References of "Osteoarthritis and Cartilage"
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See detailSyndecan-4 is increased in osteoarthritic knee, but nor ip or shoulder, articular hypertrophic chondrocytes
Sanchez, Christelle ULiege; Lambert, Cécile ULiege; Dubuc, Jean-Emile et al

in Osteoarthritis and Cartilage (2019, April), 27(Suppl 1), 159-160

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See detailChondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis
Sanchez, Christelle ULiege; Bay-Jensen, Anne-Christine; Pap, Thomas et al

in Osteoarthritis and Cartilage (2017), 25

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See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULiege; Centonze, Prescilia ULiege; Comblain, Fanny ULiege et al

in Osteoarthritis and Cartilage (2017, April), 25

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan con- tent, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan con- tent, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histo- logical lesions with the mechanical properties of cartilage. [less ▲]

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See detailAn innovative non-animal chitosan hydrogel is able to restore the rheology of osteoarthritis synovial fluid ex vivo
Henrotin, Yves ULiege; Rocasalbas, Guillem; Chausson, Mickaël et al

in Osteoarthritis and Cartilage (2017, April)

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See detailDecision algorithms for the re-treatment with viscosupplementation in patients suffering from knee osteoarthritis
Henrotin, Yves ULiege; Richette, Pascal; Raman, R et al

in Osteoarthritis and Cartilage (2017), 25

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See detailRelationship bewteen weight loss in obese knee osteoarthritis patients and serum biomarkers of cartilage breakdown: Secondary analyses of a randomised trial
Bartels, E; Henrotin, Yves ULiege; Bliddal, H et al

in Osteoarthritis and Cartilage (2017), 25

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See detailRelationship between weight loss in obese knee osteoarthritis patients and serum biomarkers of cartilage breakdown: secondary analyses of a randomised trial
Bartels, E. M.; Henrotin, Yves ULiege; Bliddal, H. et al

in Osteoarthritis and Cartilage (2017), 25(10), 1641-1646

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See detailA machine learning approach for the identification of new biomarkers for knee osteoarthritis development in overweight and obese women
Lazzarini, N.; Runhaar, J.; Bay-Jensen, A. C. et al

in Osteoarthritis and Cartilage (2017), 25(12), 2014-2021

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See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULiege; Lambert, Cécile ULiege; Comblain, Fanny ULiege et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 88

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See detailOsteoarthritic sclerotic subchondral osteoblasts secreted elevated concentration of fibulin-3 fragments in vitro
Sanchez, Christelle ULiege; Lambert, Cécile ULiege; Comblain, Fanny ULiege et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 83

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See detailFibulin-3 fragments are prognostic biomarkers of osteoarthritis incidence in overweight and obese women
Runhaar, Jos; Sanchez, Christelle ULiege; Taralla, Sébastien et al

in Osteoarthritis and Cartilage (2016), 24(4), 672-678

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg ... [more ▼]

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg/m2, free of knee OA, were recruited. Using binary logistic regression, the association between baseline concentration of serum fibulin (Fib)3-1, Fib3-2 and Fib3-3 and incidence of clinical and radiographic knee OA after 30 months of follow-up was evaluated. RESULTS: Baseline and follow-up measurements were available for 241 women with a mean age of 55.9 +/- 3.2 years and mean BMI of 31.7 +/- 3.6 kg/m2. None of the concentrations of the three Fib3 epitopes were associated with the incidence of medial or lateral joint space narrowing (JSN) >/=1.0 mm or the incidence of Kellgren & Lawrence (K&L) grade >/=2 after 30 months. All three Fib3 epitopes were associated with the incidence of the clinical and radiographic ACR-criteria and Fib3-1 and Fib3-3 also with chronic pain at follow-up. When adjusted for the other Fib3 peptide concentrations, only Fib3-1 was significantly associated to the incidence of the American College of Rheumatology (ACR)-criteria (OR 3.2 [1.2-8.7]) and chronic pain at follow-up (OR 3.0 [1.2-7.7]). CONCLUSIONS: Baseline fibulin-3 concentrations are associated with the incidence of clinical knee OA among middle-aged overweight and obese women. Therewith, they meet the criteria of a prognostic biomarker according to the BIPED biomarker classification for OA. Further validation of the fibulin-3 epitopes seems warranted in order to better distinguish subgroups of individuals at increased risk for knee OA development. [less ▲]

