References of "2014"
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See detailQuantitative rates of brain glucose metabolism distinguish minimally conscious from vegetative state patients
Stender, Johan; Kupers, Ron; Rodell, Anders et al

in Journal of Cerebral Blood Flow and Metabolism (2014)

The differentiation of the vegetative or unresponsive wakefulness syndrome (VS/UWS) from the minimally conscious state (MCS) is an important clinical issue. The cerebral metabolic rate of glucose (CMRglc ... [more ▼]

The differentiation of the vegetative or unresponsive wakefulness syndrome (VS/UWS) from the minimally conscious state (MCS) is an important clinical issue. The cerebral metabolic rate of glucose (CMRglc) declines when consciousness is lost, and may reveal the residual cognitive function of these patients. However, no quantitative comparisons of cerebral glucose metabolism in VS/UWS and MCS have yet been reported. We calculated the regional and whole-brain CMRglc of 41 patients in the states of VS/UWS (n = 14), MCS (n = 21) or emergence from MCS (EMCS, n = 6), and healthy volunteers (n = 29). Global cortical CMRglc in VS/UWS and MCS averaged 42% and 55% of normal, respectively. Differences between VS/UWS and MCS were most pronounced in the frontoparietal cortex, at 42% and 60% of normal. In brainstem and thalamus, metabolism declined equally in the two conditions. In EMCS, metabolic rates were indistinguishable from those of MCS. Ordinal logistic regression predicted that patients are likely to emerge into MCS at CMRglc above 45% of normal. Receiver-operating characteristics showed that patients in MCS and VS/UWS can be differentiated with 82% accuracy, based on cortical metabolism. Together these results reveal a significant correlation between whole-brain energy metabolism and level of consciousness, suggesting that quantitative values of CMRglc reveal consciousness in severely brain-injured patients. [less ▲]

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See detailRecent Developments in State Aid Law
Derenne, Jacques ULiege; Citron, Peter; Domecq, Mateo et al

in Journal of European Competition Law and Practice (2014), 5(1), 53-61

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See detailLa vaisselle domestique et funéraire dans la vallée de la Meuse moyenne
Van Wersch, Line ULiege

in Bulletin de liaison de l’AFAM (2014)

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See detailExertional hypoxemia in stable COPD is common and predicted by circulating proadrenomedullin.
Stolz, Daiana; Boersma, Wim; Blasi, Francesco et al

in CHEST (2014)

BACKGROUND: The prevalence of exertional hypoxemia in unselected COPD patients is unknown. Intermittent hypoxia leads to adrenomedullin (ADM) up regulation through the HIF-1 pathway. We aimed to assess ... [more ▼]

BACKGROUND: The prevalence of exertional hypoxemia in unselected COPD patients is unknown. Intermittent hypoxia leads to adrenomedullin (ADM) up regulation through the HIF-1 pathway. We aimed to assess the prevalence and the annual probability to develop exertional hypoxemia in stable COPD. We also hypothesized that increased ADM might be associated with exertional hypoxemia and envisioned that adding ADM to clinical variables might improve its prediction in COPD. METHODS: 1233 6-minute walking tests and circulating proadrenomedullin levels from 574 patients with clinically stable, moderate to very severe COPD enrolled in a multinational cohort study and followed-up for 2 years were concomitantly analyzed. RESULTS: The prevalence of exertional hypoxemia was 29.1%. In a matrix derived from a fitted-multi-state model, the annual probability to develop exertional hypoxemia was 21.6%. Exertional hypoxemia was associated with greater deterioration of specific domains of health-related QoL, higher severe exacerbation and death annual rates. In the logistic linear and conditional Cox-regression multivariable analyses, both FEV1% predicted and proADM proved independent predictors of exertional hypoxemia (p<0.001 for both). Adjustment for comorbidities, including cardiovascular disorders, and exacerbation-rate did not influence results. Relative to using FEV1% pred alone, adding proADM resulted in a significant improvement of the predictive properties (p=0.018). Based on the suggested non-linear nomogram, patients with moderate COPD (FEV1 predicted=50%) but high proADM levels (>2nmol/l) presented increased risk (>30%) for exertional desaturation. CONCLUSIONS: Exertional desaturation is common and associated with poorer clinical outcomes in COPD. Adrenomedullin improves prediction of exertional desaturation as compared to the use of FEV1%pred alone. [less ▲]

