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See detailSarcopenia and health-related outcomes: an umbrella review of observational studies
Veronese, N.; Demurtas, J.; Soysal, P. et al

in European Geriatric Medicine (2019), 10(6), 853-862

Background: The clinical relevance of sarcopenia has increasingly been recognized. However, whether it is associated with the development of other medical conditions is still unclear. Therefore, we aimed ... [more ▼]

Background: The clinical relevance of sarcopenia has increasingly been recognized. However, whether it is associated with the development of other medical conditions is still unclear. Therefore, we aimed to capture the scale of outcomes that have been associated with the presence of sarcopenia and systematically assess the quality, strength, and credibility of these associations using an umbrella review methodology. Methods: A systematic review in several databases was carried out, until 20th February 2019. For each association, random-effects summary effect size, 95% confidence intervals (CIs), heterogeneity (I 2), evidence for small-study effect, evidence for excess significance bias, and 95%-prediction intervals were estimated. We used these metrics to categorize the evidence of significant outcomes (p < 0.05) from class I (convincing) to class IV (weak), according to pre-established criteria. Results: From 358 abstracts, 6 meta-analyses with 14 associations were included. Sarcopenia was associated with higher risk of other comorbidities and mortality in 11 of 14 outcomes explored. However, only 3 outcomes (i.e., association between sarcopenia and increased risk of death in community-dwelling older people [odds ratio, OR = 3.60; 95% CI 2.96–4.37; n = 14,305], disability [OR = 3.04; 95% CI 1.80–5.12; n = 8569], and falls [OR = 1.60; 95% CI 1.31–1.97; n = 12,261]) presented a highly suggestive evidence (class II). Other association was classified as having only a weak evidence. Conclusion: Sarcopenia is associated with several adverse health-related outcomes in older people, and its associations with mortality, disability, and falls are supported by a highly suggestive evidence. The effect of interventions on sarcopenia to improve these outcomes needs to be investigated. © 2019, © 2019, European Geriatric Medicine Society. [less ▲]

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See detailValidation of the Lithuanian version of sarcopenia‑specific quality of life questionnaire (SarQoL®)
Alekna, Vidmantas; Kilaite, Justina; Tamulaitiene, Marija et al

in European Geriatric Medicine (2019), 10

Aim To translate and culturally adapt the SarQoL® questionnaire into Lithuanian language and investigate its main psychometric properties. Findings The total score of the SarQoL® questionnaire was ... [more ▼]

Aim To translate and culturally adapt the SarQoL® questionnaire into Lithuanian language and investigate its main psychometric properties. Findings The total score of the SarQoL® questionnaire was significantly lower for sarcopenic subjects compared to nonsarcopenic subjects. Cronbach’s alpha coefficient was 0.95. The SarQoL ® questionnaire revealed good construct validity and test–retest reliability. Message Lithuanian version of the SarQoL® can be used to assess quality of life in sarcopenic population. [less ▲]

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See detailElderly and technologies: between myths and reality
Piccard, Sébastien ULiege; Pagacz, Pierre ULiege; Boulanger, Christelle et al

in European Geriatric Medicine (2018, October), 2018(9 (supp 1)),

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See detailTechnology and aging : new opportunities for a better life
PETERMANS, Jean ULiege; Piccard, Sébastien ULiege; Boulanger, G

in European Geriatric Medicine (2018, October), 9(supp1),

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See detailAssociation between urinary incontinence and frailty: a systematic review and meta-analysis
Veronese, N.; Soysal, P.; Stubbs, B. et al

in European Geriatric Medicine (2018), 9(5), 571-578

Purpose: Urinary incontinence (UI) and frailty are common geriatric syndromes. Although literature increasingly supports a relationship between these two conditions, no systematic review and meta-analysis ... [more ▼]

