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See detailThrombin receptor agonist peptide immobilized in microspheres stimulates reparative processes in rats with gastric ulcer
Rusanova, A. V.; Makarova, A. M.; Strukova, S. M. et al

in Bulletin of Experimental Biology and Medicine (2006), 142

The effect of synthetic thrombin receptor (PAR1) agonist peptide encapsulated in microspheres made of lactic and glycolic acid copolymer on tissue reparation was studied in rats with acetate-induced ulcer ... [more ▼]

The effect of synthetic thrombin receptor (PAR1) agonist peptide encapsulated in microspheres made of lactic and glycolic acid copolymer on tissue reparation was studied in rats with acetate-induced ulcer. PAR1 agonist peptide was immobilized in biodegraded lactic and glycolic acid microspheres by double emulgation, the kinetics of peptide release was analyzed, and the dynamics of ulcer healing was studied in experimental (administration of microspheres with the peptide into the stomach) and two control groups (administration of saline or spheres without peptide). Thrombin receptor agonist peptide gradually released from lactic and glycolic acid microspheres into the stomach shortened the inflammation phase and shifted the proliferation phase to the earlier period, thus accelerating healing of experimental ulcers in rats. [less ▲]

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See detailTRAP-6, immobilized in microspheres, accelerates tissue regeneration in gastric ulcer rat model.
Rusanova, A.; Makarova, A.; Strukova, S. et al

in Bulletin of Experimental Biology and Medicine (2006), 142(7), 42-46

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See detailEffect of synthetic peptide thrombin receptor agonist encapsulated in microparticles based on lactic and glycolic acid copolymer on healing of experimental skin wounds in mice.
Dugina, T.N; Kiseleva, E.V; Lange, M.A et al

in Bulletin of Experimental Biology and Medicine (2004), 138(5), 463-466

PAR1 peptide thrombin receptor agonist (PAR1-AP) was encapsulated in microcorpuscles based on lactic and glycolic acid copolymer. The desorption profile of the preparation was studied in vitro and its ... [more ▼]

PAR1 peptide thrombin receptor agonist (PAR1-AP) was encapsulated in microcorpuscles based on lactic and glycolic acid copolymer. The desorption profile of the preparation was studied in vitro and its wound-healing effects were studied on a model of cut skin wound in mice. The study showed that 90% PAR1-AP was desorbed over 6 h, but the peptide was detected in eluates from the microparticle surface after 23 h. The desorbed peptide retained its physiological activity and was capable of activating PAR1 receptors on human platelets. The study of the dynamics of experimental skin wound healing in mice showed lower number of macrophages in the wounds treated with PAR1-AP microparticles compared to the control (open wounds and wounds covered with microparticles) and higher number of fibroblasts on day 3 of tissue reparation. Hence, PAR1-AP desorbed from microparticles shortened the inflammation phase in the wound. On day 7 the best healing parameters were also observed in wounds treated with PAR1-AP microparticles, which attests to shortening of the proliferation phase and acceleration of wound healing. [less ▲]

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See detailEffect of intravessel irradiation of venous blood on fever syndrome in rats
Chichkan, D. N.; Koulchitsky, Stanislav ULiege; Tikhonov, A. V. et al

in Bulletin of Experimental Biology and Medicine (1998), 126(4), 991992

Experiments on wakeful rats revealed that the second phase of hyperthermal response evoked by intraperitoneal administration of endotoxin is eliminated after intravascular irradiation of venous blood in ... [more ▼]

Experiments on wakeful rats revealed that the second phase of hyperthermal response evoked by intraperitoneal administration of endotoxin is eliminated after intravascular irradiation of venous blood in the ultraviolet range during the first phase of experimental fever. [less ▲]

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