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See detailDeciphering the role of the GPR101 orphan receptor in growth hormone hypersecretion
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Poster (2022, April)

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See detailDeciphering the role of the GPR101 orphan receptor in growth hormone hypersecretion
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Conference (2022, February)

Detailed reference viewed: 18 (0 ULiège)
See detailDeciphering the role of the GPR101 orphan receptor in growth hormone hypersecretion
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Poster (2021, October)

Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH secreting pituitary tumors over ... [more ▼]

Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH secreting pituitary tumors over-expressing the orphan G-protein coupled receptor, GPR101(Trivellin et al, 2014). The role of GPR101 in GH secretion remains obscure. We studied GPR101 signaling pathways and their effects in HEK293 and rat pituitary GH3 cell lines, human tumors and in transgenic mice with elevated somatotrope Gpr101 expression driven by the rat Ghrhr promoter (GhrhrGpr101). We reported that Gpr101 causes elevated GH/prolactin secretion in transgenic GhrhrGpr101 mice but without hyperplasia/tumorigenesis (Abboud et al, 2020). Furthermore, we showed that GPR101 constitutively activates not only Gs, but also Gq/11 and G12/13, which leads to GH secretion but not proliferation. These signatures of GPR101 signaling, notably PKC activation, are also present in human pituitary tumors with high GPR101 expression. These results underline a role for GPR101 in the regulation of somatotrope axis function. [less ▲]

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See detailGPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Conference (2021, April)

Detailed reference viewed: 15 (0 ULiège)
See detailGPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Conference (2021, April)

Detailed reference viewed: 7 (0 ULiège)
See detailGPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Conference (2020, November)

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See detailGPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine ULiege et al

in Nature Communications (2020), 11(1), 4752

Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH-secreting pituitary tumors over ... [more ▼]

Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH-secreting pituitary tumors over-expressing the orphan G-protein coupled receptor, GPR101. The role of GPR101 in GH secretion remains obscure. We studied GPR101 signaling pathways and their effects in HEK293 and rat pituitary GH3 cell lines, human tumors and in transgenic mice with elevated somatotrope Gpr101 expression driven by the rat Ghrhr promoter (GhrhrGpr101). Here, we report that Gpr101 causes elevated GH/prolactin secretion in transgenic GhrhrGpr101 mice but without hyperplasia/tumorigenesis. We show that GPR101 constitutively activates not only Gs, but also Gq/11 and G12/13, which leads to GH secretion but not proliferation. These signatures of GPR101 signaling, notably PKC activation, are also present in human pituitary tumors with high GPR101 expression. These results underline a role for GPR101 in the regulation of somatotrope axis function. [less ▲]

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See detailGPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Conference (2020)

Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH secreting pituitary tumors over ... [more ▼]

Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH secreting pituitary tumors over-expressing the orphan G-protein coupled receptor, GPR101. The role of GPR101 in GH secretion remains obscure. We studied GPR101 signaling pathways and their effects in HEK293 and rat pituitary GH3 cell lines, human tumors and in transgenic mice with elevated somatotrope Gpr101 expression driven by the rat Ghrhr promoter (GhrhrGpr101). We report that Gpr101 causes elevated GH/prolactin secretion in transgenic GhrhrGpr101 mice. We also show that GPR101 promotes GH secretion through the activation of not only Gs, but also Gq/11, in a PKA and PKC-dependent manner, respectively. Interestingly, in stark contrast with other Gs-coupled receptors, GPR101 activation did not lead to the proliferation of somatotrope cells. These signatures of GPR101 signaling, notably PKC activation, are also present in human X-LAG pituitary tumors with high GPR101 expression. These results underline a role for GPR101 in the regulation of somatotrope axis function. [less ▲]

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See detailGPR101 orphan receptor in XLAG syndrome
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Conference (2019, December)

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See detailPharmacology of GPR101 orphan receptor
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Conference (2019, July)

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See detailThe Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment
Reynders, Nathan; Abboud, Dayana ULiege; Baragli, Alexandra et al

in Cells (2019), 8(6),

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See detailGPR101 orphan receptor in XLAG syndrome
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Conference (2019, May)

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See detailSOMATOSTATIN ANALOGUE RESISTANCE IN X-LAG SYNDROME - IDENTIFICATION OF THE UNDERLYING MECHANISMS
Vandevoorde, Stéphanie ULiege; Abboud, Dayana ULiege; Laschet, Céline et al

Poster (2019, May)

INTRODUCTION | X-Linked Acro-Gigantism (X-LAG) Syndrome is a rare genetic disorder caused by a microduplication on the X-chromosome of an array of genes comprising gpr101. This disorder leads to a ... [more ▼]

INTRODUCTION | X-Linked Acro-Gigantism (X-LAG) Syndrome is a rare genetic disorder caused by a microduplication on the X-chromosome of an array of genes comprising gpr101. This disorder leads to a pituitary adenoma secreting high levels of growth hormone, via elevated cAMP levels inside the somatotrophs of the adenoma. However, X-LAG patients cannot be treated by somatostatin analogues (SSA), such as octreotide, and present only a minor decrease in cAMP in response to pasireotide. METHODS & RESULTS | In heterologously transfected GH3 cells, cAMP levels do not decrease in presence of GPR101 in response to SSA treatment because the coupling of Gαi-proteins to the somatostatin receptors expressed in the pituitary adenoma (i.e., SSTR2 and SSTR5) is decreased in presence of GPR101. Moreover, due to a decreased arrestin-coupling to SSTR2 in presence of GPR101, SSTR2 is less endocytosed after stimulation. CONCLUSION | GPR101 quenches the signalling pathways of SSTR2 and SSTR5. However, further studies are necessary to determine the underlying cause of the patients’ resistance to SSA [less ▲]

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See detailGPR101 orphan receptor in XLAG syndrome
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Conference (2018, December)

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See detailDiscovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia
Regenass, Pierre; Abboud, Dayana ULiege; Daubeuf, François et al

in Journal of Medicinal Chemistry (2018), 61

Detailed reference viewed: 24 (1 ULiège)
See detailGPR101 orphan receptor: a novel cause of growth hormone deregulation
Abboud, Dayana ULiege; Daly, Adrian ULiege; Laschet, Céline ULiege et al

Conference (2018, July 05)

Detailed reference viewed: 61 (7 ULiège)
See detailThe orphan receptor GPR101 as a novel cause of growth hormone deregulation
Abboud, Dayana ULiege; Daly, Adrian ULiege; Dupuis, Nadine et al

Poster (2018, July)

Detailed reference viewed: 24 (3 ULiège)