References of "Maquet, Pierre"
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See detailAnti-SOX1 antibody-associated acute hemorrhagic leukoencephalitis
Lambert, Nicolas ULiege; LUTTERI, Laurence ULiege; TSHIBANDA, Luaba ULiege et al

in Journal of Neurology (2022)

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See detailEvaluating the effects of tDCS in stroke patients using functional outcomes: a systematic review
Bornheim, Stephen ULiege; Thibaut, Aurore ULiege; Beaudart, Charlotte ULiege et al

in Disability and Rehabilitation (2022), 44(1), 13-23

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See detailAtezolizumab Treatment for Progressive Multifocal Leukoencephalopathy
Lambert, Nicolas ULiege; Dauby, Solène ULiege; DIVE, Dominique ULiege et al

in Emerging Infectious Diseases (2022), 28(1),

Atezolizumab successfully reinvigorated JC virus immunity in a patient in Belgium with progressive multifocal leukoencephalopathy, as demonstrated by clinical, virologic, and radiologic response to ... [more ▼]

Atezolizumab successfully reinvigorated JC virus immunity in a patient in Belgium with progressive multifocal leukoencephalopathy, as demonstrated by clinical, virologic, and radiologic response to treatment. However, the treatment also resulted in immune reconstitution inflammatory syndrome and life-threatening immune-related adverse events. These conditions were treated with corticosteroids, leading to treatment resistance. [less ▲]

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See detailRepeatability of ultra-high-resolution Multi-Parametric Mapping across five 7T sites
Sherif, Siya ULiege; Aghaeifar, Ali; pine., Kerrin et al

Conference (2022)

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See detailTimely sleep coupling: phase locked slow wave - spindle pairing is linked to AD neuropathology and forecasts cognitive decline
Chylinski, Daphné ULiege; Van Egroo, Maxime; Narbutas, Justinas ULiege et al

Conference (2021, November 19)

Alteration of sleep quality is a hallmark of the ageing process. The fine-tuned coalescence of elements of sleep microstructure seems to play a pivotal role in cognitive trajectories in ageing. This may ... [more ▼]

Alteration of sleep quality is a hallmark of the ageing process. The fine-tuned coalescence of elements of sleep microstructure seems to play a pivotal role in cognitive trajectories in ageing. This may be of prime clinical importance as a bidirectional detrimental relationship between sleep quality and Alzheimer’s disease (AD) neuropathology emerges in the literature and holds promise for novel sleep related interventions. However, sleep is not yet established as a true risk factor for AD, most likely because the understanding of its core associations with AD neuropathology remains insufficient. In this context, we focused on the timely coupling of two key graphoelements of Non-Rapid Eye Movement (NREM) sleep that is slow waves and spindles, and their associations with AD neuropathology and cognition. We show, in a detailed large dataset (N=100; 68 woman) of undisturbed sleep recorded in late middle-aged healthy individuals (50 to 70y; 60 +- 5), that the precise coupling of sleep spindles with a specific category of sleep slow waves, those deemed most important for memory consolidation, is associated to lower medial prefrontal cortex PET-scan β-Amyloid burden, a landmark of AD neuropathology (F1,96=6.2, p=0.014). Cruder aspects of sleep macrostructure and sleep intensity were, however, not significantly linked to β-Amyloid burden in this relatively young sample with low β-Amyloid deposit. We further show that this specific coupling is predictive of a lower memory decline, assessed over 2 years using a task highly sensitive to the first signs of memory impairment (F1,54=4.67, p=0.035). These findings unravel early links between sleep, AD-related and cognitive trajectories in ageing and suggest that altered coupling of sleep microstructure elements key to its functions could constitute the first association with AD neuropathology and that less refined measures of sleep macrostructure or sleep intensity may only be significantly associated to AD neuropathology later in life, when β-amyloid burden is higher. Sleep microstructure integrity could therefore constitute a potential indicator of a less successful ageing trajectory. [less ▲]

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See detailAlzheimer’s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness
Muto, Vincenzo ULiege; Koshmanova, Ekaterina ULiege; Ghaemmaghami Tabrizi, Pouya ULiege et al

in Sleep (2021), 44(1), 137

Study objectives: Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer's disease. Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD ... [more ▼]

