References of "2003"
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See detailValidation of two homologous radioimmunoassays for measuring pregnancy-associated glycoprotein in ewes.
El Amiri, B.; Karen, A.; Sulon, J. et al

in Reproduction in Domestic Animals (2003), 38(4), 358

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See detailL'interscripteur et le rhapsode
Servais, Christine ULiege

in Parouty-David, Françoise; Zilberberg, Claude (Eds.) Sémiotique et esthétique (2003)

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See detailThe impact of reimbursement criteria on the appropriateness of 'statin' prescribing.
Autier, Philippe; Creplet, Jean; Vansant, Greet et al

in European Journal of Cardiovascular Prevention & Rehabilitation (2003), 10(6), 456-62

BACKGROUND: In Belgium, regulations restrict the reimbursement of statins to patients with total serum cholesterol above 250 mg/dl (6.41 mmol/l) after a three-month lipid-lowering diet. We investigated ... [more ▼]

BACKGROUND: In Belgium, regulations restrict the reimbursement of statins to patients with total serum cholesterol above 250 mg/dl (6.41 mmol/l) after a three-month lipid-lowering diet. We investigated the possible impact of these regulations on characteristics of Belgian patients receiving a lipid-lowering drug. DESIGN: From 1998 to 2000, standard questionnaires on coronary risk factors and treatments with lipid-lowering drugs were completed by 301 GPs sampled at random in the 11 Belgian Provinces. Questionnaires had to be completed for 18 consecutive patients 35 years old or more attending GPs' practices, irrespective of the underlying motive for attendance. RESULTS: Of the 5511 patients included in the study, 1519 (28%) had established coronary disease or diabetes mellitus, or > or = 2 non-cholesterol coronary risk factors. Most (70%) of these patients were not treated with a lipid-lowering drug. Only 22% of patients with established coronary disease, 10% of patients with diabetes mellitus and 9% of patients with > or = 2 coronary risk factors were treated with a statin. Fifty-nine percent of fibrate users and 50% of statin users had a pre-treatment cholesterol level above 250 mg/dl, but had no or only one non-cholesterol coronary risk factor. CONCLUSIONS: In Belgium, the majority of patients at higher risk of coronary event do not benefit from lipid-lowering drugs, particularly the statins. In contrast, one of two statin users and three of five fibrate users should probably not receive the drug prescribed. Regulation based on blood cholesterol level encourages the overlooking of other risk factors relevant for selecting patients having the greatest chance to benefit from statin treatment. [less ▲]

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See detailRequiem pour le monde ancien
Denis, Benoît ULiege

in Swennen, René (Ed.) Les Trois Frères (2003)

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See detailPhosphate mineral occurrences in Lake Baïkal sediments : Paleo-environment or diagenesis record ?
Fagel, Nathalie ULiege; Alleman, L. Y.; André, Luc et al

Poster (2003)

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See detailTime-dependent behaviour of oil reservoir chalk: A multiphase approach
De Gennaro, Vincenzo; Delage, Pierre; Cui, Yu Jun et al

in Soils and Foundations (2003), 43(4),

In the North Sea Ekofisk oilfield, oil is located in a 300 m thick layer of porous chalk (n = 40-50%) at a 3000 m depth. After the initial phase of depletion an enhanced oil recovery procedure was carried ... [more ▼]

