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See detailRelationship between Change in Femoral Neck Bone Mineral Density and Hip Fracture Incidence During Treatment with Strontium Ranelate
Bruyère, Olivier ULiege; Roux, Christian; Badurski, J. et al

in Current Medical Research & Opinion (2007), 23(12), 3041-5

OBJECTIVE: Strontium ranelate (SR) increases bone mineral density (BMD) in postmenopausal osteoporotic women and reduces vertebral and non-vertebral fracture incidence. Hip fracture reduction has also ... [more ▼]

OBJECTIVE: Strontium ranelate (SR) increases bone mineral density (BMD) in postmenopausal osteoporotic women and reduces vertebral and non-vertebral fracture incidence. Hip fracture reduction has also been observed during 3-year treatment with SR in osteoporotic women at high risk of hip fracture. The objective of this study is to analyse the association between BMD changes and hip fracture incidence during treatment with SR. MATERIAL AND METHODS: In this post-hoc analysis, 465 women aged over 74 years with low BMD at the femoral neck (T-score < or = -2.4 according to NHANES normative values) were selected from the population of a recently published study (the Treatment of Peripheral Osteoporosis Study - TROPOS). BMD was assessed at the femoral neck at baseline and after a follow-up of 3 years. Hip fractures were reported by study investigators. RESULTS: After adjusting for age, body mass index, femoral neck BMD at baseline and number of prevalent vertebral fractures, we found that for each 1% increase in femoral neck BMD observed after 3 years, the risk to experience a hip fracture after 3 years decreased by 7% (95% CI: 1-14%) (p = 0.04). In patients experiencing a hip fracture over 3 years of treatment with SR, femoral neck BMD increased by (mean [SE]) 3.41 (1.02)% compared to 7.23 (0.81)% in patients without hip fracture (p = 0.02). CONCLUSION: In this post-hoc analysis of women undergoing 3 years of SR treatment, an increase in femoral neck BMD is associated with a decrease in hip fracture incidence. [less ▲]

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See detailIntravenous iron therapy restores functional iron deficiency induced by infliximab
Katsanos, Konstantinos; Cavalier, Etienne ULiege; Ferrante, Marc et al

in Journal of Crohn’s and Colitis [=JCC] (2007), 1

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See detailLa circonscription fédérale : un placebo administré à un malade incurable?
Bouhon, Frédéric ULiege

E-print/Working paper (2007)

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See detailDe distributie van goederen en de licentieovereenkomst
Vanbrabant, Bernard ULiege; Van Couter, Yves

in Bestendig Handboek Distributierecht (2007)

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See detailIdentification of accessible human cancer biomarkers using ex vivo chemical proteomic strategies
Kischel, Philippe ULiege; Waltregny, David ULiege; Castronovo, Vincenzo ULiege

in Expert Review of Proteomics (2007), 4(6), 727-739

One promising avenue towards the development of more selective, better anticancer drugs lies in the targeted delivery of bioactive compounds to the tumor environment by means of binding molecules specific ... [more ▼]

One promising avenue towards the development of more selective, better anticancer drugs lies in the targeted delivery of bioactive compounds to the tumor environment by means of binding molecules specific for tumor-associated biomarkers. Eligibility of such markers for therapeutic ideally use three criteria: accessibility from the bloodstream; expression at sufficient level, and no (or much lower) expression in normal tissues. Most current discovery strategies (such as biomarker searching into body fluids) provide no clue as to whether proteins of interest are accessible, in human tissues, to suitable high-affinity ligands, such as systemically delivered monoclonal antibodies. To address this limitation, our group recently developed two methodologies based on chemical proteomic modifications, enabling the discovery of proteins accessible from the bloodstream and the extracellular space in human pathological tissues. In this review, we will discuss the potential benefits of these methodologies for the fast discovery of therapeutically valuable biomarkers. [less ▲]

