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See detailProceedings of the 8th FARAH-Day
Bayrou, Calixte ULiege; Cesarini Latorre, Carlota ULiege; Delguste, Catherine ULiege et al

Book published by Presses de la Faculté de Médecine Vétérinaire de l'ULiège (2021)

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See detailPrévention de la myopathie atypique à l’automne
Votion, Dominique ULiege

Conference (2021, September 14)

La myopathie atypique est une intoxication sévère suite à l’ingestion de graines et de plantules de certaines espèces d’érable. Cette conférence décrit les mesures visant à réduire le risque à l’automne ... [more ▼]

La myopathie atypique est une intoxication sévère suite à l’ingestion de graines et de plantules de certaines espèces d’érable. Cette conférence décrit les mesures visant à réduire le risque à l’automne, saison où la majeure partie des cas sont recensés. [less ▲]

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See detailImpact des facteurs climatiques sur le nombre de cas annuel de myopathie atypique
Stern, David ULiege; Fettweis, Xavier ULiege; François, Anne-Christine ULiege et al

Poster (2021, May)

La myopathie atypique est une intoxication saisonnière résultant de l’ingestion des samares (à l’automne) ou de plantules (au printemps) de l’érable sycomore (Acer pseudoplatanus). Des conditions ... [more ▼]

La myopathie atypique est une intoxication saisonnière résultant de l’ingestion des samares (à l’automne) ou de plantules (au printemps) de l’érable sycomore (Acer pseudoplatanus). Des conditions météorologiques particulières ont été associées à l’émergence de séries cliniques de cette maladie. L’objectif de cette étude est d’identifier les facteurs climatiques contribuant à expliquer la variation du nombre de cas de myopathie atypique par année et par saison, en Belgique et en France Des cas sont survenus sur l’ensemble du territoire franco-belge mais l’incidence de la maladie est plus élevée dans les provinces de Liège, Namur et Luxembourg pour la Belgique et en Champagne-Ardenne et Picardie pour la France. Les gelées printanières tardives et un faible taux de précipitations estivales semblent impacter le risque de déclarations à l’automne suivant alors que les grands vents automnaux contribueraient à initier les grandes séries de cas. Aux facteurs climatiques viennent s’ajouter au risque d’intoxication d’autres paramètres, tels que la présence d’érables sycomores et leur densité, la gestion des pâtures, des équidés, ou encore l’éveil du secteur à la nécessité de déclarer la maladie et de documenter les cas. [less ▲]

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See detailL'érable sycomore: une espèce d'érables toxique
Genoux, Nelly; Votion, Dominique ULiege; Marcillaud-Pitel, Christel

E-print/Working paper (2021)

Très commun dans nos campagnes, l’érable sycomore est un arbre toxique pour les chevaux. L’ingestion des fruits et plantules de l’arbre est à l’origine d’une maladie grave affectant les muscles ... [more ▼]

Très commun dans nos campagnes, l’érable sycomore est un arbre toxique pour les chevaux. L’ingestion des fruits et plantules de l’arbre est à l’origine d’une maladie grave affectant les muscles respiratoires, posturaux et le myocarde, à l’issue souvent mortelle : la myopathie atypique. L’intoxication est saisonnière, avec deux principales périodes à risque au pâturage : la levée des plantules au printemps et la chute des fruits (samares) à l’automne. Comment limiter les risques sans systématiquement abattre les érables ? [less ▲]

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See detailComparison of Fecal Microbiota of Horses Suffering from Atypical Myopathy and Healthy Co-Grazers
Wimmer-Scherr, Christina ULiege; Taminiau, Bernard ULiege; Renaud, Benoît ULiege et al

in Animals MPDI (2021), 11(506),

Equine atypical myopathy (AM) is caused by hypoglycin A (HGA) and methylenecyclopropylglycine (MCPG) intoxication resulting from the ingestion of seeds or seedlings of some Acer tree species ... [more ▼]

