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See detailCdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system.
Caillava, Céline; Vandenbosch, Renaud ULiege; Jablonska, Beata et al

in Journal of Cell Biology (2011), 193(2), 397-407

The specific functions of intrinsic regulators of oligodendrocyte progenitor cell (OPC) division are poorly understood. Type 2 cyclin-dependent kinase (Cdk2) controls cell cycle progression of OPCs, but ... [more ▼]

The specific functions of intrinsic regulators of oligodendrocyte progenitor cell (OPC) division are poorly understood. Type 2 cyclin-dependent kinase (Cdk2) controls cell cycle progression of OPCs, but whether it acts during myelination and repair of demyelinating lesions remains unexplored. Here, we took advantage of a viable Cdk2(-/-) mutant mouse to investigate the function of this cell cycle regulator in OPC proliferation and differentiation in normal and pathological conditions. During central nervous system (CNS) development, Cdk2 loss does not affect OPC cell cycle, oligodendrocyte cell numbers, or myelination. However, in response to CNS demyelination, it clearly alters adult OPC renewal, cell cycle exit, and differentiation. Importantly, Cdk2 loss accelerates CNS remyelination of demyelinated axons. Thus, Cdk2 is dispensable for myelination but is important for adult OPC renewal, and could be one of the underlying mechanisms that drive adult progenitors to differentiate and thus regenerate myelin. [less ▲]

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See detailMedieval Genders and Sexualities in Europe: Construction, Transformation, and Subversion, 600–1530
L'Estrange, Elizabeth ULiege; More, Alison

Book published by Ashgate (2011)

With a specific focus on the themes of construction, subversion and transformation, this collection of essays makes an innovative contribution to the study of genders and sexual identity in the Middle ... [more ▼]

With a specific focus on the themes of construction, subversion and transformation, this collection of essays makes an innovative contribution to the study of genders and sexual identity in the Middle Ages. Scholars from a variety of disciplinary backgrounds deal with the presentation or transformation of gender, third-gender, and the relationship between gender and sexual identity in fields such as literature, hagiography, and art history, from the Anglo-Saxon period to the early sixteenth century. The contributors offer in-depth analyses on specific subjects—including French romance literature, saints’ vitae, Italian visual cultures, and manuscript studies—as well as providing food for thought for scholars outside medieval studies who are interested in the themes of gender transformation and presentation. Engaging with current academic debates over the complexities and pluralities of gender identity in the Middle Ages, this volume is one of the first collections to show how the themes of gender construction and transformation can be applied over a wide range of fields. [less ▲]

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See detailStructure and development of cochlear afferent innervation in mammals.
Defourny, Jean ULiege; Lallemend, Francois; Malgrange, Brigitte ULiege

in American Journal of Physiology - Cell Physiology (2011), 301(4), 750-61

In mammals, sensorineural deafness results from damage to the auditory receptors of the inner ear, the nerve pathways to the brain or the cortical area that receives sound information. In this review, we ... [more ▼]

In mammals, sensorineural deafness results from damage to the auditory receptors of the inner ear, the nerve pathways to the brain or the cortical area that receives sound information. In this review, we first focused on the cellular and molecular events taking part to spiral ganglion axon growth, extension to the organ of Corti, and refinement. In the second half, we considered the functional maturation of synaptic contacts between sensory hair cells and their afferent projections. A better understanding of all these processes could open insights into novel therapeutic strategies aimed to re-establish primary connections from sound transducers to the ascending auditory nerve pathways. [less ▲]

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See detailThe reduction of the stress response by jasmonic acid and putrescine has a beneficial effect on in vitro tuber formation and development of yam
Kevers, Claire ULiege

in Plant Abiotic Stress: From Systems Biology to Sustainable Agriculture 4th International Workshop - Cost Action FA0605 17-17 November 2011 (2011)

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See detailNeuroendocrine disruption: the emerging concept.
Trudeau, Vance L; Kah, Olivier; Bourguignon, Jean-Pierre ULiege

in Journal of Toxicology and Environmental Health. Part B, Critical Reviews (2011), 14(5-7), 267-9