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See detailInhibition of tumor growth and metastasis establishment by adenovirus-mediated gene transfer delivery of the antiangiogenic factor 16K hPRL
Nguyen, Ngoc-Quynh-Nhu ULiege; Cornet, Anne ULiege; Blacher, Silvia ULiege et al

in Molecular Therapy : The Journal of the American Society of Gene Therapy (2007), 15(12), 2094-2100

Tumor metastases, the most fearsome aspect of cancer, are generally resistant to conventional therapies. Angiogenesis is a crucial aspect of tumor growth and metastatic dissemination. Antiangiogenic ... [more ▼]

Tumor metastases, the most fearsome aspect of cancer, are generally resistant to conventional therapies. Angiogenesis is a crucial aspect of tumor growth and metastatic dissemination. Antiangiogenic therapy, therefore, holds potential as an attractive strategy for inhibiting metastasis development. Human 16K PRL (16K hPRL), a potent inhibitor of angiogenesis, has been demonstrated to prevent tumor growth in two xenograft mouse models, but whether it also affects tumor metastasis is unknown. In this study we will investigate the ability of 16K hPRL to prevent the establishment of metastasis. We demonstrate that 16K hPRL administered via adenovirus-mediated gene transfer, inhibits tumor growth by 86% in a subcutaneous (SC) B16-F10 mouse melanoma model. Computer-assisted image analysis shows that 16K hPRL treatment results in a reduction of tumor-vessel length and width, leading to a 57% reduction of average vessel size. In a pre-established tumor model, moreover, 16K hPRL can significantly delay tumor development. Finally, for the first time, we provide evidence that 16K hPRL considerably reduces the establishment of B16-F10 metastasis in an experimental lung metastasis model. Both the number and size of metastases are reduced by 50% in 16K hPRL-treated mice. These results highlight a potential role for 16K hPRL in anticancer therapy for both primary tumors and metastases. [less ▲]

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See detailEtude comparative des performances de production laitiere de brebis de race Mouton Laitier Belge avec celles de brebis de race Lacaune.
Gillon, Alain ULiege; Rondia, Pierre; Gengler, Nicolas ULiege et al

in 14ièmes Recontres Recherches Ruminants, Paris, les 5 et 6 Décembre 2007 (2007, December)

La Wallonie compte une dizaine de producteurs de lait de brebis avec un cheptel variant de 30 à 250 individus par exploitation, pour la plupart de race « Mouton Laitier Belge » (MLB). Il s’agit d’un ... [more ▼]

La Wallonie compte une dizaine de producteurs de lait de brebis avec un cheptel variant de 30 à 250 individus par exploitation, pour la plupart de race « Mouton Laitier Belge » (MLB). Il s’agit d’un animal de type exclusivement laitier qui s’apparente fortement au mouton laitier frison dont l’effectif s’élève à un millier de têtes. La présence simultanée de brebis Lacaune (LAC) et de brebis MLB sur une même exploitation a permis la comparaison de leurs performances respectives grâce à une maîtrise du facteur « mode de conduite ». L’effectif restreint des populations étudiées constitue une limite à une extrapolation des résultats à l’ensemble des individus des races concernées mais donne néanmoins une certaine indication de leur potentiel de production respectif en région wallonne. [less ▲]

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See detailLabor et Complexe, c'est fini
Habrand, Tanguy ULiege

Article for general public (2007)

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See detailUn label pour la librairie indépendante
Habrand, Tanguy ULiege

Article for general public (2007)

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See detailA Hybrid Systems Approach to Trajectory Tracking Control for Juggling Systems
Sanfelice, Ricardo G.; Teel, Andrew R.; Sepulchre, Rodolphe ULiege

in Proceedings of the 46th IEEE Conference on Decision and Control (2007, December)

From a hybrid systems point of view, we provide a modeling framework and a trajectory tracking control design methodology for juggling systems. We present the main ideas and concepts in a one degree-of ... [more ▼]