Equine atypical myopathy (AM) is caused by hypoglycin A (HGA) and methylenecyclopropylglycine (MCPG) intoxication resulting from the ingestion of seeds or seedlings of some Acer tree species. Interestingly, not all horses pasturing in the same toxic environment develop signs of the disease. In other species, it has been shown that the intestinal microbiota has an impact on digestion, metabolism, immune stimulation and protection from disease. The objective of this study was to characterize and compare fecal microbiota of horses suffering from AM and healthy co-grazers. Furthermore, potential differences in fecal microbiota regarding the outcome of diseased animals were assessed. This prospective observational study included 59 horses with AM (29 survivors and 30 nonsurvivors) referred to three Belgian equine hospitals and 26 clinically healthy co-grazers simultaneously sharing contaminated pastures during spring and autumn outbreak periods. Fresh fecal samples (rectal or within 30min of defecation) were obtained from all horses and bacterial taxonomy profiling obtained by 16S amplicon sequencing was used to identify differentially distributed bacterial taxa between AM-affected horses and healthy co-grazers. Fecal microbial diversity and evenness were significantly (p < 0.001) higher in AM-affected horses as compared with their non-affected co-grazers. The relative abundance of families Ruminococcaceae, Christensenellaceae and Akkermansiaceae were higher (p ≤ 0.001) whereas those of the Lachnospiraceae (p = 0.0053), Bacteroidales (p < 0.0001) and Clostridiales (p = 0.0402) were lower in horses with AM, especially in those with a poor prognosis. While significant shifts were observed, it is still unclear whether they result from the disease or might be involved in the onset of disease pathogenesis. [less ▲]

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See detailFiche de synthèse n°01- toxicologie vétérinaire
Votion, Dominique ULiege; François, Anne-Christine ULiege; Renaud, Benoît ULiege et al

Learning material (2021)

Cette fiche résume les éléments essentiels relatifs à l'intoxication à l'érable sycomore (Acer pseudoplatanus)

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See detailFiche de synthèse n°XX- toxicologie vétérinaire
Votion, Dominique ULiege; François, Anne-Christine ULiege; Gustin, Pascal ULiege

Learning material (2021)

Modèle de fiche de synthèse d'un sujet de toxicologie vétérinaire à rédiger par les étudiants en médecine vétérinaire (UE VETE 2066) dans le cadre des travaux dirigés.

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See detailAcylcarnitine profile in Alaskan sled dogs during submaximal multiday exercise points out metabolic flexibility and liver role in energy metabolism.
Tosi, Irène ULiege; Art, Tatiana ULiege; BOEMER, François ULiege et al

in PLoS ONE (2021), 16(8), 0256009

Alaskan sled dogs develop a particular metabolic strategy during multiday submaximal exercise, allowing them to switch from intra-muscular to extra-muscular energy substrates thus postponing fatigue ... [more ▼]

Alaskan sled dogs develop a particular metabolic strategy during multiday submaximal exercise, allowing them to switch from intra-muscular to extra-muscular energy substrates thus postponing fatigue. Specifically, a progressively increasing stimulus for hepatic glycogenolysis and gluconeogenesis provides glucose for both fueling exercise and replenishing the depleted muscle glycogen. Moreover, recent studies have shown that with continuation of exercise sled dogs increase their insulin-sensitivity and their capacity to transport and oxidize glucose and carbohydrates rather than oxidizing fatty acids. Carnitine and acylcarnitines (AC) play an essential role as metabolic regulators in both fat and glucose metabolism; they serve as biomarkers in different species in both physiologic and pathologic conditions. We assessed the effect of multiday exercise in conditioned sled dogs on plasma short (SC), medium (MC) and long (LC) chain AC by tandem mass spectrometry (MS/MS). Our results show chain-specific modification of AC profiles during the exercise challenge: LCACs maintained a steady increase throughout exercise, some SCACs increased during the last phase of exercise and acetylcarnitine (C2) initially increased before decreasing during the later phase of exercise. We speculated that SCACs kinetics could reflect an increased protein catabolism and C2 pattern could reflect its hepatic uptake for energy-generating purposes to sustain gluconeogenesis. LCACs may be exported by muscle to avoid their accumulation to preserve glucose oxidation and insulin-sensitivity or they could be distributed by liver as energy substrates. These findings, although representing a "snapshot" of blood as a crossing point between different organs, shed further light on sled dogs metabolism that is liver-centric and more carbohydrate-dependent than fat-dependent and during prolonged submaximal exercise. [less ▲]