Study objectives: Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer's disease. Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young adults, decades before typical AD symptom onset. Methods: We computed whole-genome Polygenic Risk Scores (PRS) for AD and extensively phenotyped sleep under different sleep conditions, including baseline sleep, recovery sleep following sleep deprivation and extended sleep opportunity, in a carefully selected homogenous sample of healthy 363 young men (22.1 y ± 2.7) devoid of sleep and cognitive disorders. Results: AD PRS was associated with more slow wave energy, i.e. the cumulated power in the 0.5-4 Hz EEG band, a marker of sleep need, during habitual sleep and following sleep loss, and potentially with large slow wave sleep rebound following sleep deprivation. Furthermore, higher AD PRS was correlated with higher habitual daytime sleepiness. Conclusions: These results imply that sleep features may be associated with AD liability in young adults, when current AD biomarkers are typically negative, and the notion that quantifying sleep alterations may be useful in assessing the risk for developing AD. [less ▲]

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See detailImmune checkpoint inhibitors for progressive multifocal leukoencephalopathy: identifying relevant outcome factors
Lambert, Nicolas ULiege; El Moussaoui, Majdouline ULiege; MAQUET, Pierre ULiege

in European Journal of Neurology (2021)

Introduction: Progressive multifocal leukoencephalopathy (PML) is an infectious brain disease caused by JC virus in immunocompromised individuals. Immune checkpoint inhibitors (ICIs) recently emerged as a ... [more ▼]

Introduction: Progressive multifocal leukoencephalopathy (PML) is an infectious brain disease caused by JC virus in immunocompromised individuals. Immune checkpoint inhibitors (ICIs) recently emerged as a therapeutic hope for these patients but identification of those likely to respond to the treatment is still an unmet need. Method: We performed a systematic PubMed search for reports of patients treated for PML using an ICI. Clinical, biological and radiological characteristics were contrasted between patients who responded to the treatment (RP) and those who did not (NRP). Results: 35 patients were included in the present study. 21 of them reportedly benefited from the treatment. Age, blood CD4+ cells count, pre-treatment viral load in the cerebrospinal fluid (CSF), PML lesions localization, treatment delay since first PML symptoms, type of ICI used and immune-related adverse events (irAEs) occurrence did not significantly differ between RP and NRP. By contrast, a history of therapeutic immune suppression and the use of an immunosuppressive therapy at treatment initiation were significantly associated with a poor response. Besides, reaching an undetectable viral load the CSF and reduction of the lesion load on magnetic resonance imaging after ICI administration were associated with a good clinical response. Conclusion: Current data suggest that patients with PML under immunosuppressive therapy are less likely to respond to ICIs and raise the issue of the optimal management of irAEs during ICI treatment in this setting. [less ▲]

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See detailParkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI
DEPIERREUX, Frédérique ULiege; PARMENTIER, Eric ULiege; MACKELS, Laurane ULiege et al

in NPJ Parkinson's Disease (2021)

Parkinson’s disease is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin-containing dopaminergic neurons and deposition of iron in the substantia nigra (SN). How ... [more ▼]

Parkinson’s disease is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin-containing dopaminergic neurons and deposition of iron in the substantia nigra (SN). How regional neuromelanin (NM) loss and iron accumulation within specific areas of SN relates to nigro-striatal dysfunction needs to be clarified. We measured dopaminergic function in pre- and post-commissural putamen by [18F]DOPA PET in twenty-three Parkinson’s disease (PD) patients and 23 healthy control (HC) participants in whom NM content and iron load was assessed in medial and lateral SN, respectively by neuromelanin-sensitive and quantitative R2* MRI. Data analysis consisted of voxelwise regressions testing the group effect and its interaction with NM or iron signals. In PD patients, R2* was selectively increased in left lateral SN as compared to healthy participants, suggesting a local accumulation of iron in Parkinson’s disease. By contrast, NM signal differed between PD and HC, without specific regional specificity within SN. Dopaminergic function in posterior putamen decreased as R2* increased in lateral SN, indicating that dopaminergic function impairment progresses with iron accumulation in the SN. Dopaminergic function was also positively correlated with NM signal in lateral SN, indicating that dopaminergic function impairment progresses with depigmentation in the SN. A complex relationship was detected between R2* in the lateral SN and NM signal in the medial substantia nigra. In conclusion, multimodal imaging reveals regionally-specific relationships between iron accumulation and depigmentation within the SN of Parkinson’s disease and provides in vivo insights in its neuropathology. [less ▲]

