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See detailScaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).
Bousquet, J.; Farrell, J.; Crooks, G. et al

in Clinical and Translational Allergy (2016), 6

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic ... [more ▼]

Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network. It is deployed in collaboration with the World Health Organization Global Alliance against Chronic Respiratory Diseases (GARD). The European Innovation Partnership on Active and Healthy Ageing has proposed a 5-step framework for developing an individual scaling up strategy: (1) what to scale up: (1-a) databases of good practices, (1-b) assessment of viability of the scaling up of good practices, (1-c) classification of good practices for local replication and (2) how to scale up: (2-a) facilitating partnerships for scaling up, (2-b) implementation of key success factors and lessons learnt, including emerging technologies for individualised and predictive medicine. This strategy has already been applied to the chronic respiratory disease action plan of the European Innovation Partnership on Active and Healthy Ageing. [less ▲]

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See detailMACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation.
Bousquet, J.; Schunemann, H. J.; Fonseca, J. et al

in Allergy (2015), 70(11), 1372-92

Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification ... [more ▼]

Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) is a simple system centred around the patient which was devised to fill many of these gaps using Information and Communications Technology (ICT) tools and a clinical decision support system (CDSS) based on the most widely used guideline in allergic rhinitis and its asthma comorbidity (ARIA 2015 revision). It is one of the implementation systems of Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA). Three tools are used for the electronic monitoring of allergic diseases: a cell phone-based daily visual analogue scale (VAS) assessment of disease control, CARAT (Control of Allergic Rhinitis and Asthma Test) and e-Allergy screening (premedical system of early diagnosis of allergy and asthma based on online tools). These tools are combined with a clinical decision support system (CDSS) and are available in many languages. An e-CRF and an e-learning tool complete MASK. MASK is flexible and other tools can be added. It appears to be an advanced, global and integrated ICT answer for many unmet needs in allergic diseases which will improve policies and standards. [less ▲]

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See detailAccounting for heterogeneous variances in multi-trait evaluation of Jersey type traits
Gengler, Nicolas ULiege; Wiggans, G. R.; Thornton, L. et al

in Journal of Dairy Science (2005, July), 83/88(Suppl. 1/ Suppl. 1), 11

The multi-trait genetic evaluation system for type traits was modified to estimate adjustments for heterogeneous variance (HV) simultaneously with estimated breeding values (EBV) for final score and 14 ... [more ▼]

The multi-trait genetic evaluation system for type traits was modified to estimate adjustments for heterogeneous variance (HV) simultaneously with estimated breeding values (EBV) for final score and 14 linear traits. Heterogeneity, estimated for transformed traits, was regressed within parity toward the population variance means by fitting a model with fixed effects of mean final score forherd, size of contemporary group, appraisal month, and appraisal year-season and a random effect for interaction between herd and appraisal date. Method R was used to estimate variances for the heterogeneity model in each EBV iteration. Data was from the 766,725 appraisals included in the official November 2004 evaluation. Parent averages were calculated from evaluations with recent appraisals removed. Annual trends for cow EBV were lower with HV adjustment than for unadjusted EBV for all traits. The SD of Mendelian sampling (evaluation minus mean of parent evaluations) declined less over time for HV adjusted than for unadjusted evaluations. The slope at year 2000 of Mendeliansampling SD from HV adjusted evaluations was only 22% for udder depth to 48% for teat length of the slope of that for unadjusted evaluations. This adjustment for HV was implemented in May 2001 and should make selection decisions more accurate by using these proposed integrated HV adjustments. [less ▲]

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