References of "VRANKEN, Laura"
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See detailEvaluation of Metformin impact on vitamin B12 status
VRANKEN, Laura ULiege; FONTAINE, Corentin ULiege; LUKAS, Pierre ULiege et al

Poster (2019, May)

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See detailComparison of cardiac biomarker dynamics in marathon, semimarathon and untrained runners: what is the impact on results interpretation?
Le Goff, Caroline ULiege; Lennartz, Lieselotte; VRANKEN, Laura ULiege et al

in Journal of Laboratory and Precision Medicine (2019), 4(6), 10

Background: Cardiac biomarkers elevations have been described after running exercise. Objective of our study was to check cardiac biomarker dynamics in well trained athletes and untrained middle aged ... [more ▼]

Background: Cardiac biomarkers elevations have been described after running exercise. Objective of our study was to check cardiac biomarker dynamics in well trained athletes and untrained middle aged apparently healthy men and to highlight the impact on the lab results interpretation in emergency department. Methods: Cardiac biomarkers for ischemic condition, cardiac stretch and fibrotic processes were tested in different type of runners before, directly after and 3 hours after running. Markers for inflammation, muscle disease and renal function were also measured. Results: Cardiac biomarker levels between groups were not statistically different in the pre-exercise samples for natriuretic peptides [B-type natriuretic peptide (BNP), N-terminal Pro BNP (NT-ProBNP)] and galectin-3 (Gal-3), only Troponin I levels were higher. Directly after exercise, all cardiac biomarker levels were higher compared to the baseline, Gal-3 and BNP levels decreased 3 hours after completion of the run.Troponin values continued to increase with highest levels 3 hours after exercise. Troponin T, NT-Pro BNP and Gal-3 also showed significant correlation to markers of inflammation, fibrosis and renal function. Conclusions: Exercises of different intensity can be associated with biochemical abnormalities and longterm consequences are unknown. In chest pain patients presenting to the emergency department possible impact of exercise on test results, especially Troponin, should be checked. [less ▲]

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See detailImpact of the creatinine-based equations used on the chronic kidney disease classification in a large laboratory database
masson, grégoire; VRANKEN, Laura ULiege; KRZESINSKI, Jean-Marie ULiege et al

in Nephrology Dialysis Transplantation (2019)

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See detailValidation of 24 blood gas analyzers, GEM 5000 Premier
GADISSEUR, Romy ULiege; MUSSO, Giuseppe ULiege; Cavalier, Etienne ULiege et al

Poster (2018, September 28)

Introduction: Point-of-care blood gas test results may help to take therapeutic decision by their immediate impact on patient care. Recently, a novel cartridge-type blood gas analyzer, the GEM Premier ... [more ▼]

Introduction: Point-of-care blood gas test results may help to take therapeutic decision by their immediate impact on patient care. Recently, a novel cartridge-type blood gas analyzer, the GEM Premier 5000 (IL-Werfen) was commercialized and 24 analyzers were installed at the University Hospital of Liège. One of them was installed in the main central laboratory, the 23 other ones were installed into 19 patient care units. Before the implementation, we evaluated the analytical performance of all the 24 GEM Premier 5000, for the determination of whole blood pH, pCO2 and pO2, electrolytes (Na+, K+, Cl−), ionized calcium (iCa2+), glucose, lactate and co-oximetry parameters ((total hemoglobin (tHb), oxyhemoglobin (O2Hb), carboxyhemoglobin (COHb), methemoglobin (metHb), deoxyhemoglobin (HHb)). Method: First, we evaluated the performance of the GEM Premier 5000 dedicated to the central lab, so-called “referent analyzer”, with 3 levels of External Quality Controls material (EQC RNA Medicals). CLSI EP5 recommends 2 replicates per run, 1 or 2 runs per day, for a minimum of 20 days. Nevertheless, we analyzed the 3 levels of EQC, 2 replicates per run, 2 runs per day during 5 consecutive days. Afterwards, on the whole 24 GEM Premier 5000, we analyzed aqueous QC material (Werfen GEM System Evaluator, level 1-2), 3 replicates within a single run, once per day, during 5 consecutive days. We determined the manufacturer's claim for Within-Run and Total precisions for each. Co-oxymetry parameters were not evaluated on 4 analyzers. Then, we compared the all 23 analyzers to the “referent analyzer” of the central lab. Therefore, for each parameter, we showed in a Youden diagram all the results obtained by 23 analyzers. The position of the acceptance ranges were shown graphically using the specifications for Acceptable(%) Root Mean Standard Deviation (RMSD) proposed by the German Guidelines for Quality (RILIBAK) for whole blood parameter, for different ranges of parameters. Results: The results showed a good correlation between analyzers excepted for some parameters. Lactate and MetHb: level 2 were often over-estimated when compared to “Reference Analyzer”. It could be explained by the fact that this IQC level contains very low Lactate and MetHb rates. The pO2 level2: some results were over estimated (random errors >< cassette reagents >< low values). The pO2 level1: over-estimated with 8 analyzers letting us think that the cassette reagent of our “Reference Analyzer” had a bias in the lower range. Conclusion: Performance evaluation of a large cluster of Blood Gas Analyzers is always a challenge for a Hospital. Accreditation is one of the main goal in each Belgian laboratory. Hospital Accreditation is also discussed in Belgium. This study shows an interesting approach to validate Blood Gas Analyzers for highlighting data. Based on our study results, we estimated that the evaluated instrument are a suitable blood gas analyzer for both POCT and laboratory use. [less ▲]