From a hybrid systems point of view, we provide a modeling framework and a trajectory tracking control design methodology for juggling systems. We present the main ideas and concepts in a one degree-of-freedom juggler, which consists of a ball bouncing on an actuated robot. We design a hybrid control strategy that, with only information of the ball’s state at impacts, controls the ball to track a reference rhythmic pattern with arbitrary precision. We extend this hybrid control strategy to the case of juggling multiple balls with different rhythmic patterns. Simulation results for juggling of one and three balls with a single actuated robot are presented. [less ▲]

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See detailDu « capital social » à l’utilité sociale : Petite étude sur le lien social chez les personnes précarisées
Italiano, Patrick ULiege

Book published by Editions de l'ULG (2007)

Etude de l'évolution du lien social au cours du parcours de vie de personnes en précarité aiguë

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See detailAlternating Spatial Patterns for Coordinated Group Motion
Swain, Daniel T.; Leonard, Naomi Ehrich; Couzin, Iain D. et al

in Proceedings of the 46th IEEE Conference on Decision and Control (2007, December)

Abstract—Motivated by recent observations of fish schools, we study coordinated group motion for individuals with oscillatory speed. Neighbors that have speed oscillations with common frequency, amplitude ... [more ▼]

Abstract—Motivated by recent observations of fish schools, we study coordinated group motion for individuals with oscillatory speed. Neighbors that have speed oscillations with common frequency, amplitude and average but different phases, move together in alternating spatial patterns, taking turns being towards the front, sides and back of the group. We propose a model and control laws to investigate the connections between these spatial dynamics, communication when sensing is range or direction limited, and convergence of coordinated group motions. [less ▲]

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See detailAn Arbitrary Lagrangian Eulerian Formulation for the Numerical Simulation of Forming Processes
Boman, Romain ULiege; Papeleux, Luc ULiege; Ponthot, Jean-Philippe ULiege

in International Workshop 2007: Advancements in Design Optimization of Materials, Structures and Mechanical Systems (2007, December)

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See detailStabilization of Collective Motion in Three Dimensions : A Consensus Approach
Scardovi, Luca; Leonard, Naomi; Sepulchre, Rodolphe ULiege

in Proceedings of 46th IEEE Conference on Decision and Control (2007, December)

This paper proposes a methodology to stabilize relative equilibria in a model of identical, steered particles moving in three- dimensional Euclidean space. Exploiting the Lie group structure of the ... [more ▼]

This paper proposes a methodology to stabilize relative equilibria in a model of identical, steered particles moving in three- dimensional Euclidean space. Exploiting the Lie group structure of the resulting dynamical system, the stabilization problem is reduced to a consensus problem on the Lie algebra. The resulting equilibria correspond to parallel, circular and helical formations. We rst derive the stabilizing control laws in the presence of all-to-all communication. Providing each agent with a consensus estimator, we then extend the results to a general setting that allows for unidirectional and time-varying communication topologies. [less ▲]

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See detailConsensus under general convexity
tuna, S. E.; Sepulchre, Rodolphe ULiege

in Proceedings of the 46th IEEE Conference on Decision and Control (2007, December)

A method is proposed to characterize contraction of a set through orthogonal projections. For discrete-time multi-agent systems, quantitative estimates of convergence (to a consensus) rate are provided by ... [more ▼]

A method is proposed to characterize contraction of a set through orthogonal projections. For discrete-time multi-agent systems, quantitative estimates of convergence (to a consensus) rate are provided by means of contracting convex sets. Required convexity for the sets that should include the values that the transition maps of agents take is considered in a more general sense than that of Euclidean geometry. [less ▲]

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See detailPredatory boreholes in Tournaisian (Lower Carboniferous) spiriferid brachiopods
Mottequin, Bernard ULiege; Sevastopulo, George

in Budd, G. E.; Streng, M.; Daley, A. C. (Eds.) et al Programme with abstracts of the 51st Palaeontological Association Annual Meeting (2007, December)

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