Purpose: Urinary incontinence (UI) and frailty are common geriatric syndromes. Although literature increasingly supports a relationship between these two conditions, no systematic review and meta-analysis has been performed on this topic. Therefore, we aimed to investigate the potential association between UI and frailty, through a meta-analytic approach. Methods: A systematic search in major databases was undertaken until 15th March 2018 for studies reporting the association between UI and frailty. The prevalence of UI in people with frailty (vs. those without) was pooled through an odds ratio (OR) and 95% confidence intervals (CIs), with a random-effects model. The other outcomes were summarized descriptively. Results: Among 828 papers, 11 articles were eligible, including 3784 participants (mean age 78.2 years; 55.1% women). The prevalence of UI was 39.1% in people with frailty and 19.4% in those without. A meta-analysis with five studies (1540 participants) demonstrated that UI was over twice as likely in frail people versus those without (OR 2.28; 95% CI 1.35–3.86; I2 = 61%). One cross-sectional study, adjusting for potential confounders and one longitudinal study confirmed that UI is significantly associated with frailty. In two cross-sectional studies, using adjusted analyses, frailty was more common in people with UI. Conclusion: Urinary incontinence is twice as common in older people with frailty compared to older people without frailty. Screening and the development of interventions for UI and frailty could prove useful for this common comorbidity. © 2018, European Geriatric Medicine Society. [less ▲]

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See detailAssessing gait parameters with accelerometer-based methods to identify older adults at risk of falls: a systematic review
GILLAIN, Sophie ULiege; Boutaayamou, Mohamed ULiege; Beaudart, Charlotte ULiege et al

in European Geriatric Medicine (2018), 9

Purpose The purpose of this study was to perform a systematic review to assess the utility of accelerometric methods to identify older adults at risk of falls. Methods The Preferred Reporting Item for ... [more ▼]

Purpose The purpose of this study was to perform a systematic review to assess the utility of accelerometric methods to identify older adults at risk of falls. Methods The Preferred Reporting Item for Systematic review and Meta-Analysis (PRISMA) guidelines were followed during all steps of this systematic review. Cross sectional and longitudinal studies assessing gait parameters in older adults using accelerometric devices, and comparing groups based on the risk of falls or fall history were identified from studies published in the MEDLINE, SCOPUS and Cochrane Database of Systematic Reviews databases between January 1996 and January 2017. Study selection and data extraction were performed independently by two reviewers. The quality of the methodology used in the studies included was assessed using the Newcastle–Ottawa Scale. Results In total, 354 references were identified through the database search. After selection, ten studies were included in this systematic review. According to the cross sectional studies, people who fall or are at risk of fall are slower, and walk with shorter steps, lower step frequency, worse stride and step regularity in terms of time, position and acceleration profiles. One longitudinal study suggests considering harmonic ratio of upper trunk acceleration in the vertical plane. Two other longitudinal studies highlight the importance of considering more than one gait parameter, and sophisticated statistical tools to discern older adults at risk for future fall(s). Conclusion This systematic review essentially highlights the lack of available literature providing strong evidence that gait parameters obtained using acceleration-based methods could be useful to discern older people at risk of fall. Available literature is encouraging, but further high quality studies are needed to highlight the cross-sectional and longitudinal relationships between gait parameters and falls in older adults. [less ▲]

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See detailCross-cultural adaptation and validation of the SARC-F to assess sarcopenia: methodological report from European Union Geriatric Medicine Society Sarcopenia Special Interest Group
Bahat, Gulistan; Yilmaz, Ozlem; Merve Oren, Meryem et al

in European Geriatric Medicine (2018), 9

Sarcopenia is a well-identified process of aging known to cause functional deterioration, falls, fractures, frailty and mortality. Considering the global aging population, sarcopenia assessment has become ... [more ▼]

Sarcopenia is a well-identified process of aging known to cause functional deterioration, falls, fractures, frailty and mortality. Considering the global aging population, sarcopenia assessment has become a public health priority because its early detection is expected to prevent or decrease adverse outcomes through commencement of therapeutic measures. Therefore, the diagnosis of sarcopenia mediated by effective screening is expected to become particularly important. Being very practical with clearly demonstrated value to predict sarcopenia-related adverse outcomes, SARC-F questionnaire stands as one of the best tools to evaluate sarcopenia in every day practice. SARC-F has originally been created in English. Considering the variety of languages in Europe, it seems very valid to adapt and validate this tool in different European languages. This report is written to explain the details of the final consensus methodology suggested for SARC-F validation, thereby guiding and helping the research teams in their studies. [less ▲]

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See detailThe International Registry of patients with sarcopenia: applying research in sarcopenia to clinical practice
Sanchez Rodriguez, Maria Dolores Carmen ULiege; Bruyère, Olivier ULiege

in European Geriatric Medicine (2018), 9

Sarcopenia has been recently recognized as a disease for the purposes of coding (ICD-10-CM M62.84) and reimbursement [1, 2]. This acknowledgement has important implications for researchers, as this ... [more ▼]

