medicina bovina (2015, May 08)

Bovine Respiratory Disease, or BRD, are common in young cattle in the first year of life but occurs mainly before 6 months. A peak of incidence is noticed between 2-10 weeks, due to a decline of immunity ... [more ▼]

Bovine Respiratory Disease, or BRD, are common in young cattle in the first year of life but occurs mainly before 6 months. A peak of incidence is noticed between 2-10 weeks, due to a decline of immunity. BRD is associated with the well-known shipping-fever that may come from cumulative stress. This condition can reach 5-20% case fatality rate and a morbidity rate up to 100%. Most of the time, the treatment administered is effective. In other cases, a relapse within 2 weeks, associated or not with mortality, can be observed. BRD induces economic losses with treatments (antibiotics), prevention (vaccination) and mortalities. There are also zootechnical consequences with growth retardation, circulation of infectious agents, and increased sensitivity to other pathogens. Cattle are more susceptible to BRD for many reasons. They have narrow upper airways that increase air speed and allow a deeper colonization of particles in the lower respiratory tract. There is also a link between the digestive and respiratory system in bovines. Inhalation of eructation gaz occurs regularly. The respiratory tract in cattle is more sensitive to endotoxins. In case of rumen acidosis, a paralysis of the mucociliary escalator is observed. Finally, cases such liver abscess or Vena Cava Caudale thrombosis, a metastatic pneumonia can follow. BRD often begins with virus attack, which may be complicated with surroundings bacterial infections. Among the different viral aetiologies, Bovine Respiratory Syncytial Virus (B-RSV), Parainfluenza virus (PI-3), Bovine Herpes Virus (BHV-1 or IBR), Bovine Viral Diarrhoea Virus (BVD, for its immunosuppression effect) are the most frequent encountered. Adenovirus and Coronavirus, BHV-4, Rhinovirus, Reovirus, and Enterovirus can also be present, in a lesser extent. Among bacteriological causes, Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, Trueperella pyogenes, and Mycoplasma bovis (dispar) are commonly met. Chlamydophila and Salmonella dublin can sometimes also provoke pneumonias. An onset of BRD can begin with only an increased rectal temperature. That is why it is recommended to the owner to check for temperature in the different batches of animals. After, other symptoms will appear, such as cough, nasal discharge, dyspnea, etc. BRD can be categorized in 4 clinical grades, from 1 to 4, according to the severity of the disease. Grade I does not need a treatment, as well as grade IV that is so severe that the animal may probably die within a few days. Other scores exist and they also take into account symptoms such cough, rectal temperature, nasal discharge, etc. The grade or score of the disease is important to establish a treatment, a prognosis or an ancillary exam. Measurement of blood L-Lactate (with portable spectrophotometer, e.g. Accutrend-Plus, Cobas, ~150€ and ~3€/test) allows on the field the determination of the grade of BRD as well as prognosis. L-Lactate ≥ 4 mmol/L in calves with BRD (up to 13 months) is associated with grade IV BRD and poor prognosis (death within 3 days) with 95% sensitivity and 80% specificity (Coghe et al., 2000). Another study shows that L-Lactate > 3.7 mmol/L is associated with 44 times more risk to die in calves with BRD, compared to calves with L-Lactate <1.3 mmol/L (Buczinski et al., 2014). BRD is clearly a multifactorial disease. Its management must include the resistance of animal (genetic, nutrition, vaccination), the environment (ventilation, hygiene) and the identification of the infectious agents. This conference is focused on the last topic. [less ▲]

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See detailBovine Staphylococcus aureus: Subtyping, evolution, and zoonotic transfer.
Boss, R.; Cosandey, A.; Luini, M. et al

in Journal of dairy science (2016), 99(1), 515-28

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies using ribosomal spacer (RS)-PCR, however, demonstrated in Swiss cows that ... [more ▼]

