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See detailThe 0.8-4.5 μm broadband transmission spectra of TRAPPIST-1 planets
Ducrot, Elsa ULiege; Sestovic, M.; Morris, B. M. et al

in Astronomical Journal (2018), 156

The TRAPPIST-1 planetary system represents an exceptional opportunity for the atmospheric characterization of temperate terrestrial exoplanets with the upcoming James Webb Space Telescope (JWST ... [more ▼]

The TRAPPIST-1 planetary system represents an exceptional opportunity for the atmospheric characterization of temperate terrestrial exoplanets with the upcoming James Webb Space Telescope (JWST). Assessing the potential impact of stellar contamination on the planets' transit transmission spectra is an essential precursor step to this characterization. Planetary transits themselves can be used to scan the stellar photosphere and to constrain its heterogeneity through transit depth variations in time and wavelength. In this context, we present our analysis of 169 transits observed in the optical from space with K2 and from the ground with the SPECULOOS and Liverpool telescopes. Combining our measured transit depths with literature results gathered in the mid/near-IR with Spitzer/IRAC and HST/WFC3, we construct the broadband transmission spectra of the TRAPPIST-1 planets over the 0.8-4.5 $\mu$m spectral range. While planets b, d, and f spectra show some structures at the 200-300ppm level, the four others are globally flat. Even if we cannot discard their instrumental origins, two scenarios seem to be favored by the data: a stellar photosphere dominated by a few high-latitude giant (cold) spots, or, alternatively, by a few small and hot (3500-4000K) faculae. In both cases, the stellar contamination of the transit transmission spectra is expected to be less dramatic than predicted in recent papers. Nevertheless, based on our results, stellar contamination can still be of comparable or greater order than planetary atmospheric signals at certain wavelengths. Understanding and correcting the effects of stellar heterogeneity therefore appears essential to prepare the exploration of TRAPPIST-1's with JWST. [less ▲]

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See detail0681. Effects of veno-venous co2 removal therapy on pulmonary circulation in an ARDS model
MORIMONT, Philippe ULiege; Desaive, Thomas ULiege; TCHANA-SATO, Vincent ULiege et al

in Intensive Care Medicine Experimental (2014, December), 2(S1), 45

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See detail1 Product Service System: a Vector of Consumer Practice Changes Towards More Sustainability
Muylaert, Coralie ULiege; Ruwet, Coline; Maréchal, Kevin ULiege

Conference (2019, June 21)

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See detail1 PSYAPP 2021 Formation CEPES
Leclercq, Dieudonné ULiege

Learning material (2021)

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See detail(1)H, (13)C and (15)N assignments of a camelid nanobody directed against human alpha-synuclein.
Vuchelen, Anneleen; O'Day, Elizabeth; De Genst, Erwin et al

in Biomolecular NMR Assignments (2009), 3(2), 231-3

Nanobodies are single chain antibodies that are uniquely produced in Camelidae, e.g. camels and llamas. They have the desirable features of small sizes (Mw < 14 kDa) and high affinities against antigens ... [more ▼]

Nanobodies are single chain antibodies that are uniquely produced in Camelidae, e.g. camels and llamas. They have the desirable features of small sizes (Mw < 14 kDa) and high affinities against antigens (Kd approximately nM), making them ideal as structural probes for biomedically relevant motifs both in vitro and in vivo. We have previously shown that nanobody binding to amyloidogenic human lysozyme variants can effectively inhibit their aggregation, the process that is at the origin of systemic amyloid disease. Here we report the NMR assignments of a new nanobody, termed NbSyn2, which recognises the C-terminus of the intrinsically disordered protein, human alpha-synuclein (aS), whose aberrant self-association is implicated in Parkinson's disease. [less ▲]

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See detail1, 2, 3 façons d’évaluer des travaux pratiques d’Histologie
Multon, Sylvie ULiege; Crahay, Vinciane ULiege; Florquin, Sandra et al

Conference (2015, January)

Detailed reference viewed: 452 (58 ULiège)
See detail1,2,4-Benzothiadiazine derivatives, their preparation and use
Pirotte, Bernard ULiege; Lebrun, P.; De Tullio, Pascal ULiege et al

Patent (1997)

Detailed reference viewed: 392 (11 ULiège)
See detail1,2,4-Benzothiadiazine derivatives, their preparation and use
De Tullio, Pascal ULiege; Nielsen, F. E.; Hansen, J. B. et al

Patent (1999)

Detailed reference viewed: 334 (8 ULiège)
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See detail1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases
Sevaille, Laurent; Gavara, Laurent; Bebrone, Carine et al

in ChemMedChem (2017), 12

Metallo-β-lactamases (MBLs) cause resistance of Gram-negative bacteria to β-lactam antibiotics and are of serious concern, because they can inactivate the last-resort carbapenems and because MBL ... [more ▼]