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See detailExploratory radiomic analysis of conventional versus quantitative brain MRI: Towards automatic diagnosis of early multiple sclerosis
Lavrova, Elizaveta ULiege; LOMMERS, Emilie ULiege; WOODRUFF, Henry et al

in Frontiers in Neuroscience (2021)

Conventional magnetic resonance imaging (cMRI) is poorly sensitive to pathological changes related to multiple sclerosis (MS) in normal-appearing white matter (NAWM) and grey matter (GM), with the added ... [more ▼]

Conventional magnetic resonance imaging (cMRI) is poorly sensitive to pathological changes related to multiple sclerosis (MS) in normal-appearing white matter (NAWM) and grey matter (GM), with the added difficulty of not being very reproducible. Quantitative MRI (qMRI) on the other hand attempts to represent physical properties of tissues, making it an ideal candidate for quantitative medical image analysis, or radiomics. We therefore hypothesized that qMRI-based radiomic features have added diagnostic value in MS compared to cMRI. This study investigated the ability of cMRI (T1w) and qMRI features extracted from WM, NAWM, and GM to distinguish between MS patients (MSP) and healthy control subjects (HCS). We developed exploratory radiomic classification models on a dataset comprising 36 MSP and 36 HCS recruited in CHU Liege, Belgium, acquired with cMRI and qMRI. For each image type and region of interest, qMRI radiomic models for MS diagnosis were developed on a training subset and validated on a testing subset. Radiomic models based on cMRI were developed on the entire training dataset and externally validated on open-source datasets with 167 HCS and 10 MSP. Ranked by region of interest, the best diagnostic performance was achieved in the whole WM. Here the model based on magnetization transfer imaging (a type of qMRI) features yielded a median area under the receiver operating characteristic curve (AUC) of 1.00 in the testing sub-cohort. Ranked by image type, the best performance was achieved by the magnetization transfer models, with median AUCs of 0.79 (0.69-0.90 90% CI) in NAWM and 0.81 (0.71-0.90) in GM. External validation of the T1w models yielded an AUC of 0.78 (0.47-1.00) in whole WM, demonstrating a large 95% CI and low sensitivity of 0.30 (0.10-0.70). This exploratory study indicates that qMRI Radiomics could provide efficient diagnostic information using NAWM and GM analysis in MSP. T1w radiomics could be useful for a fast and automated check of conventional MRI for WM abnormalities once acquisition and reconstruction heterogeneities have been overcome. Further prospective validation is needed involving more data for better interpretation and generalization of the results. [less ▲]

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See detailComparative study of AQP4‑NMOSD, MOGAD and seronegative NMOSD: a single‑center Belgian cohort
Dauby, Solène ULiege; DIVE, Dominique ULiege; LUTTERI, Laurence ULiege et al

in Acta Neurologica Belgica (2021)

Objectives: To emphasize physio-pathological, clinical and prognosis differences between conditions causing serious and sometimes very similar clinical manifestations: anti-aquaporin-4 (AQP4) and anti ... [more ▼]

