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See detail2D XFEM-based modeling of retraction and successive resections for preoperative image update.
Vigneron, Lara M.; Duflot, Marc P.; Robe, Pierre ULiege et al

in Computer aided surgery : official journal of the International Society for Computer Aided Surgery (2009), 14(1-3), 1-20

This paper considers an approach to improving outcomes for neurosurgery patients by enhancing intraoperative navigation and guidance. Currently, intraoperative navigation systems do not accurately account ... [more ▼]

This paper considers an approach to improving outcomes for neurosurgery patients by enhancing intraoperative navigation and guidance. Currently, intraoperative navigation systems do not accurately account for brain shift or tissue resection. We describe how preoperative images can be incrementally updated to take into account any type of brain tissue deformation that may occur during surgery, and thus to improve the accuracy of image-guided navigation systems. For this purpose, we have developed a non-rigid image registration technique using a biomechanical model, which deforms based on the Finite Element Method (FEM). While the FEM has been used successfully for dealing with deformations such as brain shift, it has difficulty with tissue discontinuities. Here, we describe a novel application of the eXtended Finite Element Method (XFEM) in the field of image-guided surgery in order to model brain deformations that imply tissue discontinuities. In particular, this paper presents a detailed account of the use of XFEM for dealing with retraction and successive resections, and demonstrates the feasibility of the approach by considering 2D examples based on intraoperative MR images. To evaluate our results, we compute the modified Hausdorff distance between Canny edges extracted from images before and after registration. We show that this distance decreases after registration, and thus demonstrate that our approach improves alignment of intraoperative images. [less ▲]

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See detailMonosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas.
Yadav, Ajay K; Renfrow, Jaclyn J; Scholtens, Denise M et al

in JAMA : Journal of the American Medical Association (2009), 302(3), 276-89

CONTEXT: Glioblastomas--uniformly fatal brain tumors--often have both monosomy of chromosome 10 and gains of the epidermal growth factor receptor (EGFR) gene locus on chromosome 7, an association for ... [more ▼]

CONTEXT: Glioblastomas--uniformly fatal brain tumors--often have both monosomy of chromosome 10 and gains of the epidermal growth factor receptor (EGFR) gene locus on chromosome 7, an association for which the mechanism is poorly understood. OBJECTIVES: To assess whether coselection of EGFR gains on 7p12 and monosomy 10 in glioblastomas promotes tumorigenic epidermal growth factor (EGF) signaling through loss of the annexin A7 (ANXA7) gene on 10q21.1-q21.2 and whether ANXA7 acts as a tumor suppressor gene by regulating EGFR in glioblastomas. DESIGN, SETTING, AND PATIENTS: Multidimensional analysis of gene, coding sequence, promoter methylation, messenger RNA (mRNA) transcript, protein data for ANXA7 (and EGFR), and clinical patient data profiles of 543 high-grade gliomas from US medical centers and The Cancer Genome Atlas pilot project (made public 2006-2008; and unpublished, tumors collected 2001-2008). Functional analyses using LN229 and U87 glioblastoma cells. MAIN OUTCOME MEASURES: Associations among ANXA7 gene dosage, coding sequence, promoter methylation, mRNA transcript, and protein expression. Effect of ANXA7 haploinsufficiency on EGFR signaling and patient survival. Joint effects of loss of ANXA7 and gain of EGFR expression on tumorigenesis. RESULTS: Heterozygous ANXA7 gene deletion is associated with significant loss of ANXA7 mRNA transcript expression (P = 1 x 10(-15); linear regression) and a reduction (mean [SEM]) of 91.5% (2.3%) of ANXA7 protein expression compared with ANXA7 wild-type glioblastomas (P = .004; unpaired t test). ANXA7 loss of function stabilizes the EGFR protein (72%-744% increase in EGFR protein abundance) and augments EGFR transforming signaling in glioblastoma cells. ANXA7 haploinsufficiency doubles tumorigenic potential of glioblastoma cells, and combined ANXA7 knockdown and EGFR overexpression promotes tumorigenicity synergistically. The heterozygous loss of ANXA7 in approximately 75% of glioblastomas in the The Cancer Genome Atlas plus infrequency of ANXA7 mutation (approximately 6% of tumors) indicates its role as a haploinsufficiency gene. ANXA7 mRNA transcript expression, dichotomized at the median, associates with patient survival in 191 glioblastomas (log-rank P = .008; hazard ratio [HR], 0.667; 95% confidence interval [CI], 0.493-0.902; 46.9 vs 74.8 deaths/100 person-years for high vs low ANXA7 mRNA expression) and with a separate group of 180 high-grade gliomas (log-rank P = .00003; HR, 0.476; 95% CI, 0.333-0.680; 21.8 vs 50.0 deaths/100 person-years for high vs low ANXA7 mRNA expression). Deletion of the ANXA7 gene associates with poor patient survival in 189 glioblastomas (log-rank P = .042; HR, 0.686; 95% CI, 0.476-0.989; 54.0 vs 80.1 deaths/100 person-years for wild-type ANXA7 vs ANXA7 deletion). CONCLUSION: Haploinsufficiency of the tumor suppressor ANXA7 due to monosomy of chromosome 10 provides a clinically relevant mechanism to augment EGFR signaling in glioblastomas beyond that resulting from amplification of the EGFR gene. [less ▲]

