References of "Revue Médicale de Liège"
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See detailPharma-clinics comment je traite ... une infection par le VIH. IV. Les inhibiteurs de protease
Leonard, Philippe ULiege; Nkoghe, D.; Moutschen, Michel ULiege et al

in Revue Médicale de Liège (2001), 56(11), 739-44

Protease inhibitors constitute the last class of antiretroviral drugs appeared on the market. They raised an enormous enthusiasm, reinforced by recent studies results. These molecules prevent the ... [more ▼]

Protease inhibitors constitute the last class of antiretroviral drugs appeared on the market. They raised an enormous enthusiasm, reinforced by recent studies results. These molecules prevent the formation of infectious viral particles, while inhibiting a viral enzyme that plays a key role in the cycle of replication of the HIV. Their efficiency, especially in association, is recognized for all stages of the infection and the intervening of a resistance often requires many mutations. However, the unexpected adverse events such as lipodystrophy and some interactions can limit their utilization in first intention. [less ▲]

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See detailL'image du mois. Un melanome masque chez un joueur de tennis
Fraiture, A. L.; Henry, Frédérique ULiege; Pierard-Franchimont, Claudine ULiege et al

in Revue Médicale de Liège (2001), 56(11), 737-8

A man presented with a malignant melanoma of the scalp. The lesion reached a large size before being disclosed. Repetitive sunburns during tennis matches could be responsible for this cancer. Indeed, hair ... [more ▼]

A man presented with a malignant melanoma of the scalp. The lesion reached a large size before being disclosed. Repetitive sunburns during tennis matches could be responsible for this cancer. Indeed, hair protects only partially the skin from ultraviolet damages. [less ▲]

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See detailLa guerre et la medecine d'une culture de paix. 1. Quand s'ouvrent les portes du temple de janus
Pierard, Gérald ULiege

in Revue Médicale de Liège (2001), 56(11), 785-7

More than 40 major wars took place during the past decade. The origins and the warlike means that were engaged were very different from those of older conflicts. Wars between nations are less numerous ... [more ▼]

More than 40 major wars took place during the past decade. The origins and the warlike means that were engaged were very different from those of older conflicts. Wars between nations are less numerous. They have been replaced by civilian wars that are more rooted on cultural and religious grounds than on economic interests alone. During this short period of time, warfare was responsible for about 2 millions of direct deaths and 20 millions displaced people and refugees. The injured and victims of starvation and epidemics were innumerable and awaited for civilian medical help. [less ▲]

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See detailLe deficit en alpha-1 antitrypsine. Une indication de transplantation hepatique pediatrique
De Roover, Arnaud ULiege; Detry, Olivier ULiege; Honore, Pierre ULiege et al

in Revue Médicale de Liège (2001), 56(11), 753-8

Alpha-1-antitrypsin deficiency is the most common inborn error of metabolism leading to liver transplantation, and the second cause of liver transplantation in children after biliary atresia. The authors ... [more ▼]

Alpha-1-antitrypsin deficiency is the most common inborn error of metabolism leading to liver transplantation, and the second cause of liver transplantation in children after biliary atresia. The authors report the case of a 6-year-old girl, who was suffering from end-stage liver disease secondary to alpha-1-antitrypsin deficiency. She was successfully treated by whole liver transplantation, the hepatic graft coming from a 3-year-old donor. Three months later she went back to school. The authors discuss the pathogenesis and the natural history of this frequent cause of liver transplantation in children. [less ▲]

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See detailLe cas clinique du mois. Epidermolyse staphylococcique aigue chez une quinquagenaire
Fumal, I.; Paquet, Philippe ULiege; JACOB, ERIC et al

in Revue Médicale de Liège (2001), 56(11), 745-747

Staphylococcal scalded skin syndrome is a bullous disease induced by bacterial exfoliative exotoxins. Children are most often affected. The prognosis is worse in adults and calls for treatment in an ... [more ▼]

Staphylococcal scalded skin syndrome is a bullous disease induced by bacterial exfoliative exotoxins. Children are most often affected. The prognosis is worse in adults and calls for treatment in an intensive care unit. We report a case in a quinquagenerian woman who suffered from angina a few days before the bullous erythroderma. [less ▲]