Objectives: To emphasize physio-pathological, clinical and prognosis differences between conditions causing serious and sometimes very similar clinical manifestations: anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies related diseases, and seronegative NMOSD (neuromyelitis optica spectrum disorders). Methods: Based on diagnostic criteria for NMOSD and MOGAD (MOG associated disorders), we retrospectively surveyed 10 AQP4-NMOSD, 8 MOGAD and 2 seronegative NMOSD, followed at the specialized neuroimmunology unit of the CHU Liege. Results: Female predominance was only observed in AQP4 group. Age at onset was 37.8 and 27.7 years old for AQP4-NMOSD and MOGAD, respectively. In both groups, the first clinical event most often consisted of optic neuritis (ON), followed by isolated myelitis. Fifteen of our 20 patients encountered a relapsing course with 90% relapses in AQP4-NMOSD, 62.5% in MOGAD and 50% in the seronegative group, and a mean period between the first and second clinical event of 7.1 and 4.8 months for AQP4-NMOSD and MOGAD, respectively. In total, we counted 54 ON, with more ON per patient in MOGAD. MOG-associated ON mainly affected the anterior part of the optic nerve with a papilledema in 79.2% of cases. Despite a fairly good visual outcome after MOG-associated ON, retinal nerve fiber layer (RNFL) thickness decreased, suggesting a fragility of the optic nerve toward further attacks. Conclusion: As observed in larger cohorts, our MOGAD and AQP4-NMOSD cases differ by clinical and prognostic features. A better understanding of these diseases should encourage prompt biological screening and hasten proper diagnosis and treatment. [less ▲]

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See detailLes syndromes neurologiques paranéoplasiques
Lambert, Nicolas ULiege; LUTTERI, Laurence ULiege; SADZOT, Bernard ULiege et al

in Revue Médicale de Liège (2021), 76(5-6), 413-418

Neurological paraneoplastic syndromes are non-metastatic complications of systemic cancers, often resulting from an immune response triggered by the crossed expression of neuronal antigens by tumour cells ... [more ▼]

Neurological paraneoplastic syndromes are non-metastatic complications of systemic cancers, often resulting from an immune response triggered by the crossed expression of neuronal antigens by tumour cells. Several neurological syndromes such as cerebellar dege-neration, sensory neuronopathy, limbic encephalitis, ence-phalomyelitis or the Lambert-Eaton myasthenic syndrome are most often paraneoplastic and require prompt cancer screening, particularly if the patient shows risk factors for cancer. Although there are many exceptions to this rule, a given syndrome is often associated with a particular anti-body and the corresponding tumour. A prompt diagnosis of neurological paraneoplastic syndrome is of major impor-tance as it often reveals the underlying tumour. The treat-ment relies on both the elimination of the neoplasia and the control of the immune response. [less ▲]

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See detailThe effects of cognitive load on cognitive fatigue in Multiple Sclerosis - Preliminary results
Guillemin, Camille ULiege; Requier, Florence ULiege; Delvenne, Julie et al

Poster (2021, May 28)

Background. Cognitive fatigue is one of the most frequent and debilitating symptom of Multiple Sclerosis (MS). While it is well established that MS patients show a decrement of performances during ... [more ▼]

Background. Cognitive fatigue is one of the most frequent and debilitating symptom of Multiple Sclerosis (MS). While it is well established that MS patients show a decrement of performances during/following a long cognitive task, only few studies investigated the effects of cognitive load on MS-related fatigue. Objective. To explore the effects of cognitive load on performance decrement and pupil variations in MS. Methods. Thirteen patients with early MS (disease duration <5) and 12 matched healthy subjects performed a dual-task in cognitive load conditions (low and high). High cognitive load was adjusted to individual resources by determining the fastest presentation rate leading to at least 85% accuracy; the low cognitive load condition is 50% slower. Additionally, pupil size variations were obtained during the task for 6 patients and 7 controls. Repeated measures ANOVA were performed to determine the group, time and cognitive load effects on averaged performances and pupil size. Supplementary analysis were conducted on performances using Bayesian statistics. Results. ANOVA on performances revealed an effect of condition (F(1,20)=37.79, p<.0001) and time (F(3,20)=13.32, p<.0001) but no effect of group nor interaction effects. Bayesian statistical analysis revealed an absence of difference in performances’ evolution between groups (BF01=5.71). ANOVA for pupil size revealed a tendency to significance for the group*condition interaction (p=0.077). Discussion. MS patients did not demonstrate larger fatigue effects on performances than control when the task is adapted to individual resources. The lack of pupillary response to cognitive load seems to reflect cognitive fatigue in patients despite behavioral compensation. [less ▲]

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See detailLung and liver sarcoidosis‐like reaction induced by tocilizumab
Lambert, Nicolas ULiege; Hansen, Isabelle ULiege; El Moussaoui, Majdouline ULiege et al

in British Journal of Clinical Pharmacology (2021)

