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See detailEstimating myostatin gene effect on milk performance traits using estimated gene content for a large number of non-genotyped cows
Buske, Bernd; Vanrobays, Marie-Laure ULiege; Szydlowski, Maciej et al

Conference (2011, August 29)

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See detailEstimating myostatin gene effect on milk performance traits using estimated gene content for a large number of non-genotyped cows
Buske, Bernd ULiege; Szydlowski, Maciej; Verkenne, Catherine et al

in Animal (2011), 5(1), 43-47

The objective of this study was to estimate the myostatin (mh) gene’s effect on milk, protein and fat yield in a large heterogeneous cow population, of which only a small portion was genotyped. For this ... [more ▼]

The objective of this study was to estimate the myostatin (mh) gene’s effect on milk, protein and fat yield in a large heterogeneous cow population, of which only a small portion was genotyped. For this purpose, a total of 13 992 889 test-day records derived from 799 778 cows were available. The mh gene effect was estimated via BLUP using a multi-lactation, multi-trait random regression test-day model with an additional fixed regression on mh gene content. As only 1416 animals, (of which 1183 cows had test-day records) were genotyped, more animals of additional breeds with assumed known genotype were added to estimate the genotype (gene content) of the remaining cows more reliably. This was carried out using the conventional pedigree information between genotyped animals and their non-genotyped relatives. Applying this rule, mean estimated gene content over all cows with test-day records was 0.104, showing that most cows were homozygous 1/1. In contrast, when gene content estimation was only based on genotyped animals, mean estimated gene content over all cows with test-day records was with 1.349 overestimated. Therefore, the applied method for gene content estimation in large populations needs additional genotype assumptions about additional animals representing genetic diversity when the breed composition in the complete population is heterogeneous and only a few animals from predominantly one breed are genotyped. Concerning allele substitution effects for one copy of the ‘mh’ gene variant, significant decreases of 276.1 kg milk, 23.6 kg fat and 22.8 kg protein/lactation were obtained on average when gene content estimation was additionally based on animals with assumed known genotype. Based on this result, knowledge of the mh genotypes and their effects has the potential to improve milk performance traits in cattle. [less ▲]

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See detailBayesian approach to integrate molecular data into genetic evaluations
Gengler, Nicolas ULiege; Verkenne, Catherine

in Interbull Bulletin (2007), 37

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