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See detailAntitrust damages in EU law and policy: Introduction. Series n° 5
Derenne, Jacques ULiege; Morgan de Rivery, Eric; Petit, Nicolas ULiege

in Derenne, Jacques; Morgan de Rivery, Eric; Petit, Nicolas (Eds.) Antitrust damages in EU law and policy, GCLC, College of Europe - Annual Conference Series n° 5 (2014)

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See detailOptimization of organic and conventional olive agricultural practices from a Life Cycle Assessment and Life Cycle Costing perspectives
Mohamad, R. S.; Verrastro, V.; Cardone, G. et al

in Journal of Cleaner Production (2014), 70

Olive growing is an important cultural and traditional system in the Mediterranean region that has considerable environmental impacts. Italy is ranked second in the world in terms of olive production and ... [more ▼]

Olive growing is an important cultural and traditional system in the Mediterranean region that has considerable environmental impacts. Italy is ranked second in the world in terms of olive production and olive-cultivated area. Apulia is Italy's largest olive growing region and accounts for 33% of the total Italian surface area planted to olive trees. Organic farming is assumed to have beneficial effects by reducing the environmental impacts of agricultural practices. However, literature shows that this system is not always less harmful to the environment than the conventional one. This study investigates this hypothesis through the comparison of environmental impacts and economic performances between organic and conventional olive systems in Apulia region. It also provides options to optimize the agricultural practices that could contribute to the reduction of the environmental impacts. Life Cycle Assessment (LCA) was applied to evaluate the environmental impacts, and Life Cycle Costing (LCC) was utilized to assess the economic performance of the studied systems referring to one hectare as functional unit and to a system boundary limited to olive production (cradle-to-farm gate). Results showed a lower environmental impact of agricultural practices in the organic system, mainly due to the higher efficiency in reducing the impact on fossil fuel depletion. Moreover, the organic system resulted to have higher Net Present Value and Internal Rate of Return values that indicate its higher profitability as compared to the conventional system. Optimization of fertilization is the first priority to optimize olive growing, particularly in the organic system, since manure fertilization results in higher costs and higher environmental impact on almost all impact categories compared to synthetic foliar fertilization. Good agricultural practices with electrically-driven irrigation system, mechanical weeding and biological pest control, no-tillage or reduced tillage can be considered as further optimization options to mitigate environmental burdens and reduce their costs. © 2014 Elsevier Ltd. All rights reserved. [less ▲]

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See detailEconomic and environmental sustainability of forestry measures in Apulia Region Rural Development Plan: An application of life cycle approach
Moretti, Michele ULiege; De Boni, A.; Roma, R.

in Land Use Policy (2014), 41

This article investigates the applicability of combined Life Cycle Assessment and market analysis, to support efficiency evaluation of rural development strategies developed by the Apulian Rural ... [more ▼]

This article investigates the applicability of combined Life Cycle Assessment and market analysis, to support efficiency evaluation of rural development strategies developed by the Apulian Rural Development Plan 2007-2013 (BURP n 93 26/05/2010). Measure 122 "Improving the economic value of forest" had the aim to improve of forestry farms technological resources addressing them toward the biomass production. As an example pellet production from sawmill residues (PSR) and firewood productions have been compared both under environmental and economic performances. The functional unit (FU) is 1kWh of residential thermal energy. Environmental impacts of both fuels have been evaluated through the Life Cycle Assessment methodology, considering the most relevant impact categories: the damages on human health, the ecosystems qualities, the kg of CO2eq. produced (GWP100) and the balance between energy requests and consumed (Cumulative Energy Demand - CED). About the economic analysis, data on pellet and firewood local market prices have been collected and consumer's expenditure for FU calculated. Results supplied relevant suggestions to improve efficiency and farmer's subscription to Apulia Regional Development Plan forestry measures. © 2014 Elsevier Ltd. [less ▲]