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See detailBehaviour of an engineered clay barrier for A nuclear waste isolation system
François, Bertrand ULiege; Laloui, Lyesse

in Computational Methods for Coupled Problems in Science and Engineering, Coupled Problems’09 (2009)

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See detailCoupled hydro-thermo-mechanical analysis of a deep radioactive waste disposal based on porous media mechanics
Passarotto, Mareva; Luison, Loris; Sanavia, Lorenzo et al

Poster (2009)

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See detailLe Goût et ses Représentations dans le Traité des sens de Claude-Nicolas Le Cat
Von Hoffmann, Viktoria ULiege

in Cahiers de l'Echarp (2009), 2

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See detailEn chemin vers les cancers photo-induits.
Pierard, Gérald ULiege; André, J.; Brochez, L. et al

in Skin (2009), 12

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See detailEffect of different prostaglandin treatment protocols on the time of ovulation and pregnancy rate in dairy cattle
Repasi, A.; Melo de Sousa, Noelita ULiege; Beckers, Jean-François ULiege et al

in Folia Veterinaria (2009), 53(Suppl. 2), 172

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See detailPregnancy-Associated Glycoprotein B-73 kDa [Fragment] from Bubalus bubalis placenta - Access number P86373
Barbato, O.; Melo de Sousa, Noelita ULiege; Barile, V. L. et al

E-print/Working paper (2009)

N-terminal microsequence obtained after purification and characterization of placental proteins in Bubalus bubalis. Proteins were submitted to SwissProt databank.

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See detailPregnancy-Associated Glycoprotein E-65 kDa [Fragment] from Bubalus bubalis placenta - Access number P86376
Barbato, O.; Melo de Sousa, Noelita ULiege; Barile, V. L. et al

E-print/Working paper (2009)

N-terminal microsequence obtained after purification and characterization of placental proteins in Bubalus bubalis. Proteins were submitted to SwissProt databank.

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See detailThe Dusty View of DI from ESO Chile
Boehnhardt, H.; Ageorges, N.; Bagnulo, S. et al

in Käufk, H. U.; Sterken, C. (Eds.) Deep Impact as a World Observatory Event: Synergies in Space, Time, and Wavelength (2009)

Around the time of the impact of NASA's Deep Impact (DI) mission at comet 9P/Tempel 1, in total 6 telescopes with altogether 7 different instruments, located at the La Silla (LSO) and Paranal (VLT ... [more ▼]

Around the time of the impact of NASA's Deep Impact (DI) mission at comet 9P/Tempel 1, in total 6 telescopes with altogether 7 different instruments, located at the La Silla (LSO) and Paranal (VLT) Observatories of the European Southern Observatory (ESO) in Chile, were used to characterize the dust properties before and after the event. The ejecta cloud expanded at an average speed of about 200 ms[SUP]-1[/SUP]during the first hours after the event. It reached stagnation distance of 25000 km about 3 days after impact. The pre-impact dust jet and fan activity (`porcupine' pattern) remained undisturbed after impact. In our measurements the jet activity can be traced to a few 100 km nucleus distance. In total 9 comastructures are identified which may originate from at least 4 regions of enhanced dust emission on the nucleus - one of this region may in fact be multiple. No obvious signatures of a new active region created by DI are found. The overall dust production during the impact compares to about 5-10 h of normal activity. The global expansion geometry of the DI cloud is compatible with a majority of dust grains in the micron size range. Indications exist for asymmetric brightness and colour distributions of the dust in the ejecta cloud. The dust temperature rose from about 280-290 K before to 330 K one day after the event and fell to pre-impact level the day thereafter. The dust reflected sunlight was found to be linearly polarized at about 7.5% in the visible and near-IR, at constant level within about 4000 km from the nucleus. No circular polarization of the dust is detected. [less ▲]

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See detailESO Spectrophotometry of Comet 9P/Tempel 1
Weiler, M.; Rauer, H.; Sterken, C. et al

in Käufl, H. U.; Sterken, C. (Eds.) Deep Impact as a World Observatory Event: Synergies in Space, Time, and Wavelength (2009)

The Deep Impact target comet 9P/Tempel 1 was observed by means of long-slit spectroscopy from two nights before impact up to eight nights after impact, using the ESO VLT UT1, UT2, and ESO NTT telescopes ... [more ▼]

The Deep Impact target comet 9P/Tempel 1 was observed by means of long-slit spectroscopy from two nights before impact up to eight nights after impact, using the ESO VLT UT1, UT2, and ESO NTT telescopes. Spectra covering the complete optical wavelength range were obtained, and information at different position angles in the coma was collected. The data were used to study the gas and dust activity of comet 9P/Tempel 1. Gas production rates before and after impact and the amount of material in the impact cloud were determined. The pre-impact Afρ parameter, the dust production rate and the dust-to-gas mass ratio were derived. A variation of the cometary gas activity with rotation of the nucleus was detected. A difference in the variation of the brightness of the CN gas emission band compared to the variation of the emissions by C_2, C_3, and NH_2 in the inner coma suggests compositional differences between different parts of the surface of comet 9P/Tempel 1's nucleus. [less ▲]