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See detailEffets indesirables cutanes des interferons
Paquet, Philippe ULiege; Pierard-Franchimont, Claudine ULiege; Arrese, J. E. et al

in Revue Médicale de Liège (2001), 56(10), 699-702

The alpha, beta and gamma recombinant interferons are indicated in a growing spectrum of therapeutic indications. Some unwanted side effects occur on the skin. The main clinical presentations include ... [more ▼]

The alpha, beta and gamma recombinant interferons are indicated in a growing spectrum of therapeutic indications. Some unwanted side effects occur on the skin. The main clinical presentations include vesiculo-bullous sometimes infiltrated dermatitis, vasculitis, necrosis, ulceration and alopecia. Exacerbation of dermatoses such as psoriasis is also possible. [less ▲]

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See detailAnthrax et charbon
Arrese, J. E.; Pierard-Franchimont, Claudine ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2001), 56(10), 685-8

Anthrax is a name given in French language to two distinct infectious diseases. One corresponds to carbuncle which is a collection of boils. The other one corresponds to the English term anthrax. This ... [more ▼]

Anthrax is a name given in French language to two distinct infectious diseases. One corresponds to carbuncle which is a collection of boils. The other one corresponds to the English term anthrax. This condition has a clinical presentation and an outcome that vary according to the inoculation site being cutaneous, pulmonary or digestive, and to the bacterial and toxin spread in the body. [less ▲]

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See detailEtude clinique du mois. Rôle néphroprotecteur des antagonistes du récepteur de l'angiotensine II (ARA) dans le diabète de type 2: résultats des études IDNT et RENAAL
Weekers, Laurent ULiege; Krzesinski, Jean-Marie ULiege

in Revue Médicale de Liège (2001), 56(10), 723-726

Nephropathy associated with type 2 diabetes mellitus is a rising cause of end-stage renal disease and is a major public health problem. If blocking of the renin angiotensin system has a well established ... [more ▼]

Nephropathy associated with type 2 diabetes mellitus is a rising cause of end-stage renal disease and is a major public health problem. If blocking of the renin angiotensin system has a well established nephroprotective effect in type 1 diabetic nephropathy, this remained to be shown for type 2 diabetes. Two large outcome trials using angiotensin II receptor antagonists (ARA's) in proteinuric chronic renal impairment and hypertensive type 2 diabetic patients have now closed this gap: the Irbesartan Diabetic Nephropathy Trial (IDNT) and the Reduction of Endpoints in NIDDM with Angiotensin II Antagonist Losartan (RENAAL) trial. Both trials showed a significant reduction in the primary pre-specified end-point of death, or worsening of renal function (doubling of serum creatinine) or the development of end-stage renal disease. This effect goes beyond the reduction in blood pressure and makes of ARA's one of the important tools in the treatment of type 2 diabetic nephropathy. [less ▲]

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See detailLa bronchopneumopathie chronique obstructive (BPCO): concepts actuels
Louis, Renaud ULiege

in Revue Médicale de Liège (2001), 56(10), 689-95

COPD is a widespread disease in western countries affecting 10% of adults and linked to tobacco consumption in 90% of cases. This disorder is characterized by a reduced maximal expiratory flow which is ... [more ▼]

COPD is a widespread disease in western countries affecting 10% of adults and linked to tobacco consumption in 90% of cases. This disorder is characterized by a reduced maximal expiratory flow which is irreversible and slowly progressive over the years. In those who are genetically prone to develop a COPD, chronic exposure to toxic fumes or particles generates a bronchiolitis and an emphysema which cause disturbances in ventilation mechanics and alveolar gaz exchange. This leads to symptoms of breathlessness, hypoxemia, pulmonary hypertension and, in end stage disease, cor pulmonale. The smoking cessation is the only way to prevent the occurrence of COPD. [less ▲]

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See detailLe sens de la coherence et l'engagement dans un programme de revalidation cardiaque suite a un infarctus du myocarde: resultats preliminaires
Breuer, Bénédicte; Etienne, Anne-Marie ULiege

in Revue Médicale de Liège (2001), 56(10), 703-708

This study investigate the impact of the sense of coherence or SOC (1) on the commitment to health behaviors, as the participation in a revalidation program (physical training) after a first myocardial ... [more ▼]