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See detailCARDIAC BIOMARKERS FLUCTUATION IN RUNNERS OF MARATHONS, SEMI-MARATHONS AND UNTRAINED RUNNERS
Le Goff, Caroline ULiege; VRANKEN, Laura ULiege; Kaux, Jean-François ULiege et al

in 23rd Annual Congress of the ECSS (2018, July)

INTRODUCTION: Regular exercise like running is one important part of the prevention program of cardiovascular disease. There are several studies on biomarker changes during marathons especially cardiac ... [more ▼]

INTRODUCTION: Regular exercise like running is one important part of the prevention program of cardiovascular disease. There are several studies on biomarker changes during marathons especially cardiac biomarkers have been studied and mild to moderate elevations have been described as a results of a running exercise Exact underlying mechanism for these biomarker elevations reflecting physiological or even pathobiological changes is unknown and less trained athletes might exhibit a higher risk compared to well trained. The aim of our study was to compare three cardiac biomarkers for ischemic condition , cardiac stretch and fibrotic processes were tested in different type of runners, trained marathon and semi-marathon runners and untrained runners before, directly after and 3 hours after the running exercise. METHODS: 23 marathon runners, 15 semi-marathon runners <44.1±8.4yo> and 17 healthy sedentary subjects < 37± 4.4 yo> were enrolled in our study. Blood samples were taken just before , just after and 3 hours after the race, centrifuged, aliquoted and stored frozen at -80°C before further analysis. The study was approved by the Ethical Committee of our University Hospital. The analyses were performed on the Abbott ARCHITECT i2000SR for the hs cTnI, BNP and Gal-3 and on the C8000 for hs-cTnT and NTproBNP according to the manufacturer’s instructions for use. RESULTS: In all 3 running groups there is an increase of cardiac biomarkers Troponin I, BNP, Galectin-3 and NT-ProBNP after completion of the physical exercise. Biomarkers increase is depending on the intensity and duration of the exercise and is higher in long distance marathon and semi-marathon runners compared to the control group with a 1 hour run. Cardiac biomarker levels between trained marathon and semi-marathon runners were not statistically different in the pre-exercise baseline samples for BNP, NT-Pro-BNP and Galectin-3. Compared to untrained runners only Troponin I levels were higher in baseline sample of marathon runners when compared to controls, cardiac Troponin T was less significant. CONCLUSION: In conclusion, the question whether running exercise of different intensity could be harmful to the heart has no simple answer. We could show that running exercise can be associated with biochemical abnormalities that may reflect adverse consequences on the heart like possible micro necrosis, oxidative stress, fibrosis and myocardial stretch. With exception of Troponin where levels continue to raise after end of running, NPs and Gal-3 levels normalized relatively fast after the exercise. The possible harmful effect of longer term cardiac consequences of repeated intensive sport acitvities still needs to be demonstrated. [less ▲]

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See detail24,25-dihydroxyvitamin D: a new biomarker in non-parathyroid hypercalcemia diagnosis
VRANKEN, Laura ULiege; FONTAINE, Corentin ULiege; SOUBERBIELLE, Jean-Claude et al

in Clinical Laboratory International (2018), 42(April/May), 23-25

The 24,25-dihydroxyvitamin D [24,25(OH)2D] is a catabolite of 25-hydroxyvitamin D [25(OH)D]. This transformation is performed by 1,25-hydroxyvitamin D 24-hydroxylase (or 24-hydroxylase, encoded by the ... [more ▼]

The 24,25-dihydroxyvitamin D [24,25(OH)2D] is a catabolite of 25-hydroxyvitamin D [25(OH)D]. This transformation is performed by 1,25-hydroxyvitamin D 24-hydroxylase (or 24-hydroxylase, encoded by the CYP24A1 gene). Mutations in CYP24A1 can lead to severe diseases such as idiopathic infantile hypercalcemia (IIH). Explorations of hypercalcemia with suppressed parathyroid hormone levels and normal or high phosphatemia should now include 24,25(OH)2D determination to exclude CYP24A1 mutations. 24,25(OH)2D and the vitamin D metabolite ratio (VMR) [i.e. 25(OH)D/24,25(OH)2D] are now considered as new biomarkers for the assessment of functional vitamin D deficiency. [less ▲]

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See detailPrévalence de l’hypovitaminose D chez la femme enceinte : quelle est la situation en région liégeoise ?
VRANKEN, Laura ULiege; EMONTS, Patrick ULiege; Bruyère, Olivier ULiege et al

in Revue Médicale de Liège (2018), 73(1), 10-16

Summary : Vitamin D deficiency is a worldwide health problem, also during pregnancy. Inadequate maternal vitamin D status in pregnancy is associated with poor fetal growth, impaired bone development and ... [more ▼]