In the North Sea Ekofisk oilfield, oil is located in a 300 m thick layer of porous chalk (n = 40-50%) at a 3000 m depth. After the initial phase of depletion an enhanced oil recovery procedure was carried out by injecting sea water (waterflooding). An unexpected consequence of this waterflooding has been the occurrence of a seafloor subsidence, corresponding up to now to a decrease of the seafloor level of approximately 10 m. It is now well recognised that hydro-mechanical coupling involving multiphase fluid interactions (oil and water) is determinant for the interpretation of the phenomenological aspects associated with the chalk compaction and the related subsidence observed in the North Sea oilfields (Ekofisk reservoir) when water flooded. The subsidence due to waterflooding is interpreted as a collapse phenomenon due to suction decrease, typical of loose and low plasticity unsaturated soils when wetted under load. On the other hand, time-dependent stress-strain behaviour of geomaterials is one of the major concerns in soil mechanics and, in effect, subsidence includes creep effects. A multiphase approach, including creep effects under controlled suction levels, is proposed in this paper; the preliminary results of this study are presented and discussed. Attention will be focused at first on the theoretical approach, supplying the essential elements for the work, and on the interpretation of the experimental results. This will provide secondly the base for formulation and validation of the constitutive law proposed for the description of the time-dependent mechanical behaviour of the chalk. [less ▲]

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See detailAirborne pulse-Doppler radar and early forms of radar space-time processing
Verly, Jacques ULiege

Scientific conference (2003)

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See detailComparison of change in bone resorption and bone mineral density with once-weekly alendronate and daily risedronate: a randomised, placebo-controlled study
Hosking, D.; Adami, S.; Felsenberg, D. et al

in Current Medical Research & Opinion (2003), 19(5), 383-394

Objective: To compare the effects of alendronate (ALN) 70 mg once weekly (OW) and risedronate (RIS) 5 mg daily between-meal dosing on biochemical markers of bone turnover and bone mineral density (BMD) in ... [more ▼]

Objective: To compare the effects of alendronate (ALN) 70 mg once weekly (OW) and risedronate (RIS) 5 mg daily between-meal dosing on biochemical markers of bone turnover and bone mineral density (BMD) in postmenopausal women with osteoporosis. Research design and methods: This was a 3-month, randomised, double-blind, placebo-controlled study with a double-blind extension to 12 months. The study enrolled 549 postmenopausal women (ALN 219, RIS 222 and placebo (PBO) 108) who were : 60 years of age at outpatient centres. Main outcome measures: The primary endpoint was reduction in urine N-telopeptides of type 1 collagen (NTx) corrected for creatinine level at 3 months. Secondary parameters included change in BMD at the spine and hip at 6 and 12 months, NTx at 1, 6 and 12 months, and serum bone-specific alkaline phosphatase (BSAP) at 1, 3, 6 and 12 months. Adverse experiences (AEs) were recorded throughout the study for an assessment of treatment safety profiles and tolerability. Results: Over 3 months, ALN produced a significantly greater mean reduction in urine NTx than did RIS (-52% vs -32%, p < 0.001), which was maintained at 12 months. ALN produced a significantly greater mean BMD increase than did RIS at 6 months, and it was maintained at 12 months at the lumbar spine (4.8% vs 2.8%, p < 0.001) and total hip (2.7% vs 0.9%, p < 0.001), as well as at the trochanter and femoral neck. Significant reductions in BSAP with ALN compared to RIS were maintained over the 12 months of treatment. Study size did not allow for meaningful assessment of differences in fracture rates. Tolerability was generally similar between ALN, RIS and PBO, and the incidence of upper GI AEs causing discontinuation and oesophageal AEs was similar in the ALN and RIS groups. Conclusion: In this study, ALN 70 mg OW produced a 50% greater reduction in bone resorption as measured by urine NTx and significantly greater increases in lumbar spine and hip BMD than did RIS 5 mg daily. The treatments had similar safety profiles and were generally well-tolerated. Additional studies are needed comparing OW ALN with OW RIS, which became available after the commencement of the present study. [less ▲]

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See detailLa Vie de saint Lambert du chanoine Nicolas (ca 1145) et l’élection du prince-évêque Henri de Leez (1145-1162)
Adam, Renaud ULiege

in Bulletin de l'Institut Archéologique Liégeois (2003), 111

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See detailPregnancy-Associated Glycoprotein 60f [Fragment] from Ovis aries placenta - Access number P83498
El Amiri, B.; Remy, B.; Melo de Sousa, Noelita ULiege et al

E-print/Working paper (2003)

N-terminal microsequence obtained after purification and characterization of placental proteins in ovine species. Proteins were submitted to SwissProt databank.