This study investigate the impact of the sense of coherence or SOC (1) on the commitment to health behaviors, as the participation in a revalidation program (physical training) after a first myocardial infarction. Fifteen subjects have been assessed three times after their myocardial infarction. The data indicate a possible effect of the sense of coherence which is higher among participants in comparison with subjects who refused to be involved in the program. [less ▲]

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See detailL'image du mois. Tumeurs et ulcerations en rouge et blanc
Goffin, Véronique ULiege; Hermanns-Lê, Trinh ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2001), 56(9), 597-8

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See detailA la recherche de la sagesse entre les defensines et les antiseptiques a la surface de la peau
Goffin, Véronique ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2001), 56(9), 635-8

The density in the natural bacterial flora is quite controlled at the skin surface. The barrier to their penetration inside the body is a major function of the stratum corneum. Its more or less ... [more ▼]

The density in the natural bacterial flora is quite controlled at the skin surface. The barrier to their penetration inside the body is a major function of the stratum corneum. Its more or less anfractuous structure, its hydration and acidic pH are important to maintain the microbiological equilibrium. The non-immune innate or inducible natural defenses rely on the production of epithelial peptide antibiotics (defensins, calprotectin) by keratinocytes. The phagocytic and immune defenses are superimposed to such mechanisms. This whole conundrum may be helped by, but it may also suffer from some skin care products and antiseptics. [less ▲]

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See detailLe cas clinique du mois. Syndrome carcinoïde sur tumeur sécrétante du grêle terminal avec cardiopathie
Compere, C.; Geronooz, Isabelle; Croes, F. et al

in Revue Médicale de Liège (2001), 56(9), 599-606

Uncommon but classically described, intestinal carcinoid tumors represent a variety of neuroendocrine tumors. Able to secrete amines and hormones, they can produce characteristic symptoms called ... [more ▼]

Uncommon but classically described, intestinal carcinoid tumors represent a variety of neuroendocrine tumors. Able to secrete amines and hormones, they can produce characteristic symptoms called "carcinoid syndrome". A cardiopathy is sometimes associated with the disease and carries a high risk of mortality and morbidity. [less ▲]

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See detailLe cas clinique du mois. A propos d'un cas d'hypertension portopulmonaire
Blaise, Pierre ULiege; Louis, Renaud ULiege; Quaden, C. et al

in Revue Médicale de Liège (2001), 56(9), 607-11

A case of portopulmonary hypertension discovered during exploration of an atypical faint is described and the pathophysiology and management are discussed.

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See detailLes toxidermies iatrogenes, une rancon de la quete de la sante
Fumal, I.; Sriha, B.; Paquet, Philippe ULiege et al

in Revue Médicale de Liège (2001), 56(8), 583-91

Muco-cutaneous drug reactions are side effects secondary to the intake of various medications. They are quite frequent and diverse in their clinical presentation, pathogeny, histology and prognosis. It is ... [more ▼]

Muco-cutaneous drug reactions are side effects secondary to the intake of various medications. They are quite frequent and diverse in their clinical presentation, pathogeny, histology and prognosis. It is important to diagnose and adequately monitor the disease in its early evolving phase. [less ▲]

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See detailComment intégrer l'automesure de la pression artérielle dans la mise au point de l'hypertendu
Krzesinski, Jean-Marie ULiege

in Revue Médicale de Liège (2001), 56(8), 552-556

Blood pressure measurement is the cornerstone of the diagnosis and follow up of arterial hypertension. Because of its large variability, the office blood pressure measurement can hardly be trusted. The ... [more ▼]

Blood pressure measurement is the cornerstone of the diagnosis and follow up of arterial hypertension. Because of its large variability, the office blood pressure measurement can hardly be trusted. The blood pressure self measurement allows more precisely to select the hypertensive patients (BP > 135/85 mmHg), to follow with more accuracy patients with important blood pressure variability and to check the efficacy of antihypertensive treatment. The self blood pressure measurement is at the early stage of its scientific period of development but requires the use of strictly validated devices which only measure the blood pressure at the brachial level. [less ▲]

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See detailLe cas clinique du mois. Syndrome dyskinetique majeur induit par la ranitidine
Fouddah, A.; Canivet, Jean-Luc ULiege; Damas, Pierre ULiege

in Revue Médicale de Liège (2001), 56(8), 548-551

We report a case of severe dyskinetic syndrome, consisting of intense myoclonia movements, associated with choreiform activity involving the face and upper extremities. The abnormal movements occurred in ... [more ▼]

