References of "VRANKEN, Laura"
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See detailCarence en vitamine B12 : diagnostic et prise en charge
DELANNOY, Pauline ULiege; VRANKEN, Laura ULiege; CAVALIER, Etienne ULiege et al

in Tempo Médical (2020)

Les seuls êtres vivants capables de synthétiser la vitamine B12 (ou cobalamine) sont des bactéries filogénétiquement très anciennes, appelées archéobactéries. La cobalamine est pourtant essentielle pour ... [more ▼]

Les seuls êtres vivants capables de synthétiser la vitamine B12 (ou cobalamine) sont des bactéries filogénétiquement très anciennes, appelées archéobactéries. La cobalamine est pourtant essentielle pour l’homme. En effet, elle intervient en tant que coenzyme dans deux voies clés du métabolisme cellulaire aboutissant à la synthèse de l’ADN et de la méthionine, à partir de l’homocystéine. Une carence B12 est souvent observée chez les végétariens, les personnes âgées, les patients avec un bypass gastrique, avec une gastrite chronique auto-immune, les patients atteints de maladies inflammatoires intestinales ou traités par metformine, par exemple. Pour ces groupes à risque, il peut donc être justifié, surtout après des manifestations biologiques et cliniques, de prendre des compléments contenant de la vitamine B12, tout en veillant à des apports suffisants en acide folique. [less ▲]

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See detailA novel method for creatinine adjustment makes the revised Lund-Malmö GFR estimating equation applicable in children
Bjork, Jonas; Nyman, Ulf; DELANAYE, Pierre ULiege et al

in Scandinavian Journal of Clinical and Laboratory Investigation (2020), 80(6), 456-463

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See detailSimultaneous measurement of 25(OH)-vitamin D and 24,25(OH)2-vitamin D to define cut-offs for CYP24A1 mutation and vitamin D deficiency in a population of 1200 young subjects.
Cavalier, Etienne ULiege; Huyghebaert, Loreen ULiege; ROUSSELLE, Olivier ULiege et al

in Clinical chemistry and laboratory medicine (2020), 58(2), 197-201

Background Simultaneous measurement of 25(OH)D and 24,25(OH)2D is a new tool for predicting vitamin D deficiency and allows evaluating CYP24A1 lack of function. Interpretation of 24,25(OH)2D should be ... [more ▼]

Background Simultaneous measurement of 25(OH)D and 24,25(OH)2D is a new tool for predicting vitamin D deficiency and allows evaluating CYP24A1 lack of function. Interpretation of 24,25(OH)2D should be performed according to 25(OH)D levels and a ratio, called the vitamin D metabolite ratio (VMR) has been proposed for such a purpose. Unfortunately, the VMR can be expressed in different ways and cannot be used if 24,25(OH)2D concentrations are undetectable. Here, we propose evaluating the enzyme activity taking into consideration the probability that a normal population presents undetectable 24,25(OH)2D concentrations according to 25(OH)D levels. We thus retrospectively measured 25(OH)D and 24,25(OH)2D in a population of 1200 young subjects to evaluate the 25(OH)D threshold above which the enzyme was induced. Methods Serum samples from 1200 infants, children, adolescent and young adults were used to simultaneously quantify 25(OH)D and 24,25(OH)2D by LCMS/MS. Results Median (interquartile range [IQR]) levels were 20.6 (14.4-27.2) ng/mL for 25(OH)D. 172 subjects (14.3%) presented 24,25(OH)2D values below the LOQ. When 25(OH)D values were <11 ng/mL, 63.1% of subjects presented undetectable 24,25(OH)2D concentrations. Percentage decreased with increasing 25(OH)D values to become 19.7% for 25(OH)D comprised between 12 and 15 ng/mL, 5.1% for 25(OH)D between 16 and 20 and 0.7% for 25(OH)D >21 ng/mL. Conclusions We suggest using a statistical approach to evaluate CYP24A1 function according to 25(OH)D concentrations. Our results also show that vitamin D deficiency, as defined biochemically, could be around 20 ng/mL in infants, children, adolescent and young adults and that vitamin D deficiency could be evaluated on a more individual basis. [less ▲]

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See detailImpact of Metformin on vitamin B12 status
VRANKEN, Laura ULiege; FONTAINE, Corentin ULiege; VALDES SOCIN, Hernan Gonzalo ULiege et al