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies using ribosomal spacer (RS)-PCR, however, demonstrated in Swiss cows that Staph. aureus isolated from bovine intramammary infections are genetically heterogeneous, with Staph. aureus genotype B (GTB) and GTC being the most prominent genotypes. Furthermore, Staph. aureus GTB was found to be contagious, whereas Staph. aureus GTC and all the remaining genotypes were involved in individual cow disease. In addition to RS-PCR, other methods for subtyping Staph. aureus are known, including spa typing and multilocus sequence typing (MLST). They are based on sequencing the spa and various housekeeping genes, respectively. The aim of the present study was to compare the 3 analytic methods using 456 strains of Staph. aureus isolated from milk of bovine intramammary infections and bulk tanks obtained from 12 European countries. Furthermore, the phylogeny of animal Staph. aureus was inferred and the zoonotic transfer of Staph. aureus between cattle and humans was studied. The analyzed strains could be grouped into 6 genotypic clusters, with CLB, CLC, and CLR being the most prominent ones. Comparing the 3 subtyping methods, RS-PCR showed the highest resolution, followed by spa typing and MLST. We found associations among the methods but in many cases they were unsatisfactory except for CLB and CLC. Cluster CLB was positive for clonal complex (CC)8 in 99% of the cases and typically positive for t2953; it is the cattle-adapted form of CC8. Cluster CLC was always positive for tbl 2645 and typically positive for CC705. For CLR and the remaining subtypes, links among the 3 methods were generally poor. Bovine Staph. aureus is highly clonal and a few clones predominate. Animal Staph. aureus always evolve from human strains, such that every human strain may be the ancestor of a novel animal-adapted strain. The zoonotic transfer of IMI- and milk-associated strains of Staph. aureus between cattle and humans seems to be very limited and different hosts are not considered as a source for mutual, spontaneous infections. Spillover events, however, may happen. [less ▲]

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See detailA bovine thymic lymphosarcoma case showing a negative serological response to bovine leukemia virus antigens, in a herd with high incidence of enzootic bovine leukosis.
Mammerickx, Marc; Burny, Arsène; Kettmann, Richard ULiege et al

in Zentralblatt für Veterinarmedizin. Reihe B = Journal of Veterinary Medicine. Series B (1981), 28

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See detailBovine tuberculosis prevalence survey on cattle in the rural livestock system of Torodi (Niger).
Boukary, Abdou Razac; Thys, Eric; Abatih, Emmanuel et al

in PLoS ONE (2011), 6(9), 24629

BACKGROUND: Bovine tuberculosis (BTB) is a widespread zoonosis in developing countries but has received little attention in sub-Saharan Africa, especially in Niger. Recent investigations confirmed the ... [more ▼]

BACKGROUND: Bovine tuberculosis (BTB) is a widespread zoonosis in developing countries but has received little attention in sub-Saharan Africa, especially in Niger. Recent investigations confirmed the high incidence of the disease in cattle slaughtered in an abattoir in Niamey. The fact that most of the animals in which M. bovis has been identified were from the rural area of Torodi implied the existence of a probable source of BTB in this region. This study aimed to determine the prevalence of BTB infection in cattle and to identify risk factors for infection in human and cattle populations in Torodi. METHODS AND PRINCIPAL FINDINGS: A survey was carried out at the level of households keeping livestock (n = 51). The questionnaire was related to the potential risk factors and the presence of clinical signs of TB both in animals and humans. Comparative Intradermal Tuberculin Test was conducted to determine the TB status in cattle (n = 393). The overall apparent individual animal prevalence of tuberculin reactors was 3.6% (CI: 95%, 1.9-5.9), whereas the individual true prevalence was estimated at 0.8% (CI: 95%, 0.0-5.0). Using a multivariate logistic regression analysis and a classification tree analysis, the only household level risk factor that significantly influenced the presence of BTB in cattle was the presence of animals coughing in the herd (OR = 4.7, 95% CI: 1.12-19.71, p-value = 0.034). The lack of the practice of quarantine was borderline significant (OR = 4.2, 95% CI: 0.96-18.40, p-value = 0.056). CONCLUSION/SIGNIFICANCE: The study confirmed that BTB is endemic in cattle in Torodi and the risk of the transmission of the disease to humans is potentially high. For the control of the disease in livestock, slaughtering of infected animals and the compensation of the owners is needed. Collaboration between the veterinary and the medical sectors, in the diagnosis, monitoring, prevention and control of BTB is strongly encouraged. [less ▲]

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See detailBovine Vectocardiography: A Comparative Study Relative to the Validity of Four Tridimensional Lead Systems
Amory, Hélène ULiege; Rollin, Frédéric ULiege; Genicot, B. et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1992), 39(6), 453-469

For spatial vectocardiography to become applicable for cardiac investigation in cattle, it was necessary to develop a reliable standardized electrocardiographic lead system in this species. In this study ... [more ▼]