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See detailLes OGM sous l'angle économique
Burny, Philippe ULiege

Conference given outside the academic context (2003)

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See detailPhosphate mineral formation in Lake Baïkal sediments and implications for paleoclimate
Fagel, Nathalie ULiege; Alleman, L. Y.; André, Luc et al

Poster (2003)

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See detailLa qualité différenciée
Burny, Philippe ULiege

in Centre de Recherches agronomiques de Gembloux (CRA) (Ed.) 3ème journée Productions porcines et avicoles "Vers une politique de qualité, à quel prix ?", Gembloux, 8 octobre 2003 (2003)

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See detailVascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas.
Munaut, Carine ULiege; Noël, Agnès ULiege; Hougrand, Olivier ULiege et al

in International Journal of Cancer = Journal International du Cancer (2003), 106(6), 848-55

Vascular endothelial growth factor (VEGF) is the major endothelial mitogen in central nervous system neoplasms and it is expressed in 64-95% of glioblastomas (GBMs). Tumour cells are the main source of ... [more ▼]

Vascular endothelial growth factor (VEGF) is the major endothelial mitogen in central nervous system neoplasms and it is expressed in 64-95% of glioblastomas (GBMs). Tumour cells are the main source of VEGF in GBMs whereas VEGF receptors (VEGFR-1, its soluble form sVEGFR-1, VEGFR-2 and neuropilin-1) are expressed predominantly by endothelial cells. Infiltrating tumour cells and newly-formed capillaries progress through the extracellular matrix by local proteolysis involving matrix metalloproteinases (MMPs). Recent studies have shown that VEGF expression and bioavailability can be modulated by MMPs. We reported previously that the expression of MT1-MMP in human breast cancer cells was associated with an enhanced VEGF expression. We used quantitative RT-PCR, Western blot, gelatin zymography and immunohistochemistry to study the expression of VEGF, VEGFR-1, VEGFR-2, sVEGFR-1, neuropilin-1, MT1-MMP, MMP-2, MMP-9 and TIMP-2 in 20 human GBMs and 5 normal brains. The expression of these MMPs was markedly increased in most GBMs with excellent correlation between mRNA and protein levels; activated forms of MMP-2 and MMP-9 were present in 8/18 and 7/18 of GBMs. A majority of GBMs (17/20) also expressed high levels of VEGF, as previously reported, with strong correlation between VEGF and MT1-MMP gene expression levels, and double immunostaining showed that VEGF and MT1-MMP peptides co-localize in tumour and endothelial cells. Our results suggest that the interplay between metalloproteinases and VEGF previously described in experimental tumours may also be operative in human GBMs. Because of its dual ability to activate MMP-2 and to up-regulate VEGF, MT1-MMP might be of central importance in the growth of GBMs and represent an interesting target for anti-cancer treatments. [less ▲]

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See detailMagnetic fabrics in the Holum granite (Vest-Agder, southernmost Norway): implications for the late evolution of the Sveconorwegian (Grenvillian) orogen of SW Scandinavia
Bolle, Olivier ULiege; Diot, Hervé; Trindade, Ricardo I.F.

in Precambrian Research (2003), 121(3-4), 221-249

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See detailEpidemiology, clinical presentation and diagnostic strategy of gastro-esophageal reflux
Louis, Edouard ULiege

in Acta Endoscopica (2003), 33

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See detailPregnancy-associated glycoprotein concentrations in plasma and milk samples for early pregnancy diagnosis in Lacaune dairy sheep.
El Amiri, B.; Cognié, Y.; Sulon, J. et al

in Reproduction in Domestic Animals (2003), 38(4), 322

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See detailOptimal processing of STAP signals, its interpretations and its numerical requirements
Verly, Jacques ULiege

Scientific conference (2003)

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See detailMolecular basis of the cold adaptation of enzymes
D'Amico, Salvino ULiege

Scientific conference (2003)

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