Sarcopenia has been recently recognized as a disease for the purposes of coding (ICD-10-CM M62.84) and reimbursement [1, 2]. This acknowledgement has important implications for researchers, as this disease is related to malnutrition and frailty [3], functional decline, high rate of hospitalization, loss of quality of life [4] and increased mortality [5], but the definitive diagnostic [6] and therapeutic strategies [2] to counteract this reversible condition remain a challenge [7]. The European Geriatric Medicine Society (EuGMS) is a leader in activities around sarcopenia in Europe and promoted the European Working Group on Sarcopenia in Older People (EWGSOP), which has proposed the most widely used algorithm for sarcopenia case finding and recommends assessment of sarcopenia in all geriatric patients and every healthcare setting [7]. The EuGMS founded the Special Interest Group (SIG) on Sarcopenia in September 2015, and published the first special issue on sarcopenia in European Geriatric Medicine in 2016 [8]; since then, the number of formal members of this interest group has increased to 74, making it the most extensive SIG of the EuGMS. [less ▲]

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See detailFrench translation and validation of the sarcopenia screening tool SARC-F
Beaudart, Charlotte ULiege; Locquet, Médéa ULiege; Bornheim, Stephen ULiege et al

in European Geriatric Medicine (2018), 9

Introduction The purpose of the present study is to translate and validate into French the SARC-F questionnaire, a simple and easy screening tool for sarcopenia. Materials and methods The translation ... [more ▼]

Introduction The purpose of the present study is to translate and validate into French the SARC-F questionnaire, a simple and easy screening tool for sarcopenia. Materials and methods The translation process has been divided into two consecutive parts: (1) the translation of the questionnaire from English to French and its language validation (inter-rater reliability and test–retest reliability); (2) the clinical validation of the French SARC-F to assess its performance (sensitivity, specificity, predictive positive value and predictive negative value) in a cohort of elderly Belgian subjects against 7 existing definitions of sarcopenia. Results The translated French version of the SARC-F demonstrated an excellent inter-rater reliability, with an intraclass correlation coefficient (ICC) of 0.90 (95% CI 0.76–0.96), as well as excellent test–retest reliability, with an ICC of 0.86 (95% CI 0.66–0.94). Afterwards, 306 subjects took part in the clinical validation of the French version of the SARC-F questionnaire. The results showed that sensitivity of the tool ranged from 22.1 to 75.0%, depending on the definition used for the diagnosis of sarcopenia, and the specificity ranged from 84.9 to 87.1%. Moreover, all positive predictive values were always below 50%; the lowest negative predictive value was 68.1%, and the best one reached approximately 99%. Conclusions The results are in line with the psychometric performance found in the initial English validation of the SARCF and seem to indicate that this screening tool can detect with precision the absence of sarcopenia, but seems less precise in affirming the presence of this geriatric syndrome. [less ▲]

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See detailSarcopenic osteoarthritis: a new entity in geriatric medicine?
Veronese, N.; Punzi, L.; Sieber, C. et al

in European Geriatric Medicine (2018), 9(2), 141-148

Purpose: Osteoarthritis, a disease characterized by cartilage degradation, abnormal subchondral bone remodeling and some grade of inflammation, and sarcopenia, a condition of low muscle mass associated ... [more ▼]

Purpose: Osteoarthritis, a disease characterized by cartilage degradation, abnormal subchondral bone remodeling and some grade of inflammation, and sarcopenia, a condition of low muscle mass associated with reduced strength and function, are prevalent disorders in older adults. In this review, we examine what is known about the relationship between osteoarthritis and sarcopenia, with particular focus on the older population. We also discuss how osteoarthritis and sarcopenia may interact and affect each other in clinical progression and the potential benefits from developing treatments that address such muscular-skeletal interaction. Methods: We searched in Pubmed and Scopus through a combination of search and MESH terms, for osteoarthritis and sarcopenia. Results: Even if more literature is needed, there is increasing evidence that decline in lower limb muscle strength is associated with knee or hip osteoarthritis in a pathological network of pain, altered joint stability, maladapted postures and defective neuromuscular communication. At the cellular levels, chondrocytes and myoblasts share common pathways, and the close anatomical location of both cell types also suggest the possibility of paracrine communication. Conclusions: Sarcopenia and osteoarthritis are significantly intercorrelated and in the near future should be considered as an only entity, as we have recently proposed for sarcopenia and osteoporosis. The treatment of both sarcopenia and osteoarthritis is based on physical exercise and nutritional interventions with the aim of improving cartilage, bone and muscle health. Future studies are needed, particularly to know the exact prevalence of sarcopenia in people with osteoarthritis, its peculiar consequences and the most appropriate treatments. © 2018, European Geriatric Medicine Society. [less ▲]

