References of "Schmidt, Christina"
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See detailArousals during sleep are associated with brain tau and amyloid-β burden in healthy older adults
Chylinski, Daphné ULiege; Rudzik, Franziska; Coppieters't Wallant, Dorothe ULiege et al

Conference (2018, September)

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See detailHuman brain patterns underlying vigilant attention: impact of sleep debt, circadian phase and attentional engagement
Maire, Micheline; Reichert, Carolin Franziska; Gabel, Virginie et al

in Scientific Reports (2018), 8(1), 970

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See detailIntellectual and social enrichement linked to larger hippocampal volume in healthy aging
Narbutas, Justinas ULiege; Van Egroo, Maxime ULiege; Besson, Gabriel ULiege et al

Poster (2017, November 24)

Introduction. Decreased hippocampal volume in older adults is associated with episodic memory decline and subsequent neurodegenerative diseases. According to the dynamic polygon hypothesis, strategies ... [more ▼]

Introduction. Decreased hippocampal volume in older adults is associated with episodic memory decline and subsequent neurodegenerative diseases. According to the dynamic polygon hypothesis, strategies that increase neurogenesis of the hippocampus are likely to be successsful in delaying the onset of cognitive impairment in ageing. Several modifiable factors can have a positive effect on the size of the hippocampus, one of them being cognitive reserve. However, to date, very few studies reported an impact of cognitive reserve on hippocampal volume in healthy older adults. Therefore, the main objective of our study was to explore whether cognitive reserve is linked to hippocampal volume in healthy aging. We focussed particularly on intellectual and social enrichment during lifespan, because these aspects have been linked to hippocampal volume in clinical populations. Methods. Twenty-six healthy late middle-aged participants (51-69 y.o.) underwent 3T magnetic resonance imaging. Hippocampal volume was calculated with the Automatic Segmentation of Hippocampal Subfields (ASHS) software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of the hippocampus and its subfields. Raw volumetric scores obtained with ASHS were controlled for age and total intracranial brain volume. Only the main hippocampal regions (CA1, CA2, CA3, dentate gyrus) were included in the analysis. Volunteers also completed a questionnaire quantifying their lifespan engagement in intellectual (i.e. reading, hobbies) and social (i.e., volunteering, social games) enrichment. More specifically, participants had to describe the frequency of each activity they have engaged in from 6 years old to the present day. Results. Pearson correlation and hierarchical linear regression analyses revealed that higher frequency of intellectual (r = 0.40; p = 0.023) and social (r = 0.44; p = 0.013) enrichment was significantly linked to larger hippocampal volume, even when controlling for age and sex. Education, another proxy of cognitive reserve, had, however, no significant association with hippocampal volume, possibly due to restricted variance in education and small sample size. Conclusion. These results suggest that in a late middle-aged population, lifespan intellectual and social enrichment is related to larger hippocampal volume. These findings could indicate that lifespan enrichment promotes hippocampal neurogenesis. Future analysis on a larger sample will distinguish the impact of early and later life enrichment on hippocampal volume and will also assess whether this relation can modulate hippocampal-related changes in episodic memory in aging population. [less ▲]

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See detailPhenotyping of PER3 variants reveals widespread effects on circadian preference, sleep regulation, and health
Archer, Simon; Schmidt, Christina ULiege; Vandewalle, Gilles ULiege et al

in Sleep Medicine Reviews (2017), Epub ahead of print

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See detailCircadian and sleep-wake dependent modulations in cognitive brain responses
Schmidt, Christina ULiege

Conference (2017, August 03)

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See detailCognitive brain responses during circadian wake-promotion: evidence for sleep- pressure-dependent hypothalamic activations
Reichert, Carolin Franziska; Maire, Micheline; Gabel, Virginie et al

in Scientific Reports (2017), 7(1),

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See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULiege; Blanpain, Manon ULiege; Van Egroo, Maxime ULiege et al

Poster (2017, May 31)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Method. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region. Discussion. In a late middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects. [less ▲]

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See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULiege; Blanpain, Manon ULiege; Van Egroo, Maxime ULiege et al

Poster (2017, May 19)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Method. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region. Discussion. In a late middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects. [less ▲]

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See detailAssociation entre régulation circadienne du cycle de veille-sommeil et performance de mémoire de travail chez les personnes âgées
Schmidt, Christina ULiege; Reichert, Carolin Franziska; Maire, Micheline et al

Poster (2017, May 19)

Detailed reference viewed: 32 (1 ULiège)
See detailCerebral correlates underlying the impact of circadian and sleep homeostatic processes on cognition
Schmidt, Christina ULiege; Reichert, Carolin; Maire, Micheline et al

Conference (2017, May 11)

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See detailRecognition memory is associated with hippocampal volume in aging population: new evidence from brain imaging study
Narbutas, Justinas ULiege; Blanpain, Manon ULiege; Van Egroo, Maxime ULiege et al

Poster (2017, March 23)

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory ... [more ▼]

Introduction. The hippocampus is crucial for episodic memory, especially for recollection and pattern separation (i.e., the ability to store similar episodes as distinct memory traces). Episodic memory declines with aging and this has been associated with hippocampal dysfunction. The main objective of our study was to explore how performance on a recognition memory task designed to assess pattern separation is associated with hippocampal volume in aging population. Methods. Fourteen healthy late middle-aged participants (52-69 years-old) were evaluated on a Mnemonic Similarity Task (MST). In this task, participants study pictures and then have to discriminate between targets, similar lures, and unrelated foil objects. Recognition memory (RM) is assessed as the difference between hits and false alarms to unrelated foils, while pattern separation Bias metric (BPS) is the difference between the rate of ‘‘Similar’’ responses given to the lure items minus ‘‘Similar’’ responses given to the foils. Hippocampal volume was calculated using ASHS software, which uses T1-weighted and T2-weighted MRI to obtain optimal segmentation of hippocampal subfields. Results. Correlation analysis of preliminary data revealed that RM was significantly positively associated with the volume of the left subiculum and left perirhinal area 35, while there were no significant correlations in the right hemisphere. BPS was positively correlated with the volume of right CA2 region, but negatively associated with the volume of right CA3 region, what is more contradictory according to the current literature. No significant link was found between BPS and the volume of hippocampal subfields in the left hemisphere. Conclusion. In a middle-aged population, better visual recognition memory is associated with larger volume of the left subiculum and perirhinal area 35, two regions supporting representation of objects [less ▲]

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See detailChronobiological research for cognitive science: A multifaceted view
Schmidt, Christina ULiege; Bao, Yan

in Psych J (2017), 6

Detailed reference viewed: 17 (2 ULiège)
See detailRythmes biologiques, écrans LED et adolescence Influence sur le cycle veille - sommeil et les performances cognitives
Schmidt, Christina ULiege

Conference given outside the academic context (2016)

Detailed reference viewed: 35 (2 ULiège)