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See detailHIV Latency: Should We Shock or Lock?
DARCIS, Gilles ULiege; Van Driessche, B.; Van Lint, C.

in Trends in Immunology (2017), 38(3), 217-228

Combinatory antiretroviral therapy (cART) increases the survival and quality of life of HIV-1-infected patients. However, interruption of therapy almost invariably leads to the re-emergence of detectable ... [more ▼]

Combinatory antiretroviral therapy (cART) increases the survival and quality of life of HIV-1-infected patients. However, interruption of therapy almost invariably leads to the re-emergence of detectable viral replication because HIV-1 persists in viral latent reservoirs. Improved understanding of the molecular mechanisms involved in HIV-1 latency has paved the way for innovative strategies that attempt to purge latent virus. In this article we discuss the results of the broadly explored ‘shock and kill’ strategy, and also highlight the major hurdles facing this approach. Finally, we present recent innovative works suggesting that locking out latent proviruses could be a potential alternative therapeutic strategy. © 2016 Elsevier Ltd [less ▲]

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See detailNew models for analyzing mast cell functions in vivo.
Marichal, Thomas ULiege; Reber, Laurent L; Galli, Stephen J.

in Trends in Immunology (2012), 33(12), 613-25

In addition to their well-accepted role as critical effector cells in anaphylaxis and other acute IgE-mediated allergic reactions, mast cells (MCs) have been implicated in a wide variety of processes that ... [more ▼]

In addition to their well-accepted role as critical effector cells in anaphylaxis and other acute IgE-mediated allergic reactions, mast cells (MCs) have been implicated in a wide variety of processes that contribute to disease or help to maintain health. Although some of these roles were first suggested by analyses of MC products or functions in vitro, it is critical to determine whether, and under which circumstances, such potential roles actually can be performed by MCs in vivo. This review discusses recent advances in the development and analysis of mouse models to investigate the roles of MCs and MC-associated products during biological responses in vivo, and comments on some of the similarities and differences in the results obtained with these newer versus older models of MC deficiency. [less ▲]

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See detailEpithelial metaplasia: an inadequate environment for antitumour immunity?
Delvenne, Philippe ULiege; Hubert, Pascale ULiege; Jacobs, Nathalie ULiege

in Trends in Immunology (2004), 25(4), 169-73

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See detailLymphocyte Kinetics: The Interpretation Of Labelling Data
Asquith, B.; Debacq, C.; Macallan, Dc. et al

in Trends In Immunology (2002), 23(12),

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