A drug‐induced sarcoidosis‐like reaction is a systemic granulomatous reaction indistinguishable from sarcoidosis and occurring in temporal relationship with a drug initiation. In this article, we report a ... [more ▼]

A drug‐induced sarcoidosis‐like reaction is a systemic granulomatous reaction indistinguishable from sarcoidosis and occurring in temporal relationship with a drug initiation. In this article, we report a patient who developed lung and liver granulomatous lesions following tocilizumab initiation for a giant cell arteritis. Infectious, toxic, neoplastic and inflammatory differential diagnoses were ruled out and lesions regressed after treatment cessation, leading to the diagnosis of tocilizumab induced sarcoidosis‐like reaction. We review the six cases reported so far and emphasize the value of a prompt diagnosis. Finally, we discuss the potential pathophysiological mechanisms underlying this rare reaction, which could help to better understand the pathophysiology of sarcoidosis. [less ▲]

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See detailCerebral functional networks during sleep in young and older individuals
Daneault, Véronique; Orban, Pierre; Martin, Nicolas et al

in Scientific Reports (2021), 11(1), 4905

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See detailVoxel-Based quantitative MRI reveals spatial patterns of grey matter alteration in multiple sclerosis
LOMMERS, Emilie ULiege; Guillemin, Camille ULiege; REUTER, Gilles ULiege et al

in Human Brain Mapping (2021), 42(4), 1003-1012

Despite robust postmortem evidence and potential clinical importance of gray matter (GM) pathology in multiple sclerosis (MS), assessing GM damage by conventional magnetic resonance imaging (MRI) remains ... [more ▼]

Despite robust postmortem evidence and potential clinical importance of gray matter (GM) pathology in multiple sclerosis (MS), assessing GM damage by conventional magnetic resonance imaging (MRI) remains challenging. This prospective cross-sectional study aimed at characterizing the topography of GM microstructural and volumetric alteration in MS using, in addition to brain atrophy measures, three quantitative MRI (qMRI) parameters—magnetization transfer (MT) saturation, longitudinal (R1), and effective transverse (R2*) relaxation rates, derived from data acquired during a single scanning session. Our study involved 35 MS patients (14 relapsing–remitting MS; 21 primary or secondary progressive MS) and 36 age-matched healthy controls (HC). The qMRI maps were computed and segmented in different tissue classes. Voxel-based quantification (VBQ) and voxelbased morphometry (VBM) statistical analyses were carried out using multiple linear regression models. In MS patients compared with HC, three configurations of GM microstructural/volumetric alterations were identified. (a) Co-localization of GM atrophy with significant reduction of MT, R1, and/or R2*, usually observed in primary cortices. (b) Microstructural modifications without significant GM loss: hippocampus and paralimbic cortices, showing reduced MT and/or R1 values without significant atrophy. (c) Atrophy without significant change in microstructure, identified in deep GM nuclei. In conclusion, this quantitative multiparametric voxel-based approach reveals three different spatially-segregated combinations of GM microstructural/volumetric alterations in MS that might be associated with different neuropathology. [less ▲]

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See detailSuccessful treatment of hand dystonia with botulinum toxin in a DYT12 patient
DEPIERREUX, Frédérique ULiege; PARMENTIER, Eric ULiege; HARDY, Pierre-Yves ULiege et al

in Toxicon (2021), 190S1(January 2021), 16

Dystonia 12 (DYT12) or rapid-onset dystonia-parkinsonism is a rare neurological disease with onset in childhood or early adulthood. The few published reports of ATP1A3-mutated patients who received ... [more ▼]

Dystonia 12 (DYT12) or rapid-onset dystonia-parkinsonism is a rare neurological disease with onset in childhood or early adulthood. The few published reports of ATP1A3-mutated patients who received pallidal surgery (deep brain stimulation or pallidotomy targeting the globus pallidus pars interna [GPi-DBS]) are disappointing as all implanted patients failed to improve. In this situation, botulinum toxin is one of the remaining options to treat focal dystonia. [less ▲]

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