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See detailFiche synthétique de gestion: Les Jussies
Delbart, Emmanuel ULiege; Mahy, Grégory ULiege

Learning material (2009)

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See detailInfluence of environmental conditions on the interfacial organisation of fengycin, a bioactive lipopeptide produced by Bacillus subtilis
Eeman, Marc; Pegado, Luis; Dufrene, Yves F. et al

in Journal of Colloid & Interface Science (2009), 329(2), 253-264

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See detailL'image du mois. Melanome a croissance rapide.
Bourguignon, Raphaël; Giet-Lesuisse, Marianne; Arrese Estrada, Jorge ULiege et al

in Revue Médicale de Liège (2009), 64(9), 429-31

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See detailRoad Pricing as an Impetus for Environment-Friendly Travel Behavior: Results from a Stated Adaptation Experiment
Janssens, Davy; Cools, Mario ULiege; Moons, Elke et al

in Transportation Research Record: Journal of the Transportation Research Board (2009), 2115

An important policy instrument for governments to modify travel behavior and manage the increasing travel demand is the introduction of a congestion pricing system. In this study, the influence of a ... [more ▼]

An important policy instrument for governments to modify travel behavior and manage the increasing travel demand is the introduction of a congestion pricing system. In this study, the influence of a detailed classification of activities is examined to assess likely traveler response to congestion pricing scenarios. Despite the fact that most studies do not differentiate between activity categories, the value of time and in general the space–time properties and constraints of different types of activities vary widely. For this reason, it is of importance to provide sufficient detail and sensitivity in assessing the impact of congestion pricing scenarios. In addition, a first assessment of travelers’ possible multifaceted adaptation patterns is presented. For these purposes, a stated adaptation study was conducted in Flanders, the Dutch-speaking region of Belgium. The experiment was conducted through an interactive stated adaptation survey. In the stated adaptation experiment, respondents could indicate their responses to the congestion pricing scenario. The most prevalent conclusion is that the activity type significantly predetermines the willingness to express a more environment-friendly behavior (i.e., reducing the number of trips, reducing the total distance traveled, switching to more environment-friendly modes). Also, the willingness to show ecological activity-travel behavior (e.g., carpooling and using public transport) in a nonpricing situation is a major differentiator of future behavior in a congestion pricing scenario. [less ▲]

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See detailComa, consciousness and the brain
Noirhomme, Quentin ULiege

Conference (2009)

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See detailQuoi de neuf dans le Syndrome Douleur Régional Complexe (SDRC) encore appelé algoneurodystrophie
Fontaine, Robert ULiege; Teuwis, Sandrine ULiege; Faymonville, Marie ULiege

in Douleur et Analgésie (2009), 22

Complex regional pain syndrome (CRPS) remains difficult to understand and to treat. The definition criteria of the IASP (International Association for the Study of Pain) in 1994 showed an overestimation ... [more ▼]

Complex regional pain syndrome (CRPS) remains difficult to understand and to treat. The definition criteria of the IASP (International Association for the Study of Pain) in 1994 showed an overestimation of diagnosis. A revision of these criteria conducted in Budapest in 2003 permits to ameliorate the specificity of these criteria in clinical and research settings. Pathophysiology is poorly understood, only one mechanism can’t explain the observed manifestations in the CRPS: facilitated neurogenic inflammation, peripheral and central abnormalities of the central nervous system … Finally, the different laboratory tests are reviewed. Unfortunately, no laboratory test is the signature of CRPS. The diagnosis relies on history and rigorous clinical examination. Imagery method, neurophysiologic test and evaluation of inflammatory parameters help to the differential diagnosis. [less ▲]

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See detailHistological study of the sex-change in the skunk clownfish Amphiprion akallopisos
Casadevall, Margarida; Delgado, E.; Colleye, Orphal ULiege et al

in Open Fish Science Journal (2009), 2

Sex change in the protandrous fish Amphiprion akallopisos Bleeker, 1853 (F.Pomacentridae) has been analysed. Experiments consisted of placing males together after being separated from their mates, and ... [more ▼]

Sex change in the protandrous fish Amphiprion akallopisos Bleeker, 1853 (F.Pomacentridae) has been analysed. Experiments consisted of placing males together after being separated from their mates, and observe changes in gonad histology at different periods, in order to identify signs of the sex change process. The presence of a first invagination on the male gonad wall, and the observation of the first cortical alveoli oocytes as an indication of the beginning of the vitellogenesis process, was the first symptom of the sex change, which has been detected after 18 days in one of the males. Period needed for the sex changing process was size independent. The process by which wall invagination is converted into ovarian lumen in the future mature ovary is also described. [less ▲]

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