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See detailAtypical myopathy in 2 Bactrian camels
Hirz, M; Gregersen, H.A.; Sander, J. et al

in Journal of Veterinary Diagnostic Investigation (2021), 33(5), 961-965

Atypical myopathy (AM) is an acute seasonal rhabdomyolysis seen primarily in equids, caused by the ingestion of sycamore maple samaras containing hypoglycin A (HGA) and methylenecyclopropyl-glycine (MCPG ... [more ▼]

Atypical myopathy (AM) is an acute seasonal rhabdomyolysis seen primarily in equids, caused by the ingestion of sycamore maple samaras containing hypoglycin A (HGA) and methylenecyclopropyl-glycine (MCPG). Toxic metabolites inhibit acyl-CoA dehydrogenases and enoyl-CoA hydratases, causing selective hyaline degeneration of type I muscle fibers. Two zoo-kept Bactrian camels (Camelus bactrianus) with a fatal course of AM had sudden onset of muscle pain and weakness, recumbency, and dysphagia, accompanied by increased serum creatine kinase activity and detection in serum of HGA, MCPG, and metabolites. The ingestion of sycamore maple material can cause AM in Bactrian camels, and trees of the Sapindaceae family should be avoided in enclosures. [less ▲]

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See detailIn Vitro Assays for the Assessment of Impaired Mitochondrial Bioenergetics in Equine Atypical Myopathy.
Kruse, Caroline ULiege; Stern, David ULiege; Mouithys-Mickalad, Ange ULiege et al

in Life (Basel, Switzerland) (2021), 11(7),

Equine atypical myopathy is a seasonal intoxication of grazing equids. In Europe, this poisoning is associated with the ingestion of toxins contained in the seeds and seedlings of the sycamore maple (Acer ... [more ▼]

Equine atypical myopathy is a seasonal intoxication of grazing equids. In Europe, this poisoning is associated with the ingestion of toxins contained in the seeds and seedlings of the sycamore maple (Acer pseudoplatanus). The toxins involved in atypical myopathy are known to inhibit ß-oxidation of fatty acids and induce a general decrease in mitochondrial respiration, as determined by high-resolution respirometry applied to muscle samples taken from cases of atypical myopathy. The severe impairment of mitochondrial bioenergetics induced by the toxins may explain the high rate of mortality observed: about 74% of horses with atypical myopathy die, most within the first two days of signs of poisoning. The mechanism of toxicity is not completely elucidated yet. To improve our understanding of the pathological process and to assess therapeutic candidates, we designed in vitro assays using equine skeletal myoblasts cultured from muscle biopsies and subjected to toxins involved in atypical myopathy. We established that equine primary myoblasts do respond to one of the toxins incriminated in the disease. [less ▲]

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See detailGrazing Mares on Pasture with Sycamore Maples: A Potential Threat to Suckling Foals and Food Safety through Milk Contamination.
Renaud, Benoît ULiege; François, Anne-Christine ULiege; Boemer, François ULiege et al

in Animals : an open access journal from MDPI (2021), 11(1),

Equine atypical myopathy (AM) is seasonal intoxication resulting from the ingestion of seeds and seedlings of the sycamore maple (Acer pseudoplatanus) that contain toxins, among them, hypoglycin A (HGA ... [more ▼]

Equine atypical myopathy (AM) is seasonal intoxication resulting from the ingestion of seeds and seedlings of the sycamore maple (Acer pseudoplatanus) that contain toxins, among them, hypoglycin A (HGA). Literature mentions several cases of AM among gravid mares and in unweaned foals. The objective of this study was to determine whether HGA and/or its metabolite are present in milk from grazing mares exposed to sycamore maple trees as confirmed by detection of HGA and its metabolite in their blood. Four mare/foal couples were included in the study. Both HGA and its metabolite were detectable in all but one of the milk samples. To our knowledge, this is the first study describing transfer of HGA to the milk. This unprecedented observation could partially explain cases of unweaned foals suffering from AM. However, a transplacental transfer of the toxin cannot be excluded for newborn foals. Besides being a source of contamination for offspring, milk contamination by toxins from fruits of trees of the Sapindaceae family might constitute a potential risk for food safety regarding other species' raw milk or dairy products. [less ▲]