Poster (2019, November 15)

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See detailBiomarkers of neonatal stress assessment: A prospective study.
ROUATBI, Hatem ULiege; Zigabe, Serge; Gkiougki, Eva et al

in Early Human Development (2019), 137

INTRODUCTION: Early diagnosis of perinatal asphyxia, the major cause of neonatal mortality and morbidity, might be improved by the detection of neonatal stress biomarkers such as cardiac troponin (CTn)T ... [more ▼]

INTRODUCTION: Early diagnosis of perinatal asphyxia, the major cause of neonatal mortality and morbidity, might be improved by the detection of neonatal stress biomarkers such as cardiac troponin (CTn)T, CTnI, NT-Terminal-pro-Brain Natriuretic Peptide (NT-pro-BNP), copeptin, and high sensitivity C-reactive protein (hs-CRP). However, reference values in neonates are lacking. The objective of our study was therefore to establish a reference range of these biomarkers in healthy full term newborns and to analyze the influence of delivery mode on their cord blood concentrations. PATIENTS AND METHODS: CTnT, CTnI, NT-pro-BNP, Copeptin and hs-CRP levels were determined in 201 neonates enrolled in this prospective study and correlated to the delivery mode and post-natal outcome. RESULTS: Using the 99th percentile, the upper reference limit in healthy newborns was established for all biomarkers. Neonates born after complicated delivery had significantly higher values of CTnT, CTnI and Copeptin than those born after uncomplicated delivery. In the multiple regression models with CTnT as dependent variable, the delivery mode was the statistically significant independent variable. CONCLUSION: In this study, we established reference values of cord blood concentrations of cardiac stress biomarkers in healthy newborns. We showed that cardiac-related birth stress is dependent on delivery mode. [less ▲]

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See detailEvaluation of Metformin impact on vitamin B12 status
VRANKEN, Laura ULiege; FONTAINE, Corentin ULiege; LUKAS, Pierre ULiege et al

Poster (2019, May)

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See detailCardiac stress biomarkers in neonates: role of the delivery mode
ROUATBI, Hatem ULiege; Gkiouki, E.; Zigabe, Serge et al

Poster (2019, May)

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See detailComparison of cardiac biomarker dynamics in marathon, semimarathon and untrained runners: what is the impact on results interpretation?
Le Goff, Caroline ULiege; Lennartz, Lieselotte; VRANKEN, Laura ULiege et al

in Journal of Laboratory and Precision Medicine (2019), 4(6), 10

Background: Cardiac biomarkers elevations have been described after running exercise. Objective of our study was to check cardiac biomarker dynamics in well trained athletes and untrained middle aged ... [more ▼]

Background: Cardiac biomarkers elevations have been described after running exercise. Objective of our study was to check cardiac biomarker dynamics in well trained athletes and untrained middle aged apparently healthy men and to highlight the impact on the lab results interpretation in emergency department. Methods: Cardiac biomarkers for ischemic condition, cardiac stretch and fibrotic processes were tested in different type of runners before, directly after and 3 hours after running. Markers for inflammation, muscle disease and renal function were also measured. Results: Cardiac biomarker levels between groups were not statistically different in the pre-exercise samples for natriuretic peptides [B-type natriuretic peptide (BNP), N-terminal Pro BNP (NT-ProBNP)] and galectin-3 (Gal-3), only Troponin I levels were higher. Directly after exercise, all cardiac biomarker levels were higher compared to the baseline, Gal-3 and BNP levels decreased 3 hours after completion of the run.Troponin values continued to increase with highest levels 3 hours after exercise. Troponin T, NT-Pro BNP and Gal-3 also showed significant correlation to markers of inflammation, fibrosis and renal function. Conclusions: Exercises of different intensity can be associated with biochemical abnormalities and longterm consequences are unknown. In chest pain patients presenting to the emergency department possible impact of exercise on test results, especially Troponin, should be checked. [less ▲]

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See detailImpact of the creatinine-based equations used on the chronic kidney disease classification in a large laboratory database
masson, grégoire; VRANKEN, Laura ULiege; KRZESINSKI, Jean-Marie ULiege et al

in Nephrology Dialysis Transplantation (2019)

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