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See detailEuropean Competition Law. A Case Commentary: State Aid
Derenne, Jacques ULiege

in Verloren van Themaat, Weijer; Reuder, Berend (Eds.) European Competition Law: A Case Commentary (2014)

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See detailMultifactorial Relationship Between 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography Signaling and Biomechanical Properties in Unruptured Aortic Aneurysms
NCHIMI LONGANG, Alain ULiege; CHERAMY-BIEN, Jean-Paul ULiege; Gasser, T. Christian et al

in Circulation: Cardiovascular Imaging (2014), 7

BACKGROUND: -The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations (FES) and 18F-fluoro-deoxyglucose (18F-FDG ... [more ▼]

BACKGROUND: -The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations (FES) and 18F-fluoro-deoxyglucose (18F-FDG) positron emission tomography (PET). METHODS AND RESULTS: -The study included 53 patients (45 males) with aortic aneurysms, 47 infrarenal (AAA) and 6 thoracic (TAA), who had at least one 18F-FDG PET/computed tomography. Over a 30-month period, more clinical events occurred in patients with increased 18F-FDG uptake on their last examination than in those without (5/18 (28%) vs. 2/35 (6%); P=0.03). Wall stress and stress/strength index computed by FES and 18F-FDG uptake were evaluating a total of 68 examinations. 25 (38%) examinations demonstrated at least one aneurysm wall area of increased 18F-FDG uptake. The mean number of these areas per examination was 1.6 (18/11) in TAAs vs. 0.25 (14/57) in AAAs, while the mean number of increased uptake areas co-localizing with highest wall stress and stress/strength index areas was 0.55 (6/11) and 0.02 (1/57), respectively. Quantitatively, 18F-FDG PET uptake correlated positively with both wall stress and stress/strength index (P<0.05). 18F-FDG uptake was particularly high in subjects with personal history of angina pectoris and familial aneurysm. CONCLUSIONS: -Increased 18F-FDG PET uptake in aortic aneurysms is strongly related to aneurysm location, wall stress as derived by FES and patient's risk factors such as acquired and inherited susceptibilities. [less ▲]

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See detailAbbey van Stavelot. Archeologisch vensterglas – recent onderzoek
Fontaine, Chantal; Neuray, Brigitte; Van Wersch, Line ULiege

in Novi Monasterii, Lost Luster. Innovative Interdisciplinary research on archaeological window glass in North Western Europe (2014)

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See detailHow Does Pollen Chemistry Impact Development and Feeding Behaviour of Polylectic Bees?
Vanderplanck, Maryse ULiege; Moerman, Romain; Rasmont, Pierre et al

in PLoS ONE (2014), 9(1), 9

Larvae and imagos of bees rely exclusively on floral rewards as a food source but host-plant range can vary greatly among bee species. While oligolectic species forage on pollen from a single family of ... [more ▼]

Larvae and imagos of bees rely exclusively on floral rewards as a food source but host-plant range can vary greatly among bee species. While oligolectic species forage on pollen from a single family of host plants, polylectic bees, such as bumblebees, collect pollen from many families of plants. These polylectic species contend with interspecific variability in essential nutrients of their host-plants but we have only a limited understanding of the way in which chemicals and chemical combinations influence bee development and feeding behaviour. In this paper, we investigated five different pollen diets (Calluna vulgaris, Cistus sp., Cytisus scoparius, Salix caprea and Sorbus aucuparia) to determine how their chemical content affected bumblebee colony development and pollen/syrup collection. Three compounds were used to characterise pollen content: polypeptides, amino acids and sterols. Several parameters were used to determine the impact of diet on micro-colonies: (i) Number and weight of larvae (total and mean weight of larvae), (ii) weight of pollen collected, (iii) pollen efficacy (total weight of larvae divided by weight of the pollen collected) and (iv) syrup collection. Our results show that pollen collection is similar regardless of chemical variation in pollen diet while syrup collection is variable. Micro-colonies fed on S. aucuparia and C. scoparius pollen produced larger larvae (i.e. better mates and winter survivors) and fed less on nectar compared to the other diets. Pollen from both of these species contains 24-methylenecholesterol and high concentrations of polypeptides/total amino acids. This pollen nutritional “theme” seems therefore to promote worker reproduction in B. terrestris micro-colonies and could be linked to high fitness for queenright colonies. As workers are able to selectively forage on pollen of high chemical quality, plants may be evolutionarily selected for their pollen content, which might attract and increase the degree of fidelity of generalist pollinators, such as bumblebees. [less ▲]