Summary : Vitamin D deficiency is a worldwide health problem, also during pregnancy. Inadequate maternal vitamin D status in pregnancy is associated with poor fetal growth, impaired bone development and rickets in infants after birth. Furthermore, higher rates of preeclampsia and gestational diabetes are associated with low maternal vitamin D status during pregnancy. Toxicity of vitamin D is rare. Most countries recommend vitamin D supplementation during pregnancy but guidelines are controversial and inadequate compared to real mother’s and child’s needs. Wath’s the best strategy to follow and supplement mother during pregnancy? In a study carried out at the maternity clinic Notre- Dame des Bruyères (CHU Liège), we studied for a year the vitamin D concentrations of young women at start of pregnancy and of others after delivery to evaluate the local situation and management of vitamin D status during pregnancy. We did not collect the cord blood samples in this study. However, this is a project we would like to achieve soon. This would allow us to compare the vitamin D results of the mother at the time of delivery, to those of the cord blood of their respective child. [less ▲]

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See detailVitamine D et Vitamin D Binding protein
VRANKEN, Laura ULiege

Conference (2017, September 28)

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See detailComparison of cardiac biomarkers fluctuation in runners of marathons, semi-marathons and untrained runners
Le Goff, Caroline ULiege; VRANKEN, Laura ULiege; Kaux, Jean-François ULiege et al

in European Journal of Sports Medicine (2017, September), 5(Supplement 1), 16

BACKGROUND: Regular exercise like running is one important part of the prevention program of cardiovascular disease. There are several studies on biomarker changes during marathons especially cardiac ... [more ▼]

BACKGROUND: Regular exercise like running is one important part of the prevention program of cardiovascular disease. There are several studies on biomarker changes during marathons especially cardiac biomarkers have been studied and mild to moderate elevations have been described as a results of a running exercise Exact underlying mechanism for these biomarker elevations reflecting physiological or even pathobiological changes is unknown and less trained athletes might exhibit a higher risk compared to well trained The aim of our study was to compare three cardiac biomarkers for ischemic condition (Troponin), cardiac stretch (natriuretic peptides) and fibrotic processes (Galectin3) were tested in different type of runners, trained marathon and semimarathon runners and untrained runners before, directly after and 3 hours after the running exercise. METHODS: 23 (mean age 41± 8.8 yo) marathon runners, 15 semimarathon runners(44.1±8.4yo) and 17 healthy sedentary subjects (37± 4.4 yo) (race of 10 km, <2h of sport/week). Blood samples were taken just before (T0), just after (T1) and 3 hours (T3) after the race, centrifuged, aliquoted and stored frozen at 80C before further analysis. The study was approved by the Ethical Committee of our University Hospital. The analyses were performed on the Abbott ARCHITECT i2000SR (Abbott Laboratories, Germany) for the hs cTnI, BNP and Gal3 and on the C8000 (Roche Diagnostics, Switzerland) for hscTnT and NTproBNP according to the manufacturer’s instructions for use. RESULTS: In all 3 running groups there is an increase of cardiac biomarkers Troponin I, BNP, Galectin3 and NTProBNP after completion of the physical exercise. Biomarkers increase is depending on the intensity and duration of the exercise and is higher in long distance marathon and semimarathon runners compared to the control group with a 1 hour run. Cardiac biomarker levels between trained marathon and semimarathon runners were not statistically different in the preexercise baseline samples for BNP, NTProBNP and Galectin3. Compared to untrained runners only Troponin I levels were higher in baseline sample of marathon runners (hscTnI, p<0.03) when compared to controls, cardiac Troponin T (hscTnT, p<0.29) was less significant. CONCLUSIONS: Our study demonstrates that exercises of different intensity can be associated with biochemical abnormalities that may reflect adverse consequences on cardiac structure as fibrosis and biology. With exeption of Troponin I there was no difference in the preexercise baselines samples. [less ▲]

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See detailComparison of cardiac biomarker fluctuation in runners of marathons, semi-marathons and untrained runners
LE GOFF, Caroline ULiege; VRANKEN, Laura ULiege; van Nueten, Jan et al

in Clinical Chemistry and Laboratory Medicine (2017, June)

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See detailEtude rétrospective du bilan thyroïdien: définition de valeurs de référence pédiatriques
LADANG, Aurélie ULiege; VRANKEN, Laura ULiege; LUYCKX, Françoise ULiege et al

in Revue Médicale de Liège (2017)

Defining reference range is an essential tool for diagnostic. Age and sexe influences on thyroid hormone levels have been already discussed. In this study, we are defining a new pediatric reference range ... [more ▼]

Defining reference range is an essential tool for diagnostic. Age and sexe influences on thyroid hormone levels have been already discussed. In this study, we are defining a new pediatric reference range for TSH, FT3 and FT4 for Cobas C6000 analyzer. To do so, we have taken in account 0 to 18 year old outclinic patients. During the first year of life, thyroid hormone levels change dramatically before getting stabilized around 3 years old. We also compared our results to those obtained in a Canadian large-scale prospective study (the CALIPER initiative). [less ▲]

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