Metallo-β-lactamases (MBLs) cause resistance of Gram-negative bacteria to β-lactam antibiotics and are of serious concern, because they can inactivate the last-resort carbapenems and because MBL inhibitors of clinical value are still lacking. We previously identified the original binding mode of 4-amino-2,4-dihydro-5-(2-methylphenyl)-3H-1,2,4-triazole-3-thione (compound IIIA) within the dizinc active site of the L1 MBL. Herein we present the crystallographic structure of a complex of L1 with the corresponding non-amino compound IIIB (1,2-dihydro-5-(2-methylphenyl)-3H-1,2,4-triazole-3-thione). Unexpectedly, the binding mode of IIIB was similar but reverse to that of IIIA. The 3 D structures suggested that the triazole-thione scaffold was suitable to bind to the catalytic site of dizinc metalloenzymes. On the basis of these results, we synthesized 54 analogues of IIIA or IIIB. Nineteen showed IC50 values in the micromolar range toward at least one of five representative MBLs (i.e., L1, VIM-4, VIM-2, NDM-1, and IMP-1). Five of these exhibited a significant inhibition of at least four enzymes, including NDM-1, VIM-2, and IMP-1. Active compounds mainly featured either halogen or bulky bicyclic aryl substituents. Finally, some compounds were also tested on several microbial dinuclear zinc-dependent hydrolases belonging to the MBL-fold superfamily (i.e., endonucleases and glyoxalase II) to explore their activity toward structurally similar but functionally distinct enzymes. Whereas the bacterial tRNases were not inhibited, the best IC50 values toward plasmodial glyoxalase II were in the 10 μm range. [less ▲]

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See detail1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity
Legru, Alice; Verdirosa, Federica; Hernandez, Jean-François et al

in European Journal of Medicinal Chemistry (2021), 226

Metallo-β-lactamases (MBLs) are important contributors of Gram-negative bacteria resistance to β-lactam antibiotics. MBLs are highly worrying because of their carbapenemase activity, their rapid spread in ... [more ▼]

Metallo-β-lactamases (MBLs) are important contributors of Gram-negative bacteria resistance to β-lactam antibiotics. MBLs are highly worrying because of their carbapenemase activity, their rapid spread in major human opportunistic pathogens while no clinically useful inhibitor is available yet. In this context, we are exploring the potential of compounds based on the 1,2,4-triazole-3-thione scaffold as an original ligand of the di-zinc active sites of MBLs, and diversely substituted at its positions 4 and 5. Here, we present a new series of compounds substituted at the 4-position by a thioether-containing alkyl chain with a carboxylic and/or an aryl group at its extremity. Several compounds showed broad-spectrum inhibition with Ki values in the μM to sub-μM range against VIM-type enzymes, NDM-1 and IMP-1. The presence of the sulfur and of the aryl group was important for the inhibitory activity and the binding mode of a few compounds in VIM-2 was revealed by X-ray crystallography. Importantly, in vitro antibacterial susceptibility assays showed that several inhibitors were able to potentiate the activity of meropenem on Klebsiella pneumoniae clinical isolates producing VIM-1 or VIM-4, with a potentiation effect of up to 16-fold. Finally, a selected compound was found to only moderately inhibit the di-zinc human glyoxalase II, and several showed no or only moderate toxicity toward several human cells, thus favourably completing a promising behaviour. [less ▲]

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See detail1,6-AnhMurNAc derivatives for assay development of amidase AmiD.
Mercier, Frédéric ULiege; Zervosen, Astrid ULiege; Teller, Nathalie et al

in Bioorganic and Medicinal Chemistry (2010), 18(21), 7422-31

Various peptidoglycan fragments were synthesized from two anhydro-muramic acid derivatives protected with a Bn or a PMB group at the 4th position, in homogenate phase or on a solid support. In order to ... [more ▼]

Various peptidoglycan fragments were synthesized from two anhydro-muramic acid derivatives protected with a Bn or a PMB group at the 4th position, in homogenate phase or on a solid support. In order to facilitate HPLC detection, a chromophoric group was attached to the peptide chain. The periplasmic amidase sAmiD of Escherichia coli was used to cleave the amide bond between the lactyl group of the MurNAc and the alpha-amino group of L-Ala where the peptide chain was at least a dipeptide (L-Ala-gamma-D-Glu) amidated by benzylamine on the gamma-carboxyl group of D-Glu. In the presence of a tripeptide chain (L-Ala-gamma-D-Glu-L-Lys) or a tetrapeptide chain (L-Ala-gamma-D-Glu-m-A(2)pm-D-Ala) higher hydrolysis rates were observed. We have also demonstrated that the presence of TNB on the epsilon-amino group of L-Lys only has a small influence on the hydrolysis capacity of sAmiD. [less ▲]

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See detail[1-11C]Bromoethane: an alternative to the use of [1-11C]iodoethane.
Schmitz, F.; Del Fiore, G.; Plenevaux, Alain ULiege et al

in Journal of Labelled Compounds and Radiopharmaceuticals (1995), 37

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See detail1-84 PTH and KDIGO Guidelines
CAVALIER, Etienne ULiege

Conference (2012, April 18)

Detailed reference viewed: 388 (7 ULiège)