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See detailCx30 (GJB6) inhibits cell growth in human malignant gliomas but mediates radiation resistance
Artesi, Maria ULiege; Kroonen, Jerome; Poulet, Christophe ULiege et al

in Neuro-Oncology (2014)

Connexins (Cxs) are potentially key players in the control of tumor cell proliferation. Normal astrocytes express large amounts of connexin30 and we have previously demonstrated its underexpression in rat ... [more ▼]

Connexins (Cxs) are potentially key players in the control of tumor cell proliferation. Normal astrocytes express large amounts of connexin30 and we have previously demonstrated its underexpression in rat glioma cells. Here we report that a Cx30 gene deletion occurs in approximately 30% of human glioblastomas (GBMs). Cx30 mRNA levels are decreased in these tumors compared to glial tumors of lower grade and to non tumoral tissues. At the protein level, Cx30 is lost in approximately one third of the tumors in our cohort of 230 glioblastoma biopsies. Restoration of Cx30 in U87 glioma cell lines and in glioma primary cultures (GM1), effectively retards cell proliferation in vitro and inhibits tumor growth in vivo. This correlates with a decrease in TCF, CK2 and NFkappaB activity and with altered expression levels of cell cycle control proteins such as cyclin D1, P27, P21 and c-myc. In patient biopsies, Cx30 expression was found in tumor regions displaying a lower Ki-67 proliferative index. Interestingly, in our cohort of malignant glioma patients, Cx30 expression proved to be an adverse prognostic factor. Here, we demonstrate its role in mediating cell survival and a hypermetabolic state after radiation treatment in human glioma cells. Mechanistically, we propose that a HSP90- mediated Cx30 translocation into mitochondria occurs after radiation treatment. The inhibition of the HSP90 molecular chaperone with geldamycin inhibits the radiation- induced translocation of Cx30 into mitochondria, decreasing the hypermetabolic state and restoring radiation sensitivity in those cells. These results demonstrate the central regulatory role of connexin30 in the biology of human gliomas. [less ▲]

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See detailAnatomical changes at the level of the primary synapse in chronic pain
Wilcox, Sophie ULiege

Doctoral thesis (2014)

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See detailRF modulator design for a low level pilot sub-system
Eslampanah, R.; Pourakbar, M.; Ahmed, S. et al

in Australian Microwave Symposium, Conference Proceedings (2014)

This paper presents an adaptive duplexer using cancelling instead of filtering to obtain sufficient transmitter (Tx) leakage and noise isolation in the receiver. A low level pseudo-noise (PN) pilot signal ... [more ▼]

This paper presents an adaptive duplexer using cancelling instead of filtering to obtain sufficient transmitter (Tx) leakage and noise isolation in the receiver. A low level pseudo-noise (PN) pilot signal is introduced in order to adjust the cancelling coefficients. To modulate the pilot signal to radio frequencies a straightforward direct up-conversion mixer with low carrier feedthrough has been designed. This structure has been implemented in the silicon-on-sapphire (SOS) 250 nm GC process. © 2014 IEEE. [less ▲]

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See detailLe bol en verre à décor réticulé
Van Wersch, Line ULiege; Mathis, François

Conference (2014)

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See detailRpb4/7 facilitates RNA polymerase II CTD dephosphorylation
Allepuz Fuster, Paula ULiege; Martínez-Fernández, Veronica; Garrido-Godino, Ana Isabel et al

in Nucleic Acids Research (2014)

Detailed reference viewed: 10 (1 ULiège)