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See detailBacteria and nanoscale biophysics
Silhanek, Alejandro ULiege; Vanderleyden, Jozef

in Microbial Biotechnology (2011), 4(2), 129-130

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See detailLa répression du négationnisme en Belgique : de la réussite législative au blocage politique
Grandjean, Geoffrey ULiege

in Droit et Société (2011), 1(77), 137-160

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See detailSafety observations from denosumab long-term extension and cross-over studies in postmenopausal women with osteoporosis
Bone, H. G.; Chapurlat, R.; Libanati, C. et al

in Journal of Bone and Mineral Research (2011), 26(S1), 22-23

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See detailLoi du 2 juin 2010 et les qualités de l’association des copropriétaires : délicates nuances entre procédure et fond
Lecocq, Pascale ULiege; Salvé, Arianne ULiege

in Revue de la Faculté de Droit de l'Université de Liège (2011), (3-4), 555-568

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See detailLocal and systemic cellular inflammation and cytokine release in chronic obstructive pulmonary disease.
Moermans, Catherine ULiege; HEINEN, Vincent ULiege; NGUYEN DANG, Delphine ULiege et al

in Cytokine (2011), 56(2), 298-304

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease caused by repeated exposure to noxious gases or particles. It is now recognized that the disease also ... [more ▼]

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease caused by repeated exposure to noxious gases or particles. It is now recognized that the disease also features systemic inflammation. The purpose of our study was to compare airway and systemic inflammation in COPD to that seen in healthy subjects and to relate the inflammation with the disease severity. METHODS: Ninety-five COPD patients, encompassing the whole severity spectrum of the disease, were recruited from our outpatient clinic and rehabilitation center and compared to 33 healthy subjects. Induced sputum and blood samples were obtained for measurement of inflammatory cell count. Interleukin (IL)-4, IL-6, IL-10, TNF-alpha and IFN-gamma produced by 24h sputum and blood cell cultures were measured. RESULTS: Compared to healthy subjects, COPD exhibited a prominent airway neutrophilic inflammation associated with a marked IL-10, IL-6 and TNF-alpha release deficiency that contrasted with a raised IFN-gamma production. Neutrophilic inflammation was also prominent at blood level together with raised production of IFN-gamma, IL-10 and TNF-alpha. Furthermore, sputum neutrophilia correlated with disease severity assessed by GOLD stages. Likewise the extent of TNF-alpha release from blood cells also positively correlated with the disease severity but negatively with that of sputum cell culture. Blood release of TNF-alpha and IL-6 negatively correlated with body mass index. Altogether, our results showed a significant relationship between cellular marker in blood and sputum but poor relationship between local and systemic release of cytokines. CONCLUSIONS: COPD is characterized by prominent neutrophilic inflammation and raised IFN-gamma production at both bronchial and systemic level. Overproduction of TNF-alpha at systemic level correlates with disease severity and inversely with body mass index. [less ▲]

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See detailL'image du mois : occlusion grêle sur hernie abdominale interne au travers de l'hiatus de Winslow
LEJEUNE, Jean-Luc ULiege; BRASSEUR, Edmond ULiege; lewin, M. et al

in Revue Médicale de Liège (2011), 66(9), 464-65

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See detailPauvreté et mortalité différentielle chez les personnes âgées
Lefebvre, Mathieu ULiege; Pestieau, Pierre ULiege; Ponthiere, Grégory ULiege

in Reflets et Perspectives de la Vie Economique (2011), L(4), 45-54

Cette note a pour objectif d’illustrer, dans le cas de la Belgique et de ses régions, un problème particulier posé par la mesure de la pauvreté. Etant donné que la mortalité varie selon le niveau de ... [more ▼]

Cette note a pour objectif d’illustrer, dans le cas de la Belgique et de ses régions, un problème particulier posé par la mesure de la pauvreté. Etant donné que la mortalité varie selon le niveau de revenu – les personnes aux revenus plus élevés vivant plus longtemps, en moyenne, que les personnes aux revenus plus faibles – les taux de pauvreté calculés pour les classes âgées dépendent non seulement de ce que l’on pourrait appeler la vraie pauvreté, mais aussi de la sélection induite par la mortalité différentielle selon le revenu. En calculant les taux de pauvreté que l’on observerait si des personnes avec différents niveaux de revenus avaient toutes la même espérance de vie, on peut ainsi estimer la vraie pauvreté, en neutralisant les interférences dues à la mortalité différentielle. Cet ajustement des mesures de pauvreté est particulièrement intéressant pour la Belgique, où les écarts de longévité entre Flamands et Francophones et entre riches et moins riches sont importants. [less ▲]