We report a case of severe dyskinetic syndrome, consisting of intense myoclonia movements, associated with choreiform activity involving the face and upper extremities. The abnormal movements occurred in a patient with confusion and visual hallucinations. This syndrome had an abrupt onset in a patient recovering from coronary artery bypass surgery complicated by an early post-operative cardiac arrest and acute renal failure. Dyskinesia appeared several days after intravenous administration of ranitidine for stress ulcer prophylaxis. Several etiologies were raised in this case among which were post-anoxic myoclonia and metabolic encephalopathy. Cessation of histamine receptor blocker therapy for 48 hours was associated with return of normal cognitive function and disappearance of abnormal movements. This confirmed the iatrogenic nature of the syndrome related to administration of ranitidine. [less ▲]

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See detailAccidents thrombo-emboliques veineux et arteriels chez un patient porteur d'une mutation du facteur V R506Q Leiden et ayant developpe une reaction immuno-allergique a l'heparine
Letawe-Gilis, L.; Lambermont, Bernard ULiege; David, Jean-Louis ULiege

in Revue Médicale de Liège (2001), 56(7), 493-6

A forty-six-year old in-patient was treated with heparin for massive pulmonary embolism. During the hospitalization, the clinical evolution was unusual and characterised as follows: a) the extent of ... [more ▼]

A forty-six-year old in-patient was treated with heparin for massive pulmonary embolism. During the hospitalization, the clinical evolution was unusual and characterised as follows: a) the extent of pulmonary embolism justified a thrombolysis by streptokinase; b) an acute thrombocytopenia occurred a few days later, preceded by a slower, but significant decrease of platelet count; c) a non-occlusive aortic thrombosis developed, distal to renal arteries, causing distal embolisation, successfully treated by local fibrinolysis. The prompt correction of platelet count after interruption of heparin therapy confirmed the diagnosis, before the detection of antibodies against heparin-PF4 complexes. Heparin was immediately replaced by another direct anticoagulant, recombinant hirudin (lepirudine-Refludan), initially given alone and progressively replaced by an antivitamin K (Sintrom). The occurrence of distal embolism from aortic thrombosis, developed during the critical period, characterizes this syndrome, which appears rare but whose incidence is probably underestimated. A subsequent investigation for risk factors for venous thromboembolism in this patient revealed a heterozygous mutation of the Leiden type factor V in our patient, and also in others family members. [less ▲]

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See detailComment positionner l'acéclofénac au sein de l'arsenal thérapeutique des pathologies ostéo-articulaires chroniques ?
Reginster, Jean-Yves ULiege; Paul, I.; Henrotin, Yves ULiege

in Revue Médicale de Liège (2001), 56(7), 484-8

The aim of this article is to critically review the potential role of aceclofenac in the treatment of inflammatory pain and chronic osteoarticular disorder, based on its activity on the mediators of ... [more ▼]

The aim of this article is to critically review the potential role of aceclofenac in the treatment of inflammatory pain and chronic osteoarticular disorder, based on its activity on the mediators of inflammation, its effect on cartilage remodeling and on the results of clinical studies comparing aceclofenac with other NSAIDs in these disorders. Aceclofenac has an outstanding anti-inflammatory profile, involving besides a classical inhibition of prostaglandins E2, a decrease in the expression of several cytokines including interleukin 1 and tumor necrosis factor alpha. It also inhibits activated oxygen species production and influences cells adhesion. Aceclofenac and its main metabolite, 4-hydroxyaceclofenac, has positive effects on cartilage anabolism combined with modulating effect of matrix catabolism. Clinically, aceclofenac has been consistently shown to have a similar efficacy than that of widely marketed NSAIDs and a tolerance profile at least as good, if not better than the profile observed for other NSAIDs in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. As of today, no head to head comparison between aceclofenac and coxibs have been performed, nor for efficacy neither for tolerance. The specific profile of aceclofenac makes this NSAID an interesting candidate for long-term treatment of chronic rheumatic disorders as well as for treatment of acute inflammatory episodes. [less ▲]

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See detailL'image du mois. Souvenir de voyage en nouvelle pangee
Arrese, J. E.; Chian-Garcia, C.; Pierard, Gérald ULiege

in Revue Médicale de Liège (2001), 56(7), 473

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