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See detailIdentification of a Spectrum of Therapeutic Targets of a New Treatment for Osteoarthritis Composed by Curcuminoids Extract, Hydrolyzed Collagen and Green Tea Extract
Comblain, Fanny ULiege; Dubuc, Jean-Emile; Lambert, Cécile ULiege et al

in Osteoarthritis and Cartilage (2016, April), 24(Supp 1), 353

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See detailOsteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria.
Bay-Jensen, A. C.; Reker, D.; Kjelgaard-Petersen, C. F. et al

in Osteoarthritis and Cartilage (2016), 24(1), 9-20

OBJECTIVE: To review and summarize biomarker data published from April 2014 to May 2015 to provide insight to the ongoing work in the field of osteoarthritis (OA). Furthermore, to summarize the BIPED ... [more ▼]

OBJECTIVE: To review and summarize biomarker data published from April 2014 to May 2015 to provide insight to the ongoing work in the field of osteoarthritis (OA). Furthermore, to summarize the BIPED criteria and set it in context of the medical needs of 2015. METHODS: PubMed was used as searching machine: Time period 2014/04/01-2015/05/01, MeSH term [Biomarker] AND [Osteoarthritis], Language; English, Full text available. Reviews were excluded. Only papers describing protein based biomarkers measured in human body fluids from OA patients were included. RESULTS: Biomarkers of joint tissue turnover, cytokines, chemokines and peptide arrays were measured in different cohorts and studies. Amongst those were previously tested biomarkers such as osteocalcin, Carboxy-terminal cross-linked fragment of type II collagen (CTX-II) and cartilage oligomeric matrix protein (COMP). A majority of the biomarker were classified as I, B or B biomarkers according to the BIPED criteria. Work is continuing on testing biomarkers in OA. There is still a huge, unmet medical need to identify, test, validate and qualify novel and well-known biomarkers. A pre-requisite for this is better characterization and classification of biomarkers to their needs, which may not be reached before higher understanding of OA phenotypes has been gained. In addition, we provide some references to some recent guidelines from Food and Drug Administration (FDA) and European Medicines Agency (EMA) on qualification and usage of biomarkers for drug development and personalized medicine, which may provide value to the field. [less ▲]

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See detailRestriction of spontaneous and prednisolone-induced leptin production to dedifferentiated state in human hip OA chondrocytes: role of Smad1 and b-catenin activation
CHARLIER, Edith ULiege; MALAISE, Olivier ULiege; Zeddou, Mustapha et al

in Osteoarthritis and Cartilage (2016)

Objective: The aetiology of OA is not fully understood although several adipokines such as leptin are known mediators of disease progression. Since leptin levels were increased in synovial fluid compared ... [more ▼]

Objective: The aetiology of OA is not fully understood although several adipokines such as leptin are known mediators of disease progression. Since leptin levels were increased in synovial fluid compared to serum in OA patients, it was suggested that joint cells themselves could produce leptin. However, exact mechanisms underlying leptin production by chondrocytes are poorly understood. Nevertheless, prednisolone, although displaying powerful anti-inflammatory properties has been recently reported to be potent stimulator of leptin and its receptor in OA synovial fibroblasts. Therefore, we investigated, in vitro, spontaneous and prednisolone-induced leptin production in OA chondrocytes, focusing on transforming growth factor-b (TGFb) and Wnt/b-catenin pathways. Design: We used an in vitro dedifferentiation model, comparing human freshly isolated hip OA chondrocytes cultivated in monolayer during 1 day (type II, COL2A1 þ; type X, COL10A1 þ and type I collagen, COL1A1 ") or 14 days (COL2A1 "; COL10A1 " and COL1A1þ). Results: Leptin expression was not detected in day1 OA chondrocytes whereas day14 OA chondrocytes produced leptin, significantly increased with prednisolone. Activin receptor-like kinase 1 (ALK1)/ALK5 ratio was shifted during dedifferentiation, from high ALK5 and phospho (p)-Smad2 expression at day1 to high ALK1, endoglin and p-Smad1/5 expression at day14. Moreover, inactive glycogen synthase kinase 3 (GSK3) and active b-catenin were only found in dedifferentiated OA chondrocytes. Smad1 and b-catenin but not endoglin stable lentiviral silencing led to a significant decrease in leptin production by dedifferentiated OA chondrocytes. Conclusions: Only dedifferentiated OA chondrocytes produced leptin. Prednisolone markedly enhanced leptin production, which involved Smad1 and b-catenin activation [less ▲]

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See detailFinite element modeling of proximal tibial stiffness in normal and osteoarthritic knees: in vivo precision and preliminary comparisons
Arjmand, Hanieh; Nazemi, Sayed Majid ULiege; Kontulainen, Saija A. et al

in Osteoarthritis and Cartilage (2016)

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