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See detailMetabolomic Signatures Discriminate Horses with Clinical Signs of Atypical Myopathy from Healthy Co-grazing Horses
Wouters, Clovis ULiege; Toquet, Marie-Pierre; Renaud, Benoît ULiege et al

in Journal of Proteome Research (2021)

The objective of this study was to compare the blood metabolomic profiles of horses with AM clinical signs with those of healthy co-grazing (Co-G) horses.

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See detailEquine atypical myopathy: Prevention is still the key
François, Anne-Christine ULiege; Renaud, Benoît ULiege; Kruse, Caroline ULiege et al

Poster (2020, November 20)

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See detailGeolocation and temporal distribution of equine atypical myopathy cases in Belgium and France from years 2006 to 2019
Stern, David ULiege; Fettweis, Xavier ULiege; Renaud, Benoît ULiege et al

Poster (2020, November 20)

Atypical myopathy (AM) is a severe and often fatal muscle disorder arising from ingestion of toxins contained in sycamore maple (Acer pseudoplatanus) seeds and seedlings. Progresses in research to ... [more ▼]

Atypical myopathy (AM) is a severe and often fatal muscle disorder arising from ingestion of toxins contained in sycamore maple (Acer pseudoplatanus) seeds and seedlings. Progresses in research to diagnose and treat AM after intoxication are moving forward, but the acuteness of the disease with a fatality rate of ~75% reinforces the need for preventive measures. The condition is a seasonal disorder. Ingestions of Samaras (seeds) in autumn and seedlings the following spring causes two subsequent clinical case series, with a majority of cases observed in autumn. [less ▲]

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See detailEquipedia: La myopathie atypique
Votion, Dominique ULiege

E-print/Working paper (2020)

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See detailMyopathie atypique et toxicité des samares: réponse de l'expert au courrier des lecteurs
Votion, Dominique ULiege

in Cheval Santé (2020), 126

Réponse via le courrier des lecteurs à diverses questions relatives à la toxicité des érables

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See detailRéponses aux Questions Fréquemment Posées (FAQs) à Propos de l’Alimentation et de la Gestion des Équidés ainsi que de la gestion des Pâtures afin de Réduire le Risque de Myopathie Atypique
François, Anne-Christine ULiege; Votion, Dominique ULiege

in Animals (2020), 10

Cet document est la traduction en français de l'article: Votion D-M., François A-C., Kruse C., Renaud R., Farinelle A., Bouquieaux M-C., Marcillaud-Pitel C., Gustin P. Answers to the frequently asked ... [more ▼]

Cet document est la traduction en français de l'article: Votion D-M., François A-C., Kruse C., Renaud R., Farinelle A., Bouquieaux M-C., Marcillaud-Pitel C., Gustin P. Answers to the frequently asked questions regarding horse feeding and management practices to reduce the risk of atypical myopathy. Il comporte de nombreuses illustrations [less ▲]

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See detailCarnet de santé: la myopathie atypique
Votion, Dominique ULiege

in Cheval Santé (2020), (130), 48-50

La myopathie atypique est une maladie saisonnière désormais bien présente en France et en Europe. Elle se caractérise par une destruction des muscles posturaux, respiratoires et du myocarde. Des études ... [more ▼]

La myopathie atypique est une maladie saisonnière désormais bien présente en France et en Europe. Elle se caractérise par une destruction des muscles posturaux, respiratoires et du myocarde. Des études récentes ont montré que la cause est une toxine présente dans les graines de certains arbres du genre « Acer » (érable), dont l’« Acer pseudoplatanus » ou érable sycomore. [less ▲]

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See detailProceedings of the 7th FARAH-Day
Bayrou, Calixte ULiege; Cesarini Latorre, Carlota ULiege; Delguste, Catherine ULiege et al

Book published by Presses de la Faculté de Médecine vétérinaire de l'Université de Liège (2020)

Detailed reference viewed: 48 (12 ULiège)