For spatial vectocardiography to become applicable for cardiac investigation in cattle, it was necessary to develop a reliable standardized electrocardiographic lead system in this species. In this study, four tridimensional lead systems, initially developed in horses, were compared when applied in calves. Fifty seven electrocardiograms were collected. The between-subject variability of the magnitude and angles of the tridimensional P, QRS and T modal vectors obtained by use of each lead system was compared. Reproducibility of vectrocardiographic measurements was analyzed by comparing results obtained in 10 calves within a one day interval. The Holmes semi-orthogonal lead system, giving the lowest between-subject variability and the highest between-day reproducibility, appeared to be the most reliable lead system in order to apply vectocardiography in the bovine species. [less ▲]

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See detailLes bovins : en faut-il encore dans nos prairies et nos assiettes ?
Beckers, Yves ULiege

Conference given outside the academic context (2017)

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See detailBovne herpes virus vaccine
Vanderplasschen, Alain ULiege; Thirion, Muriel ULiege

Patent (2011)

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See detailBox C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain.
Verheggen, C.; Mouaikel, J.; Thiry, Marc ULiege et al

in EMBO Journal (2001), 20(19), 5480-90

Nucleolar localization of box C/D small nucleolar (sno) RNAs requires the box C/D motif and, in vertebrates, involves transit through Cajal bodies (CB). We report that in yeast, overexpression of a box C ... [more ▼]

Nucleolar localization of box C/D small nucleolar (sno) RNAs requires the box C/D motif and, in vertebrates, involves transit through Cajal bodies (CB). We report that in yeast, overexpression of a box C/D reporter leads to a block in the localization pathway with snoRNA accumulation in a specific sub-nucleolar structure, the nucleolar body (NB). The human survival of motor neuron protein (SMN), a marker of gems/CB, specifically localizes to the NB when expressed in yeast, supporting similarities between these structures. Box C/D snoRNA accumulation in the NB was decreased by mutation of Srp40 and increased by mutation of Nsr1p, two related nucleolar proteins that are homologous to human Nopp140 and nucleolin, respectively. Box C/D snoRNAs also failed to accumulate in the NB, and became delocalized to the nucleoplasm, upon depletion of any of the core snoRNP proteins, Nop1p/fibrillarin, Snu13p, Nop56p and Nop5p/Nop58p. We conclude that snoRNP assembly occurs either in the nucleoplasm, or during transit of snoRNAs through the NB, followed by routing of the complete snoRNP to functional sites of ribosome synthesis. [less ▲]

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See detailUn box des accusés enfants admis ? Les mineurs et la Cour d'assises
Fierens, Jacques ULiege

in Journal du Droit des Jeunes (2008), 277

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See detailBox search for the data mining of the key parameters of an industrial process
Louveaux, Quentin ULiege; Mathei, Axel; Mathieu, Sébastien ULiege

in Intelligent Data Analysis (2016), 20(6),

To increase their competitiveness, many industrial companies monitor their production process, collecting large amount of measurements. This paper describes a technique using this data to improve the ... [more ▼]

To increase their competitiveness, many industrial companies monitor their production process, collecting large amount of measurements. This paper describes a technique using this data to improve the performance of a monitored process. In particular we wish to find a set of rules, i.e. intervals on a reduced number of parameters, for which an output value is maximized. The model-free optimization problem to solve is to find a box, restricted on a limited amount of dimensions, with the maximum mean value of the included points. This article compares a machine learning-based heuristic to the solution computed by a mixed-integer linear program on real-life databases from steel and glass manufacturing. Computational results show that the heuristic obtains comparable solutions to the mixed integer linear approach. However, the exact approach is computationally too expensive to tackle real life databases. Results show that the restriction of five process parameters, on these databases, may improve the quality of the process by 50%. [less ▲]

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See detailA Box-Behnken Design For Predicting The Combined Effects Of Relative Humidity And Temperature On Antagonistic Yeast Population Density At The Surface Of Apples
Lahlali, Rachid; Massart, Sébastien ULiege; Serrhini, Mn. et al

in International Journal of Food Microbiology (2008), 122(1-2), 100-108

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See detailBox-Flux model of carbon in the Posidonia oceanica seagrass bed of Calvi Bay.
Dauby, Patrick ULiege; Bouquegneau, Jean-Marie ULiege; Soullard, Mady et al

Conference (1993, January)