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See detailNew horizons in geriatric medicine education and training: The need for pan-European education and training standards
Fischer, JM; Massud, Tahir; ROLLER-WIRNSBERGER, RE et al

in European Geriatric Medicine (2017), 8(5-6), 467-473

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See detailGerontechnology : don't miss the train, but which is the right carriage
PETERMANS, Jean ULiege

in European Geriatric Medicine (2017), 8

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See detailAssessment of muscle mass, muscle strength and physical performance in clinical practice: An international survey
Bruyère, Olivier ULiege; Beaudart, Charlotte ULiege; Reginster, Jean-Yves ULiege et al

in European Geriatric Medicine (2016), 7(3), 243-6

Introduction: Several tools are available for the assessment of muscle mass, muscle strength and physical performance in clinical research. However, few data are available on the usage of these tools in ... [more ▼]

Introduction: Several tools are available for the assessment of muscle mass, muscle strength and physical performance in clinical research. However, few data are available on the usage of these tools in clinical practice. Methods: This study aimed to assess their usage by means of a large online international survey. Since sarcopenia is a specific condition where the assessment of muscle mass, muscle strength and physical performance is important, the survey also assessed the tools used for the diagnosis of this geriatric syndrome. Results: The survey was completed by 255 clinicians from 55 countries across 5 continents. Among these clinicians with geriatrics, rheumatology and endocrinology as major fields of interest, 53.3% assess muscle mass in daily practice, 54.5% muscle strength and 71.4% physical performance. However, the tools used are very different and no single tool is used by all clinicians. The tools and the cut-off values used by clinicians to diagnose sarcopenia are also heterogeneous. Conclusion: Because some tools used for the assessment of muscle mass, muscle strength or physical performance in daily practice are less validated than others, a greater awareness from the clinicians of the importance of using appropriate tools is needed [less ▲]

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See detailCritical analytical evaluation of promising markers for sarcopenia
Cavalier, Etienne ULiege; Beaudart, Charlotte ULiege; Buckinx, Fanny ULiege et al

in European Geriatric Medicine (2016), 7(3), 239-242

We tested and validated irisin (IRI), myostatin (MYO), PIIINP, osteoglycin (OGN), TMEM119 (TMEM) and activin A (AA) and established the analytical performance, reference range and stability (considered ... [more ▼]

We tested and validated irisin (IRI), myostatin (MYO), PIIINP, osteoglycin (OGN), TMEM119 (TMEM) and activin A (AA) and established the analytical performance, reference range and stability (considered unstable if more than 20% increase/decrease in the levels was observed in more than 10% of the samples). We were unable to obtain a valuable calibration curve with the Cusabio kits (TMEME and OGN). Coefficient of variation (CV) was too high for IRI (CV 17-30%), but were ≤ 10% for the 3 other analytes. AA and MYO were stable up to 3 months at -20 °C and -80 °C in serum or EDTA plasma and up to 6 months at -80 8C. PIIINP was stable only 1 month in EDTA plasma (but not in serum) at -20 °C or -80 8C. After 3 months of storage, PIIINP was not stable anymore, in serum or EDTA plasma, at -20 °C or -80 8C. Surprisingly, after 6 months at -80 8C, results returned in the ± 20% for both serum and EDTA plasma. PIIINP levels did not differ between men and women and the RR was (median, 90% CI) 1.2 (0.8-1.6)-6.0 (5.6-6.4) μg/L. The RR for MYO was 845 (437-1312)-6067 (5524-6552) pg/mL for men and 600 (268-1027)-4438 (4026-4837) pg/mL for women and the RR for AA was 177 (132-210)-622 (580-661) pg/mL for men and 98 (49-147)-480 (430-525) pg/mL for women. PIIINP and AA but not MYO accumulated in CKD as values observed in 10 hemodialyzed patients were higher than in normal individuals. © 2015 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved. [less ▲]