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See detailThe Pbx Interaction Motif of Hoxa1 Is Essential for Its Oncogenic Activity
Delval, Stéphanie; Taminiau, Arnaud; Lamy, Juliette et al

in PLoS ONE (2011), 6(9), 2547

Hoxa1 belongs to the Hox family of homeodomain transcription factors involved in patterning embryonic territories and governing organogenetic processes. In addition to its developmental functions, Hoxa1 ... [more ▼]

Hoxa1 belongs to the Hox family of homeodomain transcription factors involved in patterning embryonic territories and governing organogenetic processes. In addition to its developmental functions, Hoxa1 has been shown to be an oncogene and to be overexpressed in the mammary gland in response to a deregulation of the autocrine growth hormone. It has therefore been suggested that Hoxa1 plays a pivotal role in the process linking autocrine growth hormone misregulation and mammary carcinogenesis. Like most Hox proteins, Hoxa1 can interact with Pbx proteins. This interaction relies on a Hox hexapeptidic sequence centred on conserved Tryptophan and Methionine residues. To address the importance of the Hox-Pbx interaction for the oncogenic activity of Hoxa1, we characterized here the properties of a Hoxa1 variant with substituted residues in the hexapeptide and demonstrate that the Hoxa1 mutant lost its ability to stimulate cell proliferation, anchorage-independent cell growth, and loss of contact inhibition. Therefore, the hexapeptide motif of Hoxa1 is required to confer its oncogenic activity, supporting the view that this activity relies on the ability of Hoxa1 to interact with Pbx. [less ▲]

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See detailTrou du Renard and ongoing work on the Aurignacian of the far North
Dinnis, Rob; Flas, Damien ULiege

Conference (2011)

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See detailAging is associated with more intrusions errors but not more plagiarism errors
Perfect, Timothy James; Defeldre, Anne-Catherine; Elliman, Rachel et al

Conference (2011)

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See detailAutism associated with low 5-hydroxyindolacetic acid in CSF and the heterozygous SLC6A4 gene Gly56Ala plus 5-HTTLPR L/L promoter variants.
Adamsen, Dea; Meili, David; Blau, Nenad et al

in Molecular Genetics & Metabolism (2011), 102(3), 368-73

The known Gly56Ala mutation in the serotonin transporter SERT (or 5-HTT), encoded by the SLC6A4 gene, causes increased serotonin reuptake and has been associated with autism and rigid-compulsive behavior ... [more ▼]

The known Gly56Ala mutation in the serotonin transporter SERT (or 5-HTT), encoded by the SLC6A4 gene, causes increased serotonin reuptake and has been associated with autism and rigid-compulsive behavior. We report a patient with macrocephaly from birth, followed by hypotonia, developmental delay, ataxia and a diagnosis of atypical autism (PDD-NOS) in retrospect at the age of 4(1/2)years. Low levels of the serotonin end-metabolite 5-hydroxyindolacetic acid (5HIAA) in CSF were detected, and SLC6A4 gene analysis revealed the heterozygous Gly56Ala alteration and the homozygous 5-HTTLPR L/L promoter variant. These changes are reported to be responsible for elevated SERT activity and expression, suggesting that these alterations were responsible in our patient for low serotonin turnover in the central nervous system (CNS). Daily treatment with 5-hydroxytryptophan (and carbidopa) led to clinical improvement and normalization of 5HIAA, implying that brain serotonin turnover normalized. We speculate that the mutated 56Ala SERT transporter with elevated expression and basal activity for serotonin re-uptake is accompanied with serotonin accumulation within pre-synaptic axons and their vesicles in the CNS, resulting in a steady-state of lowered serotonin turnover and degradation by monoamine-oxidase (MAO) enzymes in pre-synaptic or neighboring cells. [less ▲]

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See detailOperational Entanglement classification of symmetric N-qubit states
Bastin, Thierry ULiege

Conference (2011)

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