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See detailBP reduction, organ protection and CV risk : what's new?
Krzesinski, Jean-Marie ULiege

in Journal de Cardiologie = Tijdschrift voor Cardiologie (2009), 21(5), 257-262

Résumé et commentaires à propos d’un symposium satellite organisé lors du 19 ème congrès de l’European Society of Hypertension tenu à Milan en juin 2009. L’HTA est un facteur majeur de risque ... [more ▼]

Résumé et commentaires à propos d’un symposium satellite organisé lors du 19 ème congrès de l’European Society of Hypertension tenu à Milan en juin 2009. L’HTA est un facteur majeur de risque cardiovasculaire. Sa détection doit être validée. Une fois définie, il faut évaluer le risque cardiovasculaire de l’hypertendu. Le contrôle de l’hypertension artérielle mérite une meilleure attention et plus d’initiatives de la part du médecin. Le traitement passe par une approche multifactorielle où les règles hygiénodiététiques sont capitales. Si nécessaire, il faut ajouter des médicaments en choisissant ceux qui sont efficaces et bien tolérés pour un traitement au long cours. Les associations ‘bloqueurs du système rénine-angiotensine et antagoniste calcique’ constituent une nouvelle approche efficace et métaboliquement plus favorable que celles où les diurétiques sont associés à ces bloqueurs de l’axe rénineangiotensine. L’association énalapril – lercanidipine offre des perspectives fort intéressantes notamment dans le haut risque cardiovasculaire pour une efficacité et une adhérence au traitement excellentes. [less ▲]

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See detailbPAG PROFILES IN RECIPIENT HEIFERS AFTER TRANSFER OF IVF AND NUCLEAR TRANSFER EMBRYOS
Ectors, Fabien ULiege; Schmidt, Mette; Smith, Lawrence et al

in Theriogenology (1996, January 01), 45(1), 283

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See detailBPCO et inflammation : mise au point d'un groupe d'experts. Comment traiter l'inflammation ?
Roche, N.; Devillier, P.; Aguilaniu, B. et al

in Revue des Maladies Respiratoires (2011), 28(4), 427-42

INTRODUCTION: Management of chronic obstructive pulmonary disease (COPD) has made considerable progress over the last 15 years, with the development of pulmonary rehabilitation, new molecules to ... [more ▼]

INTRODUCTION: Management of chronic obstructive pulmonary disease (COPD) has made considerable progress over the last 15 years, with the development of pulmonary rehabilitation, new molecules to facilitate smoking cessation, and several medical treatments. Many therapeutic needs, however, remain to be met. STATE OF THE ART: Several lines of research on inflammation and COPD are promising, and some will probably result in new treatments. These may target specific populations, identified by clinical phenotype or by biomarkers. The forthcoming arrival of iPDE-4s on the market illustrates how knowledge of inflammation and remodeling and of some of the underlying mechanisms finally, after many years' development, has broadened the range of treatments available to help improve patients' daily life and outcomes. PERSPECTIVES AND CONCLUSIONS: The availability of such treatments, however, does not mean that knowledge of the disease in the general population and among healthcare workers can be neglected. Early detection (at a stage when treatment can already be effective) and patient education which promotes therapeutic compliance and lasting lifestyle change need to be developed further. [less ▲]

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See detailBPCO et inflammation: mise au point d'un groupe d'experts. Les mecanismes de l'inflammation et du remodelage.
Aubier, M.; Marthan, R.; Berger, P. et al

in Revue des Maladies Respiratoires (2010), 27(10), 1254-1266

The present study reviews the literature on inflammation and remodelling mechanisms in chronic obstructive pulmonary disease (COPD). The development of COPD is associated with chronic pulmonary ... [more ▼]

The present study reviews the literature on inflammation and remodelling mechanisms in chronic obstructive pulmonary disease (COPD). The development of COPD is associated with chronic pulmonary inflammation. Immunity (innate or adaptive) plays a role in its onset and continuation. Airways inflammation alters bronchial structure/function relations: increased bronchial wall thickness, increased bronchial smooth muscle tone, seromucosal gland hypersecretion and loss of elastic structures. Circulating markers of pulmonary inflammation indicate its systemic dissemination. Oxidative stress plays a major role in the onset and persistence of tissue abnormalities. The determinants of extra- and intra-cellular redox control are only partially known. Susceptibility genes, antioxidant system insufficiency and reduced levels of anti-age molecules and of histone deacetylation are also involved. The molecular and cellular targets of inflammation and remodelling are numerous and complex. Currently, tools exist to limit inflammation in COPD but not to act on structural remodelling. [less ▲]

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