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See detailSarcopenia as a public health problem
Bruyère, Olivier ULiege; Beaudart, Charlotte ULiege; Locquet, Médéa ULiege et al

in European Geriatric Medicine (2016), 7(3), 272-5

The importance of a health problem is based on its current and expected prevalence, its clinical and economic consequences, the social status of people affected by the problem and the availability of an ... [more ▼]

The importance of a health problem is based on its current and expected prevalence, its clinical and economic consequences, the social status of people affected by the problem and the availability of an effective treatment. In this paper, we review the main current literature on sarcopenia in order to assess whether this geriatric syndrome could be considered as a major public health problem. Our review highlights that based on its prevalence, its clinical consequences, the limitations of the current available treatments as well as on the fact that many frail patients are affected by this geriatric syndrome, sarcopenia should be considered as a health priority by all interested parties in order to reduce its burden. [less ▲]

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See detailGrip strength measurement: Towards a standardized approach in sarcopenia research and practice
Schaap, L. A.; Fox, B.; Henwood, T. et al

in European Geriatric Medicine (2016), 7(3), 247-255

Introduction: Grip strength is a well-accepted measure of muscle strength. A standardized protocol for the measurement of grip strength has been proposed in 2011 to enable consistent measurement of grip ... [more ▼]

Introduction: Grip strength is a well-accepted measure of muscle strength. A standardized protocol for the measurement of grip strength has been proposed in 2011 to enable consistent measurement of grip strength and comparisons between studies. It is unknown whether this protocol has been adopted in sarcopenia research and practice. The aim of the study was to provide insight into current measurement practice, including the use of cut-off values for low muscle strength. Methods: A systematic review of the literature was conducted, followed by a methodological quality assessment and extraction of relevant data. Inclusion criteria included a description of the grip strength protocol, EWGSOP standards were used to define sarcopenia, data was collected after 2010 and participants were 65 years and older. Results: Twenty-seven observational papers were included in the review. The methodological quality was acceptable/good. Overall, information about the protocol was limited with a large variability in measurement approach. Most non-Asian studies used cut-off values for low grip strength of 30 kg for men and 20 kg for women. Asian studies showed more variability in choice of cut-off values. Discussion: The proposed grip strength measurement protocol has been poorly adopted since its publication. Although there seems to be some agreement on cut-off values in non-Asian studies, proposed cut-off values need to be evaluated in specific diseases and settings and its predictive abilities regarding outcomes such as mobility limitations and falls needs to be determined. Asian research on cut-off values is still ongoing. © 2015 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved. [less ▲]

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See detailThe role of vaccination in successful independent ageing
McElhaney, JE; Gavazzi, G; flamaing, johan et al

in European Geriatric Medicine (2016), 7

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See detailA comprehensive fracture prevention strategy in older adults: The European union geriatric medicine society (EUGMS) statement
Blain, H.; Masud, T.; Dargent-Molina, P. et al

in European Geriatric Medicine (2016), 7(6), 519-525

Prevention of fragility fractures in older people has become a public health priority, although the most appropriate and cost-effective strategy remains unclear. In the present statement, the Interest ... [more ▼]

Prevention of fragility fractures in older people has become a public health priority, although the most appropriate and cost-effective strategy remains unclear. In the present statement, the Interest group on falls and fracture prevention of the European union geriatric medicine society (EUGMS), in collaboration with the International association of gerontology and geriatrics for the European region (IAGG-ER), the European union of medical specialists (EUMS), the Fragility fracture network (FFN), the International osteoporosis foundation (IOF) – European society for clinical and economic aspects of osteoporosis and osteoarthritis (ECCEO), outlines its views on the main points in the current debate in relation to the primary and secondary prevention of falls, the diagnosis and treatment of bone fragility, and the place of combined falls and fracture liaison services for fracture prevention in older people. © 2016 [less ▲]

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See detailQuality of life and physical components linked to sarcopenia: baseline data of the SarcoPhAge study
Beaudart, Charlotte ULiege; Reginster, Jean-Yves ULiege; Petermans, Jean ULiege et al

in European Geriatric Medicine (2015, September), 6S1

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See detailDevelopment and validation of a self-administrated quality of life questionnaire specific to sarcopenia: the SarQol
Beaudart, Charlotte ULiege; Reginster, Jean-Yves ULiege; Rizzoli, R. et al

in European Geriatric Medicine (2015, September), 6S1

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