References of "Purnelle, Audrey"
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See detailDopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
Borgs, Laurence; Peyre, Elise ULiege; Alix, Philippe et al

in Scientific Reports (2016), 6

Some mutations of the LRRK2 gene underlie autosomal dominant form of Parkinson's disease (PD). The G2019S is a common mutation that accounts for about 2% of PD cases. To understand the pathophysiology of ... [more ▼]

Some mutations of the LRRK2 gene underlie autosomal dominant form of Parkinson's disease (PD). The G2019S is a common mutation that accounts for about 2% of PD cases. To understand the pathophysiology of this mutation and its possible developmental implications, we developed an in vitro assay to model PD with human induced pluripotent stem cells (hiPSCs) reprogrammed from skin fibroblasts of PD patients suffering from the LRKK2 G2019S mutation. We differentiated the hiPSCs into neural stem cells (NSCs) and further into dopaminergic neurons. Here we show that NSCs bearing the mutation tend to differentiate less efficiently into dopaminergic neurons and that the latter exhibit significant branching defects as compared to their controls. [less ▲]

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See detailp27(Kip1) as a master regulator of cortical neuron migration.
Godin, Juliette ULiege; Thomas, Noémie; Laguesse, Sophie ULiege et al

Conference (2013, June)

Detailed reference viewed: 37 (12 ULiège)
See detailp27(Kip1) as a master regulator of cortical neuron migration.
Godin, Juliette ULiege; Thomas, Noémie; Laguesse, Sophie ULiege et al

Poster (2013)

Detailed reference viewed: 16 (1 ULiège)
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See detailp27(Kip1) Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration.
Godin, Juliette ULiege; Thomas, Noemie; Laguesse, Sophie ULiege et al

in Developmental Cell (2012), 23(4), 729-44

The migration of cortical interneurons is characterized by extensive morphological changes that result from successive cycles of nucleokinesis and neurite branching. Their molecular bases remain elusive ... [more ▼]

The migration of cortical interneurons is characterized by extensive morphological changes that result from successive cycles of nucleokinesis and neurite branching. Their molecular bases remain elusive, and the present work describes how p27(Kip1) controls cell-cycle-unrelated signaling pathways to regulate these morphological remodelings. Live imaging reveals that interneurons lacking p27(Kip1) show delayed tangential migration resulting from defects in both nucleokinesis and dynamic branching of the leading process. At the molecular level, p27(Kip1) is a microtubule-associated protein that promotes polymerization of microtubules in extending neurites, thereby contributing to tangential migration. Furthermore, we show that p27(Kip1) controls actomyosin contractions that drive both forward translocation of the nucleus and growth cone splitting. Thus, p27(Kip1) cell-autonomously controls nucleokinesis and neurite branching by regulating both actin and microtubule cytoskeletons. [less ▲]

Detailed reference viewed: 58 (20 ULiège)
See detailp27(Kip1) as a master regulator of cortical neuron migration.
Godin, Juliette ULiege; Thomas, Noémie; Laguesse, Sophie ULiege et al

Poster (2012)

Detailed reference viewed: 15 (1 ULiège)
See detailp27(Kip1) as a master regulator of cortical neuron migration.
Godin, Juliette ULiege; Thomas, Noémie; Laguesse, Sophie ULiege et al

Poster (2012)

Detailed reference viewed: 11 (1 ULiège)
See detailCortical interneurons tangential migration : p27(Kip1) as a novel master regulator.
Godin, Juliette ULiege; Thomas, Noémie; Laguesse, Sophie ULiege et al

Poster (2012)

Detailed reference viewed: 22 (4 ULiège)
See detailp27(Kip1) as a master regulator of cortical neuron migration
Godin, Juliette ULiege; Thomas, Noémie; Laguesse, Sophie ULiege et al

Scientific conference (2011, June)

Detailed reference viewed: 29 (4 ULiège)